Plasmid_ID Protein_ID Orf Prediction Source Start End Strand VFSeq_ID Identity E-value Gene_Name Product VFID VF_Name VF_FullName VFCID Vfcategory Characteristics Structure Function Mechanism Sequence Kraken2_NZ_JAQLSH010000476.1 IMICODJL_00102 Prodigal:2.6 19961 21346 + VFG034652(gb|WP_000074204) 72.3 1.79e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALNNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYNGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_JAQLSH010000478.1 IMICODJL_00326 Prodigal:2.6 63091 64476 - VFG034652(gb|WP_000074204) 72.3 1.79e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALNNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYNGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_JAMRYS010000102.1 IMICODJL_00470 Prodigal:2.6 7898 8245 + VFG043478(gb|WP_005752194) 100.0 1.6900000000000002e-73 (PM_RS08640) ComEA family DNA-binding protein VF1230 ComE1 VFC0001 Adherence MKLKSLLFSVFVFVSLSNSSNVCAESANMTKAKTEHAVVQNIQSKPQDTLNEKVNINTASATDLQQKLLGIGAKKAEAIIQHREKHGPFTDIEQLRDIQGIGQAILEKNKTRLQL Kraken2_NZ_JAMRYS010000102.1 IMICODJL_00471 Prodigal:2.6 8366 8974 + VFG013265(gb|WP_005694045) 83.2 1.55e-107 (orfM) deoxyribonucleotide triphosphate pyrophosphatase VF0044 LOS VFC0258 Immune modulation Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. Comprising Lipid A, an inner core of one molecule 3-deoxy-D-manno-oct-2-ulopyranosonic acid (Kdo) and three molecules of heptose, and an outer core composed of a heteropolymer of the neutral sugars glucose and galactose. Substitution of the out core with phosphorylcholine or sialic acid results in the heterogeneity of LPS; Lack O-antigen Major immunogen; LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals; LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments Lic1(lic1A-lic1D) responsible for the addition of phosphorylcholine to LPS. lic1A mediates phase variation (tetranucleotide repeat region); phase-variable gene lic3A encodes an alpha-2,3-sialyltransferase that is responsible for the addition of Neu5Ac to terminal lactose in the LPS, LPS sialylation has been shown to be important for resistance to the killing effectors of normal human serum MKQKIVLATGNLGKVKEMSDVLADFGFEVIAQTELNIESPEETGLTFVENALLKARYASKMSGLPAIADDSGLVVPALGGAPGLYSARYAGVDGPDADAKNRAKLLHALHHIAPTHRQAKFVSCIVMLQHEHDPSPIIAEGECYGEIGFAEKGENGFGYDSLFFSPEVNCTFAELTTSEKKKISHRAKALSVLQTKLATKGA Kraken2_NZ_JAMRYS010000102.1 IMICODJL_00474 Prodigal:2.6 9990 11144 + VFG013626(gb|WP_011272071) 78.0 1.53e-222 (hemN) radical SAM family heme chaperone HemW VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MNINRLPPLSLYIHIPWCVQKCPYCDFNSHAQKGHIPEQDYIAHLLQDLHQDRQRFQDSIQDRSLHSIFIGGGTPSLFSAEGIHTLLSGVAQCLPFQPDIEITLEANPGTAEAERFKGYVQAGVTRISMGIQSFNDDKLVRLGRIHNAQEAKSAVGFAKLSGLKSFNLDLMHGLPNQTLEEALSDLQQAIALEPPHLSWYQLTIEPNTMFAYRPPVLPDDDALWDIFEQGHQLLTEAGYVQYETSAYAKPAFQCRHNLNYWRFGDYLAIGCGAHGKITQPNGEIKRYSKTKHPKGYMRGDYLYEEKTVATEDLAFEFFMNRFRLLEAVPKTDFTRLTGLCEESIQPQIQWALAKKYLVETEVAWQVTEQGKLFLNELLAEFLPK Kraken2_NZ_JAMRYS010000102.1 IMICODJL_00495 Prodigal:2.6 31574 32599 + VFG013197(gb|WP_011608705) 84.8 8.75e-212 (hemB) porphobilinogen synthase VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MTQQIFASFPQRRLRRMRKQAFSRRLMAENKLSVEDLIYPVFIIEGEKQREPVPSMPGVERLTIDELLIEAELLVKYGVPVIALFPVIAQEKKSLMAEEAYHPDGLVQRAVKALKDKFPTELGILTDIALDPYTTHGQDGIIDQQGYVLNDVTSDILVKQALSHAKVGADIVAPSDMMDGRIGKIRHALEEKGFINTLIMAYSAKYASHYYGPFRDAVGSATNLKGGDKKTYQLDPANSDEGLQEVALDLQEGADMVMVKPGMPYLDLVYRVKTHFGVPTFAYQVSGEYAMHQAAIQNGWLKEKECIMESLLCFKRAGADGILTYYAKQVAEWLYWEKQHQ Kraken2_NZ_JAMRYS010000102.1 IMICODJL_00507 Prodigal:2.6 42032 44599 + VFG049189(gb|WP_014226431) 77.5 0.0 (clpV) ATP-dependent chaperone ClpB VF0783 T6SS-II VFC0086 Effector delivery system MNIEKFTTKFQQALQEAQSLAIGKDNQFIEPVHLLTALLNQQGGSTAPILTASGANLPLLRNELNAELSKLPQVSGSGGDVQVSRSLVNLLNLCDKLAQQRQDKFISSELFLLAVLEDKTLGDVLKKCGVKKENLQQAIEKVRGGQNVNDPNAEESRQALEKYTIDLTARAESGKLDPVIGRDEEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKNKRVLSLDMGALIAGAKYRGEFEERLKAVLNELSKEEGRVILFIDEIHTMVGAGKTDGAMDAGNLLKPSLARGELHCVGATTLDEYRQYIEKDAALERRFQKVFVGEPTVEDTIAILRGLKERYEIHHHVQITDPAIVAAATLSHRYVSDRQLPDKAIDLIDEAASSIRMEIDSKPQPLDRLERRIIQLKLEQQALQKEDDDASRKRLAMLEKELGEKEREYAELEDVWKAEKAALSGTQHIKAELDSAKTQMEQARRASDFAKMSELQYGVIPALEKQLAQAESAEGKEMTLLRYRVTDEEIAEVLSRATGIPVAKMMEGEKEKLLRMEEELHKRVIGQHEAIEAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKTLANFLFDDENAMVRIDMSEFMEKHSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHHDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNLGSHLIQENSTLDYPSMKELVMSVVGQHFRPEFINRIDETVVFHPLGKENIREIATIQLARLIKRMESHGYQLHFTDACLDFIGEVGYDPVYGARPLKRAIQQEIENPLAQQILSGKLLPNQLVTIDYVDGKVIANQ Kraken2_NZ_JAMRYS010000104.1 IMICODJL_00582 Prodigal:2.6 14822 16156 - VFG013118(gb|WP_005693728) 63.0 2.46e-176 (comE/pilQ) type IV pilus secretin PilQ family protein VF0753 Type IV pili VFC0001 Adherence MWRAFRKISFVYFLCGVAYVGSSQAQDAEHFYLRLKQAPLVEMLQYLALQQHQDLLIDDHLEGTLSLQMKKTTFEKCLQSIARMKQLELHQEGKSYYLTSPSGVAANDTHHPTSLMTSSIKLHFAKAAEVVKSLTSGQGSLLSVGGSLSFDERTNLLLIQDEPQSIQRIKALVAEMDKPIEQIAIEARIVTMTDESLQELGVRWGLFQATEQAHTIAGSLAANGFSNIENQLNVNFSTNSTPVGSIALQLAKINGRLLDLELTALEREKHIEIIASPRLLTTNKKSASIKQGTEIPYVMKRGKDKSESVEFREAVLGLDVTPHISKDNSILLDLLITQNTLGAPVVYDKGEIVSIDKQEINTQVVAQDGETIVLGGVFHDTMTKGVNKVPLLGDLPLLKHVFSQKTERHQKRELVIFVTPHIIKSSQGSPEQKTTRVKKSAKSR Kraken2_NZ_JAMRYS010000105.1 IMICODJL_00600 Prodigal:2.6 9101 9742 - VFG042734(gb|NP_249343) 62.9 5.06e-90 (vfr) cAMP-regulatory protein VF0082 Type IV pili VFC0001 Adherence PilA, B, C, D, E, F, M, N, O, P, Q, T, U, V, W, X, Y1, Y2, Z, and fimT, U, V are involved in the biogenesis and mechanical function of pili, pilG, H, I, K, chpA, B, C, D, E, pilS, R, fimS, rpoN, algR, algU, and vfr are involved in transcriptional regulation and chemosensory pathways that control the expression or activity of the twitching motility of the pili Attaches to host cells, but not to mucin, causing a twitching motility that allows the bacteria to move along the cell surface; biofilm formation The C-terminal receptor-binding domain of pilin binds to asialoGM1 gangliosides on host cells. Generally, GM1 gangliosides contain a sialic acid moiety. P.aeruginosa produces a neuraminidase which removes sialic acid residues from the GM1 to form the asialoGM1, which is a better receptor for the pili; The asialoGM1 is present in increased abundance on the surface of cystic fibrosis respiratory epithelial cells MQEQMQTTPSIDPTLEWFLSHCHIHKYPSKSTLIHAGEKAETLYYLIKGSVTVLVKDEDGKEMILTYLSQGDFFGEAGLFEEGQLRSAWIKAKSPCEIAEISYKKFRQLIQVNPDILMHLSAQLARRLQNTSRQVSNLAFLDVTGRIAQTLLNLAKMPEAMTHPDGMQIKITRQEIGQMVGCSRETVGRILKMLEDQYLISAHGKTIVVYGTR Kraken2_NZ_JAMRYS010000111.1 IMICODJL_00699 Prodigal:2.6 1255 2328 - VFG013510(gb|WP_011961857) 82.1 3.06e-199 (wecA) undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase VF0044 LOS VFC0258 Immune modulation Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. Comprising Lipid A, an inner core of one molecule 3-deoxy-D-manno-oct-2-ulopyranosonic acid (Kdo) and three molecules of heptose, and an outer core composed of a heteropolymer of the neutral sugars glucose and galactose. Substitution of the out core with phosphorylcholine or sialic acid results in the heterogeneity of LPS; Lack O-antigen Major immunogen; LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals; LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments Lic1(lic1A-lic1D) responsible for the addition of phosphorylcholine to LPS. lic1A mediates phase variation (tetranucleotide repeat region); phase-variable gene lic3A encodes an alpha-2,3-sialyltransferase that is responsible for the addition of Neu5Ac to terminal lactose in the LPS, LPS sialylation has been shown to be important for resistance to the killing effectors of normal human serum MLLSLIVTFLGAFLTLLFMRPIAQKIGLVDKPNFRKRHQGAIPLIGGVSLFVGNLCFYLLEWEQMRLPTLYLFSIFVLLVIGMIDDRFDISPFLRAGIQAILAILMIDLGNLYLDHLGQILGPFQLTLGSIGLIITVLATIAAINAFNMIDGIDGLLGGLSSVAFVSIGILLIKDNQLDLAYWSFALIIAILPYFMMNLGIPFGQKFKVFMGDAGSTLIGFTIIWILLLSTQGKGHPMNPVTALWIIAIPLIDMIAIMYRRLRKGKSPFRPDRLHVHHLMMRAGLTSRQAFLLITFAAAICATIGILGEIFYINEWLMFAGFILLFFMYSYSITRAWRITRWIRRMRRRAKRIHNKG Kraken2_NZ_JAMRYS010000111.1 IMICODJL_00700 Prodigal:2.6 2461 3744 + VFG013618(gb|WP_011609384) 80.8 5.12e-258 (hemL) glutamate-1-semialdehyde 2,1-aminomutase VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MTTSLSLFQRAQHRIPGGVNSPVRAFKGVGGTPIFIEKAQGAYLYDTEGNQYIDYVGSWGPMILGHNHPTILDAVISTAQNGLSFGAPTALEIELAELVCSLVPSIDMVRMVSSGTEATMSAIRLARGYTKRDKIIKFEGCYHGHADSLLVKAGSGALTLGQPSSPGVPADFAKHTLTCTYNDLDSVKHAFEQYPNEIACLIVEPVAGNMNCIPPQEGFLQGLRALCDQYGAVFIIDEVMTGFRVALGGAQTYYGVTPDLTCLGKVIGGGMPVGAFGGKKAIMQHIAPLGPVYQAGTLSGNPIAMAAGLACLTELKKAGNAQRLAQQTEKLALGLKALADKHHVPFVVNYVGGMFGIFFTEQKTVSSYQAVMACDTEKFNRFFHAMLAQGIYLAPSAFEAGFMSLAHSDQDIERTLQAADQVFSQLA Kraken2_NZ_JAMWMJ010000028.1 IMICODJL_00740 Prodigal:2.6 3905 7468 - VFG050211(gb|WP_010968279) 60.1 0.0 (cna) collagen adhesin VF0730 Cna VFC0001 Adherence MSKRKRFKLITTITLIFTFLLTNIKVFAVEINSTDAESYLNYNSPTWGKVLPIGNHRYYAPDLRTCYCLNTGALNPTGQDYTEEIPVDGGIETIIYWGYPAKDGSEWGISADEYRYCTQLAIWAYQKEAGLSRGIDRTRLQNGTVSLSRLKPVIDFLVEKGLNKELPTFFEVTPSNIVAHQEGDYFVSEPIKIKSDYEFKDAKVTIKSSSNPGLKDIVKIKDMDGDERNTYNSNESFRVYIPIDAETGDIKVDVKATVELPASLAYATPVAGKQDMALVDLRYQNMNKDNVTVSWTGLNGAIELVKKGDDGSLLTGAKFVLKNKEGNQIAEATSENGRVVFNDIKPGEYIIEEVEAPLGYLITNPVNITVKPNKVTTAEMVDTQIKGRVEITKIDEETGEPISGAEFEMVKADNNEVVEKMTTGENGKVLSGLHPFGNYIVRETKAPSKYVLNGKEYPVTINEHMKTIEITHANRKIKGRVSIHKIDEEMPELSLKGAVLGIYDDAGNEVDRLTTDEKGAATSKYLDYGHYIGKELQAPEGYKLSDKTIDINITEDDKVYSYDFTNKVMKGRIQIVKVDSENEEKPVANAGFKVVAVNVNGIEPGTTVDKVKTDENGFAFTKDLRYGVYKFIEDETPEGYWASDKEYTININEDNKVYVKYVKNAPIQAKLRVVKVDSKDNKPLEGVKFQVRNTDTNKLVEFTNFVGIIPNKTTTLTTDKNGEIITPQHLAYGNYQLEEAKPKDGYISIKPIPFKIDENAALEDIKDLGTVYTIKVSNDRITGDMELLKIDSETKKPLADIEFKVTALDGLMKGQTWDLKSNDKGIVSLKGLEYGHYKIEEVKTLWNYVINKEPIFFDVKENGQVIKLEMENKKIRANAELIKVDSETKRPLEGAEFELWNGENLVGNYTTNKDGKIVVENLEAGNYYFNEIKAPDHYEINQDQDLSFVIDKDGETKTVTAENKVKTGEVDFTKTDVTNGQNIEGAKIEIVGIEEQNKHVKFEFTSSLAGNKFTLPEGKYEFRETQQPEGYELSTEVGTFEIKGGEIIKANLKNERTTGKLIFTKTDVATGEVLEGAKIKIECLSGLDKGKVIEFISSKNGNEFELAAGEYKISETQAPEGYELTTETGTFKIGEHGEVVKCNLTNKKFEIVKTGSSFDVNALIPFGIILVTGGLGALILSKKRKLS Kraken2_NZ_JAMWMJ010000029.1 IMICODJL_00836 Prodigal:2.6 51112 52086 - VFG019385(gb|WP_003728858) 75.6 1.64e-185 (bsh) bile salt hydrolase VF0350 BSH VFC0282 Stress survival The bsh gene is positively regulated by the central listerial virulence regulator PrfA in vivo Involved in resisting the acute toxicity of bile and bile salts, important for intestinal persistence of L. monocytogenes Bile salts are the end products of the cholesterol metabolism in the liver and are stored in the gall bladder and released into the duodenum, helping fat digestion. In addition, bile salts are known to have antimicrobial activity since they are amphipathic molecules which can attack and degrade lipid membranes. BSH can transform and inactive the bile salts by catalyzing the hydrolysis of the amide bond, liberating the glycine/taurine moiety from the side chain of the steroid core. MCTAITYTTKNNYFGRNFDYEISYNEKVVITPRNFPFKFRKVNDINQHYAFIGVATVVDDYPLYYDATNEKGLSIAGLNFEGNAYYGEEVKGKLNIAPFEFIPWILGQCSTIKEVKKLLEQINFVNINFSEKLPLSPLHWLVADKNESIVIENLKTGLKIYDNPVGVLTNNPTFDYQLFNLNNYQNLSTQTPNNLFSKNINLNSYSRGMGGLGLPGDLSSMSRFVKATFTKLNSVSGDSESESISQFFHILGSVEQQKGLCDVGGKNYEYTIYSSCCNIDRGIYYYKTYENSQITAVDMNKEDLESSTLFTYNLINNQIINYLN Kraken2_NZ_JAMRYT010000034.1 IMICODJL_00946 Prodigal:2.6 24309 26876 - VFG049189(gb|WP_014226431) 77.6 0.0 (clpV) ATP-dependent chaperone ClpB VF0783 T6SS-II VFC0086 Effector delivery system MNIEKFTTKFQQALQEAQSLAIGKDNQFIEPVHLLTALLNQQGGSTAPILTASGANLPLLRNELNAELSKLPQVSGSGGDVQVSRSLVNLLNLCDKLAQQRQDKFISSELFLLAALEDKTLGDVLKKCGVKKENLQQAIEKVRGGQNVNDPNAEESRQALEKYTIDLTARAESGKLDPVIGRDEEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKNKRVLSLDMGALIAGAKYRGEFEERLKAVLNELSKEEGRVILFIDEIHTMVGAGKTDGAMDAGNLLKPSLARGELHCVGATTLDEYRQYIEKDAALERRFQKVFVGEPTVEDTIAILRGLKERYEIHHHVQITDPAIVAAATLSHRYVSDRQLPDKAIDLIDEAASSIRMEIDSKPQPLDRLERRIIQLKLEQQALQKEDDDASRKRLAMLEKELGEKEREYAELEDVWKAEKAALSGTQHIKAELDSAKTQMEQARRASDFAKMSELQYGVIPALEKQLAQAESAEGKEMTLLRYRVTDEEIAEVLSRATGIPVAKMMEGEKEKLLRMEEELHKRVIGQHEAIEAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKTLANFLFDDENAMVRIDMSEFMEKHSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHHDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNLGSHLIQENSTLDYPSMKELVMSVVGQHFRPEFINRIDETVVFHPLGKENIREIATIQLARLIKRMESHGYQLHFTDACLDFIGEVGYDPVYGARPLKRAIQQEIENPLAQQILSGKLLPNQLVTIDYVDGKVIANQ Kraken2_NZ_JAMRYT010000034.1 IMICODJL_00958 Prodigal:2.6 36426 37451 - VFG013197(gb|WP_011608705) 85.0 7.51e-213 (hemB) porphobilinogen synthase VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MTQQIFASFPQRRLRRMRKQAFSRRLMAENKLSVEDLIYPVFIIEGEKQREPVPSMPGVERLTIDELLIEAELLVKYGVPVIALFPVIAQEKKSLMAEEAYHPDGLVQRAVKALKDKFPTELGILTDIALDPYTTHGQDGIIDQHGYVLNDVTSDILVKQALSHAKAGADIVAPSDMMDGRIGKIRHALEEKGFINTLIMAYSAKYASHYYGPFRDAVGSATNLKGGDKKTYQLDPANSDEGLQEVALDLQEGADMVMVKPGMPYLDLVYRVKTHFGVPTFAYQVSGEYAMHQAAIQNGWLKEKECIMESLLCFKRAGADGILTYYAKQVAEWLYWEKQHQ Kraken2_NZ_JAMRYT010000034.1 IMICODJL_00982 Prodigal:2.6 60490 61644 - VFG013626(gb|WP_011272071) 77.8 6.240000000000002e-222 (hemN) radical SAM family heme chaperone HemW VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MNINRLPPLSLYIHIPWCVQKCPYCDFNSHAQKGHIPEQDYIAHLLQDLHQDRQRFQDSIQDRSLHSIFIGGGTPSLFSAEGIHTLLSGVAQCLPFQPDIEITLEANPGTAEAERFKGYVQAGVTRISMGIQSFNDDKLVRLGRIHNTQEAKSAVGFAKLSGLKSFNLDLMHGLPNQTLEEALSDLQQAIALEPPHLSWYQLTIEPNTMFAYRPPVLPDDDALWDIFEQGHQLLTEAGYVQYETSAYAKPAFQCRHNLNYWRFGDYLAIGCGAHGKITQPNGEIKRYSKTKHPKGYMRGDYLYEEKTVATEDLAFEFFMNRFRLLEAVPKTDFTRLTGLCEESIQPQIQWALAKKYLVETEVAWQVTEQGKLFLNELLAEFLPK Kraken2_NZ_JAMRYT010000034.1 IMICODJL_00985 Prodigal:2.6 62660 63268 - VFG013265(gb|WP_005694045) 83.2 2.2e-107 (orfM) deoxyribonucleotide triphosphate pyrophosphatase VF0044 LOS VFC0258 Immune modulation Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. Comprising Lipid A, an inner core of one molecule 3-deoxy-D-manno-oct-2-ulopyranosonic acid (Kdo) and three molecules of heptose, and an outer core composed of a heteropolymer of the neutral sugars glucose and galactose. Substitution of the out core with phosphorylcholine or sialic acid results in the heterogeneity of LPS; Lack O-antigen Major immunogen; LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals; LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments Lic1(lic1A-lic1D) responsible for the addition of phosphorylcholine to LPS. lic1A mediates phase variation (tetranucleotide repeat region); phase-variable gene lic3A encodes an alpha-2,3-sialyltransferase that is responsible for the addition of Neu5Ac to terminal lactose in the LPS, LPS sialylation has been shown to be important for resistance to the killing effectors of normal human serum MKQKIVLATGNLGKVKEMSDVLADFGFEVIAQTELNIESPEETGLTFVENALLKARYASKMSGLPAIADDSGLVVPALGGAPGLYSARYAGVDGPDADAKNRAKLLHALHHIAPTHRQAKFVSCIVMLQHEHDPSPIIAEGECYGEIGFAEKGENGFGYDSLFFSPEVNCTFAELATSEKKKISHRAKALSVLQTKLATKGA Kraken2_NZ_JAMRYT010000034.1 IMICODJL_00986 Prodigal:2.6 63389 63736 - VFG043478(gb|WP_005752194) 100.0 1.6900000000000002e-73 (PM_RS08640) ComEA family DNA-binding protein VF1230 ComE1 VFC0001 Adherence MKLKSLLFSVFVFVSLSNSSNVCAESANMTKAKTEHAVVQNIQSKPQDTLNEKVNINTASATDLQQKLLGIGAKKAEAIIQHREKHGPFTDIEQLRDIQGIGQAILEKNKTRLQL Kraken2_NZ_JAMRYU010000187.1 IMICODJL_01094 Prodigal:2.6 1082 1879 + VFG012122(gb|WP_010968250) 99.6 3.12e-190 (cpb2) beta2-toxin VF0417 Beta2-toxin VFC0235 Exotoxin No significant homology with the sequence of the beta-toxin (only 15% identity) or with any other known protein sequence, but displayed similar biological activity as the beta-toxin.; The beta2-toxin is encoded either by the so-called consensus gene/allele or by the atypical gene/allele. Unknown. MKKIISKFTVIFMFSCFLIVGAISPMKASAKEIDAYRKVMENYLNAFKNYDINTIVNVSEDERVNSDEKYKEMLEEFKYDPNQQLKSFEILNSQKIDNKEIFNVKTEFMNGAIYDMKFTVSSKDGELIVSDMERTKIENEGKYILTPSFRTQVCTWDDELSQSIGGVDPKTYSTRFTYYADNILLNFRQYATSGSRDLKVEYSVVDHWLWGDDVKASQMVYGQNPDSARQIRLYIEKGQSFYKYRIRIQNFTPASIRVFGEGYCA Kraken2_NZ_JAMRYU010000187.1 IMICODJL_01136 Prodigal:2.6 38906 43012 - VFG050211(gb|WP_010968279) 98.8 0.0 (cna) collagen adhesin VF0730 Cna VFC0001 Adherence MSKVKRFKLITTITLIFTFLFTNIKVFAVEITSTDAESYLNYDSPTWGKVLPIGNHRYYVPGDLTTCYCLNTGALNPTGQDYTKEMQVDAGIETILYWGYPAKDGSDWGISADEYRYCTQLAIWAYQKEAGLSRGLVRERLQSGTVPLSKLKLVIDFLVDKAHNKEMPTFFEVSPNDIIAHQEGDYFVSEPIKIKSNYTLSGVKVTIKSASNSELTKDIVIKDMDGNVKDSGYKANESFRVYIPSNAETGDLKVSVKAKVDIPAMLGYMTPEQGIQDMAVSSLDTHSMDKDNIKVSWTGLNGAVQVIKKGDDGKLLTGAKFVLKNANDENVAEATSQDGKAVFNDIKPAEYTIHEVEAPQGYLVTNPVNVTVKPNKVSIAEMTDTQIKGKIQVLKVDEETNTPLQGAEFEITQDGKHIETITTGENGIATSSLLPFGNYLVKEIKAPSKYVLNGEEHPVTISENGKTIEITHTNKIIKGKVAVKKTDSEISDLNLEGAEFTIYDNNKNIVATITTNKDGYAESEPLNYGTYTMQETKAPKGYLLSNKVWDININENDKTYTFDVSNDVIKGKLQIVKVDSENEEKPVEGAGFDVIAVNVNGIKEGTVVDHVVTDKNGFAYTKDLRYGDYKFHETDTPKGYWKSDKEYSFNIAENGKTYVKYVKNSPIQAKVRVIKVDSKDGKPLKGVKFQIRNADTKKLVEFTNFIGIIPMKTTTLETNKNGELVTPQNLAYGNYLLEEVEPLEGYIKVNPIPFKIDENSVLEEIKDLGTIYTQKVSNDRITANMELLKLDKETNKPLENIEFKVTALDGFMKGKTWNLKSDDKGLVSLKGLEYGDYRVDEVKTLWNYVLNKEPIFFSVKENGKTIKLQMTNKKIRGSVELFKFDKDTNRPLEGVKFDLLNGDKKVGTYTTDNTGKITVNNLEASNYTWVEVEAIDHYNKVDKKYDFNIYKDGQLEKIDVANTVKTEELDFSKTDVTTGDSIDGAKVKITGLEPQNKHINIEFTSSKEGNKFTLPEGKYTFEEILAPEGYRINKEVGTFEIKDGEITKANLKDERKQGDLIFTKTDVTDGKVIEGAKIKITCIEGLSKGKVIDFTSSKNGNKFTLDEGKYTFEETSAPNGYRINKEVGTFEIKDGEITKANLKDERKQGNLEFTKTDVTDGRIIEGAKIKIICVEGLSKGKVIEFTSFKDGNKFTLDEGKYTFEEISAPNGYEINKEVGTFEIKDGEITKANLKDERTTGVLEFTKTDIATGEVLEGAHIKIECLEGLDQGKVIEFTSSKEGNKFTLAKGKYRISETKAPEGYELTTETGEFEITNQGDIITCNLTNKKIEIVKTGNSFDINSLIPLGILLVAGGIGGLFFTKKRKLS Kraken2_NZ_JAMRYU010000187.1 IMICODJL_01145 Prodigal:2.6 51751 52725 + VFG019385(gb|WP_003728858) 75.6 1.64e-185 (bsh) bile salt hydrolase VF0350 BSH VFC0282 Stress survival The bsh gene is positively regulated by the central listerial virulence regulator PrfA in vivo Involved in resisting the acute toxicity of bile and bile salts, important for intestinal persistence of L. monocytogenes Bile salts are the end products of the cholesterol metabolism in the liver and are stored in the gall bladder and released into the duodenum, helping fat digestion. In addition, bile salts are known to have antimicrobial activity since they are amphipathic molecules which can attack and degrade lipid membranes. BSH can transform and inactive the bile salts by catalyzing the hydrolysis of the amide bond, liberating the glycine/taurine moiety from the side chain of the steroid core. MCTAITYTTKNNYFGRNFDYEISYNEKVVITPRNFPFKFRKVNDINQHYAFIGVATVVDDYPLYYDATNEKGLSIAGLNFEGNAYYGEEVKGKLNIAPFEFIPWILGQCSTIKEVKKLLEQINFVNINFSEKLPLSPLHWLVADKNESIVIENLKTGLKIYDNPVGVLTNNPTFDYQLFNLNNYQNLSTQTPNNLFSKNINLNSYSRGMGGLGLPGDLSSMSRFVKATFTKLNSVSGDSESESISQFFHILGSVEQQKGLCDVGGKNYEYTIYSSCCNIDRGIYYYKTYENSQITAVDMNKEDLESSTLFTYNLINNQIINYLN Kraken2_NZ_JAMWMK010000146.1 IMICODJL_01281 Prodigal:2.6 32408 32950 - VFG042989(gb|ACI49672) 83.6 1.75e-54 (ACI49672) putative housekeeping sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MEMRKWLFGFLGVALIVFCSVFGYVSYQKHEGEVFKQNIEKKMPVDQINAHAKSYKEDATNVNNDMSLGQMLSIQQEAIEMGVNKQVFAQIFVDPSITDKKERFKAATNFILKNENKLERVENLHFETEKYKDHPIDYQPLTEKGRSYLKEERKLPDWLIDYAEKEGLIAELFIRRIVGM Kraken2_NZ_JAMWMK010000149.1 IMICODJL_01329 Prodigal:2.6 20430 21101 + VFG042989(gb|ACI49672) 96.9 8.250000000000003e-156 (ACI49672) putative housekeeping sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKKWLFVFLGVALIVFCSVFGYVSYQKHEGEVFKQNIEKKMPVDQINAHAKSYKEDAMNVNNDMSLGQMLSIQKEAIEMGVNEQVFAQIQIPVLGLALPIFKGANQYTLSLGAATYFYEDAEMGKGNYVLAGHNMEMPGVLFSDIQKLSLGEVMNLVSNDGVYRYKVTRKFIVPEYFKLIDGIPEENSFLSLPKKGENPLLTLFTCVYTSQGKERYVVQGELQ Kraken2_NZ_JAMWMK010000149.1 IMICODJL_01330 Prodigal:2.6 21154 23130 + VFG042988(gb|ACI49671) 97.3 0.0 (pilA) PilA VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MAINRYVKKAGMLVGMLVIIAGCFQGYRAYAEDVTQKTPPEKVNITVHKLMYDQSTQLNVDIDGIKNDGYTHDQYPTGVTKYNKADYGDVEFTLGNITDQVLPREDSDLTNAKVDEIVKDVEDKGSNSEYVKNATNKITSAVDENGEITFADQPAYVNSKGNVYVVYESKSAAGLVTQKAKPMVVIAPMTDNTGSGFLKDIHLYPKNIVSKLSFELTKFGDDGTAQSKQTPLKGAKFELYKGEPGKGTKLGDLVANDQGKLTATDLTLGKYYFVEVPSEVVVGSDKEPTTDQYLLGADARNDAHNKLTFEITNDGVTSDLKASYVNYKAPVIDKTVTNGTGQEHSFQIGDAVNYQGTIHIPTDIAGGADGITVNGVKSETSPYSVFKWGDTAGKGLFYVAAKANIKVTNRDGSVVLKENTDYKIQNSENGFVIDFIVNNGQVSDTVVSLHGQDLQMTYNMYVNDSAAVANPLTNSVDFVYNNNPFNQEEHHEKTKADVVTYGAKFLKVDSGLFGTGIKATPLEGAEFAAKNAEGNYYGGLVDTDKDGVKEVVWVDDVANAAILKSDKEGHFEITGLAEGEYSLEETKAPENYQKLTKEISFNVDKDSYKEENRITIKNNQKASVPMTGSNGFQTYVLISCLLLGAGALSAVVYFKKKA Kraken2_NZ_JAMWMK010000149.1 IMICODJL_01331 Prodigal:2.6 23145 23897 + VFG042987(gb|ACI49670) 99.2 1.27e-177 (ACI49670) putative pilus-dedicated sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MIIRKPKKKRIMGKWIIAFWLLSAVGVLLLMPAEASVAKYQQNQQIAAIDRTGTAAETDSSLDVAKIELGDPVGILTIPSISLKLPIYDGTSDNILENGVGITEGTGDITGGNGKNPLIAGHSGLYKDNLFDDLPSVKKGEKFYIKVDGEQHAYQIDRIEEVQKDELQRNFVTYLEPNPNEDRVTLMTCTPKGINTHRFLVYGKRVTFTKSELKDEENKKQKLSWKWLLGSTVFLSVMIIGSLFVYKKKK Kraken2_NZ_JAMWMK010000149.1 IMICODJL_01332 Prodigal:2.6 23913 24674 + VFG042986(gb|ACI49673) 94.1 5.69e-150 (ACI49673) cell wall-associated LPXTG-like protein VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKNRKWLFVCAAALLSFTAYTQLTFADSQESADNTEQTMQTSDSSTIQSSDETVDSSTVDSSEEPKIAEDNQIVKQTIHVQKIISSEQLDNQGQKLEKQEGVNGAKFSVYDVSDILQKMDVKDLTTDQIESQLKDRVKKLSSDQLKLVSNGETKTIDQQTGVFEFSVEVQANQKQAYYIVNESSPENISNSEDILLLTPVSDKDGEFLKDVWIYPKSEASQPKEEVKKIVSTGVKKNFFEHCWDFVTHLFSRN Kraken2_NZ_JAMWMK010000149.1 IMICODJL_01333 Prodigal:2.6 24687 24947 + VFG042985(gb|ACI49669) 86.0 6.42e-42 (ACI49669) hypothetical hydrophobic peptide VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKWFKLLLFNLSCLIAVFLYWGLLFSQLSILPRYQPYLMRIFSIPAASMPLDIMEKLIRNPLFITANLIVVVGISLVIYKKEGMKG Kraken2_NZ_JAMWMK010000149.1 IMICODJL_01334 Prodigal:2.6 24944 27013 + VFG042984(gb|ACI49668) 76.4 0.0 (ACI49668) minor pilin subunit VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MNFKHSWTRRLKYVFPIMMMLGTLFGLKTTNVFAEKVIVDPSNPIQNVKNNFIIPKDVPNANATIKVYDSGYVQKKHLAANQGSAWGNINYLTDNNIALNTRYPSFQKNYGQTSLIIDNVTSKTRIEADYGKIATYKGEKVNVKLVFSDIKLLSDEFPFATLGDPYKAAFNNANSSISKSKKRLLFYISDNLYSGFHYHASQMNVQLVVTHDDGSPVIFDGDTFISFNSLNPIAKNSNNTQRGEYAYYHGMNNSDWYVTKDTVLTEQKSYYNNLTVVGGNNKAPFDKGLYWNDHYDELGSEKFNQATVSFRIKGSNPLFVVGGNFATWSSLSSATLFSVVPDQPEKTGVNKDGNDVNNKVLQEGDTIQYRIKQKVNRLGVDLLAVYDRFELIDNLPKEVDYVDAHVECGSNKKFDVSGEVTYDKTKHQVKYAAKADTLKNRMKYNGETYELVINVKVNELANQNSVAKNQGTSIINKVEMDTNIITVYFPKIPVKEVQQDGKDVNGRNDGKKGTPTAPLNAGSEVQYLVTQKWHTKGVDAASDHYKQFSIQDPIEARLTYKEGSAQVIDKSTGKDITSEGTLTYDSNSRTLKWEASANFLSNNLLDGREIQLIFTAKTPLQSEKNIDNQAVVAVDNVSNKTNVVTIGVDPNLPQVIVPKTGSTHLVTTLVVSLLLLVLATFSYVVLKFN Kraken2_NZ_JAMWML010000157.1 IMICODJL_01451 Prodigal:2.6 12882 13856 - VFG019385(gb|WP_003728858) 75.6 1.64e-185 (bsh) bile salt hydrolase VF0350 BSH VFC0282 Stress survival The bsh gene is positively regulated by the central listerial virulence regulator PrfA in vivo Involved in resisting the acute toxicity of bile and bile salts, important for intestinal persistence of L. monocytogenes Bile salts are the end products of the cholesterol metabolism in the liver and are stored in the gall bladder and released into the duodenum, helping fat digestion. In addition, bile salts are known to have antimicrobial activity since they are amphipathic molecules which can attack and degrade lipid membranes. BSH can transform and inactive the bile salts by catalyzing the hydrolysis of the amide bond, liberating the glycine/taurine moiety from the side chain of the steroid core. MCTAITYTTKNNYFGRNFDYEISYNEKVVITPRNFPFKFRKVNDINQHYAFIGVATVVDDYPLYYDATNEKGLSIAGLNFEGNAYYGEEVKGKLNIAPFEFIPWILGQCSTIKEVKKLLEQINFVNINFSEKLPLSPLHWLVADKNESIVIENLKTGLKIYDNPVGVLTNNPTFDYQLFNLNNYQNLSTQTPNNLFSKNINLNSYSRGMGGLGLPGDLSSMSRFVKATFTKLNSVSGDSESESISQFFHILGSVEQQKGLCDVGGKNYEYTIYSSCCNIDRGIYYYKTYENSQITAVDMNKEDLESSTLFTYNLINNQIINYLN Kraken2_NZ_JAMWML010000157.1 IMICODJL_01461 Prodigal:2.6 22850 26701 + VFG050211(gb|WP_010968279) 97.7 0.0 (cna) collagen adhesin VF0730 Cna VFC0001 Adherence MQVDAGIETILYWGYPAKDGSDWGISADEYRYCTQLAIWAYQKEAGLSRGLVRERLQSGTVPLSKLKPVIDFLVDKAHNKEMPTFFEVSPNDIIAHQEGDYFVSEQIKIKSNYTLSGVKVTIKSASNSELTKDIVIKDMDGNVKDSGYKANESFRVYIPSNAETGDLKVSVKAKVDIPAMLGYMTPEQGIQDMAVSSLDTHSMDKDNIKVSWTGLNGAVQVIKKGDDGKLLTGAKFVLKNASGENVAEATSQDGKAVFNDIKPAEYTIHEVEAPQGYLVTNPVNVTVKPNKVSIAEMTDTQIKGKIQVLKVDEETNTPLQGAEFEITQDGKHIETITTGENGIATSSLLPFGNYLVKEIKAPAKYVLNGEEHPVTISENGKTIEITHTNKIIKGKVAVKKTDSEIADLNLEGAEFTIYDNNKNIVATITTNKDGYAESEPLNYGTYTMQETKAPKGYLLSNKVWDINITEDGKVYSYDITNDVIKGKLQIVKVDSENEEKPVEGAGFDVIAVNVNGIKEGTVVDHVVTDKNGFAYTKDLRYGDYKFHETDTPKGYWKSDKEYSFSITENGKTYVKYVKNSPIQAKVRVIKVDSKDGKPLKGVKFQIRNTDTKKLVEFTNFIGIIPMKTTTLETNKNGELVTPQNLAYGNYLLEEVEPLEGYIKVNPIPFKIDENSVLEEIKDLGTIYTQKVSNDRITANMELLKLDKETNKPLENIEFKVTALDGFMKGKTWNLKSDDKGLVSLKGLEYGNYRVDEVKTLWNYVLNKEPIFFSVKENGKTIKLQMTNKKIRGSVELFKFDKDTNRPLEGVKFDLLNGDKKVGTYTTDNTGKITVNNLEAGNYTWVEVEAIDHYNKVDKKYDFNIYKDGQLEKIDVANTVKTGELDFTKTDVTTGDTIDGAKVKITGLEPQNKHINIEFTSSKEGNKFTLPEGKYTFEETLAPEGYRINKEVGTFEIKDGQITKANLKDERKQGDLIFTKTDVTTGKVIEGAKIKITCIEGLSKGKVIEFTSSKNGNKFTLDEGKYTFEETSAPNGYRINKEVGTFEIKDGEITKANLKDERKQGNLEFTKTDVTDGRIIEGAKIKIICVEGLSKGKVIEFTSFKDGNKFTLDEGKYTFEEISAPNGYEINKEVGTFEIKDGEITKANLKDERTTGVLEFTKTDIATGEVLEGAHIKIECLEGLDQGKVIEFTSSKEGNKFTLAKGKYRISETKAPEGYELTTETGEFEITNKGDIITCNLTNKKIEIVKTGNSFDINSLIPLGILLVAGGIGGLFFTKKRKLS Kraken2_NZ_JAMWML010000158.1 IMICODJL_01483 Prodigal:2.6 297 2807 - VFG050211(gb|WP_010968279) 92.3 0.0 (cna) collagen adhesin VF0730 Cna VFC0001 Adherence MQETKAPKGYLLSNKVWDINITEDGKVYSYDITNDVKKGKLQIVKVDSENEEKPVEGAGFDVIAVNVNGIKEGTVVDHVVTDKNGFAYTKDLRYGDYKFHETDTPKGYWKSDKDYSFSITENGKTYVKYVKNSPIQAKVRVIKVDSKDGKPLKGVKFQIRNTDTKKLVEFTNFIGIIPYKTTTLETNKNGELVTPQNLAYGNYLLEEVEPLEGYIKVNPIPFKIDENAVLEEIKELGTIYTQKVSNDRITANMELLKLDKETNKPLAKIEFKVTALDGFMKGKTWDLKSDNKGLVSLKGLEYGNYRVDEVKTLWNYVLNKEPIFFSVKENGKTIKLQMTNKKIRGSVELFKFDKDTNRPLEGVKFDLLNGDKKVGTYTTDNTGKITVNNLEAGNYTWVEVEAIDHYNKIDKKYDFNIYKDGQLEKIDVANTIKTGELDFTKTDVTTGDTIDGAKVKITGLEPQNKHINIEFTSSKEGNKFTLPEGKYTFEETLAPEGYRINKEVGTFEIKDGQITKANLKDERKQGDLIFTKTDVTTGKVIEGAKIKITCIEGLSEGKVIEFTSSKDGNKFTLDEGKYTFEEILAPNGYRINKEIGTFEIKDGEITKANLKNERKQGDLEFTKTDVTTGKVIEGAKIKITCIEGLSEGKVIEFTSFNDVNKFTLDEGKYTFEEISAPNGYEINKEVGTFEIKDGQITKANLKDERTTGVLEFTKTDAATGEVLEGAKIKIECLEGLDQGKVIEFTSSKEGNKFTLAKGKYRISETQAPNGYELTNETGEFEINEQGQVVKCNLTNKKFEIVKTGSNFDFNSLLPLGLVLVVGGLGALTLTRKRKNA Kraken2_NZ_JAMWML010000160.1 IMICODJL_01486 Prodigal:2.6 302 2539 - VFG050211(gb|WP_010968279) 82.6 0.0 (cna) collagen adhesin VF0730 Cna VFC0001 Adherence MQETKAPKGYLLSNKVWDINITEDGKVYSYDITNDVIKGKLQIVKVDSENEEKPVEGAGFDVIAVNVNGIKEGTVVDHVVTDKDGFAYTKDLRYGDYKFHETDTPKGYWKSDKEYSFSITENGKTYVKYVKNSPIQAKVRVIKIDSKDGKPLKGVKFQIRNTDTKKLVEFTNFIGIIPMKTTTLETNKNGELVTPQNLAYGNYVLEEVEPLEGYIKANPIPFKIDENSVLEEIKDLGTIYTQKVSNDRITANMELLKLDKETNKPLENIEFKVTALDGFMKGQTWNLKSDDKGLVSLKGLEYGNYRVDEVKTRWNYVLNKEPIFFSVKENGKTIKLQMTNKKIRGSVELFKFDKDTNRPLEGVKFDLLNGDKKVGTYTTDNTGKITVNNLEAGNYTWVEVEAIDHYNKVDKKYDFNIYKDGQLEKIDVANTVKTGELDFTKTDVTTGDTIDGAKVKITGLEPQNKHINIEFTSSKEGNKFNLPEGKYTFEETLAPEVYRINKEVGAFEIKDGQITKANLKDERKQGDLIFTKTDVTTGKVIEGAKIKITCIEGLDQGKVIEFTSFNDVNRFTLDEGKYTFEEISAPNGYEINKEVGIFEIKDGQITKANLKDERTTGVLEFTKTDVATGEILDGAKIKIECLEGLDQGKVIEFTSSKEGNKFTLAKGKYRISETQAPNGYELTTETGEFEINEQGQVVKCNLTNKKFEIVKTGSSFDFNSLLPLGLVLVVGGLGALTLTRKRKNA Kraken2_NZ_JYFG01000065.1 IMICODJL_01650 Prodigal:2.6 2700 4886 - VFG038363(gb|WP_005321178) 100.0 0.0 (aopO) Type III secretion system effector AopO, putative serine/threonine kinase VF0652 T3SS secreted effectors VFC0086 Effector delivery system AexT (ADP-ribosyltransferase. Induces morphological changes in fish cells, including cell rounding and subsequent lysis. ); AopH; AopO; Ati2 (Putative inositol phosphatase. ) MKIIGTTTPSITLSQAHERAANHGQHPVGELNIEGKRYRIVDNQVLRLNPHGGIARFREGVGKLFSGQAPDTSYARALTETLHAACKAAPKSPGGEAPQEIGGLFGLKPQTTLLLGWKGEPLPGAPSLEGMRVAETDKFAEGESHISIVETHDKQRLVAKIERSVAEGHLQGELEAYQHIYQSAGKHPNLGNVHGMAVVPYGSRKEEALLMDEVDGWRCSDTMRTLTDHWKQGKVSSEEYWGTVKFIAHRLLDVTGHLAKAGIVHNDIKPGNVVFDKHSGEPVVIDLGLHSRPGEQPKGFTDSFKAPELAIGSPLASEKSDLFLVVSTLLHGIEGFERDLERKPNQGLSLTRGTAHRLDERGNPVHRPGVAGVETAYTRFVDQIIGAPAEQRPDSAEARLHEFLSDGTIDEGRARQILKETLSGELAASPADARRVTPRKIRELSDTLRLHLSSASTRQLNVGMALSDLAAMSAVLDKAERQEFADQGQIKSFNSLILKGYGVIASYVKGELDESKTPQGEPSPQLSGNIMKSVAEPTLKQIQGQLAQSHGLVDIATLERSRQHLETLLTVLFPSSPQEKVSPEVYDFLYRVAEVKGSLGVRLDGLKGQQQRVRSELSTLMRAVTAWAGDARQALQRFDSIRPVVKFGSVQDMAVHRSMIAAYAATTLQEVAGFAGEMRHFAAAATPLLTQLGRSTLADEGLTFQREQLRELVTVAERLNRLSQEWIR Kraken2_NZ_JYFG01000065.1 IMICODJL_01651 Prodigal:2.6 4893 5612 - VFG038362(gb|WP_005321180) 100.0 1.82e-102 (sycO) AopO chaperone VF0479 T3SS VFC0086 Effector delivery system Similar to the Yersinia T3SS "A needle-like structure, often described as an ""injectisome"" that can inject effectors directly into the cytoplasm of target cells; five effectors have been described: AexT, AexU, AopP, AopH and AopO; AexT and AexU are bifunctional toxins that contain a GTPase activating domain, allowing the interruption of host cell-signalling pathways and an ADP-ribosylating domain that can disrupt the host cytoskeleton, leading to the induction of apoptosis; AopP (NF-kappaB inhibitor), AopH (tyrosine phosphatase) and AopO (serine/threonine kinase), all are able to interrupt host cell signalling pathways and induce toxicity" MSQRSRQNDKREHLAHIDALLQDAIRQWQPEQPRRWLAKYGGWAFESFGSAARQSRRPLVPKFAAVSDICGARFHQSWAGLTTQPTTRLKGPCMTTTAVTGLFQEIAHQLGLETLSQDEHGLCELILNDRIVIMLRADESLQRLTLLGPVSGMTGPEAKEAACRLWMGHSIAALTHDGPHLAWSEEQGLITFCHLAFHGLNAERVCQALAGLFEWLSQAAGEERSQDGQQAQVTSASWV Kraken2_NZ_JYFG01000080.1 IMICODJL_01683 Prodigal:2.6 2511 2936 - VFG038358(gb|WP_005321603) 100.0 1.67e-99 (sycH) AopH chaperone SycH VF0479 T3SS VFC0086 Effector delivery system Similar to the Yersinia T3SS "A needle-like structure, often described as an ""injectisome"" that can inject effectors directly into the cytoplasm of target cells; five effectors have been described: AexT, AexU, AopP, AopH and AopO; AexT and AexU are bifunctional toxins that contain a GTPase activating domain, allowing the interruption of host cell-signalling pathways and an ADP-ribosylating domain that can disrupt the host cytoskeleton, leading to the induction of apoptosis; AopP (NF-kappaB inhibitor), AopH (tyrosine phosphatase) and AopO (serine/threonine kinase), all are able to interrupt host cell signalling pathways and induce toxicity" MTEQFDAAVAALGQHLGLTLTTTEGIASLTLDGSHTIHLAPLGNSQLSLFMRLAPLKDAEQAITLLQQNLFSADPFSPRMALSPDLYLILWSQHPASSMDGSSLYQALTLLHNHAQRWLCHQSEGDSPTADESHPAPILRV Kraken2_NZ_JYFG01000080.1 IMICODJL_01684 Prodigal:2.6 3133 4524 + VFG038359(gb|WP_005321607) 100.0 0.0 (aopH) Type III secretion system effector AopH, putative tyrosine phosphatase VF0652 T3SS secreted effectors VFC0086 Effector delivery system AexT (ADP-ribosyltransferase. Induces morphological changes in fish cells, including cell rounding and subsequent lysis. ); AopH; AopO; Ati2 (Putative inositol phosphatase. ) MNLTIQTLHQQVSRLAEQQNGELIGKLRGNVAANREGSFQGLTVTNGARDTEKAFAQEVLRHVQDIALNQDDVAALHKSAIRFNHNNFELRSIGNSQSQLVGLRSDQLTLKDAKTLLDAAMRQQGAQHHAASAPAGQDAPPLPPRRAPALPPHNAGPALAQQHERLRSAAPRMVTPAAVEPYGAQTKRELSSRLAGLQQQLQPSVQPDRYLQSPDGSKLNRFRDIQANKATAVRADLNANYVQAGAHRSIACQYPLESQLESHLQMLFDNRTPVLAVLASAHEIANPQFNMPNYFRQNGQYGAMSVTSTHKESIDLGDGIQADVYQMALTMPGSGKKGIAVPVVHVSNWPDKTAVSAEVTEQLSALLEQKAQEKRAIYEKAGSSAVGDANKLLPVVHCRAGVGRTAQVIGSMAMHDPRNAALSMEEVVSDMRTSRNGVMVQKQEQLDVLMTLADRQQRPLLRA Kraken2_NZ_LUAX01000008.1 IMICODJL_01844 Prodigal:2.6 189431 189727 + VFG041187(gb|WP_012849267) 67.0 2.39e-36 (ETAE_RS11285) PAAR domain-containing protein VF1268 EVP (E. tarda virulent protein) VFC0086 Effector delivery system MLPAARATDMHVCPMQTPAVVPIPHVGGPLLPMPSTVLVGNLPVATLGQMCVCVGPPDSVVKGSATVLVNNKPAARMGDLTAHGGTIVMGMPTVLVGG Kraken2_NZ_LZCY01000052.1 IMICODJL_02180 Prodigal:2.6 5024 6409 + VFG034652(gb|WP_000074204) 72.3 1.79e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALNNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYNGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_LZCZ01000002.1 IMICODJL_02307 Prodigal:2.6 32605 33990 - VFG034652(gb|WP_000074204) 72.3 1.79e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALNNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYNGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_LZCZ01000002.1 IMICODJL_02373 Prodigal:2.6 98603 99748 - VFG043568(gb|NP_460531) 62.8 1.21e-159 (nmpC) phosphoporin PhoE VF0969 OmpD VFC0001 Adherence MKRKVLALMVPALLMASAANAAEIYNKNGNKLDLYGKVDGLHYFSDDASEDGDQTYVRFGLKGETQITSELTGYGQWEYNIQANTSEKEGANSWTRLGFAGLKFADCGSLDYGRNYGVVYDIESWTDMLPEFGGDTYTQTDVYMTGRTNGVATYRNSDFFGLVDGLHFALQYQGNNENAGSGEGTNNGGKRKLARENGDGFGISSYYDLDMGISFGAAYSSSDRTHNQLAAARSSQRYANGDKADAWTVGAKYDANNIYLAAMYAETRNMTFYGNDSFGGIANKTQNFEVVAQYQFDDFNLPLRPSVAYLQSKGKDLYAYSRYGDKDLVKYVDVGMTYYFNKNMSTYVDYKINLLDEDDRFYKNSGIATDDIVALGLVYQF Kraken2_NZ_MAOP01000003.1 IMICODJL_02572 Prodigal:2.6 12294 13679 + VFG034652(gb|WP_000074204) 72.3 1.79e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALNNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYNGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_JANPXM010000002.1 IMICODJL_03516 Prodigal:2.6 76224 77246 + VFG013197(gb|WP_011608705) 66.5 1.41e-154 (hemB) porphobilinogen synthase VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MSIIIPGSFPARRLRRSRTHSFSRRLVAENQLTVNDLILPVFIIEGQNLRQEVPSMPGVFRLSVDMLLHDAAQFVQAGIPAIALFPCIESSAKSLMADASWDPSGLVPRTVRALKKAFPELGVITDVALDAYTSHGQDGIIDEHGYVLNEPTKEILTRQALTHAEAGADIVAPSDMMDGRIGHIRQAFETNGLLTIQIMAYSAKYASNYYGPFREATQSAMALGKRDKKNYQMDPANAMEALHEIAQDLQEGADMVMVKPGMPYLDIIREARKTFAVPVFAYQVSGEYAMHMAAFRHGWLDEEQTVLESLICFKRAGADGILTYFASSVAQWLNQHQREY Kraken2_NZ_JANPXM010000002.1 IMICODJL_03534 Prodigal:2.6 86847 88166 + VFG048547(gb|WP_004213617) 99.8 0.0 (iroN) salmochelin receptor IroN VF0563 Sal Salmochelin VFC0272 Nutritional/Metabolic factor Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection Inducing dissemination through chelation of host cellular iron, leading to inactivation of iron-dependent prolyl hydroxylases and the master transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) stabilization in lung epithelial cells. HIF-1alpha controls vascular permeability and inflammatory gene expression MFAPSLAKSRKETNRLYRQNYGIAHNGIWDWGQSRFGVYYEKTNNNRMNEGLSGGSEGRILADEKFTTNRLSSWRTSGEINIPLNEPVDQTLTVGVEWSRDKLDAPSSTSLTVNDSDIGGISGSAADRSSKNHSQISALYIDDNIEPVPGTNIISGLRFDYLNESGGNFSPSLNLSQELGDYFKVKAGIARTFKAPNLYQSSKGYLLYSKGNGCPKDITSGGCYLKGNKDLDPEISINKEIGLEFAWEDYYASVTYFRNDYQNKIVAGDNAIGQTASGAYILQWQNGGKALVDGIEASMAFPLVKDRLNWNTNATWMITSEQKDTGNPLSIIPKYTINNSLDWTITQAFSASVNWTLYGRQKPRTHAESRSEDTRGMSGKVLGAYSLVGTNFNYDINKNLRLNIGVSNILDKQIYRTSEGASTYNEPGRAYYVGAVVSF Kraken2_NZ_JANPXM010000002.1 IMICODJL_03538 Prodigal:2.6 90499 91086 - VFG048996(gb|WP_004213609) 99.5 7.77e-146 (rmpA) regulator of mucoid phenotype RmpA VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MLTDDYFFYYGLKQLTGLPLFHITYEGVVNKSIAIKHKRNIRVLVDSRIFYSGKWGGYKMLRGSLNMISQWMWLDVSGGGRFYPKGCDYDIYVNMQGNVKNNIEKLYFAFLKKNVSRIVNHYPRLTKKEQAVLQCLLKNGGINEIKSQLKIEEKTLSCYQSKITRKFGCKRYIRFMYLYSLNKEMVDERWLMPSI Kraken2_NZ_JANPXM010000002.1 IMICODJL_03561 Prodigal:2.6 109471 111252 + VFG048600(gb|WP_004213920) 100.0 0.0 (iucA) aerobactin Synthetase IucA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MGIFIDKILIIMTSEICLTMTLPTKTSTLDVAAQCFLNSLVRETKDWRLTEYQPTQLIIPLGEQQALHFRVAYFSPTQHHRFEFPARLVTASGSHPVDFATLSRLIVDKLQHQLLLPATSCETFHQRVMESHAHTQQAIDARHDWAALREKALNFGEAEQALLVGHAFHPAPKSHEPFNQQEAERYLPDFAPHFPLRWFAVNKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLHPWQGEYLLQQEWCQELVAKGLIKDLGEAGAPWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVKRGMRLARLAQTDDWQTLQARFPTFRVMQEDGWAGLRDLHGNIMQESLFALRENLLVDQPQSQTNVLVSLTQAAPDGGDSLLVAAVKRLSDRLGITAQQAAHAWVDAYCHQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGLIYRDCQGSAFMPHAAGWLDTIGEAQAENVFTREQLLRYFPYYLLVNSTFAVTAALGAAGLDSEANLMARVRTLLAEMRDQVTHKTCLNYVLENPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLLAQEG Kraken2_NZ_JANPXM010000002.1 IMICODJL_03562 Prodigal:2.6 111253 112200 + VFG048603(gb|WP_004213921) 100.0 2.6100000000000003e-248 (iucB) N-acetyltransferase IucB VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MSKANIVHSGYGLRCEKLDKPLNLSWGLDNSAVLHWPGPLPTGWLRDALEQIFIAAPQLSAVVLPWAEWREEPQALTLFGQVKSDIIHRTAFWQLPLWLSSPANRASGEMVFDAEREIYFPLRPPRPQGEVYRRYDPRVRKTLSFRVADPVLDAERFTRWMNDPRVEYFWEQSGSLEVQTAYLERQLTGKHAFPLIGCFDDRPFSYFEIYWAAEDRIGRHYSWQPFDRGLHLLVGEQQWRGAHYVQSWLRGLTHYLLLDEPRTQRTVLEPRADNQRLFRHLEPAGYRTIKEFDFPHKRSRMVMADRHHFFTEVGL Kraken2_NZ_JANPXM010000002.1 IMICODJL_03563 Prodigal:2.6 112200 113933 + VFG048606(gb|WP_004213922) 100.0 0.0 (iucC) aerobactin siderophore biosynthesis protein IucC VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MNHKDWDFVNRQLVAKMLAELEYEQVFHAESQGDGRYCINLPGAQWRFSAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKPVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLIDLDADRLQCLLSGHPKFAFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMVWRCDSELDIQQLLAAAMDPQEFARFNQVWQDNGLDNDWLPLPVHPWQWQQKISLDFIADLAEGRMVSLGEFGDLWLAQQSLRTLTNASRQGGLDIKLPLTIYNTSCYRGIPGKYIAAGPLASRWLQQVFATDATLKQSGAVILGEPAAGYVSHEGYAALAQAPYRYQEMLGVIWRENPCRWLKPDESPILMATLMECDENNQPLIGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKKGVPQRVLLKDFQGDMRLVKDAFPEMDSLPQEVRDVTARLSADYLIHDLQTGHFVTVLRFVSPLMARLGVPERRFYQLLAAVLSDYMQEHPQMSARFALFSLFKPQIIRVVLNPVKLTWHDQDGGSRMLPNYLEDLQNPLWLATRD Kraken2_NZ_JANPXM010000002.1 IMICODJL_03564 Prodigal:2.6 113937 115214 + VFG048609(gb|WP_004213923) 100.0 0.0 (iucD) lysine 6-monooxygenase IucD VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MTNTVDFIGIGIGPFNLSIAALSHQAEGLSSRFFDGRPHFAWHPGMLVPDCHMQTMFLKDLVSAVAPTSPYSFVNYLVKRKKFYRFLTTELRTVSRDEFSDYLRWAAEGMNNLHFNHTVESIDFDERHQRFVVQTSQGESVARNICLGIGKQPHLPPCVKTATQTCFHASEMSLRRPDLGGKRVSVVGGGQSGADLFLNALRGEWGDVAEISWVSRRNNFNALDEAAFANEYFTPEYVSGFVGLNERARQKMLDEQKMTSDGITADSLLTIYRELYHRFEVLRQPRNARLLPSRSVTGLESRGQSWQLLLEHHLDNGYDTLESDVVIFATGYRPALPQILSPLMSRIAMRDECNFKVRDDFTLEWNGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARILNRVMGRDLFDLSMPPALIQWRSGT Kraken2_NZ_JANPXM010000002.1 IMICODJL_03565 Prodigal:2.6 115299 117497 + VFG048621(gb|WP_004213924) 100.0 0.0 (iutA) ferric aerobactin receptor IutA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNIDRIEVISGATSLYGGGSTGGLINIVTKKGQPETIMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTERHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAAFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIAAGKATSADAIPGGSVDYDNFLFNAGLLMHITERQQAWLNFSQGVELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTVDLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF Kraken2_NZ_JANPXM010000002.1 IMICODJL_03575 Prodigal:2.6 122722 123021 - VFG048998(gb|WP_011154608) 100.0 5.3499999999999995e-68 (rmpA2) regulator of mucoid phenotype RmpA2 VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MEKYIYFMCNKDVTLVLTDDYYFYFGLKQLTGLPLVYITYEGSMDKPIVIKQKRNIRVLVDSRIFYSGKWDGYKMLRKTLNMISQWMWLDISGGGEVLS Kraken2_NZ_JANPXM010000003.1 IMICODJL_03762 Prodigal:2.6 79781 81166 - VFG034652(gb|WP_000074204) 72.3 7.28e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSSVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_JANPXL010000002.1 IMICODJL_03963 Prodigal:2.6 94528 95550 + VFG013197(gb|WP_011608705) 66.5 1.41e-154 (hemB) porphobilinogen synthase VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MSIIIPGSFPARRLRRSRTHSFSRRLVAENQLTVNDLILPVFIIEGQNLRQEVPSMPGVFRLSVDMLLHDAAQFVQAGIPAIALFPCIESSAKSLMADASWDPSGLVPRTVRALKKAFPELGVITDVALDAYTSHGQDGIIDEHGYVLNEPTKEILTRQALTHAEAGADIVAPSDMMDGRIGHIRQAFETNGLLTIQIMAYSAKYASNYYGPFREATQSAMALGKRDKKNYQMDPANAMEALHEIAQDLQEGADMVMVKPGMPYLDIIREARKTFAVPVFAYQVSGEYAMHMAAFRHGWLDEEQTVLESLICFKRAGADGILTYFASSVAQWLNQHQREY Kraken2_NZ_JANPXL010000002.1 IMICODJL_03981 Prodigal:2.6 105151 106470 + VFG048547(gb|WP_004213617) 99.8 0.0 (iroN) salmochelin receptor IroN VF0563 Sal Salmochelin VFC0272 Nutritional/Metabolic factor Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection Inducing dissemination through chelation of host cellular iron, leading to inactivation of iron-dependent prolyl hydroxylases and the master transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) stabilization in lung epithelial cells. HIF-1alpha controls vascular permeability and inflammatory gene expression MFAPSLAKSRKETNRLYRQNYGIAHNGIWDWGQSRFGVYYEKTNNNRMNEGLSGGSEGRILADEKFTTNRLSSWRTSGEINIPLNEPVDQTLTVGVEWSRDKLDAPSSTSLTVNDSDIGGISGSAADRSSKNHSQISALYIDDNIEPVPGTNIISGLRFDYLNESGGNFSPSLNLSQELGDYFKVKAGIARTFKAPNLYQSSKGYLLYSKGNGCPKDITSGGCYLKGNKDLDPEISINKEIGLEFAWEDYYASVTYFRNDYQNKIVAGDNAIGQTASGAYILQWQNGGKALVDGIEASMAFPLVKDRLNWNTNATWMITSEQKDTGNPLSIIPKYTINNSLDWTITQAFSASVNWTLYGRQKPRTHAESRSEDTRGMSGKVLGAYSLVGTNFNYDINKNLRLNIGVSNILDKQIYRTSEGASTYNEPGRAYYVGAVVSF Kraken2_NZ_JANPXL010000002.1 IMICODJL_03985 Prodigal:2.6 108803 109390 - VFG048996(gb|WP_004213609) 99.5 7.77e-146 (rmpA) regulator of mucoid phenotype RmpA VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MLTDDYFFYYGLKQLTGLPLFHITYEGVVNKSIAIKHKRNIRVLVDSRIFYSGKWGGYKMLRGSLNMISQWMWLDVSGGGRFYPKGCDYDIYVNMQGNVKNNIEKLYFAFLKKNVSRIVNHYPRLTKKEQAVLQCLLKNGGINEIKSQLKIEEKTLSCYQSKITRKFGCKRYIRFMYLYSLNKEMVDERWLMPSI Kraken2_NZ_JANPXL010000002.1 IMICODJL_03993 Prodigal:2.6 115735 116322 - VFG048996(gb|WP_004213609) 99.5 7.77e-146 (rmpA) regulator of mucoid phenotype RmpA VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MLTDDYFFYYGLKQLTGLPLFHITYEGVVNKSIAIKHKRNIRVLVDSRIFYSGKWGGYKMLRGSLNMISQWMWLDVSGGGRFYPKGCDYDIYVNMQGNVKNNIEKLYFAFLKKNVSRIVNHYPRLTKKEQAVLQCLLKNGGINEIKSQLKIEEKTLSCYQSKITRKFGCKRYIRFMYLYSLNKEMVDERWLMPSI Kraken2_NZ_JANPXL010000002.1 IMICODJL_04016 Prodigal:2.6 134714 136495 + VFG048600(gb|WP_004213920) 100.0 0.0 (iucA) aerobactin Synthetase IucA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MGIFIDKILIIMTSEICLTMTLPTKTSTLDVAAQCFLNSLVRETKDWRLTEYQPTQLIIPLGEQQALHFRVAYFSPTQHHRFEFPARLVTASGSHPVDFATLSRLIVDKLQHQLLLPATSCETFHQRVMESHAHTQQAIDARHDWAALREKALNFGEAEQALLVGHAFHPAPKSHEPFNQQEAERYLPDFAPHFPLRWFAVNKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLHPWQGEYLLQQEWCQELVAKGLIKDLGEAGAPWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVKRGMRLARLAQTDDWQTLQARFPTFRVMQEDGWAGLRDLHGNIMQESLFALRENLLVDQPQSQTNVLVSLTQAAPDGGDSLLVAAVKRLSDRLGITAQQAAHAWVDAYCHQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGLIYRDCQGSAFMPHAAGWLDTIGEAQAENVFTREQLLRYFPYYLLVNSTFAVTAALGAAGLDSEANLMARVRTLLAEMRDQVTHKTCLNYVLENPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLLAQEG Kraken2_NZ_JANPXL010000002.1 IMICODJL_04017 Prodigal:2.6 136496 137443 + VFG048603(gb|WP_004213921) 100.0 2.6100000000000003e-248 (iucB) N-acetyltransferase IucB VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MSKANIVHSGYGLRCEKLDKPLNLSWGLDNSAVLHWPGPLPTGWLRDALEQIFIAAPQLSAVVLPWAEWREEPQALTLFGQVKSDIIHRTAFWQLPLWLSSPANRASGEMVFDAEREIYFPLRPPRPQGEVYRRYDPRVRKTLSFRVADPVLDAERFTRWMNDPRVEYFWEQSGSLEVQTAYLERQLTGKHAFPLIGCFDDRPFSYFEIYWAAEDRIGRHYSWQPFDRGLHLLVGEQQWRGAHYVQSWLRGLTHYLLLDEPRTQRTVLEPRADNQRLFRHLEPAGYRTIKEFDFPHKRSRMVMADRHHFFTEVGL Kraken2_NZ_JANPXL010000002.1 IMICODJL_04018 Prodigal:2.6 137443 139176 + VFG048606(gb|WP_004213922) 100.0 0.0 (iucC) aerobactin siderophore biosynthesis protein IucC VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MNHKDWDFVNRQLVAKMLAELEYEQVFHAESQGDGRYCINLPGAQWRFSAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKPVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLIDLDADRLQCLLSGHPKFAFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMVWRCDSELDIQQLLAAAMDPQEFARFNQVWQDNGLDNDWLPLPVHPWQWQQKISLDFIADLAEGRMVSLGEFGDLWLAQQSLRTLTNASRQGGLDIKLPLTIYNTSCYRGIPGKYIAAGPLASRWLQQVFATDATLKQSGAVILGEPAAGYVSHEGYAALAQAPYRYQEMLGVIWRENPCRWLKPDESPILMATLMECDENNQPLIGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKKGVPQRVLLKDFQGDMRLVKDAFPEMDSLPQEVRDVTARLSADYLIHDLQTGHFVTVLRFVSPLMARLGVPERRFYQLLAAVLSDYMQEHPQMSARFALFSLFKPQIIRVVLNPVKLTWHDQDGGSRMLPNYLEDLQNPLWLATRD Kraken2_NZ_JANPXL010000002.1 IMICODJL_04019 Prodigal:2.6 139180 140457 + VFG048609(gb|WP_004213923) 100.0 0.0 (iucD) lysine 6-monooxygenase IucD VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MTNTVDFIGIGIGPFNLSIAALSHQAEGLSSRFFDGRPHFAWHPGMLVPDCHMQTMFLKDLVSAVAPTSPYSFVNYLVKRKKFYRFLTTELRTVSRDEFSDYLRWAAEGMNNLHFNHTVESIDFDERHQRFVVQTSQGESVARNICLGIGKQPHLPPCVKTATQTCFHASEMSLRRPDLGGKRVSVVGGGQSGADLFLNALRGEWGDVAEISWVSRRNNFNALDEAAFANEYFTPEYVSGFVGLNERARQKMLDEQKMTSDGITADSLLTIYRELYHRFEVLRQPRNARLLPSRSVTGLESRGQSWQLLLEHHLDNGYDTLESDVVIFATGYRPALPQILSPLMSRIAMRDECNFKVRDDFTLEWNGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARILNRVMGRDLFDLSMPPALIQWRSGT Kraken2_NZ_JANPXL010000002.1 IMICODJL_04020 Prodigal:2.6 140542 142740 + VFG048621(gb|WP_004213924) 100.0 0.0 (iutA) ferric aerobactin receptor IutA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNIDRIEVISGATSLYGGGSTGGLINIVTKKGQPETIMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTERHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAAFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIAAGKATSADAIPGGSVDYDNFLFNAGLLMHITERQQAWLNFSQGVELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTVDLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF Kraken2_NZ_JANPXL010000002.1 IMICODJL_04030 Prodigal:2.6 147965 148264 - VFG048998(gb|WP_011154608) 100.0 5.3499999999999995e-68 (rmpA2) regulator of mucoid phenotype RmpA2 VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MEKYIYFMCNKDVTLVLTDDYYFYFGLKQLTGLPLVYITYEGSMDKPIVIKQKRNIRVLVDSRIFYSGKWDGYKMLRKTLNMISQWMWLDISGGGEVLS Kraken2_NZ_JANPXL010000003.1 IMICODJL_04163 Prodigal:2.6 50240 51625 - VFG034652(gb|WP_000074204) 72.3 7.28e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSSVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_JANPYK010000002.1 IMICODJL_04374 Prodigal:2.6 19810 22008 - VFG033944(gb|WP_000973519) 100.0 0.0 (iutA) ferric aerobactin receptor precusor IutA VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNIDHIEVISGATSLYGGGSTGGLINIVTKKGQPETMMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTERHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAAFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIAAGKATSADAIPGGSVDYDNFLFNAGLLMHITERQQAWLNFSQGVELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTVDLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF Kraken2_NZ_JANPYK010000002.1 IMICODJL_04375 Prodigal:2.6 22093 23370 - VFG033958(gb|WP_000750130) 100.0 0.0 (iucD) L-lysine 6-monooxygenase IucD VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MKKSVDFIGVGTGPFNLSIAALSHQIEELDCLFFDEHPHFSWHPGMLVPDCHMQTVFLKDLVSAVAPTNPYSFVNYLVKHKKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVENIDFDKKRRLFLVQTSQGEYFARNICLGTGKQPYLPPCVKHMTQSCFHASEMNLRRPDLSGKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISGFSGLEEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLESSGPGWKLLMEHHLDQGRESLESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDDFTLEWSGPKENNIFVVNASMQTHGIAEPQLSLMAWRSARILNRVMGRDLFDLSMPPALIQWRSGT Kraken2_NZ_JANPYK010000002.1 IMICODJL_04376 Prodigal:2.6 23367 25109 - VFG012522(gb|WP_001015721) 100.0 0.0 (iucC) aerobactin siderophore biosynthesis protein IucC VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MNHKDWDLVNRRLVAKMLSELEYEQVFHAESQGDDRYCINLPGAQWRFIAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKQVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLINLNADRLQCLLSGHPKFVFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMIWRCDNEMDIHQLLTAAMDPQEFARFSQVWQENGLDHNWLPLPVHPWQWQQKIATDFIADFAEGRMVSLGEFGDQWLAQQSLRTLTNASRRGGLDIKLPLTIYNTSCYRGIPGRYIAAGPLASRWLQQVFATDATLVQSGAVILGEPAAGYVSHEGYAALARAPYRYQEMLGVIWRENPCRWLKPDESPVLMATLMECDENNQPLAGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKEGVPQRVLLKDFQGDMRLVKEEFPEMDSLPQEVRDVTSRLSADYLIHDLQTGHFVTVLRFISPLMVRLGVPERRFYQLLAAVLSDYMKKHPQMSERFALFSLFRPQIIRVVLNPVKLTWPDLDGGSRMLPNYLEDLQNPLWLVTQEYES Kraken2_NZ_JANPYK010000002.1 IMICODJL_04377 Prodigal:2.6 25109 26056 - VFG033993(gb|WP_000011910) 99.7 5.26e-248 (iucB) aerobactin siderophore biosynthesis protein IucB VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MSGANIVHSGYGLRCEKLDKPLNLGWGLDNSAVLHWPGELPTGWLCDALDQIFIAAPQLSAVVLPWSEWCEEPQALTLFGQVQSDIIHRSAFWQLPLWLSSPANRASGEMVFDAEREIYFPQRPPRPQGEVYRRYDPRIRRMLSFRIADPVSDAERFTRWMNDPRVEYFWEQSGSLEVQIAYLERQLTSKHAFPLIGCFDDRPFSYFEIYWAAEDRIGRHYSWQPFDRGLHLLVGEQQWRGAHYVQSWLRGVTHYLLLNEPRTQRTVLEPRTDNQRLFRHLEPAGYRTIKEFDFPHKRSRMVMADRHHFFTEVGL Kraken2_NZ_JANPYK010000002.1 IMICODJL_04378 Prodigal:2.6 26057 27781 - VFG012526(gb|WP_000602863) 100.0 0.0 (iucA) aerobactin siderophore biosynthesis protein IucD VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MILPSEKSATDVAAQCFLNALIRETKDWQLAEYPPDELIIPLDEQKSLHFRVAYFSPTQHHRFAFPAHLVTASGSYPVDFTTLSRLIIDKLRHQLFLPVPLCETFHQRVLESYAHTQQTIDARHDWAILREKALNFGEAEQALLTGHAFHPAPKSHEPFNRQEAERYLPDMAPHFPLRWFSVDKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLHPWQGEYLLQQVWCQALFAKGLIRDLGEAGTSWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVERGMRLARLAQTDGWQMLQARFPTFRVMQEDGWAGLRDLNGNIMQESLFSLRENLLLEQPQSQTNVLVSLTQAAPDGGDSLLVSAVKRLSDRLGITVQQAAHAWVDAYCQQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGFIYRDCQGSAFMPHATEWLDTIDEAQAENIFTREQLLRYFPYYLLVNSTFAVTAALGAAGLDSEANLMARVRTLLAEVRDQVTHKTCLNYVLESPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLQAQEV Kraken2_NZ_JANPYK010000002.1 IMICODJL_04383 Prodigal:2.6 31113 31970 - VFG012590(gb|WP_000968139) 100.0 1.78e-190 (sitD) iron/manganese ABC transporter permease subunit SitD VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MMALLLEPLQFTFMSHALLISLVVSIPCALLSVFLVLKSWALMGDAMSHAVFPGIVLAWILGLPLATGAFVAGVFCAVATGYLKDNSRIKQDTVMGIVFSGMFAAGLILYIAVKPDVHLDHILFGDMLGITIGDIIQTVIIAGLVTLVISVKWRDFLLFSFDYQQAQASGLHTRWLHYGLLCMVSLTIVATLKAVGIILSISLLIAPGAIAVLLTQRFHIALLLATGISILVSMTGVWLSFFIDSAPAPTIVVLFAVMFIMTFTVTSINARTKENAEPRDLLSSD Kraken2_NZ_JANPYK010000002.1 IMICODJL_04384 Prodigal:2.6 31967 32824 - VFG012585(gb|WP_001101723) 100.0 1.48e-198 (sitC) iron/manganese ABC transporter permease subunit SitC VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MNVLLEPFSYEYMLNAMWVSAMVGGLCAFLSCYLMLKGWSLIGDALSHSIVPGVAGAYMLGLPFSLGAFFSGGLAAGSMLFLNQLTRLKEDAIIGLIFSSFFGLGLFMVSLNPTSVNIQTIVLGNILAIDPADILQLTIIGILSIIVLFFKWKDLMVTFFDENHARAIGLHPGRLKILFFTLLSVSTVAALQTVGAFLVICLVVTPGATAWLLTDRFPRLLMIAVTIGSVTSFLGAWVSYFLDGATGGIIVVAQTLLFLLAFVFAPTHGLLANRRRAHKALEDRS Kraken2_NZ_JANPYK010000002.1 IMICODJL_04385 Prodigal:2.6 32821 33645 - VFG034214(gb|WP_000983710) 100.0 3.3500000000000003e-192 (sitB) iron/manganese ABC transporter ATP-binding protein SitB VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MQSAGIVVNDVTVTWRNGHTALRDASFTVPGGSIAALVGVNGSGKSTLFKAIMGFVRLTSGKISVLGIPTRQALQKNLVAYVPQSEEVDWSFPVLVEDVVMMGRYGHMGMLRIAKKRDRQIVTDALERVDMVDFRHRQIGELSGGQKKRVFLARAIAQQGDVILLDEPFTGVDVKTEAKIISLLRELRAEGKTMLVSTHNLGSVTTFCDYTVMVKGTVLASGPTDTTFTAENLELAFSGVLRHVTLNGSEESIITDDERPFVAHRPSAVQREER Kraken2_NZ_JANPYK010000002.1 IMICODJL_04386 Prodigal:2.6 33648 34562 - VFG012575(gb|WP_000949004) 99.7 1.25e-220 (sitA) iron/manganese ABC transporter substrate-binding protein SitA VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MLSIKKVTMLLGCLVLTCSIAFQASAAEKFKVITTFTIIADMAKNVAGDAAEVSSITKPGAEIHEYQPTPGDIKRAQGVQLILANGMNLELWFQRFYQHLNGVPEVIVSSGVTPVGITEGPYEGKPNPHAWMSPDNALIYVDNIRDAFIKYDPANAQTYQRNADTYKAKITQTLAPLRKQIAELPENQRWMVTSEGAFSYLARDLGLKELYLWPINADQQGTPQQVRKVVDIVKKNHIPAVFSESTISDKPARQVARETGAHYGGVLYVDSLSTENGPVPTYIDLLKVTTSTLVQGIKAGKREK Kraken2_NZ_JANPYK010000003.1 IMICODJL_04548 Prodigal:2.6 12011 12697 - VFG001445(gb|AAA92657) 99.0 1.06e-145 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MCALDRRERPLNSQSVNKYILNVQNIYRNSPVPVCVRNKNRKILYANGAFIELFSREDKPLSGESYIRLQVEIFLSSLELECQALGHGSAFCRRFNFHGEIYQIRMENVSFYNDESVVLWQINPFPDYPFFALSQSGSNTNTSDKLTIWNDLSPGTLLVFSFYMLGVGHATIARELGITDRASEDRIKPVKRKIKEFFEHFDLFRVSCIYKGKIDLLLNIIREFYSVK Kraken2_NZ_JANPXN010000002.1 IMICODJL_04668 Prodigal:2.6 55406 56791 - VFG034652(gb|WP_000074204) 72.3 7.28e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSSVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_JANPXN010000002.1 IMICODJL_04695 Prodigal:2.6 72858 73880 - VFG013197(gb|WP_011608705) 66.5 1.41e-154 (hemB) porphobilinogen synthase VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MSIIIPGSFPARRLRRSRTHSFSRRLVAENQLTVNDLILPVFIIEGQNLRQEVPSMPGVFRLSVDMLLHDAAQFVQAGIPAIALFPCIESSAKSLMADASWDPSGLVPRTVRALKKAFPELGVITDVALDAYTSHGQDGIIDEHGYVLNEPTKEILTRQALTHAEAGADIVAPSDMMDGRIGHIRQAFETNGLLTIQIMAYSAKYASNYYGPFREATQSAMALGKRDKKNYQMDPANAMEALHEIAQDLQEGADMVMVKPGMPYLDIIREARKTFAVPVFAYQVSGEYAMHMAAFRHGWLDEEQTVLESLICFKRAGADGILTYFASSVAQWLNQHQREY Kraken2_NZ_JANPXN010000002.1 IMICODJL_04714 Prodigal:2.6 87789 89570 + VFG048600(gb|WP_004213920) 99.8 0.0 (iucA) aerobactin Synthetase IucA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MGIFIDKILIIMTSEICLTMTLPTKTSTLDVAAQCFLNSLVRETKDWRLTEYQPTQLIIPLGEQQALHFRVAYFSPTQHHRFEFPARLVTASGSHPVDFATLSRLIVDKLQHQLLLPATSCETFHQRVMESHAHTQQAIDARHDWAALREKALNFGEAEQALLVGHAFHPAPKSHEPFNQQEAERYLPDFAPHFPLRWFAVNKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLHPWQGEYLLQQEWCQELVAKGLIKDLGEAGAPWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVKRGMRLARLAQTDHWQTLQARFPTFRVMQEDGWAGLRDLHGNIMQESLFALRENLLVDQPQSQTNVLVSLTQAAPDGGDSLLVAAVKRLSDRLGITAQQAAHAWVDAYCHQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGLIYRDCQGSAFMPHAAGWLDTIGEAQAENVFTREQLLRYFPYYLLVNSTFAVTAALGAAGLDSEANLMARVRTLLAEMRDQVTHKTCLNYVLENPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLLAQEG Kraken2_NZ_JANPXN010000002.1 IMICODJL_04715 Prodigal:2.6 89571 90518 + VFG048603(gb|WP_004213921) 100.0 2.6100000000000003e-248 (iucB) N-acetyltransferase IucB VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MSKANIVHSGYGLRCEKLDKPLNLSWGLDNSAVLHWPGPLPTGWLRDALEQIFIAAPQLSAVVLPWAEWREEPQALTLFGQVKSDIIHRTAFWQLPLWLSSPANRASGEMVFDAEREIYFPLRPPRPQGEVYRRYDPRVRKTLSFRVADPVLDAERFTRWMNDPRVEYFWEQSGSLEVQTAYLERQLTGKHAFPLIGCFDDRPFSYFEIYWAAEDRIGRHYSWQPFDRGLHLLVGEQQWRGAHYVQSWLRGLTHYLLLDEPRTQRTVLEPRADNQRLFRHLEPAGYRTIKEFDFPHKRSRMVMADRHHFFTEVGL Kraken2_NZ_JANPXN010000002.1 IMICODJL_04716 Prodigal:2.6 90518 92251 + VFG048606(gb|WP_004213922) 100.0 0.0 (iucC) aerobactin siderophore biosynthesis protein IucC VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MNHKDWDFVNRQLVAKMLAELEYEQVFHAESQGDGRYCINLPGAQWRFSAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKPVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLIDLDADRLQCLLSGHPKFAFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMVWRCDSELDIQQLLAAAMDPQEFARFNQVWQDNGLDNDWLPLPVHPWQWQQKISLDFIADLAEGRMVSLGEFGDLWLAQQSLRTLTNASRQGGLDIKLPLTIYNTSCYRGIPGKYIAAGPLASRWLQQVFATDATLKQSGAVILGEPAAGYVSHEGYAALAQAPYRYQEMLGVIWRENPCRWLKPDESPILMATLMECDENNQPLIGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKKGVPQRVLLKDFQGDMRLVKDAFPEMDSLPQEVRDVTARLSADYLIHDLQTGHFVTVLRFVSPLMARLGVPERRFYQLLAAVLSDYMQEHPQMSARFALFSLFKPQIIRVVLNPVKLTWHDQDGGSRMLPNYLEDLQNPLWLATRD Kraken2_NZ_JANPXN010000002.1 IMICODJL_04717 Prodigal:2.6 92255 93532 + VFG048609(gb|WP_004213923) 100.0 0.0 (iucD) lysine 6-monooxygenase IucD VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MTNTVDFIGIGIGPFNLSIAALSHQAEGLSSRFFDGRPHFAWHPGMLVPDCHMQTMFLKDLVSAVAPTSPYSFVNYLVKRKKFYRFLTTELRTVSRDEFSDYLRWAAEGMNNLHFNHTVESIDFDERHQRFVVQTSQGESVARNICLGIGKQPHLPPCVKTATQTCFHASEMSLRRPDLGGKRVSVVGGGQSGADLFLNALRGEWGDVAEISWVSRRNNFNALDEAAFANEYFTPEYVSGFVGLNERARQKMLDEQKMTSDGITADSLLTIYRELYHRFEVLRQPRNARLLPSRSVTGLESRGQSWQLLLEHHLDNGYDTLESDVVIFATGYRPALPQILSPLMSRIAMRDECNFKVRDDFTLEWNGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARILNRVMGRDLFDLSMPPALIQWRSGT Kraken2_NZ_JANPXN010000002.1 IMICODJL_04718 Prodigal:2.6 93617 95815 + VFG048621(gb|WP_004213924) 100.0 0.0 (iutA) ferric aerobactin receptor IutA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNIDRIEVISGATSLYGGGSTGGLINIVTKKGQPETIMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTERHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAAFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIAAGKATSADAIPGGSVDYDNFLFNAGLLMHITERQQAWLNFSQGVELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTVDLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF Kraken2_NZ_JANPXN010000002.1 IMICODJL_04728 Prodigal:2.6 100703 101077 - VFG048998(gb|WP_011154608) 96.0 3.53e-87 (rmpA2) regulator of mucoid phenotype RmpA2 VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MTFRGGGEKFYPKGCDYDIYVNMQGNLKKNIEELYYAYLKKNVSRIGNHYPQLTKKEQIILQCLLSRREGIHELKSRLKIEEKTLSCHRCKITRKFGCKRFIRFMYLYNLNKEITDEKWCTSNT Kraken2_NZ_JANPXN010000002.1 IMICODJL_04729 Prodigal:2.6 101040 101342 - VFG048998(gb|WP_011154608) 100.0 4.5599999999999995e-67 (rmpA2) regulator of mucoid phenotype RmpA2 VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MEKYIYFMCNKDVTLVLTDDYYFYFGLKQLTGLPLVYITYEGSMDKPIVIKQKRNIRVLVDSRIFYSGKWDGYKMLRKTLNMISQWMWLDISGGGGEVLS Kraken2_NZ_JANPXN010000003.1 IMICODJL_04877 Prodigal:2.6 41351 42037 + VFG001445(gb|AAA92657) 99.0 1.06e-145 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MCALDRRERPLNSQSVNKYILNVQNIYRNSPVPVCVRNKNRKILYANGAFIELFSREDKPLSGESYIRLQVEIFLSSLELECQALGHGSAFCRRFNFHGEIYQIRMENVSFYNDESVVLWQINPFPDYPFFALSQSGSNTNTSDKLTIWNDLSPGTLLVFSFYMLGVGHATIARELGITDRASEDRIKPVKRKIKEFFEHFDLFRVSCIYKGKIDLLLNIIREFYSVK Kraken2_NZ_JANPXN010000004.1 IMICODJL_05071 Prodigal:2.6 85371 85931 - VFG042890(gb|WP_000334696) 64.3 3.1199999999999996e-69 (STY_RS21730) lytic transglycosylase domain-containing protein VF0966 Type IV pili VFC0001 Adherence MSGGTVPLRLISLILLFSLIPPARASYVAPKQIWTNKWDNCFAAAGARYQIEPLLLKAISAGESSLRPGAININKDKKTGKASSTDYGLMQINSTHIPKLINMGVIKKSEDLITKPCLNIHIGSWILARHFQICGVSWNCLGSYNAGFRKDRHETREQYANKIWRIYRDMKGICLPGQGGRQCRQS Kraken2_NZ_JANPXO010000002.1 IMICODJL_05181 Prodigal:2.6 76224 77246 + VFG013197(gb|WP_011608705) 66.5 1.41e-154 (hemB) porphobilinogen synthase VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MSIIIPGSFPARRLRRSRTHSFSRRLVAENQLTVNDLILPVFIIEGQNLRQEVPSMPGVFRLSVDMLLHDAAQFVQAGIPAIALFPCIESSAKSLMADASWDPSGLVPRTVRALKKAFPELGVITDVALDAYTSHGQDGIIDEHGYVLNEPTKEILTRQALTHAEAGADIVAPSDMMDGRIGHIRQAFETNGLLTIQIMAYSAKYASNYYGPFREATQSAMALGKRDKKNYQMDPANAMEALHEIAQDLQEGADMVMVKPGMPYLDIIREARKTFAVPVFAYQVSGEYAMHMAAFRHGWLDEEQTVLESLICFKRAGADGILTYFASSVAQWLNQHQREY Kraken2_NZ_JANPXO010000002.1 IMICODJL_05199 Prodigal:2.6 86847 88166 + VFG048547(gb|WP_004213617) 99.8 0.0 (iroN) salmochelin receptor IroN VF0563 Sal Salmochelin VFC0272 Nutritional/Metabolic factor Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection Inducing dissemination through chelation of host cellular iron, leading to inactivation of iron-dependent prolyl hydroxylases and the master transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) stabilization in lung epithelial cells. HIF-1alpha controls vascular permeability and inflammatory gene expression MFAPSLAKSRKETNRLYRQNYGIAHNGIWDWGQSRFGVYYEKTNNNRMNEGLSGGSEGRILADEKFTTNRLSSWRTSGEINIPLNEPVDQTLTVGVEWSRDKLDAPSSTSLTVNDSDIGGISGSAADRSSKNHSQISALYIDDNIEPVPGTNIISGLRFDYLNESGGNFSPSLNLSQELGDYFKVKAGIARTFKAPNLYQSSKGYLLYSKGNGCPKDITSGGCYLKGNKDLDPEISINKEIGLEFAWEDYYASVTYFRNDYQNKIVAGDNAIGQTASGAYILQWQNGGKALVDGIEASMAFPLVKDRLNWNTNATWMITSEQKDTGNPLSIIPKYTINNSLDWTITQAFSASVNWTLYGRQKPRTHAESRSEDTRGMSGKVLGAYSLVGTNFNYDINKNLRLNIGVSNILDKQIYRTSEGASTYNEPGRAYYVGAVVSF Kraken2_NZ_JANPXO010000002.1 IMICODJL_05203 Prodigal:2.6 90499 91086 - VFG048996(gb|WP_004213609) 99.5 7.77e-146 (rmpA) regulator of mucoid phenotype RmpA VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MLTDDYFFYYGLKQLTGLPLFHITYEGVVNKSIAIKHKRNIRVLVDSRIFYSGKWGGYKMLRGSLNMISQWMWLDVSGGGRFYPKGCDYDIYVNMQGNVKNNIEKLYFAFLKKNVSRIVNHYPRLTKKEQAVLQCLLKNGGINEIKSQLKIEEKTLSCYQSKITRKFGCKRYIRFMYLYSLNKEMVDERWLMPSI Kraken2_NZ_JANPXO010000002.1 IMICODJL_05226 Prodigal:2.6 109470 111251 + VFG048600(gb|WP_004213920) 100.0 0.0 (iucA) aerobactin Synthetase IucA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MGIFIDKILIIMTSEICLTMTLPTKTSTLDVAAQCFLNSLVRETKDWRLTEYQPTQLIIPLGEQQALHFRVAYFSPTQHHRFEFPARLVTASGSHPVDFATLSRLIVDKLQHQLLLPATSCETFHQRVMESHAHTQQAIDARHDWAALREKALNFGEAEQALLVGHAFHPAPKSHEPFNQQEAERYLPDFAPHFPLRWFAVNKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLHPWQGEYLLQQEWCQELVAKGLIKDLGEAGAPWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVKRGMRLARLAQTDDWQTLQARFPTFRVMQEDGWAGLRDLHGNIMQESLFALRENLLVDQPQSQTNVLVSLTQAAPDGGDSLLVAAVKRLSDRLGITAQQAAHAWVDAYCHQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGLIYRDCQGSAFMPHAAGWLDTIGEAQAENVFTREQLLRYFPYYLLVNSTFAVTAALGAAGLDSEANLMARVRTLLAEMRDQVTHKTCLNYVLENPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLLAQEG Kraken2_NZ_JANPXO010000002.1 IMICODJL_05227 Prodigal:2.6 111252 112199 + VFG048603(gb|WP_004213921) 100.0 2.6100000000000003e-248 (iucB) N-acetyltransferase IucB VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MSKANIVHSGYGLRCEKLDKPLNLSWGLDNSAVLHWPGPLPTGWLRDALEQIFIAAPQLSAVVLPWAEWREEPQALTLFGQVKSDIIHRTAFWQLPLWLSSPANRASGEMVFDAEREIYFPLRPPRPQGEVYRRYDPRVRKTLSFRVADPVLDAERFTRWMNDPRVEYFWEQSGSLEVQTAYLERQLTGKHAFPLIGCFDDRPFSYFEIYWAAEDRIGRHYSWQPFDRGLHLLVGEQQWRGAHYVQSWLRGLTHYLLLDEPRTQRTVLEPRADNQRLFRHLEPAGYRTIKEFDFPHKRSRMVMADRHHFFTEVGL Kraken2_NZ_JANPXO010000002.1 IMICODJL_05228 Prodigal:2.6 112199 113932 + VFG048606(gb|WP_004213922) 100.0 0.0 (iucC) aerobactin siderophore biosynthesis protein IucC VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MNHKDWDFVNRQLVAKMLAELEYEQVFHAESQGDGRYCINLPGAQWRFSAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKPVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLIDLDADRLQCLLSGHPKFAFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMVWRCDSELDIQQLLAAAMDPQEFARFNQVWQDNGLDNDWLPLPVHPWQWQQKISLDFIADLAEGRMVSLGEFGDLWLAQQSLRTLTNASRQGGLDIKLPLTIYNTSCYRGIPGKYIAAGPLASRWLQQVFATDATLKQSGAVILGEPAAGYVSHEGYAALAQAPYRYQEMLGVIWRENPCRWLKPDESPILMATLMECDENNQPLIGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKKGVPQRVLLKDFQGDMRLVKDAFPEMDSLPQEVRDVTARLSADYLIHDLQTGHFVTVLRFVSPLMARLGVPERRFYQLLAAVLSDYMQEHPQMSARFALFSLFKPQIIRVVLNPVKLTWHDQDGGSRMLPNYLEDLQNPLWLATRD Kraken2_NZ_JANPXO010000002.1 IMICODJL_05229 Prodigal:2.6 113936 115213 + VFG048609(gb|WP_004213923) 100.0 0.0 (iucD) lysine 6-monooxygenase IucD VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MTNTVDFIGIGIGPFNLSIAALSHQAEGLSSRFFDGRPHFAWHPGMLVPDCHMQTMFLKDLVSAVAPTSPYSFVNYLVKRKKFYRFLTTELRTVSRDEFSDYLRWAAEGMNNLHFNHTVESIDFDERHQRFVVQTSQGESVARNICLGIGKQPHLPPCVKTATQTCFHASEMSLRRPDLGGKRVSVVGGGQSGADLFLNALRGEWGDVAEISWVSRRNNFNALDEAAFANEYFTPEYVSGFVGLNERARQKMLDEQKMTSDGITADSLLTIYRELYHRFEVLRQPRNARLLPSRSVTGLESRGQSWQLLLEHHLDNGYDTLESDVVIFATGYRPALPQILSPLMSRIAMRDECNFKVRDDFTLEWNGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARILNRVMGRDLFDLSMPPALIQWRSGT Kraken2_NZ_JANPXO010000002.1 IMICODJL_05230 Prodigal:2.6 115298 117496 + VFG048621(gb|WP_004213924) 100.0 0.0 (iutA) ferric aerobactin receptor IutA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNIDRIEVISGATSLYGGGSTGGLINIVTKKGQPETIMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTERHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAAFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIAAGKATSADAIPGGSVDYDNFLFNAGLLMHITERQQAWLNFSQGVELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTVDLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF Kraken2_NZ_JANPXO010000002.1 IMICODJL_05242 Prodigal:2.6 123498 123797 - VFG048998(gb|WP_011154608) 100.0 5.3499999999999995e-68 (rmpA2) regulator of mucoid phenotype RmpA2 VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MEKYIYFMCNKDVTLVLTDDYYFYFGLKQLTGLPLVYITYEGSMDKPIVIKQKRNIRVLVDSRIFYSGKWDGYKMLRKTLNMISQWMWLDISGGGEVLS Kraken2_NZ_JANPXO010000003.1 IMICODJL_05421 Prodigal:2.6 74020 75405 - VFG034652(gb|WP_000074204) 72.3 7.28e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSSVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_CP083716.1 IMICODJL_05934 Prodigal:2.6 202325 204421 - VFG000080(gb|NP_464522) 62.9 1.59e-297 (clpE) ATP-dependent protease VF0073 ClpE VFC0282 Stress survival Belongs to HSP-100/Clp family An ATPase required for prolonged survival at 42 degree; acts synergistically with ClpC in cell division MRCQHCQKNEATIRLNMQVNSIQKQFVLCETCYTELTRKPSMSMGPQSFGFPFEQGFAPNQNKQQAGPEKGLLDELAQNVTNGAKAGLIDPVIGRDNEVARVIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVANTGIRGQFEERMKQLMNELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARGELQVIGATTLKEYRQIEKDAALERRFQPVMVHEPTIEQAISILEGIKDKYEKYHGVTFSNEAINACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLELDTVNEEDAAERLKAIDAEKTKALHEENYELAAKLRDEEAALEKQLAHETPASSPEIGAEHIQAIIEQKTGIPVGKLQADEQVKMKELEEHLHQRVIGQEKAVKKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGVGKTELSKTLADELFGTKDSIIRLDMSEYMEKHAVSKIIGSPPGYVGHDEAGQLTEKVRRNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVLIMTSNAGTGEKQVKVGFQSEESVLEEQTLIDSLSAFFKPEFLNRFDSIIEFQSLKKEHLVKIVSLLLTELEDTLKERGISLSVTDDAKEKIAEIGYHPAFGARPLRRTIQELIEDEMTDLLLDDNEIKAFHVVMEEDGIKVRAQ Kraken2_NZ_CP083716.1 IMICODJL_06168 Prodigal:2.6 478040 478273 + VFG011430(gb|WP_002963616) 63.0 1.3400000000000002e-21 (acpXL) acyl carrier protein VF0367 LPS Lipopolysaccharide VFC0258 Immune modulation Brucella possesses a non-classical LPS as compared with the so-called classical LPS from enterobacteria such as Escherichia coli. B. abortus lipid A possesses a diaminoglucose backbone (rather than glucosamine), and acyl groups are longer (C28 rather than C12 and C16) and are only linked to the core by amide bounds (rather than ester and amide bonds).; In contrast to enterobacterial LPSs, Brucella LPS is several-hundred-times less active and toxic than E. coli LPS.; this is an evolutionary adaptation to an intracellular lifestyle, low endotoxic activity is shared by other intracellular pathogens such as Bartonella and Legionella. Plays a role in entry and early survival inside macrophages; Resistance to innate-immunity anti-bacterial responses; a modulator of the immune response The entry and early survival stages of smooth Brucella are lipid-raft-dependent. The entry-gateway seems to include Brucella surface-exposed HSP60-PrPc (cellular prion protein) interaction but also a SR-A (class A scavenger)-lipid-A interaction and is also dependent on the LPS O-chain. And the LPS O-chain ensures the Brucella containing vacuole (BCV) aviodance of fusion with lysosomes transiently; The chemical structure of Brucella LPS permits the bacteria to become highly resistant to anti-bacterial effectors of the innate immune system. Long O-chains at the bacterial surface should provoke a steric hindrance leading to the formation of a protecting barrier. The presence of long O-chains at the surface of Brucella prevents the deposition of complement at the bacterial surface. The O-chains also could prevent a specific recognition of the Pathogen-associated molecular patterns (PAMPs) and as a consequence impair expression of any cytokines or iNOS, both of which are known to be involved in the clearance of intracellular Brucella. The low number of anionic groups in the core lipid A, especially charged phosphate groups could both remove anionic targets and facilitate a tighter aggregation of LPS molecules via their hydrophobic fatty acids, leading to less binding and penetration of antibacterial cationic peptides.;The Brucella LPS forms stable large clusters with MHC-II named macrodomians in the cell surface, interfering with MHC-II presentation of peptides to specific CD4+ T cells. MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELVMELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ Kraken2_NZ_CP083716.1 IMICODJL_06210 Prodigal:2.6 516598 516960 + VFG043408(gb|WP_000940577) 66.1 1.6999999999999998e-53 (BCE_RS08700) response regulator VF0670 Peritrichous flagella VFC0204 Motility MAHRILIVDDAAFMRMMIKDILVKNGFDVVAEASDGAQAVEKFKEHSPDLVTMDITMPEMDGITALKEIKQIDPQAKIIMCSAMGQQSMVIDAIQAGAKDFIVKPFQADRVLEAINKTLS Kraken2_NZ_CP083716.1 IMICODJL_06230 Prodigal:2.6 533914 534696 + VFG045688(gb|WP_002294134) 61.4 6.73e-106 (cpsA/uppS) undecaprenyl diphosphate synthase VF0361 Capsule VFC0258 Immune modulation The biosynthesis of capsular polysaccharides by E. faecalis is encoded by the csp operon, which includes 11 open reading frames (cpsA to cpsK). However, only 7 open reading frames in the cps operon are essential for capsule production (cpsC, cpsD, cpsE, cpsG, cpsI, cpsJ, and cpsK); Previous genetic evidence demonstrated that E. faecalis isolates can be classified in 1 of 3 capsule operon polymorphisms. CPS 1 presents only cpsA and cpsB. CPS 2 presents all 11 genes in the cps operon. CPS 5 presents all genes except for cpsF. Furthermore, CPS 2 and 5 express the capsular polysaccharide, whereas CPS 1 does not. Contributes to host immune evasion Masks bound C3 from detection on the surface of E. faecalis; masks lipoteichoic acid from detection MLNILKNWKNQQNAASNLERYTKEDILKGEIPAHIAIIMDGNGRWAKKRSLPRIAGHHEGMKVVKRVTKLASQLGVKVLTLYAFSTENWKRPKMEVDFLMKLPEEFLNTYLPELIEENVQVKIIGDESALPSHTYRAIEKAVKDTEQNDGMILNFALNYGGRTEIVNAAKALAEQVKSGTLNIEDIDEALFSGHLMTESIQDPELLIRTSGEIRLSNFMLWQVAYSEFVFTDVLWPDFKEDHFLQAVGEFQQRGRRFGGI Kraken2_NZ_CP083889.1 IMICODJL_06989 Prodigal:2.6 622 1530 - VFG012590(gb|WP_000968139) 100.0 2.69e-178 (sitD) iron/manganese ABC transporter permease subunit SitD VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MGFWQIVGVRIKRWRIAHDGIITGATAVHLYESRTLISLVVSIPCALLSVFLVLKSWALMGDAMSHAVFPGIVLAWILGLPLATGAFVAGVFCAVATGYLKDNSRIKQDTVMGIVFSGMFAAGLILYIAVKPDVHLDHILFGDMLGITIGDIIQTVIIAGLVTLVISVKWRDFLLFSFDYQQAQASGLHTRWLHYGLLCMVSLTIVATLKAVGIILSISLLIAPGAIAVLLTQRFHIALLLATGISILVSMTGVWLSFFIDSAPAPTIVVLFAVMFIMTFTVTSINARTKENAEPRDLLSSD Kraken2_NZ_CP083889.1 IMICODJL_06990 Prodigal:2.6 1475 2332 - VFG012585(gb|WP_001101723) 100.0 1.48e-198 (sitC) iron/manganese ABC transporter permease subunit SitC VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MNVLLEPFSYEYMLNAMWVSAMVGGLCAFLSCYLMLKGWSLIGDALSHSIVPGVAGAYMLGLPFSLGAFFSGGLAAGSMLFLNQLTRLKEDAIIGLIFSSFFGLGLFMVSLNPTSVNIQTIVLGNILAIDPADILQLTIIGILSIIVLFFKWKDLMVTFFDENHARAIGLHPGRLKILFFTLLSVSTVAALQTVGAFLVICLVVTPGATAWLLTDRFPRLLMIAVTIGSVTSFLGAWVSYFLDGATGGIIVVAQTLLFLLAFVFAPTHGLLANRRRAHKALEDRS Kraken2_NZ_CP083889.1 IMICODJL_06991 Prodigal:2.6 2329 3153 - VFG034214(gb|WP_000983710) 100.0 3.3500000000000003e-192 (sitB) iron/manganese ABC transporter ATP-binding protein SitB VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MQSAGIVVNDVTVTWRNGHTALRDASFTVPGGSIAALVGVNGSGKSTLFKAIMGFVRLTSGKISVLGIPTRQALQKNLVAYVPQSEEVDWSFPVLVEDVVMMGRYGHMGMLRIAKKRDRQIVTDALERVDMVDFRHRQIGELSGGQKKRVFLARAIAQQGDVILLDEPFTGVDVKTEAKIISLLRELRAEGKTMLVSTHNLGSVTTFCDYTVMVKGTVLASGPTDTTFTAENLELAFSGVLRHVTLNGSEESIITDDERPFVAHRPSAVQREER Kraken2_NZ_CP083889.1 IMICODJL_06992 Prodigal:2.6 3156 4070 - VFG012575(gb|WP_000949004) 100.0 4.37e-221 (sitA) iron/manganese ABC transporter substrate-binding protein SitA VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MLSIKKVTMLLGCLVLTCSIAFQASAAEKFKVITTFTIIADMAKNVAGDAAEVSSITKPGAEIHEYQPTPGDIKRAQGAQLILANGMNLELWFQRFYQHLNGVPEVIVSSGVTPVGITEGPYEGKPNPHAWMSPDNALIYVDNIRDAFIKYDPANAQTYQRNADTYKAKITQTLAPLRKQIAELPENQRWMVTSEGAFSYLARDLGLKELYLWPINADQQGTPQQVRKVVDIVKKNHIPAVFSESTISDKPARQVARETGAHYGGVLYVDSLSTENGPVPTYIDLLKVTTSTLVQGIKAGKREK Kraken2_NZ_CP083889.1 IMICODJL_07003 Prodigal:2.6 12527 13198 - VFG012928(gb|WP_005005342) 61.4 1.42e-93 (icsP/sopA) outer membrane protease of the OmpP family, involved in cleavage of surface exposed IcsA VF0122 IcsP (SopA) VFC0251 Exoenzyme Involved in the cleavage of IcsA, may contribute to the polar distribution of IcsA on the lateral side of the bacterial surface IcsP is a 36.9 kDa OM protease that cleaves the autotransporter by releasing the ~95 kDa IcsA passenger domain MYLKILATALSAPVAFAALASDTGLSFTPEKISTEIDFGTLSGKAKERVYLPEEKGRKASQLDWKYSNAPIVKGAFNWDLLPRVSVGASGWTTLAGRGGNMVDRDWLDTSNPGTWTDESKHPNTRLNFANEFDLNIKGWLLNQPDYQLGLMAGYQENRYSFTAKGGSYIYSSEGGFRDETGSFPDGERAIGYKQHFKMPYIGLTGNYRYDSFEFGGVSNIADG Kraken2_NZ_CP083889.1 IMICODJL_07024 Prodigal:2.6 32996 34111 + VFG012515(gb|WP_001318220) 100.0 1.3600000000000001e-276 (iroB) glucosyltransferase IroB VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MRILFVGPPLYGLLYPVLSLAQAFRVNGHEVLIASGGQFAQKAAEAGLVVFDAAPGLDSEAGYRHHEAQRKKSNIGTQMGNFSFFSEEMADHLVEFAGHWRPDLIIYPPLGVIGPLIAAKYDIPVVMQTVGFGHTPWHIKGVTRSLTDAYRRHNVGATPRDMAWIDVTPPSMSILENDGEPIIPMQYVPYNGGAVWEPWWERRPERKRLLVSLGTVKPMVDGLDLIAWVMDSASEVDAEIILHISANARSDLRSLPSNVRLVDWIPMGVFLNGADGFIHHGGAGNTLTALHAGIPQIVFGQGADRPVNARVVAERGCGIIPGDVGLSSNMINAFLNNRSLRKASEEVAAEMAAQPCPGEVAKSLITMVQKG Kraken2_NZ_CP083889.1 IMICODJL_07025 Prodigal:2.6 34251 37910 + VFG012511(gb|WP_001442133) 100.0 0.0 (iroC) ATP binding cassette transporter VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MPANHTPTPAQSWIVRLARVCWERKKLSVIVVVASVSTILLAALTPLLTRQAVNDALAGNPARLPWLACGLLLIAFFDFIGNYVRRGYAGMLSLWVQHTLRGRVFDSIQKLDGAGQDALRTGQVISRTNSDLQQVHTLLQMCPVPLAVFTYYIAGIAVMLWMSPAMTLIVVCVLVCLAITALRARRRVFAQTGLASDQLANLTEHIREVLAQISVVKSCVAEMRETHWLDRQSRQIVRVRIGAVISQAMPGATMLALPVLGQIVLLCYGGWSVMHGRIDLGTFVAFASFLAMLTGPTRVLASFLVIAQRTQASVERVFALIDTRSQMEDGTESINSQVVGLELENMSFDYHHGDRHILSNISFSLRAGETVAVVGASGSGKSTLLMLLARFYDPCSGKIWLNTSEGRQNLRDIRLEALRRRVGIVFEDAFLFAGTVAENIAYGHPQATADDIRRAAAAAGASDFINALPKGFDSLLTERGTNLSGGQRQRIALARALITAPDVLILDDTTSAVDAVTEAEINTALGRYADEGHMLLVIARRRSTLQLASRVVVLDKGRMVDTGTPAELEARCPAFRALMTGDSDFLATSHNSHNELWPAEPATQDDVTDTGDKGFVARMTRVPENAVQQALAGKGRKVTSLLKPVAWMFVIAALLIALDSAAGVGVLILLQHGIDSGVAAGDMSIIGLCALLALCLVIVGWCSYSLQTVFAARAAESVQHSVRLRSFGHMLRLGLPWHEKHADSRLTRMTVDVDSLARFLQNGLAGAATSLVTMFAIAATMFWLDPFLALTALSAVPVAALATMIYRRLSTPAYAQARLEIGKVNSTLQEKVSGLRVVQSHGQQELEGARLRALSERFRATRVRAQKYLAVYFPFLTFCTEASYAAVLLVGASQVAAGEMTAGVLAAFFLLLGQFYGPVQQLSGIVDAWQQATASGKHIDELLATEGTENLGSSSVLPVTGALHLDEVTFSYPDSHEPALNKLTLTIPEGMVVAVVGRSGAGKSTLIKLIAGLYFPTHGNIRIGVQMLDDASLTEYRRQIGLVDQDVALFSSDIAENIRYSRPSATNEDVEIASQRAGLYEMVCNLPQGFRTPVNNGGADLPAGQRQLIALARAQLANAHILLLDEATSCLDRTSEERLMSSLTDVVHAGKHSALIVAHRLTTAQRCDLIAVIDKGLLAEYGTHEQLLSAGGLYTRLWHDSVSSTALHRQHNMKEETPG Kraken2_NZ_CP083889.1 IMICODJL_07026 Prodigal:2.6 38014 39243 + VFG012508(gb|WP_000933675) 100.0 2.71e-309 (iroD) esterase VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MLNMQQHPSAIASLRNQLAAGHIANLTDFWREAESLNVPLVTPVEGAEDEREVTFLWRARHPLQGVYLRLNRVTDKEHVEKGMMSALPETDIWTLTLRLPASYCGSYSLLEIPPGTTAETIALSGGRFATLAGKADPLNKMPEINVRGNAKESVLTLDKAPALSEWNGGFHTGQLLTSMRIIAGKSRQVRLYIPDVDISQPLGLVVLPDGETWFDHLGVCAAIDAAINNGRIVPVAVLGIDNINEHERTEILGGRSKLIKDIAGHLLPMIRAEQPQRQWADRSRTVLAGQSLGGISALMGARYAPETFGLVLSHSPSMWWTPERTSRPGLFSETDTSWVSEHLLSAPPQGVRISLCVGSLEGSTVPHVQQLHQRLITAGVESHCAIYTGGHDYAWWRGALIDGIGLLQG Kraken2_NZ_CP083889.1 IMICODJL_07027 Prodigal:2.6 39328 40284 + VFG012503(gb|WP_000271277) 100.0 3.4099999999999996e-241 (iroE) esterase VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MYAREYRSTRPHKAIFFHLSCLTLICSAQVYAKPDMRPLGPNIADKGSVFYHFSVTSFDSVDGTRHYRVWTAVPNTTAPASGYPILYMLDGNAVMDRLDDELLKQLSEKTPPVIVAVGYQTNLPFDLNSRAYDYTPAAESRKTDLHSGRFSRKSGGSNNFRQLLETRIAPKVEQGLNIDRQRRGLWGHSYGGLFVLDSWLSSSYFRSYYSASPSLGRGYDALLSRVTAVEPLQFCAKHLAIMEGSATQGDNRETHAVGVLSKIHTTLTILKDKGVNAVFWDFPNLGHGPMFNASFRQALLDISGENANYTAGCHELSH Kraken2_NZ_CP083889.1 IMICODJL_07028 Prodigal:2.6 40329 42506 - VFG012499(gb|WP_001222186) 100.0 0.0 (iroN) salmochelin receptor IroN VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MRINKILWSLTVLLVGLNSQVSVAKSSDDDNDETLVVEATAEQVLKQQPGVSVITSEDIKKTPPVNDLSDIIRKMPGVNLTGNSASGTRGNNRQIDIRGMGPENTLILIDGVPVTSRNSVRYSWRGERDTRGDTNWVPPEQVERIEVIRGPAAARYGSGAAGGVVNIITKRPTNDWHGSLSLYTNQPESSDEGATRRANFSLSGPLAGNALTTRLYGNLNKTDADSWDINSPVGTKNAAGHEGVRNKDINGVVSWKLNPQQILDFEAGYSRQGNIYAGDTQNSSSSAVTESLAKSGKETNRLYRQNYGITHNGIWDWGQSRFGVYYEKTNNTRMNEGLSGGGEGRILAGEKFTTNRLSSWRTSGELNIPLNVMVDQTLTVGAEWNRDKLDDPSSTSLTVNDSDISGISGSAADRSSKNHSQISALYIEDNIEPVPGTNIIPGLRFDYLSDSGGNFSPSLNLSQELGDYFKVKAGVARTFKAPNLYQSSEGYLLYSKGNGCPKDITSGGCYLIGNKDLDPEISVNKEIGLEFTWEDYHASVTYFRNDYQNKIVAGDNVIGQTASGAYILKWQNGGKALVDGIEASMSFPLVKDRLNWNTNATWMITSEQKDTGNPLSVIPKYTINNSLNWTITQAFSASVNWTLYGRQKPRTHAETRSEDTGGLSGKELGAYSLVGTNFNYDINKNLRLNVGVSNILNKQIFRSSEGANTYNEPGRAYYAGVTASF Kraken2_NZ_CP083889.1 IMICODJL_07044 Prodigal:2.6 49411 53544 - VFG042364(gb|CAA11507) 99.9 0.0 (hbp) haemoglobin protease VF1167 Hbp (hemoglobin-binding protease) VFC0086 Effector delivery system MNRIYSLRYSAVARGFIAVSEFARKCVHKSVRRLCFPVLLLIPVLFSAGSLAGTVNNELGYQLFRDFAENKGMFRPGATNIAIYNKQGEFVGTLDKAAMPDFSAVDSEIGVATLINPQYIASVKHNGGYTNVSFGDGENRYNIVDRNNAPSLDFHAPRLDKLVTEVAPTAVTAQGAVAGAYLDKERYPVFYRLGSGTQYIKDSNGQLTKMGGAYSWLTGGTVGSLSSYQNGEMISTSSGLVFDYKLNGAMPIYGEAGDSGSPLFAFDTVQNKWVLVGVLTAGNGAGGRGNNWAVIPLDFIGQKFNEDNDAPVTFRTSEGGALEWSFNSSTGAGALTQGTTTYAMHGQQGNDLNAGKNLIFQGQNGQINLKDSVSQGAGSLTFRDNYTVTTSNGSTWTGAGIVVDNGVSVNWQVNGVKGDNLHKIGEGTLTVQGTGINEGGLKVGDGKVVLNQQADNKGQVQAFSSVNIASGRPTVVLTDERQVNPDTVSWGYRGGTLDVNGNSLTFHQLKAADYGAVLANNVDKRATITLDYALRADKVALNGWSESGKGTAGNLYKYNNPYTNTTDYFILKQSTYGYFPTDQSSNATWEFVGHSQGDAQKLVADRFNTAGYLFHGQLKGNLNVDNRLPEGVTSALVMDGAADISGTFTQENGRLTLQGHPVIHAYNTQSVADKLAASGDHSVLTQPTSFSQEDWENRSFTFDRLSLKNTDFGLGRNATLNTTIQADNSSVTLGDSRVFIDKNDGQGTAFTLEEGTSVATKDADKSVFNGTVNLDNQSVLNINDIFNGGIQANNSTVNISSDSAVLGNSTLTSTALNLNKGANALASQSFVSDGPVNISDATLSLNSRPDEVSHTLLPVYDYAGSWNLKGDDARLNVGPYSMLSGNINVQDKGTVTLGGEGELSPDLTLQNQMLYSLFNGYRNIWSGSLNAPDATVSMTDTQWSMNGNSTAGNMKLNRTIVGFNGGTSPFTTLTTDNLDAVQSAFVMRTDLNKADKLVINKSATGHDNSIWVNFLKKPSNKDTLDIPLVSAPEATADNLFRASTRVVGFSDVTPILSVRKEDGKKEWVLDGYQVARNDGQGKAAATFMHISYNNFITEVNNLNKRMGDLRDINGEAGTWVRLLNGSGSADGGFTDHYTLLQMGADRKHELGSMDLFTGVMATYTDTDASADLYSGKTKSWGGGFYASGLFRSGAYFDVIAKYIHNENKYDLNFAGAGKQNFRSHSLYAGAEVGYRYHLTDTTFVEPQAELVWGRLQGQTFNWNDSGMDVSMRRNSVNPLVGRTGVVSGKTFSGKDWSLTARAGLHYEFDLTDSADVHLKDAAGEHQINGRKDSRMLYGVGLNARFGDNTRLGLEVERSAFGKYNTDDAINANIRYSF Kraken2_NZ_CP083889.1 IMICODJL_07202 Prodigal:2.6 188257 190455 - VFG033944(gb|WP_000973519) 99.9 0.0 (iutA) ferric aerobactin receptor precusor IutA VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNIDHIEVISGATSLYGGGSTGGLINIVTKKGQPETMMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTERHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAVFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIAAGKATSADAIPGGSVDYDNFLFNAGLLMHITERQQAWLNFSQGVELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTVDLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF Kraken2_NZ_CP083889.1 IMICODJL_07203 Prodigal:2.6 190540 191817 - VFG033958(gb|WP_000750130) 100.0 0.0 (iucD) L-lysine 6-monooxygenase IucD VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MKKSVDFIGVGTGPFNLSIAALSHQIEELDCLFFDEHPHFSWHPGMLVPDCHMQTVFLKDLVSAVAPTNPYSFVNYLVKHKKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVENIDFDKKRRLFLVQTSQGEYFARNICLGTGKQPYLPPCVKHMTQSCFHASEMNLRRPDLSGKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISGFSGLEEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLESSGPGWKLLMEHHLDQGRESLESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDDFTLEWSGPKENNIFVVNASMQTHGIAEPQLSLMAWRSARILNRVMGRDLFDLSMPPALIQWRSGT Kraken2_NZ_CP083889.1 IMICODJL_07204 Prodigal:2.6 191814 193556 - VFG012522(gb|WP_001015721) 100.0 0.0 (iucC) aerobactin siderophore biosynthesis protein IucC VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MNHKDWDLVNRRLVAKMLSELEYEQVFHAESQGDDRYCINLPGAQWRFIAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKQVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLINLNADRLQCLLSGHPKFVFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMIWRCDNEMDIHQLLTAAMDPQEFARFSQVWQENGLDHNWLPLPVHPWQWQQKIATDFIADFAEGRMVSLGEFGDQWLAQQSLRTLTNASRRGGLDIKLPLTIYNTSCYRGIPGRYIAAGPLASRWLQQVFATDATLVQSGAVILGEPAAGYVSHEGYAALARAPYRYQEMLGVIWRENPCRWLKPDESPVLMATLMECDENNQPLAGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKEGVPQRVLLKDFQGDMRLVKEEFPEMDSLPQEVRDVTSRLSADYLIHDLQTGHFVTVLRFISPLMVRLGVPERRFYQLLAAVLSDYMKKHPQMSERFALFSLFRPQIIRVVLNPVKLTWPDLDGGSRMLPNYLEDLQNPLWLVTQEYES Kraken2_NZ_CP083889.1 IMICODJL_07205 Prodigal:2.6 193556 194503 - VFG033993(gb|WP_000011910) 99.7 5.26e-248 (iucB) aerobactin siderophore biosynthesis protein IucB VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MSGANIVHSGYGLRCEKLDKPLNLGWGLDNSAVLHWPGELPTGWLCDALDQIFIAAPQLSAVVLPWSEWCEEPQALTLFGQVQSDIIHRSAFWQLPLWLSSPANRASGEMVFDAEREIYFPQRPPRPQGEVYRRYDPRIRRMLSFRIADPVSDAERFTRWMNDPRVEYFWEQSGSLEVQIAYLERQLTSKHAFPLIGCFDDRPFSYFEIYWAAEDRIGRHYSWQPFDRGLHLLVGEQQWRGAHYVQSWLRGVTHYLLLNEPRTQRTVLEPRTDNQRLFRHLEPAGYRTIKEFDFPHKRSRMVMADRHHFFTEVGL Kraken2_NZ_CP083889.1 IMICODJL_07206 Prodigal:2.6 194504 196228 - VFG012526(gb|WP_000602863) 100.0 0.0 (iucA) aerobactin siderophore biosynthesis protein IucD VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MILPSEKSATDVAAQCFLNALIRETKDWQLAEYPPDELIIPLDEQKSLHFRVAYFSPTQHHRFAFPAHLVTASGSYPVDFTTLSRLIIDKLRHQLFLPVPLCETFHQRVLESYAHTQQTIDARHDWAILREKALNFGEAEQALLTGHAFHPAPKSHEPFNRQEAERYLPDMAPHFPLRWFSVDKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLHPWQGEYLLQQVWCQALFAKGLIRDLGEAGTSWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVERGMRLARLAQTDGWQMLQARFPTFRVMQEDGWAGLRDLNGNIMQESLFSLRENLLLEQPQSQTNVLVSLTQAAPDGGDSLLVSAVKRLSDRLGITVQQAAHAWVDAYCQQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGFIYRDCQGSAFMPHATEWLDTIDEAQAENIFTREQLLRYFPYYLLVNSTFAVTAALGAAGLDSEANLMARVRTLLAEVRDQVTHKTCLNYVLESPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLQAQEV Kraken2_NZ_CP083889.1 IMICODJL_07211 Prodigal:2.6 199560 200417 - VFG012590(gb|WP_000968139) 100.0 1.78e-190 (sitD) iron/manganese ABC transporter permease subunit SitD VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MMALLLEPLQFTFMSHALLISLVVSIPCALLSVFLVLKSWALMGDAMSHAVFPGIVLAWILGLPLATGAFVAGVFCAVATGYLKDNSRIKQDTVMGIVFSGMFAAGLILYIAVKPDVHLDHILFGDMLGITIGDIIQTVIIAGLVTLVISVKWRDFLLFSFDYQQAQASGLHTRWLHYGLLCMVSLTIVATLKAVGIILSISLLIAPGAIAVLLTQRFHIALLLATGISILVSMTGVWLSFFIDSAPAPTIVVLFAVMFIMTFTVTSINARTKENAEPRDLLSSD Kraken2_NZ_CP083889.1 IMICODJL_07212 Prodigal:2.6 200414 201271 - VFG012585(gb|WP_001101723) 100.0 1.48e-198 (sitC) iron/manganese ABC transporter permease subunit SitC VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MNVLLEPFSYEYMLNAMWVSAMVGGLCAFLSCYLMLKGWSLIGDALSHSIVPGVAGAYMLGLPFSLGAFFSGGLAAGSMLFLNQLTRLKEDAIIGLIFSSFFGLGLFMVSLNPTSVNIQTIVLGNILAIDPADILQLTIIGILSIIVLFFKWKDLMVTFFDENHARAIGLHPGRLKILFFTLLSVSTVAALQTVGAFLVICLVVTPGATAWLLTDRFPRLLMIAVTIGSVTSFLGAWVSYFLDGATGGIIVVAQTLLFLLAFVFAPTHGLLANRRRAHKALEDRS Kraken2_NZ_CP083889.1 IMICODJL_07213 Prodigal:2.6 201240 202091 - VFG034214(gb|WP_000983710) 100.0 1.69e-132 (sitB) iron/manganese ABC transporter ATP-binding protein SitB VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MQSAGIVVNDVTVTWRNGHTALRDASFTVPGGSIAALVGVNGSGKSTLFKAIMGFVRLTSGKISVLGIPTRQALQKNLVAYVPQSEEVDWSFPVLVEDVVMMGRYGHMGMLRIAKKRDRQIVTDALERVDMVDFRHRQIGELSGGQKKRVFLARAIAQQGDVILLDEPFTGVDVKTEAKIISLLRELRAEGKTMLSQRTISDPSRHFAIIRSWSKAPSWQAGRQTPLLQPRTWSWLLAAYCAMSHLTARKKALLLTMNALLWHIDRQRCRGKKDERATGTLQL Kraken2_NZ_CP083889.1 IMICODJL_07214 Prodigal:2.6 202094 203008 - VFG012575(gb|WP_000949004) 100.0 4.37e-221 (sitA) iron/manganese ABC transporter substrate-binding protein SitA VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MLSIKKVTMLLGCLVLTCSIAFQASAAEKFKVITTFTIIADMAKNVAGDAAEVSSITKPGAEIHEYQPTPGDIKRAQGAQLILANGMNLELWFQRFYQHLNGVPEVIVSSGVTPVGITEGPYEGKPNPHAWMSPDNALIYVDNIRDAFIKYDPANAQTYQRNADTYKAKITQTLAPLRKQIAELPENQRWMVTSEGAFSYLARDLGLKELYLWPINADQQGTPQQVRKVVDIVKKNHIPAVFSESTISDKPARQVARETGAHYGGVLYVDSLSTENGPVPTYIDLLKVTTSTLVQGIKAGKREK Kraken2_NZ_CP083890.1 IMICODJL_07299 Prodigal:2.6 55971 56603 - VFG017870(gb|WP_011988518) 77.9 3.98e-113 (YPSIP31758_RS00990) ParA family protein VF1026 Icm/dot type IVB locus VFC0086 Effector delivery system MAWIVGFISQKGGVGKSTKARALAREASACGIKTKLADLDLEQATSAEWHRRRLSAGLSPVASVEVFSTAKQAIESAGDFDLLILDGPARASKGTSEIAKVADLIVQPTGASLDDLVPAIKVFNALVKEGIPRSKLVFALSRVGTEAEELDARAYISEAGYETLSGCLFEKPAYRKAMNSGLAVTETRYKGLNERADELIQALIDKIGEE Kraken2_NZ_CP083890.1 IMICODJL_07306 Prodigal:2.6 60652 62532 - VFG043980(gb|WP_001283355) 99.7 0.0 (HS453_RS00480) colicin-like pore-forming protein VF1184 Colicin Ib VFC0235 Exotoxin MSDPVRITNPGAESLGYDSDGHEIMAVDIYVNPPRVDVFHGTPPAWSSFGNKTIWGGNEWVDDSPTRSDIEKRDKEITAYKNTLSVQQKENENKRTEAGKRLSAAIAAREKDENTLKTLRAGNADVADITRQEFRLLQAELREYGFRTEIAGYDALRLHTESRMLFADADSLRISPREARSLIEQAEKRQKDAQNADKKAADMLAEYERRKGILDTRLSELEKNGGAALAVLDAQQARLLGQQTRNDRAISEARNKLSSVTESLKTARNALTRAEQQLTQQKNTPDGKTIVSPEKFPGRSSTNHSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLTHSGLDYKRNILNDRNPVVTEDVEGDKKIYNAEVAEWDKLRQRLLDARNKITSAESAVNSARNNVSARTNEQKHANDALNALLKEKENIRSQLADINQKIAEEKRKRDEINMIKDAIKLTSDFYRTIYDEFGKQASELAKELASVSQGKQIKSVDDALNAFDKFRNNLNKKYSIQDRMAISKALEAINQVHMAENFKLFSKAFGFTGKVIDRYDVAVELQKAVKTDNWRPFFVKLESLAAGRAASAVTAWTFSVMLGTPVGILGFAIIMAAVSAFVNDKFIEQVNKLIGI Kraken2_NZ_CP083890.1 IMICODJL_07356 Prodigal:2.6 109852 110412 + VFG042890(gb|WP_000334696) 64.3 3.1199999999999996e-69 (STY_RS21730) lytic transglycosylase domain-containing protein VF0966 Type IV pili VFC0001 Adherence MSGGTVPLRLISLILLFSLIPPARASYVAPKQIWTNKWDNCFAAAGARYQIEPLLLKAISAGESSLRPGAININKDKKTGKASSTDYGLMQINSTHIPKLINMGVIKKSEDLITKPCLNIHIGSWILARHFQICGVSWNCLGSYNAGFRKDRHETREQYANKIWRIYRDMKGICLPGQGGRQCRQS Kraken2_NZ_CP083884.1 IMICODJL_07585 Prodigal:2.6 110977 111891 + VFG012575(gb|WP_000949004) 100.0 4.37e-221 (sitA) iron/manganese ABC transporter substrate-binding protein SitA VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MLSIKKVTMLLGCLVLTCSIAFQASAAEKFKVITTFTIIADMAKNVAGDAAEVSSITKPGAEIHEYQPTPGDIKRAQGAQLILANGMNLELWFQRFYQHLNGVPEVIVSSGVTPVGITEGPYEGKPNPHAWMSPDNALIYVDNIRDAFIKYDPANAQTYQRNADTYKAKITQTLAPLRKQIAELPENQRWMVTSEGAFSYLARDLGLKELYLWPINADQQGTPQQVRKVVDIVKKNHIPAVFSESTISDKPARQVARETGAHYGGVLYVDSLSTENGPVPTYIDLLKVTTSTLVQGIKAGKREK Kraken2_NZ_CP083884.1 IMICODJL_07586 Prodigal:2.6 111894 112718 + VFG012580(gb|WP_000983712) 100.0 2.36e-192 (sitB) iron/manganese ABC transporter ATP-binding protein SitB VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MQSAGIVVNDVTVTWRNGHTALRDASFTVPGGSIAALVGVNGSGKSTLFKAIMGFVRLTSGKISVLGIPTRQALQKNLVAYVPQSEEVDWSFPVLVEDVVMMGRYGHMGMLRIAKKRDRQIVTDALERVDMVDFRHRQIGELSGGQKKRVFLARAIAQQGYVILLDEPFTGVDVKTEAKIISLLRELRAEGKTMLVSTHNLGSVTTFCDYTVMVKGTVLASGPTDTTFTAENLELAFSGVLRHVTLNGSEESIITDDERPFVAHRPSAVQREER Kraken2_NZ_CP083884.1 IMICODJL_07587 Prodigal:2.6 112715 113572 + VFG012585(gb|WP_001101723) 100.0 1.48e-198 (sitC) iron/manganese ABC transporter permease subunit SitC VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MNVLLEPFSYEYMLNAMWVSAMVGGLCAFLSCYLMLKGWSLIGDALSHSIVPGVAGAYMLGLPFSLGAFFSGGLAAGSMLFLNQLTRLKEDAIIGLIFSSFFGLGLFMVSLNPTSVNIQTIVLGNILAIDPADILQLTIIGILSIIVLFFKWKDLMVTFFDENHARAIGLHPGRLKILFFTLLSVSTVAALQTVGAFLVICLVVTPGATAWLLTDRFPRLLMIAVTIGSVTSFLGAWVSYFLDGATGGIIVVAQTLLFLLAFVFAPTHGLLANRRRAHKALEDRS Kraken2_NZ_CP083884.1 IMICODJL_07588 Prodigal:2.6 113569 114426 + VFG012590(gb|WP_000968139) 100.0 1.78e-190 (sitD) iron/manganese ABC transporter permease subunit SitD VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MMALLLEPLQFTFMSHALLISLVVSIPCALLSVFLVLKSWALMGDAMSHAVFPGIVLAWILGLPLATGAFVAGVFCAVATGYLKDNSRIKQDTVMGIVFSGMFAAGLILYIAVKPDVHLDHILFGDMLGITIGDIIQTVIIAGLVTLVISVKWRDFLLFSFDYQQAQASGLHTRWLHYGLLCMVSLTIVATLKAVGIILSISLLIAPGAIAVLLTQRFHIALLLATGISILVSMTGVWLSFFIDSAPAPTIVVLFAVMFIMTFTVTSINARTKENAEPRDLLSSD Kraken2_NZ_CP083884.1 IMICODJL_07593 Prodigal:2.6 117758 119482 + VFG012526(gb|WP_000602863) 100.0 0.0 (iucA) aerobactin siderophore biosynthesis protein IucD VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MILPSEKSATDVAAQCFLNALIRETKDWQLAEYPPDELIIPLDEQKSLHFRVAYFSPTQHHRFAFPAHLVTASGSYPVDFTTLSRLIIDKLRHQLFLPVPLCETFHQRVLESYAHTQQTIDARHDWAILREKALNFGEAEQALLTGHAFHPAPKSHEPFNRQEAERYLPDMAPHFPLRWFSVDKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLHPWQGEYLLQQVWCQALFAKGLIRDLGEAGTSWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVERGMRLARLAQTDGWQMLQARFPTFRVMQEDGWAGLRDLNGNIMQESLFSLRENLLLEQPQSQTNVLVSLTQAAPDGGDSLLVSAVKRLSDRLGITVQQAAHAWVDAYCQQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGFIYRDCQGSAFMPHATEWLDTIDEAQAENIFTREQLLRYFPYYLLVNSTFAVTAALGAAGLDSEANLMARVRTLLAEVRDQVTHKTCLNYVLESPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLQAQEV Kraken2_NZ_CP083884.1 IMICODJL_07594 Prodigal:2.6 119483 120430 + VFG012524(gb|WP_000011907) 100.0 1.8400000000000002e-248 (iucB) aerobactin siderophore biosynthesis protein IucB VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MSGANIVHSGYGLRCEKLDKPLNLGWGLDNSAVLHWPGELPTGWLCDALDQIFIAAPQLSAVVLPWSEWCEEPQALTLFGQVQSDIIHRSAFWQLPLWLSSPANRASGEMVFDAEREIYFPQRPPRPQGEVYRRYDPRIRRMLSFRIADPVSDAERFTRWMNDPRVEYFWEQSGSLEVQIAYLERQLTSKHAFPLIGCFDDRPFSYFEIYWAAEDRIGRHYSWQPFDRGLHLLVGEQQWRGAHYVQSWLRGVTHYLLLNEPRTQRTVLEPRIDNQRLFRHLEPAGYRTIKEFDFPHKRSRMVMADRHHFFTEVGL Kraken2_NZ_CP083884.1 IMICODJL_07595 Prodigal:2.6 120430 122172 + VFG012522(gb|WP_001015721) 100.0 0.0 (iucC) aerobactin siderophore biosynthesis protein IucC VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MNHKDWDLVNRRLVAKMLSELEYEQVFHAESQGDDRYCINLPGAQWRFIAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKQVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLINLNADRLQCLLSGHPKFVFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMIWRCDNEMDIHQLLTAAMDPQEFARFSQVWQENGLDHNWLPLPVHPWQWQQKIATDFIADFAEGRMVSLGEFGDQWLAQQSLRTLTNASRRGGLDIKLPLTIYNTSCYRGIPGRYIAAGPLASRWLQQVFATDATLVQSGAVILGEPAAGYVSHEGYAALARAPYRYQEMLGVIWRENPCRWLKPDESPVLMATLMECDENNQPLAGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKEGVPQRVLLKDFQGDMRLVKEEFPEMDSLPQEVRDVTSRLSADYLIHDLQTGHFVTVLRFISPLMVRLGVPERRFYQLLAAVLSDYMKKHPQMSERFALFSLFRPQIIRVVLNPVKLTWPDLDGGSRMLPNYLEDLQNPLWLVTQEYES Kraken2_NZ_CP083884.1 IMICODJL_07596 Prodigal:2.6 122169 123446 + VFG033958(gb|WP_000750130) 99.5 0.0 (iucD) L-lysine 6-monooxygenase IucD VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MKKSVDFIGVGTGPFNLSIAALSHQIEELDCLFFDEHPHFSWHPGMLVPDCHMQTVFLKDLVSAVAPTNPYSFVNYLVKHKKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVENIDFDKKRRLFLVQTSQGEYFARNICLGTGKQPYLPPCVKHMTQSCFHASEMNLRRPDLSGKRITVVGGGQSGADLLLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISGFSGLEEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLESSGPGWKLLMEHHLDQGRESLESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDDFTLEWSGPKENNIFVVNASMQTHGIAEPQLSLMAWRSARILNRVMGRDLFDLSMPPALIQWRSST Kraken2_NZ_CP083884.1 IMICODJL_07597 Prodigal:2.6 123531 125729 + VFG012518(gb|WP_000973517) 100.0 0.0 (iutA) ferric aerobactin receptor precusor IutA VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNIDHIEVISGATSLYGGGSTGGLINIVTKKGQPETMMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTERHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAAFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIAAGKATSADAIPGGSVDYDNFLFNAGLLMHITERQQAWLNFSQGVELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTADLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF Kraken2_NZ_CP083707.1 IMICODJL_08372 Prodigal:2.6 57614 58174 - VFG042890(gb|WP_000334696) 64.3 3.1199999999999996e-69 (STY_RS21730) lytic transglycosylase domain-containing protein VF0966 Type IV pili VFC0001 Adherence MSGGTVPLRLISLILLFSLIPPARASYVAPKQIWTNKWDNCFAAAGARYQIEPLLLKAISAGESSLRPGAININKDKKTGKASSTDYGLMQINSTHIPKLINMGVIKKSEDLITKPCLNIHIGSWILARHFQICGVSWNCLGSYNAGFRKDRHETREQYANKIWRIYRDMKGICLPGQGGRQCRQS Kraken2_NZ_CP083707.1 IMICODJL_08392 Prodigal:2.6 77324 79204 + VFG044067(gb|WP_001283335) 99.0 0.0 (ECS88_RS00560) colicin-like pore-forming protein VF1183 Colicin Ia VFC0235 Exotoxin MSDPVRITNPGAESLGYDSDGHEIMAVDIYVNPPRVDVFHGTPPAWSSFGNKTIWGGNEWVDDSPTRSDIEKRDKEITAYKNTLSAQQKENENKRTEAGKRLSAAIAAREKDENTLKTLRAGNADAADITRQEFRLLQAELREYGFRTEIAGYDALRLHTESRMLFADADSLRISPREARSLIEQAEKRQKDAQNTDKKAADMLAEYERRKGILDTRLSELEKNGGAALAVLDAQQARLLGQQTRNDRAISEARNKLSSVTESLNTARNALTRAEQQLTQQKNTPDGKTIVSPEKFPGRSSTNHSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLTHSGLDYKRNILNDRNPVVTEDVEGDKKIYNAEVAEWDKLRQRLLDARNKITSAESAVNSARNNLSARTNEQKHANDALNALLKEKENIRNQLAGINQKIAEEKRKQDELKATKDAINFTTEFLKSVSEKYGAKAEQLAREMAGQAKGKKIRNVEEALKTYEKYRADINKKINAKDRAAIAAALESVKLSDISSNLNRFSRGLGYAGKFTSLADWITEFGKAVRTENWRPLFVKTETIIAGNAATALVALVFSILTGSALGIIGYGLLMAVTGALIDESLVEKANKFWGI Kraken2_NZ_CP083921.1 IMICODJL_08729 Prodigal:2.6 5629 6300 + VFG042989(gb|ACI49672) 99.1 5.18e-159 (ACI49672) putative housekeeping sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKKWLFGFLGVTLIVFCSVFGYVSYQKHEGEVFKQNIEKKMPVDQINAHAKSYKEDATNVNNDMSLGQMLSIQKEAIEMGVNKQVFAQIQIPALGLALPIFKGANQYTLSLGAATYFYEDAEMGKGNYVLAGHNMEMPGVLFSDIQKLSLGEVMDLVSNDGVYRYKVTRKFIVPGYFKLIDGVPEENSFLSLPKKGEKPLLTLFTCVYTSQGKERYVVQGELQ Kraken2_NZ_CP083921.1 IMICODJL_08730 Prodigal:2.6 6353 8329 + VFG042988(gb|ACI49671) 95.1 0.0 (pilA) PilA VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MAINRYVKKAGMLVGMLGIIAGCFQGYQVHAEDVTQKTPPEKVNITVHKLMYDQGTQLNVDIDGIKNDGYTHDQYPTGVTKYNKADYGDVEFTLGNITDQVLPREDSDLTNAKVDEIVQDVEDKGSNSEYVKNATNKITSAVDENGEITFTDQPAYVNSKGNVYVVYESKSAAGLVTQKAKPMVVIAPMTDKTGSGFLKNIHLYPKNIVSKLSFELTKFGDDGADQSKQTLLKGAKFELYKGEPGKGTKLGDLVSDDQGKLTATDLTLGKYYFVEVPSEVVVGSDQEPTADQYLLGADARNDAHNKLTFEITNDGVTSDLKASYVNYKAPVIDKTVTNGTGQEHSFQIGDAVNYQGTIHIPTDIAGGADGITVNGVKSETSPYSVFKWGDTAGKGLSYVAEKADIKVTNNDGSVVLKENTDYKIENSDSGFVIDFIVNNGQVSDTVANLHGQDLKMTYNMFVNDSAEIANPLTNSVDFVYNNNPFNQEEHHEKTKADVVTYGAKFLKVDSGLFGTGIKATPLEGAEFAAKNAEGKYYGGLTDTDKDGVKEAVWVDDVANAAILKSDKEGHFEITGLTEGDYSLEETKAPENYQKLTKEISFKVDKDSYKEENRITIKNNQKASVPMTGSNGFQSYVLISCLLLGAGGLSAVVYFKKKA Kraken2_NZ_CP083921.1 IMICODJL_08731 Prodigal:2.6 8342 9097 + VFG042987(gb|ACI49670) 67.6 1.42e-112 (ACI49670) putative pilus-dedicated sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MIIRKPPKRRVMHKLMIFFWLLSAVAVYLIPVVETNVAKFQQQQRILAIENLEKTDSSLDVAKIELGDPVGVLTIPSISLKLPIYDGTSDKILENGVGITEGTGDITGGNGKNPLIAGHSGLYKDNLFDDLPSVKKGQKFFIKVNEEQHAYQIYRIEEVKAEELQKNYLDYLMPEKDQDRITLMTCTPKGVNSHRFLVYGERVSFSKEDLKLQKKAKNRKSISLDWRLALLFAFFCVPIIFIYKKIRRRSE Kraken2_NZ_CP083921.1 IMICODJL_08732 Prodigal:2.6 9094 9918 + VFG042986(gb|ACI49673) 60.8 8.32e-94 (ACI49673) cell wall-associated LPXTG-like protein VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MNKRKWLFVCVAALFSTVAYSQLSFADSSDSSTTQTIDNSITAPSETDSSENTTEETADSNISFTESTNPTSESSSETSEKPQDVEDTQVIKQAIHIQKIISSNQINNQGSQVAQQEGINGAKFIVYDITNILEEMSQDDNEKNQSVEIIESKLKDRAKKLSYDQLKKVAEGETKTIDDQEGVIEFSIEVPANKKQAYYIVNESSPENISNSEDIVLLTPVSNEKGEFLTDVWLYPKSEKSEPKEEIKKVVSTGVKKNFFENCWEFFAQLFFDN Kraken2_NZ_CP083945.1 IMICODJL_09671 Prodigal:2.6 20704 22608 + VFG045768(gb|WP_012979416) 62.4 7.85e-282 (lvhD4) type IV secretory system conjugative DNA transfer family protein VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MKIKMNNAVGPQVRDKAAKKSKVLPILGALSMGAGLQAATQYFAYAFNYQDVLGHNFNGIYAPWSILQWAGQWYSDYPDEITRAGGAGILVSSVGLLAVAIGKVVAANTSKANEYLHGSARWAEKKDIQTAGLLPRDRNFLEIVTGKDAPTATGVYVGGWEDKEGNFYYLRHSGPEHVLTYAPTRSGKGVGLVVPTLLSWGASAVITDLKGELWALTAGWRKTHARNKVLRFEPASSNGGVCWNPLDEIRVGTEYEVGDVQNLATLIVDPDGKGMESHWQKTAFSLLVGVILHALYKAKNEGTPATLPSIDAMMADPNRDIGELWMEMATYGHIDGQNHMAVGTAARDMMDRPEEEAGSVLSTAKSYLSLYRDPVVARNVSKSEFRIRDLMHADDPASLYIVTQPNDKARLRPLVRIMANMIVRLLADKMDFENGRPVAHYKNRLLMMLDEFPSLGKLEIMQESLAFVAGYGIKCYLICQDINQLRSRETGYGHDEQITSNCHVQNAYPPNRVETAEHLSRLTGQTTIVKEQITTSGRRTAAMLGQVSRTFQEVQRPLLTPDECLRMPGPKKNDKGEIEEAGDMVIYVAGFPAIYGKQPLYFKDPVFQARASIAPPKVSDRFTTFPADGEGIKI Kraken2_NZ_CP083945.1 IMICODJL_09715 Prodigal:2.6 60448 62985 - VFG045766(gb|WP_012979408) 67.2 0.0 (lvhB4) conjugal transfer protein TrbE VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MIQGITISIAVLGAVLLLILFARIRAVDAELQLKKHRSKDAGLADLLIHAAVVDDGVIVGKNGSFMASWLYKGNDNASSTDEQREMVSFRINQALAGLGNGWMVHIDAVRRPAPNYSEKGASNFPDPVSEALDEERRRLFESLGTMYEGYFVFTVTWFPPVLAQRKFVELMFDDDAVTPDHKARTKGLITQFKREISSIENRLSSAVEMIRLKGQKIVCEDDTVVTHDDFLSWLQFCITGNHHPVILPSNPMYLDAIIGGQEMWGGVVPKIGRKFIQVVAIEGFPLESTPGILAALAELPIEYRWSSRFIFMDQHESIAHLDKFRKKWRQKVRGFFDQVFNTNTGAIDQDALSMVQDAESAIAEINSGLIAMGYYTSLVVLMDEDRDALESSARSVEKAINRLGFAARIETINTLDAYLGSIPGHGVENVRRPLINTMNLADLLPTSSIWTGSASAPCPLYPPQSPALMHCVTHGATPFRLNLHVRDLGHTFMFGPTGAGKSTHLGIIAAQLRRYKGMSIYAFDKGMSMYALTKATGGRHFTVAADDGKLAFCPLQFLETKSDRAWAMEWIDTILALNGVETTPGQRNDIGHAIISMRDSGARTLSEFYTTIQDEQIREAIKQYTIDGAMGHLLDAEEDGLQLSDFTTFEIEELMNLGEKYALPVLLYLFRRIERSLKGQPAVIILDEAWLMLGHPAFRAKIREWLKVMRKANCLVLMATQSLSDAANSGILDVIVESTATKIFLPNIYARDEDTSALYRRMGLNARQIEIIATAVPKRQYYYVSENGRRLYDLALGPLALAFVGASDKESVATIQQLEAKFGDDWIHEWLSEKGLNINDYLEAA Kraken2_NZ_CP083945.1 IMICODJL_09718 Prodigal:2.6 63717 64676 - VFG045767(gb|WP_012979404) 71.6 2.38e-157 (lvhB11) P-type conjugative transfer ATPase TrbB VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MTESKEFDSIKERAKKKLERDMGPVLIAALNDPKTVEIMLNSDGRLWQERLGEGMTCIGSLRAGQAQAIIETIAGYHNKEVTRQKPILEGELPLDGSRFAGQLPPVVPAPTFAIRKKAVSIFTLDQYVADGVMSEAQKTALEKAVLAHRNILVIGGTGSGKTTLVNAIIHQMVVADHSERIFIIEDTGEIQCAAENFVQYHTSLDVTMTMLLKTTLRMRPDRILVGEVRGPEALDLLMAWNTGHEGGAATLHANNAKAGLDRLAMLISMHPDSPKPIEPLIGEAVHVVVHIARTPEGRRVQEILEVSGYSNGHYITKAL Kraken2_NZ_CP083808.1 IMICODJL_09823 Prodigal:2.6 94913 95914 + VFG005360(gb|WP_002262489) 60.9 2.71e-135 (plr/gapA) type I glyceraldehyde-3-phosphate dehydrogenase VF1042 Streptococcal plasmin receptor/GAPDH VFC0001 Adherence MKKIGINGFGRIGRLVLRRILEQQEAVEVVAINDLTSPEMLAYLLKYDSNYGAFHGDVGVDGNALLVNGKKITVFAEKEAKNIPWGSLGVDVVIECTGFYTSAEKAQAHLDAGAGKVLISAPAGEMKTIVYNVNHDTISAEDKIISVASCTTNCLAPMAKALHDNFGIKVGTMTTIHAYTGTQALVDGPRGKDFRSSRAAAENIIPHTTGAAKAIGLVIPALTGKLKGHAQRVPTKTGSVTELVSVLDKKVTVDEINAALKRACENNESFKYTEDQIVSTDVIGVPYGSVFDATQTEISEAGDLQLVKTVSWYDNEYGFVTQLVRVLHLYVSL Kraken2_NZ_CP083808.1 IMICODJL_09979 Prodigal:2.6 265197 266576 + VFG044201(gb|WP_011267793) 69.0 3.11e-227 (PSYR_RS13390) diaminobutyrate--2-oxoglutarate transaminase VF0922 Achromobactin biosynthesis and transport VFC0272 Nutritional/Metabolic factor MTDKVRIDSLDATSNANNETYLARQAEFESNVRSYPRKLPLAITQAKGVWITDADNKEYLDCLAGAGTLALGHNHPDVLQSIQNVITSGLPLHTLDLTTPLKDAFSEYLLSLLPGQGKEYKLQFTGPSGADAVEAAIKLAKKATGRSGVIAFSGGYHGMTHGALSVTGNLSPKEAVNGMMPEVQFMPYPHLYRCPLGIGGEAGVKALTYYFENLINDVESGVRKPAAVILEAVQGEGGVNPAPAEWLQRIRKVTEEHGILLIIDEVQAGFARTGKFFAFEHAGIQPDIIVMSKAVGGGLPLAVLGIKKQFDAWAPGHHTGTFRGNQLAMATGLTTLKILKEQNIADKVAQQGEWLKGKLAEMQKRFPVIGHVRGLGLMIGIEIVKPNEAKDQLGCYPADGDLSALLQKKCFEAGLILERGGRHGCVLRLLPSLLITNQELEVFLDKFEQALLAAGVQPV Kraken2_NZ_CP083808.1 IMICODJL_09995 Prodigal:2.6 279974 281155 - VFG024081(gb|WP_014941434) 63.7 2.51e-155 (narH) nitrate reductase subunit beta VF0302 Nitrate reductase VFC0272 Nutritional/Metabolic factor NarX function as a respiratory fused nitrate reductase (three different domains present in this protein encode the difference subunits of nitrate reductase: the N-terminal domain showing similarity to narG, the central domain showing homology with narJ and the C-terminus showing homology to narI); NarGHJI is a membrane-bound nitrate reductase complex; NarK2, a putative nitrite-extrusion protein Nitrate respiration helps the bacteria to survive in O2-depleted areas of inflammatory or necrotic tissue MKIRSQVGMVLNLDKCIGCHTCSVTCKNVWTSREGMEYAWFNNVESKPGVGYPNAWEDQEKWRGGWIRNIKGRLVPRLGSRSSVLMKIFANPVVPGIDDYYEPFTFDYQHLHTAKAGKNQPTARPRSLISGQRMDKIQGGPNWEEILGGEFSKRSADKNFDAMQKEMYGQFENTFMMYLPRLCEHCLNPACAATCPSGAIYKREEDGIVLIDQDKCRGWRLCVSGCPYKKIYFNWKSGKSEKCIFCYPRIESGMPTVCSETCVGRIRYLGVLLYDADKIAEAASTEQETDLYQRQCDVFLDPFDPQVIEEALKRASRKALSMPRRRRRCGSWRWTGSWRCRCIPNIARCRWSGMCRRCRRFSRWPTRAGWCPRPACCRTWKACAFRCNTSLTC Kraken2_NZ_CP083808.1 IMICODJL_10025 Prodigal:2.6 313386 313898 + VFG048726(gb|WP_012968407) 66.5 2.06e-78 (tli1) type VI secretion system immunity protein VF0569 T6SS VFC0086 Effector delivery system Type VI bacterial lipase/phospholipase effectors (Tle) has been sub-divided into Tle1–Tle5. The Tle1–Tle4 families exhibit the GXSXG motif, while Tle5 present a dual HXKXXXXD motif Antibacterial activity The type VI membrane-targeting phospholipase effector Tle1 and Tli1 immunity proteins play a role in intraspecies antagonism MNPCNRTLLTGVVLLLTGSPIAFAGTIEAINHTKWAINHFSVNGQSGLDAIGPFQGGGGGCCYHAPPLWKPGITVKVDWETGVGSSEGFPGFQDREKYLAWVKKLETQKKQHSRMIPLPPYTSTEKTCGITVHFLPCDQVKVTTSCADYGSPAYPVNYPIQMKEPAVCPK Kraken2_NZ_CP083808.1 IMICODJL_10074 Prodigal:2.6 365990 368179 + VFG048540(gb|WP_014228993) 73.9 0.0 (iroN) salmochelin receptor IroN VF0563 Sal Salmochelin VFC0272 Nutritional/Metabolic factor Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection Inducing dissemination through chelation of host cellular iron, leading to inactivation of iron-dependent prolyl hydroxylases and the master transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) stabilization in lung epithelial cells. HIF-1alpha controls vascular permeability and inflammatory gene expression MNVTVDFRKRPCALLMVGMLSATGVGAAEETEKLADDETMLVTAEQILKQQPGVSTITAKDIEKSPPVNDLSDIIRKMPGVNLTGNGASGSRGNNRQIDIRGMGPENTLIMIDGVPVSSRNAVRYSWRGERDTRGDTNWVPPEMVERIEVIRGPAAARYGSGAAGGVVNIITKRPTNDWHGSLSLFTNQPEDSKEGATKRANFSLSGPLAGDALTMRLYGNINKTDGDAWDINTAENGSYAAGREGVRNKDINGVLSWKITPEQILDFSYGYSRQGNIYAGDTQNSNGNNSANGLVESLVGSETNRMYRQSYGLAHNGIWDWGLSKLTFNYEKTNNTRLQEGSGGSVEGMINSDKFATSQLESYRGNAEINFPLDWLREQTVTLGAEWNHDKLNDPASMQAANQAGVNIGGVSGNAADRSSKNSATLSSLYFEDNIAATDSTEIIPGIRFDYHNSFGANWSPSLNLSQGLGDDFTLKAGIARAFKAPNLYQSTEGYLLSTRGNGCPKDITSGSCYLLGSDDLEPEVSVNKELGIEYAHEGYVAGITWFRNDYKNKIVSGRERVGIASNGYNILRWENGGKAVVEGLEGNLTVPLIADRLEWRSNATYMLKSEDKETGNPLSIIPEYTINSQLEWQITSDLSGDINWTMYGRQKPREFSESRLEVNNLSQREIGAYSVVGLNLNYDLTKNLRANAGVSNLLDKRIYRENDGASTYNEPGRAWYAGVTYSF Kraken2_NZ_CP083808.1 IMICODJL_10108 Prodigal:2.6 397011 398753 + VFG048600(gb|WP_004213920) 64.0 1.08e-256 (iucA) aerobactin Synthetase IucA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MDGFSQPAGVDVAAQCFLNALLRETRDWNYVAGGAPERTHFIELPLSSSQVLRLPLRYFSPTQHHHYQFPALLISPTSPEGEAVSFDTLVSLIVAKPAIRAELSGEVIERFQQRVGESHANCWQAINLRHRWPALRKKPLSFSEAEQALLVGHAFHPAPKSHEPFNEAEARRYLPEFASDFPLHWFSVDSDHVAGESLGLTLRARLLRFAAQSAPALLSQFTDQRWLIPMHPWQARYLLTQAWCQRLIASGALADLGESGTAWLPTSSSRSLYSPASNDMIKFSLSVRLTNSVRTLSVKEVKRGMRLARLAQTPRWQRLQMDYPTLRVMQEDGWAGLRAADGAIQEESLMAFRVNSLFDTPETQTNVLVSLTQAAPDGGDSLLAAAVRRLSHRLGLTLSQGAQCWVNAYCDRVLLPLFATEANYGLVLLAHQQNILVEMQQDLPVGLLYRDCQGSGFTENAADWLAQIDETDAENCFSREQVLRYFPYYLLVNSTLAVTAALGAAGFETEERLMAQVRDRLTALRSQVSDTRSLDYVLDSRHWNCKGNFYCYLYDHNENTIADPAVIYFDFHNPFYREKP Kraken2_NZ_CP083808.1 IMICODJL_10109 Prodigal:2.6 398753 399700 + VFG033986(gb|WP_001287501) 63.2 1.1e-155 (iucB) aerobactin siderophore biosynthesis protein IucB VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MPNAHIVHGDAGFRCALTGQALPLMLGLDNSASLPLMPTIPDGWLADAIDQLLVAAPQLSGVHLPWAQWHHNPQAQALFAAVNGDYFSRDTFWQLPLWLRGEQPTASGKMQFDEARQIFYPVRPPRPDGEIYRRYDPQIKRTLSFRVADVAEDAVRFTRWMNAPRVNAFWEMAAPQPEQESYLRKQLDSAYCFPVIGCFDDQPFGYFEIYWAAEDRIGRHYRWQPYDRGLHMLVGEEAWRGAHFIRSWLRGLTHYLFLDQPRTQRIVAEPRYDNQRLFRHLPVAGYQTLKEFDFPHKRSRLVISERSRFFTEVGL Kraken2_NZ_CP083808.1 IMICODJL_10110 Prodigal:2.6 399697 401424 + VFG048606(gb|WP_004213922) 67.0 3.42e-281 (iucC) aerobactin siderophore biosynthesis protein IucC VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MMWARVNREMIAKILAELEYERTLRAVERSAGRWEITVGQARWEFAASRGIWGWLHIDADSLSGGPMEADALLRQLAVTLEMSDAQTAEHLEDLYATLRGDLQLLEARRSLSADDMIALDADELQCLLSGHPKFIFNKGRRGWGVDALRAYAPEYRNRFQLHWIAVRREKLVWSHEEACDLSALLASAMDEAELARFYQHWQSAGLDESWIALPVHPWQWQQKIALHFLPHLARREMVELGVFGDRYLAQQSLRTLTNASRPARFDIKLPLTIYNTSCYRGIPGRYIAAGPLASGWLRQQFAQDQTLRATGAQILAEPAAGYLPHEGYAALPAAPYRYQEMLGVIWRESPASYLQPGEQAVLMAALMETDNAGRPLIDAWINASGLDAASWLSRMFEVVVIPFYHLMCRYGVALIAHGQNVTLVMKDHIPQRILLKDFQGDMRLVDADFPEAASLPAAVKEVTARLSADYLIHDLQTGHFVTVLRFISRLTLRSGIDERQFYRLLASVLQRYMAQHPAMADRFALFDLFKPRIIRVVLNPVKLTFSEHDGGSRMLPNYLTDLDNPLYLVTQESPK Kraken2_NZ_CP083808.1 IMICODJL_10111 Prodigal:2.6 401421 402746 + VFG048609(gb|WP_004213923) 63.9 9.280000000000001e-195 (iucD) lysine 6-monooxygenase IucD VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MKIYDFIGIGVGPFNLSVAALAEGLEGFSSLFLERKAHFAWHPGMMVPDCAMQTSFLKDLVSAVEPTSRYSFVNYLVQQKKFYRFLTTEQRTVSREEFSDYLGWVAKRLSNLAFNQPVTRVTFNDATRLFTVETAQDRFLARHICLGIGKQARLPACVTQQSDRCFHASEMMLRRPDLHGKRVTIVGGGQSGADLFLNIFRAEWGQPAALNWVSRRNNYNALDEAAFANEYFTPDYLESFSTLDASARQLMLNEQKMTSDGITSESLLAIYRAMYHRFEVLREQPWARLMPSRSVISLDQTQEAQQLRLRHHLDHGEEQLATDVVIFATGYRSSRPAFLAPVAHRLQLDRDENFQINTDFTLNWDGPESNALFAVNAGMQRLGIAEPQLSLMAWRAARILNRAHPDEPFELSTTPGVIQWRTQQPENHVRDPQHTVNTVQF Kraken2_NZ_CP083808.1 IMICODJL_10112 Prodigal:2.6 402771 404960 + VFG048611(gb|WP_014228851) 71.2 0.0 (iutA) ferric aerobactin receptor IutA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MKQPYLWVLNPCLLAMLSSGAWAEEIKEDQMVVSASRTHRSVAEMAQTTWIIEQQEIEQQVQGGKELKEVLAQLIPGMDVSSQGRTNYGMNMRGRSMMVMVDGVRLNSSRSDSRQLDAIDPFNIERIEVISGATSLYGGGSTGGLINIVTKKGQPGTQAELQTGVKSGFNSHNDRDENLAAAVSGGDDKASGRLSVAYQRYGGWYDGKGNETIIDNTQTGLQYSDRLDVMGTGTLNIDESQQLQLTTQYFKSESDGRHGLYLGENFSAVTGSGRAYNSGNLDSDRLPGTERHLINLQYSNTDFFGQDLVAQVYYRDESLTFYPFPTLSRNRVSSIGASQQKTDFYGGKLTHNSQPVDALTLTYGVDADHETFDANQQFFDLNSAAQSGGMTLKNAYNVGRYPGYSITNLAPFLQSSYDIDTITLSGGVRYQYTKNKVDDFVGYAQQQAIASGQASSADAVPGGSTDYNNLLFNAGILGRLTERQQLWFNFSQGFEIPDLAKYYGSGTYRLANGHYNLTNSVNVNDSKLDGIKVDSYELGWRFTGDSLRTQLAAYYSLSDKTISINKSDMTINLDDDKRRIYGVEGQVDYFFDNSEWSSGANFNIIKSETRVEGKWEKLTIDSASPSKVSAWLNWAPGDWDLRVQSTQTFDVSDADGKKIDGYNTVDFLGSYALPVGKLSFSVENLLDKDYTTVWGQRAPGLYSPTYGDAALYTYKGRGRTFGLNYSVLF Kraken2_NZ_CP083810.1 IMICODJL_10422 Prodigal:2.6 181668 183053 - VFG034652(gb|WP_000074204) 72.3 5.13e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPAAPVPQQFSLSHNSLTPAVNGYRDTGWRNFFVDPQVTRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDARLELSYELDFFGKLKNMSDADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAANANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_CP106965.1 IMICODJL_11107 Prodigal:2.6 78764 79594 + VFG014116(gb|NP_251832) 63.5 1.01e-34 (PA3142) hypothetical protein VF0085 LPS VFC0258 Immune modulation Two distinct forms of LPS: A-band and B-band. A-band is a homopolymer of alpha-linked D-rhamnose, whereas B-band LPS is a heteropolymer Mediates biological effects including resistance to serum killing and phagocytosis; the binding to normal CFTR (cystic fibrosis transmembrane conductance regulator) and invasion of host cells may make a contribution to virulence in the human eye; internalization by binding to normal CFTR protein expressed by airway epithelial cells followed by desquamation of bacteria-laden epithelial cells, constitutes a host defense mechanism. If this mechanism fails to function properly, abnormally high bacterial carriage would promote the establishment of chronic bacterial infection Binding interaction occurs between the first extracellular loop of CFTR (predicted to be in amino acids 108-117 of the mature protein) and the complete outer portion of the core polysaccharide of the LPS MLMCDATGLSQRRACRLTGLSLSTCRYEAHRPAADAHLSGRITELALERRRFGYRRIWQLLRREGLHVNHKRVYRLYHLSGLGVKRRRRRKGLATERLPLLRPAAPNLTWSMDFVMDALSTGRRIKCLTCVDDFTKECLTVTVAFGISGVQVSRILDSIALFRGYPATIRTDQGPEFTCRALDQCAFEHGVELRLIQPGKPTQNGFIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPHSALNYQTPSEFAARWRNGKCEGKQTDLTN Kraken2_NZ_CP061863.1 IMICODJL_11351 Prodigal:2.6 3311 3757 + VFG007179(gb|WP_005464682) 73.6 5.67e-74 (vxsC) transcriptional regulator ExsC VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MSARQIVDEVLLKFAHQIGLPKLQLIEDELGLAFDDNLRVHVIFHPTTEMLQLEAEIVDLQIINSDLYRSFIAFNYHWSEHQLFFSLDNHRHKLCLNRLLHAESLDYELFEDALAELLTQSESWEDLLSAHIAMKALPSQFQSSDLIV Kraken2_NZ_CP061863.1 IMICODJL_11361 Prodigal:2.6 12462 13343 + VFG007177(gb|WP_005464548) 84.2 7.35e-167 (exsA) transcriptional regulator ExsA VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MDVLGQLNTERGNSLSRKIHSTCHYEKYDEVFHSRQSHIVVVHNGQLQVQTGDCTLDVVAGCGVFLYQGDYLLEYTPVDGQYTASVIEFDNELVSQFLQKHSDLLMSLPKVDNVQSGLFPFTFNLLIEQTLSGIKTLEEQSYPDTIMRLKYEEMLILLLHGEQGENLYALLSQLTNKTSDRLRRFMELHYLKEWKLTDYAQEFGASLTTFKELFNEHYGVSPRAWISERRLLYAHKLLLTSKMSIVDVAMEAGFSSQSYFTQSYRRRFGTTPSRVRSGMNKWFCRKVRELDNS Kraken2_NZ_CP061863.1 IMICODJL_11372 Prodigal:2.6 20397 21455 - VFG007165(gb|WP_005477705) 88.1 1.12e-208 (vscU) type III secretion system C-ring protein VscU VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MSGEKTELPTPKKLRDARQKGQVAKSQEVVSSALILALIAVLFAFADYYMLHISALLLLPSELAYQGFQDALLDVAIAIAKEMVYLLAPILIVAALIAIMSNMGQFGLLFSGESVKPDIKKINPVEGAKRIFSLNSIIEFIKSILKVSLLSCIIWVTLRDNLNTLLQIPACGLECVPTITSVLVKQLMIISSVGFIVIAAADYAYQKFDHTKQLKMTKDEVKREYKEMEGSPEIKSKRRQLHQELQASNQRDNVKRSSVLVTNPTHIAIGLYYKKGETPLPVITLKETDAMAKRMIAIAHEEGVPVMQKVPLARALYADGQLNQYIPGDLIETTAEILRWVASLEQSEESRV Kraken2_NZ_CP061863.1 IMICODJL_11373 Prodigal:2.6 21474 22256 - VFG007164(gb|WP_005464642) 86.9 6.400000000000001e-158 (vscT) type III secretion system C ring protein VscT VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MSYDDLHQALFLYSLTLPRLMACFIFLPILNKQTLGGTLVRNGVLCSLALFIFPMINQQELPAETDGIWLMVILGKEVLLGMLIGFVAAIPFWAIEVAGFLVDNQRGAAMASMFNPTLGSQSTPTAVLLTQTLITLFFSGGGFVAFIYALFNSYSSWPVISFFPTVTEEWVYFFYAQFEQLMWLGVLMSAPLVLAMFLAEFGLALISRFAPQLNVFSLAMPIKSAIASVLLIVYLALMMDHFQALFSDIVLFREQLNTIW Kraken2_NZ_CP061863.1 IMICODJL_11374 Prodigal:2.6 22253 22519 - VFG007163(gb|WP_005464497) 90.9 1.75e-49 (vscS) type III secretion system C-ring protein VscS VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MNPAEMIHFTTQALTLVLFLSLPPILVAALVGTLVSIVQALTQVQEQTLGFVVKLIAVIITLFVTSQWLGAELHSFATLTLDKIPQIR Kraken2_NZ_CP061863.1 IMICODJL_11375 Prodigal:2.6 22533 23183 - VFG007162(gb|WP_005377232) 95.4 1.15e-138 (vscR) type III secretion system C-ring protein VscR VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MIQLPDELNLIVTLALLALIPFIAMMATSFVKLTVVFSLLRNALGVQQIPPNMAMYGLAIILSIFIMAPVGFETYDYVTQHEISLEDSESIKGLIESGLQPYREFLKKHIRETESVFFTDAARTLWPQKYVDRLESDSLLLLLPAFTVSELTRAFEIGFLLYLPFIAIDLIVSNILLAMGMMMVSPMTISLPFKLLLFVLLDGWTKLTHGLVLSYG Kraken2_NZ_CP061863.1 IMICODJL_11376 Prodigal:2.6 23180 24145 - VFG007161(gb|WP_011105899) 70.1 7.04e-166 (vscQ) type III secretion system cytoplasmic protein VscQ VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MILDFPKVEPSSIALSNQLCAKQCHFQDSQSNSLSVTLGQKPEFSGYRLTLLIGGQTILIDFSGAQLQQWLHGILDSTAFESLPNSLQLALLSSQIEPYTDMIKRLFGQLPALSKLQVHEQPASEENVLMLTINRDDVSLSLWVHEGRDVLIDTLPQAPSYLSQNIALPFWLSFGKTRLALSQFEQFELGDVVFFDDCYIAQHQVLLQVSNHNLWRCQLDNTTLHIQEKETNMNDINSSEALTDHQQLPIELTFDVGQQTITLEQLNALQPGFTFELNQSISNPVTMRANGKIIGECELVNINERLGVRVLELFGGSQEPA Kraken2_NZ_CP061863.1 IMICODJL_11378 Prodigal:2.6 25249 25710 - VFG007159(gb|WP_005464592) 74.0 2.73e-41 (vscO) type III secretion system protein YscO VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MIEQLLEIKKIRADRADRAVQQQEYRVSNARASLRKAEQSVVDYRQWREEEEERRFAKAKQKTVVLKELEILRQEIALLREREADLKQRAAEEKKSLEQENQRLKERKQEALAADKTKEKFIQLNEQEIAEQARQVQYQEELEQEEFRSVVVS Kraken2_NZ_CP061863.1 IMICODJL_11379 Prodigal:2.6 25707 27029 - VFG007158(gb|WP_005477722) 94.3 1.59e-294 (vscN) type III secretion system ATPase VscN VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MNDLSYIAETQQSAIKQTRLIQIRGRVTQVTGTIIKAVVPGVRVGELCELRNPDQTLSLLAEVVGFQQHHALLTPLGNMFGISSNTEVSPLGKMHEVGVGDHLLGKILDGLGRPFDGSQSTEPSAWYPVYRDAPPPMQRKLIEKPISMGVRSIDGLLTCGEGQRMGIFAAAGGGKSTLLAKLIRSADVDVTVLALIGERGREVREFIEHDLGEKGMARSVLVVATSDRPAMERAKAAFVATSIAEYFRDQGKRVLLLMDSVTRFARAQREIGLAAGEPPTRRGYPPSVFAALPKLMERAGQSDKGSITALYTVLVEGDDMTEPVADETRSILDGHIILSRKLAAMNHYPAIDVLRSASRVMNQIVDKTHQASAAHMREMLAKYEEVELLIKIGEYQHGADSRADMAIAQGDDIRVFLRQGTHEPSELEETVTQLSGLAGL Kraken2_NZ_CP061863.1 IMICODJL_11380 Prodigal:2.6 27216 28109 + VFG007157(gb|WP_005464652) 81.8 2.33e-169 (vopN) type III secretion system protein VopN VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MSTINSQILTGNKFDAPIRSNLEFSRTGASVNGNYRGETVRAHNATQSLFDAMEELTALGSEKAEKDLTKRKVKDGSIRVNEAHELVSDYLRKVPDLEKNQKIKDLATKMASGNLSTIAQLQAYLNGFSEEKSHQYLALQAVKKFLGTNPESKSLLALIDQAILTFEQNLDSWAQINTEIRVSSFADEYSQEQGFSSLHQLRGFYRDTVHSYQGLSSAYKDVVERFGAKEVSTAVEFMLQGMSADLSVQGSSIDSVKLQLLMSDMQKLKTLNTLQDQVSNLYQIFKPQQANYGLSSY Kraken2_NZ_CP061863.1 IMICODJL_11381 Prodigal:2.6 28090 28374 + VFG007156(gb|WP_005464474) 78.7 3.13e-48 (tyeA/vcr1) type III secretion system regulatory protein VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MAYQVTNLMSDVIALVEQRWVESAEIWNLVNAMELASTEQKISFFRELHKLIRHIPIDVFNDEEQRQNLIQAVQKALDEAIDLEEEEMWDDELD Kraken2_NZ_CP061863.1 IMICODJL_11382 Prodigal:2.6 28361 28735 + VFG007155(gb|WP_005477854) 78.0 1.97e-67 (sycN/vcr2) type III secretion system regulatory protein VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MNWIDESVDDFCRGMGLEAVDFSSAGRVQLSFEQSGTLHIEKHQDCLFLMLAKTLPWHQSNEPIKKALSFCHAGQGWPFLIKTGLLDEQTLVFSAQIEGDEVTLPTIEQAFALQVRLHKEVAGS Kraken2_NZ_CP061863.1 IMICODJL_11383 Prodigal:2.6 28732 29109 + VFG007154(gb|WP_005464441) 73.6 2.2399999999999998e-60 (vscX) type III secretion system C-ring protein VscX for secretion specificity VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MSRISTLNVGIEGFTHVSLEQVENGFPQRFQLLPDGQAIATHIEKLYELRPSEQYLMSLARPKLTHLELLRPDKYRQQFDTTQQRLQELAQKNGSHALNQALETLQSTKLDQRYLTMALNLLIQV Kraken2_NZ_CP061863.1 IMICODJL_11384 Prodigal:2.6 29115 29441 + VFG007153(gb|WP_005464454) 67.9 4.33e-49 (vscY) type III secretion system C-ring protein VscY for secretion specificity VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MLQTKDVELLLIHAALQVQYQKPEQAITLLDALLEIEPQHQEVRQTLAVACLNSGRYTRSIELCESLLKTEHSNKAGLWFCLSQARWKQQDVEGARHAHRRYLQSLNN Kraken2_NZ_CP061863.1 IMICODJL_11385 Prodigal:2.6 29446 31569 + VFG007152(gb|WP_005464675) 93.2 0.0 (vcrD) type III secretion system C ring protein VcrD VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MNKLKLIDILNKAGQRKDIMLAVMLLAIVFMMILPLPTALVDVLIGTNMSIAVVLLMLAIYITTPLEFSAFPAVLLITTLFRLSLSITTTRLILLQGDAGQIVYTFGNFVVGGNLVVGIVVFLIITIVQFMVITKGSERVAEVGARFSLDAMPGKQMSIDGDMRAGVIDVHEARHRRSLIEKESQMYGSMDGAMKFVKGDSIAGLIIIVVNILGGVTIGVTQKGMSASEALELFSILTVGDGLVSQIPALFIAITAGIIVTRVSNEDSSDLGSDIGGQVTAQPRALLVGGVLLILFALIPGFPKVTFLILAAIVGGGGFFLFYQQKKQSESDSSDLPRFVAQGAGSPAAKPNRPTSSRNSKGKLGEQEEFAMTVPLLIDLDSRLQESLEAVALNDELARVRRALYLDLGVPFPGIHLRFNEGMSNGEYLIQLQEVPVARGRIESGKMLVTEGNEQIDLLGVPYENDDDFLPGIVSIWVDHSHREKLQNSHVGFLTPDCILTYHLSHVLKEYAQDFIGIQETRYLLEQMEGSYSELVKEAQRIVPLQKMTEILQRLVSEDISIRNLRVILEAMVEWGQKEKDVVQLTEYIRSSLKRYICYKYASGQNMLPAYLLDQSLEDTIRNGIRQTSAGSYLALDPSVTQQFVSDVKQTIGDLSRMPNKPVLVVSMDVRRYVRKLIESEYYELPVLSFQELTQQINIQPLGRVGM Kraken2_NZ_CP061863.1 IMICODJL_11386 Prodigal:2.6 31569 31982 + VFG007151(gb|WP_005464560) 80.1 1.31e-76 (vcrR) type III secretion system protein VcrR VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MACELAQSLMASGVEVTPYFWQKSTILLGQRYECDGMELVFRVEEGEIIIVLLRRVSPNQGLSNPFSALFLLAEHALRLYPLDWSIRGNVDVLRSSNMNSQRLAQFYLRACGASHDEQEDWYFLRLSDYRPLKKRKK Kraken2_NZ_CP061863.1 IMICODJL_11387 Prodigal:2.6 32043 32333 + VFG007150(gb|WP_005464408) 74.0 3.65e-43 (vcrG) type III secretion system chaperone VcrG VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MKQPFTEAIEKSELAIRNAEDRTDVFNELLEGLGVGPVAGNILLDGLNASPQLMKQAEHELLEEVQRRRQQQHQVQATSTKGSRRKRPAIMRGMVI Kraken2_NZ_CP061863.1 IMICODJL_11389 Prodigal:2.6 34174 34665 + VFG007148(gb|WP_005464462) 93.2 8.14e-106 (vcrH) type III secretion system chaperone VcrH VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MSTQNVATDPYQMQAEELLSFLEEGGTLKILHDISADTIEHIYAVGYKFFQSGKVEQAAKVFQLLSMLDHYQARFFIGLGAARQELGEYLQAIDAYSYAALVDINDPRPPFHSAECHLKLEQLTEAESGFYSAKKMSAGKSEYADLHQRADIMLEAVRNKRSN Kraken2_NZ_CP061863.1 IMICODJL_11390 Prodigal:2.6 34669 35868 + VFG007147(gb|WP_005464635) 63.0 5.4799999999999994e-89 (vopB) type III secretion system translocator protein VopB VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MSYIALTRTQSQLYTSDSGQTTLDKVTKTAPNSSPSVTTENVKGKNVEVLNAGKVKVQLDSPNAAVSDKITNLTLKEMTQLQELVDLKKQVLSIDSTNVGLIAVKIISGSTNDFEVELAAITDKLKRTQNELKIQEIKVAKAKHEQEMSENLSKIKESEEALQKAEKAGLASKIIGWFAAIASIVVGSILVATGFGAAVGGLMIAGGVMGVISMTLQEPAVNEALVEAGVDVDTLNKIVVALEIIVAIVSVIVTFGGSAAGSLAKFAAKSAAKIAQKVAEVAARVAANLAKLAAMGSTAATTTAKAFRFGTEAVDIITSASKGTTDAVLSARKANTAQIQAEITEQKAAMAFSQAVLDKLKEEIAKLIEDFQELMSVIMQMIQAKGETLQAVMSRPATV Kraken2_NZ_CP061863.1 IMICODJL_11391 Prodigal:2.6 35878 36738 + VFG007146(gb|WP_005464399) 64.1 2.64e-127 (vopD) type III secretion system translocator protein VopD VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MLDKIGNTGRTDLYGLGELDKSTKAEKAPETKTEAAAIRGNGEAAVSGPKHYQLDGPKAPAIGDQARVVEKLMSALAPTVNLLMQTTEKALNGEQVIKSPSEVVSQSLSLLTLLYQVSKLSREQQVLQREIAVEANVASLKSQAEELNNSAKAMIAMAVISGVLAGITAIVGVVSSMKAGKYIKQEAAGSAIAANKFQKQMATNNTVNTVIQSIGQMANSAANVEQTKAQARSKEDEILATRAQASKQKADENVGFQEGLLKELRELFRSISDSQNQAWRASIPTV Kraken2_NZ_CP061863.1 IMICODJL_11394 Prodigal:2.6 39004 39981 + VFG007176(gb|WP_011105907) 67.2 1.64e-159 (exsD) transcriptional regulator ExsD VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MKKLHWRRRSRYPNNIVTQRKVTVLQRGVRYEGLTQSSQVPNVVNINHRQLLSEEVLSSEQLSLLLRLLDRNVVDCLCASQVVKTYQRFGTSLDRFAMRLFLEVGGQLSNNHVLSSFEQRLDYINCQLGFRFNLASPKTLILSMYLTLNEWVNRKTDQTVLHDTIQLEQLINQLSIQKDYWLRLSTEENSAIFAKQQLALNQSQQSELPDFVVLNEQQNQAVESHQAMVEEWKPTLDKLKGLSQYGETSDKFISEWKVWCGEARVQVPELNDVWDACDHVYSDLNAVAKIWQWFQDMHTVGNVDHYYFDIQSNQCGQVCNHLSQI Kraken2_NZ_CP061863.1 IMICODJL_11396 Prodigal:2.6 40422 42293 + VFG007174(gb|WP_011105906) 82.1 0.0 (vscC) type III secretion system OM ring protein VscC VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MLAVLKKQLRRLVWSVACTLSLLAALSLHASELDWPDQPFRYYANNDSLKELLNNFGANYRVSVSVSDKVNDRVSGRFTPEDPAEFLDYLAQLYNLMWYFDGAVLHVYKATETRSRLLQLELLTANELRSTLISTGIWDSRYGWRAAENKGLVYLAGPPRYVDLVVQTAEALESRLVQKSNSTDELFVEIIPLKYASATDREITYRDQVVTVPGIASVLSRVLSGVQTQIKATKESEETDINTAATTTKNVSVHGGASVEAEPGLNAIIVRDTQARLPLYRKLVAQLDQPQSRIEVALSIVDISANDLSQLGVDWRAGIAVGNNSILDIKTTGDVDGGDVTLGSGQTFKSLLDATNLNYLLAQIRLLESQGSAQVVSRPTLLTQENVEAVLNNSSTFYVKLIGREIAALEKVTYGTLLRIVPRIVGDRFVERPEINLSLHLEDGAQIPDGGVDNVPSIRKTEISTLATVKQGQSLLIGGVYRDEVSHQLRKVPLLGDIPYLGALFRNTTDTTRRTVRMFIIEPRIVVDGIGDNVLIGNEYDLRPKLGTLNNISNNSAELKSALALYSCTSQVQAERHQQDLLSQGKSSLLSQCELPSGQKGWRVQIKECDGSENHCARPLEEQ Kraken2_NZ_CP061863.1 IMICODJL_11397 Prodigal:2.6 42299 43600 + VFG007173(gb|WP_005477850) 78.5 1.85e-248 (vscD) type III secretion system IM ring protein VscD VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MQQWKIRILSGVHAGVEITLPNDSLVLGSDDFTADLVLTDSDIKASHLVLVCDGDTVLLRDCDEVSINNESVTVDANEIELSRNALVSVGRLTFAVGHLEDDLAIDITTEAAEKQATPVSHKPSSGWKRTVLIGLMCSLIPSMIFAGVWYSQIRASNSDAITEAEPIVLVRNILSELKLNDVRVEWNATARQAVLEGYVEDRTAKLQLLGRIDALGINYKSDLRTMEEIRRGVRFILRNLGYHQVKVENGEETGTLLLTGYIDDASRWSQVEQILERDVPGLVAWKAELQRAGAYIDTLKALLEKAELLKKVQLVTSGDRIEVRGELDDIETTRFYGVTRDFREQYGEKPYLVLKSIPKVSKGTNIDFPFRSVNFGQVPYVILTDNVRYMVGARTPQGYRISSVTPSGIELVKGGRVITIDLWYEGENTNDKS Kraken2_NZ_CP061863.1 IMICODJL_11399 Prodigal:2.6 43810 44058 + VFG007172(gb|WP_005464566) 85.4 8.37e-43 (vscF) type III secretion system needle protein VscF VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MSFYDASNRVYLDDVKTKLEEQAKAANEAVNKAIKNLETNADDPSKLAELQHTINKWSVIYNINATTTRAIKDVMLSILQKV Kraken2_NZ_CP061863.1 IMICODJL_11400 Prodigal:2.6 44062 44418 + VFG007171(gb|WP_005477707) 69.5 1.1699999999999999e-52 (vscG) Type III secretion system chaperone VscG VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MEKDMRLLLAETALMATGMHRHEEAETIASCLESQGDTEEVVAMIRSMSLMNRGRYKEAHRLLEPVCVNSPDLVCLAALAAGKAGLASKAESWLAMASKGSEENQAFATSFSQDIRNL Kraken2_NZ_CP061863.1 IMICODJL_11402 Prodigal:2.6 44948 45292 + VFG007169(gb|WP_005464519) 92.1 3.4199999999999997e-68 (vscI) type III secretion system inner rod protein VscI VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MINTQYTEVMQTNLEQVQDAQAQDGLSERFDQAMLAPEGKNGLEGGLLENISELKNTIDNAKSSLTDSMKMVGDDPAQLLQMQWALTRITFQEELIAKTVGKTTQNVETLLKAQ Kraken2_NZ_CP061863.1 IMICODJL_11403 Prodigal:2.6 45295 46101 + VFG007168(gb|WP_005477718) 86.2 3.43e-145 (vscJ) type III secretion system IM ring protein VscJ VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MMKAIVMTKAVVTMKSVITRKTMRAVSMLLVLFLVGCQAELYTGVSQKEGNEMLSVLLSEGVVATKEPDKDNTVKLMVDNAQIVFAIDALKRKGYPREQFSTLKEVFPKDDLISSPLAERARLIYAKSQELSATLSQIDGVLVARVHVVLKDQNLRPVRPGERPTPASASVFIKHAADVALDSYVPQIKLLVNNSIEGLNYDRISVVMVPSSEVRVTPQGNQFESILSIQVTKDTASHLIVILVFLVLLIIGSNVATFAWCRRNVKRG Kraken2_NZ_CP061863.1 IMICODJL_11405 Prodigal:2.6 46738 47373 + VFG007166(gb|WP_005464499) 86.9 2.87e-123 (vscL) type III secretion system cytoplasmic protein VscL VF0408 T3SS1 VFC0086 Effector delivery system Chromosome I encoded; similar to the Ysc secretion system in Yersinia; T3SS1 genes are positively regulated by VP1699 and negatively regulated by VP1698 T3SS1 uses a multifaceted mechanism to cause the cytotoxicity of host cells, involving the induction of autophagy, cell rounding, and cell lysis. The T3SS1 effector VopS could act to covalently modify a conserved threonine residue on Rho, Rac, and Cdc42 with adenosine 5'-monophosphate (AMP). The resulting AMPylation prevented the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in the infected cell. MVSFVEIKTDNLQLAPGLKVLKAKDYVSYLDSQHLVEAARSKAESIITKADEAYELERQRGYQDGIDQAKIENAETMLATLARCNEYYLQVEQKMTSVVLDAVRKIINSFDDVDTTASVVREALQLVSNQKQVILHVHPEQVTEVREKVSSILSDFPEVGYVEVIADARLKNGGCILETEVGIIDASIDGQLQALKQAITKQLSERQQIQT Kraken2_NZ_CP061864.1 IMICODJL_11508 Prodigal:2.6 1 1065 + VFG044426(gb|CAJ45633) 60.7 1.6300000000000002e-129 (dahP) DAHP synthetase VF1246 Vanchrobactin VFC0272 Nutritional/Metabolic factor MLSRIFHATSFTSLPSFKETHSDSPLGDKQRFFVEQQRKQIKRILLGQDPRLLVIIGPCSIHDPIAALDYARKLAAIQHEFADTLKIVMRTYFEKPRTRFGWKGFGIDPDLNGQHNIAKGITLTRQLLNSILELHVPTATEFLDPNFAPYLADMICWGAIGARTTESQPHRQLVSALHCAVGFKNSTNGNIDHAIDAIHASRMPQSLIQSNSEGCHVVIHSPGNQYGHLILRGGDSPNYTQPHVQAAAFALKRNDLAAKLIVDFSHGNSQKTAHNQLNVASDIAAQIQAGDDKIVGIMCESFLQGGQQPSDQRPLNYGQSITDECLGWQDSVDLLRILHRACIEKCKRHRPIIA Kraken2_NZ_CP061864.1 IMICODJL_11518 Prodigal:2.6 28420 30018 + VFG044187(gb|WP_011152546) 60.4 8.92e-221 (BJE04_RS21785) AMP-binding protein VF0626 Vibriobactin/Vulnibactin VFC0272 Nutritional/Metabolic factor MTSLGETAQVSPDLKQQYAQAGLWENVPLWHLLWCHLPKFENRIAVRDDKESLSYNELMTQADQVATRLLSQGWTSGDHIVMQLSNSCQFAVTLFGLLRAGIIPVMALPAHGLAEIEHFMRISSAKGYIGEGLSGQQMVDALQKQPDLKLYLVDQITQPYALPCVPIQTFNPTIVNPETPALFLVSGGTTGLPKLIPRTHNDYLYNIRCCCNASEVTEEEIYLVVLPAAHNFPLGCPGFLGTLSLGGEVIFTQLASPDHCFELIEQFGVTATALVPALAQLWTEATQWEETNLTSLKRIQVGGSKLAYSNAIEMQTAFPSALQQVFGMAEGLIACTRLTDPPEVIASMQGKPVSSWDEIRIVDNDGNDVALGEEGELLTRGPYTLSGYYRAPEHNARSFTEEGYYCTGDKVRINAERYLTVTGRIKDIINRAGECIAADEIEEQLLAHPNVTQVAVVAVPDPHLGERIGVAVVGRGAAITLQDLRQFLIGQNLATFKLPDELILVSRLPKTAVGKIDKKAILGPSGTPWHKG Kraken2_NZ_CP061864.1 IMICODJL_11528 Prodigal:2.6 40529 41254 - VFG002301(gb|NP_490536) 65.1 7.02e-100 (mig-5) putative carbonic anhydrase VF0396 Mig-5 Macrophage-inducible gene-5 VFC0325 Antimicrobial activity/Competitive advantage Mig-5 was found to be expressed by Salmonella when ingested by macrophages. mig-5 codes for the carbonic anhydrase which catalyses the hydratation of carbon dioxide and formation of HCO3-. The biological meaning of this reaction in intracellularilly residing of Salmonella is, however, not known. MCTDNCGMDLSKRKLLKYSTGIAALSIVGSTLSITYAASLTKEERDNMSPNDVVNSLIDGNKRFISNKPLNHDYRAQKKSSQHGQYPSAVILSCIDSRAPAEIILDTGIGELFNSRVAGNISNDDILGSMEFACAAAGAKVVFVMGHTKCGAVKGAIANVELGNLTGLLDKIKPAIKKTTFAGDRTAENYDFVDAVAKTNVLLVINDIRENSATLKKLEDEGKIKIVGAMYDISNGKVSLI Kraken2_NC_017508.1 IMICODJL_12611 Prodigal:2.6 17183 19090 + VFG045768(gb|WP_012979416) 64.6 5.1199999999999997e-290 (lvhD4) type IV secretory system conjugative DNA transfer family protein VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MKPKINNAVGPQVRDRKPKKQRLLPALGAVSVLGGLQAATQFFAYTFNYQDNLGGHINHVYAPWSILSWASDWYSIYPDEFMRSGSIGMVVTTVGLLGVAIAKVVTSNSSKASEYLHGSARWAEKKDIQAAGLLPRERTALEVVTGKDAPTSTGVYVGGWEDKDGNFFYLRHNGPEHVLTYAPTRSGKGVGLVVPTLLSWPQSSVITDLKGELWALTAGWRQKHAKNKVLRFEPASSNGGVCWNPLDEIRIGTEYEVGDVQNLATLIVDPDGKGMDSHWQKTSYALLVGVILHALYKSKNEGTPATLPVVDAMLADPERDTGELWMEMATYGHVDGQNHPAVGSAARDMMDRPEEEGGSVLSTAKSYLALYRDPVVARNVSKSEFRIKDLMNHDDPVSLYIVTQPNDKARLRPLVRVLTNMIIRLLADEMSFEKGRPVAHYKHRLLAMLDEFPSLGKLEILQESLAFVAGYGIKCYLICQDLNQLKSRETGYGPDETITSNCHVQNAYPPNRIETAEHLSRLTGQTTVVKEQITTSGRRTSAMLGQVSRTIQEVQRPLLTPDECLRMPGPTKNAAGDIEKAGDMVIYVAGYPAVYGKQPLYFKDPVFQARASVDAPKISDKLRIVAEPEGEGVTI Kraken2_NC_017508.1 IMICODJL_12637 Prodigal:2.6 38068 40608 - VFG045766(gb|WP_012979408) 67.1 0.0 (lvhB4) conjugal transfer protein TrbE VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MMIQAISFAIAVCGAALLLILFARIRAVDAELKLKKHRSKDAGLADLLNYAAVVDDGVIVCKNGAFMASWLYKGDDNASSTDEQREMVSFRINQALAGLGNGWMVHVDAVRRPAPNYSERNTSAFPDPVSAAIDEERRQLFEGLGAMYEGYFVLTLTWFPPLLAQRKFVELMFDDDAEVVGKKARTKGLINQFKREISGIENRLTTAVKLTRLRGQKIVNEDGSKVTHDDFLSWLQFCVTGVSHPVQLPNNPMYMDAYIGGQEMWGGVVPKVGRKFIQVVSIEGFPLESHPGILSALAELPVEYRWSSRFIFMDQHESIKHLDKFRKKWKQKVRGFFDQVFNTNSGNVDQDALTMVQDAESAIAEVNSGLVAVGYYTSVVVLMDESRDRLEQSARQVEKSINRLGFAARTETINTLDAYLGSLPGHGVENVRRPLINTMNLADLLPTSTIWTGNADAPCPMYPPLSPALMHCVTSGSTPFRLNLHVRDLGHTFMFGPTGAGKSTHLALIAAQLRRYAGMSIFAFDKGMSMYPLTKAVGGLHFSVGADDDHLSFCPLQYLETKSDRAWAMEWIDTILALNGVQSTPAQRNEIAHAIVSMHESGARTLSEFSLTIQDESIREAIRQYTVDGSMGHLLDADEDGLSLTDFTTFEIEELMNLGEKFALPVLLYLFRRIERSLKGQPAVIILDEAWLMLGHPAFREKIREWLKVLRKANCLVLMATQSLSDAANSGILDVIVESTATKIFLPNVYARDEDTSALYRRMGLNARQIDILATAVPKRQYYYVSENGRRLYDLALGPLALSFVGASDKESVAAIKQLEAKYGEQWVHEWLAGRGLKLDNYLEAA Kraken2_NC_017508.1 IMICODJL_12640 Prodigal:2.6 41370 42329 - VFG045767(gb|WP_012979404) 73.2 1.6800000000000002e-164 (lvhB11) P-type conjugative transfer ATPase TrbB VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MQQNDMTGSIKDRAKRKLERDIGPELLQALNHSKTVELMLNADGKVWVERLGEGMQCIGTLRPAQAQAIIETIAGYHGKEVTRSKPILEGEFPLDGSRFAGQLPPVVPAPTFAIRKKAVAIFTLDQYVENGIMTAAQKHVLVEAVAAHRNILVIGGTGSGKTTLVNAIINEMVITDPTERVFIIEDTGEIQCAAENHVQYHTSLDVSMTALLKTTLRMRPDRILVGEVRGAEALDLLDAWNTGHEGGAATLHANNANAGLARLRSLITRNPAAPAEIEPLIGEVVHIVVHIARTPEGRRIQEILEVSGYCDGQYITKSL Kraken2_NC_017507.1 IMICODJL_12682 Prodigal:2.6 41132 42205 + VFG037923(gb|WP_000699387) 74.1 5.81e-201 (rfbB) dTDP-glucose 4,6-dehydratase VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MKLLITGGAGFIGSAVIRHIINGTTDEVVNLDILTYAGNLESLKEVNDSSRYTFEQVDICDRSGVDRVLAEHQPDAIMHLAAESHVDRSIDGPADFIETNIVGTYTLLEATRQYWQGLEAEKKANFRFHHISTDEVYGDLPHPSETSNAEEHLFTEQTAYAPSSPYSASKASSDHLVRAWQRTYGLPVLVTNCSNNYGPYHFPEKLIPLIILNALEGKPLPVYGKGDQIRDWLYVEDHARALYKVVTEGQPGKTYNIGGHNEKQNIDVVHIICGILQELRPQERSYGELITFVRDRPGHDRRYAIDADKIQRELGWAPEETFETGIRKTVQWYLDNLDWCQRVQEGSYQRERLGAAS Kraken2_NC_017507.1 IMICODJL_12684 Prodigal:2.6 43135 44019 + VFG037938(gb|WP_000104825) 73.0 1.9e-154 (rfbA) glucose-1-phosphate thymidylyltransferase RfbA VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MKGIILAGGSGTRLYPITRGISKQLLPVYDKPMIYYPLSVLMLAGIRDILVITTPEDQQGFQRLLGDGSQWGINLSYAEQPSPDGLAQAFIIGDDFIGDDSVCLVLGDNIYYGQGLSNMLQAAAKRGKGATVFGYQVTDPERFGVVEFDDNHRAISIEEKPANPKSDYAVTGLYFYDNDVVEIAKQVEPSHRGELEITSVNQAYLERGDLNVELLGRGFAWLDTGTFDSLHDAAGFIETLEKRQGLKIACLEEVAYRMGFIGEEELLAGAENLKKNSYGDYLKKLVKQPSKPTL Kraken2_NC_017507.1 IMICODJL_12698 Prodigal:2.6 58756 59787 + VFG038016(gb|WP_001083066) 79.8 1.02e-199 (ABBFA_RS17165) Vi polysaccharide biosynthesis UDP-N-acetylglucosaminuronic acid C-4 epimerase TviC VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MLSADNRRYPQLLDQLPSQPKTWLITGAAGFIGSNLLEHLLKLNQHVIALDNFATGHQSNLDEVRSLVSTEQWTRLQSIEGDIRNPEDCARACEGVDYVLHQAALGSVPRSLNDPITTNAANITGFLNMLVAARDAGVKSFTYAASSSTYGDHPALPKVEEKIGKPLSPYAVTKHVNELYAEVFARSYGFKAIGLRYFNVFGKRQDPNGAYAAVIPKWTAAMVRGEDVFINGDGETSRDFCFIENAVQANLLAATAEDSARNEVYNVAVGDRTTLNDLFAALKSALAENGVVYDKAPVYRDFRPGDVRHSQADIGKASSRLGYNPEFRIVEGIAKAMPWYLKH Kraken2_NC_017507.1 IMICODJL_12700 Prodigal:2.6 61007 62269 + VFG019781(gb|WP_012613866) 69.9 6.71e-210 (tviB) Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB VF0085 LPS VFC0258 Immune modulation Two distinct forms of LPS: A-band and B-band. A-band is a homopolymer of alpha-linked D-rhamnose, whereas B-band LPS is a heteropolymer Mediates biological effects including resistance to serum killing and phagocytosis; the binding to normal CFTR (cystic fibrosis transmembrane conductance regulator) and invasion of host cells may make a contribution to virulence in the human eye; internalization by binding to normal CFTR protein expressed by airway epithelial cells followed by desquamation of bacteria-laden epithelial cells, constitutes a host defense mechanism. If this mechanism fails to function properly, abnormally high bacterial carriage would promote the establishment of chronic bacterial infection Binding interaction occurs between the first extracellular loop of CFTR (predicted to be in amino acids 108-117 of the mature protein) and the complete outer portion of the core polysaccharide of the LPS MRNIAVIGLGYVGLPLAVAFGEKRPVVGFDINAKRIGELQRGHDVTREVSSEELANASHLRCTDSLDDLKDCTVFIVTVPTPIDEFKTPDLTPLIKASETVGVVLKPGDIVIYESTVYPGATEEVCVPVLERLSGLKFNEDFYAGYSPERINPGDKEHRVTTIMKVTSGSTPAIAAEVDALYADIITAGTHKASSIKVAEAAKVIENTQRDLNIALMNELSMIFNRLGIDTHEVLAAAGTKWNFLPFKPGLVGGHCIGVDPYYLTHKAQAIGYHPEIILAGRRVNDGMGPYAAAELVKAMIKRGVTIADSRVLVMGLTFKENCPDLRNTRVVDVIDELRDYGCVVDVTDCWADPVEAKHEYGLKLVAEPQQGFYDAVLLAVPHNDYAAMSAADLRGFAKQGAVLFDLKGALPLGEADLRL Kraken2_NZ_CP109970.1 IMICODJL_13272 Prodigal:2.6 7891 10257 + VFG018691(gb|WP_012232117) 62.2 0.0 (virB4) type IV secretion system virB4 protein homolog VF0369 VirB/VirD4 type IV secretion system VFC0086 Effector delivery system The VirB/VirD4 T4SS is well conserved within the genus Bartonella, although it is absent in B. bacilliformis. Its closest relative is a genuine conjugation system, the AvhB/TraG system of the cryptic plasmid pATC58 of Agrobacterium tumefaciens; The Bartonella VirB/VirD4 system is encoded by an operon of 10 genes (virB2-virB11). Seven Bartonella-translocated effector proteins (BepA-BepG) and the coupling protein VirD4 are encoded within 22 kb downstream of the virB operon. The entire virB/virD4/bep region probably constitutes a pathogenicity island The Bartonella VirB/VirD4 system is considered to encompass a VirB2 pilin and VirB5 minor pilus component, which form a pilus that can mediate contact with host cells. The components VirB3, VirB4 and VirB6-VirB11, which form a pore complex that spans both Gram-negative membranes and possibly also the host-cell membrane. And the T4SS coupling protein (T4CP) VirD4, an inner-membrane protein thought to function as an interface between the pore complex and the T4SS substrates Crucial for establishment of infection in the primary niche- the endothelial cells, required for colonization of endothelial cells, by mediating the intracellular delivery of effector proteins (BepA-BepG). Translocation of the Beps provokes distinct cellular phenotypes: (i) a massive cytoskeleton rearrangement, resulting in the engulfment of bacterial aggregates (a phenotype called 'invasome' formation), (ii) NF-kappaB-dependent proinflammatory activation, characterized by chemokine secretion and expression of cell adhesion proteins, and (iii) enhanced cell survival as a result of anti-apoptosis (iv) capillary-like sprout formation of endothelial cell aggregates The Bartonella-translocated effector protein (BepA-BepG) are required for invasion, proinflammatory activation and anti-apoptotic protection of endothelial cells. The C terminus of each Bep harbours at least one copy of the novel Bep intracellular delivery (BID) domain and a short, positively charged tail sequence. The bipartite C terminus is required for protein transfer, their N-terminal region might be crucial for effector function within host cells.; The N termini of BepA-BepC comprise the Fic (filamentation induced by cAMP) domain, which is conserved in many bacteria and was proposed to be involved in bacterial cell division. The effector functions of the Fic domain within mammalian target cells are unknown.; The N termini of BepD-BepF contain short repeated peptide sequences that contain conserved putative tyrosine-phosphorylation motifs (EPLYA). Future studies might show how tyrosine-phosphorylated Beps contribute to the subversion of endothelial-cell function. BepG is unique among the Beps because it appears to be entirely composed of BID domains.; Invasome formation can be triggered in a redundant manner, either by BepG alone or by the combined action of effectors BepC and BepF. MLRTRELSPEAFIPYVRHIDETTIALDSRSMMVMIALEGVSFETADVLDLNALHRDINTLYRNIVDERLALWTHMIRRRDSDYPDGTFATPFSAALNDKYRQRMVGEDLFRNDLYLSVLWSPARDPADKAAKLLSRLRRARHGGFELDEEALKQLRDKVLDVTAGLKRFEPRVLSLYEQDGMLFSEPSEVLHQIVGGRRERVPLTEGSIASAIYSDRVIIGRETIEIRHEAATRFAGILSFKEYPARTRTGMLDGVLTSPFELMLSQSFSFVSKADARVIMGRKQNQMVSSGDKAASQIDELDDAMDDLESNRFAIGEHHLTLSVFASTVKELTDNLAKARASLTNGGAVVAREDLGLEAAWWAQLPGNFRYRARSGAITSKNFAALSPFHSYPIGQKDGNEWGPAVALLKTASGSPYYLNLHYGDLGNTFMCGPSGAGKTVIVNFMLSQLEKHDPHVVFFDKDRGADLYVRAAGGTYLPLKNGVPTGCAPLKALDLTPENKVFLARWVGKLVGSGTRELTVTELRDIAGAIDGLADLPVDRRTIGALRTFLNNTDPEGIAARLRRWERGGPLGWVFDNVIEDIGFGDFGGSGKFIGYDMTDFLDNEEIRTPLMAYLFHRVEQLIDGRRIIIVIDEFWKALQDEGFRDLAQNKLKTIRKQNGLMLFATQSPRDALISPIAHTIIEQCPTQIFLPNSRGSHADYVDGFKLTEREYELVARELSVESRRFVLKQGHNSVVAELDLNGFDEELAILSGRTANVELLDAIRAEVGNDVKDWLPIFQQRRSAS Kraken2_NZ_CP109970.1 IMICODJL_13278 Prodigal:2.6 13097 13948 + VFG018745(gb|WP_012232413) 64.8 3.44e-122 (vbhB9) P-type conjugative transfer protein VirB9 VF0680 VirB-homolog (vbh) type IV secretion system VFC0086 Effector delivery system MMRTVPIVAFVLSVSMSSALALEIPRGASQDSRVRFVNYQPYNITRVVGTLRSSVQVEFASDEEIAHVALGNSVAWEVAPAGNILFLKPRENQPVTNISVVTTRRDGSTRSYQMELTVRDGSVEAGQNTYFYVKFRYPEDEAAFRRQQAASRALAAQAKDADNVLTLHEAYGPRNWRYSAQGSQALEPQSVYDNGKITTFAFVGNQEMPAIYMENSDGSESLVPKSVDGNLVMVHAISRKFILRRGKDVLCVFNEAYDRVGINPDTNTTSPSVERVVKSDNAQ Kraken2_NZ_CP109972.1 IMICODJL_13838 Prodigal:2.6 154579 155517 + VFG041352(gb|WP_010891511) 100.0 1.16e-220 (ATU_RS23750) hypothetical protein VF1257 VirB/VirD system VFC0086 Effector delivery system MEPSQRSLSDESEASRTEVHSTSTNRDMPPELLAKVATYIPTQDPVETARNLGSLERTGRAGREAVTSDPVGKYHARMKRIGASAKTVFDTVIPGNQLPEWETNRPSPTARTRAVGPILKFQSEAGKSRFVTNILNLPESAQCDAILSVIKHLNDLGEANKTRLIERSIEILRLEPPLTWNMGQKCPAVDVLVQGEKYLNADQLARIQQERSSRPRLSPLFGRAIADFEVQKTMDANPRRYRDAAGPEVRAVDTVIETIERYSASLARGGPNAVGLLTTNESFEKNINEVYNRTRAELDASSRDRSRSGLSR Kraken2_NZ_CP109972.1 IMICODJL_13850 Prodigal:2.6 165966 166703 + VFG041353(gb|WP_010974915) 99.6 8.95e-155 (ATU_RS23790) type IV secretion system lytic transglycosylase VirB1 VF1257 VirB/VirD system VFC0086 Effector delivery system MLKATGPLSIILLASTCPSSGAAPLSFAEFNNFARECAPSVAPSTLAAIAQVESRFDPLAVHDNTTGETLHWQNQAQATQVVMDRLEARHSLDVGLMQINSRNFSVLGLTPDGALQPCTSLSVAANLLGSRYAGGNTADDEQLSLRRAISAYNTGDFTHGFANGYVRKVETAAQQLVPSLTARPKDDREKPGSEETWDVWGAYKRRSPEGGAGGSSGPPPPPDEDNRKSEDDDQLLFDLNQGGPQ Kraken2_NZ_CP109972.1 IMICODJL_13851 Prodigal:2.6 166703 167068 + VFG041354(gb|WP_010891502) 100.0 5.98e-79 (virB2) pilin major subunit VirB2 VF1257 VirB/VirD system VFC0086 Effector delivery system MRCFERYRVHLNRLSLSNAVMRMVSGYAPSVVGAMGWSIFSSGPAAAQSAGGGTDPATMVNNICTFILGPFGQSLAVLGIVAIGISWMFGRASLGLVAGVVGGIVIMFGASFLGKTLTGGG Kraken2_NZ_CP109972.1 IMICODJL_13852 Prodigal:2.6 167068 167394 + VFG041355(gb|WP_010891501) 100.0 8.000000000000001e-71 (ATU_RS23800) type IV secretion system protein VirB3 VF1257 VirB/VirD system VFC0086 Effector delivery system MNDRLEEATLYLAATRPALFLGVPLTLAGLLVMFAGFVIVIVQNPLYEVVLVPLWFGARLVVERDYNAASVVLLFLQTAGRSVDGLIWGGASVSPNPIKVPARGRGMA Kraken2_NZ_CP109972.1 IMICODJL_13853 Prodigal:2.6 167394 169763 + VFG041356(gb|WP_010974916) 99.1 0.0 (virB4) type IV secretion/conjugal transfer ATPase VirB4 VF1257 VirB/VirD system VFC0086 Effector delivery system MLGASGTTERSGEVYLPYVGHLSDQIVLLEDGSIMTMAHVSGMAFELEDAEMRNARCRAFNTLLRNIADDHVSIYAHLVRHDDVPPSPARHFRSAFSASLSEAFEERVLSGKLLRNDHFLTLIVSPRAALGKVRRRFTKRYRQKENDLTDQTRNLEDLWHLVAGALEAYGLRRLGIREKQDVLFTEVGEALRLIMTGRFTPVPVVSGSLGASIYTDRVICGKRGLEIRTPKDSYVGSIYSFREYPATTRPGMLNVLLSLDFPLVLTQSFSFLTRSQAHSKLSLKSSQMLSSGDKAVTQISRLSEAEDALASNEFVMGAHHLSLCIYANDLNSLADRGARARTRLADAGAVVVQEGIGMEAAYWSQLPGNYKWRTRPGAITSRNFAGLVSFENFPEGSGSGHWGNAIARFRTNGGTPFDYIPHEHDVGMTAIFGPIGRGKTTLMTFILAMLEQSMVDRAGAVVLFDKDRGSELLVRATGGTYLALRRGAPSGLAPLRGLENTAASHDFLREWIVALIESDGRGGISPEENRRLVRGIHRQLSFDPHMRSIAGLREFLLHGPAEGAGARLQRWCRGNALGWAFDGELDEVKLDPSITGFDMTHLLEYEEVCAAAAAYLLHRIGAMVDGRRFVMSCDEFRAYLLNPKFAAVVDKFLLTVRKNNGMLILATQQPEHVLESQLGASLVAQCMTKIFYPSPTADRSAYIDGLKCTEKEFQAIREDMAVGSRKFLLKRESGSVVCEFDLREMREYVAVLSGRANTVRFADQLRKVQGDNPSAWLSEFMARYHEAKD Kraken2_NZ_CP109972.1 IMICODJL_13854 Prodigal:2.6 169780 170442 + VFG041357(gb|WP_010891499) 100.0 4.68e-140 (virB5) pilin minor subunit VirB5 VF1257 VirB/VirD system VFC0086 Effector delivery system MKIMQLVAAAMAVSLLSVGPARAQFVVSDPATEAETLATALETAANLEQTITMVAMLTSAYGVTGLLTSLNQKNQYPSTRDLDTEMFSPRMPMSTTARAITTDTDRAVVGGDAEADLLRSQITGSANSAGIAADNLETMDKRLTANAETSTQLSRSRNIMQATVTNGLLLKQIHDAMIQNVQATSLLTMTTAQAGLHEAEEAAAQRKEHQKTAVIFGAVP Kraken2_NZ_CP109972.1 IMICODJL_13855 Prodigal:2.6 170543 171430 + VFG041358(gb|WP_010974917) 99.7 3.5e-202 (ATU_RS23815) type IV secretion system protein VF1257 VirB/VirD system VFC0086 Effector delivery system MNFTIPAPFTAIHTIFDLAFTTSLDTMLGTIQEAVSAPLVACVTLWIIVQGILVMRGEIDTRGGITRVITVTVVVALVVGQANYHDYVVSVFEETIPNFIQQFSGSGLPLQTIPAQLDTMFALTQAAFQRIASEIGPMNDQDILAFQGAQWVFYGTLWSAFGIYDAVGILTKVLLAIGPLILTGYIFDRTRDIAAKWIGQLITYGLLLLLLNLVATIVILTEATALTLMLGVITLAGTTAAKIIGLYELDMFFLTGDALIVALPAIAGNIGGSYWSGATQSANSLYRRFAQVERR Kraken2_NZ_CP109972.1 IMICODJL_13856 Prodigal:2.6 171465 171632 + VFG041359(gb|WP_010891497) 100.0 1.19e-39 (ATU_RS23820) type IV secretion system lipoprotein VirB7 VF1257 VirB/VirD system VFC0086 Effector delivery system MKYCLLCLALALGGCQTNDKLASCKGPIFPLNVGRWQPTPSDLQLSNVGGRHEGV Kraken2_NZ_CP109972.1 IMICODJL_13857 Prodigal:2.6 171619 172332 + VFG041360(gb|WP_010891496) 100.0 2.9799999999999998e-165 (ATU_RS23825) type IV secretion system protein VirB8 VF1257 VirB/VirD system VFC0086 Effector delivery system MKGSEYALLVARETLAEHYKEVEAFQTARAKSARRLSKVIAAVATIAVLGNVAQAFTIATMVPLIRLVPVYLWIRPDGTVDSEVSVSRLPATQEEAVVNASLWEYVRLRESYDADTAQYAYDLVSNFSAPMVRQNYQQFFNYPNPTSPQVILGKHGRLEVEHIASNDVTPGVQQIRYKRTLIVDGKMPMASTWTATVRYEKVTSLPGRLRLTNPGGLVVTSYQTSEDTVSNAGHSEP Kraken2_NZ_CP109972.1 IMICODJL_13858 Prodigal:2.6 172329 173210 + VFG041361(gb|WP_010891495) 100.0 1.7600000000000003e-210 (virB9) P-type conjugative transfer protein VirB9 VF1257 VirB/VirD system VFC0086 Effector delivery system MTKKAFLTLACLLFAAIGARAEDTPTAGRLDPRMRYLAYNPDQVVRLSTAVGATLVVTFGANETVTAVAVSNSKDLAALPRGNYLFFKASKVLPPQPVVVLTASDAGMRRYVFSISSKTLPHLDKEQADLYYSVQFAYPADDAAARQKAAQEKAVADRIRAEAQYQQRAEGLLEQPATTVGAEDKNWHYVAQGDRSLLPLEVFDDGFTTVFHFPGNVRIPSIYTINPDGKEAVANYSVKGSYVEISSVSRGWRLRDGHTVLCIWNTAYDPVGRRPETGTVRPDVKRVLKEVRG Kraken2_NZ_CP109972.1 IMICODJL_13859 Prodigal:2.6 173207 174340 + VFG041362(gb|WP_010891494) 99.5 5.49e-270 (virB10) type IV secretion system protein VirB10 VF1257 VirB/VirD system VFC0086 Effector delivery system MNDDNQQSAHDVDASGSLVSDTHHRRLSGAQKLIVGGVVLALSLSLIWLGGREKKENGDAPPSTMIATNTKPFHPAPIDVTLDPPAAQEAVQPTAPPPARSEPERHEPRPEETPIFAYTSGDQGTSKRVQQGETDRRREGNGEDSPLPKVEVSAENDLSIRMKPTELQPTRATLLPHPDFMVTEGTIIPCILQTAIDTSLAGYVKCVLPWDVRGTTNNVVLLDRGTTVVGEIQRGLQQGDTRVFVLWDRAETPDHAMISLASPSADELGRSGLPGTVDNHFWQRFSGTMLLSVVQGAFQAASTYAGSSGGGTSFNSVQNNGEQTADTALKATINIPPTLKKNQGDTVSIFVARDLDFSGIYQLRMAGRAARGRDRRP Kraken2_NZ_CP109972.1 IMICODJL_13860 Prodigal:2.6 174381 175415 + VFG041363(gb|WP_010974918) 97.4 1.8999999999999997e-242 (virB11) P-type DNA transfer ATPase VirB11 VF1257 VirB/VirD system VFC0086 Effector delivery system MEVDPQLRILLKPILEWLDDPRTEEVAINRPGEAFVRQAGAFLKFPLPVSYDDLEDIAILAGALRKQDVGPRNPLCATELPDGERLQICLPPTVPSGTVSLTIRRPSSRVSSLKEVSSRYDAPRWNQWKGRKKRHDQHDEAILRYYDNGDLEAFLHACVVGRLTMLLCGPTGSGKTTMSKTLINAIPPQERLITIEDTLELVIPHENHVRLLYSKNGAGLGAVTAEHLLQASLRMRPDRILLGEIRDDAAWAYLSEVVSGHPGSISTIHGANPVQGFKKLFSLVKSSAQGASLEDRTLIDMLATAVDVIVPFRAHGDIYEVGEIWLAADARRRGETIGDLLNQQ Kraken2_NZ_CP109972.1 IMICODJL_13865 Prodigal:2.6 178591 179934 + VFG041364(gb|WP_010974919) 99.6 6.75e-311 (ATU_RS23865) T-DNA border endonuclease VirD2 VF1257 VirB/VirD system VFC0086 Effector delivery system MPDRAQVIIRIVPGGGTKTLQQIINQLEYLSRKGRLELQRSARHLDIPLPPDQIHELARSWVQETGTYDESQPDEERQQELTTHIIVSFPAGTSQVAAYAASREWAAEMFGSGAGGGRYNYLTAFHIDRDHPHLHVVVNRRELLGHGWLKISRRHPQLNYDALRIKMAEISLRHGIALDASRRAERGITERPITYAQYRRLEREQARQIRFEDADLEQSSPQGDHPEFSQPFDTSPFEASAGGPEDMPRPNNRQNESQVHLQEPAGVSNEAGVLVRVALETERLAQPFVSETILADDIGSGSSRVAEGRVESANRTPDIPRAATGAATHTTHDRQRRAKRPHDDDGGPSGAKRVTLEGIAVGPQANAGEQDGSSGPLVRQAGTSRPSPPTATTRASTATDSLSATAHLQQRRGVSSKRPREDDDGEPSERKRERDERSKDGRGGNRR Kraken2_NZ_CP109972.1 IMICODJL_13867 Prodigal:2.6 181951 184050 + VFG041365(gb|WP_010974920) 99.4 0.0 (virD4) type IV secretion system ATPase VirD4 VF1257 VirB/VirD system VFC0086 Effector delivery system MKVTGGKGCVVRSNTQIKSPICDRSKNLGEVMNSSKTTPQRLAVSIVCSLAAGFCAASLYVTFRHGFNGEAMMTFSVFAFWYETPLYMGHATPVFYCGLAIVVSTSIVALLSQLIISFRNHEHHGTARWAGFGEMRHAGYLQRYNRIKGPIFGKTCGPRWFGSYLTNGEQPHSLVVAPTRAGKGVGVVIPTLLTFKGSVIALDVKGELFELTSRARKAGGDAVFKFSPLDPERRTHCYNPVLDIAALPLERQFTETRRLAANLITAKGKGAEGFIDGARDLFVAGILTCIERGTPTIGAVYDLFAQPGEKYKLFAHLAEESRNKEAQRIFDNMAGNDTKILTSYTSVLGDGGLNLWADPLVKAATSRSDFSVYDLRRKRTCVYLCVSPNDLEVVAPLMRLLFQQVVSILQRSLPGKDERHEVLFLLDEFKHLGKLEAIETAITTIAGYKGRFMFIIQSLSALTGTYDDAGKQNFLSNTGVQVFMATADDETPTYISKAIGDYTFKARSTSYSQARMFDHNIQISDQGAPLLRPEQVRLLDDNNEIVLIKGHPPLKLRKVRYYSDRMLRRLFECQIGALPEPASLMLSEGVHRDGQDLSQHAAVTEAQGLGDIDSIPNNMEAATPQNSEMDDEQDSLPTGIDVPQGLIESDEVKEDAGGVVPDFGVSAEMAPAMIAQQQLLEQIIALQQRYGPASSHSVK Kraken2_NZ_CP109972.1 IMICODJL_13868 Prodigal:2.6 184162 186687 + VFG041366(gb|WP_010974921) 98.8 0.0 (ATU_RS23880) virA/G regulated protein VF1257 VirB/VirD system VFC0086 Effector delivery system MRPSGNPNVDLSGSTASLAEVPAGATPVLNLIEPRNRPADDSLEGQTDRGEHPSASFDYDGMKLGAAEREAYENWCPSNRPTWKDLVLRARLDAIDSSAWLPDLGEESPLIFRYEGIPLGEGERQAYKEWQEDAQPTWEDLVVNARMAEPDPCADIADEHNPLKEGEEFRSEASKRKRKKPIDQDENSSTSFYHDGMRLGEPEREAYDNWGNAEPPTWKDLVLKARLDAIDSSAWLFASEGSSSTFEYEGIPLGEGERQAYKEWQEDAQPTWEDLVVNARMAELDHSSWITDEHNSLEENLEFGPDARQASLKDSTDQRKSSSASFIYDGMKLGEPEHAAYENWSKPERPSWEALILDARQASIASSSVSNSLLAKTSSPVFLYEGMSLGDAERQAYGRWRQPAQPRWQNLVVNARLADLDPLAWIPDEHDPFAEAEALSPTSQSSGANKSNRALGNQSDSGRPAFAYLAAQEASHLQSPACSQLETRRALNFGSPGPDANPTESIAKCNRLDGVSKIKRLGTKGRRAVNATIHGGKFGAQGLLSEDCGQAAEPSPSEQTTRPRTDNIGTYASRKNERARLATETGKYESEHIFGFKVVHDTLRATKEGRRLERPMPAYLEYKELHRQHVGTGRGRTGLVGRGWPDDASYRADQRATLSDPVASAEGATASNGYQLNQLGYAHQLATHGLQSETPDGVTMPIQVATISYNYTVSRDPVLSPPSKEQAPPLLHLGPRGQTEAVLARETALTGKWPTLERECQVYQRFLALYDVKKDLDAKQLGVRQKKQALVAALNRTAGLIGASPLEAQSSTAEVEYTTDEPDERRVYDPRDRGRDKAFNR Kraken2_NZ_CP109972.1 IMICODJL_13871 Prodigal:2.6 188422 190092 + VFG041367(gb|WP_010974922) 99.8 0.0 (ATU_RS23900) type IV secretion system single-stranded DNA binding effector VirE2 VF1257 VirB/VirD system VFC0086 Effector delivery system MDPKAEGNGENITETAAGNVETSDFVNLKRQKREGVNSTGMSEIDMTGSQETPEHNMHGSPTHTDDLGPRLDADMLDSQSSHVSSSAQGNRSEVENELSNLFAKMALPGHDRRTDEYILVRQTGQDKFAGTTKGNLDHLPTKAEFNASCRLYRDGVGNYYPPPLAFERIDIPEQLAAQLHNLEPREQSKQCFQYKLEVWNRAHAEMGITGTDIFYQTDKNIKLDRNYKLRPEDRYIQTEKYGRREIQKRYEHQFQAGSLLPDILIKTPQNDIHFSYRFAGDAYANKRFEEFERAIKTKYGSDTEIKLKSKSGIMHDSKYLESWERGSADIRFAEFAGENRAHNKQFPAATVNMGRQPDGQGGMTRDRHVSVDYLLQNLPNSPWTQALKEGKLWDRVQVLARDGNRYMSPSRLEYSDPEHFTQLMDQVGLPVSMGRQSHANSVKFEQFDRQAAVIVADGPNLREVPDLSPEKLQQLSQKDVLIADRNEKGQRTGTYTNVVEYERLMMKLPSDAAQLLAEPSDRYSRAFVRPEPALPPISDSRRTYESRPRGPTVNSL Kraken2_NZ_CP109972.1 IMICODJL_13872 Prodigal:2.6 190159 192213 + VFG041368(gb|WP_010974923) 99.1 0.0 (ATU_RS23905) virA/G regulated protein VF1257 VirB/VirD system VFC0086 Effector delivery system MVDTTKKSVAKSLTADMRRSAKRLSKQMRKTSLTEEEATRNLARLETPDQKRKYVADMQIIDKLEDGFRGEISYKMLGNKQLRVDSPKELTREHGIIRKTRKVLKRNAETGNVYLGLHEKKTWRSVSSHLYAEDGTLRAKHVKYKDGRFEEKWERDENGLLFRTQFVNRNRLFQPISEKVSTPYRSGPENRLFRELTRRKGSKQETFERDEKGNLELIGSKRLGFSKNSTKAVDRQTSQTTIRKLGGAFSKSYRSLLDTEGNELGRDISSHRRLFNKRSAVYDEASGQLTSTKHTFGKIYKSETAYLNADIKKVSKKILGVTVRRKLTTLSEQEHDAQKLRNSESIEHRKAWQERAVIPRSPPRETANVDSAPQSHLVNSLRDGRRDEAEPRVVPAKDRRFDGVIQNSPLFRQPNSERRVGSQTLPPSSNVRALDPVFPREGAKSEKGPVAVNLQRDNEREKQEEKNLSERRGNLFRSSRSITEMSFPGSPERITMLGSRRASINPSADPQSPVGRTDSQAPPMSLFPINNHQSDPNEQELLSFLHSVPVPPPLEVHGAPGGRVEDSLRGASGDSLVRTSSVSESVFDEHSQGPLERDHSTNATSERFDPQALFGEPGLSRVSETRPELSMQGDHLTNSEQQALLNELLSVPLPGPLPKADHERPRVLESSRSRERSISGGLSL Kraken2_NC_019985.2 IMICODJL_14290 Prodigal:2.6 12808 14448 + VFG045692(gb|WP_197532029) 74.5 3.8400000000000004e-271 (htpB) Hsp60, 60K heat shock protein HtpB VF0159 Hsp60 VFC0001 Adherence Mediate a complement-independent attachment to mammalian and amoebal host cells Specific receptors have not been identified MAAKDIRFGEDARSKMVRGVNVLANAVKATLGPKGRNVVLQKSYGAPTITKDGVSVAKEIELADAFENMGAQMVKEVASKTSDNAGDGTTTATVLAQAFIREGMKAVAAGMNPMDLKRGIDQAVKAAVGELKSLSKPSSTSKEIAQVGAISANSDANIGDLIAQAMDKVGKEGVITVEEGSGLDNELDVVEGMQFDRGYLSPYFVNNQQSMSADLDDPFILLYDKKISNVRDLLPVLEGVAKAGKPLLIVAEEVEGEALATLVVNTIRGIVKVCAVKAPGFGDRRKAMLEDMAILTGGVVISEEVGLSLEKATIKDLGRAKKIQVSKENTTIIDGAGEGAGIEARIKQIKAQIEETSSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALIRAKAAIAGIKGVNEDQNHGIQIALRAMEAPLREIVTNAGDEPSVILNRVVEGSGAFGYNAANGEFGDMIEFGILDPTKVTRTALQNAASIAGLMITTEAMVAEAPKKDEPAMPAGGGMGGMGGMDF Kraken2_NC_006625.1 IMICODJL_14344 Prodigal:2.6 10746 11333 + VFG048996(gb|WP_004213609) 99.5 7.77e-146 (rmpA) regulator of mucoid phenotype RmpA VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MLTDDYFFYYGLKQLTGLPLFHITYEGVVNKSIAIKHKRNIRVLVDSRIFYSGKWGGYKMLRGSLNMISQWMWLDVSGGGRFYPKGCDYDIYVNMQGNVKNNIEKLYFAFLKKNVSRIVNHYPRLTKKEQAVLQCLLKNGGINEIKSQLKIEEKTLSCYQSKITRKFGCKRYIRFMYLYSLNKEMVDERWLMPSI Kraken2_NC_006625.1 IMICODJL_14348 Prodigal:2.6 13666 15840 - VFG048547(gb|WP_004213617) 100.0 0.0 (iroN) salmochelin receptor IroN VF0563 Sal Salmochelin VFC0272 Nutritional/Metabolic factor Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection Inducing dissemination through chelation of host cellular iron, leading to inactivation of iron-dependent prolyl hydroxylases and the master transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) stabilization in lung epithelial cells. HIF-1alpha controls vascular permeability and inflammatory gene expression MRINKILWPSIALLAGLNSQVSVAKSYDDNDETLVVVATAEQVLKQQPGVSIITSEDIKKTPPVNDLSDIIRKMPGVNLTGNSASGTRGNNRQIDIRGMGPENTLILIDGVPVTSRNSVRYSWRGERDTRGDTNWVPPEQVERIEVIRGPAAARYGSGAAGGVVNIITKRPSNDWHGSLSLYTNQPESSDEGATHRTNFSLSGPLAGDALTMHLYGNLNKTDADSWDINSSAGTKNAAGHEGVRNKDINGVVSWKLNPQQILDFEAGYSRQGNIYAGDTQNSSSSAVTENLAKSRKETNRLYRQNYGIAHNGIWDWGQSRFGVYYEKTNNNRMNEGLSGGSEGRILADEKFTTNRLSSWRTSGEINIPLNEPVDQTLTVGVEWSRDKLDAPSSTSLTVNDSDIGGISGSAADRSSKNHSQISALYIDDNIEPVPGTNIISGLRFDYLNESGGNFSPSLNLSQELGDYFKVKAGIARTFKAPNLYQSSKGYLLYSKGNGCPKDITSGGCYLKGNKDLDPEISINKEIGLEFAWEDYYASVTYFRNDYQNKIVAGDNAIGQTASGAYILQWQNGGKALVDGIEASMAFPLVKDRLNWNTNATWMITSEQKDTGNPLSIIPKYTINNSLDWTITQAFSASVNWTLYGRQKPRTHAESRSEDTRGMSGKVLGAYSLVGTNFNYDINKNLRLNIGVSNILDKQIYRTSEGASTYNEPGRAYYVGAVVSF Kraken2_NC_006625.1 IMICODJL_14349 Prodigal:2.6 16300 17529 - VFG048554(gb|WP_004902400) 100.0 3.85e-309 (iroD) siderophore esterase IroD VF0563 Sal Salmochelin VFC0272 Nutritional/Metabolic factor Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection Inducing dissemination through chelation of host cellular iron, leading to inactivation of iron-dependent prolyl hydroxylases and the master transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) stabilization in lung epithelial cells. HIF-1alpha controls vascular permeability and inflammatory gene expression MLNMQQHPSAIARLRSQLAAGHIANVSDFWRDAESLNGPLVMPVEGAEDEREVTFLWRAWHSLQGVYLRLNRVTDKEHVAKGMMTPLPETDIWTLTLRLPASYCGSYSLIEIPLGTPAKRIAQAGGRFAALPGHADPLNKTPRISVRGSSQESVLTLDKAPAQPEWSGGSPTGQLLTSSRIIAGQSRRVQLYMPDVDVLQPLGLVVLPDGETWFDHLGVCAAIDVAINNGRIVPVAIMGIDNIDEHERNAILGGRSELITDIARHLLPTIRAEQPQRQWADRSRTVLAGQSLGGVSALIAARHAPETFGLALSHSPSMWWTPEGACRPNLFRETDTSWVSEHLLSAPPQNVRIRLCVGSLEGSTVLHVQQLHQRLLNAGVDSHYAIYTGGHDYAWWRGALIDGLGLLKG Kraken2_NC_006625.1 IMICODJL_14350 Prodigal:2.6 17634 21278 - VFG048551(gb|WP_011251260) 100.0 0.0 (iroC) ABC transporter VF0563 Sal Salmochelin VFC0272 Nutritional/Metabolic factor Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection Inducing dissemination through chelation of host cellular iron, leading to inactivation of iron-dependent prolyl hydroxylases and the master transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) stabilization in lung epithelial cells. HIF-1alpha controls vascular permeability and inflammatory gene expression MPATHSPTPARSWIVRLARVCWERKKLTIIVVVASVSTILLAALTPLLTRQAVNDALAGNPTRLPRLACGLLLIAFFDFIGNYVRRGYAGELSLWVQHTLRGRAFDSIQKLDGAGQDALRTGQVISRTNSDLQQVHTLLQMCPVPLAVFTYYIAGIAVMLWMSPAMTLIVVCVLACLAITALRARRRVFAQTGLASDRLANLTEHMREVLAQISVVKSCVAELRETRWLDRQSRQIVHVRIGAAISQAIPGATMLALPVLGQIVLLCYGGWSIIHGRINLGTFVAFASFLAMLTGPTRVLASFLVIAQRTQASVERVFALIDTRSQMEDGTEVVNGQVVGLELENMSFDYRGGRRILSDVSFSLHAGETVAVVGASGSGKSTLLMLLARFYDPSAGDIWLNTSAGRHNLRALRLEALRRRIGVVFEDAFLFAGTVAENIAYGHPQATADDIYRAATAAGASDFINALPKGFDTWLTERGTNLSGGQRQRIALARALITAPEVLILDDTTSAVDAGTEAEINTALSRYADEEHMLLVIARRRSTLQLASRIVMLDKGRVVDTGTQAELEARCPAFRALMTGDGDFLAPSHSENNELWPTGPAAQDYAPETGDKGFVARMTRVPENAVQQALAGKGRKVTSLLKPVAWMFVIAALLIALDSAAGVGVLILLQRGIDSGVAAGDMSTIGLCVLLALCLVAVSWSCYSLQTVFAARAAESVQHTVRVRTFGHMLRLGLPWHEKHVDSRLTRMTVDVDSLARFLQNGLAGAATSLVTMFAIAAAMFWLDPLLALTALSAVPQVALATWIYRRLSSPAYAQARLEIGKVNSTLQEKVSGLRVVQSHGQQEQEAARLRALSDRFRTTRVRAQKYLAVYFPFLTFCTEASYAAVLLVGASRVAEGEMTAGVMAAFYLLLGQFYGPVQQLSGIVDAWQQATASGKHIDELLATEGTENVTPSSAPPATGALHLDDVTFSYPDSSEPALTKLTLTIPEGTVVAVVGRSGAGKSTLIKLIAGLYSPTYGSISIGDRTIDDASLADYRLQIGVVDQDVALFSSDIAENIRYSRPSSTNDDVEIASLRAGLYETVRNLPQGFRTPVSNGGADLSAGQRQLIALARAQLANAHILLLDEATSRLDRASEERLMSSLIDVAHARQHSALIVAHRLTTAQRCELIAVLDKGQLTEYGTHEQLLAAGGLYNQLWHDSVGSTVLHRQHDIAG Kraken2_NC_006625.1 IMICODJL_14351 Prodigal:2.6 21421 22536 - VFG048550(gb|WP_004213623) 100.0 9.99e-279 (iroB) glucosyltransferase IroB VF0563 Sal Salmochelin VFC0272 Nutritional/Metabolic factor Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection Inducing dissemination through chelation of host cellular iron, leading to inactivation of iron-dependent prolyl hydroxylases and the master transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) stabilization in lung epithelial cells. HIF-1alpha controls vascular permeability and inflammatory gene expression MRILFIGPPLYGLLYPVLSLAQAFRVNGHEVLIASGGKFVKKAAEAGLVAFDAAPGLDSEAGYCRHEALRKESHIGTKMGNFSFFSEEMADHLVEFAGHWRPDLIIYPPLGVIGPLIAAKYDIPVVMQTVGFGHTPWHIKGVTRSLADTYHRHGVGAAPRDMAWIDVAPPSMSILENDGEPIIPMQYVPYNGGAVWEPWWERKPDRKRLLVSLGTVKPMVDGLELITWVLDSASEVDAEIILHLPANARSDLRSLPSNVRLVDWIPMGAFLNGADGFIHHGGAGNTLTALHAGIPQIVFGQGADRPVNARVVVERGCGIIPGDGGLSSNMINAFLDNRALRDASEEVAAEMATLPCPSEVAKNLIAMVQKG Kraken2_NC_006625.1 IMICODJL_14405 Prodigal:2.6 64752 65774 + VFG013197(gb|WP_011608705) 66.5 1.41e-154 (hemB) porphobilinogen synthase VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MSIIIPGSFPARRLRRSRTHSFSRRLVAENQLTVNDLILPVFIIEGQNLRQEVPSMPGVFRLSVDMLLHDAAQFVQAGIPAIALFPCIESSAKSLMADASWDPSGLVPRTVRALKKAFPELGVITDVALDAYTSHGQDGIIDEHGYVLNEPTKEILTRQALTHAEAGADIVAPSDMMDGRIGHIRQAFETNGLLTIQIMAYSAKYASNYYGPFREATQSAMALGKRDKKNYQMDPANAMEALHEIAQDLQEGADMVMVKPGMPYLDIIREARKTFAVPVFAYQVSGEYAMHMAAFRHGWLDEEQTVLESLICFKRAGADGILTYFASSVAQWLNQHQREY Kraken2_NC_006625.1 IMICODJL_14448 Prodigal:2.6 102504 103889 - VFG034652(gb|WP_000074204) 72.3 7.28e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSSVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NC_006625.1 IMICODJL_14568 Prodigal:2.6 204155 204454 + VFG048998(gb|WP_011154608) 100.0 5.3499999999999995e-68 (rmpA2) regulator of mucoid phenotype RmpA2 VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MEKYIYFMCNKDVTLVLTDDYYFYFGLKQLTGLPLVYITYEGSMDKPIVIKQKRNIRVLVDSRIFYSGKWDGYKMLRKTLNMISQWMWLDISGGGEVLS Kraken2_NC_006625.1 IMICODJL_14578 Prodigal:2.6 209679 211877 - VFG048621(gb|WP_004213924) 100.0 0.0 (iutA) ferric aerobactin receptor IutA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNIDRIEVISGATSLYGGGSTGGLINIVTKKGQPETIMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTERHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAAFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIAAGKATSADAIPGGSVDYDNFLFNAGLLMHITERQQAWLNFSQGVELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTVDLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF Kraken2_NC_006625.1 IMICODJL_14579 Prodigal:2.6 211962 213239 - VFG048609(gb|WP_004213923) 100.0 0.0 (iucD) lysine 6-monooxygenase IucD VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MTNTVDFIGIGIGPFNLSIAALSHQAEGLSSRFFDGRPHFAWHPGMLVPDCHMQTMFLKDLVSAVAPTSPYSFVNYLVKRKKFYRFLTTELRTVSRDEFSDYLRWAAEGMNNLHFNHTVESIDFDERHQRFVVQTSQGESVARNICLGIGKQPHLPPCVKTATQTCFHASEMSLRRPDLGGKRVSVVGGGQSGADLFLNALRGEWGDVAEISWVSRRNNFNALDEAAFANEYFTPEYVSGFVGLNERARQKMLDEQKMTSDGITADSLLTIYRELYHRFEVLRQPRNARLLPSRSVTGLESRGQSWQLLLEHHLDNGYDTLESDVVIFATGYRPALPQILSPLMSRIAMRDECNFKVRDDFTLEWNGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARILNRVMGRDLFDLSMPPALIQWRSGT Kraken2_NC_006625.1 IMICODJL_14580 Prodigal:2.6 213243 214976 - VFG048606(gb|WP_004213922) 100.0 0.0 (iucC) aerobactin siderophore biosynthesis protein IucC VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MNHKDWDFVNRQLVAKMLAELEYEQVFHAESQGDGRYCINLPGAQWRFSAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKPVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLIDLDADRLQCLLSGHPKFAFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMVWRCDSELDIQQLLAAAMDPQEFARFNQVWQDNGLDNDWLPLPVHPWQWQQKISLDFIADLAEGRMVSLGEFGDLWLAQQSLRTLTNASRQGGLDIKLPLTIYNTSCYRGIPGKYIAAGPLASRWLQQVFATDATLKQSGAVILGEPAAGYVSHEGYAALAQAPYRYQEMLGVIWRENPCRWLKPDESPILMATLMECDENNQPLIGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKKGVPQRVLLKDFQGDMRLVKDAFPEMDSLPQEVRDVTARLSADYLIHDLQTGHFVTVLRFVSPLMARLGVPERRFYQLLAAVLSDYMQEHPQMSARFALFSLFKPQIIRVVLNPVKLTWHDQDGGSRMLPNYLEDLQNPLWLATRD Kraken2_NC_006625.1 IMICODJL_14581 Prodigal:2.6 214976 215923 - VFG048603(gb|WP_004213921) 100.0 2.6100000000000003e-248 (iucB) N-acetyltransferase IucB VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MSKANIVHSGYGLRCEKLDKPLNLSWGLDNSAVLHWPGPLPTGWLRDALEQIFIAAPQLSAVVLPWAEWREEPQALTLFGQVKSDIIHRTAFWQLPLWLSSPANRASGEMVFDAEREIYFPLRPPRPQGEVYRRYDPRVRKTLSFRVADPVLDAERFTRWMNDPRVEYFWEQSGSLEVQTAYLERQLTGKHAFPLIGCFDDRPFSYFEIYWAAEDRIGRHYSWQPFDRGLHLLVGEQQWRGAHYVQSWLRGLTHYLLLDEPRTQRTVLEPRADNQRLFRHLEPAGYRTIKEFDFPHKRSRMVMADRHHFFTEVGL Kraken2_NC_006625.1 IMICODJL_14582 Prodigal:2.6 215924 217705 - VFG048600(gb|WP_004213920) 100.0 0.0 (iucA) aerobactin Synthetase IucA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MGIFIDKILIIMTSEICLTMTLPTKTSTLDVAAQCFLNSLVRETKDWRLTEYQPTQLIIPLGEQQALHFRVAYFSPTQHHRFEFPARLVTASGSHPVDFATLSRLIVDKLQHQLLLPATSCETFHQRVMESHAHTQQAIDARHDWAALREKALNFGEAEQALLVGHAFHPAPKSHEPFNQQEAERYLPDFAPHFPLRWFAVNKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLHPWQGEYLLQQEWCQELVAKGLIKDLGEAGAPWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVKRGMRLARLAQTDDWQTLQARFPTFRVMQEDGWAGLRDLHGNIMQESLFALRENLLVDQPQSQTNVLVSLTQAAPDGGDSLLVAAVKRLSDRLGITAQQAAHAWVDAYCHQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGLIYRDCQGSAFMPHAAGWLDTIGEAQAENVFTREQLLRYFPYYLLVNSTFAVTAALGAAGLDSEANLMARVRTLLAEMRDQVTHKTCLNYVLENPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLLAQEG Kraken2_NC_017541.1 IMICODJL_14609 Prodigal:2.6 15999 16343 + VFG048998(gb|WP_011154608) 95.1 2.45e-68 (rmpA2) regulator of mucoid phenotype RmpA2 VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MEKYIYFMCNKDVTLVLTDDYYFYFGLKQLTGLPLVYITYEGSMDKPIVIKQKRNIRVLVDSRIFYSGKWDGYKMLRKTLNMISQWMWLDISGGGRSFILKGVIMTSMSTCKEI Kraken2_NC_017541.1 IMICODJL_14619 Prodigal:2.6 21524 23722 - VFG048621(gb|WP_004213924) 100.0 0.0 (iutA) ferric aerobactin receptor IutA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNIDRIEVISGATSLYGGGSTGGLINIVTKKGQPETIMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTERHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAAFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIAAGKATSADAIPGGSVDYDNFLFNAGLLMHITERQQAWLNFSQGVELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTVDLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF Kraken2_NC_017541.1 IMICODJL_14620 Prodigal:2.6 23807 25084 - VFG048608(gb|WP_014599302) 100.0 0.0 (iucD) lysine 6-monooxygenase IucD VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MTNTVDFIGIGIGPFNLSIAALSHQAEGLSSRFFDGRPHFAWHPGMLVPDCHMQTMFLKDLVSAVAPTSPYSFVNYLVKRKKFYRFLTTELCTVSRDEFSDYLRWAAEGMNNLHFNHTVESIDFDERHQRFVVQTSQGESVARNICLGIGKQPHLPPCVKTATQTCFHASEMSLRRPDLGGKRVSVVGGGQSGADLFLNALRGEWGDVAEISWVSRRNNFNALDEAAFANEYFTPEYVSGFVGLNERARQKMLDEQKMTSDGITADSLLTIYRELYHRFEVLRQPRNARLLPSRSVTGLESRGQSWQLLLEHHLDNGYDTLESDVVIFATGYRPALPQILSPLMSRIAMRDECNFKVRDDFTLEWNGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARILNRVMGRDLFDLSMPPALIQWRSGT Kraken2_NC_017541.1 IMICODJL_14621 Prodigal:2.6 25088 26821 - VFG048606(gb|WP_004213922) 100.0 0.0 (iucC) aerobactin siderophore biosynthesis protein IucC VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MNHKDWDFVNRQLVAKMLAELEYEQVFHAESQGDGRYCINLPGAQWRFSAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKPVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLIDLDADRLQCLLSGHPKFAFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMVWRCDSELDIQQLLAAAMDPQEFARFNQVWQDNGLDNDWLPLPVHPWQWQQKISLDFIADLAEGRMVSLGEFGDLWLAQQSLRTLTNASRQGGLDIKLPLTIYNTSCYRGIPGKYIAAGPLASRWLQQVFATDATLKQSGAVILGEPAAGYVSHEGYAALAQAPYRYQEMLGVIWRENPCRWLKPDESPILMATLMECDENNQPLIGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKKGVPQRVLLKDFQGDMRLVKDAFPEMDSLPQEVRDVTARLSADYLIHDLQTGHFVTVLRFVSPLMARLGVPERRFYQLLAAVLSDYMQEHPQMSARFALFSLFKPQIIRVVLNPVKLTWHDQDGGSRMLPNYLEDLQNPLWLATRD Kraken2_NC_017541.1 IMICODJL_14622 Prodigal:2.6 26821 27768 - VFG048603(gb|WP_004213921) 100.0 2.6100000000000003e-248 (iucB) N-acetyltransferase IucB VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MSKANIVHSGYGLRCEKLDKPLNLSWGLDNSAVLHWPGPLPTGWLRDALEQIFIAAPQLSAVVLPWAEWREEPQALTLFGQVKSDIIHRTAFWQLPLWLSSPANRASGEMVFDAEREIYFPLRPPRPQGEVYRRYDPRVRKTLSFRVADPVLDAERFTRWMNDPRVEYFWEQSGSLEVQTAYLERQLTGKHAFPLIGCFDDRPFSYFEIYWAAEDRIGRHYSWQPFDRGLHLLVGEQQWRGAHYVQSWLRGLTHYLLLDEPRTQRTVLEPRADNQRLFRHLEPAGYRTIKEFDFPHKRSRMVMADRHHFFTEVGL Kraken2_NC_017541.1 IMICODJL_14623 Prodigal:2.6 27769 29550 - VFG048600(gb|WP_004213920) 100.0 0.0 (iucA) aerobactin Synthetase IucA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MGIFIDKILIIMTSEICLTMTLPTKTSTLDVAAQCFLNSLVRETKDWRLTEYQPTQLIIPLGEQQALHFRVAYFSPTQHHRFEFPARLVTASGSHPVDFATLSRLIVDKLQHQLLLPATSCETFHQRVMESHAHTQQAIDARHDWAALREKALNFGEAEQALLVGHAFHPAPKSHEPFNQQEAERYLPDFAPHFPLRWFAVNKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLHPWQGEYLLQQEWCQELVAKGLIKDLGEAGAPWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVKRGMRLARLAQTDDWQTLQARFPTFRVMQEDGWAGLRDLHGNIMQESLFALRENLLVDQPQSQTNVLVSLTQAAPDGGDSLLVAAVKRLSDRLGITAQQAAHAWVDAYCHQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGLIYRDCQGSAFMPHAAGWLDTIGEAQAENVFTREQLLRYFPYYLLVNSTFAVTAALGAAGLDSEANLMARVRTLLAEMRDQVTHKTCLNYVLENPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLLAQEG Kraken2_NC_017541.1 IMICODJL_14650 Prodigal:2.6 52768 54153 + VFG034652(gb|WP_000074204) 72.1 1.03e-226 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSSVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAVDANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NC_017541.1 IMICODJL_14678 Prodigal:2.6 81618 82640 - VFG013197(gb|WP_011608705) 66.5 1.41e-154 (hemB) porphobilinogen synthase VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MSIIIPGSFPARRLRRSRTHSFSRRLVAENQLTVNDLILPVFIIEGQNLRQEVPSMPGVFRLSVDMLLHDAAQFVQAGIPAIALFPCIESSAKSLMADASWDPSGLVPRTVRALKKAFPELGVITDVALDAYTSHGQDGIIDEHGYVLNEPTKEILTRQALTHAEAGADIVAPSDMMDGRIGHIRQAFETNGLLTIQIMAYSAKYASNYYGPFREATQSAMALGKRDKKNYQMDPANAMEALHEIAQDLQEGADMVMVKPGMPYLDIIREARKTFAVPVFAYQVSGEYAMHMAAFRHGWLDEEQTVLESLICFKRAGADGILTYFASSVAQWLNQHQREY Kraken2_NC_017541.1 IMICODJL_14806 Prodigal:2.6 179840 180427 + VFG048994(gb|WP_014599332) 99.5 1.1e-145 (rmpA) regulator of mucoid phenotype RmpA VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MLTDDYFFYYGLKQLTGLPLFHITYEGVVNKSIAIKHKRNIRVLVDSRIFYSGKWGGYKMLRGSLNMISQWMWLDVSGGGRFYPKGCDYDIYVNMQGNVKNNIEKLYFAFLKKNVSRIVNHYPRLTKKEQAVLQCLLKNGGINEIKSQLKIEEKTLSCYQSKITRKFDCKRYIRFMYLYSLNKEMVDERWLMPSI Kraken2_NC_017541.1 IMICODJL_14810 Prodigal:2.6 182759 184933 - VFG048547(gb|WP_004213617) 99.6 0.0 (iroN) salmochelin receptor IroN VF0563 Sal Salmochelin VFC0272 Nutritional/Metabolic factor Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection Inducing dissemination through chelation of host cellular iron, leading to inactivation of iron-dependent prolyl hydroxylases and the master transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) stabilization in lung epithelial cells. HIF-1alpha controls vascular permeability and inflammatory gene expression MRINKILWPSIALLAGLNSQVSVAKSYDDNDETLVVVATAEQVLKQQPGVSIITSEDIKKTPPVNDLSDIIRKMPGVNLTGNSASGTRGNNRQIDIRGMGPENTLILIDGVPVTSRNSVRYSWRGERDTRGDTNWVPPEQVERIEVIRGPAAARYGSGAAGGVVNIITKRPSNDWHGSLSLYTNQPESSDEGATHRTNFSLSGPLAGDALTMHLYGNLNKTDADSWDINSSAGTKNAAGHEGVRNKDINGVVSWKLNSQQILDFEVGYSRQGNIYAGDTQNSSSSAVTENLAKSRKETNRLYRQNCGIAHNGIWDWGQSRFGVYYEKTNNNRMNEGLSGGSEGRILADEKFTTNRLSSWRTSGEINIPLNEPVDQTLTVGVEWSRDKLDAPSSTSLTVNDSDIGGISGSAADRSSKNHSQISALYIDDNIEPVPGTNIISGLRFDYLNESGGNFSPSLNLSQELGDYFKVKAGIARTFKAPNLYQSSKGYLLYSKGNGCPKDITSGGCYLKGNKDLDPEISINKEIGLEFAWEDYYASVTYFRNDYQNKIVAGDNAIGQTASGAYILQWQNGGKALVDGIEASMAFPLVKDRLNWNTNATWMITSEQKDTGNPLSIIPKYTINNSLDWTITQAFSASVNWTLYGRQKPRTHAESRSEDTRGMSGKVLGAYSLVGTNFNYDINKNLRLNIGVSNILDKQIYRTSEGASTYNEPGRAYYVGAVVSF Kraken2_NC_017541.1 IMICODJL_14811 Prodigal:2.6 185393 186622 - VFG048554(gb|WP_004902400) 100.0 3.85e-309 (iroD) siderophore esterase IroD VF0563 Sal Salmochelin VFC0272 Nutritional/Metabolic factor Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection Inducing dissemination through chelation of host cellular iron, leading to inactivation of iron-dependent prolyl hydroxylases and the master transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) stabilization in lung epithelial cells. HIF-1alpha controls vascular permeability and inflammatory gene expression MLNMQQHPSAIARLRSQLAAGHIANVSDFWRDAESLNGPLVMPVEGAEDEREVTFLWRAWHSLQGVYLRLNRVTDKEHVAKGMMTPLPETDIWTLTLRLPASYCGSYSLIEIPLGTPAKRIAQAGGRFAALPGHADPLNKTPRISVRGSSQESVLTLDKAPAQPEWSGGSPTGQLLTSSRIIAGQSRRVQLYMPDVDVLQPLGLVVLPDGETWFDHLGVCAAIDVAINNGRIVPVAIMGIDNIDEHERNAILGGRSELITDIARHLLPTIRAEQPQRQWADRSRTVLAGQSLGGVSALIAARHAPETFGLALSHSPSMWWTPEGACRPNLFRETDTSWVSEHLLSAPPQNVRIRLCVGSLEGSTVLHVQQLHQRLLNAGVDSHYAIYTGGHDYAWWRGALIDGLGLLKG Kraken2_NC_017541.1 IMICODJL_14812 Prodigal:2.6 186727 190371 - VFG048551(gb|WP_011251260) 99.8 0.0 (iroC) ABC transporter VF0563 Sal Salmochelin VFC0272 Nutritional/Metabolic factor Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection Inducing dissemination through chelation of host cellular iron, leading to inactivation of iron-dependent prolyl hydroxylases and the master transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) stabilization in lung epithelial cells. HIF-1alpha controls vascular permeability and inflammatory gene expression MPATHSPTPARSWIVRLARVCWERKKLTIIVVVASVSTILLAALTPLLTRQAVNDALAGNPTRLPRLACGLLLIAFFDFIGNYVRRGYAGELSFWVQHTLRGRAFDSIQKLDGAGQDALRTGQVISRTNSDLQQVHTLLQMCPVPLAVFTYYIAGIAVMLWMSPAMTLIVVCVLACLAITALRARRRVFAQTGLASDRLANLTEHMREVLAQISVVKSCVAELRETRWLDRQSRQIVHVRIGAAISQAIPSATMLALPVLGQIVLLCYGGWSIIHGRINLGTFVAFASFLAMLTGPTRVLASFLVIAQRTQASVERVFALIDTRSQMEDGTEVVNGQVVGLELENMSFDYRGGRRILSDVSFSLHAGETVAVVGASGSGKSTLLMLLARFYDPSAGDIWLNTSAGRHNLRALRLEALRRRIGVVFEDAFLFAGTVAENIAYGHPQATADDIYRAATAAGASDFINALPKGFDTWLTERGTNLSGGQRQRIALARALITAPEVLILDDTTSAVDAGTEAEINTALSRYADEEHMLLVIARRRSTLQLASRIVMLDKGRVVDTGTQAELEARCPAFRALMTGDGDFLAPSHSENNELWPTGPAAQDYAPETGDKGFVARMTRVPENAVQQALAGKGRKVTSLLKPVAWMFVIAALLIALDSAAGVGVLILLQRGIDSGVAAGDMSTIGLCVLLALCLVAVSWSCYSLQTVFAARAAESVQHTVRVRTFGHMLRLGLPWHEKHVDSRLTRMTVDVDSLARFLQNGLAGAATSLVTMFAIAAAMFWLDPLLALTALSAVPQVALATWIYRRLSSPAYAQARLEIGKVNSTLQEKVSGLRVVQSHGQQEQEAARLRALSDRFRTTRVRAQKYLAVYFPFLTFCTEASYAAVLLVGASRVAEGEMTAGVMAAFYLLLGQFYGPVQQLSGIVDAWQQATASGKHIDELLATEGTENVTPSSAPPATGALHLDDVTFSYPDSSEPALTKLTLTIPEGTVVAVVGRSGAGKSTLIKLIAGLYSPTYGSISIGDRTIDDASLADYRLQIGVVDQDVALFSSDIAENIRYSRPSSTNDDVEIASLRAGLYETVRNLPQGFRTPVSNGGADLSAGQRQLIALARAQLANAHILLLDEATSRLDRASEERLMSSLIDVAHARQHSALIVAHRLTTAQRCELIAVLDKGQLTEYGTHEQLLAAGGLYNQLWHDSVGSTVLHRQHDIAG Kraken2_NC_017541.1 IMICODJL_14813 Prodigal:2.6 190514 191629 - VFG048550(gb|WP_004213623) 100.0 9.99e-279 (iroB) glucosyltransferase IroB VF0563 Sal Salmochelin VFC0272 Nutritional/Metabolic factor Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection Inducing dissemination through chelation of host cellular iron, leading to inactivation of iron-dependent prolyl hydroxylases and the master transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) stabilization in lung epithelial cells. HIF-1alpha controls vascular permeability and inflammatory gene expression MRILFIGPPLYGLLYPVLSLAQAFRVNGHEVLIASGGKFVKKAAEAGLVAFDAAPGLDSEAGYCRHEALRKESHIGTKMGNFSFFSEEMADHLVEFAGHWRPDLIIYPPLGVIGPLIAAKYDIPVVMQTVGFGHTPWHIKGVTRSLADTYHRHGVGAAPRDMAWIDVAPPSMSILENDGEPIIPMQYVPYNGGAVWEPWWERKPDRKRLLVSLGTVKPMVDGLELITWVLDSASEVDAEIILHLPANARSDLRSLPSNVRLVDWIPMGAFLNGADGFIHHGGAGNTLTALHAGIPQIVFGQGADRPVNARVVVERGCGIIPGDGGLSSNMINAFLDNRALRDASEEVAAEMATLPCPSEVAKNLIAMVQKG Kraken2_NZ_CP006927.1 IMICODJL_15195 Prodigal:2.6 69452 70837 - VFG034652(gb|WP_000074204) 72.3 1.79e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALNNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYNGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_CP007729.1 IMICODJL_15428 Prodigal:2.6 116870 118255 - VFG034652(gb|WP_000074204) 72.3 1.79e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALNNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYNGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_CP008829.1 IMICODJL_16197 Prodigal:2.6 116870 118255 - VFG034652(gb|WP_000074204) 72.3 1.79e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALNNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYNGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_CP009879.1 IMICODJL_16734 Prodigal:2.6 145782 146438 - VFG014116(gb|NP_251832) 61.4 1.44e-29 (PA3142) hypothetical protein VF0085 LPS VFC0258 Immune modulation Two distinct forms of LPS: A-band and B-band. A-band is a homopolymer of alpha-linked D-rhamnose, whereas B-band LPS is a heteropolymer Mediates biological effects including resistance to serum killing and phagocytosis; the binding to normal CFTR (cystic fibrosis transmembrane conductance regulator) and invasion of host cells may make a contribution to virulence in the human eye; internalization by binding to normal CFTR protein expressed by airway epithelial cells followed by desquamation of bacteria-laden epithelial cells, constitutes a host defense mechanism. If this mechanism fails to function properly, abnormally high bacterial carriage would promote the establishment of chronic bacterial infection Binding interaction occurs between the first extracellular loop of CFTR (predicted to be in amino acids 108-117 of the mature protein) and the complete outer portion of the core polysaccharide of the LPS MLMCDATGMSQRRACRLTGLSLSTCRYEAHRPAADAHLSGRITELALERRRFGYRRIWQLLRREGLHVNHKRVYRLYHLSGLGVKRRRRRKVLATERLPLLRPAAPNLTWSMDSVMDALSTGRRIKCLTCVDDFTKECLTVTVAFGISGVQVSRILDSIALFRGYPATIRTDQGPEFTCRALDQWAFEHGVELRLIQPGSQRRTDLLRALTDDFAMNA Kraken2_NZ_CP009879.1 IMICODJL_16755 Prodigal:2.6 170547 171932 + VFG034652(gb|WP_000074204) 72.3 1.79e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALNNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYNGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_CP009865.1 IMICODJL_17023 Prodigal:2.6 107724 109109 - VFG034652(gb|WP_000074204) 72.3 1.79e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALNNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYNGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_CP009865.1 IMICODJL_17059 Prodigal:2.6 142423 143037 - VFG014116(gb|NP_251832) 64.6 9.92e-38 (PA3142) hypothetical protein VF0085 LPS VFC0258 Immune modulation Two distinct forms of LPS: A-band and B-band. A-band is a homopolymer of alpha-linked D-rhamnose, whereas B-band LPS is a heteropolymer Mediates biological effects including resistance to serum killing and phagocytosis; the binding to normal CFTR (cystic fibrosis transmembrane conductance regulator) and invasion of host cells may make a contribution to virulence in the human eye; internalization by binding to normal CFTR protein expressed by airway epithelial cells followed by desquamation of bacteria-laden epithelial cells, constitutes a host defense mechanism. If this mechanism fails to function properly, abnormally high bacterial carriage would promote the establishment of chronic bacterial infection Binding interaction occurs between the first extracellular loop of CFTR (predicted to be in amino acids 108-117 of the mature protein) and the complete outer portion of the core polysaccharide of the LPS MYRLYHLSGLGVKRRRRRKGLATERLPLLRPAAPNLTWSMDFVMDALSTGRRIKCLTCVDDFTKECLTVTVAFGISGVQVSRILDSIALFRGYPATIRTDQGPEFTCRALDQWAFEHGVELRLIQPGKPTQNGFIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPHSALNYQTPSEFAARWRNEKCEGKQTDLTN Kraken2_NZ_CP009777.1 IMICODJL_17300 Prodigal:2.6 70122 71507 - VFG034652(gb|WP_000074204) 72.3 1.79e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALNNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYNGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_CP008930.1 IMICODJL_17781 Prodigal:2.6 115010 116395 - VFG034652(gb|WP_000074204) 72.3 1.79e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALNNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYNGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_CP065638.1 IMICODJL_19054 Prodigal:2.6 2779 3465 - VFG001445(gb|AAA92657) 73.9 3.05e-106 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MCPTDRRERTLASQSVNKYILSIQDIYKNSPVPVCVRNQSRKIIYANGAFIELFSKEDQPLSGDSYNRYGVEVFLSSLELECQSLGHGAAFCRRFNFHGEIYQIRMENISFDNNEIIVLWQINLFPDHPFFSPDTKTKNLSLSGTESFWNELSPGTLLVFSFYTLGVSHANIAKELGITIRASEDRIKPVKRKIKRNYESFDSFRISCISKGKIISLIDIIREFYCVK Kraken2_NZ_CP065638.1 IMICODJL_19086 Prodigal:2.6 26784 27524 + VFG002301(gb|NP_490536) 100.0 2.74e-170 (mig-5) putative carbonic anhydrase VF0396 Mig-5 Macrophage-inducible gene-5 VFC0325 Antimicrobial activity/Competitive advantage Mig-5 was found to be expressed by Salmonella when ingested by macrophages. mig-5 codes for the carbonic anhydrase which catalyses the hydratation of carbon dioxide and formation of HCO3-. The biological meaning of this reaction in intracellularilly residing of Salmonella is, however, not known. MEQNQPAQPSRRAILKQTLAVSALSVTGLAALSVPTISFAASLSKEERDGMTPDAVIEHFKQGNLRFRENRPAKHDYLAQKRNSIAGQYPAAVILSCIDSRAPAEIVLDAGIGETFNSRVAGNISNRDMLGSMEFACAVAGAKVVLVIGHTRCGAVRCAIDNAELGNLTGLLDEIKPAIAKTEYSGERKGSNYDFVDAVARKNVELTIENIRKNSPVLKQLEDEKKIKIVGSMYHLTGGKVEFFEV Kraken2_NZ_CP065638.1 IMICODJL_19096 Prodigal:2.6 35086 36861 + VFG000439(gb|NP_490529) 100.0 0.0 (spvB) type III secretion system effector SpvB, ADP-ribosylation activity VF0107 SpvB VFC0235 Exotoxin PDB accession: 2GWL SpvB-mediated actin depolymerization is associated with an accumulation of cells in the G2/M phase, eventually resulting in apoptotic cell death An ADP-ribosylating toxin that modifies actin directly and totally disrupt the cytoskeleton of the cell MLILNGFSSATLALITPPFLPKGGKALSQSGPDGLASITLPLPISAERGFAPALALHYSSGGGNGPFGVGWSCATMSIARRTSHGVPQYNDSDEFLGPDGEVLVQTLSTGDAPNPVTCFAYGDVSFPQSYTVTRYQPRTESSFYRLEYWVGNSNGDDFWLLHDSNGILHLLGKTAAARLSDPQAASHTAQWLVEESVTPAGEHIYYSYLAENGDNVDLNGNEAGRDRSAMRYLSKVQYGNATPAADLYLWTSATPAVQWLFTLVFDYGERGVDPQVPPAFTAQNSWLARQDPFSLYNYGFEIRLHRLCRQVLMFHHFPDELGEADTLVSRLLLEYDENPILTQLCAARTLAYEGDGYRRAPVNNMMPPPPPPPMMGGNSSRPKSKWAIVEESKQIQALRYYSAQGYSVINKYLRGDDYPETQAKETLLSRDYLSTNEPSDEEFKNAMSVYINDIAEGLSSLPETDHRVVYRGLKLDKPALSDVLKEYTTIGNIIIDKAFMSTSPDKAWINDTILNIYLEKGHKGRILGDVAHFKGEAEMLFPPNTKLKIESIVNCGSQDFASQLSKLRLSDDATADTNRIKRIINMRVLNS Kraken2_NZ_CP065638.1 IMICODJL_19097 Prodigal:2.6 37143 37868 + VFG000438(gb|NP_490528) 100.0 2.2e-178 (spvC) type III secretion system effector SpvC, phosphothreonine lyase VF0947 TTSS-2 secreted effectors VFC0086 Effector delivery system GogB; PipB; PipB2 (Directly binds kinesin, a plus end-directed microtubule motor protein. Localizes to the phagosome; Promotes Sif extension, recuits kinesin-1 to SCV. ); SifA (GEF. Localizes to the cytosolic face of the SCV and binds to host protein-kinesin-binding protein SKIP to modulate phagosome tubulation; required for SCV membrane integrity and Sif formation; maintains perinuclear SCV positioning; redirects exocytic vesicles to SCV. ); SifB (GEF, WxxxE family. ); SopD2 (Inhibits vesicle transport from the vacuole; down-modulates the formation of tubular structures. ); SpiC/ssaB (SsaL/ssaM/spiC regulatory complex, sensing host cell signals to activate effector secretion. ); SpvB (ADP-ribosyltransferase. Causes cytoskeletal disruption and apoptosis. ); SpvC; SpvD; SseF (Localizes to the phagosome, contributes to Sif formation; recruits dynein to SCV; maintains perinuclear SCV positioning; required for formation of microtubule bundles around SCV; redirects exocytic transport vesicles to SCV. ); SseG (Same as SseF. ); SseI/srfH (Blocks the migration of host immune cells by associating with host protein IQGAP1, an important regulator of cell migration; attenuates the host's ability to clear systemic bacteria. ); SseJ (Glycerophospholipid-cholesterol acyl transferase and deacylase. SseJ and SifA interact in a protein complex with SKIP and RhoA family GTPases as a mechanism to promote phagosome tubulation. ); SseK1; SseK2; SseL (Deubiquitinase. Required for Salmonella-induced delayed cytotoxicity of macrophages. ); SspH2 (Novel E3 ubiquitin-ligase. Specifically localizes to the brush border of polorized epithelial cells. ); SteC (Serine/Threonine kinase. Required for SPI-2 dependent F-actin remodelling. ) MPINRPNLNLNIPPLNIVAAYDGAEIPSTNKHLKNNFNSLHNQMRKMPVSHFKEALDVPDYSGMRQSGFFAMSQGFQLNNHGYDVFIHARRESPQSQGKFAGDKFHISVLRDMVPQAFQALSGLLFSEDSPVDKWKVTDMEKVVQQARVSLGAQFTLYIKPDQENSQYSASFLHKTRQFIECLESRLSENGVISGQCPESDVHPENWKYLSYRNELRSGRDGGEMQRQALREEPFYRLMTE Kraken2_NZ_CP065638.1 IMICODJL_19098 Prodigal:2.6 38129 38779 + VFG000437(gb|NP_490527) 100.0 1.38e-155 (spvD) Salmonella plasmid virulence: hydrophilic protein VF0947 TTSS-2 secreted effectors VFC0086 Effector delivery system GogB; PipB; PipB2 (Directly binds kinesin, a plus end-directed microtubule motor protein. Localizes to the phagosome; Promotes Sif extension, recuits kinesin-1 to SCV. ); SifA (GEF. Localizes to the cytosolic face of the SCV and binds to host protein-kinesin-binding protein SKIP to modulate phagosome tubulation; required for SCV membrane integrity and Sif formation; maintains perinuclear SCV positioning; redirects exocytic vesicles to SCV. ); SifB (GEF, WxxxE family. ); SopD2 (Inhibits vesicle transport from the vacuole; down-modulates the formation of tubular structures. ); SpiC/ssaB (SsaL/ssaM/spiC regulatory complex, sensing host cell signals to activate effector secretion. ); SpvB (ADP-ribosyltransferase. Causes cytoskeletal disruption and apoptosis. ); SpvC; SpvD; SseF (Localizes to the phagosome, contributes to Sif formation; recruits dynein to SCV; maintains perinuclear SCV positioning; required for formation of microtubule bundles around SCV; redirects exocytic transport vesicles to SCV. ); SseG (Same as SseF. ); SseI/srfH (Blocks the migration of host immune cells by associating with host protein IQGAP1, an important regulator of cell migration; attenuates the host's ability to clear systemic bacteria. ); SseJ (Glycerophospholipid-cholesterol acyl transferase and deacylase. SseJ and SifA interact in a protein complex with SKIP and RhoA family GTPases as a mechanism to promote phagosome tubulation. ); SseK1; SseK2; SseL (Deubiquitinase. Required for Salmonella-induced delayed cytotoxicity of macrophages. ); SspH2 (Novel E3 ubiquitin-ligase. Specifically localizes to the brush border of polorized epithelial cells. ); SteC (Serine/Threonine kinase. Required for SPI-2 dependent F-actin remodelling. ) MRVSGSASSQDIISRINSKNINNNDSNEVKRIKDALCIESKERILYPQNLSRDNLKQMARYVNNTYVHYSGNCVLLSACLHYNIHHRQDILSSKNTASPTVGLDSAIVDKIIFGHELNQSYCLNSIDEVEKEILNRYDIKRESSFIISAENYIAPIIGECRHDFNAVVICEYDKKPYVQFIDSWKTSNILPSLQEIKKHFSSSGEFYVRAYDEKHD Kraken2_NZ_CP065638.1 IMICODJL_19116 Prodigal:2.6 50382 50684 + VFG000436(gb|NP_490511) 100.0 1.7499999999999999e-68 (pefB) plasmid-encoded fimbriae regulatory protein PefB VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MMLNRKDADYYLGKEIMLARIRRGALIPAKVNEEHFWLLIGISSIHSEKIIQALRDYLVFGVSRKDVCERYEVNNGYFSTSLNRLSRISQAAAQMVVYYS Kraken2_NZ_CP065638.1 IMICODJL_19117 Prodigal:2.6 50959 51477 + VFG000435(gb|NP_490510) 100.0 5.8499999999999975e-115 (pefA) plasmid-encoded fimbriae major subunit PefA VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MKKSIIASIIALGVLGGTAHAANEVTFLGSVSATTCDLTTSVNGAAQPNQVVQLGTVQANQPGNFVDFAMKPVDPNAQGCANLAQKTATVSWASAALDGEGFGATSGTATDAKVLVESVNSKNPGAVNANASTVDFEGAKLTTDGLQFKAKLKGGATEGDFKSVASFAVAYK Kraken2_NZ_CP065638.1 IMICODJL_19118 Prodigal:2.6 51705 54113 + VFG000434(gb|NP_490509) 100.0 0.0 (pefC) plasmid-encoded fimbriae usher protein PefC VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MSFHHRVFKLSALSLALFSHLSFASTDSELNLDFLQGMSAIPSVLKSGSDFPAGQYYVDVIVNQENVGKARLSITPQEESANALCLSPEWLKAAGVPVRLEGYASTLNAAGQCYVLSRNPYTRVDFSYGSQSLVFSIPQSFLVGKTDPSRWDYGVPAARLKYSANASQTSGQSTSAYANADLMVNLGRWVLASNMSASRYADGSGEFTARDITLSTAISQVQGDLLLGKSQTRSALFSDFGFYGAALRSNSNMLPWEARGYAPLITGVANSTSRVTISQNGYAVYSKVVPPGPYQLDDVRSVGNGDLVVTVEDASGHKTTTVYPVTTLPTLLRPGEVEYNVAVGRKSSNYKLKKPFADGENGMFWMGSVGYGFDSTTLNAASILHGKYQAGGVSVTQALGGFGAVSAGMNLSQAKYDNGDNKRGHSVSAKYAKSFSDSSDLQLLAYRYQSKGYVEFADFYSTDRYTRYNTKSRYEMRFSQRLGNSNLNLAGWQEDYWWMKGKAIGGDVSLSTTILDGVSVFLNGSYSKRPYLDKPDYSTSLSFSIPFTLGGVRHYSSTGLSYSSSGRMGMNSGVSASPTDRLSYGLNTNLSDKGDRSLSGNLSYGFDAIQTNMMLSQGRDNTTVSGSVSGTILGTADSGLMMTKETGNTLGVARIPGVKGVRINGSAPTNSKGYTVVNLSDYSLNRVSVDMENVPDDLELQTTSFNVVPTEKAVVYREFGAEHVLRYILRVKERDGRILNGGSAQTEQGLDAGFIAGNGVLLMNMLSAPSRVSVERGDGSVCHFSVKGIVPNTGKVQEVYCE Kraken2_NZ_CP065638.1 IMICODJL_19119 Prodigal:2.6 54106 54798 + VFG000433(gb|NP_490508) 100.0 8.61e-166 (pefD) plasmid-encoded fimbriae chaperone protein PefD VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MNKMMKWGLVSLLSLAVSGQAMAAFVLNGTRFIYEEGRKNTSFEVTNQADETFGGQVWIDNTTQGSSTVYMVPAPPFFKVRPKEKQIIRIMKTDSTLPSDRESLFWLNVQEIPPKPKASEGNVLAVAVNTKVKLIYRPKALVEGRRNAEKNLQIAHRGGEAYLKNPTPYYFAVTGVKLNGQPVRLNDRVMNEIAQLAPKSEVALGKLSLNGTVTVQAVNDWGGTQDYTLK Kraken2_NZ_CP065638.1 IMICODJL_19128 Prodigal:2.6 59497 60054 + VFG000442(gb|NP_490501) 100.0 1.2600000000000001e-129 (rck) resistance to complement killing VF0108 Rck Resistance to complement killing VFC0258 Immune modulation Rck belongs to a family of five homologous OMP proteins characterized in Salmonella (Rck and PagC), Escherichia coli (Lom), Yersinia enterocolitica (Ail) and Enterobacter cloacae (OmpX) Rck is predicted to be an eight-stranded beta-barrel protein that resides in the outer membrane Confers serum resistance by binding human complement factor H.; Rck mediates cell invasion through a Zipper-like mechanism, as described for other bacteria such as Listeria and Yersinia. Salmonella seems to be the first bacterium found to be able to induce both Zipper-like mechanism and the Trigger mechanism mediated by its T3SS-1 apparatus. MKKIVLSSLLLSAAGLAAVPVAQADTHSVSVGYAQSRIEHFKDIRGVNLKYRYEAQTPLGLMASFSWQSGKRGESGGIPGGMSWRDDVKATYWSLMAGPAVRVNELVSLYALAGAGTGRAEVKERISMPGYNGRFTGSERRTGFAWGAGVQFNPVENVVIDLGYEGSKVGAAKLNGVNVGVGYRF Kraken2_NZ_CP018064.1 IMICODJL_19259 Prodigal:2.6 41279 42274 + VFG006022(gb|WP_002947383) 61.8 2.46e-164 (rfbB) dTDP-glucose 4,6-dehydratase VF0144 Capsule VFC0258 Immune modulation Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages Resistant to complement deposition and masks cell wall-associated complement from being recognized by the complement receptors on phagocytes MRLLVTGGAGFIGANFVHQTVAERPDVRVTVLDALTYAGTKSSLDAVADKIHFIHGDIADADVVNRLVADADAVVHFAAESHNDNSLADPWPFVRTNVVGTFTLLQAVRDYDVRYHHISTDEVYGDLDLHDPARFTESTAYNPSSPYSSTKASSDMLVRAWTRSFGIRATLSNCSNNYGPFQHVEKFIPRQITNLLDGVRPKLYGQGRNVRDWIHVDDHNRAVWTVLEKGRIGETYLIGADGEVDNRTVIAMLLEIFGRSADDFDFVPDRPGHDLRYAIDSTRLRTELGWEPRYRDFRSGLEATVQWYREHPEWWRPAKAATEAGYARTGQ Kraken2_NC_008759.1 IMICODJL_20165 Prodigal:2.6 28880 29233 - VFG044400(gb|AAF33141) 62.8 2.31e-13 (pdtorfQ) PdtorfQ VF0938 Pyridine-2,6-dithiocarboxylic acid (PDTC) VFC0272 Nutritional/Metabolic factor MANAPLIDVSCLEAALQKFADERDWQQYHSPKNLAMALSAEVGELVEIFQWQTEEQSKLVAKDEATAQAVRDELADVLLYLVRLSSVLGVDLNEAVAQKLVKNVSKYPAGDSTPSRP Kraken2_NC_008760.1 IMICODJL_20346 Prodigal:2.6 37863 38474 - VFG014116(gb|NP_251832) 61.0 8.28e-25 (PA3142) hypothetical protein VF0085 LPS VFC0258 Immune modulation Two distinct forms of LPS: A-band and B-band. A-band is a homopolymer of alpha-linked D-rhamnose, whereas B-band LPS is a heteropolymer Mediates biological effects including resistance to serum killing and phagocytosis; the binding to normal CFTR (cystic fibrosis transmembrane conductance regulator) and invasion of host cells may make a contribution to virulence in the human eye; internalization by binding to normal CFTR protein expressed by airway epithelial cells followed by desquamation of bacteria-laden epithelial cells, constitutes a host defense mechanism. If this mechanism fails to function properly, abnormally high bacterial carriage would promote the establishment of chronic bacterial infection Binding interaction occurs between the first extracellular loop of CFTR (predicted to be in amino acids 108-117 of the mature protein) and the complete outer portion of the core polysaccharide of the LPS MVIKHHFPERRACRLVGLSRDSYRHPPKADQATLDLQEKIVEIAHVRRRFGYRRIHDLLRPQFPGVNHKRVYRLYCEADLAVRRRKKAKRPVNERVPLQLARTVNEVWSMDFVSDSLSSGRRLKYLTVADDFSHESVDIAVDFGISGQYVTRVLDQAARFRGYPQAVRTDNGPEFTSRAFMAWVHRGVERHAWPDQCPEDQFP Kraken2_NC_012473.1 IMICODJL_21045 Prodigal:2.6 87096 88289 + VFG000682(gb|AAF13663) 97.2 6.5e-284 (capB) CapB, involved in Poly-gamma-glutamate synthesis VF0141 Capsule VFC0258 Immune modulation Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 A polymer of gamma-D-glutamic acid Inhibits phagocytosis, and it is a monotonous linear polymer that is only very weakly immunogenic that enables the bacteria to evade the host-immune defenses and facilitate systemic invasion and dissemination within the bloodstream; produces a concentration dependent enhancement of the cytotoxicity of LT through an enhancement in the binding and accumulation of protective antigen to its receptors. MVFIIGICTVFLIIYGIWEQRCHQKRLNSIPIRVNVNGIRGKSTVTRLITGVVQEAKYKTVGKTTGTSARMIYWFTDEEQPIKRRKEGPNIGEQRRVVKEVADLEAEALICECMAVQPDYQIIFQNKMIQANVGVIVNVLEDHMDVMGPTLDEVAEAFTATIPYNGHLVTMESEYLDYFKKVAEERNTKVIVADNSRISEEFLRKFDYMVFPDNASLALAVAEALGIDEETAFRGMLNAHPDPGAMRITRFGDQSKPAFFVNGFAANDPSSTLRIWERVDEFGYSNLAPIVIMNCRPDRVDRTEQFARDVLPYIKAEIVIAIGETTAPITSAFEKGDIPTQEYWNLEGWSTSEIMSRMRPYLKDRIVFGVGNIHGAAEPLIKMIMEEQIGKKQAKAI Kraken2_NC_012473.1 IMICODJL_21046 Prodigal:2.6 88304 88753 + VFG050057(gb|WP_000468006) 95.3 2.69e-93 (capC) CapC, involved in Poly-gamma-glutamate synthesis VF0141 Capsule VFC0258 Immune modulation Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 A polymer of gamma-D-glutamic acid Inhibits phagocytosis, and it is a monotonous linear polymer that is only very weakly immunogenic that enables the bacteria to evade the host-immune defenses and facilitate systemic invasion and dissemination within the bloodstream; produces a concentration dependent enhancement of the cytotoxicity of LT through an enhancement in the binding and accumulation of protective antigen to its receptors. MFGSDLYIALVLGVTLSLIFTEKTGVLPAGLVVPGYLALVFNQPVFMLVVLFISILTYVIVTYGVSRFMILYGRRKFAAMLITGICLKLLFDYFYPVMPFEILEFRGIGVIVPGLIANTIQRQGLPLTIGTTILLSGLTFAIMKVYYLF Kraken2_NC_012473.1 IMICODJL_21047 Prodigal:2.6 88765 90003 + VFG000680(gb|AAF13661) 92.1 1.04e-264 (capA) CapA, required for Poly-gamma-glutamate transport VF0141 Capsule VFC0258 Immune modulation Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 A polymer of gamma-D-glutamic acid Inhibits phagocytosis, and it is a monotonous linear polymer that is only very weakly immunogenic that enables the bacteria to evade the host-immune defenses and facilitate systemic invasion and dissemination within the bloodstream; produces a concentration dependent enhancement of the cytotoxicity of LT through an enhancement in the binding and accumulation of protective antigen to its receptors. MRRKLTFQEKLLIFIKKTKKKNTRYVTIALPLIAVILIAVTWVQRTEAVAPVKHRENEKLTMTMVGDVMMGRNVKKIVDRYGTDYIFRHVSPYLKNSDYVSGNFAHPVLLEDKKNYQKANKNIHLSVKEDAVKAVKEAGFTVLNLANNHMTDYGAKGTLDTLKAFKEAELDYVGAGKNFRDVKNIVYQNVNGVRVATLGFTDVFVAGSIATKEQPGTLSMNPDVLFKQISKAKDPKKGNADLVVVNTHWGQEYDNKPSPRQEALAKAMVDAGADIIVGHHPHVLQSFDVYKQGIIFYSLGNFVFDQGWTSTKDSALVQYHLRDNGTATLDVVPLNIQEGTPKPVTGALDKDRVYRQLTKDTSRGALWSKKGDKLEIKLNHKHVIEKMKKREERQNKQEKENKGDKASEETTT Kraken2_NC_012473.1 IMICODJL_21048 Prodigal:2.6 90000 91586 + VFG050059(gb|WP_013245291) 91.7 0.0 (dep/capD) gamma-glutamyltranspeptidase, required for polyglutamate anchoring to peptidoglycan VF0141 Capsule VFC0258 Immune modulation Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 A polymer of gamma-D-glutamic acid Inhibits phagocytosis, and it is a monotonous linear polymer that is only very weakly immunogenic that enables the bacteria to evade the host-immune defenses and facilitate systemic invasion and dissemination within the bloodstream; produces a concentration dependent enhancement of the cytotoxicity of LT through an enhancement in the binding and accumulation of protective antigen to its receptors. MKSFEWGKKIILSCLIVSLMGCIGASCSFNKIKDSVKQKIDSMGDKGTYGVSASHPLAVEEGMKVLKNGGSAVDAAIVVSYVLGVVEPHASGIGGGGGMLIISKDKKTFIDYRETTPYFTGNKNLPIGVPGFVAGMEYIHDTYGSLPMGELLQPAINYAEKGFKVDDTLTMQLKLEKPRIYSDKLSIFYPNGEPIETGETLIQAELARTLKKIQKEGDKGFYKGKVARAISKTAKISLEDIEGYKVEVRKPVKGNYMGYDVYTAPPPFSGVTLLQMLKLAEEKKVYKDVDHTATYISKMEEITRVAYQDRKENIGDPNYVNMDPNKMVSDKYISTIKNENGEALSEEEHESTTHFVIIDRDGTVVSSTNTLSNFFGTGKYTAGFFLNNQLQNFGSEGINNYEPGKLSRTFMAPTVLKKDGETIGIGSPGGNRIPQILTPILDKYTHGKGSLQDIVNEHRFAFGKNTAYIEMQLSPEVKNELSRKGLNVKQKASPTFFGGVQALIKDERDNVITGAGDDRRNGTWKSNK Kraken2_NC_012473.1 IMICODJL_21049 Prodigal:2.6 91601 91744 + VFG016306(gb|WP_000239644) 80.9 4.2400000000000005e-21 (capE) CapE, involved in Poly-gamma-glutamate synthesis VF0141 Capsule VFC0258 Immune modulation Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 A polymer of gamma-D-glutamic acid Inhibits phagocytosis, and it is a monotonous linear polymer that is only very weakly immunogenic that enables the bacteria to evade the host-immune defenses and facilitate systemic invasion and dissemination within the bloodstream; produces a concentration dependent enhancement of the cytotoxicity of LT through an enhancement in the binding and accumulation of protective antigen to its receptors. MAKRVFGWIIPIFIVGALLVTMETFKRSETLTTDEQKKINDYQQTNP Kraken2_NC_012473.1 IMICODJL_21056 Prodigal:2.6 99716 101737 + VFG050047(gb|WP_012680378) 100.0 1.3e-257 (bslA) s-layer protein VF0411 BslA B. anthracis S-layer protein A VFC0001 Adherence "Consists of a canonical Ig-like domain, to which is appended a three-stranded ""cap"" that is highly hydrophobic in character, rich in leucine residues as well as isoleucine, valine, and alanine. This cap comprises a surface-exposed hydrophobic patch." Encodes a major S-layer protein that is located within the pXO1 pathogenicity island that also codes for toxin genes. BslA mediates adherence and entry to epithelial cells by binding integrin alpha2beta1 and complement component C1q;forms a highly hydrophobic coat around B. subtilis biofilms MKKRKIKAITSFTLIGSILFGGNINSTQAESDLKKIVPDQMVPAFLDVPSNHWANVAINNLLKKEIIVGYGNNKFGLGDSVTREQVAAVIYRIKFPEKEVEAEAQNPYRDVNKSSTMFLDEILTLTKMGIFSGDEKGNFRPKSPISRAEMTQVIKNAFNIPVVGKHNFRDVAKDYWANDAISALQSNQLVSGTGNGLFEPYKSVTREEYAQFIFNVLNFEDLVNKEKQLDELNKRRDVINQKIDEFDKLNSQRKDLERMLEELNQKLSQLKQQSPQLQDLKNKLKESQSRLLELNKKDSNRLELNSEIKKLNDRKAELLSLIMELIKQQSEFDKKIKNEKDDLNKKREDLINRIAESKELAKKKAELNTKLVELFKVQEALNKKSGQYLYYINKLDNELRELADKYKNSDNKISRLKNHIGEYNKQLEKIENELEECNKKIDNTKKQLAEFDKSNKKQQELESELVQLNKKIDELGKRHKHRQELEASQKKALDEAKEINKKLAEKDPERQHINDKLKKLNNDWRLTNNELNRLNSELQKVNTKLLGYSQEHQYYNALNKERTELSKKVDEIYQKQSEIDKNYIELNRQLDELSNPKPNEQVQLLKNQINELNSSINQILNHRKNEINNITQRKDHIIDQLNQFPKLNLEYQTVKNELNVIDQEIGKLVQSKA Kraken2_NC_012473.1 IMICODJL_21059 Prodigal:2.6 104028 105425 + VFG050171(gb|WP_033691404) 100.0 5.95e-307 (hasA) hyaluronan synthase VF0667 Hyaluronic acid (HA) capsule VFC0258 Immune modulation MKNFFINIKPYTSYEKFRSYLPKGENSLKQNKIKSSLKMPFILLVFSLLIVAMYYINFTIRGSFSLFLGIYGTLMVIYLLGKQSLSFFYRPITGDKVPNMKVAVVVPSYNESASAIVNTINSVLAQDYPIHEIFFVDDGSKDKSAYEVALKMREELLRTQREIAATTKNNCSEILGIPDLIVHRLPKNCGKRHAQLWAFKRTTADAIVTIDSDGDLFPNAVRELLKPFNDEKVMATTGHVNIRNRNDNLLTKLIDMRYDNAFRVERAAQSVTGNVLVCSGPLSCYRREVITENLEHYGSQMFLGEEVQFGDDRCLTNYAILKGKTVYQSTARCITDAPTTLKQFLKQQLRWNKSFFRESLISLGIGMKKPNVLVWTIFEISLWILFGLSLLLSIILKASHVGLILAVYYLGYISLAAYARNVFYLLKHPLTFLLAPLYGILHVLALLPIRFYALLTIKSNGWGTR Kraken2_NC_012473.1 IMICODJL_21060 Prodigal:2.6 105468 106355 + VFG050173(gb|WP_000702222) 100.0 6.15e-212 (hasC) UTP--glucose-1-phosphate uridylyltransferase VF0667 Hyaluronic acid (HA) capsule VFC0258 Immune modulation MKIRKAIIPAAGLGTRFLPATKAQPKEMLPIVDKPTIQYIVEEAVSSGIEDIIIVSGRGKHVIEDHFDKSYELEQTLFKKNKIKTLEDIECISNLANIHYIRQKEPKGLGHAIYCARRFIGEEPFAVLLGDDIVSSTYPCLKQLIDVYEEHHCSVVGVQRVLETEVSKYGIVKSANQNVNQSIIPISMLVEKPPLETAPSNLAIMGRYILKPDIFEVLKNLPVGSGGEIQLTDAINVLNKQQKVLAFEFDGKRYDVGDKFGFIKATIDFALQRESLKEDVLSYLRNITRDKLINK Kraken2_NC_012473.1 IMICODJL_21061 Prodigal:2.6 106382 107713 + VFG050177(gb|WP_001027044) 100.0 5.93e-319 (hasB) UDP-glucose dehydrogenase VF0667 Hyaluronic acid (HA) capsule VFC0258 Immune modulation MNISIVGTGYVGLVTGVCLSEVGHNVTCIDIDEEKVKKMKLGYSPIFEPCLEELMKNNIIKGRLHFTTNYVDGADGAEIFYIAVGTPQKEDGSADLSFIKQAAINIARTIKNDVIIVVKSTVPVGTNIYIKNLILKNLNYDVKVDIISNPEFLREGSAVNDTFYGDRIVIGSENKTSANVMEEVYKPFGTPIFKTDIQSAEMIKYASNTFLATKISFINGIANLCEMVGADVEKVAQGMGQDKRIGSQFLNAGIGYGGSCFPKDTHALVKVSESLQHKFHLLESVIKLNKNQQTVLIEKIKKRFGSIVGKKIALLGLSFKPNTDDLREAPSIPIARKLVEEGAQVIAYDPVAIKNAREVLPKEVHYVYSTMEALTEADIALVLTEWDEVVDSLLLKASQLMKEPVIFDGRNCFELNEAKNYDVEYHSIGRPSVLREVKGEITA Kraken2_NC_012473.1 IMICODJL_21071 Prodigal:2.6 115514 117916 + VFG050085(gb|WP_000197746) 99.9 0.0 (cya) calmodulin sensitive adenylate cyclase, edema factor VF0142 Anthrax toxin VFC0235 Exotoxin AtxA, a pXO1 gene required for transcription of the three toxin genes, also positively regulated encapsulation; the expression of atxA gene is not controlled by CO2 Belongs to the family of bacterial AB toxins:; Composed of a single B subunit called protective antigen (PA) and two alternative A subunits: edema factor (EF) and lethal factor (LF); Monomeric PA displays four structural domains:; Domain 1 contains the proteolytic activation site. Domain 2 is a beta-barrel core containing a large flexible loop for pore formation. Domain 3 is involved in heptamer formation. Domain 4 binds to anthrax toxin receptor (ATR); LF is organized into four domains:; Domain 1 (LFn) is the PA-binding domain. Domain 2 (VIP2-like, VIP2, an ADP-ribosylating toxin from Bacillus cereus) participates in forming a binding pocket for substrate peptide. Domain 3 is a helical bundle that may contribute to substrate specificity by restricting access to the binding pocket. Domain 4 is the catalytic center; PDB code for PA: 1ACC, LF: 1J7N, EF: 1K8T, 1K93, 1K90 The combination of PA and EF is edema toxin (EdTx), the combination of PA and LF is lethal toxin (LeTx); EF is a calcium- and calmodulin-dependent adenylate cyclase that causes dramatic increases in intracellular concentrations of cAMP; LF is a zinc-dependent protease that cleaves mitogen-activated protein kinase kinases (MAPKKs) in their amino-terminal regions. It is a multi-functional virulence factor that appears to play a role in all stages of infection. Early in the infection, it acts to suppress immune cell and cytokine responses, thereby promoting bacterial outgrowth. Later in the disease, it induces the cytokine-independent shock-like death associated with anthrax. PA, EF and LF are secreted independently and assemble at the mammalian cell surface into toxin complexes. PA binds to cell-surface anthrax toxin receptor (ATR), encoded by the tumor endothelial marker 8 (TEM8) gene. ATR is a type I membrane protein with an extracellular von Willebrand factor type A domain (VWA) and is cleaved by furin or a furin-like protease, releases an amino-terminal 20kDa fragment (PA20) and the receptor-bound carboxy-terminal 63kDa fragment (PA63). Recently, a second PA receptor encoded by capillary morphogenesis gene 2 (CMG2) has been identified. It has 60% amino acid identity to ATR/TEM8 within the VWA/I domain, as well as a conserved MIDAS (metal ion dependent adhesion site) motif; PA63 oligomerizes into ring-shaped hepameric or actameric pre-channels and binds 3 or 4 LF/EF substrates respectively. The assembled toxic complexes are then internalized by membrane lipid rafts and directed to endosomes. The PA oligomer transforms into a transmembrane, beta-barrel channel. The proton motive force unfolds and translocates LF and EF through the channel. Once the enzymatic moieties have accessed the cytosolic compartment, they exert their toxic activities. MTRNKFIPNKFSIISFSVLLFAISSSQAIEVNAMNEHYTESDIKRNHKTEKNKTEKEKFKDSINNLVKTEFTNETLDKIQQTQDLLKKIPKDVLEIYSELGGEIYFTDIDLVEHKELQDLSEEEKNSMNSRGEKVPFASRFVFEKKRETPKLIINIKDYAINSEQSKEVYYEIGKGISLDIISKDKSLDPEFLNLIKSLSDDSDSSDLLFSQKFKEKLELNNKSIDINFIKENLTEFQHAFSLAFSYYFAPDHRTVLELYAPDMFEYMNKLEKGGFEEISESLKKEGVEKDRIDVLKGEKALKASGLVPEHADAFKKTARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKKESAKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKEMITNQVQLLLTHQKSNIEFKLLYKQLNFTENETDKFEVFQKIIDEK Kraken2_NC_012473.1 IMICODJL_21076 Prodigal:2.6 120671 122098 - VFG002040(gb|AAD32423) 100.0 0.0 (AAD32423) pXO1-119 VF0332 AtxA Anthrax toxin activator VFC0301 Regulation A master regulator: it enhances not only the transcription of all three toxin genes, but also that of the cap operon MLTPISIEKEHIRLINLLHFINEQNRWFTIKELSDYLQVADKTVRKYLKLLEDEIPPSWNLLVQKGKGIYLKKPLNESLSFVESKILRKSLNLQICEELVFKKNSMQSLAQKLHLQVGALYPIINQINYDIQSSHLNIKKKPLEISGREQDVRVFMLRLYCNIPNDYWPFPYINKQNITDLINKMEKILNVQMYTYSKHKLCVLFAITISRLLSGNTIDNVSGLILVNKNDDHYKTVASITSELQNSFGVTLHETEISFLALALLLSLGNSITTDSNKTLTSYKKTIMPLAKEITKGIEHKLQLGINYDESFLTYVVLIIKKALDKNFIQYYNYNIKFIRHIKQRHPNTFNTIQECISNLNYTVYSHFDCYEISLLTMHFETQRMLFKNNPKKIYVYTSQGCIHREYISALLEKRYNGLIKIVRNTIINLTNESLQDMEIDIIISNVNLPIKNIPIVQISEFPTERDFHEIKKII Kraken2_NC_012473.1 IMICODJL_21084 Prodigal:2.6 128345 130639 + VFG050081(gb|WP_000746484) 89.0 0.0 (pagA) anthrax toxin moiety, protective antigen VF0142 Anthrax toxin VFC0235 Exotoxin AtxA, a pXO1 gene required for transcription of the three toxin genes, also positively regulated encapsulation; the expression of atxA gene is not controlled by CO2 Belongs to the family of bacterial AB toxins:; Composed of a single B subunit called protective antigen (PA) and two alternative A subunits: edema factor (EF) and lethal factor (LF); Monomeric PA displays four structural domains:; Domain 1 contains the proteolytic activation site. Domain 2 is a beta-barrel core containing a large flexible loop for pore formation. Domain 3 is involved in heptamer formation. Domain 4 binds to anthrax toxin receptor (ATR); LF is organized into four domains:; Domain 1 (LFn) is the PA-binding domain. Domain 2 (VIP2-like, VIP2, an ADP-ribosylating toxin from Bacillus cereus) participates in forming a binding pocket for substrate peptide. Domain 3 is a helical bundle that may contribute to substrate specificity by restricting access to the binding pocket. Domain 4 is the catalytic center; PDB code for PA: 1ACC, LF: 1J7N, EF: 1K8T, 1K93, 1K90 The combination of PA and EF is edema toxin (EdTx), the combination of PA and LF is lethal toxin (LeTx); EF is a calcium- and calmodulin-dependent adenylate cyclase that causes dramatic increases in intracellular concentrations of cAMP; LF is a zinc-dependent protease that cleaves mitogen-activated protein kinase kinases (MAPKKs) in their amino-terminal regions. It is a multi-functional virulence factor that appears to play a role in all stages of infection. Early in the infection, it acts to suppress immune cell and cytokine responses, thereby promoting bacterial outgrowth. Later in the disease, it induces the cytokine-independent shock-like death associated with anthrax. PA, EF and LF are secreted independently and assemble at the mammalian cell surface into toxin complexes. PA binds to cell-surface anthrax toxin receptor (ATR), encoded by the tumor endothelial marker 8 (TEM8) gene. ATR is a type I membrane protein with an extracellular von Willebrand factor type A domain (VWA) and is cleaved by furin or a furin-like protease, releases an amino-terminal 20kDa fragment (PA20) and the receptor-bound carboxy-terminal 63kDa fragment (PA63). Recently, a second PA receptor encoded by capillary morphogenesis gene 2 (CMG2) has been identified. It has 60% amino acid identity to ATR/TEM8 within the VWA/I domain, as well as a conserved MIDAS (metal ion dependent adhesion site) motif; PA63 oligomerizes into ring-shaped hepameric or actameric pre-channels and binds 3 or 4 LF/EF substrates respectively. The assembled toxic complexes are then internalized by membrane lipid rafts and directed to endosomes. The PA oligomer transforms into a transmembrane, beta-barrel channel. The proton motive force unfolds and translocates LF and EF through the channel. Once the enzymatic moieties have accessed the cytosolic compartment, they exert their toxic activities. MKKRKALIPLMALSTILVSNTGNLDTIQAEVKQENQLLNESESSSQGLLGYYFSDLNFQAPMVITPSTTGDLSIPSSELENIPSEKQYFQSAIWSGFIKVEKSDEYTFATSNDSHVTMWVDNQEVINKSSNYNKIRLEEGQLYPIKIQYQRENPTEKGLDFQLYRTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAESTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPSVHVDMENIIVSKNTDSSIQQGASQGQTISKSTSTSRTHTSEVHGDVEVHASLFDIGGSISAGFSNSNSSTVAIDHSQSIAGETTWAETIGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQMLAPNNYYPSKNLAPIALNAQDDFSSTPITVNYNQFLELEETKQLRLDTDQVYGNIATYNSINGSVTVDTGSNWSDVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDALEMTKPDMTLKEALKIAFGFNEQNGDLRYQGKNITEFDFNFDQQTSQNIKNQLAELNATNIYSVLDKIQLNAKMNILIRDKRFHYDRNNIAVGADESVIKEAHREVINSSREGLSLNIDKDIRKVISGYIVEIEYDKGDKGILNDRYDMLNIYNVQQDGKTFIDFKKYNDKLPLYLSNPNDKVNVYAVTKENHIINPREDADIGISEIKKTLIFSKKAYEIG Kraken2_NC_012473.1 IMICODJL_21085 Prodigal:2.6 131660 131959 + VFG050075(gb|WP_000215714) 86.9 2.7100000000000002e-58 (pagR-XO1) transcriptional repressor PagR VF0664 PagR-XO1 VFC0301 Regulation MTLFVDHKIEYMSFEEEADFLKTMAHPMRLKLVNELYKHKALNVTQITQILKLPQSTVSQHLSKMRGKVLKGNRQGLEIYYSINNPKVEAIIELLSPIR Kraken2_NC_012473.1 IMICODJL_21087 Prodigal:2.6 136777 139071 + VFG050081(gb|WP_000746484) 99.6 0.0 (pagA) anthrax toxin moiety, protective antigen VF0142 Anthrax toxin VFC0235 Exotoxin AtxA, a pXO1 gene required for transcription of the three toxin genes, also positively regulated encapsulation; the expression of atxA gene is not controlled by CO2 Belongs to the family of bacterial AB toxins:; Composed of a single B subunit called protective antigen (PA) and two alternative A subunits: edema factor (EF) and lethal factor (LF); Monomeric PA displays four structural domains:; Domain 1 contains the proteolytic activation site. Domain 2 is a beta-barrel core containing a large flexible loop for pore formation. Domain 3 is involved in heptamer formation. Domain 4 binds to anthrax toxin receptor (ATR); LF is organized into four domains:; Domain 1 (LFn) is the PA-binding domain. Domain 2 (VIP2-like, VIP2, an ADP-ribosylating toxin from Bacillus cereus) participates in forming a binding pocket for substrate peptide. Domain 3 is a helical bundle that may contribute to substrate specificity by restricting access to the binding pocket. Domain 4 is the catalytic center; PDB code for PA: 1ACC, LF: 1J7N, EF: 1K8T, 1K93, 1K90 The combination of PA and EF is edema toxin (EdTx), the combination of PA and LF is lethal toxin (LeTx); EF is a calcium- and calmodulin-dependent adenylate cyclase that causes dramatic increases in intracellular concentrations of cAMP; LF is a zinc-dependent protease that cleaves mitogen-activated protein kinase kinases (MAPKKs) in their amino-terminal regions. It is a multi-functional virulence factor that appears to play a role in all stages of infection. Early in the infection, it acts to suppress immune cell and cytokine responses, thereby promoting bacterial outgrowth. Later in the disease, it induces the cytokine-independent shock-like death associated with anthrax. PA, EF and LF are secreted independently and assemble at the mammalian cell surface into toxin complexes. PA binds to cell-surface anthrax toxin receptor (ATR), encoded by the tumor endothelial marker 8 (TEM8) gene. ATR is a type I membrane protein with an extracellular von Willebrand factor type A domain (VWA) and is cleaved by furin or a furin-like protease, releases an amino-terminal 20kDa fragment (PA20) and the receptor-bound carboxy-terminal 63kDa fragment (PA63). Recently, a second PA receptor encoded by capillary morphogenesis gene 2 (CMG2) has been identified. It has 60% amino acid identity to ATR/TEM8 within the VWA/I domain, as well as a conserved MIDAS (metal ion dependent adhesion site) motif; PA63 oligomerizes into ring-shaped hepameric or actameric pre-channels and binds 3 or 4 LF/EF substrates respectively. The assembled toxic complexes are then internalized by membrane lipid rafts and directed to endosomes. The PA oligomer transforms into a transmembrane, beta-barrel channel. The proton motive force unfolds and translocates LF and EF through the channel. Once the enzymatic moieties have accessed the cytosolic compartment, they exert their toxic activities. MKKRKALIPLMALSTILVSNTGNLEVIQAEVTQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTPSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPSVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNVTNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG Kraken2_NC_012473.1 IMICODJL_21088 Prodigal:2.6 139994 140293 + VFG050075(gb|WP_000215714) 100.0 6.619999999999999e-68 (pagR-XO1) transcriptional repressor PagR VF0664 PagR-XO1 VFC0301 Regulation MTVFVDHKIEYMSLEDDAELLKTMAHPMRLKIVNELYKHKALNVTQIIQILKLPQSTVSQHLCKMRGKVLKGNRQGLEIYYSINNPKVEGIIKLLNPIQ Kraken2_NC_012473.1 IMICODJL_21091 Prodigal:2.6 142357 144786 - VFG016210(gb|WP_001022097) 98.9 0.0 (lef) anthrax toxin lethal factor precursor VF0142 Anthrax toxin VFC0235 Exotoxin AtxA, a pXO1 gene required for transcription of the three toxin genes, also positively regulated encapsulation; the expression of atxA gene is not controlled by CO2 Belongs to the family of bacterial AB toxins:; Composed of a single B subunit called protective antigen (PA) and two alternative A subunits: edema factor (EF) and lethal factor (LF); Monomeric PA displays four structural domains:; Domain 1 contains the proteolytic activation site. Domain 2 is a beta-barrel core containing a large flexible loop for pore formation. Domain 3 is involved in heptamer formation. Domain 4 binds to anthrax toxin receptor (ATR); LF is organized into four domains:; Domain 1 (LFn) is the PA-binding domain. Domain 2 (VIP2-like, VIP2, an ADP-ribosylating toxin from Bacillus cereus) participates in forming a binding pocket for substrate peptide. Domain 3 is a helical bundle that may contribute to substrate specificity by restricting access to the binding pocket. Domain 4 is the catalytic center; PDB code for PA: 1ACC, LF: 1J7N, EF: 1K8T, 1K93, 1K90 The combination of PA and EF is edema toxin (EdTx), the combination of PA and LF is lethal toxin (LeTx); EF is a calcium- and calmodulin-dependent adenylate cyclase that causes dramatic increases in intracellular concentrations of cAMP; LF is a zinc-dependent protease that cleaves mitogen-activated protein kinase kinases (MAPKKs) in their amino-terminal regions. It is a multi-functional virulence factor that appears to play a role in all stages of infection. Early in the infection, it acts to suppress immune cell and cytokine responses, thereby promoting bacterial outgrowth. Later in the disease, it induces the cytokine-independent shock-like death associated with anthrax. PA, EF and LF are secreted independently and assemble at the mammalian cell surface into toxin complexes. PA binds to cell-surface anthrax toxin receptor (ATR), encoded by the tumor endothelial marker 8 (TEM8) gene. ATR is a type I membrane protein with an extracellular von Willebrand factor type A domain (VWA) and is cleaved by furin or a furin-like protease, releases an amino-terminal 20kDa fragment (PA20) and the receptor-bound carboxy-terminal 63kDa fragment (PA63). Recently, a second PA receptor encoded by capillary morphogenesis gene 2 (CMG2) has been identified. It has 60% amino acid identity to ATR/TEM8 within the VWA/I domain, as well as a conserved MIDAS (metal ion dependent adhesion site) motif; PA63 oligomerizes into ring-shaped hepameric or actameric pre-channels and binds 3 or 4 LF/EF substrates respectively. The assembled toxic complexes are then internalized by membrane lipid rafts and directed to endosomes. The PA oligomer transforms into a transmembrane, beta-barrel channel. The proton motive force unfolds and translocates LF and EF through the channel. Once the enzymatic moieties have accessed the cytosolic compartment, they exert their toxic activities. MNIKKEFIKVISMSCLVTAITLSGPVFIPLVQGAGGHGDVGMHVKEKEKNKDENKRKDEERNKTQEEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKAIGGKIYIVDGDITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYEPVLVIQSSEDYVENTEKALNVYYEIGKILSRDILSKINQPYQKFLDVLNTIKNASDSDGQDLLFTNQLKEHPTDFSVEFLEQNSNEVQEVFAKAFAYYIEPQHRDVLQLYAPEAFNYMDKFNEQEINLSLEELKDQRMMARYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEETELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEEEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTQAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNINQEWNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNGRFVFTDITLPNIAEQYTHQDKIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHEFGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEAFRLMHSTDHAERLKVQKNAPKTFQFINDQIKFIINS Kraken2_NC_012473.1 IMICODJL_21127 Prodigal:2.6 172928 173221 - VFG050076(gb|WP_001971534) 60.0 2.11e-27 (pagR-XO1) metalloregulator ArsR/SmtB family transcription factor VF0664 PagR-XO1 VFC0301 Regulation MTTIQASNEMHKIPEADVELLKIMAHPVRLQIVKELEHRKICNVTQLTELLDIPQSTVSQHLSKMRGKILRSERRGLEMYYHIVNSKACQIVSVLGL Kraken2_NC_012577.1 IMICODJL_21191 Prodigal:2.6 47348 48796 - VFG049939(gb|WP_000409765) 99.8 0.0 (acpB) capsule synthesis positive regulator AcpB VF0666 AcpAB VFC0301 Regulation MEKDIKRQIQILEIITSEEKWFTTIEISKILRCCNKTIMKDISFIKDFLPEDWHIKIKKGKGVRIYLPYNKHRNEITFLLFRESLTFRILQHLFERETKTIATLAERLYIQVPSILPALKRVENYLKKFGLKLRKKPLRLEGDEVRIMIMYLDLYLKSYNDTEWPFEKLKKEVIFQYLGTLEESLGISLHVVSKRHLSFFIAILLKRKQQGYKVQLNRKFLYFNTETPDYVKIGRIFEKLEREFGVSLTVQDKILLTISIKSSKYVYKDINKEKEESVQYFKEGNLSIYELVKDFINSLEEKLKVDLISDEEFIFALVDYFKRTIYHLQYLCMFERPQKQTIQYMQTEHSETFSAVKEVYTEFVKKNEIADYVSVEEIAKVTMYIEASRLRYTSNYKKVLLVTGESESWAEYLAATLAKRFGDKIQISTVFFAKKSDHDVNADFIISTIPLDLGSTPIICVNSIPTERDYTNIQYYLDLQDG Kraken2_NC_012577.1 IMICODJL_21193 Prodigal:2.6 50567 50710 - VFG016306(gb|WP_000239644) 100.0 4.01e-28 (capE) CapE, involved in Poly-gamma-glutamate synthesis VF0141 Capsule VFC0258 Immune modulation Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 A polymer of gamma-D-glutamic acid Inhibits phagocytosis, and it is a monotonous linear polymer that is only very weakly immunogenic that enables the bacteria to evade the host-immune defenses and facilitate systemic invasion and dissemination within the bloodstream; produces a concentration dependent enhancement of the cytotoxicity of LT through an enhancement in the binding and accumulation of protective antigen to its receptors. MVKKVFGWIMPILIVGLLLVTMGTFKRSETLTTDEQKKISDYLQANP Kraken2_NC_012577.1 IMICODJL_21194 Prodigal:2.6 50725 52311 - VFG016302(gb|WP_003159952) 100.0 0.0 (dep/capD) gamma-glutamyltranspeptidase, required for polyglutamate anchoring to peptidoglycan VF0141 Capsule VFC0258 Immune modulation Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 A polymer of gamma-D-glutamic acid Inhibits phagocytosis, and it is a monotonous linear polymer that is only very weakly immunogenic that enables the bacteria to evade the host-immune defenses and facilitate systemic invasion and dissemination within the bloodstream; produces a concentration dependent enhancement of the cytotoxicity of LT through an enhancement in the binding and accumulation of protective antigen to its receptors. MNSFKWGKKIILFCLIVSLMGGIGVSCSFNKIKDSVKQKIDSMGDKGTYGVSASHPLAVEEGMKVLKNGGSAVDAAIVVSYVLGVVELHASGIGGGGGMLIISKDKETFIDYRETTPYFTGNQKPHIGVPGFVAGMEYIHDNYGSLPMGELLQPAINYAEKGFKVDDSLTMRLDLAKPRIYSDKLSIFYPNGEPIETGETLIQTDLARTLKKIQKEGAKGFYEGGVARAISKTAKISLEDIKGYKVEVRKPVKGNYMGYDVYTAPPPFSGVTLLQMLKLAEKKEVYKDVDHTATYMSKMEEISRIAYQDRKKNLGDPNYVNMDPNKMVSDKYISTMKNENGDALSEAEHESTTHFVIIDRDGTVVSSTNTLSNFFGTGKYTAGFFLNNQLQNFGSEGFNSYEPGKRSRTFMAPTVLKKDGETIGIGSPGGNRIPQILTPILDKYTHGKGSLQDIINEYRFTFEKNTAYTEIQLSSEVKNELSRKGLNVKKKVSPAFFGGVQALIKDERDNVITGAGDGRRNGTWKSNK Kraken2_NC_012577.1 IMICODJL_21195 Prodigal:2.6 52308 53543 - VFG000680(gb|AAF13661) 100.0 5.94e-289 (capA) CapA, required for Poly-gamma-glutamate transport VF0141 Capsule VFC0258 Immune modulation Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 A polymer of gamma-D-glutamic acid Inhibits phagocytosis, and it is a monotonous linear polymer that is only very weakly immunogenic that enables the bacteria to evade the host-immune defenses and facilitate systemic invasion and dissemination within the bloodstream; produces a concentration dependent enhancement of the cytotoxicity of LT through an enhancement in the binding and accumulation of protective antigen to its receptors. MRRKLTFQEKLLIFIKKTKKKNPRYVAIVLPLIAVILIAATWVQRTEAVAPVKHRENEKLTMTMVGDIMMGRHVKEIVNRYGTDYVFRHVSPYLKNSDYVSGNFEHPVLLEDKKNYQKADKNIHLSAKEETVKAVKEAGFTVLNLANNHMTDYGAKGTKDTIKAFKEADLDYVGAGENFKDVKNIVYQNVNGVRVATLGFTDAFVAGAIATKEQPGSLSMNPDVLLKQISKAKDPKKGNADLVVVNTHWGEEYDNKPSPRQEALAKAMVDAGADIIVGHHPHVLQSFDVYKQGIIFYSLGNFVFDQGWTRTKDSALVQYHLRDNGTAILDVVPLNIQEGSPKPVTSALDKNRVYRQLTKDTSKGALWSKKDDKLEIKLNHKHVIEKMKKREKQEHQDKQEKENQVSVETTT Kraken2_NC_012577.1 IMICODJL_21196 Prodigal:2.6 53555 54004 - VFG000681(gb|AAF13662) 100.0 3.04e-99 (capC) CapC, involved in Poly-gamma-glutamate synthesis VF0141 Capsule VFC0258 Immune modulation Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 A polymer of gamma-D-glutamic acid Inhibits phagocytosis, and it is a monotonous linear polymer that is only very weakly immunogenic that enables the bacteria to evade the host-immune defenses and facilitate systemic invasion and dissemination within the bloodstream; produces a concentration dependent enhancement of the cytotoxicity of LT through an enhancement in the binding and accumulation of protective antigen to its receptors. MFGSDLYIALVLGVTLSLIFTERTGILPAGLVVPGYLALVFNQPVFMLVVLFISILTYVIVTYGVSRFMILYGRRKFAATLITGICLKLLFDYCYPVMPFEIFEFRGIGVIVPGLIANTIQRQGLPLTIGTTILLSGATFAIMNIYYLF Kraken2_NC_012577.1 IMICODJL_21197 Prodigal:2.6 54019 55413 - VFG000682(gb|AAF13663) 100.0 0.0 (capB) CapB, involved in Poly-gamma-glutamate synthesis VF0141 Capsule VFC0258 Immune modulation Capsule synthesis is encoded by the plasmid pXO2; capBCA encodes membrane associated enzymes, dep, adjacent to the cap region for the encapsulation, degrades the high-molecular weight capsule (H-capsule, >100 KDa) to the lower-molecular weight capsule (L-capsule, <14 KDa); acpA located on plasmid pXO2 is a positive regulator for cap region and is activated by high concentrations of CO2 A polymer of gamma-D-glutamic acid Inhibits phagocytosis, and it is a monotonous linear polymer that is only very weakly immunogenic that enables the bacteria to evade the host-immune defenses and facilitate systemic invasion and dissemination within the bloodstream; produces a concentration dependent enhancement of the cytotoxicity of LT through an enhancement in the binding and accumulation of protective antigen to its receptors. MKNIKIVRILKHDEAIRIEHRISELYSDEFGVVYAGNHLIFNWYQRLYLSRNILISKKSKSRKGLIQMIFIIGICTVFLIIYGIWEQRCHQKRLNSIPIRVNINGIRGKSTVTRLITGVVQEAKYKTVGKTTGTSARMIYWFTDEEQPIKRRKEGPNIGEQRRVVKEAADLEAEALICECMAVQPDYQIIFQNKMIQANVGVIVNVLEDHMDVMGPTLDEVAEAFTATIPYNGHLVTIESEYLDYFKEVAEERNTKVIVADNSRISEEFLRKFDYMVFPDNASLALAVAEALGIDEETAFRGMLNAHPDPGAMRITRFADQSKPAFFVNGFAANDPSSTLRIWERVDDFGYSNLAPIVIMNCRPDRVDRTEQFARDVLPYIKAEIVIAIGETTAPITSAFEKGDIPTQEYWNLEGWSTSEIMSRMRPYLKNRIVYGVGNIHGAAEPLIDMIMEEQIGKKQAKVI Kraken2_NC_012577.1 IMICODJL_21199 Prodigal:2.6 56872 57171 + VFG049937(gb|WP_000152670) 100.0 1.34e-67 (pagR-XO2) metalloregulator ArsR/SmtB family transcription factor VF0665 PagR-XO2 VFC0301 Regulation MTIITNHEIEYKDFEENGELLKIMGHPMRLKIINELYKHKMLNGIQITKILNLPQSTVSQHLCKMKGKILKGNRKGLEIYSSINNPKVEKIIALLIPIE Kraken2_NC_012577.1 IMICODJL_21210 Prodigal:2.6 66848 68299 + VFG049938(gb|WP_000409768) 100.0 0.0 (acpA) capsule synthesis transcriptional regulator AcpA VF0666 AcpAB VFC0301 Regulation MEKDISRKIDLLNILIEEKRWFTLFELEKNLNCSSKTIRKDISIINDLLPKTIFIHSKKGKGVKLSLPQNQSISEAISNLLKKSLTFLAIQQLLEERSNTVTSLADKLYLPISSTNIVLKRVSKYIKKFGLSLEKKPLRIVGDEFQIILMFSERYLESYPDTEWPFTEYKEEMLIDYINYIEEKLEIVFYSNDKRRMAFIMTILFKRIKQGHKVKFSEWIIKETMESIYYKKIFEGKNVIKVNKNRSLNIEEQVLLVIMVKLSRYVSKDENNLKQEELVLYKEGESTTYTYVKNFISILEQELKIDLNNNEEFVYGMIEYCREAFHILKFIPILKAPEKDTCKYIKKHYEETFYLVKRAYNKWGAEMKLTDIPDEEIAKVTMRIVAIGKQHNINRKKVLLITGEGKSWEEYMKSRINKRYGDQLKFVGGHAKILNGNTDNIDNIDIDFIITTVPLNFSWKSIVYVSPILQERDFYEIGIFASK Kraken2_NC_012579.1 IMICODJL_21346 Prodigal:2.6 107143 109101 + VFG049919(gb|AAD32394) 100.0 5.1e-244 (bslA) s-layer protein VF0411 BslA B. anthracis S-layer protein A VFC0001 Adherence "Consists of a canonical Ig-like domain, to which is appended a three-stranded ""cap"" that is highly hydrophobic in character, rich in leucine residues as well as isoleucine, valine, and alanine. This cap comprises a surface-exposed hydrophobic patch." Encodes a major S-layer protein that is located within the pXO1 pathogenicity island that also codes for toxin genes. BslA mediates adherence and entry to epithelial cells by binding integrin alpha2beta1 and complement component C1q;forms a highly hydrophobic coat around B. subtilis biofilms MKKRKIKAITSFTLIGSILFGGNINSTQAESDLKKIVPDQMVPAFLDVPSNHWANVAINNLLKKEIIVGYGNNKFGLGDSVTREQVAAVIYRIKFPEKEVEAEAQNPYRDVNKSSTMFLDEILTLTKMGIFSGDEKGNFRPKSPISRAEMTQVIKNAFNIPVVGKHNFRDVAKDYWANDAISALQSNQLVSGTGNGLFEPYKSVTREEYAQFIFNVLNFEDLVNKEKQLDELNKRRDVINQKIDEFDKLNSQRKDLERMLEELNQKLSQLKQQSPQLQDLKNKLKESQSRLLELNKKDSNRLELNSEIKKLNDRKAELLSLIMELIKQQSEFDKKIKNEKDDLNKKREDLINRIAESKELAKKKAELNTKLVELFKVQEALNKKSGQYLYYINKLDNELRELADKYKNSDNKISRLKNHIGEYNKQLEKIENELEECNKKIDNTKKQLAEFDKSNKKQQELESELVQLNKKIDELGKRHKHRQELEASQKKALDEAKEINKKLAEKDPERQHINDKLKKLNNDWRLTNNELNRLNSELQKVNTKLLGYSQEHQYYNALNKERTELSKKVDEIYQKQSEIDKNYIELNRQLDELSNPKPNEQVQLLKNQINELNSSINQILNHRKNEINNITQRKDHIIDQLNQFPKLRIPNS Kraken2_NC_012579.1 IMICODJL_21350 Prodigal:2.6 111745 112845 + VFG050170(gb|AAD32397) 99.7 1.38e-262 (hasA) hyaluronan synthase VF0667 Hyaluronic acid (HA) capsule VFC0258 Immune modulation MKVAVVVPSYNESASAIVNTINSVLAQDYPIHEIFFVDDGSKDKSAYEVALKMREELLRTQREIAATTKNICSEILGIPDLIVHRLPKNCGKRHAQLWAFKRTTADAIVTIDSDGDLFPNAVRELLKPFNDEKVMATTGHVNIRNRNDNLLTKLIDMRYDNAFRVERAAQSVTGNVLVCSGPLSCYRREVITENLENYGSQMFLGEEVQFGDDRCLTNYAILKGKTVYQSTARCITDAPTTLKQFLKQQLRWNKSFFRESLISLGIGMKKPNVLVWTIFEISLWILFGLSLLLSIILKASHVGLILAVYYLGYISLAVYARNVFYLLKHPLTFLLAPLYGILHVLALLPIRFYALLTIKSNGWGTR Kraken2_NC_012579.1 IMICODJL_21351 Prodigal:2.6 112887 113774 + VFG050173(gb|WP_000702222) 100.0 6.15e-212 (hasC) UTP--glucose-1-phosphate uridylyltransferase VF0667 Hyaluronic acid (HA) capsule VFC0258 Immune modulation MKIRKAIIPAAGLGTRFLPATKAQPKEMLPIVDKPTIQYIVEEAVSSGIEDIIIVSGRGKHVIEDHFDKSYELEQTLFKKNKIKTLEDIECISNLANIHYIRQKEPKGLGHAIYCARRFIGEEPFAVLLGDDIVSSTYPCLKQLIDVYEEHHCSVVGVQRVLETEVSKYGIVKSANQNVNQSIIPISMLVEKPPLETAPSNLAIMGRYILKPDIFEVLKNLPVGSGGEIQLTDAINVLNKQQKVLAFEFDGKRYDVGDKFGFIKATIDFALQRESLKEDVLSYLRNITRDKLINK Kraken2_NC_012579.1 IMICODJL_21352 Prodigal:2.6 113801 115132 + VFG050177(gb|WP_001027044) 100.0 5.93e-319 (hasB) UDP-glucose dehydrogenase VF0667 Hyaluronic acid (HA) capsule VFC0258 Immune modulation MNISIVGTGYVGLVTGVCLSEVGHNVTCIDIDEEKVKKMKLGYSPIFEPCLEELMKNNIIKGRLHFTTNYVDGADGAEIFYIAVGTPQKEDGSADLSFIKQAAINIARTIKNDVIIVVKSTVPVGTNIYIKNLILKNLNYDVKVDIISNPEFLREGSAVNDTFYGDRIVIGSENKTSANVMEEVYKPFGTPIFKTDIQSAEMIKYASNTFLATKISFINGIANLCEMVGADVEKVAQGMGQDKRIGSQFLNAGIGYGGSCFPKDTHALVKVSESLQHKFHLLESVIKLNKNQQTVLIEKIKKRFGSIVGKKIALLGLSFKPNTDDLREAPSIPIARKLVEEGAQVIAYDPVAIKNAREVLPKEVHYVYSTMEALTEADIALVLTEWDEVVDSLLLKASQLMKEPVIFDGRNCFELNEAKNYDVEYHSIGRPSVLREVKGEITA Kraken2_NC_012579.1 IMICODJL_21365 Prodigal:2.6 122931 125333 + VFG000678(gb|AAD32426) 100.0 0.0 (cya) calmodulin sensitive adenylate cyclase, edema factor VF0142 Anthrax toxin VFC0235 Exotoxin AtxA, a pXO1 gene required for transcription of the three toxin genes, also positively regulated encapsulation; the expression of atxA gene is not controlled by CO2 Belongs to the family of bacterial AB toxins:; Composed of a single B subunit called protective antigen (PA) and two alternative A subunits: edema factor (EF) and lethal factor (LF); Monomeric PA displays four structural domains:; Domain 1 contains the proteolytic activation site. Domain 2 is a beta-barrel core containing a large flexible loop for pore formation. Domain 3 is involved in heptamer formation. Domain 4 binds to anthrax toxin receptor (ATR); LF is organized into four domains:; Domain 1 (LFn) is the PA-binding domain. Domain 2 (VIP2-like, VIP2, an ADP-ribosylating toxin from Bacillus cereus) participates in forming a binding pocket for substrate peptide. Domain 3 is a helical bundle that may contribute to substrate specificity by restricting access to the binding pocket. Domain 4 is the catalytic center; PDB code for PA: 1ACC, LF: 1J7N, EF: 1K8T, 1K93, 1K90 The combination of PA and EF is edema toxin (EdTx), the combination of PA and LF is lethal toxin (LeTx); EF is a calcium- and calmodulin-dependent adenylate cyclase that causes dramatic increases in intracellular concentrations of cAMP; LF is a zinc-dependent protease that cleaves mitogen-activated protein kinase kinases (MAPKKs) in their amino-terminal regions. It is a multi-functional virulence factor that appears to play a role in all stages of infection. Early in the infection, it acts to suppress immune cell and cytokine responses, thereby promoting bacterial outgrowth. Later in the disease, it induces the cytokine-independent shock-like death associated with anthrax. PA, EF and LF are secreted independently and assemble at the mammalian cell surface into toxin complexes. PA binds to cell-surface anthrax toxin receptor (ATR), encoded by the tumor endothelial marker 8 (TEM8) gene. ATR is a type I membrane protein with an extracellular von Willebrand factor type A domain (VWA) and is cleaved by furin or a furin-like protease, releases an amino-terminal 20kDa fragment (PA20) and the receptor-bound carboxy-terminal 63kDa fragment (PA63). Recently, a second PA receptor encoded by capillary morphogenesis gene 2 (CMG2) has been identified. It has 60% amino acid identity to ATR/TEM8 within the VWA/I domain, as well as a conserved MIDAS (metal ion dependent adhesion site) motif; PA63 oligomerizes into ring-shaped hepameric or actameric pre-channels and binds 3 or 4 LF/EF substrates respectively. The assembled toxic complexes are then internalized by membrane lipid rafts and directed to endosomes. The PA oligomer transforms into a transmembrane, beta-barrel channel. The proton motive force unfolds and translocates LF and EF through the channel. Once the enzymatic moieties have accessed the cytosolic compartment, they exert their toxic activities. MTRNKFIPNKFSIISFSVLLFAISSSQAIEVNAMNEHYTESDIKRNHKTEKNKTEKEKFKDSINNLVKTEFTNETLDKIQQTQDLLKKIPKDVLEIYSELGGEIYFTDIDLVEHKELQDLSEEEKNSMNSRGEKVPFASRFVFEKKRETPKLIINIKDYAINSEQSKEVYYEIGKGISLDIISKDKSLDPEFLNLIKSLSDDSDSSDLLFSQKFKEKLELNNKSIDINFIKENLTEFQHAFSLAFSYYFAPDHRTVLELYAPDMFEYMNKLEKGGFEKISESLKKEGVEKDRIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKSGVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSITEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQVYEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTADYDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERKPDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKAYIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKKESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQIAPEYKNYFQYLKERITNQVQLLLTHQKSNIEFKLLYKQLNFTENETDNFEVFQKIIDEK Kraken2_NC_012579.1 IMICODJL_21370 Prodigal:2.6 128088 129515 - VFG002040(gb|AAD32423) 100.0 0.0 (AAD32423) pXO1-119 VF0332 AtxA Anthrax toxin activator VFC0301 Regulation A master regulator: it enhances not only the transcription of all three toxin genes, but also that of the cap operon MLTPISIEKEHIRLINLLHFINEQNRWFTIKELSDYLQVADKTVRKYLKLLEDEIPPSWNLLVQKGKGIYLKKPLNESLSFVESKILRKSLNLQICEELVFKKNSMQSLAQKLHLQVGALYPIINQINYDIQSSHLNIKKKPLEISGREQDVRVFMLRLYCNIPNDYWPFPYINKQNITDLINKMEKILNVQMYTYSKHKLCVLFAITISRLLSGNTIDNVSGLILVNKNDDHYKTVASITSELQNSFGVTLHETEISFLALALLLSLGNSITTDSNKTLTSYKKTIMPLAKEITKGIEHKLQLGINYDESFLTYVVLIIKKALDKNFIQYYNYNIKFIRHIKQRHPNTFNTIQECISNLNYTVYSHFDCYEISLLTMHFETQRMLFKNNPKKIYVYTSQGCIHREYISALLEKRYNGLIKIVRNTIINLTNESLQDMEIDIIISNVNLPIKNIPIVQISEFPTERDFHEIKKII Kraken2_NC_012579.1 IMICODJL_21381 Prodigal:2.6 144096 146390 + VFG000677(gb|AAD32414) 99.7 0.0 (pagA) anthrax toxin moiety, protective antigen VF0142 Anthrax toxin VFC0235 Exotoxin AtxA, a pXO1 gene required for transcription of the three toxin genes, also positively regulated encapsulation; the expression of atxA gene is not controlled by CO2 Belongs to the family of bacterial AB toxins:; Composed of a single B subunit called protective antigen (PA) and two alternative A subunits: edema factor (EF) and lethal factor (LF); Monomeric PA displays four structural domains:; Domain 1 contains the proteolytic activation site. Domain 2 is a beta-barrel core containing a large flexible loop for pore formation. Domain 3 is involved in heptamer formation. Domain 4 binds to anthrax toxin receptor (ATR); LF is organized into four domains:; Domain 1 (LFn) is the PA-binding domain. Domain 2 (VIP2-like, VIP2, an ADP-ribosylating toxin from Bacillus cereus) participates in forming a binding pocket for substrate peptide. Domain 3 is a helical bundle that may contribute to substrate specificity by restricting access to the binding pocket. Domain 4 is the catalytic center; PDB code for PA: 1ACC, LF: 1J7N, EF: 1K8T, 1K93, 1K90 The combination of PA and EF is edema toxin (EdTx), the combination of PA and LF is lethal toxin (LeTx); EF is a calcium- and calmodulin-dependent adenylate cyclase that causes dramatic increases in intracellular concentrations of cAMP; LF is a zinc-dependent protease that cleaves mitogen-activated protein kinase kinases (MAPKKs) in their amino-terminal regions. It is a multi-functional virulence factor that appears to play a role in all stages of infection. Early in the infection, it acts to suppress immune cell and cytokine responses, thereby promoting bacterial outgrowth. Later in the disease, it induces the cytokine-independent shock-like death associated with anthrax. PA, EF and LF are secreted independently and assemble at the mammalian cell surface into toxin complexes. PA binds to cell-surface anthrax toxin receptor (ATR), encoded by the tumor endothelial marker 8 (TEM8) gene. ATR is a type I membrane protein with an extracellular von Willebrand factor type A domain (VWA) and is cleaved by furin or a furin-like protease, releases an amino-terminal 20kDa fragment (PA20) and the receptor-bound carboxy-terminal 63kDa fragment (PA63). Recently, a second PA receptor encoded by capillary morphogenesis gene 2 (CMG2) has been identified. It has 60% amino acid identity to ATR/TEM8 within the VWA/I domain, as well as a conserved MIDAS (metal ion dependent adhesion site) motif; PA63 oligomerizes into ring-shaped hepameric or actameric pre-channels and binds 3 or 4 LF/EF substrates respectively. The assembled toxic complexes are then internalized by membrane lipid rafts and directed to endosomes. The PA oligomer transforms into a transmembrane, beta-barrel channel. The proton motive force unfolds and translocates LF and EF through the channel. Once the enzymatic moieties have accessed the cytosolic compartment, they exert their toxic activities. MKKRKVLIPLMALSTILVSSTGNLEVIQAEVKQENRLLNESESSSQGLLGYYFSDLNFQAPMVVTSSTTGDLSIPSSELENIPSENQYFQSAIWSGFIKVKKSDEYTFATSADNHVTMWVDDQEVINKASNSNKIRLEKGRLYQIKIQYQRENPTEKGLDFKLYWTDSQNKKEVISSDNLQLPELKQKSSNSRKKRSTSAGPTVPDRDNDGIPDSLEVEGYTVDVKNKRTFLSPWISNIHEKKGLTKYKSSPEKWSTASDPYSDFEKVTGRIDKNVSPEARHPLVAAYPIVHVDMENIILSKNEDQSTQNTDSQTRTISKNTSTSRTHTSEVHGNAEVHASFFDIGGSVSAGFSNSNSSTVAIDHSLSLAGERTWAETMGLNTADTARLNANIRYVNTGTAPIYNVLPTTSLVLGKNQTLATIKAKENQLSQILAPNNYYPSKNLAPIALNAQDDFSSTPITMNYNQFLELEKTKQLRLDTDQVYGNIATYNFENGRVRVDTGSNWSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIAFGFNESNGNLQYQGKDITEFDFNFDQQTSQNIKNQLAELNVTNIYTVLDKIKLNAKMNILIRDKRFHYDRNNIAVGADESVVKEAHREVINSSTEGLLLNIDKDIRKILSGYIVEIEDTEGLKEVINDRYDMLNISSLRQDGKTFIDFKKYNDKLPLYISNPNYKVNVYAVTKENTIINPSENGDTSTNGIKKILIFSKKGYEIG Kraken2_NC_012579.1 IMICODJL_21382 Prodigal:2.6 147313 147612 + VFG049935(gb|WP_000215715) 100.0 9.409999999999999e-68 (pagR-XO1) transcriptional repressor PagR VF0664 PagR-XO1 VFC0301 Regulation MTVFVDHKIEYMSLEDDAELLKTMAHPMRLKIVNELYKHKALNVTQIIQILKLPQSTVSQHLCKMRGKVLKRNRQGLEIYYSINNPKVEGIIKLLNPIQ Kraken2_NC_012579.1 IMICODJL_21385 Prodigal:2.6 149683 152112 - VFG016210(gb|WP_001022097) 100.0 0.0 (lef) anthrax toxin lethal factor precursor VF0142 Anthrax toxin VFC0235 Exotoxin AtxA, a pXO1 gene required for transcription of the three toxin genes, also positively regulated encapsulation; the expression of atxA gene is not controlled by CO2 Belongs to the family of bacterial AB toxins:; Composed of a single B subunit called protective antigen (PA) and two alternative A subunits: edema factor (EF) and lethal factor (LF); Monomeric PA displays four structural domains:; Domain 1 contains the proteolytic activation site. Domain 2 is a beta-barrel core containing a large flexible loop for pore formation. Domain 3 is involved in heptamer formation. Domain 4 binds to anthrax toxin receptor (ATR); LF is organized into four domains:; Domain 1 (LFn) is the PA-binding domain. Domain 2 (VIP2-like, VIP2, an ADP-ribosylating toxin from Bacillus cereus) participates in forming a binding pocket for substrate peptide. Domain 3 is a helical bundle that may contribute to substrate specificity by restricting access to the binding pocket. Domain 4 is the catalytic center; PDB code for PA: 1ACC, LF: 1J7N, EF: 1K8T, 1K93, 1K90 The combination of PA and EF is edema toxin (EdTx), the combination of PA and LF is lethal toxin (LeTx); EF is a calcium- and calmodulin-dependent adenylate cyclase that causes dramatic increases in intracellular concentrations of cAMP; LF is a zinc-dependent protease that cleaves mitogen-activated protein kinase kinases (MAPKKs) in their amino-terminal regions. It is a multi-functional virulence factor that appears to play a role in all stages of infection. Early in the infection, it acts to suppress immune cell and cytokine responses, thereby promoting bacterial outgrowth. Later in the disease, it induces the cytokine-independent shock-like death associated with anthrax. PA, EF and LF are secreted independently and assemble at the mammalian cell surface into toxin complexes. PA binds to cell-surface anthrax toxin receptor (ATR), encoded by the tumor endothelial marker 8 (TEM8) gene. ATR is a type I membrane protein with an extracellular von Willebrand factor type A domain (VWA) and is cleaved by furin or a furin-like protease, releases an amino-terminal 20kDa fragment (PA20) and the receptor-bound carboxy-terminal 63kDa fragment (PA63). Recently, a second PA receptor encoded by capillary morphogenesis gene 2 (CMG2) has been identified. It has 60% amino acid identity to ATR/TEM8 within the VWA/I domain, as well as a conserved MIDAS (metal ion dependent adhesion site) motif; PA63 oligomerizes into ring-shaped hepameric or actameric pre-channels and binds 3 or 4 LF/EF substrates respectively. The assembled toxic complexes are then internalized by membrane lipid rafts and directed to endosomes. The PA oligomer transforms into a transmembrane, beta-barrel channel. The proton motive force unfolds and translocates LF and EF through the channel. Once the enzymatic moieties have accessed the cytosolic compartment, they exert their toxic activities. MNIKKEFIKVISMSCLVTAITLSGPVFIPLVQGAGGHGDVGMHVKEKEKNKDENKRKDEERNKTQEEHLKEIMKHIVKIEVKGEEAVKKEAAEKLLEKVPSDVLEMYKAIGGKIYIVDGDITKHISLEALSEDKKKIKDIYGKDALLHEHYVYAKEGYEPVLVIQSSEDYVENTEKALNVYYEIGKILSRDILSKINQPYQKFLDVLNTIKNASDSDGQDLLFTNQLKEHPTDFSVEFLEQNSNEVQEVFAKAFAYYIEPQHRDVLQLYAPEAFNYMDKFNEQEINLSLEELKDQRMLARYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQEEKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDSSNPLSEKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKRDIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKINRGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYLENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQLNINQEWNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDLIKKVTNYLVDGNGRFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESRSILLHGPSKGVELRNDSEGFIHEFGHAVDDYAGYLLDKNQSDLVTNSKKFIDIFKEEGSNLTSYGRTNEAEFFAEAFRLMHSTDHAERLKVQKNAPKTFQFINDQIKFIINS Kraken2_NC_012579.1 IMICODJL_21416 Prodigal:2.6 174544 174837 - VFG050076(gb|WP_001971534) 61.3 7.399999999999998e-28 (pagR-XO1) metalloregulator ArsR/SmtB family transcription factor VF0664 PagR-XO1 VFC0301 Regulation MTTIQAGNEMHKIPEADVELLKIMAHPVRLQIVKELEHRKICNVTQLTELLDIPQSTVSQHLSKMRGKILRSERKGLEMYYHIANSKACQIVSVLGL Kraken2_NC_011777.1 IMICODJL_21651 Prodigal:2.6 166231 166812 - VFG000077(gb|NP_465991) 78.2 8.48e-108 (clpP) ATP-dependent Clp protease proteolytic subunit VF0074 ClpP VFC0282 Stress survival 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes Serine protease involved in proteolysis and is required for growth under stress conditions MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLESQDPEKDIHIYINSPGGSITAGMAIYDTMQFIKPQVSTICIGMAASMGAFLLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILFLREKLNQILADRTGQPLEVLQRDTDRDNFMTAEKALEYGLIDKIFTNR Kraken2_NC_011777.1 IMICODJL_21691 Prodigal:2.6 200925 201224 + VFG050075(gb|WP_000215714) 66.7 2.7699999999999997e-42 (pagR-XO1) transcriptional repressor PagR VF0664 PagR-XO1 VFC0301 Regulation MTSFANQHIENTILEEDVELLKVMAHPMRLKLISELSKHKTLNVTQMTEILNIPQSTVSQHLSKMKGKVLRGNRQGLEIYYSIENQKAKEIMGLLGPLQ Kraken2_NZ_CP076055.1 IMICODJL_21868 Prodigal:2.6 46462 47022 - VFG042890(gb|WP_000334696) 62.9 1.2699999999999996e-68 (STY_RS21730) lytic transglycosylase domain-containing protein VF0966 Type IV pili VFC0001 Adherence MSGGKVPLRLISLILLCSLIYPARASYIAPKQIWTNKWDNCFAAAGARYQIEPLLLKAISAGESSLKPGAININKDRKTGKASSTDYGLMQINSTHIPKLIKMGVIKKSEDLITKPCLNIHIGSWILARHFQICGVSWNCLGSYNAGFRKDRHETREQYANKVWRIYRDMKGICLPGQGGRQCRQS Kraken2_NZ_CP076055.1 IMICODJL_21869 Prodigal:2.6 47032 47646 - VFG002315(gb|WP_011817101) 60.1 2.1700000000000002e-70 (pilS) putative type IV pilus prepilin VF0401 Type IV pili VFC0001 Adherence Pil operon maybe acquired by horizontal gene transfer Contributes to the virulence of Y. pseudotuberculosis. MLIQNINANVLKKNEKETSHDKGWGIMEQGAIALVVIIVLALVFGGLYMLRSRTGVANESSNIQTIITSTQGLLKGSDGYTFTSGAKMTGALIQMGGVPKTMTVRGTPSSGTATLYNSWGGAVTVAPASTSGFNNGFTVTYEKVPQDACIQIATQISRTGLTNGITLNSTAHSDGKVTTEEASAQCTADNGSTGTNKLIFTING Kraken2_NZ_CP076057.1 IMICODJL_21990 Prodigal:2.6 24690 25376 - VFG001445(gb|AAA92657) 100.0 6.42e-147 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MCALDRRERPLNSQSVNKYILNVQNIYRNSPVPVCVRNKNRKILYANGAFIELFSREDKPLSGESYIRLQVEIFLSSLELECQALGHGSAFCRRFNFHGEIYQIRMENVSFYNDESVVLWQINPFPDYPFFALNQSGSNTNTSDKLTIWNDLSPGTLVVFSFYMLGVGHATIARELGITDRASEDRIKPVKRKIKEFFEHFDLFRVSCIYKGEIDSLLSIIREFYGVK Kraken2_NZ_CP076054.1 IMICODJL_22180 Prodigal:2.6 70141 72021 - VFG044067(gb|WP_001283335) 99.2 0.0 (ECS88_RS00560) colicin-like pore-forming protein VF1183 Colicin Ia VFC0235 Exotoxin MSDPVRITNPGAESLGYDSDGHEIMAVDIYVNPPRVDVFHGTPPAWSSFGNKTIWGGNEWVDDSPTRSDIEKRDKEIAAYKNTLSAQQKENENKRTEAGKRLSAAIAAREKDENTLKTLRAGNADAADITRQEFRLLQAELREYGFRTEIAGYDALRLHTESRMLFADADSLRISPREARSLIEQAEKRQKDAQNADKKAADMLAEYERRKGILDTRLSELEKNGGAALAVLDAQQARLLGQQTRNDRAISEARNKLSSVTESLNTARNALTRAEQQLTQQKNTPDGKTIVSPEKFPGRSSTNHSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLTHSGLDYKRNILNDRNPVVTEDVEGDKKIYNAEVAEWDKLRQRLLDARNKITSAESAVNSARNNLSARTNEQKHANDALNALLKEKENIRNQLAGINQKIAEEKRKQDELKATKDAINFTTEFLKSVSEKYGAKAEQLAREMAGQAKGKKIRNVEEALKTYEKYRADINKKINAKDRAAIAAALESVKLSDISSNLNRFSRGLGYAGKFTSLADWITEFGKAVRTENWRPLFVKTEAIIAGNAATALVALVFSILTGSALGIIGYGLLMAVTGALIDESLVEKANKFWGI Kraken2_NZ_CP076054.1 IMICODJL_22203 Prodigal:2.6 92618 93178 + VFG042890(gb|WP_000334696) 64.3 3.1199999999999996e-69 (STY_RS21730) lytic transglycosylase domain-containing protein VF0966 Type IV pili VFC0001 Adherence MSGGTVPLRLISLILLFSLIPPARASYVAPKQIWTNKWDNCFAAAGARYQIEPLLLKAISAGESSLRPGAININKDKKTGKASSTDYGLMQINSTHIPKLINMGVIKKSEDLITKPCLNIHIGSWILARHFQICGVSWNCLGSYNAGFRKDRHETREQYANKIWRIYRDMKGICLPGQGGRQCRQS Kraken2_NZ_CP076056.1 IMICODJL_22264 Prodigal:2.6 47788 48348 + VFG042890(gb|WP_000334696) 62.9 1.2699999999999996e-68 (STY_RS21730) lytic transglycosylase domain-containing protein VF0966 Type IV pili VFC0001 Adherence MSGGKVPLRLISLILLCSLIYPARASYIAPKQIWTNKWDNCFAAAGARYQIEPLLLKAISAGESSLKPGAININKDRKTGKASSTDYGLMQINSTHIPKLIKMGVIKKSEDLITKPCLNIHIGSWILARHFQICGVSWNCLGSYNAGFRKDRHETREQYANKVWRIYRDMKGICLPGQGGRQCRQS Kraken2_NZ_CP076059.1 IMICODJL_22494 Prodigal:2.6 77866 79041 + VFG036084(gb|WP_001020413) 100.0 1.33e-284 (senB) enterotoxin production-related protein TieB VF1136 Enterotoxin SenB/TieB VFC0235 Exotoxin MNIFTLSKAPLYLLISLFLPTMAMAIDPPERELSRFALKTNYLQSPDEGVYELAFDNASKKVFAAVTDRVNREANKGYLYSFNSDSLKVENKYTMPYRAFSLAINQDKHQLYIGHTQSASLRISMFDTPTGKLVRTSDRLSFKAANAADSRFEHFRHMVYSQDSDTLFVSYSNMLKTAEGMKPLHKLLMLDGTTLALKGEVKDAYKGTAYGLTMDEKTQKIYVGGRDYINEIDAKNQTLLRTIPLKDPRPQITSVQNLAVDSASDRAFVVVFDHDDRSGTKDGLYIFDLRDGKQLGYVHTGAGANAVKYNPKYNELYVTNFTSGTISVVDATKYSITREFNMPVYPNQMVLSDDMDTLYIGIKEGFNRDWDPDVFVEGAKERILSIDLKKS Kraken2_NZ_CP076059.1 IMICODJL_22531 Prodigal:2.6 109072 109986 + VFG012575(gb|WP_000949004) 99.7 3.59e-220 (sitA) iron/manganese ABC transporter substrate-binding protein SitA VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MLSIKKVTMLLGCLVLTCSIAFQASAAEKFKVITTFTIIADMAKNVAGDAAEVSSITKPGAEIHEYQPTPGDIKRAQGAQLILANGMNLELWFQRFYQHLNGVPEVIVSSGVTPVGITEGPYEGKPNPHAWMSPDNALIYVDNIRDAFIKYDPINAQTYQRNADTYKAKITQTLAPLRKQIAELPENQRWMVTSEGAFSYLARDLGLKELYLWPINADQQGTPQQVRKVVDIVKKNHIPAVFSESTISDKPARQVARETGAHYGGVLYVDSLSTENGPVPTYIDLLKVTTSTLVQGIKAGKREK Kraken2_NZ_CP076059.1 IMICODJL_22532 Prodigal:2.6 109989 110813 + VFG034214(gb|WP_000983710) 100.0 3.3500000000000003e-192 (sitB) iron/manganese ABC transporter ATP-binding protein SitB VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MQSAGIVVNDVTVTWRNGHTALRDASFTVPGGSIAALVGVNGSGKSTLFKAIMGFVRLTSGKISVLGIPTRQALQKNLVAYVPQSEEVDWSFPVLVEDVVMMGRYGHMGMLRIAKKRDRQIVTDALERVDMVDFRHRQIGELSGGQKKRVFLARAIAQQGDVILLDEPFTGVDVKTEAKIISLLRELRAEGKTMLVSTHNLGSVTTFCDYTVMVKGTVLASGPTDTTFTAENLELAFSGVLRHVTLNGSEESIITDDERPFVAHRPSAVQREER Kraken2_NZ_CP076059.1 IMICODJL_22533 Prodigal:2.6 110810 111667 + VFG012585(gb|WP_001101723) 100.0 1.48e-198 (sitC) iron/manganese ABC transporter permease subunit SitC VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MNVLLEPFSYEYMLNAMWVSAMVGGLCAFLSCYLMLKGWSLIGDALSHSIVPGVAGAYMLGLPFSLGAFFSGGLAAGSMLFLNQLTRLKEDAIIGLIFSSFFGLGLFMVSLNPTSVNIQTIVLGNILAIDPADILQLTIIGILSIIVLFFKWKDLMVTFFDENHARAIGLHPGRLKILFFTLLSVSTVAALQTVGAFLVICLVVTPGATAWLLTDRFPRLLMIAVTIGSVTSFLGAWVSYFLDGATGGIIVVAQTLLFLLAFVFAPTHGLLANRRRAHKALEDRS Kraken2_NZ_CP076059.1 IMICODJL_22534 Prodigal:2.6 111664 112521 + VFG012590(gb|WP_000968139) 100.0 1.78e-190 (sitD) iron/manganese ABC transporter permease subunit SitD VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MMALLLEPLQFTFMSHALLISLVVSIPCALLSVFLVLKSWALMGDAMSHAVFPGIVLAWILGLPLATGAFVAGVFCAVATGYLKDNSRIKQDTVMGIVFSGMFAAGLILYIAVKPDVHLDHILFGDMLGITIGDIIQTVIIAGLVTLVISVKWRDFLLFSFDYQQAQASGLHTRWLHYGLLCMVSLTIVATLKAVGIILSISLLIAPGAIAVLLTQRFHIALLLATGISILVSMTGVWLSFFIDSAPAPTIVVLFAVMFIMTFTVTSINARTKENAEPRDLLSSD Kraken2_NZ_CP076059.1 IMICODJL_22580 Prodigal:2.6 145238 145924 + VFG001445(gb|AAA92657) 100.0 6.42e-147 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MCALDRRERPLNSQSVNKYILNVQNIYRNSPVPVCVRNKNRKILYANGAFIELFSREDKPLSGESYIRLQVEIFLSSLELECQALGHGSAFCRRFNFHGEIYQIRMENVSFYNDESVVLWQINPFPDYPFFALNQSGSNTNTSDKLTIWNDLSPGTLVVFSFYMLGVGHATIARELGITDRASEDRIKPVKRKIKEFFEHFDLFRVSCIYKGEIDSLLSIIREFYGVK Kraken2_NZ_CP065714.1 IMICODJL_22982 Prodigal:2.6 57423 59297 - VFG043573(gb|NP_219906) 61.6 1.83e-246 (dnaK) chaperone protein DnaK VF0713 Adherence; porin VFC0001 Adherence MAKAIGIDLGTTNSCVAVMEGKEPKVIENAEGARTTPSMVAFRPDGEVLVGAAAKRQAITNPEQTLFAIKRLIGRRYDDPIVQKDKGMVPYKIVPGANGDAWVEVNGKKSSPSEISAHILRKMKETAEKYLGEPVTEAVITVPAYFNDAQRQATKDAGTIAGLEVLRIINEPTAAALAYGLEKKKAGTIAVYDLGGGTFDVSILELGDGVFEVKSTNGDTFLGGEDFDKRIIDFLADEFRKEQGIDLRQDRLALQRLKEAAEKAKIELSSASQTSVNLPFITADQSGPKHLDISLTRAKLEALVDDLISRTMGPCKAALEDAGLNADQLDEVVLVGGMTRMPKVVEAVKTIFGREPHQGVNPDEVVALGAAIQAGVLKGQVEDVLLLDVTPLSLGIETLGGVMTKLIDRNTTIPTKKSQTFSTAEDNQPAVTIRVFQGEREMAEDNKLLGQFNLENIAPAPRGVPQIEVTFDIDANGIVNVSATDKGTGREQKITIQSSGGLSEEDIKRAVRDAEEHASEDRKRRELAEAKNQSDALIFLSEKTLADAGDRVAAADRQAVEDAVSNLKTAMQGDQIEDIRARGEDLQSATQKVASAQRAEPGSTSSADDGIVDAEFEEADDAKK Kraken2_NZ_CP065714.1 IMICODJL_23026 Prodigal:2.6 92485 94104 + VFG010484(gb|WP_197535716) 65.1 1.61e-234 (htpB) Hsp60, 60K heat shock protein HtpB VF0159 Hsp60 VFC0001 Adherence Mediate a complement-independent attachment to mammalian and amoebal host cells Specific receptors have not been identified MAAKEVRFSTDARDRMLRGVDTLADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELKDKFENMGAQLIREVASKTNDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDLAVGAVVDDLKAHARRISANSEIAQVATISANGDTEVGQILAEAMEKVGNEGVITVEEAKSLATELEVVEGMQFDRGYLSPYFITNPEKLRVELEDPYILIHEKKLSNLQALVPLLEKVIQSGRPLLIIAEDVEGDALATLVVNKLRGGLQVAAVKAPGFGDRRKAMLEDIAVLTGGNVVSEDLGIKLENVTVNMLGRAKKVVIDKDDTTIIDGAGQKSDIDGRAAQIRQQIETTTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALHATRAAVEEGILPGGGIPLLRAVKALESLSAANDDQKAGIEIVRRALKAPARQIVDNAGEDGAYVVGKLGEGSDYNWGFNAATGEYEDLVRAGVIDPAKVVRTALQDAASVSGLLITTEALIAELPKDEKPAPVPAMDY Kraken2_NZ_CP065714.1 IMICODJL_23329 Prodigal:2.6 379969 380238 - VFG038671(gb|WP_011705282) 60.5 3.24e-07 (fliQ) flagellar biosynthetic protein FliQ VF0473 Polar flagella VFC0204 Motility Types of bacterial movement: swimming, swarming, gliding, twitching and sliding. Only swimming and swarming are correlated with the presence of flagella. Swimming is an individual endeavour, while swarming is the movement of a group of bacteria; constitutively expressed for motility in liquid environments Necessary for motility, adhesion and invasion; glycosylation of the flagellin may play a role in provoking a proinflammatory response MDQSILLDETGRMLAVAGLICVVLLVPMMIVGLIISIIQAATSISEQTLSFVPKLIALGVCLVIFGSAATELLTKFTAELFAVIASMGR Kraken2_NZ_AP026722.1 IMICODJL_23570 Prodigal:2.6 69104 73030 - VFG002164(gb|WP_002395058) 95.4 0.0 (prgB/asc10) aggregation substance PrgB/Asc10 VF0352 AS Aggregation substance VFC0001 Adherence AS is the common designation for a group of proteins that are encoded on pheromone-inducible conjugative plasmids and that are highly similar at the amino acid level.; pheromone responsive bacterial adhesin that mediates efficient contact between donor and recipient bacterium, facilitating plasmid conjugation; AS is expressed by the donor cell, the bacterial conjugation process requires the 'binding substances' (BS) be expressed on the surface of the recipient cell Proteinaceous, hair-like structure on the cell surface Contributes to pathogenicity by enhancing cell adhesion to cultured renal tubular cells and intestinal epithelial cells and may involve in internalization into enterocytes; promoting direct, opsonin-independent binding of E. faecalis to human neutrophils via a complement receptor-mediated mechanism, and thus protecting E. faecalis from killing the polymorphonuclear leukocytes, an important urinary tract defense element. But AS has not been directly assessed as a urovirulence factor. A role in urovirulence has been directly demonstrated only for Esp;Asc10 and Asa1 have been implicated in binding to components of the extracellular matrix such as fibrin, fibronectin, thrombospondin, vitronectin and collagen type I. MKQQTEVKKRFKTYKAKKRWVTAPILFIGVLGVVGLATDNVQAAELDSQPGTTTVQPDNPDLQSGKETPKTAVSEEAALQKDTTSQPTKVEEVAPENKGTEQSSATPNDTINAQQPTAEAEKSAQEQPVVSPETANEPLGQPTEVAPAENEANKSTIIPKEFETPDVDKAVDEAKKDPNITVVEKPAEDLGNVSSKDLAAKEKEVDKLQKEQAKKIAQQAAELKAKNEKIAKENAEIAAKNKAEKERYEKEVAEYNKHKNENSYVNEAISKNLVFDQSVVTKDTKISSIKGGKFIKATDFNKVNAGDSKDIFTKLRKDMGGKATGNFQNSFVKEANLGSNGGYAVLLEKNKPVTVTYTGLNASYLGRKITKAEFVYELQSSPSQSGTLNAVFSNDPIITAFIGTNRVNGKDVKTRLTIKFFDASGKEVLPDKASPFAYALSSLNSSLTNKGGHAEFVSDFGANNAFKYINGSYVKKQADGKFYSPEDIDYGTGPSGLKNSDWDAVGHKNAYFGSGVGLANGRISFSFGMTTKGKSNVPVSSAQWFAFSTNLNAKSVTPKRQFNSPKEPEKATIEFNRYKANVVPVLVPNKEVTDGQKNINDLNLKRGDSLQYIVTGDTTELAKVDPKTVTKQGIRDTFDAEKVTIDLSKVKVYQADASLNEKDLKAVAAAINSGKAKDVTASYDLHLDQNTVTAMMKTNADGSVVLAMGYKYLLVLPFVVKNVEGDFENTAVQLTNDGETVTNTVINHVPRSNPSKDVKADKNGTVGSVSLHDKDIPLQTKIYYEVKSSERPANYGGITEEWGMNDVLDTTHDRFTGKWHAITNYDLKVGDKTLKAGTDISAYILLENKDNKDLTFTMNQALLAALNEGSNKVGKQAWSVYLEVQRIKTGDVENTQTENYNKELVRSNTVVTHTPDDPKPTKAVHNKKGEDINHGKVARGDVLSYEMTWDLKGYDKDFAFDTVDLATGVSFFDDYDETKVSPIKDLLRVKDSKGVDITNQFTISWDDAKGTVTISAKDPQAFILAYGGQELRVTLPTKVKANVSGDVYNSAEQNTFGQRIKTNTVVNHIPKVNPKKDVVIKVGDKQSQNGATIKLGEKFFYEFTSSDIPAEYAGVVEEWSINDKLDVKHDKFSGQWSVFANSAFVLADGTKVNKGDDISKLFTMTFDKGVVKITASQAFLDAMNLKENKHVAHSWKAFIGVERIAAGDVYNTIEESFNNEKIKTNTVVTHTPEKPQTPQTPPEKTVIVPPTPKTPQAPVEPLVVEKASIVPELPKTGEKQNVLLTVAGSLAALLGLAGLGFKRRKETK Kraken2_NZ_AP026715.1 IMICODJL_23760 Prodigal:2.6 67904 71821 + VFG002164(gb|WP_002395058) 96.1 0.0 (prgB/asc10) aggregation substance PrgB/Asc10 VF0352 AS Aggregation substance VFC0001 Adherence AS is the common designation for a group of proteins that are encoded on pheromone-inducible conjugative plasmids and that are highly similar at the amino acid level.; pheromone responsive bacterial adhesin that mediates efficient contact between donor and recipient bacterium, facilitating plasmid conjugation; AS is expressed by the donor cell, the bacterial conjugation process requires the 'binding substances' (BS) be expressed on the surface of the recipient cell Proteinaceous, hair-like structure on the cell surface Contributes to pathogenicity by enhancing cell adhesion to cultured renal tubular cells and intestinal epithelial cells and may involve in internalization into enterocytes; promoting direct, opsonin-independent binding of E. faecalis to human neutrophils via a complement receptor-mediated mechanism, and thus protecting E. faecalis from killing the polymorphonuclear leukocytes, an important urinary tract defense element. But AS has not been directly assessed as a urovirulence factor. A role in urovirulence has been directly demonstrated only for Esp;Asc10 and Asa1 have been implicated in binding to components of the extracellular matrix such as fibrin, fibronectin, thrombospondin, vitronectin and collagen type I. MKQQTEVKKRFKTYKAKKRWVTAPILFIGVLGVVGLATDNVQAAELDSQPGTTTVQPDNPDLQSGKETPKTAVSEEAALQKDTTSQPTKVEEVAPENKGTEQSSATPNDTINAQQPTAEAEKSAQEQPVVSPETANEPLGQPTEVAPAENEANKSTIIPKEFETPDVDKAVDEAKKDPNITVVEKPAEDLGNVSSKDLAAKEKEVDKLQKEQAKKIAQQAAELKAKNEKIAKENAEIAAKNKAEKERYEKEVAEYNKHKNENSYVNEAISKNLVFDQSVVTKDTKISSIKGGKFIKATDFNKVNAGDSKDIFTKLRKDMGGKATGNFQNSFVKEANLGSNGGYAVLLEKNKPVTVTYTGLNASYLGRKITKAEFVYELQSSPSQSGTLNAVFSNDPIITAFIGTNRVNGKDVKTRLTIKFFDASGKEVLPDKASPFAYALSSLNSSLTNKGGHAEFVSDFGANNAFKYINGSYVKKQADGKFYSPEDIDYGTGPSGLKNSDWDAVGHKNAYFGSGVGLANGRISFSFGMTTKGKSNVPVSSAQWFAFSTNLNAKSVTPKRQFNSPKEPEKATIEFNRYKANVVPVLVPNKEVTDGQKNINDLNLKRGDSLQYIVTGDTTELAKVDPKTVTKQGIRDTFDAEKVTIDLSKVKVYQADASLNEKDLKAVAAAINSGKAKDVTASYDLHLDQNTVTAMMKTNADGSVVLAMGYKYLLVLPFVVKNVEGDFENTAVQLTNDGETVTNTVINHVPRSNPSKDVKADKNGTVGSVSLHDKDIPLQTKIYYEVKSSERPANYGGITEEWGMNDVLDTTHDRFTGKWHAITNYDLKVGDKTLKAGTDISAYILLENKDNKDLTFTMNQALLAALNEGSNKVGKQAWSVYLEVQRIKTGDVENTQTENYNKELVRSNTVVTHTPDDPKPTKAVHNKKGEDINHGKVARGDVLSYEMTWDLKGYDKDFAFDTVDLATGVSFFDDYDETKVSPIKDLLRVKDSKGVDITNQFTISWDDAKGTVTISAKDPQAFILAYGGQELRVTLPTKVKANVSGDVYNSAEQNTFGQRIKTNTVVNHIPKVNPKKDVVIKVGDKQSQNGATIKLGEKFFYEFTSSDIPAEYAGVVEEWSINDKLDVKHDKFSGQWSVFANSAFVLADGTKVNKGDDISKLFTMTFDKGVVKITASQAFLDAMNLKENKHVAHSWKAFIGVERIAAGDVYNTIEESFNNEKIKTNTVVTHTPEKPQTPPEKTVIVPPTPKTPQAPVEPLVVEKASIVPELPKTGEKQNVLLTVAGSLAALLGLAGLGFKRRKETK Kraken2_NZ_CP116348.1 IMICODJL_23911 Prodigal:2.6 80183 81568 + VFG034652(gb|WP_000074204) 72.3 1.03e-226 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPAAPVPQQFSLSRNSLMPAVNGYQDTGWRNFFVDPQVTRLITEALNNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSDADRQSYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYQQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADASIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_CP116348.1 IMICODJL_24095 Prodigal:2.6 247672 247869 + VFG010906(gb|WP_011213314) 64.9 1.92e-20 (csrA) carbon storage regulator CsrA VF0261 CsrA VFC0301 Regulation Belongs to a highly conserved family of global regulators that typically control stationary phase traits post-transcriptionally Post-transcriptional repression of the transmission regulon Binds to particular mRNAs at a consensus sequence encompassing the ribosome binding site (RBS), destabilizing the mRNAs and preventing their translation MLILTRRVGEIIRIGDDITVTLLGVKGQQVKFGTSAPKEVNVHREEIYDRIHGERVSAVSRKNLY Kraken2_NZ_CP116424.1 IMICODJL_24684 Prodigal:2.6 64076 65116 + VFG007659(gb|WP_011261022) 61.4 3.4400000000000004e-160 (rmlB) dTDP-glucose 4,6-dehydratase VF0624 Capsular polysaccharide VFC0258 Immune modulation MKILVTGGAGFIGSAVIRLAVARGHEVVNLDALTYAGCLENLVSVADDPLYTFEHADIRDRPALDRIFTEHLPDAVMHLAAESHVDRSIDGPGDFIETNIIGTYNMLEAARSYWVAQGRPEAFRFHHVSTDEVYGSLGAEGIFTEDSPYDPRSPYSASKASSDHLVCAWHETYGLPVVLTNCSNNYGPFHFPEKLVPVVILNALAGKPIPVYGQGLNVRDWLYVEDHADALLLVLEKGASGRRYNIGGENEARNIDLVKTICSILDQKRPKETRYADQITFVQDRAGHDLRYAIDPSRIRDELGWRPSVTLEEGLELTVQWYLNNEGWWRAMQNCDGVGQRLGTKG Kraken2_NZ_CP116424.1 IMICODJL_24686 Prodigal:2.6 65969 66838 + VFG047033(gb|WP_012280623) 62.0 6.190000000000001e-125 (wbtL) glucose-1-phosphate thymidylyltransferase VF0542 LPS VFC0258 Immune modulation The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion A key virulence factor does not signal through, and is not an agonist of, toll like receptor 4 (TLR-4) and has little endotoxic activity Francisella lipid A is a very poor stimulant of the host's innate immunity. The lack of immune recognition of Franciscella lipid A has been attributed to several structural differences compared to E. coli lipid A. These include (1) the absence of phosphate at the 40 position as well as the modification of 1-phosphate with GalN and (2) tetraacylation of lipid A with longer acyl chains (16–18 carbons); An unusual feature of the Francisella LPS core region is the presence of a single Kdo unit. Francisella initially synthesizes its LPS with two Kdo sugars and Kdo hydrolase is involved in removing the second, side-chain Kdo moiety. A probable scenario is the lack of an extra Kdo may alter the bacterial surface and result in decreased access of additional surface molecules to the host’s innate immune system MSKRKGIILAGGSGTRLYPITMGISKQLLPIYDKPMIYYPLSVLMLGGIRDIAIITTPQDQEQFIRTLGDGSQWGINLSYIVQENPDGLAQAYLLAEDFLASAPSAMVLGDNIFFGHGLPDMLAAADARIEGGTVFGYHVSDPKRYGVVSFDADGIAKEIIEKPDVPPSNYAVTGLYFLDGDAPKHAAEVQPSARGELEITSLLCQYLQAGKLQVERMGRGYAWLDTGTHGSLLDAGNFVRTLTERQGLQTGCLEEIAFKYGWISEAALAERAEMFTKNDYGSYLATLK Kraken2_NZ_CP116424.1 IMICODJL_24708 Prodigal:2.6 86655 87686 - VFG047048(gb|WP_014714814) 62.0 6.86e-91 (wbtL) glucose-1-phosphate thymidylyltransferase VF0542 LPS VFC0258 Immune modulation The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion A key virulence factor does not signal through, and is not an agonist of, toll like receptor 4 (TLR-4) and has little endotoxic activity Francisella lipid A is a very poor stimulant of the host's innate immunity. The lack of immune recognition of Franciscella lipid A has been attributed to several structural differences compared to E. coli lipid A. These include (1) the absence of phosphate at the 40 position as well as the modification of 1-phosphate with GalN and (2) tetraacylation of lipid A with longer acyl chains (16–18 carbons); An unusual feature of the Francisella LPS core region is the presence of a single Kdo unit. Francisella initially synthesizes its LPS with two Kdo sugars and Kdo hydrolase is involved in removing the second, side-chain Kdo moiety. A probable scenario is the lack of an extra Kdo may alter the bacterial surface and result in decreased access of additional surface molecules to the host’s innate immune system MKSLKKVTVIGGSGFVGTNLCQKLADRQIPFEIIDIKESRRFPEKCKMGDVRDIMSLRNTVTGDIVVNLAAVHRDDVSDKSEYFRTNVEGAENLAKVCTEKCIRKIVFTSSVAVYGFAEPGTDEAGIREIAVITTPQDQEQFQRTLGDGSQWGISLSYITQPSPDGLAQAFILAEEFLEGAPSALVLGDNIFYGHGLPEMLAKADAKPNGGTVFGYQVSDPERYGVVDFDAEGQAKSIIEKPEVPPSNFAVTGLYFLDGSAPDRARQVAPSARGELEITSLLEMYLQEGALSVERMGRGFAWLDTGTHESLLDAGTFVRTLEKRQGQQAGCLEEIAYLQCRAP Kraken2_NZ_CP116425.1 IMICODJL_24960 Prodigal:2.6 74554 75729 + VFG048964(gb|WP_012967597) 66.9 7.249999999999999e-189 (ugd) UDP-glucose 6-dehydrogenase VF0560 Capsule VFC0258 Immune modulation The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. Assisting in evading the host immune system by protecting bacteria from opsonophagocytosis and serum killing MSKTKIAVVGIGYVGLSNAVLLAQHNNVTAVDLNAERVAQVNARRAPIVDPEIEQYLAEKPLTLGATTDAEAAYRNADYVLIATPTNYDPRTNVFDTSSVEAVVRDVLAVTKTATIVIKSTVPVGYTAGLSAKVNSDQVIFSPEFLREGRALYDNLHPSRVVVGEDSPRARRFAELLAEGAIDDDIPMLFTGASEAEAVKLFANTFLAMRVAYFNELDSYALTNGLDTRQIIDGVCLDPRIGGHYNNPSFGYGGYCLPKDSKQLLANYSDVPQNLINAVVEANRTRKDFVSEQILALGPQRVGIYRLVMKARSDNFRQSSVQGIMKRLKAKGIEVIVYEPVLQEERFFGSEVTRDLEAFKTRVDVIVANRNHPDLADVPDKVFTRDLFGAD Kraken2_NZ_CP116425.1 IMICODJL_24962 Prodigal:2.6 76789 77433 - VFG006496(gb|WP_011115254) 60.4 4.840000000000001e-85 (ureG) urease accessory protein (ureG) VF0050 Urease VFC0282 Stress survival ~550kDa nickel metalloenzyme comprised of two distinct subunits-UreA and UreB, the UreEFGH proteins are required for activation of urease by incorporating nickel ions into the urease apoenzyme, UreI functions as an acid-dependent urea channel; PDB code: 1E9Z An important colonization factor, contributes to acid resistance, epithelial cell damage, chemotactic behavior, and nitrogen metabolism A Ni2+-containing enzyme, catalyzes the hydrolysis of urea to ammonium and carbon dioxide. Urea channels (UreI) present in the inner membrane are opened at pH<6.5, allowing delivery of urea to urease. The ammonia produced diffuses into, and thus buffers the periplasm. MKRNNGPLRVGIGGPVGAGKTTLTAALSRALRDRLSIGVITNDIYTQEDAEALMRMQVLPQDRIIGVETGGCPHTAIREDASINLAAVAEMVSRHPDVEVVLIESGGDNLSATFSPELADVTLYVIDVAAGEEIPRKGGPAITKSDILVINKTDLAPHVGASLNVMQRDSARMRPDLPTVFCALKSGEGIDTLLAHLAQVGGLDLAPMDPVSAA Kraken2_NZ_CP116425.1 IMICODJL_24965 Prodigal:2.6 78587 80311 - VFG006476(gb|WP_011115250) 63.7 1.4e-261 (ureB) urease beta subunit UreB, urea amidohydrolase VF0050 Urease VFC0282 Stress survival ~550kDa nickel metalloenzyme comprised of two distinct subunits-UreA and UreB, the UreEFGH proteins are required for activation of urease by incorporating nickel ions into the urease apoenzyme, UreI functions as an acid-dependent urea channel; PDB code: 1E9Z An important colonization factor, contributes to acid resistance, epithelial cell damage, chemotactic behavior, and nitrogen metabolism A Ni2+-containing enzyme, catalyzes the hydrolysis of urea to ammonium and carbon dioxide. Urea channels (UreI) present in the inner membrane are opened at pH<6.5, allowing delivery of urea to urease. The ammonia produced diffuses into, and thus buffers the periplasm. MPAQIKRGDYAAMFGPTVGDRVRLADTDLIIEVERDLTTGEGRAYGEEVKFGGGKVIRDGMGQSQVTRAGGAVDTVITNALIVDHTGIYKADVGLKDGRIAKIGKAGNPDTQPGVDIIIGPGTEVIAGEGRILTAGGFDSHIHFICPQQIEDALHSGLTTMLGGGTGPAHGTLATTCTPGGWHIGRMMQAADAFPMNLAFAGKGNASQPAALEEQINAGACALKLHEDWGTTPAAIDCCLGVADAMDVQVMIHTDTLNESGFVEHTVKAMKGRTIHAFHTEGAGGGHAPDIIKICGEEHVLPSSTNPTRPFTVNTLEEHLDMLMVCHHLDKSIPEDVAFAESRIRRETIAAEDILHDMGAFSIIASDSQAMGRVGEVLIRTWQTANKMKKQRGRLPEETGDNDNFRVRRYIAKYTINPAIAHGISTHIGSIEEGKRADLVLWNPAFFGVKPEMVLLGGSIVCAQMGDPNASIPTPQPVYSRPMFGAYGRAVENSAVVFVSEAAEAAGVGGSLGLAKQTLAVRNTRKIGKRDLKLNDALPEVEVNPETYEVRADGELLTCEPASVLPMAQRYFLF Kraken2_NZ_CP116420.1 IMICODJL_25383 Prodigal:2.6 11666 12841 + VFG048789(gb|WP_014838943) 67.7 1.79e-189 (ugd) UDP-glucose 6-dehydrogenase VF0560 Capsule VFC0258 Immune modulation The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. Assisting in evading the host immune system by protecting bacteria from opsonophagocytosis and serum killing MSKTKIAVVGIGYVGLSNAVLLALHNNVTAVDLNAERVAQVNARRAPIVDPEIEQYLAEKPLTLRATTDAEAAYREADYVLIATPTNYDPRTNVFDTSSVEAVVRDVLAVTKTATIVIKSTVPVGYTAGLSAELSSDQVIFSPEFLREGRALYDNLHPSRIVVGEDSPRARRFAQLLAEGAIADDIPMLFTGASEAEAVKLFANTFLAMRVAYFNELDSYALTNGLDTRQIIDGVCLDPRIGGHYNNPSFGYGGYCLPKDSKQLLANYSDVPQNLINAVVEANRTRKDFVSEQILALSPQRVGIYRLVMKAGSDNFRQSSVQGIMKRLKAKGIEVIVYEPVLQEERFFGSEVTRDLEAFKTRADVIVANRNHPDLADVPDKVFTRDLFGAD Kraken2_NZ_CP116420.1 IMICODJL_25385 Prodigal:2.6 13900 14544 - VFG006496(gb|WP_011115254) 60.9 2.4e-85 (ureG) urease accessory protein (ureG) VF0050 Urease VFC0282 Stress survival ~550kDa nickel metalloenzyme comprised of two distinct subunits-UreA and UreB, the UreEFGH proteins are required for activation of urease by incorporating nickel ions into the urease apoenzyme, UreI functions as an acid-dependent urea channel; PDB code: 1E9Z An important colonization factor, contributes to acid resistance, epithelial cell damage, chemotactic behavior, and nitrogen metabolism A Ni2+-containing enzyme, catalyzes the hydrolysis of urea to ammonium and carbon dioxide. Urea channels (UreI) present in the inner membrane are opened at pH<6.5, allowing delivery of urea to urease. The ammonia produced diffuses into, and thus buffers the periplasm. MKRNNGPLRVGIGGPVGAGKTTLTAALSRALRDRLSIGVITNDIYTQEDAEALMRMQVLPQDRIIGVETGGCPHTAIREDASINLAAVAEMVSRHPDVEVVLIESGGDNLSATFSPELADVTLYVIDVAAGEEIPRKGGPAITKSDILVINKTDLAPHVGASLEVMQRDSARMRPDLPTVFCALRSGEGIDTLLAHLAQVGGLDLTTMDPVSAA Kraken2_NZ_CP116420.1 IMICODJL_25388 Prodigal:2.6 15698 17422 - VFG006476(gb|WP_011115250) 63.9 3.4599999999999997e-262 (ureB) urease beta subunit UreB, urea amidohydrolase VF0050 Urease VFC0282 Stress survival ~550kDa nickel metalloenzyme comprised of two distinct subunits-UreA and UreB, the UreEFGH proteins are required for activation of urease by incorporating nickel ions into the urease apoenzyme, UreI functions as an acid-dependent urea channel; PDB code: 1E9Z An important colonization factor, contributes to acid resistance, epithelial cell damage, chemotactic behavior, and nitrogen metabolism A Ni2+-containing enzyme, catalyzes the hydrolysis of urea to ammonium and carbon dioxide. Urea channels (UreI) present in the inner membrane are opened at pH<6.5, allowing delivery of urea to urease. The ammonia produced diffuses into, and thus buffers the periplasm. MPAQIKRGDYAAMFGPTVGDRVRLADTDLIIEVERDLTTGEGRAYGEEVKFGGGKVIRDGMGQSQVTRAGGAVDTVITNALIVDYTGIYKADVGLKDGRIAKIGKAGNPDTQPGVDIIIGPGTEVIAGEGRILTAGGFDSHIHFICPQQIEDALHSGLTTMLGGGTGPAHGTLATTCTPGGWHIGRMMQAADAFPMNLAFAGKGNASQPAALEEQINAGACALKLHEDWGTTPAAIDCCLGVADAMDVQVMIHTDTLNESGFVEHTVKAMKGRTIHAFHTEGAGGGHAPDIIKICGEEHVLPSSTNPTRPFTVNTLEEHLDMLMVCHHLDKSIPEDVAFAESRIRRETIAAEDILHDMGAFSIIASDSQAMGRVGEVLIRTWQTADKMKKQRGRLPEETCDNDNFRVRRYIAKYTINPAIAHGISTHIGSIEEGKRADLVLWNPAFFGVKPEMVLLGGSIVCAQMGDPNASIPTPQPVYSRPMFGAYGRAVENSAVVFVSEAAEAAGVGGSLGLAKQTLAVRNTREIGKRDLKLNDALPEVEVNPETYEVRADGELLTCEPASVLPMAQRYFLF Kraken2_NZ_CP116421.1 IMICODJL_25669 Prodigal:2.6 92227 93267 + VFG007659(gb|WP_011261022) 62.2 3.13e-163 (rmlB) dTDP-glucose 4,6-dehydratase VF0624 Capsular polysaccharide VFC0258 Immune modulation MKILVTGGAGFIGSAVVRLAVARGHEVVNLDALTYAGCLENLASVADDPLYTFEHADIRDRAALDRILAAHQPDAVMHLAAESHVDRSIDGPGDFIETNITGTYNMLEAARSYWVAQGKPEGFRFHHISTDEVYGSLGAEGMFTEDTPYDPRSPYSASKASSDHLVRAWHETYGLPVVLTNCSNNYGPFHFPEKLVPVVILNALAGKPIPVYGEGLNVRDWLYVEDHADALLLVLEKGASGRCYNIGGENEARNIDLVKTICGILDQKRPKETPYADQITFVQDRAGHDLRYAIDPSRIRDELGWRPSVTVEKGLERTVQWYLDNEDWWRALQHRDGVGQRLGTKG Kraken2_NZ_CP116421.1 IMICODJL_25671 Prodigal:2.6 94120 94989 + VFG047033(gb|WP_012280623) 62.3 3.7699999999999995e-126 (wbtL) glucose-1-phosphate thymidylyltransferase VF0542 LPS VFC0258 Immune modulation The structure of Francisella spp. lipid A is unique in that it is modified by various carbohydrates that greatly reduce TLR4 activation and allow for immune evasion A key virulence factor does not signal through, and is not an agonist of, toll like receptor 4 (TLR-4) and has little endotoxic activity Francisella lipid A is a very poor stimulant of the host's innate immunity. The lack of immune recognition of Franciscella lipid A has been attributed to several structural differences compared to E. coli lipid A. These include (1) the absence of phosphate at the 40 position as well as the modification of 1-phosphate with GalN and (2) tetraacylation of lipid A with longer acyl chains (16–18 carbons); An unusual feature of the Francisella LPS core region is the presence of a single Kdo unit. Francisella initially synthesizes its LPS with two Kdo sugars and Kdo hydrolase is involved in removing the second, side-chain Kdo moiety. A probable scenario is the lack of an extra Kdo may alter the bacterial surface and result in decreased access of additional surface molecules to the host’s innate immune system MSKRKGIILAGGSGTRLYPITMGISKQLLPIYDKPMIYYPLSVLMLGGIRDIAMITTPQDQEQFIRTLGDGSQWGINLTYIVQENPDGLAQAYLLAEDFLAGAPSAMVLGDNIFFGHGLPDMLAAADERIEGGTVFGYHVSDPKRYGVVGFDADGIARKIIEKPDVPPSNYAVTGLYFLDGDAPKHAAEVKPSARGELEITSLLEMYLQAGTLQVERMGRGYAWLDTGTHGSLLDAGNFVRTLTERQGLQTGCLEEIAFKNGWISEEALAERAEMFTKNDYGSYLATLK Kraken2_NZ_CP116421.1 IMICODJL_25691 Prodigal:2.6 109547 110584 + VFG007659(gb|WP_011261022) 61.8 2.5500000000000003e-157 (rmlB) dTDP-glucose 4,6-dehydratase VF0624 Capsular polysaccharide VFC0258 Immune modulation MKLLVTGGAGFIGSAVVRLAIAQGHSVVNLDALTYAACLENVASVADSPLYAFEQSDIGDCAALDRIFADHQPDAVMHLAAESHVDRSIDGPGAFIQTNVTGTYTLLEAARAYWQGAGKPDSFRFHHISTDEVFGSLGPTGQFTETTPYDPRSPYSASKAASDHLVRAWGETYGLPIILTNCSNNYGPFHFPEKLVPVVILKALAEQPIPVYGDGANVRDWLYVEDHADALLTVLTKGTLGRSYNVGGENEVSNLELVKMICALLDDRRPKGAPHADLITFVADRPGHDKRYAIDPSRIRSELGWRPSVTVEEGLARTVDWYLANEDWWRALQNRSGVGDRLGTA Kraken2_NZ_CP116421.1 IMICODJL_25693 Prodigal:2.6 111454 112338 + VFG037938(gb|WP_000104825) 61.3 9.440000000000001e-122 (rfbA) glucose-1-phosphate thymidylyltransferase RfbA VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MTQNPKRKGIILAGGSGTRLYPITIAVSKQLLPIYNKPMIYYPLSVLMLGGIREIAIITTPQDADQFKRALGDGSQWGVSLTYITQPSPDGLAQAYLLAEDFLDGAPSAMVLGDNIFFGHGLPEILAAADAQETGGGTVFGYRVSDPERYGVVDFDEAGQARQIIEKPAVPPSNYAVTGLYFLDNSASERAKSVKPSARGELEITTLLETYLHDGLLNVQRMGRGYAWLDTGTHASLLDAGNFVRTLETRQGLQTGSPDEIAFNQGWISRAALTDRAEVFAKNEYGMYLGALSS Kraken2_NZ_CP116421.1 IMICODJL_25701 Prodigal:2.6 120775 121872 - VFG014103(gb|NP_251845) 65.2 2.01e-165 (wbpE) UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase VF0085 LPS VFC0258 Immune modulation Two distinct forms of LPS: A-band and B-band. A-band is a homopolymer of alpha-linked D-rhamnose, whereas B-band LPS is a heteropolymer Mediates biological effects including resistance to serum killing and phagocytosis; the binding to normal CFTR (cystic fibrosis transmembrane conductance regulator) and invasion of host cells may make a contribution to virulence in the human eye; internalization by binding to normal CFTR protein expressed by airway epithelial cells followed by desquamation of bacteria-laden epithelial cells, constitutes a host defense mechanism. If this mechanism fails to function properly, abnormally high bacterial carriage would promote the establishment of chronic bacterial infection Binding interaction occurs between the first extracellular loop of CFTR (predicted to be in amino acids 108-117 of the mature protein) and the complete outer portion of the core polysaccharide of the LPS MKFIDLGAQQDRLRSEIESGIARVLAHGKYIMGPEVTELEDALCDYTGAKYCISCANGTDALQIALMALGVGPGDEVITPGFSYIATAEAAVLLGARVVYVDIDPVTYNLNPALLEAAISPRTRAIIPVSLYGQTADFDAINAIAGRHGIPVIEDAAQSLGASYMGRKSGNLSTFACTSFFPTKPLGCYGDGGAIFTSDEVLAAAARQIARHGQAERYNHVRIGINSRLDTIQAAILLAKLSVLDDEIALREEVAGRYTAALADAVFQVPNIAKGSISAWAQYTVRVPDRDQVKVALSRQRIPTMVYYPAPLNKQPATATMEFSVTVGDTASLEVLSLPFSPYLSQADQDLVVTGLLEAIDTAAR Kraken2_NZ_CP116421.1 IMICODJL_25703 Prodigal:2.6 122446 123393 - VFG037913(gb|YP_001083150) 62.2 5.139999999999997e-128 (A1S_0053) MviM protein VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MTKQYALIGAAGYIAPRHLKAIKETEGNLAVAYDINDSVGIMDSHFPDAAFFTEFERFEAHVDNLRRAGQGIDYVGICSPNYLHKAHMGFALRSGADAICEKPLVLEVEDIDDLEDLEKATGQRINSILQLRLHPAIIALRDRIASGPKDKVYDVDLGYFTSRGAWYHASWKGFDQKSGGIATNIGVHFYDMLSFVFGPIRDNIVHHRGIDSAAGYLEFAQARVRWVLSINREHLPEHTSAGQTTHRSITVEGEEIEFSGGFTDLHTASYQNVLDGNGYGLNVVRPSIEVVSRIRTAPIEPNRGEHHPDIAKVLK Kraken2_NZ_CP116421.1 IMICODJL_25704 Prodigal:2.6 123406 124722 - VFG014099(gb|NP_251849) 64.4 3.79e-203 (wbpA) UDP-N-acetyl-d-glucosamine 6-dehydrogenase VF0085 LPS VFC0258 Immune modulation Two distinct forms of LPS: A-band and B-band. A-band is a homopolymer of alpha-linked D-rhamnose, whereas B-band LPS is a heteropolymer Mediates biological effects including resistance to serum killing and phagocytosis; the binding to normal CFTR (cystic fibrosis transmembrane conductance regulator) and invasion of host cells may make a contribution to virulence in the human eye; internalization by binding to normal CFTR protein expressed by airway epithelial cells followed by desquamation of bacteria-laden epithelial cells, constitutes a host defense mechanism. If this mechanism fails to function properly, abnormally high bacterial carriage would promote the establishment of chronic bacterial infection Binding interaction occurs between the first extracellular loop of CFTR (predicted to be in amino acids 108-117 of the mature protein) and the complete outer portion of the core polysaccharide of the LPS MGYARTFEEFASRVRDKQVVVGILGLGYVGIPLALSVARSELKVIGFDVLEDRVEELNAGRSPIKHISQDDIAGLRSAGFEATTDFSRAAECDALIICVPTPLNEYREPDLSYVVATMDTISPHLREGQLLSLESTTWPGTTKEVLLPYVEQAGLSVGENFFLVYSPEREDPGNASFETRTIPKVAGGHTAQCLKAAEALYGCFIDRVVAVSSTEAAEMVKLLENIHRSINIGLANEMKILADAMGLDIFEVIDAAKTKPFGFTAYYPGPGIGGHCIPIDPFYLTWKAREYGLHTRFIELAGEINASMPQYVVDKTVKALNACGKSLNGAKVLALGIAYKRDVDDMRESPSVFVMERLRDWGADVHYSDPNVPVFPEMREHSFDLRSVDLSPEVVAGYDAVILLTDHRGVDYEMIRQNAQLFVDTRGKFRGDAAVIRA Kraken2_NZ_CP116407.1 IMICODJL_26177 Prodigal:2.6 4852 5364 + VFG012491(gb|WP_001056957) 98.2 4.68e-129 (hlyC) Hemolysin C VF0225 Alpha-Hemolysin VFC0235 Exotoxin Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation; The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains Pro-HlyA is activated in the cytoplasm to the hemolytically active form by HlyC, a fatty acid acyltransferase; C-terminal peptide Trp914-Arg936 is a major receptor-binding region; the HlyA export machinery consists of two specific inner membrane (IM) proteins: HlyB, HlyD, and TolC, a multifunctional protein located in the outer membrane (OM); HlyB is inserted in the IM by eight hydrophobic alpha-helical transmembrane domains (TMDs). HlyD is a membrane of the membrane fusion protein (MFP) family. HlyD is anchored in the cytoplasmic membrane by a single TMD and possesses a large periplasmic domain within the C-terminal 100 amino acids Cytotoxic to many types of cells: erythrocytes, granulocytes, monocytes, endothelial cells and renal epithelial cells; stimulating the release of IL-1beta and TNF HlyA frist binds a receptor on the cell surface, a beta2-integrin in leukocytes or glycophorin in red blood cells, then becomes inserted in the cell membrane. Calcium binding to the glycine-rich repeats is essential for membrane lysis MNINKPLEILGHVSWLWASSPLHRNWPVSLFAINVLPAIRANQYALLTRDNYPVAYCSWANLSLENEIKYLNDVTSLVAEDWTSGDRKWFIDWIAPFGDNGALYKYMRKKFPDELFRAIRVDPKTHVGKVSEFHGGKIDKQLANKIFKQYHHELITEVKNKSDFNFSLTG Kraken2_NZ_CP116407.1 IMICODJL_26178 Prodigal:2.6 5376 8450 + VFG000906(gb|WP_001142375) 94.2 0.0 (hlyA) Hemolysin A VF0225 Alpha-Hemolysin VFC0235 Exotoxin Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation; The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains Pro-HlyA is activated in the cytoplasm to the hemolytically active form by HlyC, a fatty acid acyltransferase; C-terminal peptide Trp914-Arg936 is a major receptor-binding region; the HlyA export machinery consists of two specific inner membrane (IM) proteins: HlyB, HlyD, and TolC, a multifunctional protein located in the outer membrane (OM); HlyB is inserted in the IM by eight hydrophobic alpha-helical transmembrane domains (TMDs). HlyD is a membrane of the membrane fusion protein (MFP) family. HlyD is anchored in the cytoplasmic membrane by a single TMD and possesses a large periplasmic domain within the C-terminal 100 amino acids Cytotoxic to many types of cells: erythrocytes, granulocytes, monocytes, endothelial cells and renal epithelial cells; stimulating the release of IL-1beta and TNF HlyA frist binds a receptor on the cell surface, a beta2-integrin in leukocytes or glycophorin in red blood cells, then becomes inserted in the cell membrane. Calcium binding to the glycine-rich repeats is essential for membrane lysis MPTITTAQIKSTLQSTKQSAANKLHSAGQSTKDALKKAAEQTRNVGNRLILLIPKDYKGQGSSLNDLVRTADELGIEVQYDEKNGTAITKQVFGTAEKLIGLTERGVTIFAPQLDKLLQKYQKAGNKLGGSAENIGDNLGKAGSVLSTFQNFLGTALSSMKIDELIKKQKSGGNVSSSELAKASIELINQLVDTVASLNNNVNSFSQQLNKLGSLLSNTKHLNGVGNKLQNLPNLDNIGAGLDTVSGILSAISASFILSNADADTGTKAAAGVELTTKVLGNVGKGISQYIIAQRAAQGLSTSAAAAGLIASVVTLAISPLSFLSIADKFKRANKIEEYSQRFKKLGYDGDSLLAAFHKETGAIDASLTTISTVLASVSSGISAAATTSLVGAPVSALVGAVTGIISGILEASKQAMFEHVASKMADVIAEWEKKHGKNYFENGYDARHAAFLEDNFKILSQYNKEYSVERAVLITQQHWDTLIGELAGVTRNGDKTLSGKSYIDYYEEGKRLEKKTDEFQKQVFDPLKGNINLSDSKSSTLLKFVTPLLTPGEEIRERRQSGKYEYITELLVKGVDKWTVKGVQDKGSVYDYSNLIQHASVGNNQYREIRIESHLGDGDDKVFLSAGPANIYAGKGHDVVYYDKTDTGYLTIDGTKATEAGNYTVTRVLGGDVKVLQEVVKEQEVSVGKRTEKTQYRSYEFTHINGKNLTETDNLYSVEELIGTTRADKFFGSKFTDIFHGADGDDHIEGNDGNDRLYGDKGNDTLSGGNGDDQLYGGDGNDKLIGGAGNNYLNGGDGDDELQVQGNSLEKNVLSGGKGNDKLYGSEGADLLDGGEGNDLLKGGYGNDIYRYLSGYGHHIIDDDGGKEDKLSLADIDFRDVAFRREGNDLIMYKAEGNVLSIGHKNGITFRNWFEKESGDISNHQIEQIFDKDGRVITPDSLKKAFEYQQSNNKVSYVYGHDASTYGSQDNLNPLINEISKIISAAGNFDVKEERTAASLLQLSGNTSDFSYGRNSITLTASA Kraken2_NZ_CP116407.1 IMICODJL_26179 Prodigal:2.6 8522 10645 + VFG012478(gb|WP_000376544) 98.6 0.0 (hlyB) Hemolysin B VF0225 Alpha-Hemolysin VFC0235 Exotoxin Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation; The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains Pro-HlyA is activated in the cytoplasm to the hemolytically active form by HlyC, a fatty acid acyltransferase; C-terminal peptide Trp914-Arg936 is a major receptor-binding region; the HlyA export machinery consists of two specific inner membrane (IM) proteins: HlyB, HlyD, and TolC, a multifunctional protein located in the outer membrane (OM); HlyB is inserted in the IM by eight hydrophobic alpha-helical transmembrane domains (TMDs). HlyD is a membrane of the membrane fusion protein (MFP) family. HlyD is anchored in the cytoplasmic membrane by a single TMD and possesses a large periplasmic domain within the C-terminal 100 amino acids Cytotoxic to many types of cells: erythrocytes, granulocytes, monocytes, endothelial cells and renal epithelial cells; stimulating the release of IL-1beta and TNF HlyA frist binds a receptor on the cell surface, a beta2-integrin in leukocytes or glycophorin in red blood cells, then becomes inserted in the cell membrane. Calcium binding to the glycine-rich repeats is essential for membrane lysis MDSCHKIDYGLYALEILAQYHNISVNPEEIKHRFDTDGTGLGLTSWLLAAKSLELKVKQVKKTIDRLNFISLPALVWREDGRHFILTKVSKEANRYLIFDLEQRNPRVLEQSEFETLYQGHIVLIASRSSVTGKLAKFDFTWFIPAIIKYRKIFIETLVASVFLQLFALITPLFFQVVMDKVLVHRGGATLNVITVALSVVVVFEIILSGLRTYIFAHSTSRIDVELGAKLFRHLLALPISYFESRRVGDTVARVRELDQIRNFLTGQALTSVLDLLFSFIFFAVMWYYSPKLTLVILFSLPCYAAWSVFISPILRRRLDDKFSRNADNQSFLVESVTAINTIKAMAASPQMTNIWDKQLAGYVAAGFKVTVLATIGQQGIQLIQKTVMIINLWLGAHLVISGDLSIGQLIAFNMLAGQIVSPVIRLAQIWQDFQQVGISVTRLGDVLNSPTESYHGKLALPEINGDITFRNIRFRYKPDSPVILDNINLSIKQGEVIGIVGRSGSGKSTLTKLIQRFYIPENGQVLIDGHDIALADPNWLRRQVGVVLQDNVLLNRSIIDNISLANPGMSVEKVIYAAKLAGAHDFISELREGYNTIVGEQGAGLSGGQRQRIAIARALVNNPKILIFDEATSALDYESEHVIMRNMHKICKGRTVIIIAHRLSTVKNADRIIVMEKGKVVEQGKHKELLSEPESLYSYLYQLQSD Kraken2_NZ_CP116407.1 IMICODJL_26180 Prodigal:2.6 10664 12100 + VFG012472(gb|WP_000860470) 98.3 1.51e-318 (hlyD) Hemolysin D VF0225 Alpha-Hemolysin VFC0235 Exotoxin Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation; The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains Pro-HlyA is activated in the cytoplasm to the hemolytically active form by HlyC, a fatty acid acyltransferase; C-terminal peptide Trp914-Arg936 is a major receptor-binding region; the HlyA export machinery consists of two specific inner membrane (IM) proteins: HlyB, HlyD, and TolC, a multifunctional protein located in the outer membrane (OM); HlyB is inserted in the IM by eight hydrophobic alpha-helical transmembrane domains (TMDs). HlyD is a membrane of the membrane fusion protein (MFP) family. HlyD is anchored in the cytoplasmic membrane by a single TMD and possesses a large periplasmic domain within the C-terminal 100 amino acids Cytotoxic to many types of cells: erythrocytes, granulocytes, monocytes, endothelial cells and renal epithelial cells; stimulating the release of IL-1beta and TNF HlyA frist binds a receptor on the cell surface, a beta2-integrin in leukocytes or glycophorin in red blood cells, then becomes inserted in the cell membrane. Calcium binding to the glycine-rich repeats is essential for membrane lysis MKTWLMGFSEFLLRYKLVWSETWKIRKQLDTPVREKDENEFLPAHLELIETPVSRRPRLVAYFIMGFLVIAFILSVLGQVEIVATANGKLTLSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTILARINRYENLSRIEKSRLDDFRSLLHKQAIAKHAVLEQENKYVEAANELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDSIELLTLELEKNEERQQASVIRAPVSGKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVENKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINLDAIEDQKLGLVFNVIVSVEENGLSTGNKNIPLSSGMAVTAEIKTGIRSVISYLLSPLEESVTESLRER Kraken2_NZ_CP116408.1 IMICODJL_26310 Prodigal:2.6 51217 51702 - VFG014116(gb|NP_251832) 64.8 1.7800000000000002e-35 (PA3142) hypothetical protein VF0085 LPS VFC0258 Immune modulation Two distinct forms of LPS: A-band and B-band. A-band is a homopolymer of alpha-linked D-rhamnose, whereas B-band LPS is a heteropolymer Mediates biological effects including resistance to serum killing and phagocytosis; the binding to normal CFTR (cystic fibrosis transmembrane conductance regulator) and invasion of host cells may make a contribution to virulence in the human eye; internalization by binding to normal CFTR protein expressed by airway epithelial cells followed by desquamation of bacteria-laden epithelial cells, constitutes a host defense mechanism. If this mechanism fails to function properly, abnormally high bacterial carriage would promote the establishment of chronic bacterial infection Binding interaction occurs between the first extracellular loop of CFTR (predicted to be in amino acids 108-117 of the mature protein) and the complete outer portion of the core polysaccharide of the LPS MDALSTGRRIKCLTCVDDFTKECLTVTVAFGISGVQVTRILDSIALFRGYPATIRTDQGPEFTCRALDQWAFEHGVELRLIQPGKPTQNGFIESFNGRFRDECLNEHWFSDIVHARKIINDWRQDYNECRPHSTLNYQTPSEFAAGWRKGHSENEDSDVTN Kraken2_NZ_CP116400.1 IMICODJL_26380 Prodigal:2.6 40606 41724 - VFG002182(gb|WP_002376666) 61.7 4.28e-176 (cpsI) UDP-galactopyranose mutase VF0361 Capsule VFC0258 Immune modulation The biosynthesis of capsular polysaccharides by E. faecalis is encoded by the csp operon, which includes 11 open reading frames (cpsA to cpsK). However, only 7 open reading frames in the cps operon are essential for capsule production (cpsC, cpsD, cpsE, cpsG, cpsI, cpsJ, and cpsK); Previous genetic evidence demonstrated that E. faecalis isolates can be classified in 1 of 3 capsule operon polymorphisms. CPS 1 presents only cpsA and cpsB. CPS 2 presents all 11 genes in the cps operon. CPS 5 presents all genes except for cpsF. Furthermore, CPS 2 and 5 express the capsular polysaccharide, whereas CPS 1 does not. Contributes to host immune evasion Masks bound C3 from detection on the surface of E. faecalis; masks lipoteichoic acid from detection MKAYDYLVVGAGLFGAVFAHEAALRGKKIKVIEKRDHIAGNIYTHEVDGIQVHQYGAHIFHTSDKQIWDYVNQFATFNRYTNSPVANYKGKMYNLPFNMNTFNELWGTKTPQEAMNKIAEQKSAAKITDQPKNLEEQAISLVGTDIYQKLVKGYTEKQWGQKATDLPAFIIRRLPVRYTYDNNYFNDTYQGIPIGGYTQIVEKMLDHPQIDVKTGVDFFGNKEKYLKDYPRVIFTGMIDQYFNYQLGELEYRSLRFESEELSVDNYQGNAVVNYTDAETPFTRIIEHKHFEFGKGDKNKTVITREYPVDWKRGDEPYYPVNNKRNNGLYKQYTELAKQEGNVVFGGRLGQYRYYDMHQVIHAALLAVEYELG Kraken2_NZ_CP116400.1 IMICODJL_26436 Prodigal:2.6 90103 91221 - VFG002182(gb|WP_002376666) 61.7 4.28e-176 (cpsI) UDP-galactopyranose mutase VF0361 Capsule VFC0258 Immune modulation The biosynthesis of capsular polysaccharides by E. faecalis is encoded by the csp operon, which includes 11 open reading frames (cpsA to cpsK). However, only 7 open reading frames in the cps operon are essential for capsule production (cpsC, cpsD, cpsE, cpsG, cpsI, cpsJ, and cpsK); Previous genetic evidence demonstrated that E. faecalis isolates can be classified in 1 of 3 capsule operon polymorphisms. CPS 1 presents only cpsA and cpsB. CPS 2 presents all 11 genes in the cps operon. CPS 5 presents all genes except for cpsF. Furthermore, CPS 2 and 5 express the capsular polysaccharide, whereas CPS 1 does not. Contributes to host immune evasion Masks bound C3 from detection on the surface of E. faecalis; masks lipoteichoic acid from detection MKAYDYLVVGAGLFGAVFAHEAALRGKKIKVIEKRDHIAGNIYTHEVDGIQVHQYGAHIFHTSDKQIWDYVNQFATFNRYTNSPVANYKGKMYNLPFNMNTFNELWGTKTPQEAMNKIAEQKSAAKITDQPKNLEEQAISLVGTDIYQKLVKGYTEKQWGQKATDLPAFIIRRLPVRYTYDNNYFNDTYQGIPIGGYTQIVEKMLDHPQIDVKTGVDFFGNKEKYLKDYPRVIFTGMIDQYFNYQLGELEYRSLRFESEELSVDNYQGNAVVNYTDAETPFTRIIEHKHFEFGKGDKNKTVITREYPVDWKRGDEPYYPVNNKRNNGLYKQYTELAKQEGNVVFGGRLGQYRYYDMHQVIHAALLAVEYELG Kraken2_NZ_CP116410.1 IMICODJL_26549 Prodigal:2.6 1 3507 + VFG036084(gb|WP_001020413) 99.7 1.28e-271 (senB) enterotoxin production-related protein TieB VF1136 Enterotoxin SenB/TieB VFC0235 Exotoxin MNVIKLAIGSGILLLSCGAYSQSISEKTNSDKKGAAEFSPLSVSVGKTTSEQEALEKTGATSSRTTDKNLQSLDATVRSMPGTYTQIDPGQGAISVNIRGMSGFGRVNTMVDGITQSFYGTSTSGTTTHGSTNNMAGVLIDPNLLVAVDVTRGDSSGSEGINALAGSANMRTIGVDDVIFNGNTYGLRSRFSVGSNGLGRSGMMALGGKSDAFTDTGSIGVMAAVSGSSVYSNFSNGSGINSKEFGYDKYMKQNPKSQLYKMDIRPDEFNSFELSARTYENKFTRRDITSDDYYIKYHYTPFSELIDFNVTASTSRGNQKYRDGSLYTFYKTSAQNRSDALDINNTSRFTVADNDLEFMLGSKLMRTRYDRTIHSAAGDPKANQESIENNPFAPSGQQDISALYTGLKVTRGIWEADFNLNYTRNRITGYKPACDSRVICVPQGSYDIDDKEGGFNPSVQLSAQVTPWLQPFIGYSKSMRAPNIQEMFFSNSGGASMNPFLKPERAETWQAGFNIDTRDLLVEQDALRFKALAYRSRIQNYIYSESYLVCSGGRKCSLPEVIGNGWEGISDEYSDNMYIYVNSASDVIAKGFELEMDYDAGFAFGRLSFSQQQTDQPTSIASTHFGAGDITELPRKYMTLDTGVRFFDNALTLGTIIKYTGKARRLSPDFEQDEHTGAIIKQDLPQIPTIIDLYGTYEYNRNLTLKLSVQNLMNRDYSEALNKLNMMPGLGDENPPSQFRAWQNMDIWRGHSFLMTISARFRQYVFSLMSILLQERKMNIFTLSKAPLYLLISLFLPTMAMAIDPPERELSRFALKTNYLQSPDEGVYELAFDNASKKVFAAVTDRVNREANKGYLYSFNSDSLKVENKYTMPYRAFSLAINQDKHQLYIGHTQSASLRISMFDTPTGKLVRTSDRLSFKAANAADSRFEHFRHMVYSQDSDTLFVSYSNMLKTAEGMKPLHKLLMLDGTTLALKGEVKDAYKGTAYGLTMDEKTQKIYVGGRDYINEIDAKNQTLLRTIPLKDPEPQITSVQNLAVDSASDRAFVVVFDHDDRSGTKDGLYIFDLRDGKQLGYVHTGAGANAVKYNPKYNELYVTNFTSGTISVVDATKYSITREFNMPVYPNQMVLSDDMDTLYIGIKEGFNRDWDPDVFVEGAKERILSIDLKKS Kraken2_NZ_CP116410.1 IMICODJL_26625 Prodigal:2.6 59424 60005 - VFG001445(gb|AAA92657) 97.4 5.690000000000003e-109 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MCALDCRERPLNSQSVNKYILNVQNIYRNSPVPVCVRNKNRKILYANGAFIELFSREDKPLSGESYIRLQVEIFLSSLELECQALGHGSAFCRRFNFHGEIYQIRMENVSFYNDESVVLWQINPFPDYPFFALNQSGSNTNTSDKLTIWNDFLQGHWLFSLFICWVLVTQQLPESWVLQTEHLRIELNQLNGK Kraken2_NZ_CP074490.1 IMICODJL_26703 Prodigal:2.6 3252 4817 + VFG044066(gb|WP_000447001) 88.5 4.79e-258 (ECSMS35_RS25765) colicin-like pore-forming protein VF1182 Colicin E1 VFC0235 Exotoxin METAVAYYKDGVPYDDKGQVIITLLNGNPDGSGSGGGGGTGGSKSESSAAIHATAKWSTAQLKKTQAEQAARAKAAAEAQAKAKANRDALTQHLKDIVNEALRHNSTHPEVIDLAHANNAAMQAEAERLRLAKAEEKARKEAEAAEKAFQEAEQRRKEIEKEQAETERQLKLAEDEEKRLAALSEEARAVEVAQKNLAAAQSELAKVDEEINTLNTRLSSSIHARDAETNTLSGKRNELDQASAKYKELDERVKLLSPRANDPLQSRPFFEATRLRARAGDEMEEKQKQVTASETRLNQISSEINGIQEAISQANNKRSTAVSRIHDAEDNLKTAQTNLLNSQIKDAVDATVSFYQTLSEKYGEKYSKMAQELADKSKGKKISNVNEALAAFEKYKDVLNKKFSKADRDAIFNALEAVKYEDWAKHLDQFAKYLKITGHVSFGYDVVSDILKIKDTGDWKPLFLTLEKKAVDAGVSYVVVLLFSVLAGTTLGIWGIAIVTGILCAFIDKNKLNTINEVLGI Kraken2_NZ_CP064407.1 IMICODJL_26843 Prodigal:2.6 45815 47905 - VFG042984(gb|ACI49668) 99.9 0.0 (ACI49668) minor pilin subunit VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MNFKHSWTRRLKYVFPIMMMLGTLFGLKTANVFAEKVIVDPSNPIQNVKNNFIIPKDVPNAKTNITVNGASKVYKYHVDANKGGFTDDYVGLVEGNKNIRYPSFQKEYGETNLVLEGVTTNTKVNIDFGKIGTYNGKKVNIKLVLSNIHLYSDTLPWNLLDNNYTKTHFRDDGYKNTNGAMSKSKKRTVLWISDNLFSGIVYHSTQMNVQLVATYEDGSPVQFSGDTFISFNSLNPAGGKSTDLKGEYAHYDKMNTTDWYVRKDTVLSEFKSFYNNLNVVGGHPGGSSKLTQADNDFNNLHDKLGDPKFGQGTVSFKISEANPTFVIGSSNVQTWFTLSSATIFSVVPDQPEKTGVDKNGNNVNDKMLQVGDTIQYRIKQKVNRLGVDLLAVYDRFELIDNLPKEVNYVDAHVESGTNKKFDVSGEVTYDKTKHQVKYAAKADTLKNRMKYNGETYELVINVKVNELANQNSVAKNQGTSIINKVEKDTNIITVYFPKIPVKEVQQNGKDVNGRNDGKKGTPTAPLNAGSEVQYLVTQKWHTKGVDAASDHYKQFSIQDPIEARLTYKEGSAQVIDKSKGKDITSEGTLTYDSNSRTLKWEASADFLSNNLLDGREIQLIFTAKTPLQSEKNIDNQAVVAVDNVSNKTNVVTIGVDPNLPQVIVPKTGSTHLVTISAVSLLLLVLATFSYAVLRYI Kraken2_NZ_CP064407.1 IMICODJL_26844 Prodigal:2.6 47902 48162 - VFG042985(gb|ACI49669) 97.7 8.78e-49 (ACI49669) hypothetical hydrophobic peptide VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKLIKLLLFNLSCLTAVFLYCGLLFSKLSILPSYQLYLMRILNIPAASMPLDIMEKLIRNPLFTTINLIVIVGISLVIYKKEGMKG Kraken2_NZ_CP064407.1 IMICODJL_26845 Prodigal:2.6 48175 48930 - VFG042986(gb|ACI49673) 99.6 1.9600000000000003e-161 (ACI49673) cell wall-associated LPXTG-like protein VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MRNRKWLFVCAAALFSFTAYTQLTFADRQESTDSTEQTIQTSDSSTIQSSDETVDSSTVDSSEEPKIAEDGQIVKQTIHVQKIISSEQLDNQGHEKQEGVNGAKFSVYDVSDILQKMDVKDLTTDQIESQLKDRVKKLSSDQLKLVSNGETKTIDQQTGVFEFSVEVQANQKQAYYIVNESSPENISNSEDILLLTPVSDKNGEFLKDVWIYPKSEASQPKEEVKKIVSTGVKKNFFENCWDFVTHLFSRD Kraken2_NZ_CP064407.1 IMICODJL_26846 Prodigal:2.6 48946 49698 - VFG042987(gb|ACI49670) 98.4 6.0199999999999995e-176 (ACI49670) putative pilus-dedicated sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MIIRKPKKKRIMGKWIIAFWLLSAVGVLLLMPAEASVAKYQQNQQIAAIDRTGRAAETDSSLDVAKIELGDPVGILTIPSISLKLPIYDGMSDKILENGVGITEGTGDITGGNGKNPLIAGHSGLYKDNLFDDLPSVKKGEKFYIKVDGEQHAYQIDRIEEVQKDELQRNFVTYLEPNPNEDRVTLMTCTPKGINTHRFLVYGKRVTFTKSELKDEENKQQKLSWKWLLGSTVFLSVMIIGSLFVYKKKK Kraken2_NZ_CP064407.1 IMICODJL_26847 Prodigal:2.6 49713 51689 - VFG042988(gb|ACI49671) 98.5 0.0 (pilA) PilA VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MAINRYVKKAGMLVGMLGIIASCFQGYQAYAEDVTQKTPPEKVNITVHKLMYDQGTQLNVDIDGIKNDGYTHDQYPTGVTKYNKADYGDVEFTLGNITDQVLPTEDSDLTNAKVDEIVKDVEDKGSNSEYVKNATNKITSAVDENGEITFADQPAYVNSKGNVYVVYESKSAAGLVTQKAKPMVVIAPMTDNTGSGFLKDIHLYPKNIVSKLSFELTKFGDDGTAQSKQTPLKGAKFELYKGEPGKGTKLGDLVSDDQGKLTATDLTLGKYYFVEVPSEVVVGSGKEPTADQYLLGADARNDAHNKLTFEITNDGVTSDLKASYVNYKAPVIDKTVTNGTGQEHSFQIGDAVNYQGTIHIPTDIAGGADGITVNGVKSETSLYSVFKWGDTAGQGLSYVAAKANIKVTNKDGSVVLKENTDYKIQNSENGFVIDFIVNNGQVSDTVASLHGQDLQMTYNMYVNDSAAVANPLTNSVDFVYNNNPFNQEEHHEKTKADVVTYGAKFLKVDSGLFGTGIKATPLEGAEFAAKNAEGKYYGGLVDTDKDGVKEAVWVDDVANAAILKSDKEGHFEITGLTEGKYSLEETKAPENYQKLTKEISFKVDKDSYKEENRITIKNNQKASVPMTGSNGFQTYVLISCLLLGAGALSAVAYFKKKA Kraken2_NZ_CP064407.1 IMICODJL_26848 Prodigal:2.6 51742 52413 - VFG042989(gb|ACI49672) 99.1 1.27e-159 (ACI49672) putative housekeeping sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKKWLFGFLGVALIVFCSVFGYVSYQKHEGEVFKQNIEKKMPVDQINAHAKSYKEDATNVNNDMSLGQMLSIQKEAIKMGVNKQVFAQIQIPALGLAFPIFKGANQYTLSLGAATYFYEDAEMGKGNYVLAGHNMEMPGVLFSDIQKLSLGEVMDLVSNDGVYRYKVTRKFIVPEYFKLIDGVPEENSFLSLPKKGEKPLLTLFTCVYTSQGKERYVVQGELQ Kraken2_NZ_CP064408.1 IMICODJL_27005 Prodigal:2.6 28990 32247 + VFG042994(gb|AAZ68037) 97.3 0.0 (bee1) Bee1 VF0746 Bee (biofilm enhancer in enterococci) VFC0001 Adherence MKKKKSVWFMMVAILMGFIPQILTAYSSIAQAIETQPDKIVDQSGLKVSSSVSSDGNSLNWKLQYEKDVASDGNDQALKFKVTADGEAIAFNEDASFATNDDQWFAEKDFSKQSQGSLSFTTVLNVSKVALEIQADATKTDETQAVTINKNILTSAVEGPHALKLPAVATQKTTEVSATSQTTAEETTSSQATETTTQTEEASEATEGTIQTSDDSTMVGPQQNYYRSSAASTYDVSAYNDPFKYTPDGGQYPSHDTNQYTKSDSSDMIKNYNYGSAGDSDSNVEIQNILEGNLNFDNGYHAYDVGNNQNINLKKIVIPTDNPTQFQIQLDIIGGALKARKNVDVAFVVDKSGSMATNNRWNNLKSALNTFAHGLLDDNPGGSVQLGIAGFSSVQETITYSPYYNYKINVPYGKVGNFGGTQGNYTGFTTSADAFLNHALLNESPSGGTPTFLGLDAGLELLTNSQYNGRKDAQKVLIILTDGLPTWGPTTTYTSSSSRIRQSGMTRSSDNNGRVETFKATNTTLYIGNGSETGPDISTVRSNTISHGKKRTEQNPEIDRYAIGFGVTDVNDILDALGPQGKYSATSHTDLNYVLNQIKKKIQDVNALIRNANVFDPMSKYVALDTSSVKTQALTLKTSSPKSLNVTTGTQPDYVNGVTVDTRNNSVNLSNLTLSGNDTQRDGLRVTYTVSLKEEYQDGKFYPANGPTYLADNQYKDQFGFAVPSVKVPPQKFDIEAEKIWDDEDNQWGTRKEVTLQLQQKSGNENWANISGKTITIKANATGDSLKGKFSDVPAYDSSKNVLEYRVVEERVNGYEEASYSPTSINVNSDKKLLQVTNKLLKTSVTFTKVGNDGKTPLAGAGFTLYKADGTTAIGKEVTSDDNGQVTFDIELPIGKYVIKETTTPLGYETQDPIEIMIADADGKLTVSGIKDNQVVNLLKDFELIVTKKDILGKDLKGAKFKLVGKDYSKELDSDTNVFKFTGLKPGEYELIETVAPHGYVGLKDSIKIVIDQDGKVTIDGKEQKDVITTDGNVIKYNVANQQKGLLPSTGGQGIRHLMEFALLVIGLSALVGGIYVYRNRKELN Kraken2_NZ_CP064408.1 IMICODJL_27006 Prodigal:2.6 32249 32980 + VFG042995(gb|AAZ68038) 96.3 9.36e-156 (bee2) Bee2 VF0746 Bee (biofilm enhancer in enterococci) VFC0001 Adherence MKNKSLFIKITLLLSTLLVGIFTGKQAFADDGTIDIVIHKQLWDQAPDVTIQNTGAADQDTKDSIEGVGFTIYDITEDYYKLVKGSDETTTIRMIQENVADYQKIIREQGLTDEKGTIKFIQLPKSSGGKNAVYLIVETVLPDPEKVKVEKAAEPLVVALPVYEMSTDGKTYTDKELATVHLYPKNVGTIVEKPVTPTKPKKPSKPKKRLPQTGEAKSFLGILGILLIGTAIILWRKHSVRNN Kraken2_NZ_CP064408.1 IMICODJL_27007 Prodigal:2.6 33045 34520 + VFG042996(gb|AAZ68039) 97.3 0.0 (bee3) Bee3 VF0746 Bee (biofilm enhancer in enterococci) VFC0001 Adherence MKKLWKTLFSALLVVPLFTSVFGAITVSAAEATTTNVTINKRIWKDGEAPAQGSMQNTGEEMDFGGAPLKGAGFTAYDVTDAYLALIADGKKSQAEATKEIADNASNYTTVAKTEQKTDAKGQTTFEGLALKDGDKDKVYMFVETSTPGNVSVTTKAAPIVLAMPIYTFKDGKYSDTINTNVQVYPKNETKTDKKEVANLDKFTEVKGADGNVLYHNLTTGDEIEYKLTLNIPADILEDGVTYSVTDTPTAGLAYVKDSFAATGLVAGTDYELAEDSATGGFTVTLKQSENVGKLAGSQLIATYKMKLTAEVNPDDLVNNSAQVTIGNNPQDKITPPTQFGTGGYKFVKKDSQSGATLSGAEFVVKQGSNFAIFEDAKNTKGEYIFKEWATDEAKATKIVSDDKGELKVIGLKNGDYQLEEKATSSDKYVLLDEDVDFTVEHGQYGSQELKSVLNTPKGLLPSTGGNGIYAFLLIGAALMIDRCLRLVQEI Kraken2_NZ_CP064408.1 IMICODJL_27008 Prodigal:2.6 34625 35821 + VFG042997(gb|AAZ68040) 99.7 2.3e-284 (srt1) Srt1 VF0746 Bee (biofilm enhancer in enterococci) VFC0001 Adherence MDQRQKNERINLILKLLMAILFTTGAIIFSYPFLANAVNSYYDQKMMEKNLAEMAATNTKEQAKRHQEMAEKNKELAESKNMTNIPGMGLVEDPFENEVDDAKDPGKAYYKEHTVGAIYIPKISVSLPLFDETNAALLEKGATILQGTSYPIGGDSTHSVISGHSGLTERKLFTDLEKLVIGDDFYLTIAGEKLAYAVDDIQIVLPSDIDKVVIQPGRDLVTLLTCTPYGINTHRLLVTGHRVPYVEEMAEEVTSTKKAVERRFRLYLLLIPLFFAMIFYWMYRKFVYYQSGKHSYDFCFYLLENGQPKAGVTFTLVRKKRWATDVTNQPVAVSQVDGWVSFPEIRGGRYYAKAIDGSTKPVKGKVRRLKDRQFVLSRVTKKKQGKKVTYYLENGAKK Kraken2_NZ_CP064408.1 IMICODJL_27009 Prodigal:2.6 35818 36939 + VFG042998(gb|AAZ68041) 99.5 2.4899999999999997e-264 (srt2) Srt2 VF0746 Bee (biofilm enhancer in enterococci) VFC0001 Adherence MKKNRQVISQIAIILIFMVGVLTMLYPFYVDALNNVIDQVRVDRYLKESQKEFEAERKRLAEENSKLSESGLAPGADPFANPNGGTVTAAYYKKHLIGTINLPDLAIELPLFDTTNDDLLEQGATVLDGTSFPVGGASTHAVISAHRGLPERELFTNLPELKNGDIFLLNVLGETLAYEVFDSQVVTPDQTSVLKIEPGQDLVTLMTCTPYMINSHRLLVTGKRVPYTPAAEKKQVKGDRFRKLKQIAILAGTALLILAAIYQLYHVIARYRLRKVRFDFTVCLEGVAEHTPITLYDKKGKKALRRNGKAYQELTDQTGQVTFTDLPGDCYRLKLGKSWLVQFGLKKKKRPSKIWKINKKKVMLKEEGILEVK Kraken2_NZ_CP064425.1 IMICODJL_27107 Prodigal:2.6 5910 6581 + VFG042989(gb|ACI49672) 98.7 2.11e-158 (ACI49672) putative housekeeping sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKKWLFGFLGVALIVVCSVFGYVSYQKHEGEVFKQNIEKKMPVDQINAHAKSYKEDATNVNNDMSLGQMLSIQKEAIEMGVNKQVFAQIQIPALGLALPIFKGANQYTLSLGAATYFYEDAEMGKGNYVLAGHNMEMPGVLFSDIQKLSLGEVMDLVSNDGVYRYKVTRKFIVPGYFRLIDGVPEENSFLSLPKKGEKPLLTLFTCVYTSQGKERYVVQGELQ Kraken2_NZ_CP064425.1 IMICODJL_27108 Prodigal:2.6 6633 8609 + VFG042988(gb|ACI49671) 97.6 0.0 (pilA) PilA VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MAINRYVKKAGMLVGMLGIIASCFQGYQAHAEDVTQKTPPEKVNITVHKLMYDQSTQLNVDIDGIKNDGYTHDQYPTGVTKYNKADYGDVEFTLGNITDQVLPTEDSDLTNAKVDEIVKDVEDKGSNSEYVKNATNKITSAVDENGEITFADQPAYVNSKGNVYVIYESKSAAGLVTQKAKPMVVIAPMTDNTGSGFLKDIHLYPKNIVSKLSFELTKFGDDGTEQSKQTPLKGAKFELYKGEPGKGSKLGDLVSDDQGKLTATDLTLGKYYFVEVPSEVVVGSDKEPTADQYLLGADARNDAHNKLTFEITNDGVTSDLKASYVNYKAPVIDKTVTNGTGQEHSFQVGDAVNYQGTIHIPTDIAGGADGITVNGVKSETSPYSVFKWGDTAGQGLSYVAAKANIKVTNKDGSVVLKENTDYKIQNSENGFVIDFIVNNGQVSDTVASLHGQDLQMTYNMYVNDSAAVANPLTNSVDFVYNNNPFNQEEHHEKTKADVVTYGAKFLKVDSGLFGTGIKATPLEGAEFAAKNAEGKYYGGLTDTDKDGVKEAVWVDDVANAAILKSDKEGHFEITGLTEGDYSLEETKAPENYQKLTKEISFKVDKDSYKEENRITIKNNQKASVPMTGSNGFQSYVLISCLLLGAGAISAVVYFKKKA Kraken2_NZ_CP064425.1 IMICODJL_27109 Prodigal:2.6 8622 9374 + VFG042987(gb|ACI49670) 98.8 1.8e-177 (ACI49670) putative pilus-dedicated sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MIIRHPKKKRIMGKWIIAFWLLSAVGVLLLMPAEASVAKYQQNQQIAAIDRTGTAAETDSSLDVSKIELGDPVGILTIPSISLKLPIYDGTSDKILENGVGITEGTGDITGGNGKNPLIAGHSGLYKDNLFDDLPSVKKGEKFYIKVDGEQHAYQIDRIEEVQKDELQRNFVTYLEPNPNEDRVTLMTCTPKGINTHRFLVYGKRVTFTKSELKDEENKKQKLSWKWLLGSTVFLSVMIIGSLFVYKKKK Kraken2_NZ_CP064425.1 IMICODJL_27110 Prodigal:2.6 9390 10145 + VFG042986(gb|ACI49673) 96.4 2.98e-156 (ACI49673) cell wall-associated LPXTG-like protein VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MRNRKWLFVCAAALFSFTAYTQLTFADSQESTDSTEQTIQTSDSSTIQSSDETVDSSTVDSSEEPKIAEDDQIVKQTIHVQKIISSEQLDNQGHEKQEGVNGAKFSVYDVSDILQKMDVKDLTTDQIESQLKDRVKKLSSDQLKLVSNGETKTIDQQTGVFEFSVEVQANQKQAYYIVNESSPENISNSEDILLLTPVSEKNGEFLKDVWIYPKSEASQPKEEVKKIVSTGVKKNFFENCWDFVTHLFSRD Kraken2_NZ_CP064425.1 IMICODJL_27111 Prodigal:2.6 10158 10418 + VFG042985(gb|ACI49669) 98.8 2.15e-49 (ACI49669) hypothetical hydrophobic peptide VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKLIKLLLFNLSCLTAVFLYCGLLFSQLSILPSYQLYLMRILNIPAASMPLDIMEKLIRNPLFTTINLIVIVGISLVIYKKEGMKG Kraken2_NZ_CP064425.1 IMICODJL_27112 Prodigal:2.6 10415 12505 + VFG042984(gb|ACI49668) 98.1 0.0 (ACI49668) minor pilin subunit VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MNFKHSWTRRLKYVFPIMMMLGTLFGLKTANVFAEKVIVDPSNPIQNVKNNFIIPKDVPNAKTNITVNGASKVYKYHVDANKGGFTDDYVGLVEGNKNIRYPSFQKEYGETNLVLEGVTTNTKVNIDYGKIGTYNGKKVNIKLVLSNIHLYSDTLPWNLLDNNYTKTHFRDDGYKNTNGAMSKSKKRTVLWISDNLFSGIVYHSTQMNVQLVATYEDGSPVQFSGDTFISFNSLNPAGGKSTDLKGEYAHYDKMNTTDWYVRQDAVLSEFKSFYNNLNVVGGHPGGSSKLTQADNDFNNLHDKLGDPKFGQGTVSFKISEANPTFVIGSSNVQTWFTLSSATIFSVVPDQPEKTGVDKNGNNVNDKMLQVGDTIQYRIKQKVNRLGVDLLAVYDRFELIDNLPKEVDYVDAHVESGTNKKFDVSGEVTYDKTKHQVKYAAKADTLKNRMKYNGETYELVINVKVNELANQNSVAKNQGTSIINKVEKDTNIITVYFPKIPVKEVQQNGKDVNGRNDGKKGTPTAPLNAGSEVQYLVTQKWHTKGVDAASDHYKQFSIQDPIEARLTYNDGSAQVIDKSTGKDITSEGTLTYDSNSRTLKWEASADFLNNNLLDGREIQLIFTAKTPLQSEKNIDNQAVVAVDNVSNKTNVVTIGVDPNLPQVIVPKTGSTHLVTILAVSLLLLVLATFGYAVLKFN Kraken2_NZ_CP064427.1 IMICODJL_27432 Prodigal:2.6 10152 11222 - VFG042984(gb|ACI49668) 97.6 1.42e-238 (ACI49668) minor pilin subunit VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MDQTVKICFSHNDDVRYIVWVKTANVFAEKVIVDPSNPIQNVKNNFIIPKDVPNAKTNITVNGASKVYKYHVDANKGGFTDDYVGLVEGNKNIRYPSFQKEYGETNLVLEGVTTNTKVNIDYGKIGTYNGKKVNIKLVLSNIHLYSDTLPWNLLDNNYTKTHFRDDGYKNTNGAMSKSKKRTVLWISDNLFSGIVYHSTQMNVQLVATYEDGSPVQFSGDTFISFNSLNPAGGKSTDLKGEYAHYDKMNTTDWYVRQDAVLSEFKSFYNNLNVVGGHPGGSSKLTQADNDFNNLHDKLGDPKFGQGTVSFKISEANPTFVIGSSNVQTWFTLSSATIFSVVPDQPEKQGLIKMEIT Kraken2_NZ_CP064427.1 IMICODJL_27433 Prodigal:2.6 11645 12235 - VFG042986(gb|ACI49673) 93.0 1.25e-101 (ACI49673) cell wall-associated LPXTG-like protein VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MQPLFFSFTAYTQLTFADSQESTDSTEQTIQTSDSSTIQSSDETVDSSTVDSSEEPKIAEDDQIVKQTIHVQKIISSEQLDNQGHEKQEGVNGAKFSVYDVSDILQKMDVKDLTTDQIESQLKDRVKKLSSDQLKLVSNGETKTIDQQTGVFEFSVEVQANQKQAYYIVNESSPENISNSEDILLLTPVSEKTVNS Kraken2_NZ_CP064427.1 IMICODJL_27435 Prodigal:2.6 12504 12893 - VFG042987(gb|ACI49670) 98.1 2.0999999999999998e-67 (ACI49670) putative pilus-dedicated sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MPQSIEQERQQKRILLFDVSKIELGDPVGILTIPSISLKLPIYDGTSDKILENGVGITEGTGDITGGNGKNPLIAGHSGLYKDNLFDDLPSVKKGEKFYIKVDGEQHAYQIDRIEEVQKTNYKETLSLT Kraken2_NZ_CP064427.1 IMICODJL_27438 Prodigal:2.6 13521 14384 - VFG042988(gb|ACI49671) 96.9 8.669999999999999e-197 (pilA) PilA VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MSFELTKFGDDGTEQSKQTPLKGAKFELYKGEPGKGSKLGDLVSDDQGKLTATDLTLGKYYFVEVPSEVVVGSDKEPTADQYLLGADARNDAHNKLTFEITNDGVTSDLKASYVNYKAPVIDKTVTNGTGQEHSFQVGDAVNYQGTIHIPTDIAGGADGITVNGVKSETSPYSVFKWGDTAGQGLSYVAAKANIKVTNKDGSVVLKENTDYKIQNSENGFVIDFIVNNGQVSDTVASLHGQDLQMTYNMYVNDSAAVANPLTNSVDFVYNNNPFNQEEHHEKRKLTL Kraken2_NZ_CP064427.1 IMICODJL_27441 Prodigal:2.6 15265 15618 - VFG042989(gb|ACI49672) 100.0 1.14e-74 (ACI49672) putative housekeeping sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MPVDQINAHAKSYKEDATNVNNDMSLGQMLSIQKEAIEMGVNKQVFAQIQIPALGLALPIFKGANQYTLSLGAATYFYEDAEMGKGNYVLAGHNMEMPGVLFSDIQKLSLGEGDGLS Kraken2_NZ_CP064435.1 IMICODJL_27953 Prodigal:2.6 31716 33806 - VFG042984(gb|ACI49668) 99.0 0.0 (ACI49668) minor pilin subunit VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MNFKHSWTRRLKYVFPIMMMLGTLFGLKTANVFAEKVIVDPSNPIQNVKNNFIIPKDVPNAKTNITVNGASKVYKYHVDANKGGFTDDYVGLVEGNKNIRYPSFQKEYGETNLVLEGVTTNTKVNIDYGKIGTYNGKKVNIKLVLSNIHLYSDTLPWNLLDNNYTKTHFRDDGYKNTNGAMSKSKKRTVLWISDNLFSGIVYHSTQMNVQLVATYEDGSPVQFSGDTFISFNSLNPAGGKSTDLKGEYAHYDKMNTTDWYVRKDTVLSEFKSFYNNLNVVGGHPGGSSKLTQADNDFNNLHDKLGDPKFGQGTVSFKISEANPTFVIGSSNVQTWFTLSSATIFSVVPDQPEKTGVDKNGNNVNDKMLQVGDTIQYRIKQKVNRLGVDLLAVYDRFELIDNLPKEVNYVDAHVESGTNKKFDVSGEVTYDKTKHQVKYAAKADTLKNRMKYNGETYELVINVKVNELANQNSVAKNQGTSIINKVEKDTNIITVYFPKIPVKEVQQNGKDVNGRNDGKKGTPTAPLNAGSEVQYLVTQKWHTKGVDAASDHYKQFSIQDPIEARLTYKEGSAQVIDKSKGKDITSEGTLTYDSNSRTLKWEASADFLNNNLLDGREIQLIFTAKTPLQSEKNIDNQAVVAVDNVSNKTNVVTIGVDPNLPQVIVPKTGSTHLVTILAVSLLLLVLATFGYAVLKFN Kraken2_NZ_CP064435.1 IMICODJL_27954 Prodigal:2.6 33803 34063 - VFG042985(gb|ACI49669) 96.5 4.35e-49 (ACI49669) hypothetical hydrophobic peptide VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKLIKLLLFNFSCLTAVFLYCGLLFSKLSILPSYQLYLMRILNIPAASMPLDIMEKLIRNPLFTTINLIVIVGISLVIYKKEGMKG Kraken2_NZ_CP064435.1 IMICODJL_27955 Prodigal:2.6 34076 34837 - VFG042986(gb|ACI49673) 98.4 2.37e-158 (ACI49673) cell wall-associated LPXTG-like protein VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MRNRKWLFVCAAALFSFTAYTQLTFADRQESTDSTEQTIQTSDSSTIQSSDETVDSSTVDSSEEPKIAEDDQIVKQTIHVQKIISSEQLDNQGQKLEKQEGVNGAKFSVYDVSDILQKMDVKDLTTDQIESQLKDRVKKLSSDQLKLISNGETKTIDQQTGVFEFSVEVQANQKQAYYIVNESSPENISNSEDILLLTPVSDKNGEFLKDVWIYPKSEASQPKEEVKKIVSTGVKKNFFENCWDFVTHLFSRD Kraken2_NZ_CP064435.1 IMICODJL_27956 Prodigal:2.6 34853 35605 - VFG042987(gb|ACI49670) 99.2 8.91e-178 (ACI49670) putative pilus-dedicated sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MIIRHPKKKRIMGKWIIAFWLLSAVGVLLLMPAEASVAKYQQNQQIAAIDRTGTAAETDSSLDVAKIELGDPVGILTIPSISLKLPIYDGTSDKILENGVGITEGTGDITGGNGKNPLIAGHSGLYKDNLFDDLPSVKKGEKFYIKVDGEQHAYQIDRIEEVQKDELQRNFVTYLEPNPNEDRVTLMTCTPKGINTHRFLVYGKRVTFTKSELKDEENKKQKLSWKWLLGSTVFLSVMIIGSLFVYKKKK Kraken2_NZ_CP064435.1 IMICODJL_27957 Prodigal:2.6 35618 37594 - VFG042988(gb|ACI49671) 95.9 0.0 (pilA) PilA VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MAINRYVKKAGMIVGMLGIIAGCFQGYRAYAEDVTQKTPPERVNITVHKLMYDQSTQLNVDIDGIKNDGYTHDQYPTGVTKYNKADYGDVEFTLGNITDQVLPTEDSDLTNAKVDEIVKDVEDKGSNSEYVKNATNKITSAVDENGEITFADQPAYVNSKGNVYVVYESKSAAGLVTQKAKPMVVIAPMTDNTGSGFLKDIHLYPKNIVSKLSFELTKFGDDGTAQSKQTPLKGAKFELYKGEPGKGTKLGELVSDDQGKLTATDLTLGKYYFVEVPSEVVVGSDQEPTADQYLLGADARNDAHNKLTFEITNDGVTSDLKASYVNYKAPVIDKTVTNGTGEEHSFQIGDAVNYQGTIHIPTDIAGGTDGITVNGVKSETSPYSVFKWGDTAGKGLSYVAEKADIKVTNNDGSVVLKENTDYKIENSDSGFVIDFIVNNGQVSDTVANLHGQDLKMTYNMFVNDSAEIANPLTNSVDFVYNNNPFNQEEHHEKTKADVVTYGAKFLKVDSGLFGTGIKATPLEGAEFAAKNAEGKYYGGLTDTDKDGVKEAVWVDDVANAAILKSDKEGHFEITGLTEGDYSLEETKAPENYQKLTKEISFKVDKDSYKEENRITIKNNQKASVPMTGSNGFQSYVLISCLLLGAGAISAVVYFKKKA Kraken2_NZ_CP064435.1 IMICODJL_27958 Prodigal:2.6 37647 38318 - VFG042989(gb|ACI49672) 99.6 4.4400000000000004e-160 (ACI49672) putative housekeeping sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKKWLFGFLGVALIVVCSVFGYVSYQKHEGEVFKQNIEKKMPVDQINAHAKSYKEDATNVNNDMSLGQMLSIQKEAIEMGVNKQVFAQIQIPALGLALPIFKGANQYTLSLGAATYFYEDAEMGKGNYVLAGHNMEMPGVLFSDIQKLSLGEVMDLVSNDGVYRYKVTRKFIVPEYFKLIDGVPEENSFLSLPKKGEKPLLTLFTCVYTSQGKERYVVQGELQ Kraken2_NZ_CP067384.1 IMICODJL_28095 Prodigal:2.6 32033 32665 + VFG017870(gb|WP_011988518) 76.9 9.35e-112 (YPSIP31758_RS00990) ParA family protein VF1026 Icm/dot type IVB locus VFC0086 Effector delivery system MAWIVGFISQKGGVGKSTESRALAREATSCGIKTKLADLDLEQGTSSDWHRRRLAAGLPPAASVELFATAKQAIDSTGDAELLILDGPARASKGTLEIAKVADLVVQPTGASLDDLIPAIKVFNALVKDGIPRSRLVFSLSRVGTEAEEADARAYISEAGYETLAGCLFEKPAYRKAMNSGLAVTETRYKGLNERADELIQALIDKIGEE Kraken2_NZ_CP067384.1 IMICODJL_28096 Prodigal:2.6 32665 33066 + VFG017869(gb|WP_011988603) 64.5 1.0900000000000001e-21 (YPSIP31758_RS00985) hypothetical protein VF1026 Icm/dot type IVB locus VFC0086 Effector delivery system MADASKLKKRSRNSLGAPPGPDEVATSLNSPEIAPAAETADVAPESIPRNITVPSMSAPQGADEQSSPALKQSMSYVRRDGRSARKTNRIIAFATRVTPEFDNEIRDIAEHEGIKLVEVLENALAAYKQMKGY Kraken2_NZ_CP067388.1 IMICODJL_28187 Prodigal:2.6 5428 6144 - VFG014116(gb|NP_251832) 63.5 8.95e-36 (PA3142) hypothetical protein VF0085 LPS VFC0258 Immune modulation Two distinct forms of LPS: A-band and B-band. A-band is a homopolymer of alpha-linked D-rhamnose, whereas B-band LPS is a heteropolymer Mediates biological effects including resistance to serum killing and phagocytosis; the binding to normal CFTR (cystic fibrosis transmembrane conductance regulator) and invasion of host cells may make a contribution to virulence in the human eye; internalization by binding to normal CFTR protein expressed by airway epithelial cells followed by desquamation of bacteria-laden epithelial cells, constitutes a host defense mechanism. If this mechanism fails to function properly, abnormally high bacterial carriage would promote the establishment of chronic bacterial infection Binding interaction occurs between the first extracellular loop of CFTR (predicted to be in amino acids 108-117 of the mature protein) and the complete outer portion of the core polysaccharide of the LPS MCDATGLSQRRACRLTGLSLSTCRYEAQRPAADAHLSGHITELALERRRFGYRRIWQLLRREGLHVNHKRVYRLYHLNGLGVKRRRRRKGLATERLPLLRPEAPNLTWPMDFVMDALATGRRIKCLTCVDDFTKECLTITAAFGISGVQVTRMLDSIALFRGYPATIRTDQGAEFTCRALDQWAYEHGVELRLIQPGRPTQNGFIESFNGRFRDECLNEHWFRDIVHARKTINDWRQD Kraken2_NZ_CP072253.1 IMICODJL_30042 Prodigal:2.6 16935 18203 - VFG037903(gb|WP_001175102) 60.2 3.78e-184 (tviB) Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MNETKICVIGLGYVGLPLARLFSTKYKTIGFDMNQARVTALMAGHDATLEVSDELLQSALANGFKCTANIEEIRDYNFYVVAVPTPVDKNNNPDLTPLYGASTTVGKVISKGDIVVYESTVYPGVTEDECIPVVEKVSGLKFNEDFFAGYSPERINPGDKLHTVEKIKKVTSGSTPEIGKKVNEVYASVITAGTHLAPTMKVAEAAKVIENSQRDINIAFVNELSKIFTKMGIDTQDVLEAASTKWNFLPFKPGLVGGHCIGVDPYYLAQCAQRHGYNPEIILAGRRMNDGMGEYVANQVAKLMLKKGIQVLNSHILILGFTFKENCPDVRNTKVIDIYNALREYNVHITVYDPWANPDIVMREYGISVTNQHPLDKKFDAAIIAVAHEQFIGFDVKTLLNAQHVIFDVKAIFEKNVVDGRL Kraken2_NZ_CP072223.1 IMICODJL_30344 Prodigal:2.6 32746 34014 + VFG037903(gb|WP_001175102) 60.2 3.78e-184 (tviB) Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MNETKICVIGLGYVGLPLARLFSTKYKTIGFDMNQARVTALMAGHDATLEVSDELLQSALANGFKCTANIEEIRDYNFYVVAVPTPVDKNNNPDLTPLYGASTTVGKVISKGDIVVYESTVYPGVTEDECIPVVEKVSGLKFNEDFFAGYSPERINPGDKLHTVEKIKKVTSGSTPEIGKKVNEVYASVITAGTHLAPTMKVAEAAKVIENSQRDINIAFVNELSKIFTKMGIDTQDVLEAASTKWNFLPFKPGLVGGHCIGVDPYYLAQCAQRHGYNPEIILAGRRMNDGMGEYVANQVAKLMLKKGIQVLNSHILILGFTFKENCPDVRNTKVIDIYNALREYNVHITVYDPWANPDIVMREYGISVTNQHPLDKKFDAAIIAVAHEQFIGFDVKTLLNAQHVIFDVKAIFEKNVVDGRL Kraken2_NZ_CP072245.1 IMICODJL_30444 Prodigal:2.6 16940 18208 - VFG037903(gb|WP_001175102) 60.2 3.78e-184 (tviB) Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MNETKICVIGLGYVGLPLARLFSTKYKTIGFDMNQARVTALMAGHDATLEVSDELLQSALANGFKCTANIEEIRDYNFYVVAVPTPVDKNNNPDLTPLYGASTTVGKVISKGDIVVYESTVYPGVTEDECIPVVEKVSGLKFNEDFFAGYSPERINPGDKLHTVEKIKKVTSGSTPEIGKKVNEVYASVITAGTHLAPTMKVAEAAKVIENSQRDINIAFVNELSKIFTKMGIDTQDVLEAASTKWNFLPFKPGLVGGHCIGVDPYYLAQCAQRHGYNPEIILAGRRMNDGMGEYVANQVAKLMLKKGIQVLNSHILILGFTFKENCPDVRNTKVIDIYNALREYNVHITVYDPWANPDIVMREYGISVTNQHPLDKKFDAAIIAVAHEQFIGFDVKTLLNAQHVIFDVKAIFEKNVVDGRL Kraken2_NZ_CP051364.1 IMICODJL_30576 Prodigal:2.6 16662 17348 + VFG001445(gb|AAA92657) 73.9 3.05e-106 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MCPTDRRERTLASQSVNKYILSIQDIYKNSPVPVCVRNQSRKIIYANGAFIELFSKEDQPLSGDSYNRYGVEVFLSSLELECQSLGHGAAFCRRFNFHGEIYQIRMENISFDNNEIIVLWQINLFPDHPFFSPDTKTKNLSLSGTESFWNELSPGTLLVFSFYTLGVSHANIAKELGITIRASEDRIKPVKRKIKRNYESFDSFRISCISKGKIISLIDIIREFYCVK Kraken2_NZ_CP051364.1 IMICODJL_30621 Prodigal:2.6 54024 54581 - VFG000442(gb|NP_490501) 100.0 1.2600000000000001e-129 (rck) resistance to complement killing VF0108 Rck Resistance to complement killing VFC0258 Immune modulation Rck belongs to a family of five homologous OMP proteins characterized in Salmonella (Rck and PagC), Escherichia coli (Lom), Yersinia enterocolitica (Ail) and Enterobacter cloacae (OmpX) Rck is predicted to be an eight-stranded beta-barrel protein that resides in the outer membrane Confers serum resistance by binding human complement factor H.; Rck mediates cell invasion through a Zipper-like mechanism, as described for other bacteria such as Listeria and Yersinia. Salmonella seems to be the first bacterium found to be able to induce both Zipper-like mechanism and the Trigger mechanism mediated by its T3SS-1 apparatus. MKKIVLSSLLLSAAGLAAVPVAQADTHSVSVGYAQSRIEHFKDIRGVNLKYRYEAQTPLGLMASFSWQSGKRGESGGIPGGMSWRDDVKATYWSLMAGPAVRVNELVSLYALAGAGTGRAEVKERISMPGYNGRFTGSERRTGFAWGAGVQFNPVENVVIDLGYEGSKVGAAKLNGVNVGVGYRF Kraken2_NZ_CP051364.1 IMICODJL_30638 Prodigal:2.6 67581 68138 - VFG000442(gb|NP_490501) 100.0 1.2600000000000001e-129 (rck) resistance to complement killing VF0108 Rck Resistance to complement killing VFC0258 Immune modulation Rck belongs to a family of five homologous OMP proteins characterized in Salmonella (Rck and PagC), Escherichia coli (Lom), Yersinia enterocolitica (Ail) and Enterobacter cloacae (OmpX) Rck is predicted to be an eight-stranded beta-barrel protein that resides in the outer membrane Confers serum resistance by binding human complement factor H.; Rck mediates cell invasion through a Zipper-like mechanism, as described for other bacteria such as Listeria and Yersinia. Salmonella seems to be the first bacterium found to be able to induce both Zipper-like mechanism and the Trigger mechanism mediated by its T3SS-1 apparatus. MKKIVLSSLLLSAAGLAAVPVAQADTHSVSVGYAQSRIEHFKDIRGVNLKYRYEAQTPLGLMASFSWQSGKRGESGGIPGGMSWRDDVKATYWSLMAGPAVRVNELVSLYALAGAGTGRAEVKERISMPGYNGRFTGSERRTGFAWGAGVQFNPVENVVIDLGYEGSKVGAAKLNGVNVGVGYRF Kraken2_NZ_CP051364.1 IMICODJL_30647 Prodigal:2.6 72837 73529 - VFG000433(gb|NP_490508) 100.0 8.61e-166 (pefD) plasmid-encoded fimbriae chaperone protein PefD VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MNKMMKWGLVSLLSLAVSGQAMAAFVLNGTRFIYEEGRKNTSFEVTNQADETFGGQVWIDNTTQGSSTVYMVPAPPFFKVRPKEKQIIRIMKTDSTLPSDRESLFWLNVQEIPPKPKASEGNVLAVAVNTKVKLIYRPKALVEGRRNAEKNLQIAHRGGEAYLKNPTPYYFAVTGVKLNGQPVRLNDRVMNEIAQLAPKSEVALGKLSLNGTVTVQAVNDWGGTQDYTLK Kraken2_NZ_CP051364.1 IMICODJL_30648 Prodigal:2.6 73522 75930 - VFG000434(gb|NP_490509) 100.0 0.0 (pefC) plasmid-encoded fimbriae usher protein PefC VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MSFHHRVFKLSALSLALFSHLSFASTDSELNLDFLQGMSAIPSVLKSGSDFPAGQYYVDVIVNQENVGKARLSITPQEESANALCLSPEWLKAAGVPVRLEGYASTLNAAGQCYVLSRNPYTRVDFSYGSQSLVFSIPQSFLVGKTDPSRWDYGVPAARLKYSANASQTSGQSTSAYANADLMVNLGRWVLASNMSASRYADGSGEFTARDITLSTAISQVQGDLLLGKSQTRSALFSDFGFYGAALRSNSNMLPWEARGYAPLITGVANSTSRVTISQNGYAVYSKVVPPGPYQLDDVRSVGNGDLVVTVEDASGHKTTTVYPVTTLPTLLRPGEVEYNVAVGRKSSNYKLKKPFADGENGMFWMGSVGYGFDSTTLNAASILHGKYQAGGVSVTQALGGFGAVSAGMNLSQAKYDNGDNKRGHSVSAKYAKSFSDSSDLQLLAYRYQSKGYVEFADFYSTDRYTRYNTKSRYEMRFSQRLGNSNLNLAGWQEDYWWMKGKAIGGDVSLSTTILDGVSVFLNGSYSKRPYLDKPDYSTSLSFSIPFTLGGVRHYSSTGLSYSSSGRMGMNSGVSASPTDRLSYGLNTNLSDKGDRSLSGNLSYGFDAIQTNMMLSQGRDNTTVSGSVSGTILGTADSGLMMTKETGNTLGVARIPGVKGVRINGSAPTNSKGYTVVNLSDYSLNRVSVDMENVPDDLELQTTSFNVVPTEKAVVYREFGAEHVLRYILRVKERDGRILNGGSAQTEQGLDAGFIAGNGVLLMNMLSAPSRVSVERGDGSVCHFSVKGIVPNTGKVQEVYCE Kraken2_NZ_CP051364.1 IMICODJL_30649 Prodigal:2.6 76158 76676 - VFG000435(gb|NP_490510) 100.0 5.8499999999999975e-115 (pefA) plasmid-encoded fimbriae major subunit PefA VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MKKSIIASIIALGVLGGTAHAANEVTFLGSVSATTCDLTTSVNGAAQPNQVVQLGTVQANQPGNFVDFAMKPVDPNAQGCANLAQKTATVSWASAALDGEGFGATSGTATDAKVLVESVNSKNPGAVNANASTVDFEGAKLTTDGLQFKAKLKGGATEGDFKSVASFAVAYK Kraken2_NZ_CP051364.1 IMICODJL_30650 Prodigal:2.6 76951 77253 - VFG000436(gb|NP_490511) 100.0 1.7499999999999999e-68 (pefB) plasmid-encoded fimbriae regulatory protein PefB VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MMLNRKDADYYLGKEIMLARIRRGALIPAKVNEEHFWLLIGISSIHSEKIIQALRDYLVFGVSRKDVCERYEVNNGYFSTSLNRLSRISQAAAQMVVYYS Kraken2_NZ_CP051364.1 IMICODJL_30668 Prodigal:2.6 88856 89506 - VFG000437(gb|NP_490527) 100.0 1.38e-155 (spvD) Salmonella plasmid virulence: hydrophilic protein VF0947 TTSS-2 secreted effectors VFC0086 Effector delivery system GogB; PipB; PipB2 (Directly binds kinesin, a plus end-directed microtubule motor protein. Localizes to the phagosome; Promotes Sif extension, recuits kinesin-1 to SCV. ); SifA (GEF. Localizes to the cytosolic face of the SCV and binds to host protein-kinesin-binding protein SKIP to modulate phagosome tubulation; required for SCV membrane integrity and Sif formation; maintains perinuclear SCV positioning; redirects exocytic vesicles to SCV. ); SifB (GEF, WxxxE family. ); SopD2 (Inhibits vesicle transport from the vacuole; down-modulates the formation of tubular structures. ); SpiC/ssaB (SsaL/ssaM/spiC regulatory complex, sensing host cell signals to activate effector secretion. ); SpvB (ADP-ribosyltransferase. Causes cytoskeletal disruption and apoptosis. ); SpvC; SpvD; SseF (Localizes to the phagosome, contributes to Sif formation; recruits dynein to SCV; maintains perinuclear SCV positioning; required for formation of microtubule bundles around SCV; redirects exocytic transport vesicles to SCV. ); SseG (Same as SseF. ); SseI/srfH (Blocks the migration of host immune cells by associating with host protein IQGAP1, an important regulator of cell migration; attenuates the host's ability to clear systemic bacteria. ); SseJ (Glycerophospholipid-cholesterol acyl transferase and deacylase. SseJ and SifA interact in a protein complex with SKIP and RhoA family GTPases as a mechanism to promote phagosome tubulation. ); SseK1; SseK2; SseL (Deubiquitinase. Required for Salmonella-induced delayed cytotoxicity of macrophages. ); SspH2 (Novel E3 ubiquitin-ligase. Specifically localizes to the brush border of polorized epithelial cells. ); SteC (Serine/Threonine kinase. Required for SPI-2 dependent F-actin remodelling. ) MRVSGSASSQDIISRINSKNINNNDSNEVKRIKDALCIESKERILYPQNLSRDNLKQMARYVNNTYVHYSGNCVLLSACLHYNIHHRQDILSSKNTASPTVGLDSAIVDKIIFGHELNQSYCLNSIDEVEKEILNRYDIKRESSFIISAENYIAPIIGECRHDFNAVVICEYDKKPYVQFIDSWKTSNILPSLQEIKKHFSSSGEFYVRAYDEKHD Kraken2_NZ_CP051364.1 IMICODJL_30669 Prodigal:2.6 89767 90492 - VFG000438(gb|NP_490528) 100.0 2.2e-178 (spvC) type III secretion system effector SpvC, phosphothreonine lyase VF0947 TTSS-2 secreted effectors VFC0086 Effector delivery system GogB; PipB; PipB2 (Directly binds kinesin, a plus end-directed microtubule motor protein. Localizes to the phagosome; Promotes Sif extension, recuits kinesin-1 to SCV. ); SifA (GEF. Localizes to the cytosolic face of the SCV and binds to host protein-kinesin-binding protein SKIP to modulate phagosome tubulation; required for SCV membrane integrity and Sif formation; maintains perinuclear SCV positioning; redirects exocytic vesicles to SCV. ); SifB (GEF, WxxxE family. ); SopD2 (Inhibits vesicle transport from the vacuole; down-modulates the formation of tubular structures. ); SpiC/ssaB (SsaL/ssaM/spiC regulatory complex, sensing host cell signals to activate effector secretion. ); SpvB (ADP-ribosyltransferase. Causes cytoskeletal disruption and apoptosis. ); SpvC; SpvD; SseF (Localizes to the phagosome, contributes to Sif formation; recruits dynein to SCV; maintains perinuclear SCV positioning; required for formation of microtubule bundles around SCV; redirects exocytic transport vesicles to SCV. ); SseG (Same as SseF. ); SseI/srfH (Blocks the migration of host immune cells by associating with host protein IQGAP1, an important regulator of cell migration; attenuates the host's ability to clear systemic bacteria. ); SseJ (Glycerophospholipid-cholesterol acyl transferase and deacylase. SseJ and SifA interact in a protein complex with SKIP and RhoA family GTPases as a mechanism to promote phagosome tubulation. ); SseK1; SseK2; SseL (Deubiquitinase. Required for Salmonella-induced delayed cytotoxicity of macrophages. ); SspH2 (Novel E3 ubiquitin-ligase. Specifically localizes to the brush border of polorized epithelial cells. ); SteC (Serine/Threonine kinase. Required for SPI-2 dependent F-actin remodelling. ) MPINRPNLNLNIPPLNIVAAYDGAEIPSTNKHLKNNFNSLHNQMRKMPVSHFKEALDVPDYSGMRQSGFFAMSQGFQLNNHGYDVFIHARRESPQSQGKFAGDKFHISVLRDMVPQAFQALSGLLFSEDSPVDKWKVTDMEKVVQQARVSLGAQFTLYIKPDQENSQYSASFLHKTRQFIECLESRLSENGVISGQCPESDVHPENWKYLSYRNELRSGRDGGEMQRQALREEPFYRLMTE Kraken2_NZ_CP051364.1 IMICODJL_30670 Prodigal:2.6 90773 92548 - VFG000439(gb|NP_490529) 100.0 0.0 (spvB) type III secretion system effector SpvB, ADP-ribosylation activity VF0107 SpvB VFC0235 Exotoxin PDB accession: 2GWL SpvB-mediated actin depolymerization is associated with an accumulation of cells in the G2/M phase, eventually resulting in apoptotic cell death An ADP-ribosylating toxin that modifies actin directly and totally disrupt the cytoskeleton of the cell MLILNGFSSATLALITPPFLPKGGKALSQSGPDGLASITLPLPISAERGFAPALALHYSSGGGNGPFGVGWSCATMSIARRTSHGVPQYNDSDEFLGPDGEVLVQTLSTGDAPNPVTCFAYGDVSFPQSYTVTRYQPRTESSFYRLEYWVGNSNGDDFWLLHDSNGILHLLGKTAAARLSDPQAASHTAQWLVEESVTPAGEHIYYSYLAENGDNVDLNGNEAGRDRSAMRYLSKVQYGNATPAADLYLWTSATPAVQWLFTLVFDYGERGVDPQVPPAFTAQNSWLARQDPFSLYNYGFEIRLHRLCRQVLMFHHFPDELGEADTLVSRLLLEYDENPILTQLCAARTLAYEGDGYRRAPVNNMMPPPPPPPMMGGNSSRPKSKWAIVEESKQIQALRYYSAQGYSVINKYLRGDDYPETQAKETLLSRDYLSTNEPSDEEFKNAMSVYINDIAEGLSSLPETDHRVVYRGLKLDKPALSDVLKEYTTIGNIIIDKAFMSTSPDKAWINDTILNIYLEKGHKGRILGDVAHFKGEAEMLFPPNTKLKIESIVNCGSQDFASQLSKLRLSDDATADTNRIKRIINMRVLNS Kraken2_NZ_CP051364.1 IMICODJL_30680 Prodigal:2.6 100110 100850 - VFG002301(gb|NP_490536) 100.0 2.74e-170 (mig-5) putative carbonic anhydrase VF0396 Mig-5 Macrophage-inducible gene-5 VFC0325 Antimicrobial activity/Competitive advantage Mig-5 was found to be expressed by Salmonella when ingested by macrophages. mig-5 codes for the carbonic anhydrase which catalyses the hydratation of carbon dioxide and formation of HCO3-. The biological meaning of this reaction in intracellularilly residing of Salmonella is, however, not known. MEQNQPAQPSRRAILKQTLAVSALSVTGLAALSVPTISFAASLSKEERDGMTPDAVIEHFKQGNLRFRENRPAKHDYLAQKRNSIAGQYPAAVILSCIDSRAPAEIVLDAGIGETFNSRVAGNISNRDMLGSMEFACAVAGAKVVLVIGHTRCGAVRCAIDNAELGNLTGLLDEIKPAIAKTEYSGERKGSNYDFVDAVARKNVELTIENIRKNSPVLKQLEDEKKIKIVGSMYHLTGGKVEFFEV Kraken2_NZ_CP051311.1 IMICODJL_30812 Prodigal:2.6 88604 89989 - VFG034652(gb|WP_000074204) 72.5 3.61e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPAAPVPQQFSLSHNSLTPAVNGYQDTGWRNFFVDPQVTRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDARLELSYELDFFGKLKNMSDADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYQQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_CP051312.1 IMICODJL_30999 Prodigal:2.6 40860 41420 - VFG042890(gb|WP_000334696) 64.3 3.1199999999999996e-69 (STY_RS21730) lytic transglycosylase domain-containing protein VF0966 Type IV pili VFC0001 Adherence MSGGTVPLRLISLILLFSLIPPARASYVAPKQIWTNKWDNCFAAAGARYQIEPLLLKAISAGESSLRPGAININKDKKTGKASSTDYGLMQINSTHIPKLINMGVIKKSEDLITKPCLNIHIGSWILARHFQICGVSWNCLGSYNAGFRKDRHETREQYANKIWRIYRDMKGICLPGQGGRQCRQS Kraken2_NZ_CP051312.1 IMICODJL_31032 Prodigal:2.6 67039 68919 + VFG043980(gb|WP_001283355) 95.8 0.0 (HS453_RS00480) colicin-like pore-forming protein VF1184 Colicin Ib VFC0235 Exotoxin MSDPVRITNPGAESLGYDSDGHEIMAVDIYVNPPRVDVFHGTPPAWSSFGNKTIWGGNEWVDDSPTRSDIEKRDKEITAYKNTLSAQQKENENKRTEAGKRLSAAIAAREKDENTLKTLRAGNADAADITRQEFRLLQAELREYGFRTEIAGYDALRLHTESRMLFADADSLRISPREARSLIEQAEKRQKDAQNADKKAADMLAEYERRKGILDTRLSELEKNGGAALAVLDAQQARLLGQQTRNDRAISEARNKLSSVTESLKTARNALTRAEQQLTQQKNTPDGKTIVSPEKFPGRSSTNHSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLTHSGLDYKRNILNDRNPVVTEDVEGDKKIYNAEVAEWDKLRQRLLDARNKITSAESAINSARNNVSARTNEQKHANDALNALLKEKENIRSQLADINQKIAEEKRKRDEINMVKDAIKLTSDFYRTIYDEFGKQASELAKELASVSQGKQIKSVDDALNAFDKFRNNLNKKYNIQDRMAISKALEAINQVHMAENFKLFSKAFGFTGKVIDRYDVAVELQKAVKTDNWRPFFVKLESLAAGRAASAVTAWAFSVMLGTPVGILGFAIIMAAVSALVNDKFIEQVNKLIGI Kraken2_NZ_CP051316.1 IMICODJL_31234 Prodigal:2.6 120513 122150 + VFG045692(gb|WP_197532029) 75.6 8.29e-275 (htpB) Hsp60, 60K heat shock protein HtpB VF0159 Hsp60 VFC0001 Adherence Mediate a complement-independent attachment to mammalian and amoebal host cells Specific receptors have not been identified MAAKDIRFGEDARARMVRGVNVLANAVKATLGPKGRNVVLEKSFGAPTITKDGVSVAKEIELADKFENMGAQMVKEVASKTSDNAGDGTTTATVLAQALIREGMKAVAAGMNPMDLKRGIDKAVTSAVEELKKISKPCSTSKEIAQVGSISANSDTDIGELIAKAMDKVGKEGVITVEEGSGLENELDVVEGMQFDRGYLSPYFINNPQSMQAELEDPFILLHDKKISNVRDLLPILEGVAKAGKPLLIVAEDVEGEALATLVVNTIRGIVKVCAVKAPGFGDRRKAMLEDMAILTGGTVISEEVGLSLEKATINDLGRAKKVQVSKENTTIIDGAGDTADIEARIKQIKAQIEETTSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALIRAKAAIAELKGANEDQNHGIAIALRAMEAPLREIVTNAGDEPSVVLNRVAEGTGAFGYNAANGEFGDMIEFGILDPTKVTRSALQNAASIAGLMITTEAMVAEAPKKEEPAAPGGGMGGMGGMDF Kraken2_NZ_CP051347.1 IMICODJL_31363 Prodigal:2.6 67839 70037 - VFG012518(gb|WP_000973517) 100.0 0.0 (iutA) ferric aerobactin receptor precusor IutA VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNIDHIEVISGATSLYGGGSTGGLINIVTKKGQPETMMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTERHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAAFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIAAGKATSADAIPGGSVDYDNFLFNAGLLMHITERQQAWLNFSQGVELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTADLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF Kraken2_NZ_CP051347.1 IMICODJL_31364 Prodigal:2.6 70122 71399 - VFG033958(gb|WP_000750130) 100.0 0.0 (iucD) L-lysine 6-monooxygenase IucD VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MKKSVDFIGVGTGPFNLSIAALSHQIEELDCLFFDEHPHFSWHPGMLVPDCHMQTVFLKDLVSAVAPTNPYSFVNYLVKHKKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVENIDFDKKRRLFLVQTSQGEYFARNICLGTGKQPYLPPCVKHMTQSCFHASEMNLRRPDLSGKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISGFSGLEEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLESSGPGWKLLMEHHLDQGRESLESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDDFTLEWSGPKENNIFVVNASMQTHGIAEPQLSLMAWRSARILNRVMGRDLFDLSMPPALIQWRSGT Kraken2_NZ_CP051347.1 IMICODJL_31365 Prodigal:2.6 71396 73138 - VFG012522(gb|WP_001015721) 100.0 0.0 (iucC) aerobactin siderophore biosynthesis protein IucC VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MNHKDWDLVNRRLVAKMLSELEYEQVFHAESQGDDRYCINLPGAQWRFIAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKQVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLINLNADRLQCLLSGHPKFVFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMIWRCDNEMDIHQLLTAAMDPQEFARFSQVWQENGLDHNWLPLPVHPWQWQQKIATDFIADFAEGRMVSLGEFGDQWLAQQSLRTLTNASRRGGLDIKLPLTIYNTSCYRGIPGRYIAAGPLASRWLQQVFATDATLVQSGAVILGEPAAGYVSHEGYAALARAPYRYQEMLGVIWRENPCRWLKPDESPVLMATLMECDENNQPLAGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKEGVPQRVLLKDFQGDMRLVKEEFPEMDSLPQEVRDVTSRLSADYLIHDLQTGHFVTVLRFISPLMVRLGVPERRFYQLLAAVLSDYMKKHPQMSERFALFSLFRPQIIRVVLNPVKLTWPDLDGGSRMLPNYLEDLQNPLWLVTQEYES Kraken2_NZ_CP051347.1 IMICODJL_31366 Prodigal:2.6 73138 74085 - VFG012524(gb|WP_000011907) 100.0 1.8400000000000002e-248 (iucB) aerobactin siderophore biosynthesis protein IucB VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MSGANIVHSGYGLRCEKLDKPLNLGWGLDNSAVLHWPGELPTGWLCDALDQIFIAAPQLSAVVLPWSEWCEEPQALTLFGQVQSDIIHRSAFWQLPLWLSSPANRASGEMVFDAEREIYFPQRPPRPQGEVYRRYDPRIRRMLSFRIADPVSDAERFTRWMNDPRVEYFWEQSGSLEVQIAYLERQLTSKHAFPLIGCFDDRPFSYFEIYWAAEDRIGRHYSWQPFDRGLHLLVGEQQWRGAHYVQSWLRGVTHYLLLNEPRTQRTVLEPRIDNQRLFRHLEPAGYRTIKEFDFPHKRSRMVMADRHHFFTEVGL Kraken2_NZ_CP051347.1 IMICODJL_31367 Prodigal:2.6 74086 75810 - VFG012526(gb|WP_000602863) 100.0 0.0 (iucA) aerobactin siderophore biosynthesis protein IucD VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MILPSEKSATDVAAQCFLNALIRETKDWQLAEYPPDELIIPLDEQKSLHFRVAYFSPTQHHRFAFPAHLVTASGSYPVDFTTLSRLIIDKLRHQLFLPVPLCETFHQRVLESYAHTQQTIDARHDWAILREKALNFGEAEQALLTGHAFHPAPKSHEPFNRQEAERYLPDMAPHFPLRWFSVDKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLHPWQGEYLLQQVWCQALFAKGLIRDLGEAGTSWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVERGMRLARLAQTDGWQMLQARFPTFRVMQEDGWAGLRDLNGNIMQESLFSLRENLLLEQPQSQTNVLVSLTQAAPDGGDSLLVSAVKRLSDRLGITVQQAAHAWVDAYCQQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGFIYRDCQGSAFMPHATEWLDTIDEAQAENIFTREQLLRYFPYYLLVNSTFAVTAALGAAGLDSEANLMARVRTLLAEVRDQVTHKTCLNYVLESPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLQAQEV Kraken2_NZ_CP051347.1 IMICODJL_31372 Prodigal:2.6 79142 79999 - VFG012590(gb|WP_000968139) 100.0 1.78e-190 (sitD) iron/manganese ABC transporter permease subunit SitD VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MMALLLEPLQFTFMSHALLISLVVSIPCALLSVFLVLKSWALMGDAMSHAVFPGIVLAWILGLPLATGAFVAGVFCAVATGYLKDNSRIKQDTVMGIVFSGMFAAGLILYIAVKPDVHLDHILFGDMLGITIGDIIQTVIIAGLVTLVISVKWRDFLLFSFDYQQAQASGLHTRWLHYGLLCMVSLTIVATLKAVGIILSISLLIAPGAIAVLLTQRFHIALLLATGISILVSMTGVWLSFFIDSAPAPTIVVLFAVMFIMTFTVTSINARTKENAEPRDLLSSD Kraken2_NZ_CP051347.1 IMICODJL_31373 Prodigal:2.6 79996 80853 - VFG012585(gb|WP_001101723) 99.6 4.26e-198 (sitC) iron/manganese ABC transporter permease subunit SitC VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MNALLEPFSYEYMLNAMWVSAMVGGLCAFLSCYLMLKGWSLIGDALSHSIVPGVAGAYMLGLPFSLGAFFSGGLAAGSMLFLNQLTRLKEDAIIGLIFSSFFGLGLFMVSLNPTSVNIQTIVLGNILAIDPADILQLTIIGILSIIVLFFKWKDLMVTFFDENHARAIGLHPGRLKILFFTLLSVSTVAALQTVGAFLVICLVVTPGATAWLLTDRFPRLLMIAVTIGSVTSFLGAWVSYFLDGATGGIIVVAQTLLFLLAFVFAPTHGLLANRRRAHKALEDRS Kraken2_NZ_CP051347.1 IMICODJL_31374 Prodigal:2.6 80850 81674 - VFG034214(gb|WP_000983710) 100.0 3.3500000000000003e-192 (sitB) iron/manganese ABC transporter ATP-binding protein SitB VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MQSAGIVVNDVTVTWRNGHTALRDASFTVPGGSIAALVGVNGSGKSTLFKAIMGFVRLTSGKISVLGIPTRQALQKNLVAYVPQSEEVDWSFPVLVEDVVMMGRYGHMGMLRIAKKRDRQIVTDALERVDMVDFRHRQIGELSGGQKKRVFLARAIAQQGDVILLDEPFTGVDVKTEAKIISLLRELRAEGKTMLVSTHNLGSVTTFCDYTVMVKGTVLASGPTDTTFTAENLELAFSGVLRHVTLNGSEESIITDDERPFVAHRPSAVQREER Kraken2_NZ_CP051347.1 IMICODJL_31375 Prodigal:2.6 81677 82591 - VFG012575(gb|WP_000949004) 100.0 4.37e-221 (sitA) iron/manganese ABC transporter substrate-binding protein SitA VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MLSIKKVTMLLGCLVLTCSIAFQASAAEKFKVITTFTIIADMAKNVAGDAAEVSSITKPGAEIHEYQPTPGDIKRAQGAQLILANGMNLELWFQRFYQHLNGVPEVIVSSGVTPVGITEGPYEGKPNPHAWMSPDNALIYVDNIRDAFIKYDPANAQTYQRNADTYKAKITQTLAPLRKQIAELPENQRWMVTSEGAFSYLARDLGLKELYLWPINADQQGTPQQVRKVVDIVKKNHIPAVFSESTISDKPARQVARETGAHYGGVLYVDSLSTENGPVPTYIDLLKVTTSTLVQGIKAGKREK Kraken2_NZ_CP051347.1 IMICODJL_31408 Prodigal:2.6 112214 113329 + VFG012515(gb|WP_001318220) 100.0 1.3600000000000001e-276 (iroB) glucosyltransferase IroB VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MRILFVGPPLYGLLYPVLSLAQAFRVNGHEVLIASGGQFAQKAAEAGLVVFDAAPGLDSEAGYRHHEAQRKKSNIGTQMGNFSFFSEEMADHLVEFAGHWRPDLIIYPPLGVIGPLIAAKYDIPVVMQTVGFGHTPWHIKGVTRSLTDAYRRHNVGATPRDMAWIDVTPPSMSILENDGEPIIPMQYVPYNGGAVWEPWWERRPERKRLLVSLGTVKPMVDGLDLIAWVMDSASEVDAEIILHISANARSDLRSLPSNVRLVDWIPMGVFLNGADGFIHHGGAGNTLTALHAGIPQIVFGQGADRPVNARVVAERGCGIIPGDVGLSSNMINAFLNNRSLRKASEEVAAEMAAQPCPGEVAKSLITMVQKG Kraken2_NZ_CP051347.1 IMICODJL_31409 Prodigal:2.6 113469 117128 + VFG012511(gb|WP_001442133) 100.0 0.0 (iroC) ATP binding cassette transporter VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MPANHTPTPAQSWIVRLARVCWERKKLSVIVVVASVSTILLAALTPLLTRQAVNDALAGNPARLPWLACGLLLIAFFDFIGNYVRRGYAGMLSLWVQHTLRGRVFDSIQKLDGAGQDALRTGQVISRTNSDLQQVHTLLQMCPVPLAVFTYYIAGIAVMLWMSPAMTLIVVCVLVCLAITALRARRRVFAQTGLASDQLANLTEHIREVLAQISVVKSCVAEMRETHWLDRQSRQIVRVRIGAVISQAMPGATMLALPVLGQIVLLCYGGWSVMHGRIDLGTFVAFASFLAMLTGPTRVLASFLVIAQRTQASVERVFALIDTRSQMEDGTESINSQVVGLELENMSFDYHHGDRHILSNISFSLRAGETVAVVGASGSGKSTLLMLLARFYDPCSGKIWLNTSEGRQNLRDIRLEALRRRVGIVFEDAFLFAGTVAENIAYGHPQATADDIRRAAAAAGASDFINALPKGFDSLLTERGTNLSGGQRQRIALARALITAPDVLILDDTTSAVDAVTEAEINTALGRYADEGHMLLVIARRRSTLQLASRVVVLDKGRMVDTGTPAELEARCPAFRALMTGDSDFLATSHNSHNELWPAEPATQDDVTDTGDKGFVARMTRVPENAVQQALAGKGRKVTSLLKPVAWMFVIAALLIALDSAAGVGVLILLQHGIDSGVAAGDMSIIGLCALLALCLVIVGWCSYSLQTVFAARAAESVQHSVRLRSFGHMLRLGLPWHEKHADSRLTRMTVDVDSLARFLQNGLAGAATSLVTMFAIAATMFWLDPFLALTALSAVPVAALATMIYRRLSTPAYAQARLEIGKVNSTLQEKVSGLRVVQSHGQQELEGARLRALSERFRATRVRAQKYLAVYFPFLTFCTEASYAAVLLVGASQVAAGEMTAGVLAAFFLLLGQFYGPVQQLSGIVDAWQQATASGKHIDELLATEGTENLGSSSVLPVTGALHLDEVTFSYPDSHEPALNKLTLTIPEGMVVAVVGRSGAGKSTLIKLIAGLYFPTHGNIRIGVQMLDDASLTEYRRQIGLVDQDVALFSSDIAENIRYSRPSATNEDVEIASQRAGLYEMVCNLPQGFRTPVNNGGADLPAGQRQLIALARAQLANAHILLLDEATSCLDRTSEERLMSSLTDVVHAGKHSALIVAHRLTTAQRCDLIAVIDKGLLAEYGTHEQLLSAGGLYTRLWHDSVSSTALHRQHNMKEETPG Kraken2_NZ_CP051347.1 IMICODJL_31410 Prodigal:2.6 117232 118461 + VFG012507(gb|WP_000933672) 100.0 1.1e-308 (iroD) esterase VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MLNMQQHLSAIASLRNQLAAGHIANLTDFWREAESLNVPLVTPVEGAEDEREVTFLWRARHPLQGVYLRLNRVTDKEHVEKGMMSALPETDIWTLTLRLPASYCGSYSLLEIPPGTTAETIALSGGRFATLAGKADPLNKMPEINVRGNAKESVLTLDKAPALSEWNGGFHTGQLLTSMRIIAGKSRQVRLYIPDVDISQPLGLVVLPDGETWFDHLGVCAAIDAAINNGRIVPVAVLGIDNINEHERTEILGGRSKLIKDIAGHLLPMIRAEQPQRQWADRSRTVLAGQSLGGISALMGARYAPETFGLVLSHSPSMWWTPERTSRPGLFSETDTSWVSEHLLSAPPQGVRISLCVGSLEGSTVPHVQQLHQRLITAGVESHCAIYTGGHDYAWWRGALIDGIGLLQG Kraken2_NZ_CP051347.1 IMICODJL_31411 Prodigal:2.6 118546 119502 + VFG012503(gb|WP_000271277) 100.0 3.4099999999999996e-241 (iroE) esterase VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MYAREYRSTRPHKAIFFHLSCLTLICSAQVYAKPDMRPLGPNIADKGSVFYHFSVTSFDSVDGTRHYRVWTAVPNTTAPASGYPILYMLDGNAVMDRLDDELLKQLSEKTPPVIVAVGYQTNLPFDLNSRAYDYTPAAESRKTDLHSGRFSRKSGGSNNFRQLLETRIAPKVEQGLNIDRQRRGLWGHSYGGLFVLDSWLSSSYFRSYYSASPSLGRGYDALLSRVTAVEPLQFCAKHLAIMEGSATQGDNRETHAVGVLSKIHTTLTILKDKGVNAVFWDFPNLGHGPMFNASFRQALLDISGENANYTAGCHELSH Kraken2_NZ_CP051347.1 IMICODJL_31412 Prodigal:2.6 119547 121724 - VFG012499(gb|WP_001222186) 100.0 0.0 (iroN) salmochelin receptor IroN VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MRINKILWSLTVLLVGLNSQVSVAKSSDDDNDETLVVEATAEQVLKQQPGVSVITSEDIKKTPPVNDLSDIIRKMPGVNLTGNSASGTRGNNRQIDIRGMGPENTLILIDGVPVTSRNSVRYSWRGERDTRGDTNWVPPEQVERIEVIRGPAAARYGSGAAGGVVNIITKRPTNDWHGSLSLYTNQPESSDEGATRRANFSLSGPLAGNALTTRLYGNLNKTDADSWDINSPVGTKNAAGHEGVRNKDINGVVSWKLNPQQILDFEAGYSRQGNIYAGDTQNSSSSAVTESLAKSGKETNRLYRQNYGITHNGIWDWGQSRFGVYYEKTNNTRMNEGLSGGGEGRILAGEKFTTNRLSSWRTSGELNIPLNVMVDQTLTVGAEWNRDKLDDPSSTSLTVNDSDISGISGSAADRSSKNHSQISALYIEDNIEPVPGTNIIPGLRFDYLSDSGGNFSPSLNLSQELGDYFKVKAGVARTFKAPNLYQSSEGYLLYSKGNGCPKDITSGGCYLIGNKDLDPEISVNKEIGLEFTWEDYHASVTYFRNDYQNKIVAGDNVIGQTASGAYILKWQNGGKALVDGIEASMSFPLVKDRLNWNTNATWMITSEQKDTGNPLSVIPKYTINNSLNWTITQAFSASVNWTLYGRQKPRTHAETRSEDTGGLSGKELGAYSLVGTNFNYDINKNLRLNVGVSNILNKQIFRSSEGANTYNEPGRAYYAGVTASF Kraken2_NZ_CP051347.1 IMICODJL_31431 Prodigal:2.6 136041 137921 - VFG044067(gb|WP_001283335) 100.0 0.0 (ECS88_RS00560) colicin-like pore-forming protein VF1183 Colicin Ia VFC0235 Exotoxin MSDPVRITNPGAESLGYDSDGHEIMAVDIYVNPPRVDVFHGTPPAWSSFGNKTIWGGNEWVDDSPTRSDIEKRDKEITAYKMTLSAQQKENENKRTEAAKRLSAAIAAREKDENTLKTLRAGNADAADITRQEFRLLQAELREYGFRTEIAGYDALRLHTESRMLFADADSLRISPREARSLIEQAEKRQKDAQNADKKAADMLAEYERRKGILDTRLSELEKNGGAALAVLDAQQARLLGQQTRNDRAISEARNKLSSVTESLNTARNALTRAEQQLTQQKNTLDGKTIVSPEKFPGRSSTNHSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLTHSGLDYKRNILNDRNPVVTEDVEGDKKIYNAEVAEWDKLRQRLLDARNKITSAESAVNSARNNLSARTNEQKHANDALNALLKEKENIRNQLAGINQKIAEEKRKQDELKATKDAINFTTEFLKSVSEKYGAKAEQLAREMAGQAKGKKIRNVEEALKTYEKYRADINKKINAKDRAAIAAALESVKLSDISSNLNRFSRGLGYAGKFTSLADWITEFGKGVRTENWRPLFVKTEAIIAGNAATALVALVFSILTGSALGIIGYGLLMAVTGALIDESLVEKANKFWGI Kraken2_NZ_CP051359.1 IMICODJL_31537 Prodigal:2.6 44002 45387 - VFG034652(gb|WP_000074204) 72.5 3.61e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPAAPVPQQFSLSHNSLTPAVNGYQDTGWRNFFVDPQVTRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDARLELSYELDFFGKLKNMSDADRQNYFASEEARRAVHILLVSNVSQSYFSQQLAYEQLRIARETLKNYQQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE Kraken2_NZ_CP051361.1 IMICODJL_32033 Prodigal:2.6 72578 73306 - VFG020668(gb|WP_000161707) 99.2 7.03e-166 (sopE) SPI-1 type III secretion system guanine nucleotide exchange factor SopE VF0949 TTSS-1 secreted effectors VFC0086 Effector delivery system AvrA (Acetyltransferase; deubiquitinase; activated by host factor inositol hexakisphosphate IP6. Inhibits inflammation, represses apoptosis and epithelial innate immunity. ); SipA/sspA (Actin-binding protein. Increases internalization efficiency; enhances actin assembly; potentiates SipC activity; triggers PMN transmigration; maintains perinuclear SCV positioning; disrupts tight junctions. ); SipB/sspB (SPI-1 effector delivery; apoptosis of phagocytes. ); SipC/sspC (Actin-binding protein, Actin nucleation and bundling. SPI-1 effector delivery; induces membrane ruffling. ); SopA (E3 ubiquitin ligase, HECT-like. Disrupts SCV integrity, induces PMN transmigration. ); SopB/sigD (Phosphoinositide phosphatase, activates RhoG and Cdc42 by stimulating endogenous exchange factors for these GTPases, SopE, SopE2 and SopB stimulate Rho-family GTPases leading to activation of MAP kinase and NF-kappaB signaling pathway in a redundant fashion. Promotes membrane fission amd macropinosome formation; manipulates membrane surface charge and trafficking of SCV; promotes epthelial cell survival; triggers nitric oxide production in macrophages; promotes fluid secretion; disrupts tight juntions. ); SopD (GTPase-activating protein activity. Functions to both activate and inhibit the inflammatory response by targeting the Rab8 GTPase, which is a negative regulator of inflammation. ); SopE2 (GEF. Induces membrane ruffling and proinflammatory responses; increases macrophage iNos expression; disrupts tight junctions. ); SptP (N-terminal domain GAP activity, C-terminal tyrosine phosphatase (PTPase) domain. Deactivating the Rho GTPases Rac and Cdc42 and reversing the cytoskeletal rearrangements induced SopE/E2/SopB effectors to effect uptake; downregulates proinflammatory response; promotes bacterial intracellular replication. ); SteA (Contains a cryptic Golgi-targeting domain and may have a role in enabling Salmonella to hijack exocytic-derived membrane cargo to the SCV and tubules. ); SteB MTKITLSPQNFRIQKQETTLLKEKSTEKNSLAKSILAVKNHFIELRSKLSERFISHKNTESSATHFHRGSASEGRAVLTNKVVKDFMLQTLNDIDIRGSASKDPAYASQTREAILSAVYSKNKDQCCNLLISKGINIAPFLQEIGEAAKNAGLPGTTKNDVFTPSGAGANPFITPLISSANSKYPRMFINQHQQASFKIYAEKIIMTEVAPLFNECAMPTPQQFQLILENIANKYIQTLPEH Kraken2_NZ_CP051377.1 IMICODJL_32076 Prodigal:2.6 13980 14666 + VFG001445(gb|AAA92657) 73.9 3.05e-106 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MCPTDRRERTLASQSVNKYILSIQDIYKNSPVPVCVRNQSRKIIYANGAFIELFSKEDQPLSGDSYNRYGVEVFLSSLELECQSLGHGAAFCRRFNFHGEIYQIRMENISFDNNEIIVLWQINLFPDHPFFSPDTKTKNLSLSGTESFWNELSPGTLLVFSFYTLGVSHANIAKELGITIRASEDRIKPVKRKIKRNYESFDSFRISCISKGKIISLIDIIREFYCVK Kraken2_NZ_CP051377.1 IMICODJL_32121 Prodigal:2.6 51342 51899 - VFG000442(gb|NP_490501) 100.0 1.2600000000000001e-129 (rck) resistance to complement killing VF0108 Rck Resistance to complement killing VFC0258 Immune modulation Rck belongs to a family of five homologous OMP proteins characterized in Salmonella (Rck and PagC), Escherichia coli (Lom), Yersinia enterocolitica (Ail) and Enterobacter cloacae (OmpX) Rck is predicted to be an eight-stranded beta-barrel protein that resides in the outer membrane Confers serum resistance by binding human complement factor H.; Rck mediates cell invasion through a Zipper-like mechanism, as described for other bacteria such as Listeria and Yersinia. Salmonella seems to be the first bacterium found to be able to induce both Zipper-like mechanism and the Trigger mechanism mediated by its T3SS-1 apparatus. MKKIVLSSLLLSAAGLAAVPVAQADTHSVSVGYAQSRIEHFKDIRGVNLKYRYEAQTPLGLMASFSWQSGKRGESGGIPGGMSWRDDVKATYWSLMAGPAVRVNELVSLYALAGAGTGRAEVKERISMPGYNGRFTGSERRTGFAWGAGVQFNPVENVVIDLGYEGSKVGAAKLNGVNVGVGYRF Kraken2_NZ_CP051377.1 IMICODJL_32130 Prodigal:2.6 56598 57290 - VFG000433(gb|NP_490508) 100.0 8.61e-166 (pefD) plasmid-encoded fimbriae chaperone protein PefD VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MNKMMKWGLVSLLSLAVSGQAMAAFVLNGTRFIYEEGRKNTSFEVTNQADETFGGQVWIDNTTQGSSTVYMVPAPPFFKVRPKEKQIIRIMKTDSTLPSDRESLFWLNVQEIPPKPKASEGNVLAVAVNTKVKLIYRPKALVEGRRNAEKNLQIAHRGGEAYLKNPTPYYFAVTGVKLNGQPVRLNDRVMNEIAQLAPKSEVALGKLSLNGTVTVQAVNDWGGTQDYTLK Kraken2_NZ_CP051377.1 IMICODJL_32131 Prodigal:2.6 57283 59691 - VFG000434(gb|NP_490509) 100.0 0.0 (pefC) plasmid-encoded fimbriae usher protein PefC VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MSFHHRVFKLSALSLALFSHLSFASTDSELNLDFLQGMSAIPSVLKSGSDFPAGQYYVDVIVNQENVGKARLSITPQEESANALCLSPEWLKAAGVPVRLEGYASTLNAAGQCYVLSRNPYTRVDFSYGSQSLVFSIPQSFLVGKTDPSRWDYGVPAARLKYSANASQTSGQSTSAYANADLMVNLGRWVLASNMSASRYADGSGEFTARDITLSTAISQVQGDLLLGKSQTRSALFSDFGFYGAALRSNSNMLPWEARGYAPLITGVANSTSRVTISQNGYAVYSKVVPPGPYQLDDVRSVGNGDLVVTVEDASGHKTTTVYPVTTLPTLLRPGEVEYNVAVGRKSSNYKLKKPFADGENGMFWMGSVGYGFDSTTLNAASILHGKYQAGGVSVTQALGGFGAVSAGMNLSQAKYDNGDNKRGHSVSAKYAKSFSDSSDLQLLAYRYQSKGYVEFADFYSTDRYTRYNTKSRYEMRFSQRLGNSNLNLAGWQEDYWWMKGKAIGGDVSLSTTILDGVSVFLNGSYSKRPYLDKPDYSTSLSFSIPFTLGGVRHYSSTGLSYSSSGRMGMNSGVSASPTDRLSYGLNTNLSDKGDRSLSGNLSYGFDAIQTNMMLSQGRDNTTVSGSVSGTILGTADSGLMMTKETGNTLGVARIPGVKGVRINGSAPTNSKGYTVVNLSDYSLNRVSVDMENVPDDLELQTTSFNVVPTEKAVVYREFGAEHVLRYILRVKERDGRILNGGSAQTEQGLDAGFIAGNGVLLMNMLSAPSRVSVERGDGSVCHFSVKGIVPNTGKVQEVYCE Kraken2_NZ_CP051377.1 IMICODJL_32132 Prodigal:2.6 59919 60437 - VFG000435(gb|NP_490510) 100.0 5.8499999999999975e-115 (pefA) plasmid-encoded fimbriae major subunit PefA VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MKKSIIASIIALGVLGGTAHAANEVTFLGSVSATTCDLTTSVNGAAQPNQVVQLGTVQANQPGNFVDFAMKPVDPNAQGCANLAQKTATVSWASAALDGEGFGATSGTATDAKVLVESVNSKNPGAVNANASTVDFEGAKLTTDGLQFKAKLKGGATEGDFKSVASFAVAYK Kraken2_NZ_CP051377.1 IMICODJL_32133 Prodigal:2.6 60712 61014 - VFG000436(gb|NP_490511) 100.0 1.7499999999999999e-68 (pefB) plasmid-encoded fimbriae regulatory protein PefB VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MMLNRKDADYYLGKEIMLARIRRGALIPAKVNEEHFWLLIGISSIHSEKIIQALRDYLVFGVSRKDVCERYEVNNGYFSTSLNRLSRISQAAAQMVVYYS Kraken2_NZ_CP051377.1 IMICODJL_32151 Prodigal:2.6 72617 73267 - VFG000437(gb|NP_490527) 100.0 1.38e-155 (spvD) Salmonella plasmid virulence: hydrophilic protein VF0947 TTSS-2 secreted effectors VFC0086 Effector delivery system GogB; PipB; PipB2 (Directly binds kinesin, a plus end-directed microtubule motor protein. Localizes to the phagosome; Promotes Sif extension, recuits kinesin-1 to SCV. ); SifA (GEF. Localizes to the cytosolic face of the SCV and binds to host protein-kinesin-binding protein SKIP to modulate phagosome tubulation; required for SCV membrane integrity and Sif formation; maintains perinuclear SCV positioning; redirects exocytic vesicles to SCV. ); SifB (GEF, WxxxE family. ); SopD2 (Inhibits vesicle transport from the vacuole; down-modulates the formation of tubular structures. ); SpiC/ssaB (SsaL/ssaM/spiC regulatory complex, sensing host cell signals to activate effector secretion. ); SpvB (ADP-ribosyltransferase. Causes cytoskeletal disruption and apoptosis. ); SpvC; SpvD; SseF (Localizes to the phagosome, contributes to Sif formation; recruits dynein to SCV; maintains perinuclear SCV positioning; required for formation of microtubule bundles around SCV; redirects exocytic transport vesicles to SCV. ); SseG (Same as SseF. ); SseI/srfH (Blocks the migration of host immune cells by associating with host protein IQGAP1, an important regulator of cell migration; attenuates the host's ability to clear systemic bacteria. ); SseJ (Glycerophospholipid-cholesterol acyl transferase and deacylase. SseJ and SifA interact in a protein complex with SKIP and RhoA family GTPases as a mechanism to promote phagosome tubulation. ); SseK1; SseK2; SseL (Deubiquitinase. Required for Salmonella-induced delayed cytotoxicity of macrophages. ); SspH2 (Novel E3 ubiquitin-ligase. Specifically localizes to the brush border of polorized epithelial cells. ); SteC (Serine/Threonine kinase. Required for SPI-2 dependent F-actin remodelling. ) MRVSGSASSQDIISRINSKNINNNDSNEVKRIKDALCIESKERILYPQNLSRDNLKQMARYVNNTYVHYSGNCVLLSACLHYNIHHRQDILSSKNTASPTVGLDSAIVDKIIFGHELNQSYCLNSIDEVEKEILNRYDIKRESSFIISAENYIAPIIGECRHDFNAVVICEYDKKPYVQFIDSWKTSNILPSLQEIKKHFSSSGEFYVRAYDEKHD Kraken2_NZ_CP051377.1 IMICODJL_32152 Prodigal:2.6 73528 74253 - VFG000438(gb|NP_490528) 100.0 2.2e-178 (spvC) type III secretion system effector SpvC, phosphothreonine lyase VF0947 TTSS-2 secreted effectors VFC0086 Effector delivery system GogB; PipB; PipB2 (Directly binds kinesin, a plus end-directed microtubule motor protein. Localizes to the phagosome; Promotes Sif extension, recuits kinesin-1 to SCV. ); SifA (GEF. Localizes to the cytosolic face of the SCV and binds to host protein-kinesin-binding protein SKIP to modulate phagosome tubulation; required for SCV membrane integrity and Sif formation; maintains perinuclear SCV positioning; redirects exocytic vesicles to SCV. ); SifB (GEF, WxxxE family. ); SopD2 (Inhibits vesicle transport from the vacuole; down-modulates the formation of tubular structures. ); SpiC/ssaB (SsaL/ssaM/spiC regulatory complex, sensing host cell signals to activate effector secretion. ); SpvB (ADP-ribosyltransferase. Causes cytoskeletal disruption and apoptosis. ); SpvC; SpvD; SseF (Localizes to the phagosome, contributes to Sif formation; recruits dynein to SCV; maintains perinuclear SCV positioning; required for formation of microtubule bundles around SCV; redirects exocytic transport vesicles to SCV. ); SseG (Same as SseF. ); SseI/srfH (Blocks the migration of host immune cells by associating with host protein IQGAP1, an important regulator of cell migration; attenuates the host's ability to clear systemic bacteria. ); SseJ (Glycerophospholipid-cholesterol acyl transferase and deacylase. SseJ and SifA interact in a protein complex with SKIP and RhoA family GTPases as a mechanism to promote phagosome tubulation. ); SseK1; SseK2; SseL (Deubiquitinase. Required for Salmonella-induced delayed cytotoxicity of macrophages. ); SspH2 (Novel E3 ubiquitin-ligase. Specifically localizes to the brush border of polorized epithelial cells. ); SteC (Serine/Threonine kinase. Required for SPI-2 dependent F-actin remodelling. ) MPINRPNLNLNIPPLNIVAAYDGAEIPSTNKHLKNNFNSLHNQMRKMPVSHFKEALDVPDYSGMRQSGFFAMSQGFQLNNHGYDVFIHARRESPQSQGKFAGDKFHISVLRDMVPQAFQALSGLLFSEDSPVDKWKVTDMEKVVQQARVSLGAQFTLYIKPDQENSQYSASFLHKTRQFIECLESRLSENGVISGQCPESDVHPENWKYLSYRNELRSGRDGGEMQRQALREEPFYRLMTE Kraken2_NZ_CP051377.1 IMICODJL_32153 Prodigal:2.6 74534 76309 - VFG000439(gb|NP_490529) 100.0 0.0 (spvB) type III secretion system effector SpvB, ADP-ribosylation activity VF0107 SpvB VFC0235 Exotoxin PDB accession: 2GWL SpvB-mediated actin depolymerization is associated with an accumulation of cells in the G2/M phase, eventually resulting in apoptotic cell death An ADP-ribosylating toxin that modifies actin directly and totally disrupt the cytoskeleton of the cell MLILNGFSSATLALITPPFLPKGGKALSQSGPDGLASITLPLPISAERGFAPALALHYSSGGGNGPFGVGWSCATMSIARRTSHGVPQYNDSDEFLGPDGEVLVQTLSTGDAPNPVTCFAYGDVSFPQSYTVTRYQPRTESSFYRLEYWVGNSNGDDFWLLHDSNGILHLLGKTAAARLSDPQAASHTAQWLVEESVTPAGEHIYYSYLAENGDNVDLNGNEAGRDRSAMRYLSKVQYGNATPAADLYLWTSATPAVQWLFTLVFDYGERGVDPQVPPAFTAQNSWLARQDPFSLYNYGFEIRLHRLCRQVLMFHHFPDELGEADTLVSRLLLEYDENPILTQLCAARTLAYEGDGYRRAPVNNMMPPPPPPPMMGGNSSRPKSKWAIVEESKQIQALRYYSAQGYSVINKYLRGDDYPETQAKETLLSRDYLSTNEPSDEEFKNAMSVYINDIAEGLSSLPETDHRVVYRGLKLDKPALSDVLKEYTTIGNIIIDKAFMSTSPDKAWINDTILNIYLEKGHKGRILGDVAHFKGEAEMLFPPNTKLKIESIVNCGSQDFASQLSKLRLSDDATADTNRIKRIINMRVLNS Kraken2_NZ_CP051377.1 IMICODJL_32163 Prodigal:2.6 83871 84611 - VFG002301(gb|NP_490536) 100.0 2.74e-170 (mig-5) putative carbonic anhydrase VF0396 Mig-5 Macrophage-inducible gene-5 VFC0325 Antimicrobial activity/Competitive advantage Mig-5 was found to be expressed by Salmonella when ingested by macrophages. mig-5 codes for the carbonic anhydrase which catalyses the hydratation of carbon dioxide and formation of HCO3-. The biological meaning of this reaction in intracellularilly residing of Salmonella is, however, not known. MEQNQPAQPSRRAILKQTLAVSALSVTGLAALSVPTISFAASLSKEERDGMTPDAVIEHFKQGNLRFRENRPAKHDYLAQKRNSIAGQYPAAVILSCIDSRAPAEIVLDAGIGETFNSRVAGNISNRDMLGSMEFACAVAGAKVVLVIGHTRCGAVRCAIDNAELGNLTGLLDEIKPAIAKTEYSGERKGSNYDFVDAVARKNVELTIENIRKNSPVLKQLEDEKKIKIVGSMYHLTGGKVEFFEV Kraken2_NZ_CP121069.1 IMICODJL_32323 Prodigal:2.6 38204 38524 + VFG042448(gb|AAA23663) 68.0 4.25e-36 (daaA) DaaA protein VF0212 Afa/Dr family VFC0001 Adherence Afa/Dr family including afimbrial adhesins AfaE-I, AfaE-III and Dr-II as well as the fimbrial Dr and F1845 adhesins Receptor is the DAF (decay-accelerating factor (CD55)), a cell-surface glycosylphosphatidylinositol-anchored protein that normally protect cells from damage by complement system. The third short consensus repeat (SCR-3) domain of DAF plays a pivotal role in binding adhesins; another receptor is the membrane-associated GPI-anchored protein, the carcinoembryonic antigen (CEA), which belongs to CEACAMs family; inducing a cytopathic effect characterized by the development of long cellular extensions that wrap around the adherent bacteria. (All members of the Dr family including UPEC elicit this effect); binding of Dr adhesins is accompanied by the activation of several signal transduction cascades, including activation of PI-3 kinase MSGQDSYLLLTRSFGKSLIPGEMPEIHFWLLVEVSPIHSEKVIQSLKDHLVLGYTRVEACERHHVSPGYFSGALKRLQRVNQTVSRLMPYYIPQGEFTGQTIPVIC Kraken2_NZ_CP121069.1 IMICODJL_32324 Prodigal:2.6 38569 39108 + VFG034595(gb|WP_000708866) 84.0 2.25e-100 (faeC) FaeC VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MKKIKIFYLLLLAGGGLSHASVQKILFSADVVASACHVVVDADGTGSSRLTFGTYRKSSAAPVSPRDFTVRLYETGATVQGCSAFLAGQIATLNFGNPGQLDGQGVVTRGAGDGIRIDVRAADTQADFRGRITQANHAVKYPVDFAARGQFRFHAQPVFPADVKAGEYSGALTFVVTYQ Kraken2_NZ_CP121069.1 IMICODJL_32325 Prodigal:2.6 39133 40737 + VFG042494(gb|CAA50786) 85.4 1.64e-319 (cshB) cshB porin (usher) VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MRLMRMSPEERGARRTALALATAVALGSGTASAGEKLDMSFIQGGAGINPEVWAALNGDYAPGRYLVDLSLNGKEAGKHILDVTPQDSEALCLSEAWLAKAGIYVSAEYFREGYDATRQCYVLAKAPAVKVDFDVATQSLSLAIPQKGLVKMPENVEWDYGTEAFRMNYNANANTGRNNSSAFGSADLNANIGRWVVSSSATASTGDGGNNDATINMFTATRAIRSLSADLAVGKTSTGDSLLGSTGTYGVSLSRNNSMKPGNLGYTPVFSGIANGPSRVTLTQNGRTLYSGMMPAGPFSVTDVPLYSSGDVTMTVTGDDGREQTQVFPLSVMAGQLSPGQHEFSVAAGIPDDDSDLEGGVFAASYGYGLDGLTLRTGGVFNQDWQGASAGAVLGLGYLGALSTDGAYATAKYRDGSRRGNKVQVAWSKQLELTNTGLRVSWSRQSAEYEDMSSFNPAETWLQQNQGRRTRDEWNAGISQPVGGLFSLSASGWQRSYYPASTTGSYRYADDNGKETGITGTLSTQIKSVSLNLG Kraken2_NZ_CP121069.1 IMICODJL_32327 Prodigal:2.6 41582 42373 + VFG034597(gb|WP_000044493) 88.7 1.07e-156 (faeE) fimbrial chaperone FaeE VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MTMKQTQKMRSFFRNRVTKALGMTLALMMASQSALASLAADQTRYIFRGDKDALTITVTNNDKERTFGGQAWVDNIVEKDTRPTFVVTPSFFKVKPQGQQTLRIIMASDHLPKDKESVYWLNLQDIPPALKGSGIAIALRTKLKLFYRPEALLKDRKGAEEGISLQVRPDGRTMLVNTTPYIYAIGSLLDANGKKVAVDNDTAQKLLMFMPGDEVQVKGNVVKVDSLNDYGELQTWTINQKKVAAPEAKTVPETKTAAGAGKK Kraken2_NZ_CP121069.1 IMICODJL_32328 Prodigal:2.6 42406 42900 + VFG034598(gb|WP_000753462) 71.0 5.82e-72 (faeF) fimbrial protein FaeF VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MMKKALMAVALFSALPVLAADYSEKTQYLGVVNGQVVGNSVVKVTRTPADPVLYRTESNGPLPETLVIRNAESRPASGNMVYITVKRTLGDGRDARLTLKTTLMVDGQRAALSASQRGEDVVITVPAATRQVELRSDAPAELEVPANYRGNVQVPVEVEGVSVS Kraken2_NZ_CP121069.1 IMICODJL_32330 Prodigal:2.6 44110 44901 + VFG034600(gb|WP_000704731) 77.1 2.21e-146 (faeH) fimbrial protein FaeH VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MKITHHYKSIISALAALALFYSAAPRAGILDGGEIQFHGLVTDEAPKWTWQVGSPDQTWAVDTADARNENGFLVFDLRSKGTLPFLEGHLYEVAERGGPGFTPFITFSSNGQPFSVTAGGSTTAQHFRASVPVRNPENGHVAGQLSFTLDQGMAVSAGHQEDGAVLPAGMSLVNGQSVSGVQAGTLPQWLKSRLPSLLMLNRGFGNGMSTADNGQVISQGVLADARVTQLAAAYASAVSDFELRLPAENTPAQWQAGLSVTVQ Kraken2_NZ_CP121069.1 IMICODJL_32331 Prodigal:2.6 44929 45693 + VFG043644(gb|AAA23586) 66.9 6.15e-125 (clpL) CS31A minor subunit VF1147 CS31A capsule-like antigen VFC0001 Adherence MKRMTILLLAASLLPSCVLAWNTPGEDFSGELKLGGPVTSTRNPWVWKVGEGNTQINTKAHSVLRSGEQVIPVPLPAMTVLLGKTILTTPAGREGLAPQVTYGNGTEGFALMWTAPGTASVTLPVTGEGNVRTGTFSFRLQTAGVLRHVRGDRAEYAGLYDDLQGNGLPAQGQVMPAEQTPGVLQTLFDSEGPAWLREMTVSSVTGLSRFSDAALRQVDGVYGAQTVADSGELRFKGEIPSRWHTSLAVSIEYR Kraken2_NZ_CP121069.1 IMICODJL_32389 Prodigal:2.6 99382 101403 - VFG012567(gb|WP_000784549) 97.6 0.0 (fyuA) siderophore yersiniabactin receptor FyuA VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MKMTRLYPLALGGLLLPAIANAQTSQQDESTLVVTASKQSSRSASANNVSFTVVSAPELSDAGVTASDKLPKVLPGLNIENSGNMLFSTISLRGVSSAQDFYNPAVTLYVDGVPQLSTNTIQALTDVQSVELLRGPQGTLYGKSAQGGIINIVTRQPDNTPRGYIEGGVSSRDSYRSKLNLSGPIQDGLLYGSVTLLRQVDDGDMINPATGSDDLGGTRASIGNVKLRLAPDDQPWEIGFAASRECTRATQDAYVGWNDIKGRKLSISDGLPDPYMRRCTDSQTLSGKYTTDDWVFNLISAWQQQHYSRTFPSGSLIVNMPQRWNQDVQELRAATLGDARTVDMVFGLYRQNTREQMQATYDMPTMRYLTSAGYTTAETLAAYSDLTWHLTDRFDIGGGVRFSHDKSSTQYHGSMRGNPFGDQGKSNDDQVLGQLSAGYMLTDDWRVYTRVAQGYKPSGYNIVPTAGLDAKPFVAEKSINYELGTRYETADVTLQAATFYTHTKDMQLYSGPVGMQTLSNAGKADATGVELEAKWRFAPGWSWDINGNVIRSEFTNDSELYHGNRVPFVPRYGAGSSVNGVIDTRYGALMPRLAVNLVGPHYFDGDNQLRQGTYATLDSSLGWQATERMNISVYVDNLFDRRYRTYGYMNGSSAVAQVNMGRTVGINTRIDFF Kraken2_NZ_CP121069.1 IMICODJL_32390 Prodigal:2.6 101534 103111 - VFG048593(gb|WP_014907267) 97.3 0.0 (ybtE) yersiniabactin biosynthesis salycil-AMP ligase YbtE VF0564 Ybt Yersiniabactin VFC0272 Nutritional/Metabolic factor Ybt is the most common virulence factor associated with human K. pneumoniae infections The phenolate siderophore Ybt contributes to evasion of the activity of lipocalin2 in the lung – a host factor which neutralizes enterobactin-based iron acquisition MNSSFESLIEQYPLPIAEQLRHWAARYASRIAVVDAKGSLTYSALDARVDELAAGLSSLGLRSGEHVIVQLPNDNAFVTLLFALLRLGVIPVLAMPSQRALDIDALVELAQPVAYVIHGENHAELARQMAHKHACLRHVLVAGETVSNDFTPLFSLHGEQQAWPQPDVSATALLLLSGGTTGTPKLIPRRHADYSYNFSASAELCGISQQSVYLAVLPVAHNFPLACPGILGTLACGGKVVLTDSASCDEVMPLIAREGVTHVALVPALAQLWVQAREWEDSDLSSLRVIQAGGARLDPALAEQAIATFDCTLQQVFGMAEGLLCFTRLDDPHTTILHSQGRPLSPLDEIRIVDQNENDVAPGETGQLLTRGPYTISGYYRAPAHNAQAFTTQGFYRTGDNVRLDEAGNLHVEGRIKEQINRAGEKIAAAEVESALMRLAEVQDCAVVAAPDTLLGERICAFIIAQQVPTDYQQLRQQLTRMGLSAWKIPDQIEFLAHWPLTAVGKIDKKRLTALAIDRYRHSAQ Kraken2_NZ_CP121069.1 IMICODJL_32391 Prodigal:2.6 103115 103918 - VFG034147(gb|WP_000194282) 98.1 4.4800000000000005e-200 (ybtT) yersiniabactin biosynthesis thioesterase YbtT VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MTQSAMCIPLWPARNGNTAHLVMCPFAGGSSSAFRHWQAEQLADCALSLVIWPGRDRLRHLEPLRSITQLAALLTNELEASVSPDTPLLLAGHSMGAQVAFETCRLLEQQGHAPQGLIISGCHAPHLHSERQLSHRDDADFIAELIDIGGCSPELRENQELMSLFLPLLRADFDATESYHYDSPDVCPPLRTPALLLCGSHDREASWQQVDAWRQWLSHVTGPVVIDGDHFYPIQQARSFFTQIVRHFPHAFSAMTALQKQPSTSER Kraken2_NZ_CP121069.1 IMICODJL_32392 Prodigal:2.6 103915 105015 - VFG034135(gb|WP_000982866) 98.1 5.55e-278 (ybtU) yersiniabactin biosynthesis oxidoreductase YbtU VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MMPSASPKQRVLIVGAKFGEMYLNAFMQPPEGLELVGLLAQGSARSRELAHAFGIPLYTSPEQITRMPDIACIVVRSTVAGGTGTQLARHFLARGVHVIQEHPLHPDDISSLQTLAQEQGCCYWVNTFYPHTRAGRTWLRDAQQLRRCLAKTPPVVHATTSRQLLYSTLDLLLLALGVDAVAVECDVVGSFGDFHCLRLFWPKGEACLLLQRYLDPDDPDMHSLIMHRLLLGWPEGHLSLEASYGPVIWSSSLFVADHQENAHSLYRRPEILRDPPGLTRSAAPLSWHDCCETVGPEGVSWLLHQLRSHLAGEHPPAACQSVHQIALSRLWQQILRQTGNAEIRRLTPPHHDRLAGFYNDDDKEAL Kraken2_NZ_CP121069.1 IMICODJL_32393 Prodigal:2.6 105012 114509 - VFG000362(gb|WP_002212777) 97.3 0.0 (irp1) yersiniabactin biosynthetic protein Irp1 VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MDNLRFSSAPTADSIDASIAQHYPDCEPVAVIGYACHFPESPDGETFWQNLLEGRECSRRFTREELLAVGLDAAIIDDPHYVNIGTVLDNADCFDATLFGYSRQEAESMDPQQRLFLQAVWHALEHAGYAPGAVPHKTGVFASSRMSTYPGREALNVTEVAQVKGLQSLMGNDKDYIATRAAYKLNLHGPALSVQTACSSSLVAVHLACESLRAGESDMAVAGGVALSFPQQAGYRYQPGMIFSPDGHCRPFDASAEGTWAGNGLGCVVLRRLRDALLSGDPIISVILSSAVNNDGNRKVGYTAPSVAGQQAVIEEALMLAAIDDRQVGYIETHGTGTPLGDAIEIEALRNVYAPRPQDERCALGSVKSNMGHLDTAAGIAGLLKTVLAVSRGQIPPLLNFHTPNPALKLEESPFTIPVSAQAWQDEMRYAGVSSFGIGGTNCHMIVASLPDALNARLPNTDGGRKSTALLLSAASDSALRRLATDYAGALRDNADASSLAFTALHARRLDLPFRLAAPLNRETAAALSAWAGEKSGELVYSGHGASGKQVWLFTGQGSHWRTMGQTMYRHSTAFADTLDRCFSACSEMLTPSLREAMFNPDSAQLDNMAWAQPAIVAFEIAMAAHWRAEGLKPDFAIGHSVGEFAAAVVCGHYTIEQVMPLVCRRGALMQQCASGAMVAVFADEDTLMPLARQFELDLAANNGTQHTVFSGPEARLAIFCATLSQHDIDYRRLSVTGAAHSALLEPILDRFQAACAGLHAEPGQIPIISTLTADVIDESTLNQADYWRRHMRQPVRFIQSIQMAHQLGARVFLEMGPDAQLVASGQREYRDNAYWIASARRNKEANDVLNQALLQLYAAGVALPWANLLAGDGQRIAAPCYPFDTERYWKERVSPACEPADAALSAGLEVASRAAAALDHPRLEALKQCATRLHAIYVDQLVQRCTGDAIENGVDAMTIMRRGRLLPRYQQLLQRLLNNCVVDGDYRCTDGRYARARPIEHQQRESLLTELAGYCEGFQAIPDTIARAGDRLYEMMSGAEEPVAIIFPQSASDGVEVLYQEFSFGRYFNQIAAGVLRGIVQTRQPRQPLRILEVGGGTGGTTAWLLPELSGVPALEYHFTDISALFTRRAQQKFADYDFVKYSELDLEKEAQSQGFLAQSYDLIVAANVIHATRHIGRTLDNLRPLLKPGGRLLMREITQPMRLFDFVFGPLVLPLQDLDAREGELFLTTAQWQQQCRHAGFSKVAWLPQDDSPTAGMSEHIILATLPGQAVSAVTFTAPSEPVLGQALTDNGDYLADWSDCAGQPEQFNARCQEAWRLLSQRHGDALPVEPPLAAAPEWLGEVRLSWQNEAFSRGQMRVEARHPDGKWLPLSPAAPLPAPQTHYQWRWTPLNIASADHPLTFNFSAGMLARRDELAQYGIIHDPHASSRLMIVEESEDTLALAEKVIAALTASAAGLIVVTRRAWRVEENEALSASHHALWALLRVAANEQPERLIAAIDLAENTPWETLHQGLSAVSLSQRWLAARGNTLWLPSLAPNTGCAAELPANVFTGDNRWHLVTGAFGGLGRLAVNWLREKGARRIALLAPRVDESWLRDVEGGQTRVCRCDVGDTGQMTTVLDDLAANGGIAGAIHAAGVLADAPLQELDDHQRAAVFAVKAQAANQLLQTLRNHDGRYLILYSSAAATLGAPGQSAHALACGYLDGLAQQFSTLDAPKTLSVAWGAWGESGRAATPEMLATLANRGMGALSDAEGCWHLEQAVMRGTPWRLAMRVFTDKMPPLQQALFNISATEKAATPVIPPADDNAFNGSLSDETAVMAWLKKRIAVQLRLSNPASLRPNQDLLQLGMDSLLFLELSSDIQHYLGVRINAERAWQDLSPHGLTQLICSKPETTPAASQPEVLRHDADERYAPFPLTPIQHAYWLGRTHLIGYGGVACHVLFEWDKRHDEFDLAILEKAWNQLIARHDMLRMVVDADGQQRVLATTPEYHIPRDDLRALSPEEQRIALEKRRHELSYRVLPADQWPLFELVVSKIDDCHYRLHMNLDLLQFDVQSFKVMMDDLAQVWRGETLAPLDITFRDYVMAEQARRQTSAWHDAWDYWQEKLPQLPLAPELPVVETPPETPHFTTFKSTIGKKEWQAVKQRWQQQGVTPSAALLTLFAATLERWSRTTAFTLNLTFFNRQPIHPQINQLIGDFTSVTLVDFNFSTPVTLQEQMQQTQQRLWQNMAHSEMNGVEVIRELGRLRGSQRQPLMPVVFTSMLGMTLEGMTIDQAMSHLFGEPCYVFTQTPQVWLDHQVMESDGELMFSWYCMDNVLEPGAAEAMFNDYCAILQAVIAAPESLKTLASGIAGHIPRRRWPLNAQTDYDLRDIEQATLEYPGIRQTRAEIAEQGALTLDIVMVDDPSPSAATPDEHDLAQLALALPLPAQVQLDELEATWRWLEARALQGIAATLNRHGLFTTPEIAHRFSAIVQALSAQASHQRLLRQWLQCLTEREWLIREGESWRCRVPLSEIPEPQEACPQSQWSQALAQYLETCIARHDALFSGQCSPLELLFNEQHRVTDALYRDNPASACLNRYIAQIAALCGAERILEVGAGTAATTAPVLQATRNTRQSYHFTDVSAQFLNDARARFHDESRVSYALFDINQPLDFTAHPEAGYDLIVAVNVLHDASHVVQTLRRLKLLLKAGGRLLIVEATERNSVFQLASVGFIEGLSGYRDFRRRDEKPMLTRSAWQEVLVQAGFTNELAWPTQESSPLRQHLLLARSPGVNRPNKEAVSRYLQQRFGTGLPVLQIRQRETLFTPQHAPSDALIEPPKPTPVAGGNPALEKQVAELWQSLLSRPVARHHDFFELGGDSLMATRMVAQLNRRGIARANLQDLFSHSTLSDFCAHLQAATSGEDNPVPLCQGDGEETLFVFHASDGDISAWLPLASALNRRVFGLQAKSPLRFATLDQMIDEYVGCIRRQQPHGPYVLAGWSYGAFLAAGAAQRLYAKGEQVRMVLIDPVCRQDFCCDNRAALLRLLAEEQTPLALPEHFDQQTPDSQLADFIGLAKTAGMVSQNLTLQAAETWLDNIAHLLRLLTEHTPGESVPVPCLMVYAAGRPARWTPAETEWQGWINNADGYVIEASHWQIMMEAPHVQACAQHITRWLCATSTQLENTL Kraken2_NZ_CP121069.1 IMICODJL_32394 Prodigal:2.6 114597 120704 - VFG000363(gb|WP_002212775) 97.7 0.0 (irp2) yersiniabactin biosynthetic protein Irp2 VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MISGAPSQDSLLPDNRHAADYQQLRERLIQELNLTPQQLHEESNLIQAGLDSIRLMRWLHWFRKNGYRLTLRELYAAPTLAAWNQLILSRSPENAEEETPPDESSWPNMTESTPFPLTPVQHAYLTGRMPGQTLGGVGCHLYQEFEGHCLTASQLEQAITALLQRHPMLHIAFRPDGQQIWLPQPYWNGVTVHDLRHNDAESRQPYLEALRQRLSHRLLRVEIGETFDFQLTLLPDNRHRLHVNIDLLIMDASSFTLFFDELNALLAGESLSAIDTRYDFRSYLLHQQKINQPLRDNARAYWLAKASTLPPAPVLPLTCEPATLREVRNTRRRMIVPATRWHAFSNRAGEYGVTPTMALATCFSAVLARWGGLTRLLLNITLFDRQPLHPSVGAMLADFTNILLLDTACDGDTVSNLARKNQLTFTEDWEHRHWSGVELLRELKRQQRYPHGAPVVFTSNLGRSLYSSRAESPLGEPEWGISQTPQVWIDHLAFEHHGEVWLQWDSNDALFPPALVETLFDAYCQLINQLCDDESAWQKPFADMMPARQRAIRERVNATGAPIPEGLLHEGIFRIALQQPQALAVTDMRYQWNYYELTDYARRCAGRLIECGVQPGDNVAITMSKGAGQLVAVLAVLLAGAVYVPVSLDQPAARREKIYADASVRLVLICQHDASAWSDDIPVLAWQQAIEAEPIANPVVRAPTQPAYIIYTSGSTGTPKGVVISHRGALNTCCDINTRYQVGPGDRVLALSALHFDLSVYDIFGVLRAGGVLVMVMENQRRDPHAWCELIQRHQVTLWNSVPALFDMLLTWCEGFADATPENLRAVMLSGDWIGLDLPARYRAFRPQGQFIAMGGATEASIWSNACEIHDVPAHWRSIPYGFPLTNQRYRVVDEWGRDCPDWVPGELWIGGIGVAEGYFNDPLRSEQQFLTHPDERWYRTGDLGCYWPDGTIEFLGRRDKQVKVGGYRIELGEIESALSQLAGVKQATVLAIGEKEKTLAAYVVPQGEAFCVTDHRDPALPQAWHTLAGTLPCCAISPEISAEQVADFLQHRLLKLKPGHTAGADPLPLMNSLAIQPRWQAVVERWLAFLVTQRRLKPAAEGYQVCAGEERKDEHPNFSGHDLTLSQILRGTRDELSLLNDAQWSPESLAFNHPASAPYIQELATICQQLAQSLQRPVRLLEVGTRTGRAAESLLVQLNAGQVEYVGLEQSQEMLLSARQRLVPRLGARLSPWNADTLAVHAHSADIIWLNNALHRLLPEDPGLLATLQQLAVPGALLYVMEFRQLTPSALLSTLLLTDGQPEALLHNSADWAALFSAAAFNCQHGDEVAGLQRFLVQCPDSQVRRDPRQLQAALAGRLPGWMVPQRIVFLDALPLTANGKIDYQALKRRHTPEAENQAEADLPQGDTEKQVAALWQQLLSTGNVTRETDFFQQGGDSLLATRLTGQLHQAGYEAQLSDLFNHPRLADFAATLRKIDVPVEQPFVHSPEDRYQPFALTDVQQAYLVGCQPGFALGGVGSHFFVEFEIADLDLTRLETVWNRLIARHDMLRAVVRDGQQQVLEQTPHWVIPAHTLHTPEEALRAREKLAHQVLNPEVWPVFDLQVGYVNGMPARLWLCLDNLLLDGLSMQILLAELEHGYRYPQQLPPPLPVTFRDYLQQPSLQSPNPDSLAWWQAQLDDIPPAPALPLRCLPQEVETPRFTRLNGALDSTRWHRLKKRAADAHLTPSAVLLSVWSTVLSAWSAQPEFTLNLTLFDRRPLHPQINQILGDFTSLMLLSWHPGESWLHSAQSLQQRLSQNLNHRDVSAIRVMRQLAQRQNVPAIPMPVVFTSALGFEQDNFLARRNLLKPVWGISQTPQVWLDHQVYESEGELRFNWDFVAALFPAGQVERQFEQYCALLNRMAEDESGWQLPLAALVPPVKFAGQCAERSPRVCPEHSQPHIAADESTVSLICDAFREVVGESVTPAENFFEAGATSLNLVQLHILLQRHEFSTLTLLDLFTHPSPAALADYLAGVVTVEKTKHPRPVRRRQRRI Kraken2_NZ_CP121069.1 IMICODJL_32395 Prodigal:2.6 120895 121854 - VFG034084(gb|WP_000140406) 98.4 9.33e-235 (ybtA) yersiniabactin transcriptional regulator YbtA VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MTESPQTQSEISIHQLVIGKPANDGNIPAQCELLRCSLQEGMDILLWRGHFARPETLQLHDDLGRINFSCILEGTSRFAIQGLRRHTDWELARNRHYITHTPDCRGSASYCGRFESITLSFSPETLALWVPDINAVIKNKIDSQCCCQQQRCNAETHLTAQTLRHALMRMHGGFSHEQKPSTLWLQGQSLVMLSLVLDEHREDASCLSCHFNPMERQKLLRAKDLLLADLTQAPGVAELARESGLSVLKIKRGFRVLFNNSVYGLFQAERMQEARRRLANGNTSVMTVAADLGYANASHFSTAFQKQFGVTPSTFKRVM Kraken2_NZ_CP121069.1 IMICODJL_32396 Prodigal:2.6 122222 124024 + VFG012539(gb|WP_001327262) 98.2 0.0 (ybtP) yersiniabactin ABC transporter ATP-binding/permease protein YbtP VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MSSQSSNTESLSRFPLWQVITPVRRKVILAMALAGLAALTSLGALLFLAWSLRDLRATPDAIPAWPLGGVIGCVVLTFVLRLQAFNTSHYAAFHLENILRSRLARKALQLPPGVLQQMGSGSVAKVMLDDVKSLHIFVADSTPLYARAIIMPLATIVILFWLDWRLAIATLGVLAFGSVVLVLARQRSEDMAQRYHKAREQVSAAVIEFVQAMPVVRTFDSGSTSFLRYQRALEEWGDVLKTWYHKAGFSARFSFSILNPLPTLVVLIWSGYGLLHYGSLDFTAWVAVLLLGSGMAEAVMPMMMLNNLVAQTRLSIQRIYQVLAMPELSLPLSDQQPKEASITFEQVSFHYPQARTGAALQEVSFHVPAGQIVALVGPSGAGKSTVARLLLRYADPDKGHIRIGGVDLRDMQTDTLMKQLSFVFQDNFLFADTIANNIRLGAPDTPLEAVIAAARVAQAHDFISVLPEGYNTRVGERGVFLSGGQRQRITIARAILQDRPILVLDEATAFADPENEAALIKALAAAMRGRTVIMVAHRLSMVTQADVILLFSDGQLREMGNHTQLLAQGGLYQRLWQHYQQAQHWVPGGTQEEVVENERQ Kraken2_NZ_CP121069.1 IMICODJL_32397 Prodigal:2.6 124011 125813 + VFG003507(gb|WP_005168689) 97.3 0.0 (ybtQ) yersiniabactin ABC transporter ATP-binding/permease protein YbtQ VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MKDNNPADNLAWRVIWRQLISSVGSQARMLRRSMLALLLAAFMQGVAFACLYPIIDALLRGDAPQLLNWAVAFSVATIVTLALRWYGLGFEYRGHLAQATHELRLRLGEQLRRVPLEKLQRGRAGEMNALLLGSVDENLNYVIAIANILLLTIITPLTASLATWWIDWRLGLVMLLIFPLLVPFYYWRRPAMRRQMQTLGEAHQRLSGDIVEFAQGMMVLRTCGSDADKSRALLAHFNALENLQTRTHRQGAGATMLIASVVELGLQVVVLSGIVWVVTGNLNLAFLIAAVAMIMRFAEPMAMFISYTSVVELIASALQRIEQFMAIAPLPVAAQNEMPERYDIRFDNVSYCYEEGDGHALNNVSLTFPAASMSALVGASGAGKTTVTKLLMRYADPQQGQISIGGVDIRRLTPEQLNSLISVVFQDVWLFDDTLLANIRIARPQATRQAVEEAARAAQCLEFISRLPQGWLTPLGEMGGQLSGGERQRISIARALLKNAPVVILDEPTAALDIESELAVQKAIDNLVHNRTVIIIAHRLSTIAGAGNILVMEEGQVVEQGTHAQLLSRHGRYQALWQAQMAARAWRDEGVSASGEWVHE Kraken2_NZ_CP121069.1 IMICODJL_32398 Prodigal:2.6 125806 127086 + VFG034033(gb|WP_001286280) 97.9 8.659999999999999e-285 (ybtX) yersiniabactin-associated zinc MFS transporter YbtX VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MSDVQSNVKPLTLTTGRVIFAIAGVYVTQSLVSALSMQSLPALVRAAGGSLALAGATTLFMLPWALKFIWAPWIERWRLPPGSPERRSRMLILRGQVALAAILTIAAAIGWFGREGGFPDTQIVALFVLFMVAGTVASTIDIASDGFCVDQLTRAGYGWGNSVQVGGSYLGMMCGGGVFLMLSAASGWPVAMLMMAVLIMALSLPLWRITEPTRTETIPHIPALGYALRRKQARLGLLLVLMLNSGMRFVLPLLAPLLLDHGLSMSALGALFSGGNIAAGIAGTLAGGLLMKYTSPGRALLMTYGVQGIALLAVVMTLMMVPGHLLLPILQCLVIVQSISLACALVCLYATLMSLSSPLQAGVDFTLFQCTDAAIAILAGVIGGVVAQHFGYATCFLFAGAFTLLAAWVAYIRLYSARELMTSAID Kraken2_NZ_CP121069.1 IMICODJL_32399 Prodigal:2.6 127114 128445 + VFG012529(gb|WP_000703040) 95.8 2.17e-305 (ybtS) yersiniabactin biosynthesis salicylate synthase YbtS VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MKISEFLHLALPEEQWLPTISGVLRQFAEEECYVYECQPCWYLGKGCQVRLHINADGTQATFIDDAGEQQWAVDSIADCARRFMAHPQVKGRRVYGQVGFNFAAHAREIAFNAGEWPLLTLTVPREELIFEKGNVTVYADSADGCRRLCEWVKEARTTTQNAPLAVDTALNGEMYKQQVARAVAEIRRGEYAKVIVSRAIPLPSRIDMPATLLYGRQANTPTRSFMFRQEGREALGFSPELVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIVELESICQAGSVVVEDLMSVRQRGSVQHLGSSVSGNLAENKDAWDAFTALFPSITASGIPKNAALNAIMQIETTPRELYSGAILLLDDTRFDAALVLRSVFQDSQRCWIQAGAGIIAQSTPERELMETREKLASIVPYLMAAKLKAGVME Kraken2_NZ_CP121077.1 IMICODJL_32517 Prodigal:2.6 38204 38524 + VFG042448(gb|AAA23663) 68.0 4.25e-36 (daaA) DaaA protein VF0212 Afa/Dr family VFC0001 Adherence Afa/Dr family including afimbrial adhesins AfaE-I, AfaE-III and Dr-II as well as the fimbrial Dr and F1845 adhesins Receptor is the DAF (decay-accelerating factor (CD55)), a cell-surface glycosylphosphatidylinositol-anchored protein that normally protect cells from damage by complement system. The third short consensus repeat (SCR-3) domain of DAF plays a pivotal role in binding adhesins; another receptor is the membrane-associated GPI-anchored protein, the carcinoembryonic antigen (CEA), which belongs to CEACAMs family; inducing a cytopathic effect characterized by the development of long cellular extensions that wrap around the adherent bacteria. (All members of the Dr family including UPEC elicit this effect); binding of Dr adhesins is accompanied by the activation of several signal transduction cascades, including activation of PI-3 kinase MSGQDSYLLLTRSFGKSLIPGEMPEIHFWLLVEVSPIHSEKVIQSLKDHLVLGYTRVEACERHHVSPGYFSGALKRLQRVNQTVSRLMPYYIPQGEFTGQTIPVIC Kraken2_NZ_CP121077.1 IMICODJL_32518 Prodigal:2.6 38569 39108 + VFG034595(gb|WP_000708866) 84.0 2.25e-100 (faeC) FaeC VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MKKIKIFYLLLLAGGGLSHASVQKILFSADVVASACHVVVDADGTGSSRLTFGTYRKSSAAPVSPRDFTVRLYETGATVQGCSAFLAGQIATLNFGNPGQLDGQGVVTRGAGDGIRIDVRAADTQADFRGRITQANHAVKYPVDFAARGQFRFHAQPVFPADVKAGEYSGALTFVVTYQ Kraken2_NZ_CP121077.1 IMICODJL_32519 Prodigal:2.6 39133 40737 + VFG042494(gb|CAA50786) 85.4 1.64e-319 (cshB) cshB porin (usher) VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MRLMRMSPEERGARRTALALATAVALGSGTASAGEKLDMSFIQGGAGINPEVWAALNGDYAPGRYLVDLSLNGKEAGKHILDVTPQDSEALCLSEAWLAKAGIYVSAEYFREGYDATRQCYVLAKAPAVKVDFDVATQSLSLAIPQKGLVKMPENVEWDYGTEAFRMNYNANANTGRNNSSAFGSADLNANIGRWVVSSSATASTGDGGNNDATINMFTATRAIRSLSADLAVGKTSTGDSLLGSTGTYGVSLSRNNSMKPGNLGYTPVFSGIANGPSRVTLTQNGRTLYSGMMPAGPFSVTDVPLYSSGDVTMTVTGDDGREQTQVFPLSVMAGQLSPGQHEFSVAAGIPDDDSDLEGGVFAASYGYGLDGLTLRTGGVFNQDWQGASAGAVLGLGYLGALSTDGAYATAKYRDGSRRGNKVQVAWSKQLELTNTGLRVSWSRQSAEYEDMSSFNPAETWLQQNQGRRTRDEWNAGISQPVGGLFSLSASGWQRSYYPASTTGSYRYADDNGKETGITGTLSTQIKSVSLNLG Kraken2_NZ_CP121077.1 IMICODJL_32521 Prodigal:2.6 41582 42373 + VFG034597(gb|WP_000044493) 88.7 1.07e-156 (faeE) fimbrial chaperone FaeE VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MTMKQTQKMRSFFRNRVTKALGMTLALMMASQSALASLAADQTRYIFRGDKDALTITVTNNDKERTFGGQAWVDNIVEKDTRPTFVVTPSFFKVKPQGQQTLRIIMASDHLPKDKESVYWLNLQDIPPALKGSGIAIALRTKLKLFYRPEALLKDRKGAEEGISLQVRPDGRTMLVNTTPYIYAIGSLLDANGKKVAVDNDTAQKLLMFMPGDEVQVKGNVVKVDSLNDYGELQTWTINQKKVAAPEAKTVPETKTAAGAGKK Kraken2_NZ_CP121077.1 IMICODJL_32522 Prodigal:2.6 42406 42900 + VFG034598(gb|WP_000753462) 71.0 5.82e-72 (faeF) fimbrial protein FaeF VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MMKKALMAVALFSALPVLAADYSEKTQYLGVVNGQVVGNSVVKVTRTPADPVLYRTESNGPLPETLVIRNAESRPASGNMVYITVKRTLGDGRDARLTLKTTLMVDGQRAALSASQRGEDVVITVPAATRQVELRSDAPAELEVPANYRGNVQVPVEVEGVSVS Kraken2_NZ_CP121077.1 IMICODJL_32524 Prodigal:2.6 44110 44901 + VFG034600(gb|WP_000704731) 77.1 2.21e-146 (faeH) fimbrial protein FaeH VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MKITHHYKSIISALAALALFYSAAPRAGILDGGEIQFHGLVTDEAPKWTWQVGSPDQTWAVDTADARNENGFLVFDLRSKGTLPFLEGHLYEVAERGGPGFTPFITFSSNGQPFSVTAGGSTTAQHFRASVPVRNPENGHVAGQLSFTLDQGMAVSAGHQEDGAVLPAGMSLVNGQSVSGVQAGTLPQWLKSRLPSLLMLNRGFGNGMSTADNGQVISQGVLADARVTQLAAAYASAVSDFELRLPAENTPAQWQAGLSVTVQ Kraken2_NZ_CP121077.1 IMICODJL_32525 Prodigal:2.6 44929 45693 + VFG043644(gb|AAA23586) 66.9 6.15e-125 (clpL) CS31A minor subunit VF1147 CS31A capsule-like antigen VFC0001 Adherence MKRMTILLLAASLLPSCVLAWNTPGEDFSGELKLGGPVTSTRNPWVWKVGEGNTQINTKAHSVLRSGEQVIPVPLPAMTVLLGKTILTTPAGREGLAPQVTYGNGTEGFALMWTAPGTASVTLPVTGEGNVRTGTFSFRLQTAGVLRHVRGDRAEYAGLYDDLQGNGLPAQGQVMPAEQTPGVLQTLFDSEGPAWLREMTVSSVTGLSRFSDAALRQVDGVYGAQTVADSGELRFKGEIPSRWHTSLAVSIEYR Kraken2_NZ_CP121077.1 IMICODJL_32583 Prodigal:2.6 99394 101415 - VFG012567(gb|WP_000784549) 97.6 0.0 (fyuA) siderophore yersiniabactin receptor FyuA VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MKMTRLYPLALGGLLLPAIANAQTSQQDESTLVVTASKQSSRSASANNVSFTVVSAPELSDAGVTASDKLPKVLPGLNIENSGNMLFSTISLRGVSSAQDFYNPAVTLYVDGVPQLSTNTIQALTDVQSVELLRGPQGTLYGKSAQGGIINIVTRQPDNTPRGYIEGGVSSRDSYRSKLNLSGPIQDGLLYGSVTLLRQVDDGDMINPATGSDDLGGTRASIGNVKLRLAPDDQPWEIGFAASRECTRATQDAYVGWNDIKGRKLSISDGLPDPYMRRCTDSQTLSGKYTTDDWVFNLISAWQQQHYSRTFPSGSLIVNMPQRWNQDVQELRAATLGDARTVDMVFGLYRQNTREQMQATYDMPTMRYLTSAGYTTAETLAAYSDLTWHLTDRFDIGGGVRFSHDKSSTQYHGSMRGNPFGDQGKSNDDQVLGQLSAGYMLTDDWRVYTRVAQGYKPSGYNIVPTAGLDAKPFVAEKSINYELGTRYETADVTLQAATFYTHTKDMQLYSGPVGMQTLSNAGKADATGVELEAKWRFAPGWSWDINGNVIRSEFTNDSELYHGNRVPFVPRYGAGSSVNGVIDTRYGALMPRLAVNLVGPHYFDGDNQLRQGTYATLDSSLGWQATERMNISVYVDNLFDRRYRTYGYMNGSSAVAQVNMGRTVGINTRIDFF Kraken2_NZ_CP121077.1 IMICODJL_32584 Prodigal:2.6 101546 103123 - VFG048593(gb|WP_014907267) 97.3 0.0 (ybtE) yersiniabactin biosynthesis salycil-AMP ligase YbtE VF0564 Ybt Yersiniabactin VFC0272 Nutritional/Metabolic factor Ybt is the most common virulence factor associated with human K. pneumoniae infections The phenolate siderophore Ybt contributes to evasion of the activity of lipocalin2 in the lung – a host factor which neutralizes enterobactin-based iron acquisition MNSSFESLIEQYPLPIAEQLRHWAARYASRIAVVDAKGSLTYSALDARVDELAAGLSSLGLRSGEHVIVQLPNDNAFVTLLFALLRLGVIPVLAMPSQRALDIDALVELAQPVAYVIHGENHAELARQMAHKHACLRHVLVAGETVSNDFTPLFSLHGEQQAWPQPDVSATALLLLSGGTTGTPKLIPRRHADYSYNFSASAELCGISQQSVYLAVLPVAHNFPLACPGILGTLACGGKVVLTDSASCDEVMPLIAREGVTHVALVPALAQLWVQAREWEDSDLSSLRVIQAGGARLDPALAEQAIATFDCTLQQVFGMAEGLLCFTRLDDPHTTILHSQGRPLSPLDEIRIVDQNENDVAPGETGQLLTRGPYTISGYYRAPAHNAQAFTTQGFYRTGDNVRLDEAGNLHVEGRIKEQINRAGEKIAAAEVESALMRLAEVQDCAVVAAPDTLLGERICAFIIAQQVPTDYQQLRQQLTRMGLSAWKIPDQIEFLAHWPLTAVGKIDKKRLTALAIDRYRHSAQ Kraken2_NZ_CP121077.1 IMICODJL_32585 Prodigal:2.6 103127 103930 - VFG034147(gb|WP_000194282) 98.1 4.4800000000000005e-200 (ybtT) yersiniabactin biosynthesis thioesterase YbtT VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MTQSAMCIPLWPARNGNTAHLVMCPFAGGSSSAFRHWQAEQLADCALSLVIWPGRDRLRHLEPLRSITQLAALLTNELEASVSPDTPLLLAGHSMGAQVAFETCRLLEQQGHAPQGLIISGCHAPHLHSERQLSHRDDADFIAELIDIGGCSPELRENQELMSLFLPLLRADFDATESYHYDSPDVCPPLRTPALLLCGSHDREASWQQVDAWRQWLSHVTGPVVIDGDHFYPIQQARSFFTQIVRHFPHAFSAMTALQKQPSTSER Kraken2_NZ_CP121077.1 IMICODJL_32586 Prodigal:2.6 103927 105027 - VFG034135(gb|WP_000982866) 98.1 5.55e-278 (ybtU) yersiniabactin biosynthesis oxidoreductase YbtU VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MMPSASPKQRVLIVGAKFGEMYLNAFMQPPEGLELVGLLAQGSARSRELAHAFGIPLYTSPEQITRMPDIACIVVRSTVAGGTGTQLARHFLARGVHVIQEHPLHPDDISSLQTLAQEQGCCYWVNTFYPHTRAGRTWLRDAQQLRRCLAKTPPVVHATTSRQLLYSTLDLLLLALGVDAVAVECDVVGSFGDFHCLRLFWPKGEACLLLQRYLDPDDPDMHSLIMHRLLLGWPEGHLSLEASYGPVIWSSSLFVADHQENAHSLYRRPEILRDPPGLTRSAAPLSWHDCCETVGPEGVSWLLHQLRSHLAGEHPPAACQSVHQIALSRLWQQILRQTGNAEIRRLTPPHHDRLAGFYNDDDKEAL Kraken2_NZ_CP121077.1 IMICODJL_32587 Prodigal:2.6 105024 114521 - VFG000362(gb|WP_002212777) 97.3 0.0 (irp1) yersiniabactin biosynthetic protein Irp1 VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MDNLRFSSAPTADSIDASIAQHYPDCEPVAVIGYACHFPESPDGETFWQNLLEGRECSRRFTREELLAVGLDAAIIDDPHYVNIGTVLDNADCFDATLFGYSRQEAESMDPQQRLFLQAVWHALEHAGYAPGAVPHKTGVFASSRMSTYPGREALNVTEVAQVKGLQSLMGNDKDYIATRAAYKLNLHGPALSVQTACSSSLVAVHLACESLRAGESDMAVAGGVALSFPQQAGYRYQPGMIFSPDGHCRPFDASAEGTWAGNGLGCVVLRRLRDALLSGDPIISVILSSAVNNDGNRKVGYTAPSVAGQQAVIEEALMLAAIDDRQVGYIETHGTGTPLGDAIEIEALRNVYAPRPQDERCALGSVKSNMGHLDTAAGIAGLLKTVLAVSRGQIPPLLNFHTPNPALKLEESPFTIPVSAQAWQDEMRYAGVSSFGIGGTNCHMIVASLPDALNARLPNTDGGRKSTALLLSAASDSALRRLATDYAGALRDNADASSLAFTALHARRLDLPFRLAAPLNRETAAALSAWAGEKSGELVYSGHGASGKQVWLFTGQGSHWRTMGQTMYRHSTAFADTLDRCFSACSEMLTPSLREAMFNPDSAQLDNMAWAQPAIVAFEIAMAAHWRAEGLKPDFAIGHSVGEFAAAVVCGHYTIEQVMPLVCRRGALMQQCASGAMVAVFADEDTLMPLARQFELDLAANNGTQHTVFSGPEARLAIFCATLSQHDIDYRRLSVTGAAHSALLEPILDRFQAACAGLHAEPGQIPIISTLTADVIDESTLNQADYWRRHMRQPVRFIQSIQMAHQLGARVFLEMGPDAQLVASGQREYRDNAYWIASARRNKEANDVLNQALLQLYAAGVALPWANLLAGDGQRIAAPCYPFDTERYWKERVSPACEPADAALSAGLEVASRAAAALDHPRLEALKQCATRLHAIYVDQLVQRCTGDAIENGVDAMTIMRRGRLLPRYQQLLQRLLNNCVVDGDYRCTDGRYARARPIEHQQRESLLTELAGYCEGFQAIPDTIARAGDRLYEMMSGAEEPVAIIFPQSASDGVEVLYQEFSFGRYFNQIAAGVLRGIVQTRQPRQPLRILEVGGGTGGTTAWLLPELSGVPALEYHFTDISALFTRRAQQKFADYDFVKYSELDLEKEAQSQGFLAQSYDLIVAANVIHATRHIGRTLDNLRPLLKPGGRLLMREITQPMRLFDFVFGPLVLPLQDLDAREGELFLTTAQWQQQCRHAGFSKVAWLPQDDSPTAGMSEHIILATLPGQAVSAVTFTAPSEPVLGQALTDNGDYLADWSDCAGQPEQFNARCQEAWRLLSQRHGDALPVEPPLAAAPEWLGEVRLSWQNEAFSRGQMRVEARHPDGKWLPLSPAAPLPAPQTHYQWRWTPLNIASADHPLTFNFSAGMLARRDELAQYGIIHDPHASSRLMIVEESEDTLALAEKVIAALTASAAGLIVVTRRAWRVEENEALSASHHALWALLRVAANEQPERLIAAIDLAENTPWETLHQGLSAVSLSQRWLAARGNTLWLPSLAPNTGCAAELPANVFTGDNRWHLVTGAFGGLGRLAVNWLREKGARRIALLAPRVDESWLRDVEGGQTRVCRCDVGDTGQMTTVLDDLAANGGIAGAIHAAGVLADAPLQELDDHQRAAVFAVKAQAANQLLQTLRNHDGRYLILYSSAAATLGAPGQSAHALACGYLDGLAQQFSTLDAPKTLSVAWGAWGESGRAATPEMLATLANRGMGALSDAEGCWHLEQAVMRGTPWRLAMRVFTDKMPPLQQALFNISATEKAATPVIPPADDNAFNGSLSDETAVMAWLKKRIAVQLRLSNPASLRPNQDLLQLGMDSLLFLELSSDIQHYLGVRINAERAWQDLSPHGLTQLICSKPETTPAASQPEVLRHDADERYAPFPLTPIQHAYWLGRTHLIGYGGVACHVLFEWDKRHDEFDLAILEKAWNQLIARHDMLRMVVDADGQQRVLATTPEYHIPRDDLRALSPEEQRIALEKRRHELSYRVLPADQWPLFELVVSKIDDCHYRLHMNLDLLQFDVQSFKVMMDDLAQVWRGETLAPLDITFRDYVMAEQARRQTSAWHDAWDYWQEKLPQLPLAPELPVVETPPETPHFTTFKSTIGKKEWQAVKQRWQQQGVTPSAALLTLFAATLERWSRTTAFTLNLTFFNRQPIHPQINQLIGDFTSVTLVDFNFSTPVTLQEQMQQTQQRLWQNMAHSEMNGVEVIRELGRLRGSQRQPLMPVVFTSMLGMTLEGMTIDQAMSHLFGEPCYVFTQTPQVWLDHQVMESDGELMFSWYCMDNVLEPGAAEAMFNDYCAILQAVIAAPESLKTLASGIAGHIPRRRWPLNAQTDYDLRDIEQATLEYPGIRQTRAEIAEQGALTLDIVMVDDPSPSAATPDEHDLAQLALALPLPAQVQLDELEATWRWLEARALQGIAATLNRHGLFTTPEIAHRFSAIVQALSAQASHQRLLRQWLQCLTEREWLIREGESWRCRVPLSEIPEPQEACPQSQWSQALAQYLETCIARHDALFSGQCSPLELLFNEQHRVTDALYRDNPASACLNRYIAQIAALCGAERILEVGAGTAATTAPVLQATRNTRQSYHFTDVSAQFLNDARARFHDESRVSYALFDINQPLDFTAHPEAGYDLIVAVNVLHDASHVVQTLRRLKLLLKAGGRLLIVEATERNSVFQLASVGFIEGLSGYRDFRRRDEKPMLTRSAWQEVLVQAGFTNELAWPTQESSPLRQHLLLARSPGVNRPNKEAVSRYLQQRFGTGLPVLQIRQRETLFTPQHAPSDALIEPPKPTPVAGGNPALEKQVAELWQSLLSRPVARHHDFFELGGDSLMATRMVAQLNRRGIARANLQDLFSHSTLSDFCAHLQAATSGEDNPVPLCQGDGEETLFVFHASDGDISAWLPLASALNRRVFGLQAKSPLRFATLDQMIDEYVGCIRRQQPHGPYVLAGWSYGAFLAAGAAQRLYAKGEQVRMVLIDPVCRQDFCCDNRAALLRLLAEEQTPLALPEHFDQQTPDSQLADFIGLAKTAGMVSQNLTLQAAETWLDNIAHLLRLLTEHTPGESVPVPCLMVYAAGRPARWTPAETEWQGWINNADGYVIEASHWQIMMEAPHVQACAQHITRWLCATSTQLENTL Kraken2_NZ_CP121077.1 IMICODJL_32588 Prodigal:2.6 114609 120716 - VFG000363(gb|WP_002212775) 97.7 0.0 (irp2) yersiniabactin biosynthetic protein Irp2 VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MISGAPSQDSLLPDNRHAADYQQLRERLIQELNLTPQQLHEESNLIQAGLDSIRLMRWLHWFRKNGYRLTLRELYAAPTLAAWNQLILSRSPENAEEETPPDESSWPNMTESTPFPLTPVQHAYLTGRMPGQTLGGVGCHLYQEFEGHCLTASQLEQAITALLQRHPMLHIAFRPDGQQIWLPQPYWNGVTVHDLRHNDAESRQPYLEALRQRLSHRLLRVEIGETFDFQLTLLPDNRHRLHVNIDLLIMDASSFTLFFDELNALLAGESLSAIDTRYDFRSYLLHQQKINQPLRDNARAYWLAKASTLPPAPVLPLTCEPATLREVRNTRRRMIVPATRWHAFSNRAGEYGVTPTMALATCFSAVLARWGGLTRLLLNITLFDRQPLHPSVGAMLADFTNILLLDTACDGDTVSNLARKNQLTFTEDWEHRHWSGVELLRELKRQQRYPHGAPVVFTSNLGRSLYSSRAESPLGEPEWGISQTPQVWIDHLAFEHHGEVWLQWDSNDALFPPALVETLFDAYCQLINQLCDDESAWQKPFADMMPARQRAIRERVNATGAPIPEGLLHEGIFRIALQQPQALAVTDMRYQWNYYELTDYARRCAGRLIECGVQPGDNVAITMSKGAGQLVAVLAVLLAGAVYVPVSLDQPAARREKIYADASVRLVLICQHDASAWSDDIPVLAWQQAIEAEPIANPVVRAPTQPAYIIYTSGSTGTPKGVVISHRGALNTCCDINTRYQVGPGDRVLALSALHFDLSVYDIFGVLRAGGVLVMVMENQRRDPHAWCELIQRHQVTLWNSVPALFDMLLTWCEGFADATPENLRAVMLSGDWIGLDLPARYRAFRPQGQFIAMGGATEASIWSNACEIHDVPAHWRSIPYGFPLTNQRYRVVDEWGRDCPDWVPGELWIGGIGVAEGYFNDPLRSEQQFLTHPDERWYRTGDLGCYWPDGTIEFLGRRDKQVKVGGYRIELGEIESALSQLAGVKQATVLAIGEKEKTLAAYVVPQGEAFCVTDHRDPALPQAWHTLAGTLPCCAISPEISAEQVADFLQHRLLKLKPGHTAGADPLPLMNSLAIQPRWQAVVERWLAFLVTQRRLKPAAEGYQVCAGEERKDEHPNFSGHDLTLSQILRGTRDELSLLNDAQWSPESLAFNHPASAPYIQELATICQQLAQSLQRPVRLLEVGTRTGRAAESLLVQLNAGQVEYVGLEQSQEMLLSARQRLVPRLGARLSPWNADTLAVHAHSADIIWLNNALHRLLPEDPGLLATLQQLAVPGALLYVMEFRQLTPSALLSTLLLTDGQPEALLHNSADWAALFSAAAFNCQHGDEVAGLQRFLVQCPDSQVRRDPRQLQAALAGRLPGWMVPQRIVFLDALPLTANGKIDYQALKRRHTPEAENQAEADLPQGDTEKQVAALWQQLLSTGNVTRETDFFQQGGDSLLATRLTGQLHQAGYEAQLSDLFNHPRLADFAATLRKIDVPVEQPFVHSPEDRYQPFALTDVQQAYLVGCQPGFALGGVGSHFFVEFEIADLDLTRLETVWNRLIARHDMLRAVVRDGQQQVLEQTPHWVIPAHTLHTPEEALRAREKLAHQVLNPEVWPVFDLQVGYVNGMPARLWLCLDNLLLDGLSMQILLAELEHGYRYPQQLPPPLPVTFRDYLQQPSLQSPNPDSLAWWQAQLDDIPPAPALPLRCLPQEVETPRFTRLNGALDSTRWHRLKKRAADAHLTPSAVLLSVWSTVLSAWSAQPEFTLNLTLFDRRPLHPQINQILGDFTSLMLLSWHPGESWLHSAQSLQQRLSQNLNHRDVSAIRVMRQLAQRQNVPAIPMPVVFTSALGFEQDNFLARRNLLKPVWGISQTPQVWLDHQVYESEGELRFNWDFVAALFPAGQVERQFEQYCALLNRMAEDESGWQLPLAALVPPVKFAGQCAERSPRVCPEHSQPHIAADESTVSLICDAFREVVGESVTPAENFFEAGATSLNLVQLHILLQRHEFSTLTLLDLFTHPSPAALADYLAGVVTVEKTKHPRPVRRRQRRI Kraken2_NZ_CP121077.1 IMICODJL_32589 Prodigal:2.6 120907 121866 - VFG034084(gb|WP_000140406) 98.4 9.33e-235 (ybtA) yersiniabactin transcriptional regulator YbtA VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MTESPQTQSEISIHQLVIGKPANDGNIPAQCELLRCSLQEGMDILLWRGHFARPETLQLHDDLGRINFSCILEGTSRFAIQGLRRHTDWELARNRHYITHTPDCRGSASYCGRFESITLSFSPETLALWVPDINAVIKNKIDSQCCCQQQRCNAETHLTAQTLRHALMRMHGGFSHEQKPSTLWLQGQSLVMLSLVLDEHREDASCLSCHFNPMERQKLLRAKDLLLADLTQAPGVAELARESGLSVLKIKRGFRVLFNNSVYGLFQAERMQEARRRLANGNTSVMTVAADLGYANASHFSTAFQKQFGVTPSTFKRVM Kraken2_NZ_CP121077.1 IMICODJL_32590 Prodigal:2.6 122234 124036 + VFG012539(gb|WP_001327262) 98.2 0.0 (ybtP) yersiniabactin ABC transporter ATP-binding/permease protein YbtP VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MSSQSSNTESLSRFPLWQVITPVRRKVILAMALAGLAALTSLGALLFLAWSLRDLRATPDAIPAWPLGGVIGCVVLTFVLRLQAFNTSHYAAFHLENILRSRLARKALQLPPGVLQQMGSGSVAKVMLDDVKSLHIFVADSTPLYARAIIMPLATIVILFWLDWRLAIATLGVLAFGSVVLVLARQRSEDMAQRYHKAREQVSAAVIEFVQAMPVVRTFDSGSTSFLRYQRALEEWGDVLKTWYHKAGFSARFSFSILNPLPTLVVLIWSGYGLLHYGSLDFTAWVAVLLLGSGMAEAVMPMMMLNNLVAQTRLSIQRIYQVLAMPELSLPLSDQQPKEASITFEQVSFHYPQARTGAALQEVSFHVPAGQIVALVGPSGAGKSTVARLLLRYADPDKGHIRIGGVDLRDMQTDTLMKQLSFVFQDNFLFADTIANNIRLGAPDTPLEAVIAAARVAQAHDFISVLPEGYNTRVGERGVFLSGGQRQRITIARAILQDRPILVLDEATAFADPENEAALIKALAAAMRGRTVIMVAHRLSMVTQADVILLFSDGQLREMGNHTQLLAQGGLYQRLWQHYQQAQHWVPGGTQEEVVENERQ Kraken2_NZ_CP121077.1 IMICODJL_32591 Prodigal:2.6 124023 125825 + VFG003507(gb|WP_005168689) 97.2 0.0 (ybtQ) yersiniabactin ABC transporter ATP-binding/permease protein YbtQ VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MKDNNPADNLAWRVIWRQLISSVGSQARMLRRSMLALLLAAFMQGVAFACLYPIIDALLRGDAPQLLNWAVAFSVATIVTLALRWYGLGFEYHGHLAQATHELRLRLGEQLRRVPLEKLQRGRAGEMNALLLGSVDENLNYVIAIANILLLTIITPLTASLATWWIDWRLGLVMLLIFPLLVPFYYWRRPAMRRQMQTLGEAHQRLSGDIVEFAQGMMVLRTCGSDADKSRALLAHFNALENLQTRTHRQGAGATMLIASVVELGLQVVVLSGIVWVVTGNLNLAFLIAAVAMIMRFAEPMAMFISYTSVVELIASALQRIEQFMAIAPLPVAAQNEMPERYDIRFDNVSYCYEEGDGHALNNVSLTFPAASMSALVGASGAGKTTVTKLLMRYADPQQGQISIGGVDIRRLTPEQLNSLISVVFQDVWLFDDTLLANIRIARPQATRQAVEEAARAAQCLEFISRLPQGWLTPLGEMGGQLSGGERQRISIARALLKNAPVVILDEPTAALDIESELAVQKAIDNLVHNRTVIIIAHRLSTIAGAGNILVMEEGQVVEQGTHAQLLSRHGRYQALWQAQMAARAWRDEGVSASGEWVHE Kraken2_NZ_CP121077.1 IMICODJL_32592 Prodigal:2.6 125818 127098 + VFG034033(gb|WP_001286280) 97.9 8.659999999999999e-285 (ybtX) yersiniabactin-associated zinc MFS transporter YbtX VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MSDVQSNVKPLTLTTGRVIFAIAGVYVTQSLVSALSMQSLPALVRAAGGSLALAGATTLFMLPWALKFIWAPWIERWRLPPGSPERRSRMLILRGQVALAAILTIAAAIGWFGREGGFPDTQIVALFVLFMVAGTVASTIDIASDGFCVDQLTRAGYGWGNSVQVGGSYLGMMCGGGVFLMLSAASGWPVAMLMMAVLIMALSLPLWRITEPTRTETIPHIPALGYALRRKQARLGLLLVLMLNSGMRFVLPLLAPLLLDHGLSMSALGALFSGGNIAAGIAGTLAGGLLMKYTSPGRALLMTYGVQGIALLAVVMTLMMVPGHLLLPILQCLVIVQSISLACALVCLYATLMSLSSPLQAGVDFTLFQCTDAAIAILAGVIGGVVAQHFGYATCFLFAGAFTLLAAWVAYIRLYSARELMTSAID Kraken2_NZ_CP121077.1 IMICODJL_32593 Prodigal:2.6 127126 128457 + VFG012529(gb|WP_000703040) 95.8 2.17e-305 (ybtS) yersiniabactin biosynthesis salicylate synthase YbtS VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MKISEFLHLALPEEQWLPTISGVLRQFAEEECYVYECQPCWYLGKGCQVRLHINADGTQATFIDDAGEQQWAVDSIADCARRFMAHPQVKGRRVYGQVGFNFAAHAREIAFNAGEWPLLTLTVPREELIFEKGNVTVYADSADGCRRLCEWVKEARTTTQNAPLAVDTALNGEMYKQQVARAVAEIRRGEYAKVIVSRAIPLPSRIDMPATLLYGRQANTPTRSFMFRQEGREALGFSPELVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIVELESICQAGSVVVEDLMSVRQRGSVQHLGSSVSGNLAENKDAWDAFTALFPSITASGIPKNAALNAIMQIETTPRELYSGAILLLDDTRFDAALVLRSVFQDSQRCWIQAGAGIIAQSTPERELMETREKLASIVPYLMAAKLKAGVME Kraken2_NZ_CP121067.1 IMICODJL_32711 Prodigal:2.6 38204 38524 + VFG042448(gb|AAA23663) 68.0 4.25e-36 (daaA) DaaA protein VF0212 Afa/Dr family VFC0001 Adherence Afa/Dr family including afimbrial adhesins AfaE-I, AfaE-III and Dr-II as well as the fimbrial Dr and F1845 adhesins Receptor is the DAF (decay-accelerating factor (CD55)), a cell-surface glycosylphosphatidylinositol-anchored protein that normally protect cells from damage by complement system. The third short consensus repeat (SCR-3) domain of DAF plays a pivotal role in binding adhesins; another receptor is the membrane-associated GPI-anchored protein, the carcinoembryonic antigen (CEA), which belongs to CEACAMs family; inducing a cytopathic effect characterized by the development of long cellular extensions that wrap around the adherent bacteria. (All members of the Dr family including UPEC elicit this effect); binding of Dr adhesins is accompanied by the activation of several signal transduction cascades, including activation of PI-3 kinase MSGQDSYLLLTRSFGKSLIPGEMPEIHFWLLVEVSPIHSEKVIQSLKDHLVLGYTRVEACERHHVSPGYFSGALKRLQRVNQTVSRLMPYYIPQGEFTGQTIPVIC Kraken2_NZ_CP121067.1 IMICODJL_32712 Prodigal:2.6 38569 39108 + VFG034595(gb|WP_000708866) 84.0 2.25e-100 (faeC) FaeC VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MKKIKIFYLLLLAGGGLSHASVQKILFSADVVASACHVVVDADGTGSSRLTFGTYRKSSAAPVSPRDFTVRLYETGATVQGCSAFLAGQIATLNFGNPGQLDGQGVVTRGAGDGIRIDVRAADTQADFRGRITQANHAVKYPVDFAARGQFRFHAQPVFPADVKAGEYSGALTFVVTYQ Kraken2_NZ_CP121067.1 IMICODJL_32713 Prodigal:2.6 39133 40737 + VFG042494(gb|CAA50786) 85.4 1.64e-319 (cshB) cshB porin (usher) VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MRLMRMSPEERGARRTALALATAVALGSGTASAGEKLDMSFIQGGAGINPEVWAALNGDYAPGRYLVDLSLNGKEAGKHILDVTPQDSEALCLSEAWLAKAGIYVSAEYFREGYDATRQCYVLAKAPAVKVDFDVATQSLSLAIPQKGLVKMPENVEWDYGTEAFRMNYNANANTGRNNSSAFGSADLNANIGRWVVSSSATASTGDGGNNDATINMFTATRAIRSLSADLAVGKTSTGDSLLGSTGTYGVSLSRNNSMKPGNLGYTPVFSGIANGPSRVTLTQNGRTLYSGMMPAGPFSVTDVPLYSSGDVTMTVTGDDGREQTQVFPLSVMAGQLSPGQHEFSVAAGIPDDDSDLEGGVFAASYGYGLDGLTLRTGGVFNQDWQGASAGAVLGLGYLGALSTDGAYATAKYRDGSRRGNKVQVAWSKQLELTNTGLRVSWSRQSAEYEDMSSFNPAETWLQQNQGRRTRDEWNAGISQPVGGLFSLSASGWQRSYYPASTTGSYRYADDNGKETGITGTLSTQIKSVSLNLG Kraken2_NZ_CP121067.1 IMICODJL_32715 Prodigal:2.6 41582 42373 + VFG034597(gb|WP_000044493) 88.7 1.07e-156 (faeE) fimbrial chaperone FaeE VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MTMKQTQKMRSFFRNRVTKALGMTLALMMASQSALASLAADQTRYIFRGDKDALTITVTNNDKERTFGGQAWVDNIVEKDTRPTFVVTPSFFKVKPQGQQTLRIIMASDHLPKDKESVYWLNLQDIPPALKGSGIAIALRTKLKLFYRPEALLKDRKGAEEGISLQVRPDGRTMLVNTTPYIYAIGSLLDANGKKVAVDNDTAQKLLMFMPGDEVQVKGNVVKVDSLNDYGELQTWTINQKKVAAPEAKTVPETKTAAGAGKK Kraken2_NZ_CP121067.1 IMICODJL_32716 Prodigal:2.6 42406 42900 + VFG034598(gb|WP_000753462) 71.0 5.82e-72 (faeF) fimbrial protein FaeF VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MMKKALMAVALFSALPVLAADYSEKTQYLGVVNGQVVGNSVVKVTRTPADPVLYRTESNGPLPETLVIRNAESRPASGNMVYITVKRTLGDGRDARLTLKTTLMVDGQRAALSASQRGEDVVITVPAATRQVELRSDAPAELEVPANYRGNVQVPVEVEGVSVS Kraken2_NZ_CP121067.1 IMICODJL_32718 Prodigal:2.6 44110 44901 + VFG034600(gb|WP_000704731) 77.1 2.21e-146 (faeH) fimbrial protein FaeH VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MKITHHYKSIISALAALALFYSAAPRAGILDGGEIQFHGLVTDEAPKWTWQVGSPDQTWAVDTADARNENGFLVFDLRSKGTLPFLEGHLYEVAERGGPGFTPFITFSSNGQPFSVTAGGSTTAQHFRASVPVRNPENGHVAGQLSFTLDQGMAVSAGHQEDGAVLPAGMSLVNGQSVSGVQAGTLPQWLKSRLPSLLMLNRGFGNGMSTADNGQVISQGVLADARVTQLAAAYASAVSDFELRLPAENTPAQWQAGLSVTVQ Kraken2_NZ_CP121067.1 IMICODJL_32719 Prodigal:2.6 44929 45693 + VFG043644(gb|AAA23586) 66.9 6.15e-125 (clpL) CS31A minor subunit VF1147 CS31A capsule-like antigen VFC0001 Adherence MKRMTILLLAASLLPSCVLAWNTPGEDFSGELKLGGPVTSTRNPWVWKVGEGNTQINTKAHSVLRSGEQVIPVPLPAMTVLLGKTILTTPAGREGLAPQVTYGNGTEGFALMWTAPGTASVTLPVTGEGNVRTGTFSFRLQTAGVLRHVRGDRAEYAGLYDDLQGNGLPAQGQVMPAEQTPGVLQTLFDSEGPAWLREMTVSSVTGLSRFSDAALRQVDGVYGAQTVADSGELRFKGEIPSRWHTSLAVSIEYR Kraken2_NZ_CP121067.1 IMICODJL_32777 Prodigal:2.6 99406 101427 - VFG012567(gb|WP_000784549) 97.6 0.0 (fyuA) siderophore yersiniabactin receptor FyuA VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MKMTRLYPLALGGLLLPAIANAQTSQQDESTLVVTASKQSSRSASANNVSFTVVSAPELSDAGVTASDKLPKVLPGLNIENSGNMLFSTISLRGVSSAQDFYNPAVTLYVDGVPQLSTNTIQALTDVQSVELLRGPQGTLYGKSAQGGIINIVTRQPDNTPRGYIEGGVSSRDSYRSKLNLSGPIQDGLLYGSVTLLRQVDDGDMINPATGSDDLGGTRASIGNVKLRLAPDDQPWEIGFAASRECTRATQDAYVGWNDIKGRKLSISDGLPDPYMRRCTDSQTLSGKYTTDDWVFNLISAWQQQHYSRTFPSGSLIVNMPQRWNQDVQELRAATLGDARTVDMVFGLYRQNTREQMQATYDMPTMRYLTSAGYTTAETLAAYSDLTWHLTDRFDIGGGVRFSHDKSSTQYHGSMRGNPFGDQGKSNDDQVLGQLSAGYMLTDDWRVYTRVAQGYKPSGYNIVPTAGLDAKPFVAEKSINYELGTRYETADVTLQAATFYTHTKDMQLYSGPVGMQTLSNAGKADATGVELEAKWRFAPGWSWDINGNVIRSEFTNDSELYHGNRVPFVPRYGAGSSVNGVIDTRYGALMPRLAVNLVGPHYFDGDNQLRQGTYATLDSSLGWQATERMNISVYVDNLFDRRYRTYGYMNGSSAVAQVNMGRTVGINTRIDFF Kraken2_NZ_CP121067.1 IMICODJL_32778 Prodigal:2.6 101558 103135 - VFG048593(gb|WP_014907267) 97.3 0.0 (ybtE) yersiniabactin biosynthesis salycil-AMP ligase YbtE VF0564 Ybt Yersiniabactin VFC0272 Nutritional/Metabolic factor Ybt is the most common virulence factor associated with human K. pneumoniae infections The phenolate siderophore Ybt contributes to evasion of the activity of lipocalin2 in the lung – a host factor which neutralizes enterobactin-based iron acquisition MNSSFESLIEQYPLPIAEQLRHWAARYASRIAVVDAKGSLTYSALDARVDELAAGLSSLGLRSGEHVIVQLPNDNAFVTLLFALLRLGVIPVLAMPSQRALDIDALVELAQPVAYVIHGENHAELARQMAHKHACLRHVLVAGETVSNDFTPLFSLHGEQQAWPQPDVSATALLLLSGGTTGTPKLIPRRHADYSYNFSASAELCGISQQSVYLAVLPVAHNFPLACPGILGTLACGGKVVLTDSASCDEVMPLIAREGVTHVALVPALAQLWVQAREWEDSDLSSLRVIQAGGARLDPALAEQAIATFDCTLQQVFGMAEGLLCFTRLDDPHTTILHSQGRPLSPLDEIRIVDQNENDVAPGETGQLLTRGPYTISGYYRAPAHNAQAFTTQGFYRTGDNVRLDEAGNLHVEGRIKEQINRAGEKIAAAEVESALMRLAEVQDCAVVAAPDTLLGERICAFIIAQQVPTDYQQLRQQLTRMGLSAWKIPDQIEFLAHWPLTAVGKIDKKRLTALAIDRYRHSAQ Kraken2_NZ_CP121067.1 IMICODJL_32779 Prodigal:2.6 103139 103942 - VFG034147(gb|WP_000194282) 98.1 4.4800000000000005e-200 (ybtT) yersiniabactin biosynthesis thioesterase YbtT VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MTQSAMCIPLWPARNGNTAHLVMCPFAGGSSSAFRHWQAEQLADCALSLVIWPGRDRLRHLEPLRSITQLAALLTNELEASVSPDTPLLLAGHSMGAQVAFETCRLLEQQGHAPQGLIISGCHAPHLHSERQLSHRDDADFIAELIDIGGCSPELRENQELMSLFLPLLRADFDATESYHYDSPDVCPPLRTPALLLCGSHDREASWQQVDAWRQWLSHVTGPVVIDGDHFYPIQQARSFFTQIVRHFPHAFSAMTALQKQPSTSER Kraken2_NZ_CP121067.1 IMICODJL_32780 Prodigal:2.6 103939 105039 - VFG034135(gb|WP_000982866) 98.1 5.55e-278 (ybtU) yersiniabactin biosynthesis oxidoreductase YbtU VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MMPSASPKQRVLIVGAKFGEMYLNAFMQPPEGLELVGLLAQGSARSRELAHAFGIPLYTSPEQITRMPDIACIVVRSTVAGGTGTQLARHFLARGVHVIQEHPLHPDDISSLQTLAQEQGCCYWVNTFYPHTRAGRTWLRDAQQLRRCLAKTPPVVHATTSRQLLYSTLDLLLLALGVDAVAVECDVVGSFGDFHCLRLFWPKGEACLLLQRYLDPDDPDMHSLIMHRLLLGWPEGHLSLEASYGPVIWSSSLFVADHQENAHSLYRRPEILRDPPGLTRSAAPLSWHDCCETVGPEGVSWLLHQLRSHLAGEHPPAACQSVHQIALSRLWQQILRQTGNAEIRRLTPPHHDRLAGFYNDDDKEAL Kraken2_NZ_CP121067.1 IMICODJL_32781 Prodigal:2.6 105036 114533 - VFG000362(gb|WP_002212777) 97.3 0.0 (irp1) yersiniabactin biosynthetic protein Irp1 VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MDNLRFSSAPTADSIDASIAQHYPDCEPVAVIGYACHFPESPDGETFWQNLLEGRECSRRFTREELLAVGLDAAIIDDPHYVNIGTVLDNADCFDATLFGYSRQEAESMDPQQRLFLQAVWHALEHAGYAPGAVPHKTGVFASSRMSTYPGREALNVTEVAQVKGLQSLMGNDKDYIATRAAYKLNLHGPALSVQTACSSSLVAVHLACESLRAGESDMAVAGGVALSFPQQAGYRYQPGMIFSPDGHCRPFDASAEGTWAGNGLGCVVLRRLRDALLSGDPIISVILSSAVNNDGNRKVGYTAPSVAGQQAVIEEALMLAAIDDRQVGYIETHGTGTPLGDAIEIEALRNVYAPRPQDERCALGSVKSNMGHLDTAAGIAGLLKTVLAVSRGQIPPLLNFHTPNPALKLEESPFTIPVSAQAWQDEMRYAGVSSFGIGGTNCHMIVASLPDALNARLPNTDGGRKSTALLLSAASDSALRRLATDYAGALRDNADASSLAFTALHARRLDLPFRLAAPLNRETAAALSAWAGEKSGELVYSGHGASGKQVWLFTGQGSHWRTMGQTMYRHSTAFADTLDRCFSACSEMLTPSLREAMFNPDSAQLDNMAWAQPAIVAFEIAMAAHWRAEGLKPDFAIGHSVGEFAAAVVCGHYTIEQVMPLVCRRGALMQQCASGAMVAVFADEDTLMPLARQFELDLAANNGTQHTVFSGPEARLAIFCATLSQHDIDYRRLSVTGAAHSALLEPILDRFQAACAGLHAEPGQIPIISTLTADVIDESTLNQADYWRRHMRQPVRFIQSIQMAHQLGARVFLEMGPDAQLVASGQREYRDNAYWIASARRNKEANDVLNQALLQLYAAGVALPWANLLAGDGQRIAAPCYPFDTERYWKERVSPACEPADAALSAGLEVASRAAAALDHPRLEALKQCATRLHAIYVDQLVQRCTGDAIENGVDAMTIMRRGRLLPRYQQLLQRLLNNCVVDGDYRCTDGRYARARPIEHQQRESLLTELAGYCEGFQAIPDTIARAGDRLYEMMSGAEEPVAIIFPQSASDGVEVLYQEFSFGRYFNQIAAGVLRGIVQTRQPRQPLRILEVGGGTGGTTAWLLPELSGVPALEYHFTDISALFTRRAQQKFADYDFVKYSELDLEKEAQSQGFLAQSYDLIVAANVIHATRHIGRTLDNLRPLLKPGGRLLMREITQPMRLFDFVFGPLVLPLQDLDAREGELFLTTAQWQQQCRHAGFSKVAWLPQDDSPTAGMSEHIILATLPGQAVSAVTFTAPSEPVLGQALTDNGDYLADWSDCAGQPEQFNARCQEAWRLLSQRHGDALPVEPPLAAAPEWLGEVRLSWQNEAFSRGQMRVEARHPDGKWLPLSPAAPLPAPQTHYQWRWTPLNIASADHPLTFNFSAGMLARRDELAQYGIIHDPHASSRLMIVEESEDTLALAEKVIAALTASAAGLIVVTRRAWRVEENEALSASHHALWALLRVAANEQPERLIAAIDLAENTPWETLHQGLSAVSLSQRWLAARGNTLWLPSLAPNTGCAAELPANVFTGDNRWHLVTGAFGGLGRLAVNWLREKGARRIALLAPRVDESWLRDVEGGQTRVCRCDVGDTGQMTTVLDDLAANGGIAGAIHAAGVLADAPLQELDDHQRAAVFAVKAQAANQLLQTLRNHDGRYLILYSSAAATLGAPGQSAHALACGYLDGLAQQFSTLDAPKTLSVAWGAWGESGRAATPEMLATLANRGMGALSDAEGCWHLEQAVMRGTPWRLAMRVFTDKMPPLQQALFNISATEKAATPVIPPADDNAFNGSLSDETAVMAWLKKRIAVQLRLSNPASLRPNQDLLQLGMDSLLFLELSSDIQHYLGVRINAERAWQDLSPHGLTQLICSKPETTPAASQPEVLRHDADERYAPFPLTPIQHAYWLGRTHLIGYGGVACHVLFEWDKRHDEFDLAILEKAWNQLIARHDMLRMVVDADGQQRVLATTPEYHIPRDDLRALSPEEQRIALEKRRHELSYRVLPADQWPLFELVVSKIDDCHYRLHMNLDLLQFDVQSFKVMMDDLAQVWRGETLAPLDITFRDYVMAEQARRQTSAWHDAWDYWQEKLPQLPLAPELPVVETPPETPHFTTFKSTIGKKEWQAVKQRWQQQGVTPSAALLTLFAATLERWSRTTAFTLNLTFFNRQPIHPQINQLIGDFTSVTLVDFNFSTPVTLQEQMQQTQQRLWQNMAHSEMNGVEVIRELGRLRGSQRQPLMPVVFTSMLGMTLEGMTIDQAMSHLFGEPCYVFTQTPQVWLDHQVMESDGELMFSWYCMDNVLEPGAAEAMFNDYCAILQAVIAAPESLKTLASGIAGHIPRRRWPLNAQTDYDLRDIEQATLEYPGIRQTRAEIAEQGALTLDIVMVDDPSPSAATPDEHDLAQLALALPLPAQVQLDELEATWRWLEARALQGIAATLNRHGLFTTPEIAHRFSAIVQALSAQASHQRLLRQWLQCLTEREWLIREGESWRCRVPLSEIPEPQEACPQSQWSQALAQYLETCIARHDALFSGQCSPLELLFNEQHRVTDALYRDNPASACLNRYIAQIAALCGAERILEVGAGTAATTAPVLQATRNTRQSYHFTDVSAQFLNDARARFHDESRVSYALFDINQPLDFTAHPEAGYDLIVAVNVLHDASHVVQTLRRLKLLLKAGGRLLIVEATERNSVFQLASVGFIEGLSGYRDFRRRDEKPMLTRSAWQEVLVQAGFTNELAWPTQESSPLRQHLLLARSPGVNRPNKEAVSRYLQQRFGTGLPVLQIRQRETLFTPQHAPSDALIEPPKPTPVAGGNPALEKQVAELWQSLLSRPVARHHDFFELGGDSLMATRMVAQLNRRGIARANLQDLFSHSTLSDFCAHLQAATSGEDNPVPLCQGDGEETLFVFHASDGDISAWLPLASALNRRVFGLQAKSPLRFATLDQMIDEYVGCIRRQQPHGPYVLAGWSYGAFLAAGAAQRLYAKGEQVRMVLIDPVCRQDFCCDNRAALLRLLAEEQTPLALPEHFDQQTPDSQLADFIGLAKTAGMVSQNLTLQAAETWLDNIAHLLRLLTEHTPGESVPVPCLMVYAAGRPARWTPAETEWQGWINNADGYVIEASHWQIMMEAPHVQACAQHITRWLCATSTQLENTL Kraken2_NZ_CP121067.1 IMICODJL_32782 Prodigal:2.6 114621 120728 - VFG000363(gb|WP_002212775) 97.7 0.0 (irp2) yersiniabactin biosynthetic protein Irp2 VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MISGAPSQDSLLPDNRHAADYQQLRERLIQELNLTPQQLHEESNLIQAGLDSIRLMRWLHWFRKNGYRLTLRELYAAPTLAAWNQLILSRSPENAEEETPPDESSWPNMTESTPFPLTPVQHAYLTGRMPGQTLGGVGCHLYQEFEGHCLTASQLEQAITALLQRHPMLHIAFRPDGQQIWLPQPYWNGVTVHDLRHNDAESRQPYLEALRQRLSHRLLRVEIGETFDFQLTLLPDNRHRLHVNIDLLIMDASSFTLFFDELNALLAGESLSAIDTRYDFRSYLLHQQKINQPLRDNARAYWLAKASTLPPAPVLPLTCEPATLREVRNTRRRMIVPATRWHAFSNRAGEYGVTPTMALATCFSAVLARWGGLTRLLLNITLFDRQPLHPSVGAMLADFTNILLLDTACDGDTVSNLARKNQLTFTEDWEHRHWSGVELLRELKRQQRYPHGAPVVFTSNLGRSLYSSRAESPLGEPEWGISQTPQVWIDHLAFEHHGEVWLQWDSNDALFPPALVETLFDAYCQLINQLCDDESAWQKPFADMMPARQRAIRERVNATGAPIPEGLLHEGIFRIALQQPQALAVTDMRYQWNYYELTDYARRCAGRLIECGVQPGDNVAITMSKGAGQLVAVLAVLLAGAVYVPVSLDQPAARREKIYADASVRLVLICQHDASAWSDDIPVLAWQQAIEAEPIANPVVRAPTQPAYIIYTSGSTGTPKGVVISHRGALNTCCDINTRYQVGPGDRVLALSALHFDLSVYDIFGVLRAGGVLVMVMENQRRDPHAWCELIQRHQVTLWNSVPALFDMLLTWCEGFADATPENLRAVMLSGDWIGLDLPARYRAFRPQGQFIAMGGATEASIWSNACEIHDVPAHWRSIPYGFPLTNQRYRVVDEWGRDCPDWVPGELWIGGIGVAEGYFNDPLRSEQQFLTHPDERWYRTGDLGCYWPDGTIEFLGRRDKQVKVGGYRIELGEIESALSQLAGVKQATVLAIGEKEKTLAAYVVPQGEAFCVTDHRDPALPQAWHTLAGTLPCCAISPEISAEQVADFLQHRLLKLKPGHTAGADPLPLMNSLAIQPRWQAVVERWLAFLVTQRRLKPAAEGYQVCAGEERKDEHPNFSGHDLTLSQILRGTRDELSLLNDAQWSPESLAFNHPASAPYIQELATICQQLAQSLQRPVRLLEVGTRTGRAAESLLVQLNAGQVEYVGLEQSQEMLLSARQRLVPRLGARLSPWNADTLAVHAHSADIIWLNNALHRLLPEDPGLLATLQQLAVPGALLYVMEFRQLTPSALLSTLLLTDGQPEALLHNSADWAALFSAAAFNCQHGDEVAGLQRFLVQCPDSQVRRDPRQLQAALAGRLPGWMVPQRIVFLDALPLTANGKIDYQALKRRHTPEAENQAEADLPQGDTEKQVAALWQQLLSTGNVTRETDFFQQGGDSLLATRLTGQLHQAGYEAQLSDLFNHPRLADFAATLRKIDVPVEQPFVHSPEDRYQPFALTDVQQAYLVGCQPGFALGGVGSHFFVEFEIADLDLTRLETVWNRLIARHDMLRAVVRDGQQQVLEQTPHWVIPAHTLHTPEEALRAREKLAHQVLNPEVWPVFDLQVGYVNGMPARLWLCLDNLLLDGLSMQILLAELEHGYRYPQQLPPPLPVTFRDYLQQPSLQSPNPDSLAWWQAQLDDIPPAPALPLRCLPQEVETPRFTRLNGALDSTRWHRLKKRAADAHLTPSAVLLSVWSTVLSAWSAQPEFTLNLTLFDRRPLHPQINQILGDFTSLMLLSWHPGESWLHSAQSLQQRLSQNLNHRDVSAIRVMRQLAQRQNVPAIPMPVVFTSALGFEQDNFLARRNLLKPVWGISQTPQVWLDHQVYESEGELRFNWDFVAALFPAGQVERQFEQYCALLNRMAEDESGWQLPLAALVPPVKFAGQCAERSPRVCPEHSQPHIAADESTVSLICDAFREVVGESVTPAENFFEAGATSLNLVQLHILLQRHEFSTLTLLDLFTHPSPAALADYLAGVVTVEKTKHPRPVRRRQRRI Kraken2_NZ_CP121067.1 IMICODJL_32783 Prodigal:2.6 120919 121878 - VFG034084(gb|WP_000140406) 98.4 9.33e-235 (ybtA) yersiniabactin transcriptional regulator YbtA VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MTESPQTQSEISIHQLVIGKPANDGNIPAQCELLRCSLQEGMDILLWRGHFARPETLQLHDDLGRINFSCILEGTSRFAIQGLRRHTDWELARNRHYITHTPDCRGSASYCGRFESITLSFSPETLALWVPDINAVIKNKIDSQCCCQQQRCNAETHLTAQTLRHALMRMHGGFSHEQKPSTLWLQGQSLVMLSLVLDEHREDASCLSCHFNPMERQKLLRAKDLLLADLTQAPGVAELARESGLSVLKIKRGFRVLFNNSVYGLFQAERMQEARRRLANGNTSVMTVAADLGYANASHFSTAFQKQFGVTPSTFKRVM Kraken2_NZ_CP121067.1 IMICODJL_32784 Prodigal:2.6 122246 124048 + VFG012539(gb|WP_001327262) 98.2 0.0 (ybtP) yersiniabactin ABC transporter ATP-binding/permease protein YbtP VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MSSQSSNTESLSRFPLWQVITPVRRKVILAMALAGLAALTSLGALLFLAWSLRDLRATPDAIPAWPLGGVIGCVVLTFVLRLQAFNTSHYAAFHLENILRSRLARKALQLPPGVLQQMGSGSVAKVMLDDVKSLHIFVADSTPLYARAIIMPLATIVILFWLDWRLAIATLGVLAFGSVVLVLARQRSEDMAQRYHKAREQVSAAVIEFVQAMPVVRTFDSGSTSFLRYQRALEEWGDVLKTWYHKAGFSARFSFSILNPLPTLVVLIWSGYGLLHYGSLDFTAWVAVLLLGSGMAEAVMPMMMLNNLVAQTRLSIQRIYQVLAMPELSLPLSDQQPKEASITFEQVSFHYPQARTGAALQEVSFHVPAGQIVALVGPSGAGKSTVARLLLRYADPDKGHIRIGGVDLRDMQTDTLMKQLSFVFQDNFLFADTIANNIRLGAPDTPLEAVIAAARVAQAHDFISVLPEGYNTRVGERGVFLSGGQRQRITIARAILQDRPILVLDEATAFADPENEAALIKALAAAMRGRTVIMVAHRLSMVTQADVILLFSDGQLREMGNHTQLLAQGGLYQRLWQHYQQAQHWVPGGTQEEVVENERQ Kraken2_NZ_CP121067.1 IMICODJL_32785 Prodigal:2.6 124035 125837 + VFG003507(gb|WP_005168689) 97.3 0.0 (ybtQ) yersiniabactin ABC transporter ATP-binding/permease protein YbtQ VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MKDNNPADNLAWRVIWRQLISSVGSQARMLRRSMLALLLAAFMQGVAFACLYPIIDALLRGDAPQLLNWAVAFSVATIVTLALRWYGLGFEYRGHLAQATHELRLRLGEQLRRVPLEKLQRGRAGEMNALLLGSVDENLNYVIAIANILLLTIITPLTASLATWWIDWRLGLVMLLIFPLLVPFYYWRRPAMRRQMQTLGEAHQRLSGDIVEFAQGMMVLRTCGSDADKSRALLAHFNALENLQTRTHRQGAGATMLIASVVELGLQVVVLSGIVWVVTGNLNLAFLIAAVAMIMRFAEPMAMFISYTSVVELIASALQRIEQFMAIAPLPVAAQNEMPERYDIRFDNVSYCYEEGDGHALNNVSLTFPAASMSALVGASGAGKTTVTKLLMRYADPQQGQISIGGVDIRRLTPEQLNSLISVVFQDVWLFDDTLLANIRIARPQATRQAVEEAARAAQCLEFISRLPQGWLTPLGEMGGQLSGGERQRISIARALLKNAPVVILDEPTAALDIESELAVQKAIDNLVHNRTVIIIAHRLSTIAGAGNILVMEEGQVVEQGTHAQLLSRHGRYQALWQAQMAARAWRDEGVSASGEWVHE Kraken2_NZ_CP121067.1 IMICODJL_32786 Prodigal:2.6 125830 127110 + VFG034033(gb|WP_001286280) 97.9 8.659999999999999e-285 (ybtX) yersiniabactin-associated zinc MFS transporter YbtX VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MSDVQSNVKPLTLTTGRVIFAIAGVYVTQSLVSALSMQSLPALVRAAGGSLALAGATTLFMLPWALKFIWAPWIERWRLPPGSPERRSRMLILRGQVALAAILTIAAAIGWFGREGGFPDTQIVALFVLFMVAGTVASTIDIASDGFCVDQLTRAGYGWGNSVQVGGSYLGMMCGGGVFLMLSAASGWPVAMLMMAVLIMALSLPLWRITEPTRTETIPHIPALGYALRRKQARLGLLLVLMLNSGMRFVLPLLAPLLLDHGLSMSALGALFSGGNIAAGIAGTLAGGLLMKYTSPGRALLMTYGVQGIALLAVVMTLMMVPGHLLLPILQCLVIVQSISLACALVCLYATLMSLSSPLQAGVDFTLFQCTDAAIAILAGVIGGVVAQHFGYATCFLFAGAFTLLAAWVAYIRLYSARELMTSAID Kraken2_NZ_CP121067.1 IMICODJL_32787 Prodigal:2.6 127138 128469 + VFG012529(gb|WP_000703040) 95.8 2.17e-305 (ybtS) yersiniabactin biosynthesis salicylate synthase YbtS VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MKISEFLHLALPEEQWLPTISGVLRQFAEEECYVYECQPCWYLGKGCQVRLHINADGTQATFIDDAGEQQWAVDSIADCARRFMAHPQVKGRRVYGQVGFNFAAHAREIAFNAGEWPLLTLTVPREELIFEKGNVTVYADSADGCRRLCEWVKEARTTTQNAPLAVDTALNGEMYKQQVARAVAEIRRGEYAKVIVSRAIPLPSRIDMPATLLYGRQANTPTRSFMFRQEGREALGFSPELVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIVELESICQAGSVVVEDLMSVRQRGSVQHLGSSVSGNLAENKDAWDAFTALFPSITASGIPKNAALNAIMQIETTPRELYSGAILLLDDTRFDAALVLRSVFQDSQRCWIQAGAGIIAQSTPERELMETREKLASIVPYLMAAKLKAGVME Kraken2_NZ_CP121071.1 IMICODJL_32905 Prodigal:2.6 38204 38524 + VFG042448(gb|AAA23663) 68.0 4.25e-36 (daaA) DaaA protein VF0212 Afa/Dr family VFC0001 Adherence Afa/Dr family including afimbrial adhesins AfaE-I, AfaE-III and Dr-II as well as the fimbrial Dr and F1845 adhesins Receptor is the DAF (decay-accelerating factor (CD55)), a cell-surface glycosylphosphatidylinositol-anchored protein that normally protect cells from damage by complement system. The third short consensus repeat (SCR-3) domain of DAF plays a pivotal role in binding adhesins; another receptor is the membrane-associated GPI-anchored protein, the carcinoembryonic antigen (CEA), which belongs to CEACAMs family; inducing a cytopathic effect characterized by the development of long cellular extensions that wrap around the adherent bacteria. (All members of the Dr family including UPEC elicit this effect); binding of Dr adhesins is accompanied by the activation of several signal transduction cascades, including activation of PI-3 kinase MSGQDSYLLLTRSFGKSLIPGEMPEIHFWLLVEVSPIHSEKVIQSLKDHLVLGYTRVEACERHHVSPGYFSGALKRLQRVNQTVSRLMPYYIPQGEFTGQTIPVIC Kraken2_NZ_CP121071.1 IMICODJL_32906 Prodigal:2.6 38569 39108 + VFG034595(gb|WP_000708866) 84.0 2.25e-100 (faeC) FaeC VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MKKIKIFYLLLLAGGGLSHASVQKILFSADVVASACHVVVDADGTGSSRLTFGTYRKSSAAPVSPRDFTVRLYETGATVQGCSAFLAGQIATLNFGNPGQLDGQGVVTRGAGDGIRIDVRAADTQADFRGRITQANHAVKYPVDFAARGQFRFHAQPVFPADVKAGEYSGALTFVVTYQ Kraken2_NZ_CP121071.1 IMICODJL_32907 Prodigal:2.6 39133 40737 + VFG042494(gb|CAA50786) 85.4 1.64e-319 (cshB) cshB porin (usher) VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MRLMRMSPEERGARRTALALATAVALGSGTASAGEKLDMSFIQGGAGINPEVWAALNGDYAPGRYLVDLSLNGKEAGKHILDVTPQDSEALCLSEAWLAKAGIYVSAEYFREGYDATRQCYVLAKAPAVKVDFDVATQSLSLAIPQKGLVKMPENVEWDYGTEAFRMNYNANANTGRNNSSAFGSADLNANIGRWVVSSSATASTGDGGNNDATINMFTATRAIRSLSADLAVGKTSTGDSLLGSTGTYGVSLSRNNSMKPGNLGYTPVFSGIANGPSRVTLTQNGRTLYSGMMPAGPFSVTDVPLYSSGDVTMTVTGDDGREQTQVFPLSVMAGQLSPGQHEFSVAAGIPDDDSDLEGGVFAASYGYGLDGLTLRTGGVFNQDWQGASAGAVLGLGYLGALSTDGAYATAKYRDGSRRGNKVQVAWSKQLELTNTGLRVSWSRQSAEYEDMSSFNPAETWLQQNQGRRTRDEWNAGISQPVGGLFSLSASGWQRSYYPASTTGSYRYADDNGKETGITGTLSTQIKSVSLNLG Kraken2_NZ_CP121071.1 IMICODJL_32909 Prodigal:2.6 41582 42373 + VFG034597(gb|WP_000044493) 88.7 1.07e-156 (faeE) fimbrial chaperone FaeE VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MTMKQTQKMRSFFRNRVTKALGMTLALMMASQSALASLAADQTRYIFRGDKDALTITVTNNDKERTFGGQAWVDNIVEKDTRPTFVVTPSFFKVKPQGQQTLRIIMASDHLPKDKESVYWLNLQDIPPALKGSGIAIALRTKLKLFYRPEALLKDRKGAEEGISLQVRPDGRTMLVNTTPYIYAIGSLLDANGKKVAVDNDTAQKLLMFMPGDEVQVKGNVVKVDSLNDYGELQTWTINQKKVAAPEAKTVPETKTAAGAGKK Kraken2_NZ_CP121071.1 IMICODJL_32910 Prodigal:2.6 42406 42900 + VFG034598(gb|WP_000753462) 71.0 5.82e-72 (faeF) fimbrial protein FaeF VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MMKKALMAVALFSALPVLAADYSEKTQYLGVVNGQVVGNSVVKVTRTPADPVLYRTESNGPLPETLVIRNAESRPASGNMVYITVKRTLGDGRDARLTLKTTLMVDGQRAALSASQRGEDVVITVPAATRQVELRSDAPAELEVPANYRGNVQVPVEVEGVSVS Kraken2_NZ_CP121071.1 IMICODJL_32912 Prodigal:2.6 44110 44901 + VFG034600(gb|WP_000704731) 77.1 2.21e-146 (faeH) fimbrial protein FaeH VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MKITHHYKSIISALAALALFYSAAPRAGILDGGEIQFHGLVTDEAPKWTWQVGSPDQTWAVDTADARNENGFLVFDLRSKGTLPFLEGHLYEVAERGGPGFTPFITFSSNGQPFSVTAGGSTTAQHFRASVPVRNPENGHVAGQLSFTLDQGMAVSAGHQEDGAVLPAGMSLVNGQSVSGVQAGTLPQWLKSRLPSLLMLNRGFGNGMSTADNGQVISQGVLADARVTQLAAAYASAVSDFELRLPAENTPAQWQAGLSVTVQ Kraken2_NZ_CP121071.1 IMICODJL_32913 Prodigal:2.6 44929 45693 + VFG043644(gb|AAA23586) 66.9 6.15e-125 (clpL) CS31A minor subunit VF1147 CS31A capsule-like antigen VFC0001 Adherence MKRMTILLLAASLLPSCVLAWNTPGEDFSGELKLGGPVTSTRNPWVWKVGEGNTQINTKAHSVLRSGEQVIPVPLPAMTVLLGKTILTTPAGREGLAPQVTYGNGTEGFALMWTAPGTASVTLPVTGEGNVRTGTFSFRLQTAGVLRHVRGDRAEYAGLYDDLQGNGLPAQGQVMPAEQTPGVLQTLFDSEGPAWLREMTVSSVTGLSRFSDAALRQVDGVYGAQTVADSGELRFKGEIPSRWHTSLAVSIEYR Kraken2_NZ_CP121071.1 IMICODJL_32971 Prodigal:2.6 99382 101403 - VFG012567(gb|WP_000784549) 97.6 0.0 (fyuA) siderophore yersiniabactin receptor FyuA VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MKMTRLYPLALGGLLLPAIANAQTSQQDESTLVVTASKQSSRSASANNVSFTVVSAPELSDAGVTASDKLPKVLPGLNIENSGNMLFSTISLRGVSSAQDFYNPAVTLYVDGVPQLSTNTIQALTDVQSVELLRGPQGTLYGKSAQGGIINIVTRQPDNTPRGYIEGGVSSRDSYRSKLNLSGPIQDGLLYGSVTLLRQVDDGDMINPATGSDDLGGTRASIGNVKLRLAPDDQPWEIGFAASRECTRATQDAYVGWNDIKGRKLSISDGLPDPYMRRCTDSQTLSGKYTTDDWVFNLISAWQQQHYSRTFPSGSLIVNMPQRWNQDVQELRAATLGDARTVDMVFGLYRQNTREQMQATYDMPTMRYLTSAGYTTAETLAAYSDLTWHLTDRFDIGGGVRFSHDKSSTQYHGSMRGNPFGDQGKSNDDQVLGQLSAGYMLTDDWRVYTRVAQGYKPSGYNIVPTAGLDAKPFVAEKSINYELGTRYETADVTLQAATFYTHTKDMQLYSGPVGMQTLSNAGKADATGVELEAKWRFAPGWSWDINGNVIRSEFTNDSELYHGNRVPFVPRYGAGSSVNGVIDTRYGALMPRLAVNLVGPHYFDGDNQLRQGTYATLDSSLGWQATERMNISVYVDNLFDRRYRTYGYMNGSSAVAQVNMGRTVGINTRIDFF Kraken2_NZ_CP121071.1 IMICODJL_32972 Prodigal:2.6 101534 103111 - VFG048593(gb|WP_014907267) 97.3 0.0 (ybtE) yersiniabactin biosynthesis salycil-AMP ligase YbtE VF0564 Ybt Yersiniabactin VFC0272 Nutritional/Metabolic factor Ybt is the most common virulence factor associated with human K. pneumoniae infections The phenolate siderophore Ybt contributes to evasion of the activity of lipocalin2 in the lung – a host factor which neutralizes enterobactin-based iron acquisition MNSSFESLIEQYPLPIAEQLRHWAARYASRIAVVDAKGSLTYSALDARVDELAAGLSSLGLRSGEHVIVQLPNDNAFVTLLFALLRLGVIPVLAMPSQRALDIDALVELAQPVAYVIHGENHAELARQMAHKHACLRHVLVAGETVSNDFTPLFSLHGEQQAWPQPDVSATALLLLSGGTTGTPKLIPRRHADYSYNFSASAELCGISQQSVYLAVLPVAHNFPLACPGILGTLACGGKVVLTDSASCDEVMPLIAREGVTHVALVPALAQLWVQAREWEDSDLSSLRVIQAGGARLDPALAEQAIATFDCTLQQVFGMAEGLLCFTRLDDPHTTILHSQGRPLSPLDEIRIVDQNENDVAPGETGQLLTRGPYTISGYYRAPAHNAQAFTTQGFYRTGDNVRLDEAGNLHVEGRIKEQINRAGEKIAAAEVESALMRLAEVQDCAVVAAPDTLLGERICAFIIAQQVPTDYQQLRQQLTRMGLSAWKIPDQIEFLAHWPLTAVGKIDKKRLTALAIDRYRHSAQ Kraken2_NZ_CP121071.1 IMICODJL_32973 Prodigal:2.6 103115 103918 - VFG034147(gb|WP_000194282) 98.1 4.4800000000000005e-200 (ybtT) yersiniabactin biosynthesis thioesterase YbtT VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MTQSAMCIPLWPARNGNTAHLVMCPFAGGSSSAFRHWQAEQLADCALSLVIWPGRDRLRHLEPLRSITQLAALLTNELEASVSPDTPLLLAGHSMGAQVAFETCRLLEQQGHAPQGLIISGCHAPHLHSERQLSHRDDADFIAELIDIGGCSPELRENQELMSLFLPLLRADFDATESYHYDSPDVCPPLRTPALLLCGSHDREASWQQVDAWRQWLSHVTGPVVIDGDHFYPIQQARSFFTQIVRHFPHAFSAMTALQKQPSTSER Kraken2_NZ_CP121071.1 IMICODJL_32974 Prodigal:2.6 103915 105015 - VFG034135(gb|WP_000982866) 98.1 5.55e-278 (ybtU) yersiniabactin biosynthesis oxidoreductase YbtU VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MMPSASPKQRVLIVGAKFGEMYLNAFMQPPEGLELVGLLAQGSARSRELAHAFGIPLYTSPEQITRMPDIACIVVRSTVAGGTGTQLARHFLARGVHVIQEHPLHPDDISSLQTLAQEQGCCYWVNTFYPHTRAGRTWLRDAQQLRRCLAKTPPVVHATTSRQLLYSTLDLLLLALGVDAVAVECDVVGSFGDFHCLRLFWPKGEACLLLQRYLDPDDPDMHSLIMHRLLLGWPEGHLSLEASYGPVIWSSSLFVADHQENAHSLYRRPEILRDPPGLTRSAAPLSWHDCCETVGPEGVSWLLHQLRSHLAGEHPPAACQSVHQIALSRLWQQILRQTGNAEIRRLTPPHHDRLAGFYNDDDKEAL Kraken2_NZ_CP121071.1 IMICODJL_32975 Prodigal:2.6 105012 114509 - VFG000362(gb|WP_002212777) 97.3 0.0 (irp1) yersiniabactin biosynthetic protein Irp1 VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MDNLRFSSAPTADSIDASIAQHYPDCEPVAVIGYACHFPESPDGETFWQNLLEGRECSRRFTREELLAVGLDAAIIDDPHYVNIGTVLDNADCFDATLFGYSRQEAESMDPQQRLFLQAVWHALEHAGYAPGAVPHKTGVFASSRMSTYPGREALNVTEVAQVKGLQSLMGNDKDYIATRAAYKLNLHGPALSVQTACSSSLVAVHLACESLRAGESDMAVAGGVALSFPQQAGYRYQPGMIFSPDGHCRPFDASAEGTWAGNGLGCVVLRRLRDALLSGDPIISVILSSAVNNDGNRKVGYTAPSVAGQQAVIEEALMLAAIDDRQVGYIETHGTGTPLGDAIEIEALRNVYAPRPQDERCALGSVKSNMGHLDTAAGIAGLLKTVLAVSRGQIPPLLNFHTPNPALKLEESPFTIPVSAQAWQDEMRYAGVSSFGIGGTNCHMIVASLPDALNARLPNTDGGRKSTALLLSAASDSALRRLATDYAGALRDNADASSLAFTALHARRLDLPFRLAAPLNRETAAALSAWAGEKSGELVYSGHGASGKQVWLFTGQGSHWRTMGQTMYRHSTAFADTLDRCFSACSEMLTPSLREAMFNPDSAQLDNMAWAQPAIVAFEIAMAAHWRAEGLKPDFAIGHSVGEFAAAVVCGHYTIEQVMPLVCRRGALMQQCASGAMVAVFADEDTLMPLARQFELDLAANNGTQHTVFSGPEARLAIFCATLSQHDIDYRRLSVTGAAHSALLEPILDRFQAACAGLHAEPGQIPIISTLTADVIDESTLNQADYWRRHMRQPVRFIQSIQMAHQLGARVFLEMGPDAQLVASGQREYRDNAYWIASARRNKEANDVLNQALLQLYAAGVALPWANLLAGDGQRIAAPCYPFDTERYWKERVSPACEPADAALSAGLEVASRAAAALDHPRLEALKQCATRLHAIYVDQLVQRCTGDAIENGVDAMTIMRRGRLLPRYQQLLQRLLNNCVVDGDYRCTDGRYARARPIEHQQRESLLTELAGYCEGFQAIPDTIARAGDRLYEMMSGAEEPVAIIFPQSASDGVEVLYQEFSFGRYFNQIAAGVLRGIVQTRQPRQPLRILEVGGGTGGTTAWLLPELSGVPALEYHFTDISALFTRRAQQKFADYDFVKYSELDLEKEAQSQGFLAQSYDLIVAANVIHATRHIGRTLDNLRPLLKPGGRLLMREITQPMRLFDFVFGPLVLPLQDLDAREGELFLTTAQWQQQCRHAGFSKVAWLPQDDSPTAGMSEHIILATLPGQAVSAVTFTAPSEPVLGQALTDNGDYLADWSDCAGQPEQFNARCQEAWRLLSQRHGDALPVEPPLAAAPEWLGEVRLSWQNEAFSRGQMRVEARHPDGKWLPLSPAAPLPAPQTHYQWRWTPLNIASADHPLTFNFSAGMLARRDELAQYGIIHDPHASSRLMIVEESEDTLALAEKVIAALTASAAGLIVVTRRAWRVEENEALSASHHALWALLRVAANEQPERLIAAIDLAENTPWETLHQGLSAVSLSQRWLAARGNTLWLPSLAPNTGCAAELPANVFTGDNRWHLVTGAFGGLGRLAVNWLREKGARRIALLAPRVDESWLRDVEGGQTRVCRCDVGDTGQMTTVLDDLAANGGIAGAIHAAGVLADAPLQELDDHQRAAVFAVKAQAANQLLQTLRNHDGRYLILYSSAAATLGAPGQSAHALACGYLDGLAQQFSTLDAPKTLSVAWGAWGESGRAATPEMLATLANRGMGALSDAEGCWHLEQAVMRGTPWRLAMRVFTDKMPPLQQALFNISATEKAATPVIPPADDNAFNGSLSDETAVMAWLKKRIAVQLRLSNPASLRPNQDLLQLGMDSLLFLELSSDIQHYLGVRINAERAWQDLSPHGLTQLICSKPETTPAASQPEVLRHDADERYAPFPLTPIQHAYWLGRTHLIGYGGVACHVLFEWDKRHDEFDLAILEKAWNQLIARHDMLRMVVDADGQQRVLATTPEYHIPRDDLRALSPEEQRIALEKRRHELSYRVLPADQWPLFELVVSKIDDCHYRLHMNLDLLQFDVQSFKVMMDDLAQVWRGETLAPLDITFRDYVMAEQARRQTSAWHDAWDYWQEKLPQLPLAPELPVVETPPETPHFTTFKSTIGKKEWQAVKQRWQQQGVTPSAALLTLFAATLERWSRTTAFTLNLTFFNRQPIHPQINQLIGDFTSVTLVDFNFSTPVTLQEQMQQTQQRLWQNMAHSEMNGVEVIRELGRLRGSQRQPLMPVVFTSMLGMTLEGMTIDQAMSHLFGEPCYVFTQTPQVWLDHQVMESDGELMFSWYCMDNVLEPGAAEAMFNDYCAILQAVIAAPESLKTLASGIAGHIPRRRWPLNAQTDYDLRDIEQATLEYPGIRQTRAEIAEQGALTLDIVMVDDPSPSAATPDEHDLAQLALALPLPAQVQLDELEATWRWLEARALQGIAATLNRHGLFTTPEIAHRFSAIVQALSAQASHQRLLRQWLQCLTEREWLIREGESWRCRVPLSEIPEPQEACPQSQWSQALAQYLETCIARHDALFSGQCSPLELLFNEQHRVTDALYRDNPASACLNRYIAQIAALCGAERILEVGAGTAATTAPVLQATRNTRQSYHFTDVSAQFLNDARARFHDESRVSYALFDINQPLDFTAHPEAGYDLIVAVNVLHDASHVVQTLRRLKLLLKAGGRLLIVEATERNSVFQLASVGFIEGLSGYRDFRRRDEKPMLTRSAWQEVLVQAGFTNELAWPTQESSPLRQHLLLARSPGVNRPNKEAVSRYLQQRFGTGLPVLQIRQRETLFTPQHAPSDALIEPPKPTPVAGGNPALEKQVAELWQSLLSRPVARHHDFFELGGDSLMATRMVAQLNRRGIARANLQDLFSHSTLSDFCAHLQAATSGEDNPVPLCQGDGEETLFVFHASDGDISAWLPLASALNRRVFGLQAKSPLRFATLDQMIDEYVGCIRRQQPHGPYVLAGWSYGAFLAAGAAQRLYAKGEQVRMVLIDPVCRQDFCCDNRAALLRLLAEEQTPLALPEHFDQQTPDSQLADFIGLAKTAGMVSQNLTLQAAETWLDNIAHLLRLLTEHTPGESVPVPCLMVYAAGRPARWTPAETEWQGWINNADGYVIEASHWQIMMEAPHVQACAQHITRWLCATSTQLENTL Kraken2_NZ_CP121071.1 IMICODJL_32976 Prodigal:2.6 114597 120704 - VFG000363(gb|WP_002212775) 97.7 0.0 (irp2) yersiniabactin biosynthetic protein Irp2 VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MISGAPSQDSLLPDNRHAADYQQLRERLIQELNLTPQQLHEESNLIQAGLDSIRLMRWLHWFRKNGYRLTLRELYAAPTLAAWNQLILSRSPENAEEETPPDESSWPNMTESTPFPLTPVQHAYLTGRMPGQTLGGVGCHLYQEFEGHCLTASQLEQAITALLQRHPMLHIAFRPDGQQIWLPQPYWNGVTVHDLRHNDAESRQPYLEALRQRLSHRLLRVEIGETFDFQLTLLPDNRHRLHVNIDLLIMDASSFTLFFDELNALLAGESLSAIDTRYDFRSYLLHQQKINQPLRDNARAYWLAKASTLPPAPVLPLTCEPATLREVRNTRRRMIVPATRWHAFSNRAGEYGVTPTMALATCFSAVLARWGGLTRLLLNITLFDRQPLHPSVGAMLADFTNILLLDTACDGDTVSNLARKNQLTFTEDWEHRHWSGVELLRELKRQQRYPHGAPVVFTSNLGRSLYSSRAESPLGEPEWGISQTPQVWIDHLAFEHHGEVWLQWDSNDALFPPALVETLFDAYCQLINQLCDDESAWQKPFADMMPARQRAIRERVNATGAPIPEGLLHEGIFRIALQQPQALAVTDMRYQWNYYELTDYARRCAGRLIECGVQPGDNVAITMSKGAGQLVAVLAVLLAGAVYVPVSLDQPAARREKIYADASVRLVLICQHDASAWSDDIPVLAWQQAIEAEPIANPVVRAPTQPAYIIYTSGSTGTPKGVVISHRGALNTCCDINTRYQVGPGDRVLALSALHFDLSVYDIFGVLRAGGVLVMVMENQRRDPHAWCELIQRHQVTLWNSVPALFDMLLTWCEGFADATPENLRAVMLSGDWIGLDLPARYRAFRPQGQFIAMGGATEASIWSNACEIHDVPAHWRSIPYGFPLTNQRYRVVDEWGRDCPDWVPGELWIGGIGVAEGYFNDPLRSEQQFLTHPDERWYRTGDLGCYWPDGTIEFLGRRDKQVKVGGYRIELGEIESALSQLAGVKQATVLAIGEKEKTLAAYVVPQGEAFCVTDHRDPALPQAWHTLAGTLPCCAISPEISAEQVADFLQHRLLKLKPGHTAGADPLPLMNSLAIQPRWQAVVERWLAFLVTQRRLKPAAEGYQVCAGEERKDEHPNFSGHDLTLSQILRGTRDELSLLNDAQWSPESLAFNHPASAPYIQELATICQQLAQSLQRPVRLLEVGTRTGRAAESLLVQLNAGQVEYVGLEQSQEMLLSARQRLVPRLGARLSPWNADTLAVHAHSADIIWLNNALHRLLPEDPGLLATLQQLAVPGALLYVMEFRQLTPSALLSTLLLTDGQPEALLHNSADWAALFSAAAFNCQHGDEVAGLQRFLVQCPDSQVRRDPRQLQAALAGRLPGWMVPQRIVFLDALPLTANGKIDYQALKRRHTPEAENQAEADLPQGDTEKQVAALWQQLLSTGNVTRETDFFQQGGDSLLATRLTGQLHQAGYEAQLSDLFNHPRLADFAATLRKIDVPVEQPFVHSPEDRYQPFALTDVQQAYLVGCQPGFALGGVGSHFFVEFEIADLDLTRLETVWNRLIARHDMLRAVVRDGQQQVLEQTPHWVIPAHTLHTPEEALRAREKLAHQVLNPEVWPVFDLQVGYVNGMPARLWLCLDNLLLDGLSMQILLAELEHGYRYPQQLPPPLPVTFRDYLQQPSLQSPNPDSLAWWQAQLDDIPPAPALPLRCLPQEVETPRFTRLNGALDSTRWHRLKKRAADAHLTPSAVLLSVWSTVLSAWSAQPEFTLNLTLFDRRPLHPQINQILGDFTSLMLLSWHPGESWLHSAQSLQQRLSQNLNHRDVSAIRVMRQLAQRQNVPAIPMPVVFTSALGFEQDNFLARRNLLKPVWGISQTPQVWLDHQVYESEGELRFNWDFVAALFPAGQVERQFEQYCALLNRMAEDESGWQLPLAALVPPVKFAGQCAERSPRVCPEHSQPHIAADESTVSLICDAFREVVGESVTPAENFFEAGATSLNLVQLHILLQRHEFSTLTLLDLFTHPSPAALADYLAGVVTVEKTKHPRPVRRRQRRI Kraken2_NZ_CP121071.1 IMICODJL_32977 Prodigal:2.6 120895 121854 - VFG034084(gb|WP_000140406) 98.4 9.33e-235 (ybtA) yersiniabactin transcriptional regulator YbtA VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MTESPQTQSEISIHQLVIGKPANDGNIPAQCELLRCSLQEGMDILLWRGHFARPETLQLHDDLGRINFSCILEGTSRFAIQGLRRHTDWELARNRHYITHTPDCRGSASYCGRFESITLSFSPETLALWVPDINAVIKNKIDSQCCCQQQRCNAETHLTAQTLRHALMRMHGGFSHEQKPSTLWLQGQSLVMLSLVLDEHREDASCLSCHFNPMERQKLLRAKDLLLADLTQAPGVAELARESGLSVLKIKRGFRVLFNNSVYGLFQAERMQEARRRLANGNTSVMTVAADLGYANASHFSTAFQKQFGVTPSTFKRVM Kraken2_NZ_CP121071.1 IMICODJL_32978 Prodigal:2.6 122222 124024 + VFG012539(gb|WP_001327262) 98.2 0.0 (ybtP) yersiniabactin ABC transporter ATP-binding/permease protein YbtP VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MSSQSSNTESLSRFPLWQVITPVRRKVILAMALAGLAALTSLGALLFLAWSLRDLRATPDAIPAWPLGGVIGCVVLTFVLRLQAFNTSHYAAFHLENILRSRLARKALQLPPGVLQQMGSGSVAKVMLDDVKSLHIFVADSTPLYARAIIMPLATIVILFWLDWRLAIATLGVLAFGSVVLVLARQRSEDMAQRYHKAREQVSAAVIEFVQAMPVVRTFDSGSTSFLRYQRALEEWGDVLKTWYHKAGFSARFSFSILNPLPTLVVLIWSGYGLLHYGSLDFTAWVAVLLLGSGMAEAVMPMMMLNNLVAQTRLSIQRIYQVLAMPELSLPLSDQQPKEASITFEQVSFHYPQARTGAALQEVSFHVPAGQIVALVGPSGAGKSTVARLLLRYADPDKGHIRIGGVDLRDMQTDTLMKQLSFVFQDNFLFADTIANNIRLGAPDTPLEAVIAAARVAQAHDFISVLPEGYNTRVGERGVFLSGGQRQRITIARAILQDRPILVLDEATAFADPENEAALIKALAAAMRGRTVIMVAHRLSMVTQADVILLFSDGQLREMGNHTQLLAQGGLYQRLWQHYQQAQHWVPGGTQEEVVENERQ Kraken2_NZ_CP121071.1 IMICODJL_32979 Prodigal:2.6 124011 125813 + VFG003507(gb|WP_005168689) 97.3 0.0 (ybtQ) yersiniabactin ABC transporter ATP-binding/permease protein YbtQ VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MKDNNPADNLAWRVIWRQLISSVGSQARMLRRSMLALLLAAFMQGVAFACLYPIIDALLRGDAPQLLNWAVAFSVATIVTLALRWYGLGFEYRGHLAQATHELRLRLGEQLRRVPLEKLQRGRAGEMNALLLGSVDENLNYVIAIANILLLTIITPLTASLATWWIDWRLGLVMLLIFPLLVPFYYWRRPAMRRQMQTLGEAHQRLSGDIVEFAQGMMVLRTCGSDADKSRALLAHFNALENLQTRTHRQGAGATMLIASVVELGLQVVVLSGIVWVVTGNLNLAFLIAAVAMIMRFAEPMAMFISYTSVVELIASALQRIEQFMAIAPLPVAAQNEMPERYDIRFDNVSYCYEEGDGHALNNVSLTFPAASMSALVGASGAGKTTVTKLLMRYADPQQGQISIGGVDIRRLTPEQLNSLISVVFQDVWLFDDTLLANIRIARPQATRQAVEEAARAAQCLEFISRLPQGWLTPLGEMGGQLSGGERQRISIARALLKNAPVVILDEPTAALDIESELAVQKAIDNLVHNRTVIIIAHRLSTIAGAGNILVMEEGQVVEQGTHAQLLSRHGRYQALWQAQMAARAWRDEGVSASGEWVHE Kraken2_NZ_CP121071.1 IMICODJL_32980 Prodigal:2.6 125806 127086 + VFG034033(gb|WP_001286280) 97.9 8.659999999999999e-285 (ybtX) yersiniabactin-associated zinc MFS transporter YbtX VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MSDVQSNVKPLTLTTGRVIFAIAGVYVTQSLVSALSMQSLPALVRAAGGSLALAGATTLFMLPWALKFIWAPWIERWRLPPGSPERRSRMLILRGQVALAAILTIAAAIGWFGREGGFPDTQIVALFVLFMVAGTVASTIDIASDGFCVDQLTRAGYGWGNSVQVGGSYLGMMCGGGVFLMLSAASGWPVAMLMMAVLIMALSLPLWRITEPTRTETIPHIPALGYALRRKQARLGLLLVLMLNSGMRFVLPLLAPLLLDHGLSMSALGALFSGGNIAAGIAGTLAGGLLMKYTSPGRALLMTYGVQGIALLAVVMTLMMVPGHLLLPILQCLVIVQSISLACALVCLYATLMSLSSPLQAGVDFTLFQCTDAAIAILAGVIGGVVAQHFGYATCFLFAGAFTLLAAWVAYIRLYSARELMTSAID Kraken2_NZ_CP121071.1 IMICODJL_32981 Prodigal:2.6 127114 128445 + VFG012529(gb|WP_000703040) 95.8 2.17e-305 (ybtS) yersiniabactin biosynthesis salicylate synthase YbtS VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MKISEFLHLALPEEQWLPTISGVLRQFAEEECYVYECQPCWYLGKGCQVRLHINADGTQATFIDDAGEQQWAVDSIADCARRFMAHPQVKGRRVYGQVGFNFAAHAREIAFNAGEWPLLTLTVPREELIFEKGNVTVYADSADGCRRLCEWVKEARTTTQNAPLAVDTALNGEMYKQQVARAVAEIRRGEYAKVIVSRAIPLPSRIDMPATLLYGRQANTPTRSFMFRQEGREALGFSPELVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIVELESICQAGSVVVEDLMSVRQRGSVQHLGSSVSGNLAENKDAWDAFTALFPSITASGIPKNAALNAIMQIETTPRELYSGAILLLDDTRFDAALVLRSVFQDSQRCWIQAGAGIIAQSTPERELMETREKLASIVPYLMAAKLKAGVME Kraken2_NZ_CP121004.1 IMICODJL_33065 Prodigal:2.6 5307 6047 + VFG002301(gb|NP_490536) 100.0 2.74e-170 (mig-5) putative carbonic anhydrase VF0396 Mig-5 Macrophage-inducible gene-5 VFC0325 Antimicrobial activity/Competitive advantage Mig-5 was found to be expressed by Salmonella when ingested by macrophages. mig-5 codes for the carbonic anhydrase which catalyses the hydratation of carbon dioxide and formation of HCO3-. The biological meaning of this reaction in intracellularilly residing of Salmonella is, however, not known. MEQNQPAQPSRRAILKQTLAVSALSVTGLAALSVPTISFAASLSKEERDGMTPDAVIEHFKQGNLRFRENRPAKHDYLAQKRNSIAGQYPAAVILSCIDSRAPAEIVLDAGIGETFNSRVAGNISNRDMLGSMEFACAVAGAKVVLVIGHTRCGAVRCAIDNAELGNLTGLLDEIKPAIAKTEYSGERKGSNYDFVDAVARKNVELTIENIRKNSPVLKQLEDEKKIKIVGSMYHLTGGKVEFFEV Kraken2_NZ_CP121004.1 IMICODJL_33075 Prodigal:2.6 13608 15383 + VFG000439(gb|NP_490529) 100.0 0.0 (spvB) type III secretion system effector SpvB, ADP-ribosylation activity VF0107 SpvB VFC0235 Exotoxin PDB accession: 2GWL SpvB-mediated actin depolymerization is associated with an accumulation of cells in the G2/M phase, eventually resulting in apoptotic cell death An ADP-ribosylating toxin that modifies actin directly and totally disrupt the cytoskeleton of the cell MLILNGFSSATLALITPPFLPKGGKALSQSGPDGLASITLPLPISAERGFAPALALHYSSGGGNGPFGVGWSCATMSIARRTSHGVPQYNDSDEFLGPDGEVLVQTLSTGDAPNPVTCFAYGDVSFPQSYTVTRYQPRTESSFYRLEYWVGNSNGDDFWLLHDSNGILHLLGKTAAARLSDPQAASHTAQWLVEESVTPAGEHIYYSYLAENGDNVDLNGNEAGRDRSAMRYLSKVQYGNATPAADLYLWTSATPAVQWLFTLVFDYGERGVDPQVPPAFTAQNSWLARQDPFSLYNYGFEIRLHRLCRQVLMFHHFPDELGEADTLVSRLLLEYDENPILTQLCAARTLAYEGDGYRRAPVNNMMPPPPPPPMMGGNSSRPKSKWAIVEESKQIQALRYYSAQGYSVINKYLRGDDYPETQAKETLLSRDYLSTNEPSDEEFKNAMSVYINDIAEGLSSLPETDHRVVYRGLKLDKPALSDVLKEYTTIGNIIIDKAFMSTSPDKAWINDTILNIYLEKGHKGRILGDVAHFKGEAEMLFPPNTKLKIESIVNCGSQDFASQLSKLRLSDDATADTNRIKRIINMRVLNS Kraken2_NZ_CP121004.1 IMICODJL_33076 Prodigal:2.6 15664 16389 + VFG000438(gb|NP_490528) 100.0 2.2e-178 (spvC) type III secretion system effector SpvC, phosphothreonine lyase VF0947 TTSS-2 secreted effectors VFC0086 Effector delivery system GogB; PipB; PipB2 (Directly binds kinesin, a plus end-directed microtubule motor protein. Localizes to the phagosome; Promotes Sif extension, recuits kinesin-1 to SCV. ); SifA (GEF. Localizes to the cytosolic face of the SCV and binds to host protein-kinesin-binding protein SKIP to modulate phagosome tubulation; required for SCV membrane integrity and Sif formation; maintains perinuclear SCV positioning; redirects exocytic vesicles to SCV. ); SifB (GEF, WxxxE family. ); SopD2 (Inhibits vesicle transport from the vacuole; down-modulates the formation of tubular structures. ); SpiC/ssaB (SsaL/ssaM/spiC regulatory complex, sensing host cell signals to activate effector secretion. ); SpvB (ADP-ribosyltransferase. Causes cytoskeletal disruption and apoptosis. ); SpvC; SpvD; SseF (Localizes to the phagosome, contributes to Sif formation; recruits dynein to SCV; maintains perinuclear SCV positioning; required for formation of microtubule bundles around SCV; redirects exocytic transport vesicles to SCV. ); SseG (Same as SseF. ); SseI/srfH (Blocks the migration of host immune cells by associating with host protein IQGAP1, an important regulator of cell migration; attenuates the host's ability to clear systemic bacteria. ); SseJ (Glycerophospholipid-cholesterol acyl transferase and deacylase. SseJ and SifA interact in a protein complex with SKIP and RhoA family GTPases as a mechanism to promote phagosome tubulation. ); SseK1; SseK2; SseL (Deubiquitinase. Required for Salmonella-induced delayed cytotoxicity of macrophages. ); SspH2 (Novel E3 ubiquitin-ligase. Specifically localizes to the brush border of polorized epithelial cells. ); SteC (Serine/Threonine kinase. Required for SPI-2 dependent F-actin remodelling. ) MPINRPNLNLNIPPLNIVAAYDGAEIPSTNKHLKNNFNSLHNQMRKMPVSHFKEALDVPDYSGMRQSGFFAMSQGFQLNNHGYDVFIHARRESPQSQGKFAGDKFHISVLRDMVPQAFQALSGLLFSEDSPVDKWKVTDMEKVVQQARVSLGAQFTLYIKPDQENSQYSASFLHKTRQFIECLESRLSENGVISGQCPESDVHPENWKYLSYRNELRSGRDGGEMQRQALREEPFYRLMTE Kraken2_NZ_CP121004.1 IMICODJL_33077 Prodigal:2.6 16651 17301 + VFG021746(gb|WP_015899538) 99.5 1.61e-154 (spvD) SPI-2 type III secretion system effector cysteine hydrolase SpvD VF0947 TTSS-2 secreted effectors VFC0086 Effector delivery system GogB; PipB; PipB2 (Directly binds kinesin, a plus end-directed microtubule motor protein. Localizes to the phagosome; Promotes Sif extension, recuits kinesin-1 to SCV. ); SifA (GEF. Localizes to the cytosolic face of the SCV and binds to host protein-kinesin-binding protein SKIP to modulate phagosome tubulation; required for SCV membrane integrity and Sif formation; maintains perinuclear SCV positioning; redirects exocytic vesicles to SCV. ); SifB (GEF, WxxxE family. ); SopD2 (Inhibits vesicle transport from the vacuole; down-modulates the formation of tubular structures. ); SpiC/ssaB (SsaL/ssaM/spiC regulatory complex, sensing host cell signals to activate effector secretion. ); SpvB (ADP-ribosyltransferase. Causes cytoskeletal disruption and apoptosis. ); SpvC; SpvD; SseF (Localizes to the phagosome, contributes to Sif formation; recruits dynein to SCV; maintains perinuclear SCV positioning; required for formation of microtubule bundles around SCV; redirects exocytic transport vesicles to SCV. ); SseG (Same as SseF. ); SseI/srfH (Blocks the migration of host immune cells by associating with host protein IQGAP1, an important regulator of cell migration; attenuates the host's ability to clear systemic bacteria. ); SseJ (Glycerophospholipid-cholesterol acyl transferase and deacylase. SseJ and SifA interact in a protein complex with SKIP and RhoA family GTPases as a mechanism to promote phagosome tubulation. ); SseK1; SseK2; SseL (Deubiquitinase. Required for Salmonella-induced delayed cytotoxicity of macrophages. ); SspH2 (Novel E3 ubiquitin-ligase. Specifically localizes to the brush border of polorized epithelial cells. ); SteC (Serine/Threonine kinase. Required for SPI-2 dependent F-actin remodelling. ) MRVSGSASSQDIISRINSKNINNNDSNEVKRIKDALCIESKERILYPQNLSRDNLKQMARYVNNTYVHYSGNCVLLSACLHYNIHHRQDILSSKNTASPTVGLDSAIVDKIIFGHELNQSYCLNSIDEVEKEILNRYDIKRESSFIISAENYIVPIIGECGHDFNAVVICEYDKKPYVQFIDSWKTSNILPSLQEIKKHFSSSGEFYVRAYDEKHD Kraken2_NZ_CP121004.1 IMICODJL_33094 Prodigal:2.6 28566 28868 + VFG000436(gb|NP_490511) 100.0 1.7499999999999999e-68 (pefB) plasmid-encoded fimbriae regulatory protein PefB VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MMLNRKDADYYLGKEIMLARIRRGALIPAKVNEEHFWLLIGISSIHSEKIIQALRDYLVFGVSRKDVCERYEVNNGYFSTSLNRLSRISQAAAQMVVYYS Kraken2_NZ_CP121004.1 IMICODJL_33095 Prodigal:2.6 29143 29667 + VFG000435(gb|NP_490510) 81.6 6.95e-87 (pefA) plasmid-encoded fimbriae major subunit PefA VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MKKSIIASIIALGVLGGTAHAANEVTFLGSVSATTCDLTTSVNGAAQPNQVVQLGTVQAGQEGTAVDFAMKPANPGSLGCQGLDTKTVTVSWASAALNADGFGATGGAATDATVLVNNVNAKTNPGAAVNANASTVEFNGADLNTDGLKFQAKLKGGQTEGDFKSVASFAVAYK Kraken2_NZ_CP121004.1 IMICODJL_33096 Prodigal:2.6 29894 32302 + VFG004409(gb|WP_001541550) 99.1 0.0 (pefC) plasmid-encoded fimbriae usher protein PefC VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MSFHHRVFKLSALSLALFSHLSFASTDSELNLDFLQGMGAIPSVLKSGSDFPAGQYYVDVIVNQENVGKARLSITPQEESANALCLSPEWLKAAGVPVRLEGYASTLDAAKQCYVLSRNPYTKVDFSYGSQSLVFSIPQSFLVSKTDPSRWDYGVPAARLKYSANASQTSGQSTSAYANADLMVNLGRWVLASNMSASRYADGSGEFTARDITLSTAISQVQGDLLLGKSQTRSALFSDFGFYGAALRSNSNMLPWEARGYAPLITGVANSTSRVTISQNGYTVYSKVVPPGPYQLDDVRSVGNGDLVVTVEDASGHKTTTVYPVTTLPTLLRPGEIEYNVAAGRKSSNYQLKKPFRDGESGTFWMGSVGYGFDSTTLNAASILHGKYQAGGVSVTQALGGFGAVSAGMNLSQAKYDNGDNKRGHSVSAKYAKSFSDSSDLQLLAYRYQSKGYVEFADFYSTDRYTRYNTKSRYEMRLSQRLGNSNLNLAGWQEDYWWMKGKATGGDVSLSTTILDGVSVFLNGSYSKRPYLDKPDYSTSLSFSIPFTLGGVRHYSSTGLSYSSSGRMGMNSGVSASPTDRLSYGLNTNLSDKGDRSLNGNLSYGFDAIQTNMMLSQGRDNTTVSGSVSGTILGTADSGLMMTKETGNTLGVARIPGVKGVRINGSAPTNSKGYTVVNLSDYSLNRVSVDMENVPDDLELQTTSFNVVPTEKAVVYREFGAEHVLRYILRVKERDGRILNGGSAQTEQGLDAGFIAGNGVLLMNMLSAPSRVSVERGDGSVCHFSVKGIVPNTGKVQEVYCE Kraken2_NZ_CP121004.1 IMICODJL_33097 Prodigal:2.6 32295 32987 + VFG004407(gb|WP_001038509) 100.0 8.61e-166 (pefD) plasmid-encoded fimbriae chaperone protein PefD VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MNKMMKWGLVSLLSLAVSGQAMAAFVLNGTRFIYEEGRKNTSFEVTNQADETFGGQVWIDNTTQGSSTVYMVPAPPFFKVRPKEKQIIRIMKTDSALPSDRESLFWLNVQEIPPKPKASEGNVLAVAVNTKVKLIYRPKALVEGRRNAEKNLQITHRGGEAYLKNPTPYYFAVTGVKLNGQPVRLNDRVMNEIAQLAPKSEVALGKLSLNGTVTVQAVNDWGGTQDYTLK Kraken2_NZ_CP121004.1 IMICODJL_33106 Prodigal:2.6 37428 37985 + VFG000442(gb|NP_490501) 98.4 1.21e-127 (rck) resistance to complement killing VF0108 Rck Resistance to complement killing VFC0258 Immune modulation Rck belongs to a family of five homologous OMP proteins characterized in Salmonella (Rck and PagC), Escherichia coli (Lom), Yersinia enterocolitica (Ail) and Enterobacter cloacae (OmpX) Rck is predicted to be an eight-stranded beta-barrel protein that resides in the outer membrane Confers serum resistance by binding human complement factor H.; Rck mediates cell invasion through a Zipper-like mechanism, as described for other bacteria such as Listeria and Yersinia. Salmonella seems to be the first bacterium found to be able to induce both Zipper-like mechanism and the Trigger mechanism mediated by its T3SS-1 apparatus. MKKIVLSSLLLSAAGLATVPVAQADTHSVSVGYAQSRIEHFKDIRGVNLKYRYEAQTPLGLMASFSWQSGKRGESGGIPGGMSWRDDVKATYWSLMAGPAVRVNELVSLYVLAGAGTGRAEVKEHISMPGYNGRFTGSERRTGFAWGAGVQFNPVENVVIDLGYEGSKVGAAKLNGVNVGVGYRF Kraken2_NZ_CP121004.1 IMICODJL_33124 Prodigal:2.6 48564 48935 - VFG001445(gb|AAA92657) 66.0 3.75e-38 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MENISFDNNEIIVLWQINLFPDHPFFSPDTKSKNLSISGNESFWNELSPGTLLVFSFYTLGVSHANIAKELGITIRASEDRIKPVKRKIKRNYESFDSFRISCISKGKIMSLIDIIREFYCVK Kraken2_NZ_CP121004.1 IMICODJL_33125 Prodigal:2.6 48938 49249 - VFG001445(gb|AAA92657) 64.0 3.46e-38 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MCPTDRRERTLASQSVNKYILSIQEIYKNSPVPVCVRNQSRKILYANGAFIELFSKEDQPLSGESYNRYQVEVFCHPWNLNVSRLDMELLFAGVLIFMGKFIR Kraken2_NZ_CP121074.1 IMICODJL_33672 Prodigal:2.6 38204 38524 + VFG042448(gb|AAA23663) 68.0 4.25e-36 (daaA) DaaA protein VF0212 Afa/Dr family VFC0001 Adherence Afa/Dr family including afimbrial adhesins AfaE-I, AfaE-III and Dr-II as well as the fimbrial Dr and F1845 adhesins Receptor is the DAF (decay-accelerating factor (CD55)), a cell-surface glycosylphosphatidylinositol-anchored protein that normally protect cells from damage by complement system. The third short consensus repeat (SCR-3) domain of DAF plays a pivotal role in binding adhesins; another receptor is the membrane-associated GPI-anchored protein, the carcinoembryonic antigen (CEA), which belongs to CEACAMs family; inducing a cytopathic effect characterized by the development of long cellular extensions that wrap around the adherent bacteria. (All members of the Dr family including UPEC elicit this effect); binding of Dr adhesins is accompanied by the activation of several signal transduction cascades, including activation of PI-3 kinase MSGQDSYLLLTRSFGKSLIPGEMPEIHFWLLVEVSPIHSEKVIQSLKDHLVLGYTRVEACERHHVSPGYFSGALKRLQRVNQTVSRLMPYYIPQGEFTGQTIPVIC Kraken2_NZ_CP121074.1 IMICODJL_33673 Prodigal:2.6 38569 39108 + VFG034595(gb|WP_000708866) 84.0 2.25e-100 (faeC) FaeC VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MKKIKIFYLLLLAGGGLSHASVQKILFSADVVASACHVVVDADGTGSSRLTFGTYRKSSAAPVSPRDFTVRLYETGATVQGCSAFLAGQIATLNFGNPGQLDGQGVVTRGAGDGIRIDVRAADTQADFRGRITQANHAVKYPVDFAARGQFRFHAQPVFPADVKAGEYSGALTFVVTYQ Kraken2_NZ_CP121074.1 IMICODJL_33674 Prodigal:2.6 39133 40737 + VFG042494(gb|CAA50786) 85.4 1.64e-319 (cshB) cshB porin (usher) VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MRLMRMSPEERGARRTALALATAVALGSGTASAGEKLDMSFIQGGAGINPEVWAALNGDYAPGRYLVDLSLNGKEAGKHILDVTPQDSEALCLSEAWLAKAGIYVSAEYFREGYDATRQCYVLAKAPAVKVDFDVATQSLSLAIPQKGLVKMPENVEWDYGTEAFRMNYNANANTGRNNSSAFGSADLNANIGRWVVSSSATASTGDGGNNDATINMFTATRAIRSLSADLAVGKTSTGDSLLGSTGTYGVSLSRNNSMKPGNLGYTPVFSGIANGPSRVTLTQNGRTLYSGMMPAGPFSVTDVPLYSSGDVTMTVTGDDGREQTQVFPLSVMAGQLSPGQHEFSVAAGIPDDDSDLEGGVFAASYGYGLDGLTLRTGGVFNQDWQGASAGAVLGLGYLGALSTDGAYATAKYRDGSRRGNKVQVAWSKQLELTNTGLRVSWSRQSAEYEDMSSFNPAETWLQQNQGRRTRDEWNAGISQPVGGLFSLSASGWQRSYYPASTTGSYRYADDNGKETGITGTLSTQIKSVSLNLG Kraken2_NZ_CP121074.1 IMICODJL_33676 Prodigal:2.6 41582 42373 + VFG034597(gb|WP_000044493) 88.7 1.07e-156 (faeE) fimbrial chaperone FaeE VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MTMKQTQKMRSFFRNRVTKALGMTLALMMASQSALASLAADQTRYIFRGDKDALTITVTNNDKERTFGGQAWVDNIVEKDTRPTFVVTPSFFKVKPQGQQTLRIIMASDHLPKDKESVYWLNLQDIPPALKGSGIAIALRTKLKLFYRPEALLKDRKGAEEGISLQVRPDGRTMLVNTTPYIYAIGSLLDANGKKVAVDNDTAQKLLMFMPGDEVQVKGNVVKVDSLNDYGELQTWTINQKKVAAPEAKTVPETKTAAGAGKK Kraken2_NZ_CP121074.1 IMICODJL_33677 Prodigal:2.6 42406 42900 + VFG034598(gb|WP_000753462) 71.0 5.82e-72 (faeF) fimbrial protein FaeF VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MMKKALMAVALFSALPVLAADYSEKTQYLGVVNGQVVGNSVVKVTRTPADPVLYRTESNGPLPETLVIRNAESRPASGNMVYITVKRTLGDGRDARLTLKTTLMVDGQRAALSASQRGEDVVITVPAATRQVELRSDAPAELEVPANYRGNVQVPVEVEGVSVS Kraken2_NZ_CP121074.1 IMICODJL_33679 Prodigal:2.6 44110 44901 + VFG034600(gb|WP_000704731) 77.1 2.21e-146 (faeH) fimbrial protein FaeH VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MKITHHYKSIISALAALALFYSAAPRAGILDGGEIQFHGLVTDEAPKWTWQVGSPDQTWAVDTADARNENGFLVFDLRSKGTLPFLEGHLYEVAERGGPGFTPFITFSSNGQPFSVTAGGSTTAQHFRASVPVRNPENGHVAGQLSFTLDQGMAVSAGHQEDGAVLPAGMSLVNGQSVSGVQAGTLPQWLKSRLPSLLMLNRGFGNGMSTADNGQVISQGVLADARVTQLAAAYASAVSDFELRLPAENTPAQWQAGLSVTVQ Kraken2_NZ_CP121074.1 IMICODJL_33680 Prodigal:2.6 44929 45693 + VFG043644(gb|AAA23586) 66.9 6.15e-125 (clpL) CS31A minor subunit VF1147 CS31A capsule-like antigen VFC0001 Adherence MKRMTILLLAASLLPSCVLAWNTPGEDFSGELKLGGPVTSTRNPWVWKVGEGNTQINTKAHSVLRSGEQVIPVPLPAMTVLLGKTILTTPAGREGLAPQVTYGNGTEGFALMWTAPGTASVTLPVTGEGNVRTGTFSFRLQTAGVLRHVRGDRAEYAGLYDDLQGNGLPAQGQVMPAEQTPGVLQTLFDSEGPAWLREMTVSSVTGLSRFSDAALRQVDGVYGAQTVADSGELRFKGEIPSRWHTSLAVSIEYR Kraken2_NZ_CP121074.1 IMICODJL_33738 Prodigal:2.6 99346 101367 - VFG012567(gb|WP_000784549) 97.6 0.0 (fyuA) siderophore yersiniabactin receptor FyuA VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MKMTRLYPLALGGLLLPAIANAQTSQQDESTLVVTASKQSSRSASANNVSFTVVSAPELSDAGVTASDKLPKVLPGLNIENSGNMLFSTISLRGVSSAQDFYNPAVTLYVDGVPQLSTNTIQALTDVQSVELLRGPQGTLYGKSAQGGIINIVTRQPDNTPRGYIEGGVSSRDSYRSKLNLSGPIQDGLLYGSVTLLRQVDDGDMINPATGSDDLGGTRASIGNVKLRLAPDDQPWEIGFAASRECTRATQDAYVGWNDIKGRKLSISDGLPDPYMRRCTDSQTLSGKYTTDDWVFNLISAWQQQHYSRTFPSGSLIVNMPQRWNQDVQELRAATLGDARTVDMVFGLYRQNTREQMQATYDMPTMRYLTSAGYTTAETLAAYSDLTWHLTDRFDIGGGVRFSHDKSSTQYHGSMRGNPFGDQGKSNDDQVLGQLSAGYMLTDDWRVYTRVAQGYKPSGYNIVPTAGLDAKPFVAEKSINYELGTRYETADVTLQAATFYTHTKDMQLYSGPVGMQTLSNAGKADATGVELEAKWRFAPGWSWDINGNVIRSEFTNDSELYHGNRVPFVPRYGAGSSVNGVIDTRYGALMPRLAVNLVGPHYFDGDNQLRQGTYATLDSSLGWQATERMNISVYVDNLFDRRYRTYGYMNGSSAVAQVNMGRTVGINTRIDFF Kraken2_NZ_CP121074.1 IMICODJL_33739 Prodigal:2.6 101498 103075 - VFG048593(gb|WP_014907267) 97.3 0.0 (ybtE) yersiniabactin biosynthesis salycil-AMP ligase YbtE VF0564 Ybt Yersiniabactin VFC0272 Nutritional/Metabolic factor Ybt is the most common virulence factor associated with human K. pneumoniae infections The phenolate siderophore Ybt contributes to evasion of the activity of lipocalin2 in the lung – a host factor which neutralizes enterobactin-based iron acquisition MNSSFESLIEQYPLPIAEQLRHWAARYASRIAVVDAKGSLTYSALDARVDELAAGLSSLGLRSGEHVIVQLPNDNAFVTLLFALLRLGVIPVLAMPSQRALDIDALVELAQPVAYVIHGENHAELARQMAHKHACLRHVLVAGETVSNDFTPLFSLHGEQQAWPQPDVSATALLLLSGGTTGTPKLIPRRHADYSYNFSASAELCGISQQSVYLAVLPVAHNFPLACPGILGTLACGGKVVLTDSASCDEVMPLIAREGVTHVALVPALAQLWVQAREWEDSDLSSLRVIQAGGARLDPALAEQAIATFDCTLQQVFGMAEGLLCFTRLDDPHTTILHSQGRPLSPLDEIRIVDQNENDVAPGETGQLLTRGPYTISGYYRAPAHNAQAFTTQGFYRTGDNVRLDEAGNLHVEGRIKEQINRAGEKIAAAEVESALMRLAEVQDCAVVAAPDTLLGERICAFIIAQQVPTDYQQLRQQLTRMGLSAWKIPDQIEFLAHWPLTAVGKIDKKRLTALAIDRYRHSAQ Kraken2_NZ_CP121074.1 IMICODJL_33740 Prodigal:2.6 103079 103882 - VFG034147(gb|WP_000194282) 98.1 4.4800000000000005e-200 (ybtT) yersiniabactin biosynthesis thioesterase YbtT VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MTQSAMCIPLWPARNGNTAHLVMCPFAGGSSSAFRHWQAEQLADCALSLVIWPGRDRLRHLEPLRSITQLAALLTNELEASVSPDTPLLLAGHSMGAQVAFETCRLLEQQGHAPQGLIISGCHAPHLHSERQLSHRDDADFIAELIDIGGCSPELRENQELMSLFLPLLRADFDATESYHYDSPDVCPPLRTPALLLCGSHDREASWQQVDAWRQWLSHVTGPVVIDGDHFYPIQQARSFFTQIVRHFPHAFSAMTALQKQPSTSER Kraken2_NZ_CP121074.1 IMICODJL_33741 Prodigal:2.6 103879 104979 - VFG034135(gb|WP_000982866) 98.1 5.55e-278 (ybtU) yersiniabactin biosynthesis oxidoreductase YbtU VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MMPSASPKQRVLIVGAKFGEMYLNAFMQPPEGLELVGLLAQGSARSRELAHAFGIPLYTSPEQITRMPDIACIVVRSTVAGGTGTQLARHFLARGVHVIQEHPLHPDDISSLQTLAQEQGCCYWVNTFYPHTRAGRTWLRDAQQLRRCLAKTPPVVHATTSRQLLYSTLDLLLLALGVDAVAVECDVVGSFGDFHCLRLFWPKGEACLLLQRYLDPDDPDMHSLIMHRLLLGWPEGHLSLEASYGPVIWSSSLFVADHQENAHSLYRRPEILRDPPGLTRSAAPLSWHDCCETVGPEGVSWLLHQLRSHLAGEHPPAACQSVHQIALSRLWQQILRQTGNAEIRRLTPPHHDRLAGFYNDDDKEAL Kraken2_NZ_CP121074.1 IMICODJL_33742 Prodigal:2.6 104976 114473 - VFG000362(gb|WP_002212777) 97.3 0.0 (irp1) yersiniabactin biosynthetic protein Irp1 VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MDNLRFSSAPTADSIDASIAQHYPDCEPVAVIGYACHFPESPDGETFWQNLLEGRECSRRFTREELLAVGLDAAIIDDPHYVNIGTVLDNADCFDATLFGYSRQEAESMDPQQRLFLQAVWHALEHAGYAPGAVPHKTGVFASSRMSTYPGREALNVTEVAQVKGLQSLMGNDKDYIATRAAYKLNLHGPALSVQTACSSSLVAVHLACESLRAGESDMAVAGGVALSFPQQAGYRYQPGMIFSPDGHCRPFDASAEGTWAGNGLGCVVLRRLRDALLSGDPIISVILSSAVNNDGNRKVGYTAPSVAGQQAVIEEALMLAAIDDRQVGYIETHGTGTPLGDAIEIEALRNVYAPRPQDERCALGSVKSNMGHLDTAAGIAGLLKTVLAVSRGQIPPLLNFHTPNPALKLEESPFTIPVSAQAWQDEMRYAGVSSFGIGGTNCHMIVASLPDALNARLPNTDGGRKSTALLLSAASDSALRRLATDYAGALRDNADASSLAFTALHARRLDLPFRLAAPLNRETAAALSAWAGEKSGELVYSGHGASGKQVWLFTGQGSHWRTMGQTMYRHSTAFADTLDRCFSACSEMLTPSLREAMFNPDSAQLDNMAWAQPAIVAFEIAMAAHWRAEGLKPDFAIGHSVGEFAAAVVCGHYTIEQVMPLVCRRGALMQQCASGAMVAVFADEDTLMPLARQFELDLAANNGTQHTVFSGPEARLAIFCATLSQHDIDYRRLSVTGAAHSALLEPILDRFQAACAGLHAEPGQIPIISTLTADVIDESTLNQADYWRRHMRQPVRFIQSIQMAHQLGARVFLEMGPDAQLVASGQREYRDNAYWIASARRNKEANDVLNQALLQLYAAGVALPWANLLAGDGQRIAAPCYPFDTERYWKERVSPACEPADAALSAGLEVASRAAAALDHPRLEALKQCATRLHAIYVDQLVQRCTGDAIENGVDAMTIMRRGRLLPRYQQLLQRLLNNCVVDGDYRCTDGRYARARPIEHQQRESLLTELAGYCEGFQAIPDTIARAGDRLYEMMSGAEEPVAIIFPQSASDGVEVLYQEFSFGRYFNQIAAGVLRGIVQTRQPRQPLRILEVGGGTGGTTAWLLPELSGVPALEYHFTDISALFTRRAQQKFADYDFVKYSELDLEKEAQSQGFLAQSYDLIVAANVIHATRHIGRTLDNLRPLLKPGGRLLMREITQPMRLFDFVFGPLVLPLQDLDAREGELFLTTAQWQQQCRHAGFSKVAWLPQDDSPTAGMSEHIILATLPGQAVSAVTFTAPSEPVLGQALTDNGDYLADWSDCAGQPEQFNARCQEAWRLLSQRHGDALPVEPPLAAAPEWLGEVRLSWQNEAFSRGQMRVEARHPDGKWLPLSPAAPLPAPQTHYQWRWTPLNIASADHPLTFNFSAGMLARRDELAQYGIIHDPHASSRLMIVEESEDTLALAEKVIAALTASAAGLIVVTRRAWRVEENEALSASHHALWALLRVAANEQPERLIAAIDLAENTPWETLHQGLSAVSLSQRWLAARGNTLWLPSLAPNTGCAAELPANVFTGDNRWHLVTGAFGGLGRLAVNWLREKGARRIALLAPRVDESWLRDVEGGQTRVCRCDVGDTGQMTTVLDDLAANGGIAGAIHAAGVLADAPLQELDDHQRAAVFAVKAQAANQLLQTLRNHDGRYLILYSSAAATLGAPGQSAHALACGYLDGLAQQFSTLDAPKTLSVAWGAWGESGRAATPEMLATLANRGMGALSDAEGCWHLEQAVMRGTPWRLAMRVFTDKMPPLQQALFNISATEKAATPVIPPADDNAFNGSLSDETAVMAWLKKRIAVQLRLSNPASLRPNQDLLQLGMDSLLFLELSSDIQHYLGVRINAERAWQDLSPHGLTQLICSKPETTPAASQPEVLRHDADERYAPFPLTPIQHAYWLGRTHLIGYGGVACHVLFEWDKRHDEFDLAILEKAWNQLIARHDMLRMVVDADGQQRVLATTPEYHIPRDDLRALSPEEQRIALEKRRHELSYRVLPADQWPLFELVVSKIDDCHYRLHMNLDLLQFDVQSFKVMMDDLAQVWRGETLAPLDITFRDYVMAEQARRQTSAWHDAWDYWQEKLPQLPLAPELPVVETPPETPHFTTFKSTIGKKEWQAVKQRWQQQGVTPSAALLTLFAATLERWSRTTAFTLNLTFFNRQPIHPQINQLIGDFTSVTLVDFNFSTPVTLQEQMQQTQQRLWQNMAHSEMNGVEVIRELGRLRGSQRQPLMPVVFTSMLGMTLEGMTIDQAMSHLFGEPCYVFTQTPQVWLDHQVMESDGELMFSWYCMDNVLEPGAAEAMFNDYCAILQAVIAAPESLKTLASGIAGHIPRRRWPLNAQTDYDLRDIEQATLEYPGIRQTRAEIAEQGALTLDIVMVDDPSPSAATPDEHDLAQLALALPLPAQVQLDELEATWRWLEARALQGIAATLNRHGLFTTPEIAHRFSAIVQALSAQASHQRLLRQWLQCLTEREWLIREGESWRCRVPLSEIPEPQEACPQSQWSQALAQYLETCIARHDALFSGQCSPLELLFNEQHRVTDALYRDNPASACLNRYIAQIAALCGAERILEVGAGTAATTAPVLQATRNTRQSYHFTDVSAQFLNDARARFHDESRVSYALFDINQPLDFTAHPEAGYDLIVAVNVLHDASHVVQTLRRLKLLLKAGGRLLIVEATERNSVFQLASVGFIEGLSGYRDFRRRDEKPMLTRSAWQEVLVQAGFTNELAWPTQESSPLRQHLLLARSPGVNRPNKEAVSRYLQQRFGTGLPVLQIRQRETLFTPQHAPSDALIEPPKPTPVAGGNPALEKQVAELWQSLLSRPVARHHDFFELGGDSLMATRMVAQLNRRGIARANLQDLFSHSTLSDFCAHLQAATSGEDNPVPLCQGDGEETLFVFHASDGDISAWLPLASALNRRVFGLQAKSPLRFATLDQMIDEYVGCIRRQQPHGPYVLAGWSYGAFLAAGAAQRLYAKGEQVRMVLIDPVCRQDFCCDNRAALLRLLAEEQTPLALPEHFDQQTPDSQLADFIGLAKTAGMVSQNLTLQAAETWLDNIAHLLRLLTEHTPGESVPVPCLMVYAAGRPARWTPAETEWQGWINNADGYVIEASHWQIMMEAPHVQACAQHITRWLCATSTQLENTL Kraken2_NZ_CP121074.1 IMICODJL_33743 Prodigal:2.6 114561 120668 - VFG000363(gb|WP_002212775) 97.7 0.0 (irp2) yersiniabactin biosynthetic protein Irp2 VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MISGAPSQDSLLPDNRHAADYQQLRERLIQELNLTPQQLHEESNLIQAGLDSIRLMRWLHWFRKNGYRLTLRELYAAPTLAAWNQLILSRSPENAEEETPPDESSWPNMTESTPFPLTPVQHAYLTGRMPGQTLGGVGCHLYQEFEGHCLTASQLEQAITALLQRHPMLHIAFRPDGQQIWLPQPYWNGVTVHDLRHNDAESRQPYLEALRQRLSHRLLRVEIGETFDFQLTLLPDNRHRLHVNIDLLIMDASSFTLFFDELNALLAGESLSAIDTRYDFRSYLLHQQKINQPLRDNARAYWLAKASTLPPAPVLPLTCEPATLREVRNTRRRMIVPATRWHAFSNRAGEYGVTPTMALATCFSAVLARWGGLTRLLLNITLFDRQPLHPSVGAMLADFTNILLLDTACDGDTVSNLARKNQLTFTEDWEHRHWSGVELLRELKRQQRYPHGAPVVFTSNLGRSLYSSRAESPLGEPEWGISQTPQVWIDHLAFEHHGEVWLQWDSNDALFPPALVETLFDAYCQLINQLCDDESAWQKPFADMMPARQRAIRERVNATGAPIPEGLLHEGIFRIALQQPQALAVTDMRYQWNYYELTDYARRCAGRLIECGVQPGDNVAITMSKGAGQLVAVLAVLLAGAVYVPVSLDQPAARREKIYADASVRLVLICQHDASAWSDDIPVLAWQQAIEAEPIANPVVRAPTQPAYIIYTSGSTGTPKGVVISHRGALNTCCDINTRYQVGPGDRVLALSALHFDLSVYDIFGVLRAGGVLVMVMENQRRDPHAWCELIQRHQVTLWNSVPALFDMLLTWCEGFADATPENLRAVMLSGDWIGLDLPARYRAFRPQGQFIAMGGATEASIWSNACEIHDVPAHWRSIPYGFPLTNQRYRVVDEWGRDCPDWVPGELWIGGIGVAEGYFNDPLRSEQQFLTHPDERWYRTGDLGCYWPDGTIEFLGRRDKQVKVGGYRIELGEIESALSQLAGVKQATVLAIGEKEKTLAAYVVPQGEAFCVTDHRDPALPQAWHTLAGTLPCCAISPEISAEQVADFLQHRLLKLKPGHTAGADPLPLMNSLAIQPRWQAVVERWLAFLVTQRRLKPAAEGYQVCAGEERKDEHPNFSGHDLTLSQILRGTRDELSLLNDAQWSPESLAFNHPASAPYIQELATICQQLAQSLQRPVRLLEVGTRTGRAAESLLVQLNAGQVEYVGLEQSQEMLLSARQRLVPRLGARLSPWNADTLAVHAHSADIIWLNNALHRLLPEDPGLLATLQQLAVPGALLYVMEFRQLTPSALLSTLLLTDGQPEALLHNSADWAALFSAAAFNCQHGDEVAGLQRFLVQCPDSQVRRDPRQLQAALAGRLPGWMVPQRIVFLDALPLTANGKIDYQALKRRHTPEAENQAEADLPQGDTEKQVAALWQQLLSTGNVTRETDFFQQGGDSLLATRLTGQLHQAGYEAQLSDLFNHPRLADFAATLRKIDVPVEQPFVHSPEDRYQPFALTDVQQAYLVGCQPGFALGGVGSHFFVEFEIADLDLTRLETVWNRLIARHDMLRAVVRDGQQQVLEQTPHWVIPAHTLHTPEEALRAREKLAHQVLNPEVWPVFDLQVGYVNGMPARLWLCLDNLLLDGLSMQILLAELEHGYRYPQQLPPPLPVTFRDYLQQPSLQSPNPDSLAWWQAQLDDIPPAPALPLRCLPQEVETPRFTRLNGALDSTRWHRLKKRAADAHLTPSAVLLSVWSTVLSAWSAQPEFTLNLTLFDRRPLHPQINQILGDFTSLMLLSWHPGESWLHSAQSLQQRLSQNLNHRDVSAIRVMRQLAQRQNVPAIPMPVVFTSALGFEQDNFLARRNLLKPVWGISQTPQVWLDHQVYESEGELRFNWDFVAALFPAGQVERQFEQYCALLNRMAEDESGWQLPLAALVPPVKFAGQCAERSPRVCPEHSQPHIAADESTVSLICDAFREVVGESVTPAENFFEAGATSLNLVQLHILLQRHEFSTLTLLDLFTHPSPAALADYLAGVVTVEKTKHPRPVRRRQRRI Kraken2_NZ_CP121074.1 IMICODJL_33744 Prodigal:2.6 120859 121818 - VFG034084(gb|WP_000140406) 98.4 9.33e-235 (ybtA) yersiniabactin transcriptional regulator YbtA VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MTESPQTQSEISIHQLVIGKPANDGNIPAQCELLRCSLQEGMDILLWRGHFARPETLQLHDDLGRINFSCILEGTSRFAIQGLRRHTDWELARNRHYITHTPDCRGSASYCGRFESITLSFSPETLALWVPDINAVIKNKIDSQCCCQQQRCNAETHLTAQTLRHALMRMHGGFSHEQKPSTLWLQGQSLVMLSLVLDEHREDASCLSCHFNPMERQKLLRAKDLLLADLTQAPGVAELARESGLSVLKIKRGFRVLFNNSVYGLFQAERMQEARRRLANGNTSVMTVAADLGYANASHFSTAFQKQFGVTPSTFKRVM Kraken2_NZ_CP121074.1 IMICODJL_33745 Prodigal:2.6 122186 123988 + VFG012539(gb|WP_001327262) 98.2 0.0 (ybtP) yersiniabactin ABC transporter ATP-binding/permease protein YbtP VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MSSQSSNTESLSRFPLWQVITPVRRKVILAMALAGLAALTSLGALLFLAWSLRDLRATPDAIPAWPLGGVIGCVVLTFVLRLQAFNTSHYAAFHLENILRSRLARKALQLPPGVLQQMGSGSVAKVMLDDVKSLHIFVADSTPLYARAIIMPLATIVILFWLDWRLAIATLGVLAFGSVVLVLARQRSEDMAQRYHKAREQVSAAVIEFVQAMPVVRTFDSGSTSFLRYQRALEEWGDVLKTWYHKAGFSARFSFSILNPLPTLVVLIWSGYGLLHYGSLDFTAWVAVLLLGSGMAEAVMPMMMLNNLVAQTRLSIQRIYQVLAMPELSLPLSDQQPKEASITFEQVSFHYPQARTGAALQEVSFHVPAGQIVALVGPSGAGKSTVARLLLRYADPDKGHIRIGGVDLRDMQTDTLMKQLSFVFQDNFLFADTIANNIRLGAPDTPLEAVIAAARVAQAHDFISVLPEGYNTRVGERGVFLSGGQRQRITIARAILQDRPILVLDEATAFADPENEAALIKALAAAMRGRTVIMVAHRLSMVTQADVILLFSDGQLREMGNHTQLLAQGGLYQRLWQHYQQAQHWVPGGTQEEVVENERQ Kraken2_NZ_CP121074.1 IMICODJL_33746 Prodigal:2.6 123975 125777 + VFG003507(gb|WP_005168689) 97.3 0.0 (ybtQ) yersiniabactin ABC transporter ATP-binding/permease protein YbtQ VF0136 Yersiniabactin VFC0272 Nutritional/Metabolic factor One of the major differences between low- and high-pathogenicity Yersinia lies in their ability to capture the iron molecules necessary for their systemic dissemination in the host Yeriniabactin belongs to a small sub-group of phenolate siderophores and has an affinity for ferric iron (KD=4 x 10-36) much higher than for ferrous iron. FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron YbtA is an AraC-like regulator required for transcription of fyuA/psn, irp2 and ybtP, also downregulate its own transcription; In the presence of iron, Fur, a cytosolic protein that on binding ferrous iron changes conformation and binds DNA at a specific site called a Fur box, thus preventing transcription, downregulates transcription of fyuA/psn, irp2 and other iron-regulated genes MKDNNPADNLAWRVIWRQLISSVGSQARMLRRSMLALLLAAFMQGVAFACLYPIIDALLRGDAPQLLNWAVAFSVATIVTLALRWYGLGFEYRGHLAQATHELRLRLGEQLRRVPLEKLQRGRAGEMNALLLGSVDENLNYVIAIANILLLTIITPLTASLATWWIDWRLGLVMLLIFPLLVPFYYWRRPAMRRQMQTLGEAHQRLSGDIVEFAQGMMVLRTCGSDADKSRALLAHFNALENLQTRTHRQGAGATMLIASVVELGLQVVVLSGIVWVVTGNLNLAFLIAAVAMIMRFAEPMAMFISYTSVVELIASALQRIEQFMAIAPLPVAAQNEMPERYDIRFDNVSYCYEEGDGHALNNVSLTFPAASMSALVGASGAGKTTVTKLLMRYADPQQGQISIGGVDIRRLTPEQLNSLISVVFQDVWLFDDTLLANIRIARPQATRQAVEEAARAAQCLEFISRLPQGWLTPLGEMGGQLSGGERQRISIARALLKNAPVVILDEPTAALDIESELAVQKAIDNLVHNRTVIIIAHRLSTIAGAGNILVMEEGQVVEQGTHAQLLSRHGRYQALWQAQMAARAWRDEGVSASGEWVHE Kraken2_NZ_CP121074.1 IMICODJL_33747 Prodigal:2.6 125770 127050 + VFG034033(gb|WP_001286280) 97.9 8.659999999999999e-285 (ybtX) yersiniabactin-associated zinc MFS transporter YbtX VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MSDVQSNVKPLTLTTGRVIFAIAGVYVTQSLVSALSMQSLPALVRAAGGSLALAGATTLFMLPWALKFIWAPWIERWRLPPGSPERRSRMLILRGQVALAAILTIAAAIGWFGREGGFPDTQIVALFVLFMVAGTVASTIDIASDGFCVDQLTRAGYGWGNSVQVGGSYLGMMCGGGVFLMLSAASGWPVAMLMMAVLIMALSLPLWRITEPTRTETIPHIPALGYALRRKQARLGLLLVLMLNSGMRFVLPLLAPLLLDHGLSMSALGALFSGGNIAAGIAGTLAGGLLMKYTSPGRALLMTYGVQGIALLAVVMTLMMVPGHLLLPILQCLVIVQSISLACALVCLYATLMSLSSPLQAGVDFTLFQCTDAAIAILAGVIGGVVAQHFGYATCFLFAGAFTLLAAWVAYIRLYSARELMTSAID Kraken2_NZ_CP121074.1 IMICODJL_33748 Prodigal:2.6 127078 128409 + VFG012529(gb|WP_000703040) 95.8 2.17e-305 (ybtS) yersiniabactin biosynthesis salicylate synthase YbtS VF1115 Yersiniabactin siderophore VFC0272 Nutritional/Metabolic factor MKISEFLHLALPEEQWLPTISGVLRQFAEEECYVYECQPCWYLGKGCQVRLHINADGTQATFIDDAGEQQWAVDSIADCARRFMAHPQVKGRRVYGQVGFNFAAHAREIAFNAGEWPLLTLTVPREELIFEKGNVTVYADSADGCRRLCEWVKEARTTTQNAPLAVDTALNGEMYKQQVARAVAEIRRGEYAKVIVSRAIPLPSRIDMPATLLYGRQANTPTRSFMFRQEGREALGFSPELVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIVELESICQAGSVVVEDLMSVRQRGSVQHLGSSVSGNLAENKDAWDAFTALFPSITASGIPKNAALNAIMQIETTPRELYSGAILLLDDTRFDAALVLRSVFQDSQRCWIQAGAGIIAQSTPERELMETREKLASIVPYLMAAKLKAGVME Kraken2_NZ_CP120957.1 IMICODJL_33819 Prodigal:2.6 1 963 + VFG045767(gb|WP_012979404) 71.9 8.22e-156 (lvhB11) P-type conjugative transfer ATPase TrbB VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MTDQKPEHNSIKERAKKKLERDMGPELLAALNDPKTVEIMLNADGKLWLERLGEPMKCIGTLRVAQAQAIIETIAGYHGKEVTRSKPILEGELPLDGSRFAGQLPPVVPAPTFAIRKKAVAIFTLDQYVERGIMTAPQREALIAAVRAHRNILVIGGTGSGKTTLVNAIINEMVIQDPTERVFIIEDTGEIQCAAENYVQYHTSIDVNMTALLKTTLRMRPDRILVGEVRGPEALDLLMAWNTGHEGGAATLHANNAKAGLDRLAMLISMHPDSPKPIEPLIGEAVHVVVHIARVEGSRRIQEILEVSGFANGQYITKTL Kraken2_NZ_CP120957.1 IMICODJL_33822 Prodigal:2.6 1756 4314 + VFG045766(gb|WP_012979408) 67.3 0.0 (lvhB4) conjugal transfer protein TrbE VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MIEAIAIAIAVLGAVLLLILFARIRAVDAELKLKKHRAKDAGLADLLNYAAVVDDGVIVGKNGSFMAAWLYKGDDNASSTEEQREMVSFRINQALAGLGNGWMVHVDAVRRPAPNYSERGVSSFPDSVSFAIDEERRRLFEGLGAMFEGYFVLTVTWFPPVLAQRKFVELMFDDDAVAPDHTARTTGLIAQFKREITSLESRLSSAVKMTRLRGQKVVSEEGREVTHDDFLSWLQFCVTGLHHPVMLPSNPMYLDAVIGGQELWGGVVPKIGRKFIQVVAIEGFPLESTPGVLSALAELPSEYRWSSRFIFMDQHESLKHLDKFRKKWKQKIRGFFDQVFNTNTGSINQDAAAMVGDAEAAIAEVNSGLVAAGYYTSVVVLMDEDRERLAASALLVEKAVNRLAFAARIETINTLDAYLGSLPGHGVENVRRPLINTMNLADLLPTSSIWTGSATAPCPMYPPLSPALMHCVTVGATPFRLNLHVRDLGHTFMFGPTGAGKSTHLGIIAAQLRRYAGMSIYAFDKGMSMYPLAAGIRAATKGKSGLHFTVAADDDRLAFCPLQFLETKGDRAWAMEWIDTILALNGVNTTPAQRNEIGNAIMSMHASGARTLSEFSVTIQDEAIREAIKQYTVDGSMGHLLDAEEDGLSLSDFTVFEIEELMNLGEKFALPVLLYLFRRIERALKGQPSVIILDEAWLMLGHPAFRAKIREWLKVLRKANCLVLMATQSLSDAANSGILDVIVESTATKIFLPNVYARDEDTSALYRRMGLNARQIEILATAIPKRQYYYVSENGRRLYDLALGPMALAFVGASDKESVATIKSLEAKFGHEWVHEWLAGRGLNLNDYLEAA Kraken2_NZ_CP120957.1 IMICODJL_33849 Prodigal:2.6 28169 30082 - VFG045768(gb|WP_012979416) 63.7 3.56e-281 (lvhD4) type IV secretory system conjugative DNA transfer family protein VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MKIKMNNAVGPQVRTAKPKPSKLLPVLGAASMVGGLQAATQFFAHTFAYHATLGPNVGHVYAPWSILHWTYKWYSQYPDEIMKAGSMGMLVSTVGLLGVAVAKVVTSNSSKANEYLHGSARWAEKKDIQAAGLLPRERNVLEIVTGKAAPTATGVYVGGWQDKDGNFFYLRHSGPEHVLTYAPTRSGKGVGLVVPTLLSWGASSVITDLKGELWALTAGWRQKHAKNKVLRFEPASTSGGVCWNPLDEIRLGTEYEVGDVQNLATLIVDPDGKGLDSHWQKTAFALLVGVILHALYKAKDEGGTATLPSVDAMLADPNRDIGELWMEMATYGHVDGQNHHAIGSAARDMMDRPEEEAGSVLSTAKSYLALYRDPVVARNVSRSDFRIKQLMHEDDPVSLYIVTQPNDKARLRPLVRVMVNMIVRLLADKMDFEGGRPVAHYKHRLLMMLDEFPSLGKLEIMQESLAFVAGYGIKCYLICQDINQLKSRETGYGHDESITSNCHVQNAYPPNRVETAEHLSRLTGQTTVVKEQITTSGRRTAAMLGQVSRTYQEVQRPLLTPDECLRMPGPKKNAQGEIEEAGDMVIYVAGYPAIYGKQPLYFKDPVFSARAAIPAPKVSDRLRAVAQAETEGEGITI Kraken2_NZ_CP120959.1 IMICODJL_34404 Prodigal:2.6 101673 102254 + VFG000077(gb|NP_465991) 78.2 8.48e-108 (clpP) ATP-dependent Clp protease proteolytic subunit VF0074 ClpP VFC0282 Stress survival 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes Serine protease involved in proteolysis and is required for growth under stress conditions MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLESQDPEKDIHIYINSPGGSITAGMAIYDTMQFIKPQVSTICIGMAASMGAFLLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILFLREKLNQILADRTGQPLEVLQRDTDRDNFMTAEKALEYGLIDKIFTNR Kraken2_NZ_CP120945.1 IMICODJL_35516 Prodigal:2.6 3098 4537 - VFG000843(gb|WP_001213545) 100.0 0.0 (hlyD) Hemolysin D VF0207 Hemolysin VFC0235 Exotoxin Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation; The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains Pro-HlyA is activated in the cytoplasm to the hemolytically active form by HlyC, a fatty acid acyltransferase; C-terminal peptide Trp914-Arg936 is a major receptor-binding region; the HlyA export machinery consists of two specific inner membrane (IM) proteins: HlyB, HlyD, and TolC, a multifunctional protein located in the outer membrane (OM); HlyB is inserted in the IM by eight hydrophobic alpha-helical transmembrane domains (TMDs). HlyD is a membrane of the membrane fusion protein (MFP) family. HlyD is anchored in the cytoplasmic membrane by a single TMD and possesses a large periplasmic domain within the C-terminal 100 amino acids Cytotoxic to many types of cells: erythrocytes, granulocytes, monocytes, endothelial cells and renal epithelial cells; stimulating the release of IL-1beta and TNF HlyA first binds a receptor on the cell surface, a beta2-integrin in leukocytes or glycophorin in red blood cells, then becomes inserted in the cell membrane. Calcium binding to the glycine-rich repeats is essential for toxin activity MRFYMKGLWDLVCRYKTVFSDVWKIRHTLDAPVREKDEYAFLPAHLELIETPVSRRSHFVVWSILLFVIISLLLSVLGKVEVVSVANGKFTHSGRSKEIKPIENAIVEKIMVKDGSFVKKNDPLVELTVPGVESDILKSEASLLYEKTEQYRYAILSESIQRNELPEIRITDFPGGEDNAGGEHFQRVSSLIKEQFMTWQNRKNQKQLTLNKKIVERDAALARVSLYEHQVSQEGRKLNDFKYLLNKKAVSQHSVMEQENSYIQAKNEHAVWLAQVSQLEKEIELVREELALETNIFRSEIIEKHRKSTDNIVLLEHELEKNRQRKASSFIKAPVSGTVQELNIHTEGGVVTTAETLMIIVPDNDILEVTASVLNKDIGFIQPGQEVVIKVDAYPYTRHGYLTGKVKNITADSVSVPDTGLVFNVIISVDRNDIQGERKKIPVTAGMTVMAEIKTGVRSVISYLLSPLKETINESLRER Kraken2_NZ_CP120945.1 IMICODJL_35517 Prodigal:2.6 4541 6661 - VFG000841(gb|WP_000987091) 100.0 0.0 (hlyB) Hemolysin B VF0207 Hemolysin VFC0235 Exotoxin Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation; The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains Pro-HlyA is activated in the cytoplasm to the hemolytically active form by HlyC, a fatty acid acyltransferase; C-terminal peptide Trp914-Arg936 is a major receptor-binding region; the HlyA export machinery consists of two specific inner membrane (IM) proteins: HlyB, HlyD, and TolC, a multifunctional protein located in the outer membrane (OM); HlyB is inserted in the IM by eight hydrophobic alpha-helical transmembrane domains (TMDs). HlyD is a membrane of the membrane fusion protein (MFP) family. HlyD is anchored in the cytoplasmic membrane by a single TMD and possesses a large periplasmic domain within the C-terminal 100 amino acids Cytotoxic to many types of cells: erythrocytes, granulocytes, monocytes, endothelial cells and renal epithelial cells; stimulating the release of IL-1beta and TNF HlyA first binds a receptor on the cell surface, a beta2-integrin in leukocytes or glycophorin in red blood cells, then becomes inserted in the cell membrane. Calcium binding to the glycine-rich repeats is essential for toxin activity MMSKCSSHNSLYALILLAQYHNITVNAETIRHQYNTHTQDFGVTEWLLAAKSIGLKAKYVEKHFSRLSIISLPALIWRDDGKHYILSRITKDSSRYLVYDPEQHQSLTFSRDEFEKLYQGKVILVTSRATVVGELAKFDFSWFIPSVVKYRRILLEVLTVSAFIQFLALITPLFFQVVMDKVLVHRGFSTLNIITIAFIIVILFEVILTGARTYIFSHTTSRIDVELGAKLFRHLLALPVSYFENRRVGETVARVRELEQIRNFLTGQALTSVLDLFFSVIFFCVMWYYSPQLTLVILLSLPCYVIWSLFISPLLRRRLDDKFLRNAENQAFLVETVTAINTIKSMAVSPQMIATWDKQLAGYVASSFRVNLVAMTGQQGIQLIQKSVMVISLWMGAHLVISGEISIGQLIAFNMLAGQVIAPVIRLAHLWQDFQQVGISVERLGDVLNTPVEKKSGRNILPEIQGDIEFKNVRFRYSSDGNVILNNINLYISKGDVIGIVGRSGSGKSTLTKLLQRFYIPETGQILIDGHDLSLADPEWLRRQIGVVLQENILLNRSIIDNITLASPAVSMEQAIEAARLAGAHDFIRELKEGYNTIVGEQGVGLSGGQRQRIAIARALVTNPRILIFDEATSALDYESENIIMKNMSRICKNRTVIIIAHRLSTVKNANRIIVMDNGFISEDGTHKELISKKDSLYAYLYQLQA Kraken2_NZ_CP120945.1 IMICODJL_35518 Prodigal:2.6 6711 9707 - VFG000840(gb|WP_000217739) 100.0 0.0 (hlyA) Hemolysin A VF0207 Hemolysin VFC0235 Exotoxin Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation; The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains Pro-HlyA is activated in the cytoplasm to the hemolytically active form by HlyC, a fatty acid acyltransferase; C-terminal peptide Trp914-Arg936 is a major receptor-binding region; the HlyA export machinery consists of two specific inner membrane (IM) proteins: HlyB, HlyD, and TolC, a multifunctional protein located in the outer membrane (OM); HlyB is inserted in the IM by eight hydrophobic alpha-helical transmembrane domains (TMDs). HlyD is a membrane of the membrane fusion protein (MFP) family. HlyD is anchored in the cytoplasmic membrane by a single TMD and possesses a large periplasmic domain within the C-terminal 100 amino acids Cytotoxic to many types of cells: erythrocytes, granulocytes, monocytes, endothelial cells and renal epithelial cells; stimulating the release of IL-1beta and TNF HlyA first binds a receptor on the cell surface, a beta2-integrin in leukocytes or glycophorin in red blood cells, then becomes inserted in the cell membrane. Calcium binding to the glycine-rich repeats is essential for toxin activity MTVNKIKNIFNNATLTTKSAFNTASSSVRSAGKKLILLIPDNYEAQGVGINELVKAADELGIEIHRTERDDTAIANQFFGAAEKVVGLTERGVAIFAPQLDKLLQKYQKVGSKIGGTAENVGNNLGKAGTVLSALQNFTGIALSGMALDELLRKQREGEDISQNDIAKSSIELINQLVDTVSSINSTVDSFSEQLNQLGSFLSSKPRLSSVGGKLQNLPDLGPLGDGLDVVSGILSAVSASFILGNSDAHTGTKAAAGIELTTQVLGNVGKAVSQYILAQRMAQGLSTTAASAGLITSAVMLAISPLSFLAAADKFERAKQLESYSERFKKLNYEGDALLAAFHKETGAIDAALTTINTVLSSVSAGVSAASSASLIGAPISMLVSALTGTISGILEASKQAMFEHVAEKFAARINEWEKEHGKNYFENGYDARHAAFLEDSLSLLADFSRQHAVERAVAITQQHWDEKIGELAGITRNADRSQSGKAYINYLENGGLLEAQPKEFTQQVFDPQKGTIDLSTGNVSSVLTFITPTFTPGEEVRERKQSGKYEYMTSLIVNGKDTWSVKGIKNHKGVYDYSKLIQFVEKNNKHYQARIISELGDKDDVVYSGAGSSEVFAGEGYDTVSYNKTDVGKLTIDATGASKPGEYIVSKNMYGDVKVLQEVVKEQEVSVGKRTEKIQYRDFEFRTGGIPYDVIDNLHSVEELIGGKHDDEFKGGKFNDIFHGADGNDYIEGNYGNDRLYGDDGDDYISGGQGDDQLFGGSGNDKLSGGDGNNYLTGGSGNDELQAHGAYNILSGGTGDDKLYGGGGIDLLDGGEGNDYLNGGFGNDIYVYGQNYGHHTIADEGGKGDRLHLSDISFDDIAFKRVGNDLIMNKAINGVLSFNESNDVNGITFKNWFAKDASGADNHLVEVITDKDGREIKVDKIPHNNNERSGYIKASNIASEKNMVNITSVANDINKIISSVSGFDSGDERLASLYNLSLHQNNTHSTTLTTTV Kraken2_NZ_CP120945.1 IMICODJL_35519 Prodigal:2.6 9709 10224 - VFG000842(gb|WP_000839950) 100.0 1.45e-128 (hlyC) Hemolysin C VF0207 Hemolysin VFC0235 Exotoxin Best-characterized RTX protein secreted by a type I secretion system: the structural gene encoding the hemolysin (hlyA) is part of an operon that also encodes a dedicated export system (HlyB and HlyD comprising a type I secretion system) and a toxin modifying enzyme (HlyC). The HlyC protein is responsible for acylation of HlyA, resulting in toxin activation; The hly operon is found on a plasmid of EHEC O157:H7, while the hly operon is often located adjacent to the P fimbrial genes on the same pathogenicity island on the chromosome of UPEC strains Pro-HlyA is activated in the cytoplasm to the hemolytically active form by HlyC, a fatty acid acyltransferase; C-terminal peptide Trp914-Arg936 is a major receptor-binding region; the HlyA export machinery consists of two specific inner membrane (IM) proteins: HlyB, HlyD, and TolC, a multifunctional protein located in the outer membrane (OM); HlyB is inserted in the IM by eight hydrophobic alpha-helical transmembrane domains (TMDs). HlyD is a membrane of the membrane fusion protein (MFP) family. HlyD is anchored in the cytoplasmic membrane by a single TMD and possesses a large periplasmic domain within the C-terminal 100 amino acids Cytotoxic to many types of cells: erythrocytes, granulocytes, monocytes, endothelial cells and renal epithelial cells; stimulating the release of IL-1beta and TNF HlyA first binds a receptor on the cell surface, a beta2-integrin in leukocytes or glycophorin in red blood cells, then becomes inserted in the cell membrane. Calcium binding to the glycine-rich repeats is essential for toxin activity MKSNAFDVMGKVAWLWACSPLHKKWPLSVFAINVIPAIQTNQFALLIKDELPVAFCSWASLDLECEVKYINDVTSLYAKDWMSGERKWFIDWIAPFGHNMELYKYMRKKYPYELFRAIRLDESSKTGKIAEFHGGGIDKKLASKIFRQYHHELMSEVKNRQDFNFNIEKEN Kraken2_NZ_CP120945.1 IMICODJL_35522 Prodigal:2.6 12115 12516 - VFG040943(gb|WP_000971918) 100.0 2.84e-94 (eptO) GspS family T2SS pilot lipoprotein variant EptO VF1178 Etp VFC0086 Effector delivery system MMGNILKKLNCIASLLVLVTISGCHQSPSIHKQATVPPSEQLEQMASIVSATRYLKMRCNRSDLPDEQSILNVANRIAIGKGWQSLTQEDIRKHSDDIYVRLTRDSTPEYIKCREFNRRLVPFIGELLARGRG Kraken2_NZ_CP120945.1 IMICODJL_35523 Prodigal:2.6 12608 13441 - VFG040942(gb|WP_000096786) 100.0 4.68e-207 (Z_RS28450) A24 family peptidase VF1178 Etp VFC0086 Effector delivery system MSSLPEFAVDYPLLWLICTGGLGGVTGSFLNVVIHRLPIMLERRWRREALTLLAHSVPESGPAFNLMIPQSHCPCCFHPLGIRDNIPLLSYLFLKGKSRCCGERIPVYYPLVEITNSVLFILAASRFPPGLTLAAAWLFISMLLVLAVIDCHTALLPDVLTLPLLWLGLLFSLQRGVVTLEEAVVGAVSGYLCLWGLYWLFRFATGREGLGYGDFKLAAALGAWMGWQALPSILLFASVSGLIVTVLLRIVTATDFTRPLPFGPWLALSGVCHFLLM Kraken2_NZ_CP120945.1 IMICODJL_35524 Prodigal:2.6 13499 14011 - VFG040941(gb|WP_001004187) 100.0 5.45e-119 (Z_RS28445) type II secretion system protein M VF1178 Etp VFC0086 Effector delivery system MNELKKRLQYVSPRERRLLIGCVALLVVVFVYYVLWQPWLIREDKWRTVVTREKNTVEWMKQQVPNIKRREASMPEQGEPLGLSAAVTRTSAAYGVSVTRLQPQGERLAVTLAPVEFNALMQWLTQLERRHRIRTMVFDVAAQGNPPGQVTVNRLVLSQDDVNKDASLSR Kraken2_NZ_CP120945.1 IMICODJL_35525 Prodigal:2.6 13998 15095 - VFG040940(gb|WP_071525076) 99.7 1.5800000000000002e-269 (gspL) type II secretion system protein GspL VF1178 Etp VFC0086 Effector delivery system MAVGETDPQLVGLLSRYPAWVLVPSGRIAFHQVTLPHRTWRQRLQVLPFLLEEQLATDIEQLHFAILHQSGDRCDVAVVEKAVMHRWLAYCGQLGVREVRLLPDVLMLPLATEGWSAVKLAGQWLFRRDRYAGMTVELSWLTHFLSLTAPPVIESYSVPPVPCPGPKTTEWRNQPGRDLLQLVAEGDGYDGADLRQGEFARQGTWYARFRPWRYVAGALLACVFLAGSNAGLAHYRLWQQAQFWRYESVRVYQQLFPSEKAVKDPRRQMLRHLQQSTGNNIPELGSVMRQLQQLLSETSTIRLQALAWDSSSQTLKIDLQAASFQALEHFQQIAGEKYLIQPGEIRQQPQGVESRLILRVNNERA Kraken2_NZ_CP120945.1 IMICODJL_35526 Prodigal:2.6 15209 16186 - VFG040939(gb|WP_000776550) 100.0 1.3099999999999999e-228 (gspK) type II secretion system minor pseudopilin GspK VF1178 Etp VFC0086 Effector delivery system MKLREQGVALLVVLLILSLMVTIAAVIAERNGRTFLRTVAQLDQLQAKWDGYTAETIAKQILQRSRQESPRKTHLAQNWAQSERQFETRGGDVRGQIVDAQACFNLNAINYGVVDLTSIPYAARIFQQLLINLQVELLQARQVTAALRDWIDRDDKPVRGGAEDEVYMGMEPPYLAANQPMQDVSELRLIRGIDARLYRKLLPYVCVLPTSDLSVNVNTLLDSQAPLLAALFLTKPDSLPVTELLQRRPRTGWESVAAFLDAPPLKDIDTSAAMPVLAVSSNYFLVRLHVRSGEHLFSQQTLMQWREERFRIIQRQYGLTMREVP Kraken2_NZ_CP120945.1 IMICODJL_35527 Prodigal:2.6 16183 16782 - VFG040938(gb|WP_000082782) 100.0 2.82e-142 (gspJ) type II secretion system minor pseudopilin GspJ VF1178 Etp VFC0086 Effector delivery system MSQQRVKGFTLLEMLLALAVFAALSISAFQVLQGGIRAHELSRDKVQRLAELQRGISQMERDLTQMLPRHSRGNEGLLLAAPHLLKSDDWGISFTRNSWLNPAGMLPRPELQWVGYRLRQQKLERLSYFHVDHPSGVSPDVRVMLDGVHAFRLRFFVNGDWQARWDSTGILPQAVEVTLVMDDFAELPRLFLVSKETAE Kraken2_NZ_CP120945.1 IMICODJL_35528 Prodigal:2.6 16779 17144 - VFG040937(gb|WP_000173396) 100.0 3.89e-76 (gspI) type II secretion system minor pseudopilin GspI VF1178 Etp VFC0086 Effector delivery system MKGQEGMTLLEVIVALVVFALAGMALMQASTQQAAGIGRMEEKVLAGWLADNQMVQLQLEKTWPENGWGEKTISFAGTEWYLRWGGPDSDVPQPRSLEVEVRRTKEETSALVSLRSSVVRE Kraken2_NZ_CP120945.1 IMICODJL_35529 Prodigal:2.6 17141 17695 - VFG040936(gb|WP_000082929) 100.0 3.6300000000000005e-133 (gspH) type II secretion system minor pseudopilin GspH VF1178 Etp VFC0086 Effector delivery system MSQRGFTILEMMLILLLMGITAGLVLMSFPDSAQNHLQQQRERLQAQLDYALDRSQQDGLLMGIQVRFDGWKFKVLQRGTAESPPTLAEGGDIWQGYVWQTWQPRRAAMGGKLPDDVRLELQYLRGLQWMSEHDDGAEPDILLLPGGEVTPFRLLFRQVGEEAVVGLQVDENGLMTLFEGEVSL Kraken2_NZ_CP120945.1 IMICODJL_35530 Prodigal:2.6 17692 18126 - VFG040935(gb|WP_001231211) 100.0 2.26e-103 (gspG) type II secretion system major pseudopilin GspG VF1178 Etp VFC0086 Effector delivery system MRKQHQRGFTLLEIMVVIVILGVLASLVVPNLMGNKDKADRQKVMSDLVALESTLDMYRLDNNRYPTTEQGLRALVSKPTVQPEPRNYRQDGYIRRLPQDPWGGDYQLLNPGQYSDIDIFSPGPDGVPNTEDDIGNWTLGNAQP Kraken2_NZ_CP120945.1 IMICODJL_35531 Prodigal:2.6 18157 19380 - VFG040934(gb|WP_001173152) 100.0 2.02e-278 (gspF) type II secretion system inner membrane protein GspF VF1178 Etp VFC0086 Effector delivery system MALFHYQASDIHGRKRSGILEADSARHARQLLREQALIPVRLDEKQVHHKHSLRSILRFRPRGGSSAELALLTRQLATLVAASLPLEEALDALLRQSEKPRQRNLIAAVRTKVLEGHSLAAAMGMFPGTFERLYCAMVAAGETSGRLDVVLSRLADYTEQRQIMRNRLLQALLYPCVLTLVAVGVIAILLTAVVPKVVEQFIHMKQTLPLSTRVLMGAAEVSQTWGPWLLLAAALGGIAGRMILHQPSQRLAFHHLLLRLPVVGRISRGLNTARYARTLSILNASAVPLLQAMHISGDVLSNDWARHQLATAAELVREGVSLHQALEQTSLFPPMMRHMIASGENSGELDSMLERAADNQDREFSTQMQLALGLFEPLLVVGMAGVVLFIVLAILQPLLQLNNMMNM Kraken2_NZ_CP120945.1 IMICODJL_35532 Prodigal:2.6 19382 20887 - VFG040933(gb|WP_000092338) 100.0 0.0 (gspE) type II secretion system ATPase GspE VF1178 Etp VFC0086 Effector delivery system MSRVVQNVSESRPLLPFSFSRTQRILLLREQEGNRVFCMEDTPASALLEVRRVAEGPLNVTTVSAEAFEKQLVSSYQRDSDEARQMMAEIGNEMDFYTVAGELPDREDLLDANDDAPIIRLINAMLTEAIKEKASDIHIETYERHLQVRFRIDGVLREILRLHRNLASLLISRIKVMARLDIAEKRVPQDGRMVLRIGGRAVDVRVSTLPSNHGERIVLRLLDKNSVSLDLAALGMSQQNQRHIDALIRRPHGIILVTGPTGSGKSTTLYAALSLLNPRDRNIMTVEDPVEYELDGISQTQVNPKVDMTFARSLRAILRQDPDVVLVGEIRDGETAQIAVQASLTGHLVLSTLHTNSAAGALSRLQDMGIPPFLLSTSLLAVLAQRLVRTLCPRCRQPCQVSTELAMDMDIPPETTIWQPAGCQHCSFTGYHGRTGIHELLLIDDRIRTAIYQGEGELGITRLAGSRYLTLRGDGRQKVLAGETSWEEVVRVTESRLQEEE Kraken2_NZ_CP120945.1 IMICODJL_35533 Prodigal:2.6 20887 22854 - VFG040932(gb|WP_001302177) 100.0 0.0 (etpD) variant type II secretion system secretin EtpD VF1178 Etp VFC0086 Effector delivery system MFRKWLNGRLPVLVFTTVILGAIPGWGAEFSANFKDTDIQEFINTVSKNLHKTVIINPDVQGTITVRSYDMLNEEQYYQFFLSVLDVYGFAVVDMHNGILKVVRSKDAKTSAVPVASDVSPGTGDEVVTRVVPVSNVAARDLAPLLRQLNDNAGAGSVVHYEPSNVLLMTGRAAVMKRLMEIVERVDKVGNRSVATVPLTYASATDVARLVTELTKETDKTAIPAWMTAKLVADERTNSVLVSGEPISQQRIISIIKQLDRQEDVQGNTKVIYLKYAKAKDLVEVLTGISSSIENDSKKSPSTEALRKGVTIKSHEQTNALILTGAPDVIRDLENVISQLDIRRPQVLVEAIIAEIQDADGLNLGIQWVNKHAGVAQFTSTGLPITTMVQTRQNEILDSDQSNALSMFNGIAAGFYQGNWAMLLTALSTSSKNDILATPSIVTLDNMEATFNVGQEVPVLSGSQTTSGDNIFNTVERKTVGIKLRVKPQINEGDSVLLEIEQEVSGVADTAVATTTDLGATFNTRTVTNAMLVGNGETVVVGGLLDKSIRGSESKVPLLGDIPVLGHLFRAKSEQTAKRNLMLFIRPTIIRERDGFRHASAEKYQSFNQEQVQSRGKETTALTLNEEQLRLSPDQDDTAFRKVKAAIAAFYAQEM Kraken2_NZ_CP120945.1 IMICODJL_35534 Prodigal:2.6 22855 23730 - VFG040931(gb|WP_001302175) 100.0 7.69e-204 (gspC) type II secretion system protein GspC VF1178 Etp VFC0086 Effector delivery system MLFFLSFRGDRGLFIKDIVLKMLTPNRLLCVILLIAGYQLVSVIHHFWLTQAASVPGLSRVSAPETAVTGDQTEERFVFTLFGRASPLSSEGRAQETMPSLSDDLLSGEDLDVRGILYSSVAEHSVAIFAHNNRQFSLSVGEKVPSYDATISAIFSDHIVINYQGKTVSLPLRYDNTEKKNAYDNNNLTVGDVITQDNFRVESVFDIMSFSAVTVNNTLSGYRLIPGKHSSLFYNAGLHDNDLAVSVNGSELRDTRQAQQIMKQLPELKEIKITVERDGQLYDAFIAVGEN Kraken2_NZ_CP120945.1 IMICODJL_35535 Prodigal:2.6 23817 26477 - VFG000846(gb|WP_001358886) 100.0 0.0 (stcE) metalloprotease VF0209 StcE Secreted protease of C1 esterase inhibitor from EHEC VFC0251 Exoenzyme Encoded within the pO157 plasmid that belongs to the family of serine protease inhibitor; secreted by a type II secretory apparatus also encoded within pO157 plasmid and is transcriptionally activated by the Ler, so the production of StcE is coupled with activation of the LEE genes Substitution of Asp for Glu at StcE position 435 within the consensus metalloprotease active site removes its ability to digest C1-INH and to aggregate T cells Specifically cleaves the C1 esterase inhibitor (C1-INH), which is an essential regulator of classical and alternative complement, intrinsic coagulation and contact activation, therefore disrupts complement cascade and contributes to the tissue damage, intestinal oedema and thrombotic cytopenia MKLKYLSCTILAPLAIGVFSATAADNNSAIYFNTSQPINDLQGSLAAEVKFAQSQILPAHPKEGDSQPHLTSLRKSLLLVRPVKADDKTPVQVEARDDNNKILGTLTLYPPSSLPDTIYHLDGVPEGGIDFTPHNGTKKIINTVAEVNKLSDASGSSIHSHLTNNALVEIHTANGRWVRDIYLPQGPDLEGKMVRFVSSAGYSSTVFYGDRKVTLSVGNTLLFKYVNGQWFRSGELENNRITYAQHIWSAELPAHWIVPGLNLVIKQGNLSGRLNDIKIGAPGELLLHTIDIGMLTTPRDRFDFAKDKEAHREYFQTIPVSRMIVNNYAPLHLKEVMLPTGELLTDMDPGNGGWHSGTMRQRIGKELVSHGIDNANYGLNSTAGLGENSHPYVVAQLAAHNSRGNYANGIQVHGGSGGGGIVTLDSTLGNEFSHEVGHNYGLGHYVDGFKGSVHRSAENNNSTWGWDGDKKRFIPNFYPSQTNEKSCLNNQCQEPFDGHKFGFDAMAGGSPFSAANRFTMYTPNSSAIIQRFFENKAVFDSRSSTGFSKWNADTQEMEPYEHTIDRAEQITASVNELSESKMAELMAEYAVVKVHMWNGNWTRNIYIPTASADNRGSILTINHEAGYNSYLFINGDEKVVSQGYKKSFVSDGQFWKERDVVDTREARKPEQFGVPVTTLVGYYDPEGTLSSYIYPAMYGAYGFTYSDDSQNLSDNDCQLQVDTKEGQLRFRLANHRANNTVMNKFHINVPTESQPTQATLVCNNKILDTKSLTPAPEGLTYTVNGQALPAKENEGCIVSVNSGKRYCLPVGQRSGYSLPDWIVGQEVYVDSGAKAKVLLSDWDNLSYNRIGEFVGNVNPADMKKVKAWNGQYLDFSKPRSMRVVYK Kraken2_NZ_CP120945.1 IMICODJL_35537 Prodigal:2.6 27395 28393 - VFG013084(gb|WP_004996485) 65.2 3.2e-152 (msbB2) lauroyl-Kdo(2)-lipid IV(A) myristoyltransferase VF0981 MsbB2 VFC0346 Others MVPPSAVLCYHNEISRQIPVNMKNIRTEFIPRFNLTLCFPRYWMTWTGIGIICVFAMVPPALRDPLLGKLGMLVGRLGKSARQRALINLSLCFPEYSDKEKENIVDAMFATASMAVVLMAELALSGPDKISHRIRWNGLEIVEKMAQNNEKVIFLVPHAWGVDIPAMLMAASGRKMAAMFHNQRNPVVDYVWNSVRRRFGGKLHARNDGIASFVRSVRQGYWGYYLPDQDHGPEFSEFADFFATYKATLPVIGRLSRISGARIIPLFPVYDGKTHHLTIHVSPPLAIRQKSDAHIARQINEVVENFVRPHPEQYTWILKLLKTRKEGEEDPY Kraken2_NZ_CP120945.1 IMICODJL_35538 Prodigal:2.6 28467 30188 - VFG034689(gb|WP_000550559) 100.0 0.0 (ibeC) phosphoethanolamine transferase CptA VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MHLNTGQNRPTFSWSALGWAIFYFGFFSTLLQVIIFSSGYSGTNGIRDSLLFSCLWLIPVFLYPDRIKIIAAVVGFILWGTSLAALCYYFLYGHEFSQSVLFVMFETNAREAGEYFSQYFSLKLLLISLVYTAVSVFLWTRLRPVYIPLPWRRIVSFLLLYALLLHPVVLKSLIRQEPLNDTLGKLASRMEPAAPWQFVSSYYQYHQQLNALTTFLNENSALPPLGNLRDESGERPRTLVLVIGESTQRERMSLYGYLRETTPELDALRKTDPGLTVFNNVVASRPYTIEALQQALTFANEKNPDLYLTQPSLMNMMKQAGYKTFWITNQQTITARNTMLTVFSRQTDRQYYMNQQRTQSAREYDTNVLKPFREVLNDPAPKKLIIVHLLGTHIKYKYRYPEGQGRFDGITGHIPTGLNAKELEVYNDYDNANLFNDHVVASLIKDFRATAPDGFLLYFSDHGEEVYDTPPYKTQGRNEDNPTRPMYTVPFLLWTSEKWHAAHPRDFSQYVDRKYSLAELIHTWSDLAGLTYDGYDPTRSLVNPQFRETTRWIGNPYKKNGLTDFDTLPYGEP Kraken2_NZ_CP120945.1 IMICODJL_35543 Prodigal:2.6 34384 38286 - VFG000844(gb|WP_001034100) 100.0 0.0 (espP) autotransporter, serine protease VF0208 EspP VFC0086 Effector delivery system Encoded within the pO157 plasmid Serine protease; cleaves coagulation factor V MNKIYSLKYSHITGGLIAVSELSGRVSSRATGKKKHKRILALCFLGLLQSSYSFASQMDISNFYIRDYMDFAQNKGIFQAGATNIEIVKKDGSTLKLPEVPFPDFSPVANKGSTTSIGGAYSITATHNTKNHHSVATQNWGNSTYKQTDWNTSHPDFAVSRLDKFVVETRGATEGADISLSKQQALERYGVNYKGEKKLIAFRAGSGVVSVKKNGRITPFNEVSYKPEMLNGSFVHIDDWSGWLILTNNQFDEFNNIASQGDSGSALFVYDNQKKKWVVAGTVWGIYNYANGKNHAAYSKWNQTTIDNLKNKYSYNVDMSGAQVATIENGKLTGTGSDTTDIKNKDLIFTGGGDILLKSSFDNGAGGLVFNDKKTYRVNGDDFTFKGAGVDTRNGSTVEWNIRYDNKDNLHKIGDGTLDVRKTQNTNLKTGEGLVILGAEKTFNNIYITSGDGTVRLNAENALSGGEYNGIFFAKNGGTLDLNGYNQSFNKIAATDSGAVITNTSTKKSILSLNNTADYIYHGNINGNLDVLQHHETKKENRRLILDGGVDTTNDISLRNTQLSMQGHATEHAIYRDGAFSCSLPAPMRFLCGSDYVAGMQNTEADAVKQNGNAYKTNNAVSDLSQPDWETGTFRFGTLHLENSDFSVGRNANVIGDIQASKSNITIGDTTAYIDLHAGKNITGDGFGFRQNIVRGNSQGETLFTGGITAEDSTIVIKDKAKALFSNYVYLLNTKATIENGADVTTQSGMFSTSDISISGNLSMTGNPDKDNKFEPSIYLNDASYLLTDDSARLVAKNKASVVGDIHSTKSASIMFGHDESDLSQLSDRTSKGLALGLLGGFDVSYRGSVNAPSASATMNNTWWQLTGDSALKTLKSTNSMVYFTDSANNKKFHTLTVDELATSNSAYAMRTNLSESDKLEVKKHLSGENNILLVDFLQKPTPEKQLNIELVSAPKDTNENVFKASKQTIGFSDVTPVITTRETDDKITWSLTGYNTVANKEATRNAAALFSVDYKAFLNEVNNLNKRMGDLRDINGEAGAWARIMSGTGSASGGFSDNYTHVQVGVDKKHELDGLDLFTGFTVTHTDSSASADVFSGKTKSVGAGLYASAMFDSGAYIDLIGKYVHHDNEYTATFAGLGTRDYSTHSWYAGAEAGYRYHVTEDAWIEPQAELVYGSVSGKQFAWKDQGMHLSMKDKDYNPLIGRTGVDVGKSFSGKDWKVTARAGLGYQFDLLANGETVLRDASGEKRIKGEKDSRMLMSVGLNAEIRDNVRFGLEFEKSAFGKYNVDNAVNANFRYSF Kraken2_NZ_CP120945.1 IMICODJL_35546 Prodigal:2.6 39945 42155 - VFG001861(gb|WP_010945955) 62.1 0.0 (katA) catalase/(hydro)peroxidase VF0168 KatAB VFC0282 Stress survival A periplasmic catalase, expressed maximally during the post-exponential phase; important for intracellular survival and transmission MIKKTLPVLILLALSGSFSTAVAADKKETQNFYYPETLDLTPLRLHSPESNPWGADFDYATRFQQLDMEALKKDIKDLLTTSQDWWPADYGHYGPFFIRMAWHGAGTYRTYDGRGGASGGQQRFEPLNSWPDNVNLDKARRLLWPVKKKYGSSISWGDLMVLTGNVALESMGFKTLGFAGGREDDWESDLVYWGPDNKPLADNRDKNGKLQKPLAATQMGLIYVNPEGPGGKPDPLASAKDIREAFSRMAMDDEETVALIAGGHTFGKAHGAASPEKCIGAGPDGAPVEEQGLGWKNKCGTGNGKYTITSGLEGAWSTSPTQFTMQYLKNLYKYEWELHKSPAGAYQWKPKKAANIVQDAHDPSVLHPLMMFTTDIALKVDPEYKKITTRFLNDPKAFEQAFARAWFKLTHRDMGPAARYLGNEVPAESFIWQDPLPAADYTMIDGKDIKSLKEQVMDLGIPASELIKTAWASASTFRVTDYRGGNNGARIRLQPEINWEVNEPEKLKKVLASLTSLQREFNKKQSDGKKVSLADLIVLSGNAAIEDAARKAGVELEIPFTPGRTDASQEQTDVASFSVLEPTADGFRNYYSKSRSHISPVESLIDKASQLDLTVPEMTALLGGLRVMDINTNNSSLGVFTDTPGVLDNKFFVNLLDMSTRWSKADKEDTYNGFDRKTGALKWKASSVDLIFSSNPELRAVAEVYASDDARNKFIHDFVKSWNKVMNSDRFDLNNK Kraken2_NZ_CP120945.1 IMICODJL_35564 Prodigal:2.6 53554 63063 - VFG000845(gb|WP_000581721) 100.0 0.0 (toxB) cytotoxin VF0203 ToxB VFC0086 Effector delivery system A large 362-kDa protein encoded on the 93-kb plasmid that is present in O157:H7 and other EHEC strains; shares sequence similarity with the large Clostridium toxin family, and to the Efa-1/LifA protein Important for full expression of adherence by affecting the production and secretion of some virulence factors required for the development of A/E lesions MIHPGSSLDKAINNTRVKNVSTDVKHGQIQERKRNFIYKKNDDISSRFKLYSSLVKQKNATEDVVLIGKMILDEVRSYRTIHNDRNIVSNSGNWKTSFLCNLARLLYSIFNGSNYFCSREGENNSSPSSTLLTIHQPEKQELLQQKSIKHLPTSNNIDGYIKIRKTRGAEDQTTTITQSLIINELLNGVDRNTIPFQKISELNDIIHSYENMQIKNSRKGIEILVKQGELLSSLINDNKGNKQLSDNASKIINLLGIEYQSHKVDIEPFIHAVWVAGAPPDNTFSYITAFLNTYKDYTYLLWIDPNAFGAAKFSGILKNIAMNYAIMRLRRTNPHLAEEMNEVILKIQNIQNETIEFKETRERLKELENRYKSLTSETKEKFNVFFLESMIGMQDNYFTYCISNGISNTDDISRLDFLTNVLKLSPEVQNDFKSTVEKNKRDIDLLKNTISQKFGDRFQLRDINTLESFKKPQDYFFYQQEMLLRWNYAAASDQVRINILKEYGGIYTDTDILPAYSDKVSQIINEKSDDKRFFEDLKLRRIISESILSLIKGEKYSIKHDGLDETTLNQLNNILSEIEKLTIDDYFKPVETKVVRDTFKIFKRYQKWTENTWNIRGNNNFMLTHKGSKCIDFILSGQKKQYLELQRIRDNISYNNLFYTTEDLKSLNNVAIGGIPAKKYLEHGLFSEYRQDGTIPYVVSTLNISGPDMIMRQMKKYYKSLGRIGEVHIKDNKLSDVNFLGVYASSNKDNKSFNWLNPVSVGINDITPDDESSWAVRNNDINKILFEKINCHVPEKLPTSLYYEIDSRSFFQGWDNKSIKHVTEINKDLIKDINLLLTSSNIDVKLLIKLDRELYAISSKIDNPLALRSIRTLQLQLANYVTSNTFEPENTINFIYDFYRKKQDDLLSAIKLFSRNDADTKIIVWYNSVMEKNVFLREVISCVLRSKKVDSYINENKKNLSKEDAGALRDYAKLKMKELFSMLDDDGYKKIITTNAYIKERDKLSGIIYNIENSIISGHESFDIIRSNQHEWGDLSTVEQFKKFEFYVKSELSSAKSIFDDIKNKYITDPETKRNVLYHQLDSDIKERIAFLDISHYAYPGSLLEKLQLSGYVFSDINIIAEYLLASYGVSGHYSHGVVYPAPSDKLLELLRRHTKSNSEWIEKITPYVYDILSDNVSNVLRPPLSEEQKKILNDIKLEISKSVSEQYFMKLTEQKSSVIGIKYSVDFDRYNENLFLSLPINQNLTLPFMYRYFEMLYDIHIGIIENKANREFIYSKFSSLNLDFLINDERVLNLEGLIKKYKYLSLSEIHRTLTNSTSFADISIPLLQTICPSITTIIKKTEYYGHQLTNAMTVASVVKPYDFSNLGAINSIDKSVSDVPALHTIVEQAKYNLLSWNDFYNTHASIWDTIARQHKSTNIEFHPQSLLFDRDSKGKCLGLSLLYLDTGGYGGGYQKLRHNIDTASTLYQTKYNDNLKLSNRDDFFLRKTQRIITMSNELGNNRLKNAQLEVLELKDPILTEGILYQRRISSLLITTEYHSLALQQISSFWRVTDPNFGHCDFHSLAQALTFIKNITSNRNFSSLYGSGIVKIYFSESLNNWKYIKLPLVQTGSLLRDIYLTTPEKLSTSGGSLNIMGHLVPVSFIYDIGGVINGNRISESTDVKNKIRSLKINGDILQHYINTHYLSEEQTQKIKDIVDFLGIQDNTIKVKLESDIKPISEIQQPLHSILSRQKEHVKNLLSGLLDEFSNKLRKQGLSLKTNVLSVNNFKESKINSDTVEVTVTDLQGRLYRVDIDTRVIGLTFKEGINSLSEALEHMNIDAIMSVIGLVQYARMIKMNDNISAIDHAGAVSDIKNIVDKFLGGILTLTNNRVYNPGGVSGASLEGFISSGLEVCASRMGGTAGRYLSNVAKVIKLPLLDIGINIWSLYDSSLNHAKATTQIEYISTAIDVSFSSINTALSIGAIAYPPLAIAIVPITIFSHEVKNYAVYVNQINERHKLWLEAEKYLDNGSAKVLSINKATGIIDLSNNQVLGNIYLDMRENPPILHGEKSYNSGKNIGSHPDMTDREIMESRAYNFACTKLSDAGEPDIFGWGDKEICNSMELSESQLANGYSNRQWPSQIPVIPEGIYNTVYLGYGETLRANTEVTLSSTGYFYEIARAYTDDELSEPLLTVCNQHSHVIGGKEPLTIIIPAIEHGMLGSNLHMIERFKNYNFSISGGKGGIKLMVGGIGDYNIECTPGVRNIISFEQLSRDFNLDLDLSDGRKQNFNFHHPSGFYSGKVMSITQKGINAVVGTKLGYDKIRGNNLDNTFSLGSGGGVIYSGGGSNTYFVPATLQDNLHIYISEKSNGNHIILGDMHSRLSIECHFSNNEREFIKMGYYNGCDVILESDTIQKIKSFAKNITIQTADGVMANWDDKLNTLSVYSIDMIAWRDKNKTAKEPLPVDVIQLTNWRMHNTCSLFYDKYQVDIEANKLTYTVLFPDTELPVQLNYTSIIYGNHGAKYTFLNSGSKTIDIHILDKNSDYDTFDFRNIIFEHYTNEIFISFDNQGGFVISILNNATSEAANINVFRKNMTSLDSSGSLIYLPSGDIYHISDIYKMSRGRKSFKLNVEKKPDIDDIINVAILETSYLQIKKIPNNDDSDYILCLDNPNLSSYTLNFNDLSGYISSLWDNIRGSFTPFHKNTVNIAPNEKKYISLIGLDKLSFNIDVFRQALEVKNKNSYKISKFTWETYGDIVVSPEDRISHLELDGFNYFSQPELDTPISDSFSYLYDNFQIVDSDVHIKLLHLNRETKQITPHRIILKRYFIDSFAKTSITDREKNIYPVICDSPDHFTSDIYRHPFRIVLGNKTLYPSEELVKFISTSKEYLSNMDVINNVIVPQKTTKKNKLSIVSLNSNIKNDIVLSGVMTGTSKIFHLNNSGDLLLTTSKTHGGGVVVIFKDFINNWWKYNLTLITVPIDNKLSDNRINITPMGIKIQETVSGNDRLFFYPTPLKNGCFILHNPLYSNSFPSLYSHELFDLIEAYRNPTYSYLQNNIINRYIHTVSEYAGKDGIANMSLSIYAYSTCRFWSKESVAVGDTIKLSNYEHIEFSFNSFSKDYFREQNSDIYKIFFKIASSSNSVVVDKNTLTQKNFLENNTFFSITGIDESLYEKHIIFITLKVIVPSKK Kraken2_NZ_CP120951.1 IMICODJL_35770 Prodigal:2.6 26877 27584 - VFG002208(gb|WP_004681227) 60.0 4.36e-49 (virB1) type IV secretion system attachment mediating protein VirB1 Homolog VF0365 VirB type IV secretion system VFC0086 Effector delivery system Phagosome acidification is required for intracellular expression of the VirB type IV secretion system; the LuxR family regulator VjbR regulated the virB operon directly by bounding a fragment of the virB promoter containing an 18 bp palindromic motif The Brucella VirB type IV secretion apparatus is not required for early survival stages, like LPS or cyclic beta-1,2-glucan are, but rather for late Brucella containing vacuole (BCV) maturation events corresponding to sustained interaction and fusion with the endoplasmic reticulum (ER). Brucella initiates interactions with Sar1/COPII-dependent ERES (ER exit sites), the early secretory pathway. Unlike Legionella, that intercepts COPI-dependent vesicular trafficking from the ER for the biogenesis of its ER-derived replicative organelle; The acidified Brucella containing vacuole (BCV) interacts with late endosome/lysosomes, acquiring markers such as LAMP-1, CD63 and Rab7. Subsequently, wild-type Brucella is able to exclude these late endosomal/lysosomal markers from its vacuole and acquire markers of the endoplasmic reticulum. The replicative organelle contains not only the ER marker calreticulin, but also two proteins, Rab2 and GAPDH, that regulate membrane traffic between the ER and Vesicular Tubular Compartments (VTC), a compartment in the secretory pathway between ER and Golgi in which proteins are sorted either to an anterograde pathway to the Golgi, or for recycling to the ER. These components of the BCV are critical for the ability of Brucella to replicate intracellularly; VceA and VceC, also regulated by VjbR, are novel effectors, both require intact C termini for translocation through the VirB system MIAIDLPVLASTCAPAVHPVTLSAVVRNESGANPFAIGVVGGRLVRQPRTQAEAEATAAALERAGWNYSVGLAQVNRANFARYGLVGGAAFDPCANLRAGSEILADCYRRASIAAGPGQRALRHALSCYYSGNIQRGFKIEKDGTSYVQRVVAQASPQTQQSDAGKLTREPTSGNTATSADAPAAAVPAIAVVPDGAPARRVKRVTKGDAAAGAPSKGSGWDVFGDFGATKENRE Kraken2_NZ_CP120952.1 IMICODJL_35854 Prodigal:2.6 16348 18261 + VFG045768(gb|WP_012979416) 63.7 1.0199999999999999e-280 (lvhD4) type IV secretory system conjugative DNA transfer family protein VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MKIKMNNAVGPQVRTAKPKPSKLLPVLGAASMVGGLQAATQFFAHTFAYHATLGPNVGHVYAPWSILHWTYKWYSQYPDEIMKAGSMGMLVSTVGLLGVAVAKVVTSNSSKANEYLHGSARWAEKKDIQAAGLLPRERNVLEIVTGKAAPTATGVYVGGWQDKDGNFFYLRHSGPEHVLTYAPTRSGKGVGLVVPTLLSWGASSVITDLKGELWALTAGWRQKHAKNKVLRFEPASTSGGVCWNPLDEIRLGTEYEVGDVQNLATLIVDPDGKGLDSHWQKTAFALLVGVILHALYKAKDDGGTATLPSVDAMLADPNRDIGELWMEMATYGHVDGQNHHAIGSAARDMMDRPEEEAGSVLSTAKSYLALYRDPVVARNVSRSDFRIKQLMHEDDPVSLYIVTQPNDKARLRPLVRVMVNMIVRLLADKMDFEGGRPVAHYKHRLLMMLDEFPSLGKLEIMQESLAFVAGYGIKCYLICQDINQLKSRETGYGHDESITSNCHVQNAYPPNRVETAEHLSRLTGQTTVVKEQITTSGRRTAAMLGQVSRTYQEVQRPLLTPDECLRMPGPKKNAQGEIEEAGDMVIYVAGYPAIYGKQPLYFKDPVFSARAAIPAPKVSDRLRAVAQAETEGEGITI Kraken2_NZ_CP120952.1 IMICODJL_35884 Prodigal:2.6 44270 46828 - VFG045766(gb|WP_012979408) 67.3 0.0 (lvhB4) conjugal transfer protein TrbE VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MIEAIAIAIAVLGAVLLLILFARIRAVDAELKLKKHRAKDAGLADLLNYAAVVDDGVIVGKNGSFMAAWLYKGDDNASSTEEQREMVSFRINQALAGLGNGWMVHVDAVRRPAPNYSERGVSSFPDSVSFAIDEERRRLFEGLGAMFEGYFVLTVTWFPPVLAQRKFVELMFDDDAVAPDHTARTTGLIAQFKREITSLESRLSSAVKMTRLRGQKVVSEEGREVTHDDFLSWLQFCVTGLHHPVMLPSNPMYLDAVIGGQELWGGVVPKIGRKFIQVVAIEGFPLESTPGVLSALAELPSEYRWSSRFIFMDQHESLKHLDKFRKKWKQKIRGFFDQVFNTNTGSINQDAAAMVGDAEAAIAEVNSGLVAAGYYTSVVVLMDEDRERLAASALLVEKAVNRLAFAARIETINTLDAYLGSLPGHGVENVRRPLINTMNLADLLPTSSIWTGSATAPCPMYPPLSPALMHCVTVGATPFRLNLHVRDLGHTFMFGPTGAGKSTHLGIIAAQLRRYAGMSIYAFDKGMSMYPLAAGIRAATKGKSGLHFTVAADDDRLAFCPLQFLETKGDRAWAMEWIDTILALNGVNTTPAQRNEIGNAIMSMHASGARTLSEFSVTIQDEAIREAIKQYTVDGSMGHLLDAEEDGLSLSDFTVFEIEELMNLGEKFALPVLLYLFRRIERALKGQPSVIILDEAWLMLGHPAFRAKIREWLKVLRKANCLVLMATQSLSDAANSGILDVIVESTATKIFLPNVYARDEDTSALYRRMGLNARQIEILATAIPKRQYYYVSENGRRLYDLALGPMALAFVGASDKESVATIKSLEAKFGHEWVHEWLAGRGLNLNDYLEAA Kraken2_NZ_CP120952.1 IMICODJL_35887 Prodigal:2.6 47621 48583 - VFG045767(gb|WP_012979404) 71.9 8.22e-156 (lvhB11) P-type conjugative transfer ATPase TrbB VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MTDQKPEHNSIKERAKKKLERDMGPELLAALNDPKTVEIMLNADGKLWLERLGEPMKCIGTLRVAQAQAIIETIAGYHGKEVTRSKPILEGELPLDGSRFAGQLPPVVPAPTFAIRKKAVAIFTLDQYVERGIMTAPQREALIAAVRAHRNILVIGGTGSGKTTLVNAIINEMVIQDPTERVFIIEDTGEIQCAAENYVQYHTSIDVNMTALLKTTLRMRPDRILVGEVRGPEALDLLMAWNTGHEGGAATLHANNAKAGLDRLAMLISMHPDSPKPIEPLIGEAVHVVVHIARVEGSRRIQEILEVSGFANGQYITKTL Kraken2_NZ_CP066548.1 IMICODJL_38513 Prodigal:2.6 62345 63373 + VFG006022(gb|WP_002947383) 79.3 1.4200000000000001e-210 (rfbB) dTDP-glucose 4,6-dehydratase VF0144 Capsule VFC0258 Immune modulation Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages Resistant to complement deposition and masks cell wall-associated complement from being recognized by the complement receptors on phagocytes MENLLVTGGAGFIGSNFVHYVYNHHPEVKITILDKLTYAGNRANLEEILGDRVKLVVGDICDAPLVDELMQQTDVVVHYAAESHNDNSLKDPWPFIETNIIGTYTLIQSARKFNKRFHHVSTDEVYGDLPLREDLPGHGEGVGEKFTPTSRYKPSSPYSSSKASSDLLVRAWVRSFGLQATISNCSNNYGPYQYIEKFIPRQITNILSGIRPKLYGSGKNVRDWIHTNDHSAAVWDILNKGKIGETYLIGADGEMNNKDVLEMILELMGQPKDAYDVVKDRPGHDLRYAIDSTKLRTELGWQPEFTDFRSGLKATIDWYTDHQDWWQADKNKVESNYAKNGQ Kraken2_NZ_CP066548.1 IMICODJL_38525 Prodigal:2.6 73262 73930 + VFG016432(gb|WP_000059856) 60.6 1.56e-84 (BALH_RS26235) sugar transferase VF0659 Polysaccharide capsule VFC0258 Immune modulation MEYSGDNSKTIIIDPIVQRERYGYRLIKRLFDVCASFTALVLLSPMFLVVAIAIKAEDSQGKVFYSQIRVGKGGKRFKMYKFRSMVSNADELLKTLISENDVDGAMFKMKLDPRVTKVGSFIRKYSIDELPQLVNVLKGNMSLVGPRPPLEREVKEYTDYDKQRLYVKPGCTGLWQATVRNSVGFDEMVRLDLIYVQKRSLKFDLWIIFRTVKIMFRPNGAY Kraken2_NZ_CP066550.1 IMICODJL_38620 Prodigal:2.6 4511 5629 + VFG002182(gb|WP_002376666) 61.7 8.609999999999998e-176 (cpsI) UDP-galactopyranose mutase VF0361 Capsule VFC0258 Immune modulation The biosynthesis of capsular polysaccharides by E. faecalis is encoded by the csp operon, which includes 11 open reading frames (cpsA to cpsK). However, only 7 open reading frames in the cps operon are essential for capsule production (cpsC, cpsD, cpsE, cpsG, cpsI, cpsJ, and cpsK); Previous genetic evidence demonstrated that E. faecalis isolates can be classified in 1 of 3 capsule operon polymorphisms. CPS 1 presents only cpsA and cpsB. CPS 2 presents all 11 genes in the cps operon. CPS 5 presents all genes except for cpsF. Furthermore, CPS 2 and 5 express the capsular polysaccharide, whereas CPS 1 does not. Contributes to host immune evasion Masks bound C3 from detection on the surface of E. faecalis; masks lipoteichoic acid from detection MKAYDYLVVGAGLFGAVFAHEAALRGKKIKVIEKRDHIAGNIYTHEVDGIQVHQYGAHIFHTSDKQIWDYVNQFATFNRYTNSPVANYKGKMYNLPFNMNTFNELWGTKTPQEAMNKIAEQKSAAKITDQPKNLEEQAISLVGTDIYQKLVKGYTEKQWGQKATDLPAFIIRRLPVRYTYDNNYFNDTYQGIPIGGYTQIVEKMLDHPQIDVKTGVDFFDNKEKYLKDYPRVIFTGMIDQYFNYQLGELEYRSLRFESEELSVDNYQGNAVVNYTDAETPFTRIIEHKHFEFGKGDKNKTVITREYPVDWKRGDEPYYPVNNKRNNGLYKQYTELAKQEGNVVFGGRLGQYRYYDMHQVIHAALLAVEYELG Kraken2_NZ_CP068697.1 IMICODJL_38716 Prodigal:2.6 3790 4476 + VFG001445(gb|AAA92657) 73.9 3.05e-106 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MCPTDRRERTLASQSVNKYILSIQDIYKNSPVPVCVRNQSRKIIYANGAFIELFSKEDQPLSGDSYNRYGVEVFLSSLELECQSLGHGAAFCRRFNFHGEIYQIRMENISFDNNEIIVLWQINLFPDHPFFSPDTKTKNLSLSGTESFWNELSPGTLLVFSFYTLGVSHANIAKELGITIRASEDRIKPVKRKIKRNYESFDSFRISCISKGKIISLIDIIREFYCVK Kraken2_NZ_CP068697.1 IMICODJL_38761 Prodigal:2.6 41052 41609 - VFG000442(gb|NP_490501) 100.0 1.2600000000000001e-129 (rck) resistance to complement killing VF0108 Rck Resistance to complement killing VFC0258 Immune modulation Rck belongs to a family of five homologous OMP proteins characterized in Salmonella (Rck and PagC), Escherichia coli (Lom), Yersinia enterocolitica (Ail) and Enterobacter cloacae (OmpX) Rck is predicted to be an eight-stranded beta-barrel protein that resides in the outer membrane Confers serum resistance by binding human complement factor H.; Rck mediates cell invasion through a Zipper-like mechanism, as described for other bacteria such as Listeria and Yersinia. Salmonella seems to be the first bacterium found to be able to induce both Zipper-like mechanism and the Trigger mechanism mediated by its T3SS-1 apparatus. MKKIVLSSLLLSAAGLAAVPVAQADTHSVSVGYAQSRIEHFKDIRGVNLKYRYEAQTPLGLMASFSWQSGKRGESGGIPGGMSWRDDVKATYWSLMAGPAVRVNELVSLYALAGAGTGRAEVKERISMPGYNGRFTGSERRTGFAWGAGVQFNPVENVVIDLGYEGSKVGAAKLNGVNVGVGYRF Kraken2_NZ_CP068697.1 IMICODJL_38770 Prodigal:2.6 46308 47000 - VFG000433(gb|NP_490508) 100.0 8.61e-166 (pefD) plasmid-encoded fimbriae chaperone protein PefD VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MNKMMKWGLVSLLSLAVSGQAMAAFVLNGTRFIYEEGRKNTSFEVTNQADETFGGQVWIDNTTQGSSTVYMVPAPPFFKVRPKEKQIIRIMKTDSTLPSDRESLFWLNVQEIPPKPKASEGNVLAVAVNTKVKLIYRPKALVEGRRNAEKNLQIAHRGGEAYLKNPTPYYFAVTGVKLNGQPVRLNDRVMNEIAQLAPKSEVALGKLSLNGTVTVQAVNDWGGTQDYTLK Kraken2_NZ_CP068697.1 IMICODJL_38771 Prodigal:2.6 46993 49401 - VFG000434(gb|NP_490509) 100.0 0.0 (pefC) plasmid-encoded fimbriae usher protein PefC VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MSFHHRVFKLSALSLALFSHLSFASTDSELNLDFLQGMSAIPSVLKSGSDFPAGQYYVDVIVNQENVGKARLSITPQEESANALCLSPEWLKAAGVPVRLEGYASTLNAAGQCYVLSRNPYTRVDFSYGSQSLVFSIPQSFLVGKTDPSRWDYGVPAARLKYSANASQTSGQSTSAYANADLMVNLGRWVLASNMSASRYADGSGEFTARDITLSTAISQVQGDLLLGKSQTRSALFSDFGFYGAALRSNSNMLPWEARGYAPLITGVANSTSRVTISQNGYAVYSKVVPPGPYQLDDVRSVGNGDLVVTVEDASGHKTTTVYPVTTLPTLLRPGEVEYNVAVGRKSSNYKLKKPFADGENGMFWMGSVGYGFDSTTLNAASILHGKYQAGGVSVTQALGGFGAVSAGMNLSQAKYDNGDNKRGHSVSAKYAKSFSDSSDLQLLAYRYQSKGYVEFADFYSTDRYTRYNTKSRYEMRFSQRLGNSNLNLAGWQEDYWWMKGKAIGGDVSLSTTILDGVSVFLNGSYSKRPYLDKPDYSTSLSFSIPFTLGGVRHYSSTGLSYSSSGRMGMNSGVSASPTDRLSYGLNTNLSDKGDRSLSGNLSYGFDAIQTNMMLSQGRDNTTVSGSVSGTILGTADSGLMMTKETGNTLGVARIPGVKGVRINGSAPTNSKGYTVVNLSDYSLNRVSVDMENVPDDLELQTTSFNVVPTEKAVVYREFGAEHVLRYILRVKERDGRILNGGSAQTEQGLDAGFIAGNGVLLMNMLSAPSRVSVERGDGSVCHFSVKGIVPNTGKVQEVYCE Kraken2_NZ_CP068697.1 IMICODJL_38772 Prodigal:2.6 49629 50147 - VFG000435(gb|NP_490510) 100.0 5.8499999999999975e-115 (pefA) plasmid-encoded fimbriae major subunit PefA VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MKKSIIASIIALGVLGGTAHAANEVTFLGSVSATTCDLTTSVNGAAQPNQVVQLGTVQANQPGNFVDFAMKPVDPNAQGCANLAQKTATVSWASAALDGEGFGATSGTATDAKVLVESVNSKNPGAVNANASTVDFEGAKLTTDGLQFKAKLKGGATEGDFKSVASFAVAYK Kraken2_NZ_CP068697.1 IMICODJL_38773 Prodigal:2.6 50422 50724 - VFG000436(gb|NP_490511) 100.0 1.7499999999999999e-68 (pefB) plasmid-encoded fimbriae regulatory protein PefB VF0104 Pef Plasmid-encoded fimbriae VFC0001 Adherence Chaperone-usher assembly pathway Mediate binding of the bacteria to the microvilli of enterocytes MMLNRKDADYYLGKEIMLARIRRGALIPAKVNEEHFWLLIGISSIHSEKIIQALRDYLVFGVSRKDVCERYEVNNGYFSTSLNRLSRISQAAAQMVVYYS Kraken2_NZ_CP068697.1 IMICODJL_38791 Prodigal:2.6 62327 62977 - VFG000437(gb|NP_490527) 100.0 1.38e-155 (spvD) Salmonella plasmid virulence: hydrophilic protein VF0947 TTSS-2 secreted effectors VFC0086 Effector delivery system GogB; PipB; PipB2 (Directly binds kinesin, a plus end-directed microtubule motor protein. Localizes to the phagosome; Promotes Sif extension, recuits kinesin-1 to SCV. ); SifA (GEF. Localizes to the cytosolic face of the SCV and binds to host protein-kinesin-binding protein SKIP to modulate phagosome tubulation; required for SCV membrane integrity and Sif formation; maintains perinuclear SCV positioning; redirects exocytic vesicles to SCV. ); SifB (GEF, WxxxE family. ); SopD2 (Inhibits vesicle transport from the vacuole; down-modulates the formation of tubular structures. ); SpiC/ssaB (SsaL/ssaM/spiC regulatory complex, sensing host cell signals to activate effector secretion. ); SpvB (ADP-ribosyltransferase. Causes cytoskeletal disruption and apoptosis. ); SpvC; SpvD; SseF (Localizes to the phagosome, contributes to Sif formation; recruits dynein to SCV; maintains perinuclear SCV positioning; required for formation of microtubule bundles around SCV; redirects exocytic transport vesicles to SCV. ); SseG (Same as SseF. ); SseI/srfH (Blocks the migration of host immune cells by associating with host protein IQGAP1, an important regulator of cell migration; attenuates the host's ability to clear systemic bacteria. ); SseJ (Glycerophospholipid-cholesterol acyl transferase and deacylase. SseJ and SifA interact in a protein complex with SKIP and RhoA family GTPases as a mechanism to promote phagosome tubulation. ); SseK1; SseK2; SseL (Deubiquitinase. Required for Salmonella-induced delayed cytotoxicity of macrophages. ); SspH2 (Novel E3 ubiquitin-ligase. Specifically localizes to the brush border of polorized epithelial cells. ); SteC (Serine/Threonine kinase. Required for SPI-2 dependent F-actin remodelling. ) MRVSGSASSQDIISRINSKNINNNDSNEVKRIKDALCIESKERILYPQNLSRDNLKQMARYVNNTYVHYSGNCVLLSACLHYNIHHRQDILSSKNTASPTVGLDSAIVDKIIFGHELNQSYCLNSIDEVEKEILNRYDIKRESSFIISAENYIAPIIGECRHDFNAVVICEYDKKPYVQFIDSWKTSNILPSLQEIKKHFSSSGEFYVRAYDEKHD Kraken2_NZ_CP068697.1 IMICODJL_38792 Prodigal:2.6 63238 63963 - VFG000438(gb|NP_490528) 99.6 3.65e-177 (spvC) type III secretion system effector SpvC, phosphothreonine lyase VF0947 TTSS-2 secreted effectors VFC0086 Effector delivery system GogB; PipB; PipB2 (Directly binds kinesin, a plus end-directed microtubule motor protein. Localizes to the phagosome; Promotes Sif extension, recuits kinesin-1 to SCV. ); SifA (GEF. Localizes to the cytosolic face of the SCV and binds to host protein-kinesin-binding protein SKIP to modulate phagosome tubulation; required for SCV membrane integrity and Sif formation; maintains perinuclear SCV positioning; redirects exocytic vesicles to SCV. ); SifB (GEF, WxxxE family. ); SopD2 (Inhibits vesicle transport from the vacuole; down-modulates the formation of tubular structures. ); SpiC/ssaB (SsaL/ssaM/spiC regulatory complex, sensing host cell signals to activate effector secretion. ); SpvB (ADP-ribosyltransferase. Causes cytoskeletal disruption and apoptosis. ); SpvC; SpvD; SseF (Localizes to the phagosome, contributes to Sif formation; recruits dynein to SCV; maintains perinuclear SCV positioning; required for formation of microtubule bundles around SCV; redirects exocytic transport vesicles to SCV. ); SseG (Same as SseF. ); SseI/srfH (Blocks the migration of host immune cells by associating with host protein IQGAP1, an important regulator of cell migration; attenuates the host's ability to clear systemic bacteria. ); SseJ (Glycerophospholipid-cholesterol acyl transferase and deacylase. SseJ and SifA interact in a protein complex with SKIP and RhoA family GTPases as a mechanism to promote phagosome tubulation. ); SseK1; SseK2; SseL (Deubiquitinase. Required for Salmonella-induced delayed cytotoxicity of macrophages. ); SspH2 (Novel E3 ubiquitin-ligase. Specifically localizes to the brush border of polorized epithelial cells. ); SteC (Serine/Threonine kinase. Required for SPI-2 dependent F-actin remodelling. ) MPINRPNLNLNIPPLNIVAAYDGAEIQSTNKHLKNNFNSLHNQMRKMPVSHFKEALDVPDYSGMRQSGFFAMSQGFQLNNHGYDVFIHARRESPQSQGKFAGDKFHISVLRDMVPQAFQALSGLLFSEDSPVDKWKVTDMEKVVQQARVSLGAQFTLYIKPDQENSQYSASFLHKTRQFIECLESRLSENGVISGQCPESDVHPENWKYLSYRNELRSGRDGGEMQRQALREEPFYRLMTE Kraken2_NZ_CP068697.1 IMICODJL_38793 Prodigal:2.6 64244 66019 - VFG000439(gb|NP_490529) 100.0 0.0 (spvB) type III secretion system effector SpvB, ADP-ribosylation activity VF0107 SpvB VFC0235 Exotoxin PDB accession: 2GWL SpvB-mediated actin depolymerization is associated with an accumulation of cells in the G2/M phase, eventually resulting in apoptotic cell death An ADP-ribosylating toxin that modifies actin directly and totally disrupt the cytoskeleton of the cell MLILNGFSSATLALITPPFLPKGGKALSQSGPDGLASITLPLPISAERGFAPALALHYSSGGGNGPFGVGWSCATMSIARRTSHGVPQYNDSDEFLGPDGEVLVQTLSTGDAPNPVTCFAYGDVSFPQSYTVTRYQPRTESSFYRLEYWVGNSNGDDFWLLHDSNGILHLLGKTAAARLSDPQAASHTAQWLVEESVTPAGEHIYYSYLAENGDNVDLNGNEAGRDRSAMRYLSKVQYGNATPAADLYLWTSATPAVQWLFTLVFDYGERGVDPQVPPAFTAQNSWLARQDPFSLYNYGFEIRLHRLCRQVLMFHHFPDELGEADTLVSRLLLEYDENPILTQLCAARTLAYEGDGYRRAPVNNMMPPPPPPPMMGGNSSRPKSKWAIVEESKQIQALRYYSAQGYSVINKYLRGDDYPETQAKETLLSRDYLSTNEPSDEEFKNAMSVYINDIAEGLSSLPETDHRVVYRGLKLDKPALSDVLKEYTTIGNIIIDKAFMSTSPDKAWINDTILNIYLEKGHKGRILGDVAHFKGEAEMLFPPNTKLKIESIVNCGSQDFASQLSKLRLSDDATADTNRIKRIINMRVLNS Kraken2_NZ_CP068697.1 IMICODJL_38803 Prodigal:2.6 73581 74321 - VFG002301(gb|NP_490536) 100.0 2.74e-170 (mig-5) putative carbonic anhydrase VF0396 Mig-5 Macrophage-inducible gene-5 VFC0325 Antimicrobial activity/Competitive advantage Mig-5 was found to be expressed by Salmonella when ingested by macrophages. mig-5 codes for the carbonic anhydrase which catalyses the hydratation of carbon dioxide and formation of HCO3-. The biological meaning of this reaction in intracellularilly residing of Salmonella is, however, not known. MEQNQPAQPSRRAILKQTLAVSALSVTGLAALSVPTISFAASLSKEERDGMTPDAVIEHFKQGNLRFRENRPAKHDYLAQKRNSIAGQYPAAVILSCIDSRAPAEIVLDAGIGETFNSRVAGNISNRDMLGSMEFACAVAGAKVVLVIGHTRCGAVRCAIDNAELGNLTGLLDEIKPAIAKTEYSGERKGSNYDFVDAVARKNVELTIENIRKNSPVLKQLEDEKKIKIVGSMYHLTGGKVEFFEV Kraken2_NZ_CP077849.1 IMICODJL_39024 Prodigal:2.6 4712 5785 - VFG013612(gb|WP_011609686) 65.9 6.500000000000002e-168 (hemE) uroporphyrinogen decarboxylase VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MTTLKNDRFLRALLREPVDTTPIWMMRQAGRYLPEYRETRSKAGDFLSLCKNTEFACEVTLQPLRRYDLDAAILFSDILTIPDALGLGLYFETGEGPKFHKTVRTEQDVANLPKLNAKADLDYVMNAVSTIRSALGGQVPLIGFSGSPWTLATYMVEGGSSKEFRFTKQMMYAQPEVLHALLDHLADSVIDYLNAQIDAGAQAIQIFDSWGGALAHREYVEFSLNYMNKIIAGLQREKDGRRIPVIVFTKGGGQWLEPMIASGADALGLDWTTPLNTARNVVSGRVALQGNLDPAVLYGSAASIEKAVKAMLDDAYANGEKTGYVANLGHGITQWVDPAQPKIFVDTVHEYSAKYLG Kraken2_NZ_CP077849.1 IMICODJL_39026 Prodigal:2.6 7453 8622 - VFG037218(gb|WP_000983821) 100.0 3.65e-281 (basJ) acinetobactin biosynthesis protein BasJ VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MMQTQISVEQNLDHIGQKKFSCFSTKNYYLEVNEFVKTLNTPAANTALLNEEIAKCFEEIKKQGHQNPVLIGAIPFDITKKSSLNFYADHKKITQSSSTINSLKNRNNIEIINKSLLIQRQKFEGTVQLALDAFEKKKVEKVVLSQAVEYEFNRHQEPENLLAALLKQNPNAYNFVIPVEHNNYILGASPELLLSKQGRIVTSNPLAGSRPKSQISEKNFVSQQELNHSEKDQHEHRIVVENIIRNLATHCVELKVSEFPDILETSTMLHLSSEFQGVLKQQAPDALNLALELHPTPAVCGSPTHVAKQFILDHEGYDRHYYTGLVGWMDAEGNGEWVVTIRCGLLSENKMRLYAGAGIVEGSDAEAEWLETEAKMQTMLNILNTKVAV Kraken2_NZ_CP077849.1 IMICODJL_39027 Prodigal:2.6 8747 9502 - VFG037232(gb|WP_001093095) 100.0 1e-179 (basI) phosphopantetheinyl transferase component of acinetobactin biosynthesis protein BasI VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MNTKKQLSRGANSCLDEINIQYEKLTAFGIDIHKVQLSEIKEIPQLDHIYQELNIFLPPNIKSSRFIRQLEFLTGRLAAKYALQRFNLQDSIVHQGKQGEPLWPEGVMGGISHVGSKKSCHAIAYVRNNTLKEKIFGIDIESQKHHIFFQKKDEFYDVFLNKNEQAEIEKLLKDQAYLYLVIFSAKESIIKAFYLKYKQIIDFKNIKFKALDGAFLYFYLRQESLIEITLEVKVYFFHTNNEIITISCIEN Kraken2_NZ_CP077849.1 IMICODJL_39028 Prodigal:2.6 9513 10247 - VFG037246(gb|WP_001032906) 100.0 7.710000000000001e-185 (basH) non-ribosomal peptide biosynthesis thioesterase BasH VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MNKHQYNMFCLPPAGSSASIYHPWKKQISDNIRIIPIEYSGHGIKINEPLIDDPDLLAMQIANEIQAYSDTPFILFGHSVGGGLIWKVLNYLNEKPIIDQLRLIVISSRPEHHYIQHMRYKHELTDEKIIDELKRYNNFPDEILNNQEALTFFLKIIRNDFYLSDQLLSEKIHKTEVPIVAFYGKQDPDIPNKRMMDAWQQHTENWLGSIEFEGDHFYFLNPETRVKMLENIAAIVETLTVNIE Kraken2_NZ_CP077849.1 IMICODJL_39029 Prodigal:2.6 10320 11915 - VFG037260(gb|WP_001095752) 100.0 0.0 (barB) siderophore efflux system of the ABC superfamily VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MNTPAKLNKDQIFSMLPRAAKQKLIIVGIGWIIVAAIEAIAYTVLAFAIVNQWSPSWVLISAIAAILVTVIVTRAGFLTGVRLAGDLFAELGKSLARAKLSWFTNEQRAQIKTIAGQGIPGFMSIPAHQLQTFLHAPFMPLFLTIGIGLLAGAGVAFVALGLLLLSLFAQFLAQRALMHIDKKRNTADLAASQATLELVDHVELLRTAAGPERAVQRLEHRWEEQEETLVRINRAAAFASFIATLASVLPIAGMATYLVIDGVNHAALVLALLVLIGRAAAPLGELATAGLHINDLFAALRNFNQITHPPELPEPLHPQIPTGHHISVQDVSYAPALENISLDIALGSRVWVTGPSGSGKSTLLELLTRFDDPQRGKITLGGIALDQMKYEDLVSNIAYVTQEPILFTSTLAENIRLGKPDATDDEIEKAARDAALGAMIDRSSEGINQSVGKQGTALSGGERQRVAIARALLKNAPILILDEATSALDEETEQEIVTTIRALSSTVIFVTHRDSAIWQPTQTINLASTSV Kraken2_NZ_CP077849.1 IMICODJL_39030 Prodigal:2.6 11912 13522 - VFG037274(gb|WP_001281538) 100.0 0.0 (barA) siderophore efflux system of the ABC superfamily VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MSDLKLSHLMTDSSLAPALKPAFPKLFAGTLAAVFSGLAILTALWGMIQLIGYLSSYWVIFSAVFWIVGAALAALASWLVHDAEAGFSARLRRQIAHHLIRLPNTTLSKQGDQNLKRLVSDDIATLHHMVAHLPSEIAIFAVIPLVSIILLIALVGPMALWVLLPGAIASLYYLIIVPHVSKRDGAARMQVMLDIIGSADDYARGIRDNRIYGQQSGALTAYIQSAQNFTQNMVSWVSKVATLAAVATALLQAVATFAIAYFVAYQYDSMTLAATLFFSLAIVTPSLRLGHGLDYVAAGRAAASRLSAFLKEPVLSSGNLQKIEQDVTLEIVNASFAIENQKVLDRLSYAFPKNSITAITGPSGVGKTTLLRALAGFAVLQEGVVQLAKTDILQLHEKLRHEKVLFIPQGGDVLPTTVRENLSLSAVNANDAQLEQALLKAQLKVDLNADATLLSGGEKQRLGIARAFLSSAPIILLDEPTSALDQTNATKIILELSDLAKKQNKTIVMVTHDLALAAHADSRLVLKGPTDSGKSL Kraken2_NZ_CP077849.1 IMICODJL_39032 Prodigal:2.6 13767 14918 - VFG037288(gb|WP_000603876) 100.0 1.1999999999999998e-292 (basG) acinetobactin biosynthesis protein BasF VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MILSPADQERIETFWNYCLKHQYFNIGYPESADFDYSALFRFFKFSINNCGDWKDYSNYALNSFDFEKDVMAYFAEIFQIPFEESWGYVTNGGTEGNMFGCYLARELFPDSTLYYSKDTHYSVRKIAKLLQMKSCVIESLDNGEIDYDDLIHKIKTNKESHPIIFANIGTTMTGAIDDIEMIQERLAQIGIMRRDYYIHADAALSGMILPFVDHPQAFSFAHGIDSICVSGHKMIGSPIPCGIVVAKRQNVERISVDVDYISTRDQTISGSRNGHTVLLMWAAIRSQTNLQRRQRIQHCLKMAQYAVDRFQAVGIPAWRNPNSITVVFPCPSEHIWKKHYLATSGNMAHLITTAHHRDTRQIDSLIDDVIFDLQGASKRTVGF Kraken2_NZ_CP077849.1 IMICODJL_39033 Prodigal:2.6 15036 15905 - VFG037302(gb|WP_001018264) 100.0 1.1500000000000002e-213 (basF) aryl carrier protein BasF VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MAISKISTYLMPERESYPNNKTDWQLDPSRAVLLIHDMQRYFLNFYDAESELIKTVVNHLVQLRTWAHQNNVPVVYTAQPYEQPAADRALLNAMWGPGLPASTIDQQKIIDQLSPAEHDIVLTKWRYSAFKRSDLLERMQNWNRDQLIIGGVYAHIGCMVTAIEAFMSDIQPFLVGDAVADFSEEEHRLALKYVSSRCGQVVDTESVVGQVATGITRPWLEQKVQQLIEEDELDPEENLILYGLDSLRIMQFSSELKAQGINISFEELGRTPTLSNWWSLVDARQRIAG Kraken2_NZ_CP077849.1 IMICODJL_39034 Prodigal:2.6 15923 17551 - VFG037316(gb|WP_000744381) 100.0 0.0 (entE) non-ribosomal peptide synthetase adenylate-forming enzyme of acinetobactin synthesis VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MKKQLIEFVRWSPERAQHYRNKGYWIDQPLTRILTVGVQSHPHSPAIICGERQLSYIELDRLSTNLASRLAEKGLGKGDTALVQLPNVAEFYIVFFALLKAGVVVLNALYSHRQYELNAFIKQIQPKLLIGSRQHEVFSNNQFIDSLHEVNLSPEIILMLNHQATDFGLLDWIETPAETLVDFSSTPADEVAFFQLSGGSTGTPKLIPRTHNDYDYSVRASAEICDLNSNTRLLCALPAPHNFMLSSPGALGVLHAGGCVVMAPNPEPLNCFSIIQRHQVNMASLVPSAVIMWLEKAAQYKDQIQSLKLLQVGGASFPESLARQVPEVINCKLQQVFGMAEGLVNYTRLDDSDEQIFTTQGRPISSDDEIKIVDEQYKEVPEGEIGMLATRGPYTFCGYYQSPEHNSQVFDEDNYYYSGDLVQRTPDGNLRVVGRIKDQINRGGEKIASEEIEKLILLHPEVMHAALVAIVDEQFGEKSCAFIVSRNPELKAVVLRRHLMELGIAQYKLPDQIKLIESLPLTAVGKVDKKQLRSILNTSTTS Kraken2_NZ_CP077849.1 IMICODJL_39035 Prodigal:2.6 17788 20655 + VFG037330(gb|WP_001177743) 100.0 0.0 (basD) acinetobactin biosynthesis protein BasD VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MCELTSMQAACWFGRSGNATLGGVAAHLYAEFDGQFIDLQKLHLALQRLYKEHPILRLSLSADGIANIMSEKTQQILEVDDFSKLSDYQIEQMLMQKREQWTHQKLDLSQGQTARFSISVLKNNIFRFHIDTDMIAIDPSSFLNLMEDLSLFYEDPEISFSRPPNFFDWYQKIRTDPDLKKLSQRDRLWWKQRLSHISPAPSLPFIHQEFKTAKSDRLSTWLSPKERTALQQLARKQHITVTNLILGLFAYTLGHATKDHSFRLNIPTFWREPVLKNVEGTIGDFANLVILDVDMKGTTTLAAFCKQIANQMLELLEHSHYSGVNVLRDLSRYHGSAQIAPVVFTAALDLENNNLLSEHVRRVFGSMNWVISQGPQVALDAQVAHVDDGILVNWDIRLDALPKEWITNLFESFIHLLKNLAAHPEQLNTQIISPAQNTSSDRTSQKPLNALQQAYLLGRTQALPLGGVAMQEFRQYHGKMDIVLLRQRLAEMVRQHDSLRTYIDKNRLIQYISDQVSVNLKEIDLTTWEPERASHHIQSYKNSYTHELFDLNQSPWNITVFLLKNNLLTIFVRFDALILDGRSIASLMLELFDGQQHDIQTQIEENEAENSLSVHHTDMAYWERKFSKLSAIPAFPWKTPLQHLPTSRYQRKSLVIEKDQFKQLSKIGAKHSLFKNSIIMAIILEVLSHWSTDKSLCVAVPTLPLYAGPFSNSSTFIAVEWKTSDQFAEQANRLQTEVLEGLQHLSFSGVDLARLLFEKVGTAPVLPIVITNGLSWPVLSESHPIQQLDGLTQTPQVAIDIRFSTRNDGALIFDIDYAQEAFPPNMIDDFLDALQLAIKQIIGSEIFSFDLSNFFSELQNKRLYFKNNESDHSSIPIENNAKQQNQLLDIYLEVIGHPPNMEVDNSTHFTHLGLRPHHLKVVSKRINETYAIQLSPVQLIQCRNIADVEKLVTPH Kraken2_NZ_CP077849.1 IMICODJL_39036 Prodigal:2.6 20703 22013 + VFG037344(gb|WP_000717759) 100.0 0.0 (basC) acinetobactin biosynthesis protein BasC VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MKKIDITGIGIGPFNLGLAALLSHHPEIKSVFLERKPEFRWHEGLLLQGTTLQVPFFADLVTMANPCHPLGYINYLHQHDRLHQFYYYDSFLIPRREYDHYCRWASKQLPDCRFGENVSHVEYDAKLDKFIIESESASGEKQKYISQNLAIGIGTKPRIPKWLETCKHPLVKHSAEFAKIQEQLKQCKQVTVIGSGQSAAECVLALFNSLTPEQVKAGASIRWITRSAGFHPMEYSKLGQECFTPAYMQYFQSLPRDKRRDIAASQGLIYKGISFSTIGDIYDVLYERSVAGEKSGLSLYTSCEVESVKELESGSLRLTCLHTQLDQRCELETDALVAATGYVHDWPEWFQNMKGSILAVDDKNDCIVQEDFTALRCDQGQGRIFIQNAEIFQQGVGSPDLGIGATRNSVIINQLLGRNAYRIPKQSSFQHYGLPE Kraken2_NZ_CP077849.1 IMICODJL_39037 Prodigal:2.6 22079 24334 - VFG037358(gb|WP_001073030) 100.0 0.0 (bauA) TonB-dependent siderophore receptor BauA VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MNNVSYNRNFKTGNDQRINHRSFVLNGVASAQIALRLGYALGTVFVLCASNTYAAVIDNSAKTLEQQTAQTNVAALPAITVKAEQDDTYAGGQVSSKSSVGFLGNKTVMETPFNTIAYTDTYIADKQAKDITSVIAKTDPSVFTNAASGGWSENYYIRGFESSPSDMSMNGLFGITPYYRTSPEMFEKINVLKGPSALLNGMPPTGSIGGTVDLTTKRATDEPLTRLTTTYMSDSQFGGHLDVGRRFGSDKEFGVRANAVYRDGSGPVEKQDLKTELFSLGMDWHGDRARVSTDLYTSKDRVDGVTRGINLGKDIAIPKPPKPETLLNPDWSFVDIQDKGAMIRGEYDLTNNVMGYATYGQSKTEYKYNGAMSATVLDNTGTFQTSIGQLAFNVDKKSADVGLKGKFNTGAVGHQWVVNATYYKHNQDDYGVRNVAGAEWTTNLYDPIWGKAVPFNAPLISNSELQLNSYGLADTLSFIEDRLQLTLGVRYQEVESSNLFVPTSTLTKYKKNATTPGAAILFKATDKVSIYANYIEGLTKGDAAPLTAANYPTIFAPYKTKQTEFGVKFDQGTFAHTLSLFEIKKPSAYTDLVTNIYTSGGEQRNRGIEWSFFGSPIENVRLMGGASYIEPEVTKTAIQSNEGNMAVGVPKTQGKLGVEWDNEVAQGVLTLSSNATAVSKQYIDQENTLHIPGRTLIDVGARYKTSISNHPITFKADINNLMNKAYWGMPKLSNLALGAPRTYMLSVSYDF Kraken2_NZ_CP077849.1 IMICODJL_39038 Prodigal:2.6 24447 25415 - VFG037372(gb|WP_001104139) 100.0 1.9499999999999998e-233 (bauB) ferric siderophore ABC transporter, periplasmic siderophore-binding protein VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MNWKKKYGGVALIIAAAVTLQACDQKVADTTQASQKLAEPITVKHALGTTVINHLPQRVAVLDMNEADFLDQLNVPIMGMPKDYVPHFLEKYKKDAQIQDLGAIVQPNMERIYALKPDLILMTPLHVNHYQELSKIAPTIHYDINFNNSESNHIGLVKDHMMTLGKIFNKEDLARQKVSELDEQVKQVQAVTANRPERALVVLHNNGAFSNFGIQSRYGFIFNAFGVKPASGVVDTSLHGQPISSEFIKKADPDILYIVDRTAVMEHRSNINAASVENPLLRQTKAWKNGRVIFVDADAWYTTAASPTSLKIVMEDVKKGYQ Kraken2_NZ_CP077849.1 IMICODJL_39039 Prodigal:2.6 25422 26192 - VFG037386(gb|WP_000582115) 100.0 5.8299999999999995e-186 (bauE) ferric siderophore ABC transporter, ATP-binding protein BauE VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MIHVKNINKSYGNKPILTDVNVEFPTGQVTSLIGPNGAGKSTLLMMMARLIEPDKGEIFLNHQNIADIKTAVYAKHVATLRQAPGFNLRLTVEELVSFGRFPYSRGVLTEQDHQVVDEAIEFLSLEPLRKSYIDEISGGQRQMAFLAMTIAQQTDVLLLDEPLNNLDMKHAVQIMRALRRLCDEQGRTVILVIHDINFATNYSDHIVALKNGKLHFSGLTEQVITEAQLNDLYELDFEITYSERGCMCNYFNSSGA Kraken2_NZ_CP077849.1 IMICODJL_39040 Prodigal:2.6 26189 27136 - VFG037400(gb|WP_001223274) 100.0 1.63e-217 (bauC) ferric siderophore ABC transporter, permease protein BauC VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MRITKLWMIYLIVICLAVCFLFLNSGLDFDYVIPNRLLRLATIVIAGICVAFSSIVFQTLVGNRILTPSIMGYEAIYLLWQVLLLFFWGTHGLSQLGINGNFFISIVLMLLYSWVIHKWLLPYGRNDVFLLLLLGLVLTMVVGTVTQFIQLKINPGEFSVFQGLSYASFNRSQPETLFYASVAVVIVLFLGRKALPVLDVLVLGREQAISLGIHHHRYVSFYLALIAILVAVSTSLIGPTVFMGVFIANITYALARSYKHKLTLPMGCAITIAIFIAAQILVEHVFNYKTTVSILVNLVCGIYFLALTVRTRGVA Kraken2_NZ_CP077849.1 IMICODJL_39041 Prodigal:2.6 27136 28077 - VFG037411(gb|WP_001210787) 100.0 4.7800000000000004e-209 (bauD) ferric siderophore ABC transporter, permease protein BauD VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MRFGLFCIFIILCICSLLLGAEQIQWSTLFSFSHESWLTLTASRIPRLITIVLTGIGLAVCGVILQHIVRNKFVEPETSGGLDAAKLGILVSLTLVPVTSTLSKMIFAIIFCFIASLIYIAIIRRIRFRNMVLVPVIGLMYGSVLSALAEFYAYRFNILQSMQGWLLGDFSKIVQGHYEVIYIIFPIVVLTYLFAHRFTVIGMGEEMASSLGLSYAAIAAIGLILVAITVSTTVITVGAIPFVGLVVPNLVALKYGENLAKTLPIVALGGASLLLICDILGRSIIYPFEVPIGLTAGGVGGIIFLILILREFR Kraken2_NZ_CP077849.1 IMICODJL_39042 Prodigal:2.6 28643 30739 + VFG037428(gb|WP_000939834) 100.0 0.0 (basB) non-ribosomal peptide synthetase with condensation and peptidyl carrier protein domains VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MLEQFSKSPSLLSVTDYEEHIWMLQLQQPEQVNRRFNLWKLNQDLDIQLLIKAIQDIIKTTPDLNVRYTFSVEGDLYKYPFDDHSACLEVKKSNTEHVFEQVNTLKAQAWNAEFHPPFFTSLVETEQDYFLILALHPILDESYQKSDFIQTIQNRYQQYSPHNMPLVLTEIDISNQLDANSTKASEQSNQNYVSEIILEEFRNTLAEPEMSQHDDFFDFGGHSLLATRIIGNLLNKHGIEIQFNDFFKSPSAADLAQYALVKSAKTEKTTLQSVDQAPLTLAQDFLWQAYSAFDFSPIYNLPFAVEFLEEINEDVFFQAFTDIVERHAGLRTIFNSANGQTYQQVIPTSELQQFKWFWNSAESKDATLASEASYKFDLTRELPLRIRLIRNAKGRQTLSFLVHHMVIDEWSLNTIMADLAHAYLARSNAQAPNWKAPAQSILDFSLLQQKQGINQDHLNYWTNLLRGATKGLNLPVSEHELNAEKEKPPVQWLELKFAPEMHEKLLAFSRQHSSSIFTVLYTAIAHALQQQGNLKDIVIGTSASGRTDPEFFDTVGYFTTMVAHRTQFSPSDSFQSLLHNISTMINTSMAYADIPINHIQNALGMRADEGLLFDVFIHIHSNNALNGALKTPQGQNLPYRQILPERDESMFGLHFEIMENVIDGQHQLSMIITYQAHRFPTATVQSICEKIKATLAQI Kraken2_NZ_CP077849.1 IMICODJL_39043 Prodigal:2.6 30810 32657 - VFG037442(gb|WP_000910253) 100.0 0.0 (basA) acinetobactin biosynthesis protein VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MLKDLSQNLGQMNDKNNNVENFLKQIYENIFDQNSNRTALIFENRSISYAEVGTQVAKVMYALKMQDLATGSVVAICLRKSPEHIYTALACALTGIIWLPVDMDSPPSRLNYLLTNSRADVVVSDSSIAGVQTLNINEILSATTEYEPSFNAEINRLPAYYLYTSGSTGTPKCVVLNNQATENTLQQTISEWKITADDVIMAVTPFHHDMSVFDVFASMAVGATLVVPSFEQSKNAVVWADLVDRCKVTIWSSVPAIVDMLFSVAQKEQLQSLRLIAQGGDYIKPSLITKLRQQLLNARLFSLGGPTETTIWSIWHEINEQDQEIIPYGKALENNQYFILDENLKPCQMGEVGTMYMTGLNLSNGYLLDGEINYKDFVDIQVSENETQTAFRMSDQGYFREDGNIIFAGREEGYLKIKGVRISAAEVENALTKHPYIHNCVVVSCVHPTTETQELVAVYTLENKYKTTRLNSPELKNFLKVHLPSSHIPSKYLSIETIPLTRNGKIDRKAVQEIAQEKIYVSSTLSANSTKTLSSVAELGDSVLSIFRECIADSQAEKMDIFYRSEILAIGIRPKQLMSIAQKLSQKLNTQIDFYTLISCKTIQDVVNKVEQQIK Kraken2_NZ_CP077849.1 IMICODJL_39044 Prodigal:2.6 33050 33910 + VFG037456(gb|WP_000160878) 100.0 1.19e-209 (bauF) siderophore-interacting protein VF0467 Acinetobactin VFC0272 Nutritional/Metabolic factor An iron-chelating molecule composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine High-affinity catechol-hydroxamate siderophore competing with host cells for iron MTKIAEKSKQEYGDLLKEKDHLQDMEQLEMTIVSIQTPYPSIVRIQGKINTLQPELWQAPNLAIRLIVNNPPEGQPISRVYTVRSFNPVNAQIEIDFVKHEDLSPAMEWLNSAQVGTKIGLIGPRPHFIPNFTAKKHVVMFADDTAVPALYSILKQWELGISADIFIESFEKDIASQLPELEHVKIHSFHKEHHTAQKGLLLKAAFALENYENITIWAACERNEARALRQFFLEDQHLNKNDVRIAGYWRDGVSSSELDKLRAQHYQEHIQQGKTLNEYDDLDLAN Kraken2_NZ_CP077849.1 IMICODJL_39114 Prodigal:2.6 113046 114419 - VFG044201(gb|WP_011267793) 72.2 1.95e-232 (PSYR_RS13390) diaminobutyrate--2-oxoglutarate transaminase VF0922 Achromobactin biosynthesis and transport VFC0272 Nutritional/Metabolic factor MSVTSVNPATNATNEYYLTRQSQMESNVRSYPRKLPLAIAKAQGCWVTDVEGTQYLDCLAGAGTLALGHNHPAVIQSIQDTLASGLPLHTLDLTTPLKDAFTEALLAYLPGGKEEYCLQFCGPSGADATEAAIKLAKTYTGRSSVISFSGGYHGMTHGSLAMTGNLSAKNAVNGLMPGVQFMPYPHEYRCPLGLGGEAGVDALTYYFENFIEDVESGVTKPAAVILEAIQGEGGVVTAPVKWLQKIREVTEKHNIVLILDEVQAGFARSGKMFAFEHAGIEPDVVVMSKAVGGGLPLAVLGIKRKFDAWQPAGHTGTFRGNQLAMGTGLVVLETIKEQNLAQNAQERGEFLQAELKKLATEFPCIGNVRGRGLMIGVEIVDERKPADRIGSHPADSQLAAAIQTACFNNKLLLEKGGRNGTVIRLLCPLIITQEECVEVIARFKKAVAEALVAVRGA Kraken2_NZ_CP077849.1 IMICODJL_39125 Prodigal:2.6 125665 126963 - VFG013203(gb|WP_012341659) 63.6 1.47e-195 (hemL) glutamate-1-semialdehyde 2,1-aminomutase VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MSLSPKQEQLFKQASKHIPGGVNSPVRAFNGVGGTPVFIEKAKGAYLWDVDGKRYVDYVGSWGPMILGHAHPDIIKAVQTAAEDGLSFGAPTVHETTLADIICEIMPSIELVRMTNSGTEATMTAIRLARGYTGRDKIVKFEGCYHGHSDSLLVKAGSGLLTKGEGEPTSKGVPADFAKHTLTLPYNDVAALKECFAKFGHEIAGVIIEPVAGNMNMVKPIDGFLQAIRDVCDEYKSVFIIDEVMTGFRVALGGAQSVYNVKPDLTTLGKIIGAGLPVGAFGGKREIMECIAPLGGVYQAGTLSGNPLAMRAGIEMFKHLRQPDFYSKLSAQLEKLLAGLQAAADEAGIPFKTQQAGAMFGLYFTDQEDITSFDSMLACDIEAFKKFFHGMLKRGVNLAPSAFEAGFISSAHSDEDIEFTIQAAKETFAEMK Kraken2_NZ_CP077849.1 IMICODJL_39238 Prodigal:2.6 240427 241386 + VFG037757(gb|YP_005799955) 100.0 1.3199999999999998e-234 (lpxM) putative lipid A biosynthesis lauroyl acyltransferase VF0466 LPS VFC0258 Immune modulation LpxM dependent acylation of lipid A is essential for A. baumannii desiccation survival, a key resistance mechanism for survival in hospital environments Evasion of the host immune response, triggering the host inflammatory response MNYQLLKTFSRQPIQFGRFLARLLAGLVNTLKITRTSKSIELNLRIALPYLTPQQRIAITEKAVRNELTSYFEFLSIWGSSNSKNISRIHRIEGEHFFHEALAAKKGVVLIVPHFGTWEVMNAWCAQFTSMTILYKPVKNADADRFVREARSREQANLVPTDESGVRQIFKALKQGETTVILPDHTPNVGGDMVNYFGVPLASSNLSAKLIQKTKAKALFLYAIRNENDGFTMHIEPMDEKIYEGTADDGTYVIHQAIEQLIYQYPEHYHWSYKRFKANPALDNIYNIDPTEALKIVDRLKAEALKTSTQPEPIQTSVM Kraken2_NZ_CP077849.1 IMICODJL_39294 Prodigal:2.6 305675 307309 - VFG045692(gb|WP_197532029) 72.2 1.02e-270 (htpB) Hsp60, 60K heat shock protein HtpB VF0159 Hsp60 VFC0001 Adherence Mediate a complement-independent attachment to mammalian and amoebal host cells Specific receptors have not been identified MSAKDVKFGDSARSKMIAGVNVLADAVKVTLGPKGRNVVIDRSFGAPHITKDGVTVAKEISLKDKFENMGAQLVREVSSKTNDIAGDGTTTATVLAQAILNEGIKSVTAGMNPMDLKRGIDIAVKTVVENIRSIAKPADDFKAIEQVGSISANSDTTVGKLIAQAMEKVGKEGVITVEEGSGFEDALDVVEGMQFDRGYISPYFANKQDTLTAELENPFILLVDKKISNIRELISVLEAVAKTGKPLLIIAEDVEGEALATLVVNNMRGIIKVCAVKAPGFGDRRKAMLQDIAILTGATVISEEVGMSLEQATLQDLGTAHKITVSKENTVIVDGAGDAAAIAERVQQIRAQIEESTSEYDREKLQERVAKLAGGVAVIKIGAATEVEMKEKKDRVDDALHATRAAVEEGVVAGGGVALVRAVNALEGLKGANEDQTAGINILRRAIEAPLRQIVANAGDEPSVVINAVKNGEGNFGYNAATGEYGDMLEMGILDPAKVTRSALEHAASVAGLMLTTECMITDIPEDKPAAPDMGGMGGMGGMM Kraken2_NZ_CP077849.1 IMICODJL_39327 Prodigal:2.6 349126 364797 - VFG037636(gb|WP_001187640) 79.5 0.0 (bap) biofilm-associated protein VF0462 Bap Biofilm-associated protein VFC0271 Biofilm A large cell surface protein comprised of multiple copies of repeat elements; Bap homologues have also been identified and characterized in other bacteria, including members of other genera typically associated with hospital-acquired infection, such as Staphylococcus, Enterococcus, and Pseudomonas Bap proteins exhibit poor sequence similarity, but share structural similarities, as they are internally repetitious and feature multiple (3 to 50 copies) immunoglobulin-like domains. These domains have a peculiar three-dimensional structure known as Ig fold, composed of 70~100 amino acid (aa) residues in seven anti-parallel beta-strands organized in two beta-sheets packed against each other in a sandwich structure Contributes to biofilm formation and adhesion to eukaryotic host cells MAAGQYAPVLDPINATDPVSGQAEPGSTVTVTYPDGTTATVVAGTDGSWSVPNPGNLVDGDTVTATATDPAGNTSLPGTGTVSADITAPVVALDDVLTNDSTPALTGTVNDPTATVVVNVDGVDYPAVNNGDGTWTLADNTLPTLADGPHTITVTATDAAGNVGNDTAVVTIDTVAPNAPVLDPINATDPVSGQAEPGSTVTVTYPDGTTATVVAGTDGSWSVPNPGNLVDGDTVTATATDPAGNTSLPGTGTVSADITAPVVALDDVLTNDSTPALTGTVNDPTATVVVNVDGVDYPAVNNGDGTWTLADNTLPTLADGPHTITVTATDAAGNVGNDTAVVTIDTVAPNAPVLDPINATDPVSGQAEPGSTVTVTYPDGTTATVVAGTDGSWSVPNPGNLVDGDTVTATATDPAGNTSLPGTGTVSADITAPVVALDDVLTNDSTPALTGTVNDPTATVVVNVDGVDYPAVNNGDGTWTLADNTLPTLADGPHTITVTATDAAGNVGNDTAVVTIDTVAPNAPVLDPINATDPVSGQAEPGSTVTVTYPDGTTATVVAGPDGSWSVPNPGNLVDGDTVTATATDPAGNTSLPGTGTVSADITAPVVALDDVLTNDSTPALTGTVNDPTATVVVNVDGVDYPAVNNGDGTWTLADNTLPALTDGPHTITVTATDAAGNVGNDTAVVTIDTVAPNAPVLDPINATDPVSGQAEPGSTVTVTYPDGTTATVVAGTDGSWSVPNPGNLVDGDTVTATATDPAGNTSLPGTGTVSADITAPVVALDDVLTNDSTPALTGTVNDPTATVVVNVDGVDYPAVNNGDGTWTLADNTLPALTDGPHTITVTATDAAGNVGNDTAVVTIDTVAPNAPVLDPINATDPVSGQAEPGSTVTVTYPDGTTATVVAGTDGSWSVPNPGNLVDGDTVTATATDPAGNTSLPGTGTVSADITAPVVALDDVLTNDSTPALTGTVNDPTATVVVNVDGVDYPAVNNGDGTWTLADNTLPALTDGPHTITVTATDAAGNVGNDTAVVTIDTVAPNAPVLDPINATDPVSGQAEPGSTVTVTYPDGTTATVVAGTDGSWSVPNPGNLVDGDTVTATATDPAGNTSLPGTGTVSADITAPVVALDDVLTNDSTPALTGTVNDPTATVVVNVDGVDYPAVNNGDGTWTLADNTLPTLADGPHTITVTATDAAGNVGNDTAVVTIDTVAPNAPVLDPINATDPVSGQAEPGSTVTVTYPDGTTATVVAGTDGSWSVPNPGNLVDGDTVTATATDPAGNTSLPGTGTVSADITAPVVALDDVLTNDSTPALTGTVNDPTATVVVNVDGVDYPAVNNGDGTWTLADNTLPTLADGPHTITVTATDAAGNVGNDTAVVTIDTVAPNAPVLDPINATDPVSGQAEPGSTVTVTYPDGTTATVVAGTDGSWSVPNPGNLVDGDTVTATATDPAGNTSLPGTGTVSADITAPVVALDDVLTNDSTPALTGTVNDPTATVVVNVDGVDYPAVNNGDGTWTLADNTLPTLADGPHTITVTATDAAGNVGNDTAVVTIDTVAPNAPVLDPINATDPVSGQAEPGSTVTVTYPDGTTATVVAGTDGSWSVPNPGNLVDGDTVTATATDPAGNTSLPGTGTVSADITAPVVALDDVLTNDSTPALTGTVNDPTATVVVNVDGVDYPAVNNGDGTWTLADNTLPALTDGPHTITVTATDAAGNVGNDTAVVTIDTVAPNAPVLDPINATDPVSGQAEPGSTVTVTYPDGTTATVVAGPDGSWSVPNPGNLVDGDTVTATATDPAGNTSLPGTGTVSADITAPVVALDDVLTNDSTPALTGTVNDPTATVVVNVDGVDYPAVNNGDGTWTLADNTLPTLADGPHTITVTATDAAGNVGNDTAVVTIDTSLPVVSLDDLTTNDTTPALTGAIDDPTATVVVNVDGIDYPATNNGDGTWTLADNTLPALIDGPHTVAVTATDPAGNTATDTATLTIDTVPADLIGAITIPEDLNGDGILNADELGTDGSFNAQVALGPDALDGTVVNVNGVNYTVTAADLANGYITAAIPVTGEGPVAIHAEAVDAQGNVDVADADVTVTVDTVPADLIGAITIPEDLNGDGILNADELGTDGSFNAQVALGPDALDGTVVNVNGVNYTVTAADLANGYITAAIPVTGEGPVAIHAEAVDAQGNVDVADADVTVTVDTVPADLIGAITIPEDLNGDGILNADELGTDGSFNAQVALGPDALDGTVVNVNGVNYTVTAADLANGYITAAIPVTGEGPVAIHAEAVDAQGNVDVADADVTVTVDTVPADLIGAITIPEDLNGDGILNADELGTDGSFNAQVALGPDALDGTVVNVNGTNYTVTAADLANGYITAAIPVTGEGPVAIHAEAVDAQGNVDVADADVTVTVDTVPADLIGAITIPEDLNGDGILNADELGTDGSFNAQVALGPDALDGTVVNVNGVNYTVTAADLANGYITAAIPVTGEGPVAIHAEAVDAQGNVDVADADVTVTVDTVPADLIGAITIPEDLNGDGILNADELGTDGSFNAQVALGPDAVDGTVVNVNGTNYTVTAADLANGYITAAIPVTGEGPVAIHAEAVDAQGNVDVADADVTVTVDTVPADLIGAITIPEDLNGDGILNADELGTDGSFNAQVALGPDALDGTVVNVNGVNYTVTAADLANGYITAAIPVTGEGPVAIHAEAVDAQGNVDVADADVTVTVDTVPADLIGAITIPEDLNGDGILNADELGTDGSFNAQVALGPDAVDGTVVNVNGTNYTVTAADLANGYITAAIPVTGEGPVAIHAEAVDAQGNVDVADADVTVTVDTVPADLIGAITIPEDLNGDGILNADELGTDGSFNAQVALGPDAVDGTVVNVNGTNYTVTAADLANGYITAAIPVTGEGPVAIHAEAVDAQGNVDVADADVTLTIDTTPQDLITAITVPEDLNGDGILNAAELGTDGSFNAQVALGPDAVDGTVVNVNGTNYTVTAADLANGYITATLDATAADPVTGQIVIHAEAVDAQGNVDVADADVTVTIDTTPQDLITAITVPEDLNGDGILNAAELGTDGSFNAQVALGPDAVDGTVVNVNGTNYTVTAADLANGYITATLDATAADPVTGQIVIHAEAVDAQGNVDVADADVTLTIDTTPQDLITAITVPEDLNGDGILNAAELGTDGTFNAQVALGPDAVDGTVVNVNGTNYTVTAADITNGYITAILAATAADPVTGQIVIHAEAVDAQGNVDVADADVTLTIDTTPQDLITAITVPEDLNGDGILNAAELGTDGTFNAQVALGPDAIDGTVVNVNGTNYTVTAADITNGYITAILAATAADPVTGQIVIHAEAVDAQGNVDVADADVTVTLDVTPPDITTTVLAIDPVTADNILDATEAGGTVTLTGTLTNVPADATTTGVVVTINGNDYTATVDAIAGTWTVNVAGNDLALDPDLTVDAKATFTDLAGNSSTLQDTQTYTLAGSITAFDNTDHAVLSPKPALVGDDVSLGSTSYLVLTSVAGLDLQLGGNSLGFTVDAGHEGDVTFQYSGLIDAAVLSDYKLVVQKFNTTTNQWESIHGDANSSLISLHLLGIGTGNVPGAVLDGLDAGQYRAFLAYDGLLGLGVLGTLSATMDDYDLSVAGGYEIGNAEGNVITDPDPTTGQVDQVTANTYVSSVNGHPIDADGETFAGTYGTITFYQDGSYVYVPNADGSGVGQTDVFTYTLTDSVTGATGQANLNIVFDSIRAADNLVEVELNPQYQLVGTETDSAFYGVLLNVGNIVDLQLLTVDTVDFTIGAGQEGVATFNFNSLIGASALGDYNVVLQKYNDVTGQWEAVNGTGDRSLLNLTLLGNTPTAQIGGLTEGEYRAFLSFNGLVGGAVAVTLNGSVDVYNPAVITGYDVVAAHGNLISDPNTNGDVDIATPNSIISEVNGVAVSASPTEIIGTHGTLLIYANGDYTYTPNADSAGLGQVDQFTYTLLDPASNITSQATFYVHLDSKVVDMNWDAADPSQPATVTITAVDDAVNAAIAAEPHLIEDDRALGSATYLALLSLAGINLQAPLPFVNSTVEFNVGAGETGTATFKYSSLINEGALGDYQLVVQKFNTATNRWESITGSSEASLLNLSVLGIGVNATPGVVVEGLDEGQYRAFMTYNGLYGKSILGTLSGTMDVYDPNQIDFTGLASEGNVITGLGVGTNADAVTGYTIVDSVTVNGVTTNVDPNTGTIIQGQYGTLQIFANGDYIYTPNNTNANLGLVDHFTYTLADPLGGNISASLDFTIGNSTPVIAVDDLAVAVVNPEYLQIGNDVAVDSYLYVALLSLTDNFDFQLGGQGVDFTLTDSTLNDVTFNYSALIDASLLADYVLVVQKFDTATNQWVAVNGTGEADLLSLAAFGGNSVTLEGLAAGQYRAYMTYAGSGVGVSLLGTLSVQKDVFDATNITGYSTQVAEGNVIHDVGLNGHADTASGFSTVTSVEFNGTAFAVNATGVTTIVGDHGTLSIYANGNYSYQPNGEAASLGQVDQFTYTLSDGLNTSQATLYLHIDSDAVDMTWNTSDPSQPAVITVTPVDAIDNVVSAGVDIVPQGELGVAVGSATYLALVGITEDLNVSLLGTPSVAFTIDAGHEADVTFAYAPVLSLSLFNDYKVVLQQKGADGAWHNIDGGSSTGLLNIGLLGNGGIGVTVPDLGQGEYRAFMVYTGLGVGILGTMSVVKDDFDYTVAPTNTAVVADGNVLTDDVTTLTTQVTTVTSEVVGALPQTVGTDTVINGAYGTLVISTNGHYTYTPNTTDLSAIGKVDSFTYTIRDVLTGATDTATLHVQVGSPDVTIAWDAANPANDGVVQLTANPDHVVTTTDFSNAADLPVDVASPVVSVNLIGSNSVVSDQFVVGAGTVANIDLSAVYTAQPLASVLPTVSYVIQSWNGTAWVNTIYSGSQTALGSVATIQAGSVAFQDTVEHLAAGTYRVQYTLTGVSLGATSLDTNVSTTTVHLDTYRSDWISGNVLAGDNIGGVADTGILSHEGAKLQVWDNAQNAYVDAVGQTINTGNGVLIMQSNGEYEYRPNDVTTTTQLASTDSINYKIVSVTGGVESQSTLTIDLTHTDYNLLYTSTSANDTFTTGTGSDTVIYQLLNGTAATANNGANTGGNGVDTWTDFHVGNVATDKQADLIDIRALLDGDQTDANIGQYLNVTTSGGNTTIQIDRDGLSGLIPGNNFTTLLVLQGVTTTETELLNNGQILY Kraken2_NZ_CP077849.1 IMICODJL_39449 Prodigal:2.6 492897 494975 - VFG050670(gb|WP_000505931.1) 100.0 0.0 (pilJ) methyl-accepting chemotaxis protein VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MGFKLKKKSGNRGATGKSSVNFIAKIQSKIEQFASLFGESEKSKPILYAALLCLVCALISLAYLFYNVPRHNQLIRSLGELRLLSQTISKQATEATESGSQEAITKLQQSKKDFDENLLEIENIHGKSTDEYQKVEKIWGEVSKNIDLISSHQRVLNQLYDTNISISETVPEIQAEYNLMVDQMARQGLPSSQVIIAKNQVFIAERILRSINSVLSGTDGNVSTSDFSVDIETFGTYLNAELNGNAELGVDRIADPALRESLESIKSEYDKVLKSAAATVLKNGSQIVNVRQASSQIFSKSDVMLESLGHLSDVARKNWLTLFLGAVLILSLGGLIFSVFKLITLRSVMDKQRVARLQEEYDRNQNAILRLLDEIADLADGDLRSYATVSEDFTGAIADSINFAIDQLRDLVSRIHETSQEVARYTQDTQSITNQLAEASEHQAQEIAGASTAMNEMAQSIDQVSANASESAEVAQRSVQIASNGAQVVNRSIEGMDTIREQIQETSKRIKRLGESSQEIGNIVSLINDIADQTNILALNAAIQASMAGEAGRGFAVVADEVQRLAERSASATKQIETLVKTIQTDTNEAVISMEQTTTEVVRGANLAKDAGIALDEIQKVSGDLAKLIASISDAAKLQSASASHIATTMTVVQEITSQTTTATFDTARSVSELANMAESLRESVTDFKLPD Kraken2_NZ_CP077849.1 IMICODJL_39450 Prodigal:2.6 495022 495558 - VFG050655(gb|WP_000729757.1) 100.0 1.09e-131 (pilI) chemotaxis protein CheW VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MAANGFIELLRLSKRGNKNYASVQNEAQRWSGIAFEMRGQYFVAPLGEVSEVIYPPKYTPVPNTQSWVKGLANIRGRLLSVSDLAHFISGQRSSFSSTQKVLCISHHDQYVGLVVDQVLGIQHFNKKSFFSESLDLEENLKEYCQGYFHQHNQHWHVFLFSRLLQNPHYMNASTKFIN Kraken2_NZ_CP077849.1 IMICODJL_39451 Prodigal:2.6 495619 495981 - VFG050640(gb|WP_000101096.1) 100.0 7.29e-84 (pilH) response regulator VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MARILIVDDSPTETFRFKEILTKHGYDVLEASNGADGVTLAKAEQPDLVLMDVVMPGVNGFQATRQITRDEDTKHIPVVIVSTKDQATDRVWGKRQGAIDYLIKPIEEKQLIDVIKQFLN Kraken2_NZ_CP077849.1 IMICODJL_39452 Prodigal:2.6 496005 496388 - VFG050625(gb|WP_000389061.1) 100.0 1.14e-88 (pilG) twitching motility response regulator PilG VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MEDAFQNLKVMVIDDSKTIRRTAETLLQREGCEVITAVDGFEALSKIAEANPDIVFVDIMMPRLDGYQTCALIKNSQNYQNIPVIMLSSKDGLFDQAKGRVVGSDEYLTKPFSKDELLNAIRNHVSS Kraken2_NZ_CP077849.1 IMICODJL_39482 Prodigal:2.6 524429 525499 - VFG038176(gb|WP_000777882) 100.0 3.23e-256 (ompA) outer membrane protein OmpA VF0464 OmpA Outer membrane protein A VFC0258 Immune modulation PDB code: 4G88 3TD3 OmpA localized to the mitochondria and induced apoptosis through the release of the proapoptotic molecules cytochrome c and apoptosis-inducing factor; facilitates the persistence and survival of A. baumannii by assisting biofilm formation and surface motility; interacts with soluble inhibitors of the alternative complement pathway and allows the bacteria to avoid complement-mediated killing; plays a role in adherence and invasion of epithelial cells may contribute to the dissemination of A. baumannii during infection MKLSRIALATMLVAAPLAAANAGVTVTPLLLGYTFQDSQHNNGGKDGNLTNSPELQDDLFVGAALGIELTPWLGFEAEYNQVKGDVDGASAGAEYKQKQINGNFYVTSDLITKNYDSKIKPYVLLGAGHYKYDFDGVNRGTRGTSEEGTLGNAGVGAFWRLNDALSLRTEARATYNADEEFWNYTALAGLNVVLGGHLKPAAPVVEVAPVEPTPVAPQPQELTEDLNMELRVFFDTNKSNIKDQYKPEIAKVAEKLSEYPNATARIEGHTDNTGPRKLNERLSLARANSVKSALVNEYNVDASRLSTQGFAWDQPIADNKTKEGRAMNRRVFATITGSRTVVVQPGQEAAAPAAAQ Kraken2_NZ_CP077849.1 IMICODJL_39483 Prodigal:2.6 525881 526396 + VFG050610(gb|WP_000477147.1) 100.0 2.5e-120 (fimT) GspH/FimT family pseudopilin VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MFKSPGFTIVELTITLVILVIMSVIAIPLYHQFMASVELKNTPRILTIHIQKAKYDAIIRHKNVVLCPSSDQLVCNTNWDNRVISFVDNNHNLQHDLNEELLTSIDLNHHYGSMKLQRFGKKQNSIIFQGSSGLPIESNGSFIYCSYDQLKNFKLILSKMGHVRLEELKNC Kraken2_NZ_CP077849.1 IMICODJL_39588 Prodigal:2.6 636325 637950 + VFG037203(gb|WP_000079188) 100.0 0.0 (plcD) phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase VF0469 Phospholipase D VFC0235 Exotoxin Contribute to the pathogenesis by aiding in the lysis of host cells, via cleavage of phospholipids present in the host cell membrane, and by degrading phospholipids present at mucosal barriers to facilitate bacterial invasion Lipolytic enzyme that catalyzes the cleavage of phospholipids MAQSFHSKQLQTHQLANGFLIKASIVVCSSFAVALTGCSTLPKHSPEPIQYARDIDTSQTSLSKIITPLREKNPNLTGYHLLNDPLEALAARLRLIDKAEKTLDLQYYIWDNDKVGALALHAIIRAADRGVKVRLLIDDNNAKKMEGVLLALSQHKNIEVKLFNPYRFRKYRAMDMILDLKRINRRMHNKSFIADNQVALIGGRNMTNQYYNVSDSYQFSDVDVMLVGAAVDDIVNSFDDYWNHEYAYSVQSIVSAQQHRLRYESLKQQLDAHYQQATVQNFLDLTSRSHAFDKWLDRNIKFDWVKAEVVKDSPDKIRSKAKKEEHLNFQLINHLEKPESNVDLISAYFIPEKQGAKILSTLAKEGVEVRVLTNSFKANDVAVVHAFYGKYRKELLKNGVQLYEFLPTPDKRDLNKNTDELATKAKVNMKGLSRSSLHTKLMALDEQVFIGSFNFDPRSAYLNTEIGVILDSPSLAKTIHHTMDENLNKYAYKLKLDPNNHIYWQQETPKGPVIYKKEPEMKWWQKAGMKLLSWLPLEGFM Kraken2_NZ_CP077849.1 IMICODJL_39768 Prodigal:2.6 804517 804942 - VFG050595(gb|WP_000788342.1) 100.0 7.64e-96 (pilE) type IV pilin protein VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MKNGFTLIEIMIVVAIIAILAAIATPSYLQYLRKGHRTAVQSEMMNIAQTLESEKVVHNRYPSNATIQSIYGSNVSPIQGQALYKLAFATLNDSTWVLTATPISTSSQAGDGIICLNDQGQKFWAKGATVCALSASSSWTE Kraken2_NZ_CP077849.1 IMICODJL_39769 Prodigal:2.6 804939 805421 - VFG050581(gb|WP_001046420.1) 100.0 1.1199999999999998e-104 (ACICU_RS16840) prepilin-type N-terminal cleavage/methylation domain-containing protein VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MNKYSILRFNQGVTLIELMVVIVIVAIFASIAIPSYQSYSRRATASAAKSEILKLAEQLEQHKSRNFTYRGFTTTSITLPRGGYTIQITDDTTTGNLLTNSASNGQTWVIKATTTDSRNFNFIAKNSGLRCQSLTATAVDNDCGGTVTCNVCETNSENWQ Kraken2_NZ_CP077849.1 IMICODJL_39770 Prodigal:2.6 805434 809300 - VFG050570(gb|WP_000768970.1) 100.0 0.0 (pilY1) VWA domain-containing protein VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MGNIMKLKLKNFKPNNLWYAVYSSSMIFTWLMTSSVVQASDLQIYASPTAGKKTIVMMLDTSGSMTNNSYGENRLAMLKNGMNAFLASNNPVLNDTRVGLGNFSANGDSRSGQILVAAAPLGDASTLNTVGSQRYKLKQAVANLTAGGSTPSAHAYAEAAAYLMGTTTYSETNYAIRKDSYIKRVRRSDNRTEYSYCTNYRDSQIDTANLWQPCRSNSYWSSWSTNNPGVDNATAYDTSSDWTYYYTYYYTTFNYAVANADSGIPKSKSNDTASNPNIVVDRNATNSNAVYQSPLPAVANRQSCDGQGIYFLSDGEPNNTTNTRSASVMSTALGSTFGADFNCSGGLSNTTADSGWACMGEFAKRLFDKTKNPAGVSIQTAFVGFGSDFSSLSSSDVKNACRLSSRTQSDRKGDDACSPNQSTNAVAAPGYGNGGFFPTQSSQGVTDSVIAFINNLDKVPLEPLTTGAISVPYDALNPKNLQEYGYLRAFEPNPANTYLTWRGNLKKYHVVLSGANAGTFEANTGGLVYNATGAFRTGTKDYWNSSTYNDGGKVFFGGSYAKVPLPIAGQPETRDEEGNITKYYYAVQTKIRNLFTDVSAVASDGSLTKISTSGTNLLKIPAAPPEGTNPFDTVANTASYVLGKFDPSTGQNILKAFPISLKLKILNYLGYSTDINATTLPSSLVTSNEPYLSMGGSIHSLPVQLTYNGTLDDNGNLTSAREQSILYGTMEGGLHIVDASSGIEQMVFVPADILNDSVASKALVVGQSDASAPAHGMDGAWVSDPAYNITTVGSGSSAVSKVTAKQMNIYGGMRMGGSSYYGLDVLSPTSPKLLFRIGADQTDYSRMGQSWSKPVLANIRYNGSIRRVLIVGGGYDQCYEKPNITLTDACFTNGKAKGNAVYIIDAKTGQRLWWTSDTGSNTDNANMKHSIVSRISTLDRDADGLVDHLYFGDLGGQIFRVDLNNNQTKTNSTYSSFGVRVVRLANLATNDSTYDGTNDYTGGNAPRFYEPPTVTIHDYGIHTFITLGIASGDRSTPLDVYPLTGREGMTPASALSGRPVNNVYGIIDRDFVKKNLMSLTDNQLETKDITRTGLRKNPQILRTGETRVAQIFFPTTGVGKGGWYRSLSSTSDGTEKANNSFRIKGGLKAFEEPMAITGNLIIPVYDPQGTGIVAADPCLPRVVGETDRQTYCLPFGACLNPDGTINSNKENPSGFQTKTGSNCPAGVSECNTNVIGAGIRNITFVPKRDEPPVTNSCGKLQLSGNENGTGEWQCTSHLLPVRWYERYR Kraken2_NZ_CP077849.1 IMICODJL_39771 Prodigal:2.6 809300 810118 - VFG050551(gb|WP_000149374.1) 100.0 6.42e-182 (pilX) hypothetical protein VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MTHLNYKNIKGRSKETGATLIVVLIILLIVISVGVLAIRVAIVSLKVATNSQVGQLNFQSSDTPLELIVQMNPTTLTNITNVIGAALKAHESNPGAEYNFCYKPTSTSVSFAQTRGASLLRAGSANNAVVEDGGVAGFCDLTSDYGSNRQAVVTQVAVSIPTDAMADIPGSNLPRDINLSEGTQLPKSMLSTQRIRVITTAFLPAYASTSLETLQSDCLSTSSAKISDNFDSALTDKQTLADCLANHNVPFSTQVQEFNYTNKLTEITAPGS Kraken2_NZ_CP077849.1 IMICODJL_39772 Prodigal:2.6 810115 811116 - VFG050537(gb|WP_000079200.1) 100.0 7.939999999999999e-234 (pilW) PilW family protein VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MAQSFISNKEQGFTLIELIVALALGLILVAAATQLFIGGLLSSRLQKANAEIQDSGIFGLEYMARDIRLLNYGNVVNPQLTDTTPWGGIVLTGSTATNANNINFIPKVDTNTYIPEALLSRGAGDTVSTVNNYWKGLSNIQNSSNAEVQSDQLTIQFIAPTNMTNCEGVNVLAGDLIVQRYFLRVDNNGSSQQDYALACDANTPAVSATAQPDIVNGLGDAGQIILPRIDHFHVLLGAKNAAGNFAYYTIPQYRVAAQAARDASPAVAAPRILSIQISVLARSTNNAQNKAIDPNQSFLMLDQNVHAADNRTRFLRRVYSVTIALRNAMGETI Kraken2_NZ_CP077849.1 IMICODJL_39773 Prodigal:2.6 811117 811671 - VFG050535(gb|YP_005800456.1) 100.0 4.38e-125 (pilV) type IV pilus modification protein PilV VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MHHYKQKAQAGVGLLEVLVALILLAIGVLGYVALQLRAMDASSEALSKSQAILVMRGLAENIRTNSTQASQYPTFVRSYSNYTSDTPAPTSCFNSLCTASQLAQFDAYQAARNANQLGMRITMSNCPGVTNTMVQQRQCLFVFWGRTAPVITTNGTNTSVDVSSCMSNNGVYVNNSTCLMMEAY Kraken2_NZ_CP077849.1 IMICODJL_39774 Prodigal:2.6 811671 812144 - VFG050511(gb|WP_001214061.1) 100.0 7.88e-99 (fimU) GspH/FimT family pseudopilin VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MRGIIPQEGFTLVELMVTIAVMAIIALMAAPSMSNLLESKRLDANQRDLINTLSEAKSQAILGRQNVSVNLNSTASNTPTSLNWQTASNNTLELKNIAADGTQSSLTTTTLAFNANGVVANITQDTLLSICNSRINKKKVIILSKLGTLVFKAEENC Kraken2_NZ_CP077849.1 IMICODJL_39784 Prodigal:2.6 821443 821877 - VFG050440(gb|WP_000993717.1) 100.0 2.7399999999999997e-95 (pilA) pilin VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MNAQKGFTLIELMIVVAIIGILAAIAIPAYQNYIAKSQVSTGLADITAGKTNAETKLAEGLTAALTDVTTLGLQQSTNACAITANIGTNGASNITCTLKGTSQINGKKIEWIRDADNATNGTTGAWRCKTDVAENLRPKSCGAS Kraken2_NZ_CP077849.1 IMICODJL_39794 Prodigal:2.6 834671 836836 - VFG050372(gb|WP_001017033.1) 100.0 0.0 (pilQ) type IV pilus secretin PilQ VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MNHVFRQFSMGAVAIAIMQAASAQVSMTNIVPMQIAGQGTEIRVMFNGLPPQPQAYQLENPSRLILDFDKAQQGLKQSKISVATNEASSVDVTSDDQRSRLTVNLKDAGAFTTRVEGNTFILKINSAQTSNKPLPVVSAQPQGVSNIGFQRGSQGEGLVVVDLLGSNTPVDVQQQGSKVVIRTIGTKIPTHLARRLNVNDFATPVSSIDAYNDKGVGVITIQSSGSYEYMAYQAENKLTISLKRPQDKNVTSLYKTPNYSGNKLSLDFQDIEVRRVLQLLADFTGINMVAADSVQGNITLRLKDVPWDQALDIILKTKNLDKRRNGNVIWIAPVAELIKAEEEEAKAVAQSVKLAPLQTEYIQLKYAKAGDIMGLITQGSNNSNGLQHTSGGGTSTSTNLNTGVDSLGNNVGSLLSPRGTITQDDRTNTLIINDTAQSIDQIRKMIDLLDVQVKQVMVEARIVRASTSFTKELGVKWGILSQGITNNNNLLVGGSETTLWNLREPKKDETTGGYKYTIERPDNLNVDLGVSNPAGSIAFGLISMSDFMLDLELSALQADGYGEVISTPKVMTADKQTAKVATGQQVPYQSTTNSAAGSTATTSFKDALLSLNVTPSITPDGKIQMKLDISKDSVAGAAPNGELILNKNNINTNVLVDNGETVILGGVFEQTTMNSQTKVPFFGDIPVVGRLFRKDVKSDDKQELLIFVTPRIVNDTLARNH Kraken2_NZ_CP077849.1 IMICODJL_39795 Prodigal:2.6 836904 837431 - VFG050357(gb|WP_000695065.1) 100.0 2.1200000000000002e-123 (pilP) pilus assembly protein PilP VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MKIKQITLYVLACAVLVGCDSRIDAVNQEMANIRNQPPLPIEPAPIFTPVPQFNYAAHQLKSPFMPSSLAAELKIMAGKRVYPNFSRAPQPLESYALEALNMKGSMRNNRGQILALIQTPDQQIERVQVGNYMGMNQGRITHISPTQIDLVEIVPDGREGYVERPRTLVLIGPAP Kraken2_NZ_CP077849.1 IMICODJL_39796 Prodigal:2.6 837442 838182 - VFG050353(gb|WP_000076101.1) 100.0 6.46e-169 (pilO) type 4a pilus biogenesis protein PilO VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MSQDELQELSLEQLSAKKKKFNLDKFLQQFNTLDMNNYGSWPISVKITCWIFIFFAVLALGYFIVIQPKLQAIDNAQAQESNLLNEFREKDSKLRNLQQYQVQLQEMQANFNQQLEQLPKETEIPSLVEDINLTGVNSGLKFKNIRLEDEVKQEIFIEQPIAIEATGDYHAFGAFVSSIAALPRIVTMHDFTVDVSPAKDNKSDIPVLNYSIKAKTYRYVGATDTSEQTGKAPAASASTNTTVQPK Kraken2_NZ_CP077849.1 IMICODJL_39797 Prodigal:2.6 838179 838820 - VFG050328(gb|WP_000201227.1) 100.0 1.31e-138 (pilN) PilN domain-containing protein VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MATINLLPWREELREQRKKQFITLCFGVVVLGITTVFGGWFYFDHKLDDQEQANQLIMSTNQNLDQQLKTLNGLQEQRDAIIERMKLIQGLQSQRPVVVRLVDELVRVTPSAMYLTKFSRTGDKFTIEGKAESPNTVAELLRNLEASPWYRNAFMNSFLANEEKKDKAASSLLPRVEDHYGSFVVTVDLGEMGVTTTDDSAKPSTGESVGAAK Kraken2_NZ_CP077849.1 IMICODJL_39798 Prodigal:2.6 838820 839878 - VFG050321(gb|WP_002014066.1) 100.0 2.33e-247 (pilM) pilus assembly protein PilM VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MLRLYRKPNKGLMGVDISSTSVKLLELSVKNGKYWVESYALMPLPENSVVEKNILNPEAVAEALERAMNLANPQTTHAAIAVPTSTVIHKTIEMDADMSDDEREVQIRVDAEQYIPFPLDEVSLDFEVLPDRLANPNRVNVLLVATRTENVETRVEVLELADLNPKLADVESYAVERAFSVFADSLPMGANTIGILDIGHTMTTLSVMQNGKIIYTREQVFGGKQLTLEIQSRYGLSLEEASRAKKDRSLPDDYEIEVLDPFLDAVVQQAARSLQFFFSSSQFNEIDHILLAGGNANIPGLAKLLQQKLGYRVTIANPFLQMGFSPQVDVQKIENDASSLMVACGLALRSFD Kraken2_NZ_CP077849.1 IMICODJL_39941 Prodigal:2.6 987855 988757 - VFG037822(gb|WP_000240700) 100.0 1.03e-217 (lpxC) UDP-3-O-acyl-N-acetylglucosamine deacetylase VF0466 LPS VFC0258 Immune modulation LpxM dependent acylation of lipid A is essential for A. baumannii desiccation survival, a key resistance mechanism for survival in hospital environments Evasion of the host immune response, triggering the host inflammatory response MVKQRTLNRVVKASGIGLHSGQKVMINFIPHTVDGGIVFRRIDLDPPVDIPANALLIQEAFMCSNLVTGDIKVGTIEHVMSAIAGLGIDNLIVEVSASEVPIMDGSAGPFIYLLMQGGLREQDAPKKFIKILKPVEALIDDKKAIFSPHNGFQLNFTIDFDHPAFAKEYQSATIDFSTETFVYEVSEARTFGFMKDLDYLKANNLALGASLDNAIGVDDTGVVNEEGLRFADEFVRHKILDAVGDLYLLGHQIIAKFDGYKSGHALNNQLLRNVQSDPSNYEIVTFDDEKDCPIPYVSVT Kraken2_NZ_CP077849.1 IMICODJL_39975 Prodigal:2.6 1024299 1027625 - VFG050929(gb|WP_000898324.1) 100.0 0.0 (vgrG/tssI) type VI secretion system tip protein VgrG VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MLFNIFSVLEKIGLNAQKRAIHVQFSNELLNHQVFLQRIEGQHQLNGGLMAELICLSTNAQIALKQFIGVQVAVDQVTDSGQLFRTTGIVTEASYGQSDGALTLYKLTIEDATNLWHKRRNSRVFMNKSIVEITEVLFKEWQEKSPLFAASLSLDLGGLSQNYDIRPFTMQHNEADYDFLTRLWRSEGVSWLIDESELFVPHFTAPIQAQKLRLIDDNNQYQALARRSIRYHRSSATEYQDSITGFVAVRSLQPTAVHVQRWQPDALAQEEGNGSVVTTHTHSDNFDSATLSLEQAWHVSPAWMQDLKGEDQATASSSSQLEKLNQHFTDMHASRAKYFKAYSSVRDTQVGYWFNLREHPEIDQHEGADQEFLIIAKNFYNQNNLPKDLQQQVSQLLTQSRWDQHGYDDIERQGNELTLIRRQIKTAPEYNPEQHRPIAYPQRAKVVGPEGETIHVDEWGRIKVRFLFTRSDDHGHDGGAGSNDNDTDSAWVDVLTPWAGEGYGARFLPRIGEVVVIDFFDGNIDRPFVTGRIHEAQRSPTKFDVKGQLPDTKKLSGIRSQEINGSGFNQLRFDDTTGQISTQLQSSHAATQLNLGNLSHPKEQATSQGRGEGFELRTDAWGAVRAGKGMLISTYAQEQAIADHLEAAQAQSLLSQGYESMKMLSEVAAKQQTDALNVINRLPKFIQSLELKTTGQALNSTVNLFKEGINNDPIHALKDCGGFIQDIGALGGNAKGVVDEFNSFFSDAKDAVENLKAFIENVEEHGPDIVKGKLASIKDRIHKNPFESIQEVGKVLTNVETKDFDLMSTCGTFSKGSKLEVSPSKALSSLQGFMEGYTQGLESSSDTQQQEQGKIFRQALMLLASPNGIALTTPENIILQASQDIAESASGSINLSAQKNIIGHAQDKISLFAAQKGLRAYAAKGKLELQAQDDAIEAIAKKVIKLISTEDKIELTSPKEIVLTAGGSQLKINANGVFSTTGGKFESKAGQHLFTGGAKVSYEVPELPKNGPYAVDFLFASLAGNGIENAKIQLYEPDKKEIIWEGKTDLRGKSNLSLQNESKRYEALIGFDDWSSIFDDEDDYEEEHEEEFEIGEHGMQAEENNLEE Kraken2_NZ_CP077849.1 IMICODJL_40082 Prodigal:2.6 1139431 1141371 + VFG043573(gb|NP_219906) 60.4 7.68e-244 (dnaK) chaperone protein DnaK VF0713 Adherence; porin VFC0001 Adherence MAKIIGIDLGTTNSCVAVLEGDKVKVIENAEGARTTPSIIAYKDGEILVGQSAKRQAVTNPKNTLFAIKRLIGRRYEDQAVQKDIGLVPYKIIKADNGDAWVEVNDKKLAPQQISAEILKKMKKTAEDYLGETVTEAVITVPAYFNDAQRQATKDAGKIAGLDVKRIINEPTAAALAFGMDKKEGDRKVAVYDLGGGTFDVSIIEIADLDGDQQIEVLSTNGDTFLGGEDFDNALIEYLVEEFKKEQNVNLKNDPLALQRLKEAAEKAKIELSSSNATEINLPYITADATGPKHLVINVTRAKLEGLVADLVARTIEPCKIALKDAGLSTSDISDVILVGGQSRMPLVQQKVQEFFGREPRKDVNPDEAVAIGAAIQGAVLSGDKNDVLLLDVTPLTLGIETMGGVLTPIIEKNTTIPAKKSQVFSTAADNQPAVDISVYQGERKMAQQNKLLGNFQLGDIPPAPRGVPQIEVSFDINADGILKVSAKDKSTGKEQSIQIKANSGLSDAEIEAMIKDAEANAEEDRKFEELAKARNEADALISSSNKAVKDLGDKVAEDEKTAVNTAVSELEAATKENDVEAIKAKTEALQNILMPITQRAYEQAQQAGGAEGFDPNAFQGGDAGQQKADDGVVDAEFTEVKDDKK Kraken2_NZ_CP077849.1 IMICODJL_40154 Prodigal:2.6 1214962 1216437 + VFG037176(gb|WP_001081735) 100.0 0.0 (plc1) phospholipase C VF0470 Phospholipase C VFC0235 Exotoxin Contribute to the pathogenesis by aiding in the lysis of host cells, via cleavage of phospholipids present in the host cell membrane, and by degrading phospholipids present at mucosal barriers to facilitate bacterial invasion Lipolytic enzyme that catalyzes the cleavage of phospholipids MPDNFTDNPLAGFKQYRRANEQSGQPVSNDTLTCPAYDEKIDVTQPLYKGIANTMPDGGFLGTFKADIAQGKLPQVSWLVAPATYSEHPGPSSPVQGAWYIQEVLNVLTENPQVWSQTVLLVNFDENDGFFDHVPSPSAPSKDINGVVYGKTTLTDQQVSFEYFNHPAVATSKSQPETDGRVYGPGVRVPMYVISPWSRGGWVNSQVFDHTSILQFLEKRFDVQEPNISPYRRAVCGDLTTAFNFKTPNLLPVAELDGKKTKAEADAIRVAQELLPQVSVPSQQQFPQQEIGIRPSRALPYILHTSAKVDATQKTVKLMFSNTGKQAAVFHVYNRLDLTAIPRRYMVEAGKQLDDVWNTINGQYDLWVLGPNGFHRAFKGNLSQANQTQALPEIRVCVEECDANLYLKVRHDGNKTVKLNVKANAYLPNKTWVIETNSVEKELVWDMSEFGGWYDFTVTLADDATFSRRFAGRIETQEDSISDPYMGYLES Kraken2_NZ_CP077849.1 IMICODJL_40161 Prodigal:2.6 1221939 1224125 - VFG037852(gb|WP_001075965) 99.2 0.0 (ACICU_RS00395) polysaccharide biosynthesis tyrosine autokinase VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MNQQNTNTEDTIDLKELFFSLIAQWKLIALCVILSVVCALLYLRVTPDTYSVDALVQVEDSKGASAALLGDLSQMIEQKSPAQAEIEILKSRLVLGSVIKDLHLNIQVSSTENTFTHRLLSDTDYKTEYAKKSVLFKDGLKSFDIRQFEIPAYYLDKNLLLDFDKQSLRLTDPDTEEVILTVPLNQANSVTGPYGLWKVAIFTKDQFDSTYNIKKLSLPLAIKSISSDYSVEEKGKLTGILGLSYQGQDQEHITKVLNAILATYSAQNIERRSAESAQTLKFLDEQLPDLKKQLDDAERQFNKFRQQYNTVDVTKESELYLTQSITLETKKAELEQKQAEMAAKYTAEHPAMREINGQLAAINKQIGELNSTLKQLPDVQRQYLQLYREVEVKTQLYTALLNSYQQLRIAKAGEIGNVRIVDTAIEPVQPIKPKKLLVLILSVFVGGFIGTLIALLRNMLRTGIKDSGQIENELDLPVYATVPRSPIQESRIKILKKKKSIPILAVKNSDDIAIESLRSIRTAIHFALANAKNNIIMIAGPSPEVGKSFISTNLATIFAQGDKRVLLIDADMRRGYMHKYFDVDVKPGLSELLSGQADLQKVLHKTQVTNLDVITRGKSPTNPSEILSSNQFKELLEQLQSQYDHIIIDTPPVLAVTDGIIISQYTGVNLIVARYAKSQMKELELTVNRFEQAGVKVNGFILNDIQRASAGYGYGYNYAYAYKAQKED Kraken2_NZ_CP077849.1 IMICODJL_40162 Prodigal:2.6 1224145 1224573 - VFG037867(gb|WP_001165990) 100.0 2.46e-106 (ACICU_RS00400) low molecular weight phosphotyrosine protein phosphatase VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MQIKNILVVCIGNICRSPMAEYFLKQQYPQLNIESAGISGLIGHQADEKARLCMERLGIDMQPHIAKKLNAELIKKADLILVMSTNQQKHIEQTWPFAKGKTYRLGHWQNKNVPDPYQHEQAVFDETCQLIQQCVADWEPYI Kraken2_NZ_CP077849.1 IMICODJL_40163 Prodigal:2.6 1224578 1225678 - VFG037882(gb|WP_000872593) 100.0 5.25e-267 (ACICU_RS00405) polysaccharide biosynthesis/export family protein VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MKYCQFFSVLALSLSAASCAVTSGLQTYDIPSEGVYKTDLGTTVNVVKISQETLPAIQPAQIDYQRDYASLFKNQQTIYRLSPGDVLSIQLWAYPEITPPVSNISNEQSVQANGYPIDQSGYIQFPLVGRYKAAGKTLAQVNRELHNQLARFLKNPDVVVRVVSYEGQRFSVQGSVTKGGQFYLNDQPVSIYTALGMAGGVTTTGDNTYIQLIRNGRTYNLNTIDLEKAGYSLHKLLVQPNDTIYVSTRENQKIYVMGESGKNQALPMRDQGMTLTDALGESLGINPLSGSASRIYVVRTNPNDRTTEIYHLNLMSIGDFGLANQFRLRSNDVVYVDATGLTRWQRIVNQIIPFSNALYNIDRLGQ Kraken2_NZ_CP077849.1 IMICODJL_40164 Prodigal:2.6 1226034 1227308 + VFG037897(gb|WP_001165095) 100.0 7.86e-312 (tviB) Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MQIAKLKIAIIGLGYVGLPLAVEFGKKVPVVGFDIYQKRIDELKNGQDHTLEVSPEELKQAVHLKYTAHLDDLQNSNFFIVTVPTPIDDFKQPDLTPLIKASTSIGQVLKKGDVVVYESTVYPGATEEVCIPVLEKVSGLKFNQDFFAGYSPERINPGDKQHRVTNILKITSGSTPEVADYIDEVYNLIIEAGTHKAPNIKVAEAAKVIENTQRDVNIALINELALIFNKLDIDTEDVLKAAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQSIGLHPEIILAARRLNDRMGEHVATQLIKEMVKQRIQVVGARILVMGLSFKENCPDIRNTKIVDFIKALKEYDLDLDIYDPWVDDTEVQHEYGLAPIKELQQGLYDAIVIAVAHNQFKSMSAHEFHALGKEKHVLYDLKYVLDKSETDIRL Kraken2_NZ_CP077849.1 IMICODJL_40165 Prodigal:2.6 1227355 1228353 + VFG037912(gb|WP_000939040) 99.7 1.91e-245 (pseB) UDP-N-acetylglucosamine 4,6-dehydratase (inverting) VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MLQGSTILVTGGTGSFGNTFVPMTLEKYNPKKIIIFSRDEMKQWEMAKKFKDDKRVRFFIGDVRDKERLYRALDGVDYVVHAAATKIVPTAEYNPFECIKTNINGAMNLIDACIDKKVKGVVALSTDKASSPINLYGATKLASDKLFVAGNAYSGEHGTKFSVVRYGNVMGSRGSVIPFFMSIKDKGVLPITDDRMTRFMISLEQGVELVWHAFEDMVGGEIYVKKIPSMKVTDLAAVVAPEAKQEVVGIRPGEKLHEQMISVEDAYYTYEYPEHYKILPVINDWAETKERIKDGKRVPEGFHYSSDNNTEWMSPEDLQQWLIENAEKVGNI Kraken2_NZ_CP077849.1 IMICODJL_40166 Prodigal:2.6 1228355 1229515 + VFG037927(gb|WP_000470518) 100.0 2.31e-287 (pseC) UDP-4-amino-4, 6-dideoxy-N-acetyl-beta-L-altrosamine transaminase VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MFIPYGKQNINQADVDAVVQVLQSDFLTQGPQVPLFEKSVAELVGAKYAFAMNSATSALHVACLALGLKKGDVLWTSPITFVASANCALYCEADVDFVDIDPDTYNLSVDALKEKLEIAKKNNKLPKIVVPVHLCGQPCDMEKIHALSKEYGFSVIEDASHAIGGKYKERYIGSNQYSDITIFSFHPVKIITTAEGGMALTNNEDLAKKIDLLRSHGVTRNPEFMTKPSEGPWYYQQVELGYNYRMTELQAALGVTQLTRLETFVAKRHEIAKKYNELLKDLPLITPYQLPETYSGLHLYVIRLKLDELSKGRKEIFEILREKGIGVNVHYIPVHTQPYYQQLGFKQGDFPEAEAYYEAAISLPMFPDLTDEQIQYIYQTLKEVLV Kraken2_NZ_CP077849.1 IMICODJL_40167 Prodigal:2.6 1229518 1230210 + VFG037942(gb|WP_001175206) 100.0 6.849999999999999e-172 (pseF) pseudaminic acid cytidylyltransferase VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MQLAVIPARGGSKRIPRKNIKDFYGKPMIAWSIEAALKSECFDEVWVSTDDQEIADIAVKFGAKVPFLRPAHLSDDYATTADVMQHATQAFAQLQGQSPDFVCCLYATAPFVQVDDLKTGLQLLQSHPLDYAFSATTFAFPIQRAIKLNEDGNVEMFQPENFNKRSQDFEEAWHDAGQFYWGTAKAWLEKSVIFSNRSRIVELPRTRVQDIDTPEDWHRAELMAQLLLDV Kraken2_NZ_CP077849.1 IMICODJL_40168 Prodigal:2.6 1230265 1231311 + VFG037957(gb|WP_000666850) 99.7 1.45e-259 (pseG) UDP-2,4-diacetamido-2,4, 6-trideoxy-beta-L-altropyranose hydrolase VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MIRCLTIADALAQHGHESYFICRPHQGNLIEFVKQRGYMVHALSEPLFNMSLEFSEYQRWLGVTEQQDAQETLAVLIEYPVDWMIVDHYGLSAIWQQIIRPEVSRIVAIDDLANRKHDADIILDCGLANTPSDYAKLNQRVGYYLMGPCYALLRPEFRTKRLWLEQHPKTYNQEKLRILVNLGGVDKDNLTGTVLETLSNSPQEKHLSVTVVMGVNAPWKESVLQQAKKLPFSINILINANNMADLMAEHDLAIGAAGSTAWERCCLGLPTIMICMADNQKMIAKYLHDLGVAISLDQAEIHEKLLWALQQFDQEQLQLMHQKALSITDGIGVDLLLQTIFSEEFKEC Kraken2_NZ_CP077849.1 IMICODJL_40169 Prodigal:2.6 1231305 1231820 + VFG037972(gb|WP_000886731) 100.0 3.04e-130 (pseH) UDP-4-amino-4, 6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MLDQKNAQLRLLGHDDLEMVLQWRNHDDIRKWMVNSDIITLSDHFAWFERNKNRTDRLFYIFEYQQQPQGYISFVMIPNSTAYEWGFYIKPDAEKGMGQLLGNIALNHAFNKLGLEKVFGQVLSFNDKSLNFHRKMGFVQEGLLRKHFKDQRGEFDIYQFGLLRTEWLEGK Kraken2_NZ_CP077849.1 IMICODJL_40170 Prodigal:2.6 1231822 1232871 + VFG037987(gb|WP_000037963) 100.0 1.23e-261 (pseI) pseudaminic acid synthase VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MSKKITINNRDIGTDFPPYVIAELSANHNGRLETALKIIEEAKRCGADAIKLQTYSADTITLNSQNEEFMIRGGLWDGQSLYELYQKAQMPWEWHKPLFDHARALDITIFSSPFDRTAVDLLEDLNAPAYKIASFEAVDLPLIKYVASTGKPMIISTGMADKEEIGEAIQAAYDGGCKELVVLHCVSGYPAPAEDYNLLTMVDMAKSFNVPVGLSDHTLDNTTAITSVALGACLIEKHFTLDRNGGGPDDSFSLEPKELQQLCQGAKTAWQALGHVDYGRKSSEQGNAQFRRSLYFVKDLKAGDVIDESSIRSVRPGYGLPPKFYDELLGKKVTQDVSVNTPVKLEIIS Kraken2_NZ_CP077849.1 IMICODJL_40171 Prodigal:2.6 1232871 1234103 + VFG038002(gb|WP_000172211) 100.0 1.04e-277 (ACICU_RS00445) hypothetical protein VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MTLGLKIAPLINLSIRALTLLGKFILLFYMAKFLSAEEVGVYGLFVVLVSYSLYAVGFDFYTFSTRELVLKDKKEWGSFLKSQSFLIIFAYIVILPIILFLASYSIPTKWLFFLGLLIVLEHLNQELMRLLIIDKKTVMANNLLFIRSGLWCYLIIGCMIFALVENQLDSILDAWIVSDLIALIVGWLALKKGLVFSKSQIIQIEWLKSGLKICIPLLISTLILRAITTVDRLWLEQLEGLKVIAAYSLFIGLTNAIISFLETGVFSFIYPKMIQEKSNSENFRILVKKMFFQSLGLALLISIVLVISFPYFLHWIGKDIYYTYKHIFYVVLFANLIYCVSMVPHYILYAKHRDKQIVLSHILGLAIFILSTLVLIFNKVQVAVAYGLCCAFLSILIAKVVFSFKKNRFV Kraken2_NZ_CP077849.1 IMICODJL_40172 Prodigal:2.6 1234106 1235548 + VFG038017(gb|WP_001010045) 100.0 8.79e-310 (ACICU_RS00450) capsular polysaccharide synthesis protein VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MNFLILINSAPNYKYFFYELAKEIESRGHNIYFAIDSHRSKYLEPLPELDNNQNSFFFDSYLEKNFDKNLSVSHNNNQEYWGDYFYSDYDRFLTHDFNLNKDKNYWLNVKVSLDSFFEDIIKDKQIDFVLYENISNSFAYAAYLQCTKLGKKYIGLMGSRLPNHFEIQNSIVEEELKKLEILAQKPITQDEMEWFENYKKSIVDIQPDYMKQNGLDNVAISRIVKLNKFLKALRLLTIGFKYKHYYDYQFGNPFMVPIKAIRVNIKRYLNTKKSQKFYINNDELEICSSKERFYIYPIHFHPESSTSVLAPEYTNEYSNIINIANNLPFGTYLYVKDHKSAKGVQSYEFYKKVSSLPNVRLVNFDVNIKRLILKSLGVITVNSTAGYEALLLGKPVYLLGRVFYENFNNVYNLKSFRDIRDIRDILDFQFLDVKKDFIAYKKYVYKGVIFIDYGNRVNDKKRYFSELVDSIFLNINTDIE Kraken2_NZ_CP077849.1 IMICODJL_40174 Prodigal:2.6 1236866 1237477 + VFG038047(gb|WP_000994240) 100.0 1.69e-145 (ACICU_RS00460) hypothetical protein VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MNASLILSHKNIDHIYNLVQQILDSNFYIHINLKVNFVKIKKATSNIGNIFCVENRVDSKWARYSIVKDILNLMNYILQQDTRNKYFHLINSDDVISINEQVWDDSTIYMEYVGTGLFSRSKYFFIDSALSNILIKGGWFLYTLFFFIFLKREKDYRVNATFIIFVCFYFYENIFNGNLLLSIFLFMNFYNLLSKSYSLKNIG Kraken2_NZ_CP077849.1 IMICODJL_40175 Prodigal:2.6 1237482 1238306 + VFG038062(gb|WP_000515955) 100.0 3.5499999999999997e-205 (ACICU_RS00465) hypothetical protein VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MGKIAILIMAHKPIKYFEGLARDNQQVNFFVHMDIKTNFVNPEIKNLYFLKDELRVDVKWGGFSQVQATLNLLSFVFHNSDSEFFHVVSGEDVILSTNKNLSETLTWSNSNIFMELTDSPRHRYRVRFFAPHVETRWQRKLVGKLFTFSLKILDKIFITKKDFWFGSNWFSIRREELKIILNSITDRDISLFKHRLNPDEHFFQYIVVKAGLRNNISLKGNNRYIIFDKRYNNGNNPIYLNADQLLKLKNTCSHFFARKVDIDNQLKYYERVNF Kraken2_NZ_CP077849.1 IMICODJL_40176 Prodigal:2.6 1238306 1239139 + VFG038088(gb|WP_000493218) 86.9 9.37e-177 (M3Q_RS01495) glycosyltransferase VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MLQFSVLLSLYFKEKPEYLEKCFASIWDNQSLEPSEIVLVLDGSIGDELDACVQKWKLKIGDCLKVVALPQNVGLGKALNEGLKQCSYDWVFRMDTDDICTPDRFEKQVAFIKQNPDVVLFSGQVMEFDKDITDANVLKAVPITYEEIREFAQKRCPFNHMTVAYKRDVILGLGGYQHHLFMEDYNLWLRVIGNNYKVANLPDVLLYARVGNGMHARRKGFQYIKSEKQLLDLKKQLKLQNPLYANMLFLVRSAFRLLPANLLGTIYNTFLRKDIKK Kraken2_NZ_CP077849.1 IMICODJL_40177 Prodigal:2.6 1239152 1239772 + VFG038091(gb|WP_000826956) 100.0 1.63e-149 (ACICU_RS00475) sugar transferase VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MKRLVDIVISLIALTVLSPIFLIVAYKVRKNLGSPIFFYQERPGKDGKLFKMIKFRSMKDAFDAQGNPLPDEARITPFGQKLRSTSLDEMPQLINVLKGDMSVVGPRPMLKDFVALYSPEQARRLEVRPGMTGLAQVSGRNELDYEERFKCDVWYVDNHNIWVDFKIMFKTVKVMLKREGINAPGHVGPSLFKGNDTQENIDSSVK Kraken2_NZ_CP077849.1 IMICODJL_40178 Prodigal:2.6 1239711 1240673 + VFG038105(gb|WP_000591436) 100.0 1.81e-205 (galU) UTP--glucose-1-phosphate uridylyltransferase GalU VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MGHLYLKVMIPKKILILLLSKFLYLEIFLMIKKAVLPVAGLGTRFLPASKSIPKEMVTVVDRPAIEYVVREAVEAGIEQIILVTHSSKASIENYFDRNFELETTLEQKKKFDLLAEITQIVPEHVSVVSVRQPQPLGLGHAVLCAKSVVGQDDFAVLLPDVLVKDSSGQNDLSRMISRYNSSQAAQIMVEAVPDHLVDQYGIVDVKHSPNEGESIAMQGIVEKPAVGSAPSNLSVVGRYVLPAKIMQLLENTPKGAGNEIQLTDAIAMLQDTDIVEAYRMQGQTFDCGSKIGYLKAVLHYGIEHPKLGNDFKQLIQELKL Kraken2_NZ_CP077849.1 IMICODJL_40179 Prodigal:2.6 1240789 1242051 + VFG038119(gb|WP_000686134) 100.0 2.97e-314 (ACICU_RS00485) nucleotide sugar dehydrogenase VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MKIAVFGTTLHAGVMAALLAEYGNQIYWCTSVTCEENISILSYQDQEVNHYLNKQRKAGFLKESPFSEIPLDIEVYLFCFSPTQIELALKTVEKLSERPIVHPRLMINGSTFGLHGTNQLKQHLPKDEWVYFPDVIQEGNAINSVLNVKHVIVGVESSYAQDTMQELLRPFFRFSYQYLFMPILDAEFTKLSISGMLATRISYMNDLAMVAEKLGIDIANVKHGIAADTRIGAAYLSAGVGFGGENFSHDILTLSSTVSGTGAKSRLLEQVWAINEQQKEILFRKLWNYYHCDLSGKTVAIWGASFKENTPSTHNSPIHILLAALWAQGVKVRLHDPQALDEIATTYGDREDLVLCADQYEAAQGAHALCLVTAWKQYWSPDFKQLQQVMQHPLILDGRNIYDPAYVKAKGFAYEGVGRL Kraken2_NZ_CP077849.1 IMICODJL_40180 Prodigal:2.6 1242048 1243718 + VFG038132(gb|WP_000045495) 100.0 0.0 (pgi) glucose-6-phosphate isomerase VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MSKSIEKFPKELVSPIAQLHSLVEKNSKLHIKELFAAEQDRFQNYSVKFDQLVFDYSKHRITKSVLEQLFALAKTKQLTHWIERLFSQDKVNCTEQRAAMHWALRLPSEYSKFPELTKQVHNQLQRMYALVEKIHAGQYRGATGEVIQDVVNIGVGGSDLGPQMVTHALCDFKVKTAKPLNVHFVSTMDGSQLSDLLHQLRPETTLFIISSKSFGTIDTLSNAQTVRQWLEKALGKHDRVVKSHFIGVSTKAEKMTEWGIAPDNQLLLWDWVGGRYSLWSCIGFPIALTIGIDGFQQLLAGAHAVDEHFQNTGFEQNIPVLMALLGIWNNNFLNIQTHAVLPYDGRLKYFAAYLQQLEMESNGKSVQRDGQKVELDTCPIVWGEVGPNAQHAFYQLLHQGTQAVSCDFIAPIQRYNADHFTYVENAEALIEQHHLALSNCLAQSRLLAFGNEALDSAELKNLPIYKQYEGNQPSSTLLLKELNPYSLGMLIALYEHKVFVQSVIWNINPFDQWGVEKGKQIADQLLPILNGAQNDLSTLDASTRGLIKILLGKVDG Kraken2_NZ_CP077849.1 IMICODJL_40181 Prodigal:2.6 1243711 1244727 + VFG038121(gb|WP_001062922) 100.0 6.9800000000000004e-251 (galE) UDP-glucose 4-epimerase GalE VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MAKILVTGGAGYIGSHTCVELLEAGHEVIVFDNLSNSSKESLNRVQEITQKSLTFVEGDIRNSGELDRVFREHVIDAVIHFAGLKAVGESQEKPLIYFDNNIAGSIQLVKSMEKAGVYTLVFSSSATVYDEANTSPLNEEMPTGMPSNNYGYTKLIVEQLLQKLSVADSKWSIALLRYFNPVGAHKSGRIGEDPQGIPNNLMPYVTQVAVGRREKLSIYGNDYDTIDGTGVRDYIHVVDLANAHLCALNNRLQAQGCRAWNIGTGNGSSVLQVKNTFEQVNGVPVAFEFAPRRAGDVATSFADNARAVAELGWKPQYGLEDMLKDSWNWQKQNPNGYN Kraken2_NZ_CP077849.1 IMICODJL_40182 Prodigal:2.6 1244772 1246142 - VFG038133(gb|WP_000209956) 100.0 0.0 (BJAB07104_RS00555) phosphomannomutase/phosphoglucomutase VF0465 Capsule VFC0258 Immune modulation A. baumannii pan-genome was shown to include a highly diverse repertoire of gene sequences. In particular, capsule gene cluster is highly variable. The cluster at the K locus often contains either capsule export genes (wza, wzb, and wzc) or genes for simple sugar synthesis (galU, ugd, gpi, gne1, and pgm), which flank a central variable region that would be required for the synthesis of a specific monosaccharide. Plays an important role in protecting bacteria from the host innate immune response MTTLTCFKAYDIRGKLGTELNEEIAYKIGRAYGQIYKPKTVVVGCDIRLSSEALKQATIRGLNDAGVNVLDLGMTGTEEVYFAAFHLDVQGGIEVTASHNPMDYNGMKLVRENARPISADTGLKEIQALAETNNFEEVSQKGTTQSYNILPEFVDHLLTYIEPAKIRPLKLVVNAGNGAAGHVIDAIEEKFKALNVPVEFIKIHHEADGTFPNGIPNPILIENRDSTRNAVLEHKADMGIAWDGDFDRCFLFDEKGQFIEGYYIVGLLAQAFLIKQSGEKIVHDPRLVWNTFDIVDEYKGVAVQSKSGHAFIKDVMREHNAVYGGEMSAHHYFRDFAYCDSGMIPWLLTIALLSETGQSLSTLVENMIAKFPCSGEINFKVADTQTTIQKIFDFYANQNPQIDRTDGVSLDFGTWRFNVRASNTEPLLRLNIESRADRQAQPMQHYVDELTGLIQN Kraken2_NZ_CP077849.1 IMICODJL_40221 Prodigal:2.6 1290591 1291142 - VFG038194(gb|WP_002000467) 100.0 2.3200000000000002e-132 (abaI) N-acyl-L-homoserine lactone synthetase VF0471 Quorom sensing Autoinducer-receptor mechanism VFC0271 Biofilm AbaI protein belongs to LuxI autoinducer synthases family. The consensus pattern of the said family is [LMFYA]-R-x(3)- F-x(2)-W-x-[LIVM]-x(6,9)-E-x-D-x-[FY]-D; AbaR belongs to LuxR family, interacting with the AHL molecule and further controls the gene expression of AbaI Quorum Sensing plays a significant role in biofilm formation. The QS circuit of A. baumannii consists of two components, AbaI inducer and its cognate receptor AbaR which is homologous to the typical LuxI/LuxR system found in other Gram-negative bacteria; QS-regulated phenotype includes OmpA, AdeFGH effux pump, PNAG, type I pili, etc.) and biofilm formation MNIIAGFQNNFSEGLYTKFKSYRYRVFVEYLGWELNCPNNEELDQFDKVDTAYVVAQDRESNIIGCARLLPTTQPYLLGEIFPQLLNGMPIPCSPEIWELSRFSAVDFSNPPSSNSQAVSSPVSIAILQEAINFAREQGAKQLITTSPLGVERLLRAAGFRAHRAGPPMTIDGYSMFACLIDI Kraken2_NZ_CP077849.1 IMICODJL_40223 Prodigal:2.6 1292397 1293113 + VFG038203(gb|WP_000446790) 100.0 1.54e-172 (abaR) DNA-binding HTH domain-containing protein VF0471 Quorom sensing Autoinducer-receptor mechanism VFC0271 Biofilm AbaI protein belongs to LuxI autoinducer synthases family. The consensus pattern of the said family is [LMFYA]-R-x(3)- F-x(2)-W-x-[LIVM]-x(6,9)-E-x-D-x-[FY]-D; AbaR belongs to LuxR family, interacting with the AHL molecule and further controls the gene expression of AbaI Quorum Sensing plays a significant role in biofilm formation. The QS circuit of A. baumannii consists of two components, AbaI inducer and its cognate receptor AbaR which is homologous to the typical LuxI/LuxR system found in other Gram-negative bacteria; QS-regulated phenotype includes OmpA, AdeFGH effux pump, PNAG, type I pili, etc.) and biofilm formation MESWQEDLLSAFLVVKNEYQLFEIVKSTASRLGFDYCAYGMQSPLSIAEPKTIMLNNYPEAWQKRYVERQYVKIDPTVQHCMVSLQPLVWSSQSAKTQAEKDFWEEARSYGLNVGWAQSSRDFIGTRGMLTLARSNDQLSEKEQKAQYTNMYWLTQTVHSSIAKIVNDVEFAKFNLYLTNREKEALRWTAEGKTSAEIAQILGVTERTVNFHLSNSMQKLNVNNKISAAIRAVMLGLL Kraken2_NZ_CP077849.1 IMICODJL_40277 Prodigal:2.6 1346579 1347733 - VFG050502(gb|WP_000755281.1) 100.0 8.730000000000001e-291 (tsaP) LysM peptidoglycan-binding domain-containing protein VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MKKVFNGMVNFHALGIKKHLLALALCTGVAIGTIAEVHATSPNHNPPSLKSNAPNVYVVKRGDTLWDISGHFLNKPWRWPEIWASNQHVKNPHWIYPGDRLLLCSLDGRPLVGKDEGDGCVGIIRRYTGQTTNLQPQVRVEALNNSVPVIPLEHIKQWLENSTILPADSITNTPYIVGTADQRVLAGKGQTIYARGQGLINGQRYAVYREGEPYYFTDNKGKKHSLGIELLQVASGVAVSSEKDITTLELTDSYNAEVRRGDRVMPEEQATLPTLFYPVDAKQVTDGGKIIRVMGSIGRAAKNSVVTLDRGTTQGIQVGQVFDITQQGESIRDPKTKEVIQLPGQQIGSLMVFRTFDQLSYAYVLESDLPIKVGSSIQPPQFND Kraken2_NZ_CP077849.1 IMICODJL_40354 Prodigal:2.6 1427568 1428989 - VFG050696(gb|WP_000840549.1) 100.0 0.0 (pilR) sigma-54 dependent transcriptional regulator VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MAEQQPLVLLVDDEEDLCLLMQMTLARMGIKTHLAYRVEQAKQLFTQFHYDACLTDLNLPDGSGIDLVKHVSQNYTNTPIAVLTAYGNMDIAIAALKAGAFDFVSKPVNQVHLDQLLQKALNRQKVEHDAAENALENKLLIGRSLPIQQLRIAIKKIARSQAPVFVTGESGTGKEVVANLVHRLSNRSEGPFIAINCGAIPTELMESELFGHKKGSFTGATQDKQGLILSAHGGSLFLDEIAELPLSMQVKLLRAVQEKKIRPVGSDQEIDVDFRVISASHQDLDLLVRQGKFRQDLFFRIHVMDLILPPLRERGEDVLLLANHFIQKICMEWETPPKQLTEAAETYLLQQHFPGNVRELRNMIERAITLSEDTTIDVSHLHPAPLRANISNPFASAAQSIQTTVAAPQVVKKLPSEGLERYLENIEKDILLNALNMTHWNRTLAAKKLGMTFRSLRYRLKKFGLDTETEQEV Kraken2_NZ_CP077849.1 IMICODJL_40355 Prodigal:2.6 1429014 1430582 - VFG050682(gb|WP_001160333.1) 100.0 0.0 (pilS) PAS domain-containing sensor histidine kinase VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MQFPLNSSLSHTIFRLGTWYGLYRLIIAVSLNIILVLTDAQTDNSLQQPALYSYTLLGYSLLSLVQLLCFKFIATQATRQLILFFIVDIICLSLLTFSVGEPNLQLSLLYVIAIFTSAILLSARMSLLITLLAVIAVIYQRFVGSLFDYNNLNTIGNSALLAFLFFVVHGIGQIAVQRFKLLEALTFHQSIELYQLQNINRYILEQIEEGYLVLDENYDIVVSNPAACSLLGIPPQFANEKYPLAKWHADLFEILKFGDLKEGDRFIFESRLSAYSINIKVQHLLVPQQTLTLLILQDAQQINQQAQQLKLAALGQLSASIAHEIRNPLAAIVQANELLKDSDPEQQNTLRHMIGKQTKRIDSIVQDTLGLARSERTHPIQIDVKHFIVTLLEEDLFDVKHSIQLKISDSSLKFLFDEKQLRQVMINLVRNALRHNAPDSPYITINIHSQTNKIYIDVIDYGEGVSKRDISQLFKPFFSTEINGTGLGLYLSHSFCEANHAKLTYVEQKQGACFRIECPIIY Kraken2_NZ_CP077849.1 IMICODJL_40357 Prodigal:2.6 1431441 1432487 + VFG038249(gb|WP_003384760) 100.0 4.8000000000000004e-238 (pbpG) D-alanyl-D-alanine endopeptidase PBP7/8 VF0468 PbpG Penicillin-binding protein VFC0258 Immune modulation Penicillin-binding proteins (PBPs) are most commonly associated with binding to and inactivating b-lactam antibiotics; PBPs also participate in the final steps of the biosynthesis of the peptidoglycan layer and thus contribute to bacterial cell stability MKNSKKSLMHVLSMSILLSLSSTSFAELVNNPSSGSTGTASLNWSAADASQLLNDEDDEPTPQGSTSVTTTLRGSNAPRVITSTPKVAPIRDTVGYNAQPSVSARAALVMDAQTGEVLYSKNTNASVPIASITKLMTAVVTADARLNMSEEITLEQIDFAGAGGKNSSSTLRVGDKMNRAEVLLFALMKSENPAAAALARTYPGGRAAFVAAMNAKARALGMNATHYYESTGLDPRNVSSARDLGILASTASQYGLIRQFSTTPTYDFNLGYRVLKSNNTNALVRNGGWNINLSKTGYINEAGRCVVMHTTVNSRPAVIVLLGEPSTQARNNDATNLLGWLSNLPKRI Kraken2_NZ_CP077849.1 IMICODJL_40381 Prodigal:2.6 1456833 1457762 + VFG013198(gb|WP_011608203) 60.3 2.19e-124 (hemC) hydroxymethylbilane synthase VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MLEFMKTLKIATRQSPLALWQAEHIRARLQELHPDLTVELVKFVTQGDKILDTPLAKIGGKGLFVKELEAALLDGRADLAVHSMKDVPMALPEGLTLAVICEREDPLDAFVSNQFEKFADLPQGAKVGTSSLRRKSQILKQRPDLQIIDLRGNVGTRLAKLDDGQYDAIILASAGLKRLGLAERIRHCIEPSVSLPAVGQGALGLECRADDQEVLTLIQPLLHPETDVCVRAERAFNAYLEGGCQVPIAGYATLQDGKIHIEGRVGSVDGQTLLRAELTDEANNAQQLGENLARNLLDQGAGDLLKALY Kraken2_NZ_CP077849.1 IMICODJL_40387 Prodigal:2.6 1461887 1462630 + VFG050712(gb|WP_000730343.1) 100.0 7.99e-184 (gspN) type II secretion system protein N VF1335 T2SS VFC0086 Effector delivery system Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB Secretes multiple effectors that were shown to be required for virulence in vivo, including the lipoyl synthases LipA and LipH as well as the protease CpaA MKKKSKQWKWWFFALIAFLIFIILQIPATWLISKFSKNNQTVHNVSGNIWQGQADWHRGALRGTIHWKTRPLDLLLLRFAADVDIHSGNTQLTGIMAYGFGKKVIVRDMNGQIAPETLKQIVNWQWPVNSIQLKDIQFNYKKEQGFAAVDGQLHWGGGALIYNIGDRQDRMNMPSLSGQLTDQNGQLQVDIRDQRNQKMANLLLDANMMLDVQLTQRLLLNVPSYDGKAGLDTFVISSRQPLLQGGN Kraken2_NZ_CP077849.1 IMICODJL_40388 Prodigal:2.6 1462630 1463466 + VFG050727(gb|WP_000870033.1) 100.0 8.289999999999999e-197 (gspC) general secretion pathway protein C VF1335 T2SS VFC0086 Effector delivery system Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB Secretes multiple effectors that were shown to be required for virulence in vivo, including the lipoyl synthases LipA and LipH as well as the protease CpaA MKVWIDKLQQLQWQKLDRLSVVVLAILILWLCWKLASFFWLVIAPPQLMQFDRVELGSQQPQIPNISTFSLFNEPSANAAQESVNLELQGVMVGYPNRFSSAVIKIDNTAERYRVGETIGSTSYQLAEVYWDRVVLSQGNGSTRELQFKGLPNGLYQPMTPDASQQSATPSQSTEPMNTAQQALGQAIQQMQGNREQYLRDMGVSGNSGEGYEVTERTPTALRNKLGLRPGDRIVSLNGQTVGQGQTDVQLLEQARRAGQVKIEIKRGDQVMTIQQNF Kraken2_NZ_CP077849.1 IMICODJL_40389 Prodigal:2.6 1463508 1465784 + VFG050742(gb|WP_001196426.1) 100.0 0.0 (gspD) general secretion pathway protein D VF1335 T2SS VFC0086 Effector delivery system Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB Secretes multiple effectors that were shown to be required for virulence in vivo, including the lipoyl synthases LipA and LipH as well as the protease CpaA MALLNHQRPLWALLAAAPLIATVSSSAYAQTWKINLRDADLTAFINEVADITGKNFAVDPRVRGNVTVISNKPLNKDEVYDLFLGVLNVNGVVAIPSGNTIKLVPDSNVKNSGIPYDSRNRVRGDQIVTRVIWLENTNPNDLIPALRPLMPQFAHMAAIAGTNALIVSDRAANIYQLENIIRNLDGTGQNDIEAITLQSSQAEEIITQLEAMSATGASKDFSGARIRIIADNRTNRILIKGDPQTRKRIRHMIEMLDVPSADRLGGLKVFRLKYASAKNLSEILQGLVTGQAVSSSNNSNNSSNSSNPINSLIGNNQNSGSNTSGSNGASISTPAINLNGNSNSSNQNNITSFNQNGVSIIADNAQNSLVVKADPQLMREIESAIQQLDVRRQQVLIEAAIIEVSGDDADQLGIQWALGDLSSGIGLLSFSNVGASLSSIAAGYLSGGSAGAASAIANGANKGNGATLGLGNFDNSRKAYGALIQALKTNTKSNLLSTPSIVTMDNEEAYIVVGQNVPFVTGSVTTNSTGINPYTTVERKDVGVTLKVVPHIGEGGTVRLEVEQEVSAVQDSRGQAADLVTSKRAIKTAVLAEHGQTVVLGGLVSDDTSLSRQGIPGLSSIPYVGRLFRSDNRSNVKRNLLVFIHPTIVGDANDVRRLSQQRYNQLYSLQLAMDKNGNFAKLPEQVDDIYNQKMTPPSIASKPKNYQQVPSGGKSSTITTPVAVEPTVQKQTLQLPDPEINRTKNTVTTTTLRPSTAP Kraken2_NZ_CP077849.1 IMICODJL_40397 Prodigal:2.6 1469470 1470660 + VFG046459(gb|WP_004287053) 79.2 9.9e-234 (tufA) elongation factor Tu VF0460 EF-Tu VFC0001 Adherence Surface-expressed elongation factor-Tu (EF-Tu) mediates attachment by interacting with host cell nucleolin MAKAKFERNKPHVNVGTIGHVDHGKTTLTAAIATICAKTYGGEAKDYSQIDSAPEEKARGITINTSHVEYDSPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVCAATDGPMPQTREHILLSRQVGVPYIIVFLNKCDLVDDEELLELVEMEVRELLSTYDFPGDDTPVIRGSALAALNGEAGPYGEESVLALVAALDSYIPEPERAIDKAFLMPIEDVFSISGRGTVVTGRVEAGIIKVGEEVEIVGIKDTVKTTVTGVEMFRKLLDEGRAGENCGILLRGTKREEVQRGQVLAKPGTIKPHTKFDAEVYVLSKEEGGRHTPFLNGYRPQFYFRTTDVTGAIQLKEGVEMVMPGDNVEMSVELIHPIAMDPGLRFAIREGGRTVGAGVVAKVTA Kraken2_NZ_CP077849.1 IMICODJL_40447 Prodigal:2.6 1520796 1521656 - VFG050484(gb|WP_001152285.1) 100.0 1.5999999999999998e-198 (gspO/pilD) A24 family peptidase VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MQDIIAYFIQNLTALYIAVALVSLCIGSFLNVVIYRTPRMMEQDWQQECQMLLNPEQPIIDHERLTLNKPASSCPACQQPIRWYQNIPVISWLVLRGKCGHCQHPISIRYPAIELLTMLCSLVVVMVFGPTIQMLFGLILTWVLIALTFIDFDTQLLPDRFTLPLAALGLGINTFNIYTSPNSAIWGYLIGFLCLWIVYYLFKVITGKEGMGYGDFKLLAALGAWMGPLMLPLIVLLSSLIGAIIGIILLKLRNDNQPFAFGPYIAIAGWVAFLWGDQIMKIYLGG Kraken2_NZ_CP077849.1 IMICODJL_40448 Prodigal:2.6 1521656 1522882 - VFG050470(gb|WP_000279216.1) 99.8 3.1e-278 (pilC) type II secretion system F family protein VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MAVKKAQMMPTFAYEGVDRKGVKIKGELPAKNMALAKVTLRKQGVTVRNIREKRKNILEGLFKKKVTTLDITIFTRQLATMMKAGVPLVQGFEIVAEGLENPAMREVVLGIKGEVEGGSTFASALRKYPQHFDNLFCSLVESGEQSGALETMLDRVAIYKEKSELLKQKIKKAMKYPATVIVVAIVVTIILMVKVVPVFQDLFASFGADLPAFTQMVVNMSKWMQEYWFIMIIAIGAVIAAFLEAKKRSKKFRDGLDKLALKLPIFGDLVYKAIIARYSRKLATTFAAGVPLIDALESTAGATNNVIYEKAVMKIREDVATGQQLQFAMRVSNRFPSMAIQMVAIGEESGALDSMLDKVATYYENEVDNAVDGLTSMMEPLIMAILGVLVGGLVIAMYLPIFQMGSVV Kraken2_NZ_CP077849.1 IMICODJL_40449 Prodigal:2.6 1522912 1524624 - VFG050457(gb|WP_001274990.1) 100.0 0.0 (pilB) type IV-A pilus assembly ATPase PilB VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MSALHTSPKFTGFFRRLVEEKHVSAATMQTALDAAKRAKQDTVAYLIEEVHLSPSLLAETISAEFAEPYFDLDVYDTSQIPKDLVDQKLILKHRILPLIQRGQILYVATSNPSNIEAIDAIRFNSKLLVEPVIVEHHKLEKVLGQHFAEESSFDFNDEEFDLDVNLDGPTTQEDEEEAPQGDEAPIVKYINKLLIDAIRMGASDLHFEPYEKSYRVRYRVDGMLRQIANPPLQLANRLASRLKVMSQMDISEKRVPQDGRIKLKLSKSKAIDFRVNSLPTLFGEKLVLRILDPSSAMLGIDALGYEEDQKALFMEALDKPQGMLLITGPTGSGKTVSLYTGLNILNTESSNISTAEDPVEINLEGINQVNVNPKVGLTFAAALKSFLRQDPDIIMVGEIRDLETAEIAIKAAQTGHMVMSTLHTNSAPETLTRLRNMGVPSFNIATSVNLVIAQRLARRLCSQCKIPADIPKQSLLEMGFTEQDLAHPDFRVFQPVGCPECREGYKGRVGIYEVMKVTPEISKIIMEDGNALEIAAASEKLGFNNLRRSGLKKVMQGVTSLQEVNRVTSE Kraken2_NZ_CP077849.1 IMICODJL_40488 Prodigal:2.6 1573308 1574513 + VFG050787(gb|WP_001112089.1) 100.0 3.4e-267 (gspF) general secretion pathway protein F VF1335 T2SS VFC0086 Effector delivery system Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB Secretes multiple effectors that were shown to be required for virulence in vivo, including the lipoyl synthases LipA and LipH as well as the protease CpaA MPAYQFTAIDASGKQQKGVLEGDSARQIRQQLRDKAWTPISVDPVEQKDKHQSHGLFQKKFSAYDLALMTRQLSVLVAAAIPLEEALRAVSRQSEKAHVQNLLLSVRSKVLEGHSLAQGMQQSGRFPDLYIATVAAGERSGHLDLILDQLSDYTENRFAMQKKVQGAMIYPIILMLMSFGIVMGLMTYVVPEIVKTFDQSKDALPWITVALMKASDFIRHAWVFIILFAIVGVVAFVRFLKTTAGHYAFDRLTLKLPLFGKLSRGINAARFASTLSILTRSGVPLVDALKIGAAVTNNWVIRDSISQAAERVTEGGNLGTQLERSGYFPPMMVQMIRSGEASGELDRMLERASTMQDREVTTFISTLLALLEPLMLVLMASIVLVIVIAVMLPIVNMNNMI Kraken2_NZ_CP077849.1 IMICODJL_40489 Prodigal:2.6 1574537 1575118 + VFG050802(gb|WP_000865310.1) 100.0 5.2799999999999997e-135 (gspG) general secretion pathway protein G VF1335 T2SS VFC0086 Effector delivery system Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB Secretes multiple effectors that were shown to be required for virulence in vivo, including the lipoyl synthases LipA and LipH as well as the protease CpaA MKVKNIQSETAMKQHSESVVSNQFEPTCHSEHSSVSDVCSSSAFGLATRSSRARMKRASGFTLIEVMVVIVILGVLAALIVPNVMGRSEKAKIDTTQITLKGVAGALDQYKLDNGHFPTMQEGGLDALINQPATAKNWMPGGYVKGGYPKDSWKNDIQYVVPGKDGHPFDLYSFGADGKEGGEGNDADIYYQP Kraken2_NZ_CP077849.1 IMICODJL_40546 Prodigal:2.6 1630884 1632248 - VFG050428(gb|WP_000128073.1) 100.0 9.33e-301 (fimV) hypothetical protein VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MTAYNKLKIAIFTIMSSPSIYAITLDPIQIQSAPGELLYAEMNFQQADPNTPLQVSLATQDDLNGLGVTHQPPGNLNFYTRQNGQGSGVIVITSSRPIIDPELNIVVKVSEGNATRLQHIKTVLKPSPIKKAAMNESPLSPQFIVNEKDIALNLPESTQYTSTENTSTVAETTSNEHNLNISTGTAPALNSSSPAPVAPFTEKPSTQTLQPTIATMNTESSAVEKQPSTSLKSSDGNQTTTVKKAAQSKTAQQKNVLSKNTPKKQKISAYKGPAPTGKYVVQRNESLWSIANRIAAQTKQPVAKIMRDIQAQNRHAFIQGDVNRLRQGSSLNLTTNTTKASHLKPKSSEAHLAKPSSGRAKYRLQQAEMSIVAENSPNSAHGSAKKSTQQSQNNTELAVKVMTTRKKTVTLQRNVTKLNQTLSLKDQRIQLLNARLAELQQQLQAQQQTHKQKH Kraken2_NZ_CP077849.1 IMICODJL_40550 Prodigal:2.6 1636859 1637959 - VFG037777(gb|WP_000867091) 100.0 9.47e-270 (lpsB) glycosyltransferase family 4 protein VF0466 LPS VFC0258 Immune modulation LpxM dependent acylation of lipid A is essential for A. baumannii desiccation survival, a key resistance mechanism for survival in hospital environments Evasion of the host immune response, triggering the host inflammatory response MKVMQLLPELNSGGVERGTLEIARALVAQGHQSLVVSNGGRLVSQLEAEGSTHLTLPIHKKSLSSLWQIRPLRQLIEEHQPDIVHVRSRVPAWLTHFALRKIPANKRPHLISTVHGFYSVNRYSAIMTQAEKVIAVSDSVVKYITDHYKNCPPQDIVRIYRGIDPAAFPHNYQPSAQWFNQVFNDFPELENKFLLCLPGRITRLKGHESLIELMQKLGEQYPQLHAVVVGGADVKKQAYLSELQNTIQSKGLADKITFVGHRSDIREWLAFSDIVLSLSNQAETFGRTALEALSVGTPVIGWNRGGVAEILSHVYPQGLVEAENEKALVETVKNHIEQPQTVAPVTMFSLKDMCDQTLELYQSVLK Kraken2_NZ_CP077849.1 IMICODJL_40551 Prodigal:2.6 1638225 1639160 - VFG037762(gb|WP_000078878) 100.0 3.4099999999999996e-242 (lpxL) lauroyl acyltransferase VF0466 LPS VFC0258 Immune modulation LpxM dependent acylation of lipid A is essential for A. baumannii desiccation survival, a key resistance mechanism for survival in hospital environments Evasion of the host immune response, triggering the host inflammatory response MSQKQPYTPGEFQWSFLLPKYWGVWIAITFLMLLAILPWAIQWRLAHGLANLAWKYLKSRRKTTIRNLEVCFPEWTPEKVQQQAKQVFVDMMLGIFETLNAWYKPYWFKNRVTIEGLEHITNAQAQGKGVLLLGTHSTLLDAGGYVCAQYFEPDVVYRPQNNPLLDMLIYRCRGTIYKAQIDHDDMRGLIRHLKEGDAIWYSPDQDFGLKQGIMAPFFGVPAATVTAHRRLLKISKAVAVPLYFYRHGDVQDPKYHILIEPAVDNMPSEDEVDDATRVNKIIENQLRIAPTQYMWFHRRFKTRPEGYEEIY Kraken2_NZ_CP077849.1 IMICODJL_40598 Prodigal:2.6 1683875 1684480 + VFG000077(gb|NP_465991) 67.0 2.7699999999999998e-92 (clpP) ATP-dependent Clp protease proteolytic subunit VF0074 ClpP VFC0282 Stress survival 21.6 kDa protein belongs to a family of proteases highly conserved in prokaryotes and eukaryotes Serine protease involved in proteolysis and is required for growth under stress conditions MYVPTIENALVPVVVEQSSRGERSFDIYSRLLRERVIFLTGEVEDNMANLIVAQMLFLEAENPDKDIHLYINSPGGSVTAGMAIYDTMQFIKPDVVTYCMGQAASMGAFLLNAGAKGKRYCLENARVMIHQPLGGFRGQASDIEIHAREILFIKERLNRLMAEHSGQDYDTIARDTDRDNFMTAQAAKEYGLVDQVLSKRP Kraken2_NZ_CP077849.1 IMICODJL_40620 Prodigal:2.6 1711357 1712157 + VFG050414(gb|WP_002027454.1) 100.0 1.08e-186 (pilF) type IV pilus biogenesis/stability protein PilW VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MSTPKLKIMLCMGVAVALLTSGCQTSQTVKKDPEKAVKVRTQLAAEYIRSGDLDSAKRSLDQALSVDSRDATANMMMGILLQQEGSKPNLEKAEHYFKRAISSEPDNAQARNNYGTYLYQMERYNDAIEQFRIAGATLGYDQRYQALENLGRIYLKLGDIASAEKTFKQALLANRDSYISMLELAEIFYLQQQIPAATQMYEQYVRTVGQKNQGARALWIGLRVARANADKMGMQVLVNQLRALFPESPEYQRYLQLQYSTEAVWK Kraken2_NZ_CP077849.1 IMICODJL_40730 Prodigal:2.6 1828075 1829565 + VFG050757(gb|WP_001166319.1) 100.0 0.0 (gspE1) general secretion pathway protein E VF1335 T2SS VFC0086 Effector delivery system Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB Secretes multiple effectors that were shown to be required for virulence in vivo, including the lipoyl synthases LipA and LipH as well as the protease CpaA MQILKQIQVPYSFAKRHGVLFRYDGDQVFIVRRQNTEKIALQEARRILGKPAHYQLCTEQEFNSLLSTSYAGDTGESQQVAAGLEDHPDLLSLADQVPETEDLMDQEDDAPIVRLINALLSEAIRVGASDIHIEAFEKKLSVRLRVDGQLREIVQPRRELAPLLVSRIKVMAKLDIAEKRVPQDGRISLRLAGREVDVRVSTLPSSHGERVVMRLLDKQAGRLNMTHLGLMANDYERLTQLVHRPHGIILVTGPTGSGKTTTLYAALSDLNDNTRNILTAEDPIEYQLEGIGQTQVNTKVDMTFARALKAMLRQDPDVVMVGEIRDLETAEIAVQASLTGHLVLSTLHTNTAIGAVTRLKDMGIEPFLLSSSLIGVVAQRLVRTLCPHCMTWREADTFEKQVFQHIFHEPSLKLPEAQGCDQCSHLGFNGRTAIYEIVPIDEPMRRLIHGNAAEFELENHARQYSGSIRDDGLRKVLSGKTTLEEVLRVTNEASEA Kraken2_NZ_CP077849.1 IMICODJL_40766 Prodigal:2.6 1863783 1864469 + VFG046604(gb|WP_012280804) 64.7 4.18e-97 (rpe) ribulose-phosphate 3-epimerase VF0543 Capsule VFC0258 Immune modulation Group 4 capsule; high molecular weight (HMW) O-antigen capsule A polymer of the tetrasaccharide repeat, 4)-a-D-GalNAcAN-(1-.4)-a-D-GalNAcAN-(1-.3)-b-D-QuiNAc-(1-.2)-b-D-Qui4NFm-(1-, which is identical to F. tularensis O-antigen subunit; F. tularensis synthesizes an O-antigen capsule containing approximately 125 to 300 or more O-antigen repeating units Providing a stealth shield that prevents the host immune system from detecting this potent pathogen MSKPYLIAPSILSADFARLGEDVDKVLAAGADVVHFDVMDNHYVPNLTFGAGVCKALKNYGITAPVDVHLMVSPVDRIIGDFLEAGADIITFHPEASHHIDRSLQLIKSGGAKAGLVFNPATPLHYLDYVLDKVDQILLMSVNPGFGGQKFIPMTLEKLREARKIIDASGRDIRLEVDGGVGPANIREIAEAGADMFVAGSAIFGQPDYKVVIDQMRAELAKVGSVDA Kraken2_NZ_CP077849.1 IMICODJL_40828 Prodigal:2.6 1939261 1939977 + VFG038216(gb|WP_000076440) 100.0 3.49e-169 (bfmR) biofilm-controlling response regulator VF0463 BfmRS VFC0301 Regulation Two-component system: BfmS sensor kinase acts as a BfmR phosphatase to negatively regulate BfmR activity in certain conditions Controls biofilm formation and cellular morphology; participates in cell adhesion, resistance to serum killing and antibiotic susceptibility Activates the expression of the usher-chaperone assembly system responsible for the production of pili needed for biofilm formation on polystyrene surfaces; inactivation of bfmS may affect the regulatory process and/or translational modification of OmpA leading to loss of OmpA-mediated pathogenesis MSQEEKLPKILIVEDDERLARLTQEYLIRNGLEVGVETDGNRAIRRIISEQPDLVVLDVMLPGADGLTVCREVRPHYHQPILMLTARTEDMDQVLGLEMGADDYVAKPVQPRVLLARIRALLRRTDKTVEDEVAQRIEFDDLVIDNGGRSVTLNGELVDFTSAEYDLLWLLASNAGRILSREDIFERLRGIEYDGQDRSIDVRISRIRPKIGDDPENPKRIKTVRSKGYLFVKETNGL Kraken2_NZ_CP077849.1 IMICODJL_40829 Prodigal:2.6 1940010 1941659 + VFG038231(gb|WP_000472465) 100.0 0.0 (bfmS) signal transduction histidine kinase VF0463 BfmRS VFC0301 Regulation Two-component system: BfmS sensor kinase acts as a BfmR phosphatase to negatively regulate BfmR activity in certain conditions Controls biofilm formation and cellular morphology; participates in cell adhesion, resistance to serum killing and antibiotic susceptibility Activates the expression of the usher-chaperone assembly system responsible for the production of pili needed for biofilm formation on polystyrene surfaces; inactivation of bfmS may affect the regulatory process and/or translational modification of OmpA leading to loss of OmpA-mediated pathogenesis MFKHSIFLRIYAGLVILVVLVAVFGYLLVQIINYQRAQEYRESLTDGISYVISEGVARQPGKQQKIDWISDASDLLELPIYYTDASKVELSRTEKKRIEAQKSVVRYDASNSIAYVIIGLRDDPQHYLSIKVDKITERQMKALPIFVLDYLMFYPGQEQEYLAKIQKHFSYPINIQNIQDVNLDSEQIGRLRQDQSVMLYKDSATVRGTTISIVSPIPNHPAQVLVLGPVPMFNWMPLQLSAGITLFSLFLLSLGVYGLILPLERKIRQVRYALNRMKSGDLSLRVPIEGSDEMANLASSYNNMSDHIQRLIEAQRELMRAVSHELRTPVARIRFGTEMLAEEDDYNHRMHQVDMIDKDIEALNTLIDEIMTYAKLEQGTPSLDFAEIVLFEVLDQVAVETEALKTQKEIELIPPPLYVKVDAERRYLHRVVQNLVGNAVRYCDNKVRITGGIHNDGMAFVCVEDDGPGIPEQDRKRVFEAFARLDDSRTRASGGYGLGLSIVSRIAYWFGGEIKVDESPSLGGARFIMTWPAHRFKQPPLKTNKKAPA Kraken2_NZ_CP077849.1 IMICODJL_40946 Prodigal:2.6 2060816 2062006 + VFG046459(gb|WP_004287053) 79.2 9.9e-234 (tufA) elongation factor Tu VF0460 EF-Tu VFC0001 Adherence Surface-expressed elongation factor-Tu (EF-Tu) mediates attachment by interacting with host cell nucleolin MAKAKFERNKPHVNVGTIGHVDHGKTTLTAAIATICAKTYGGEAKDYSQIDSAPEEKARGITINTSHVEYDSPTRHYAHVDCPGHADYVKNMITGAAQMDGAILVCAATDGPMPQTREHILLSRQVGVPYIIVFLNKCDLVDDEELLELVEMEVRELLSTYDFPGDDTPVIRGSALAALNGEAGPYGEESVLALVAALDSYIPEPERAIDKAFLMPIEDVFSISGRGTVVTGRVEAGIIKVGEEVEIVGIKDTVKTTVTGVEMFRKLLDEGRAGENCGILLRGTKREEVQRGQVLAKPGTIKPHTKFDAEVYVLSKEEGGRHTPFLNGYRPQFYFRTTDVTGAIQLKEGVEMVMPGDNVEMSVELIHPIAMDPGLRFAIREGGRTVGAGVVAKVTA Kraken2_NZ_CP077849.1 IMICODJL_40975 Prodigal:2.6 2088153 2089271 - VFG050400(gb|WP_000347039.1) 100.0 5.9e-267 (pilU) PilT/PilU family type 4a pilus ATPase VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MDFNDLLNLMVEKKSSDLFITDGVAPSMKINGQIVPISKNSLSGEVIGQLLHSIMSEKQRREFAETRECNFAIMNREKTARFRVSAFQQRDMPGMVLRRIETKIPSIDDLQLPPVLKDLSMTKRGIIIFVGATGTGKSTSLASMISHRNHNSKGHIITIEDPIEFIHEHAGCIITQREVGIDTDSFEIALKNTLRQAPDVILIGEIRSREVMDYAIGFAETGHLVLATMHANNANQALDRIIHFFESDRHSQLYMDLSLNLKAMIAQQLIPTPDGNSRRAAIEILINSPLISDYIRKGEIHEIKDLMKRSRELGMQTFDQALFDLYKAGQITYKDALKHADSPNDLRLTIKLADEGPDQLSDGKQHLTFDRQ Kraken2_NZ_CP077849.1 IMICODJL_40976 Prodigal:2.6 2089299 2090366 - VFG050395(gb|YP_005797773.1) 100.0 6.019999999999999e-256 (pilT) type IV pilus twitching motility protein PilT VF1334 TFP Type IV pili VFC0001 Adherence Essential for twitching motility and natural competence, and contribute to host cell adherence MTYFDLLGEIMDITELLAFSVKNGASDLHLSAGMPPMIRVDGEVRRINLPALEHKDVHRLVYDIMNDKQRRDYEEKLETDFSFEVPNVARFRVNAFNQNRGAGAVFRTIPSKVLTMEDLGLGQIFKDICDYPRGIVLVTGPTGSGKSTTLAAMLDYINENRYDHILTVEDPIEFVHQSKKCLINQREVHRDTHGFNEALRSALREDPDIILVGEMRDLETIRLALTAAETGHLVFGTLHTTSAAKTIDRVIDVFPAEEKDMVRAMLSESLQAVISQTLLKKNGGGRVAAHEIMIGIPAIRNLIRENKVAQMYSAIQTGANHGMTTLDQSLKGLVARGVISPQTARTAAKQPESFL Kraken2_NZ_CP077849.1 IMICODJL_40985 Prodigal:2.6 2100273 2101370 - VFG013197(gb|WP_011608705) 64.3 4.08e-146 (hemB) porphobilinogen synthase VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MGLQYSSRLTVMEYPPTYPSVIPNIEIVMTYTFNRPAFPATRMRRIRKNDQLRAMVSETQLTTNHLIYPVFVLPGQNQTQDIPSMPNIQRLSADLLLKKAERLLELGVSKLALFPVTPQEDKSLTAEAAWREDGLVQTTCRLLKKELPEMVLITDGALDPYTTHGQDGIIDETGYVLNDETVECLIKQALSHAEAGAEVIAPSDMMDGRIGAIRQALEANGHIYTNIMAYSAKYASSFYGPFRDAVGSASNLKGGNKYNYQMDFANRAEALHEIALDIQEGADMVIVKPGMPYLDVVREVKDTFGIPTFIYQVSGEYAMLAGAIQNGWLSDSVILESLMCCRRAGADGIWTYFAETAAEKLKEMN Kraken2_NZ_CP077849.1 IMICODJL_41105 Prodigal:2.6 2207987 2208877 + VFG037467(gb|WP_001105559) 100.0 3.0700000000000003e-217 (ABK1_RS04735) LysR family transcriptional regulator VF0636 HemO cluster VFC0272 Nutritional/Metabolic factor Current studies show the hemO gene cluster is required for optimal utilization of heme in A. baumannii hypervirulent strains; The hemO gene cluster encodes a secreted hemophore. MNYELWKIFLDAVELGSLSKVAMLHNTNQPQISRQMNELEAQCGGRLFNRTGRGVELTDLGQHLLPKIRSWLNVTDQLNNEILHSTDTPIGTVRIASLPSTAHPLLSTLYKVLQQKYPLIKLSVREGQGVHLEKWLEDGSVDLAILYRFNPTPKQGDIYLIQADTYLVGSEGDALTQASEVDFKEISQLPLVTFCRPSNWRNFLDHMAYENGVELNIVFEADSISLQTHLVSESRMYTMLGPQALKKASQYTSIQAAKIINPALKRYISLSISKHGYLTPACKAVMEEIRNLADLL Kraken2_NZ_CP077849.1 IMICODJL_41106 Prodigal:2.6 2208892 2209167 - VFG037544(gb|WP_000061141) 100.0 1.4e-63 (ABK1_RS04740) hypothetical protein VF0636 HemO cluster VFC0272 Nutritional/Metabolic factor Current studies show the hemO gene cluster is required for optimal utilization of heme in A. baumannii hypervirulent strains; The hemO gene cluster encodes a secreted hemophore. MSLYNFSVFLGGLLFVSIASAGYKSNAHRDFYSKCVAAGHSRATCLCIYHRLERQYSPKLMHKLGKLSLQSPEVPRDFVKTMLRTMQQCQS Kraken2_NZ_CP077849.1 IMICODJL_41197 Prodigal:2.6 2313447 2313749 + VFG000269(gb|WP_000779223) 61.0 5.17e-33 (ureA) urease alpha subunit UreA VF0050 Urease VFC0282 Stress survival ~550kDa nickel metalloenzyme comprised of two distinct subunits-UreA and UreB, the UreEFGH proteins are required for activation of urease by incorporating nickel ions into the urease apoenzyme, UreI functions as an acid-dependent urea channel; PDB code: 1E9Z An important colonization factor, contributes to acid resistance, epithelial cell damage, chemotactic behavior, and nitrogen metabolism A Ni2+-containing enzyme, catalyzes the hydrolysis of urea to ammonium and carbon dioxide. Urea channels (UreI) present in the inner membrane are opened at pH<6.5, allowing delivery of urea to urease. The ammonia produced diffuses into, and thus buffers the periplasm. MELNPTEKDKLLIFTAGLVAERRKARGLKLNYPEAVAFISAALLEGARDGMTVSELMHFGTTLLKREDVMDGVPEMIAEVQVEATFPDGSKLVTVHQPIV Kraken2_NZ_CP077849.1 IMICODJL_41199 Prodigal:2.6 2314106 2315806 + VFG006476(gb|WP_011115250) 62.5 1.97e-259 (ureB) urease beta subunit UreB, urea amidohydrolase VF0050 Urease VFC0282 Stress survival ~550kDa nickel metalloenzyme comprised of two distinct subunits-UreA and UreB, the UreEFGH proteins are required for activation of urease by incorporating nickel ions into the urease apoenzyme, UreI functions as an acid-dependent urea channel; PDB code: 1E9Z An important colonization factor, contributes to acid resistance, epithelial cell damage, chemotactic behavior, and nitrogen metabolism A Ni2+-containing enzyme, catalyzes the hydrolysis of urea to ammonium and carbon dioxide. Urea channels (UreI) present in the inner membrane are opened at pH<6.5, allowing delivery of urea to urease. The ammonia produced diffuses into, and thus buffers the periplasm. MKMSRRAYAEMFGPTVGDRIRLADTALFIEVEQDLTTYGEEVKFGGGKVIRDGMGQSQLLADEVADTVITNALIVDWWGIVKADVGLKNGRIWKIGKAGNPDIQPDITIPLGAATEVIAGEGQILTAGGIDTHIHWICPQQVETALMSGTTTMVGGGTGPAAGTSATTVTPGPWHIATMLQAIDDLPMNIGLLGKGNLSLPDPISEQIKAGVIGLKLHEDWGSTPAAIDNCLSVADEYDVQVAIHTDTLNEGGFLEETLAAFKDRTIHTYHTEGAGGGHAPDILKAIGQSNVLPSSTNPTRPYTINTIDEHLDMLMVCHHLDPAIAEDIAFAESRIRRETIAAEDILQDLGAIAMMSSDSQAMGRVGEVILRTWQTAHKMKVQRGPLEGDNEFHDNNRVKRYIAKYTINPAITHGLSHEIGSVEVGKLADLVLWKPAFFGVKPSMIIKGGMIAAAPMGDINASIPTPQPVHYRPMFGAYPRGVHNTCITFLSQVAIDKKVAEKLNLKKLISPCKNTRSITKADMKHNTYCPVMQVHPETYEVRADGELLTCEPADVLPMAQRYFLF Kraken2_NZ_CP077849.1 IMICODJL_41202 Prodigal:2.6 2317035 2317649 + VFG006495(gb|WP_011578340) 61.9 1.31e-91 (ureG) urease accessory protein (ureG) VF0050 Urease VFC0282 Stress survival ~550kDa nickel metalloenzyme comprised of two distinct subunits-UreA and UreB, the UreEFGH proteins are required for activation of urease by incorporating nickel ions into the urease apoenzyme, UreI functions as an acid-dependent urea channel; PDB code: 1E9Z An important colonization factor, contributes to acid resistance, epithelial cell damage, chemotactic behavior, and nitrogen metabolism A Ni2+-containing enzyme, catalyzes the hydrolysis of urea to ammonium and carbon dioxide. Urea channels (UreI) present in the inner membrane are opened at pH<6.5, allowing delivery of urea to urease. The ammonia produced diffuses into, and thus buffers the periplasm. MTERSPLRVGIGGPVGSGKTALTLNLCRALRDKYNMAVVTNDIYTKEDSNFLTRNEAMSPDRIVGVETGGCPHTAIREDASINLAAIDDLCEKFDGLELIIIESGGDNLAATFSPELSDLTLYVIDVAGGEKIPRKGGPGITKSDLLIINKTDLAPMVGANLDVMDQDAKRMRGEKPFLFSNMKTQDGLEEIIQFIEKQGLFKA Kraken2_NZ_CP077849.1 IMICODJL_41216 Prodigal:2.6 2333319 2340116 + VFG050302(gb|WP_001045627.1) 99.3 0.0 (ata) trimeric autotransporter adhesin Ata VF1333 Ata Acinetobacter trimeric autotransporter VFC0001 Adherence Important for adhesion to host extracellular matrices (collagen and laminin) and basal membrane components MNKVYKVIWNASIGAWVATSEIAKSKTKTKSKTLNVSAAVLSGVICFAPNAFAGTNTEGGIGQGTSISGTTSCREGSANTANQKDIAIGCGAQTQDRTGSNIANRNNPYNNSTGAYAGAMKQGGAISVGTGAVVEKGLGTAIGSYATTQGISGVAIGTGALSSGNTALAVGRQSAATADFSQAIGNVAAATGKGSLAIGHSATAEGYRSIAIGSPDIENADPVAGQVGAAYQPKMATKATGKDSIAFGGGAVATEENALAIGAFSESKGKKSVAIGTGAKAQKDNAVVIGDQAEASFEGGVAIGKGARSEAENSIALGKDSKASQATGESYLTKQSAPTGVLSIGDIGTERRIQNVADGAADSDAATVRQLKAARTHYVSINDNGQQGGNFENDGATGRNAIAVGVNASAAGREAMAIGGSAQAIGSGAIAMGSSSQTVGRGDVAIGRNASTQGAEGVNSNQSVAIGDQTKAIGDQSVAIGADVIAKGNSSVAIGGDDVDKIARDTELSNTYTEITGGTLQAGKYPTTEANHGSTAVGVQAVGTGAFSSAFGMTSKATGDASSAFGVMSNASGKGAAAFGAVAQATGDGASAMGINSLASGTNSTAIGSGNKPGEGAKATGNSSAAIGSGAQATGDNSAAIGKGAEATNENAAAVGGGAKATGKNAAAIGGGAIADQENAVAVGQGAQSLVEGGVALGARSKVEAKNSVALGQDAVATEATGTSFLTNRDASQSNGVISVGSAGKERRITNVEDGSADSDAVTVRQLKNVDSRVNQNTSNIGKNTQNITNLNQKLDDTKTNLGNQITDTNKNLNDAKKDLGIQITDTNTKLNTTKDQLTTQINDTKTELNNTIGNTKTELNTKIDNTKTELENKGLNFAGNSGADVHRKLGDKLNIVGGAAASTPAAKTSGENIITRTTQDGIQIELLKDSKFDSVTTGNTTLNTNGLTIKEGPSITKQGINAGSKQITNVADGINAKDAVNVDQLTKVKENLNGRITDTNNQLNDAKKDLGNQIADTNKNLNDAKKDLGDQITDTNTKLNNTKDQLTTQINDTKTELNNTIGNTKTELENKGLNFAGNSGSDVHRKLGDKLNIVGGAAASTPTAKTSGENVITRTTKDGIQIELLKDSKFDSVTTGNTTLNTNGLTIKEGPSITKDGINAGGKKITNVADGINAKDAVNKSQLDNLAAKQNATDDAAVKYDDAKTKDKVTLKGKDGTVLDNVKAGHISSTSKEAVNGSQIHNISNSIKNSIGGNTVVNPDGSLTTSNIGGTGKNNINDAISEVKNTAKKAKTTVTEGDNIVVKETVNKDGSTNYEVSTKKDLTLNSVTTGDSVLNNNGLTIKEGPSITKEGINAGGKKITNVADGINAKDAVNVDQLTKVKDNLNGRITDTNNQLNDAKKDLGNQIADTNKNLNDAKKDLGDQIADTNTKLNNTKDQLTTQINDTKTELNNTIGNTKTELNTKIDSTKTELENKGLNFAGNSGADVHRKLGEKLNIVGGAAASTPVAKTSGENVITRTTKDGIQIELLKDSKFDSVTTGNTTLNTNGLTIKEGPSITKDGINAGGKKITNVADGINAKDAVNKSQLDNLAAKQNATDDAAVKYDDAKTKDKVTLKGKDGTVLDNVKAGHISSTSKEAVNGSQIHNISNSIKNSIGGNTVVNPDGSLTTSNIGGTGKNNINDAISEVKNTAKKAKTTVTEGDNIVVKETVNKDGSTNYEVSTKKDLTLNSVTTGDSVLNNNGLTIKDGPSITKDGINAGGKKITDVANGVIAQNSKDAVNGGQVHHISNSIKNSIGGNTVVNPDGSLTTNNIGGTGKNNINDAIKSVDEKVTNGVNDLTQKGLNFGANDQKTTQGKAVHRKLGDTINIVGGANPETAEDKTSGENIITRTTEDGVKIEMLKDVKFDSVNVGGHVLNQQGLTIKGGPSITVNGINAGGKQITNVADGINAKDAVNKGQLDKQINEVKDQIGKDIGKLSDHAVQYDKDKNGNVDKNSVTLGGGEKGTNLKNVADGKIAEGSKDAVNGGQLWNVQNQVDKNSNDIKNIQNNIDNISNGKAGLVQQQKPNGEITVGKDSGGTSINMAGKEGDRVVQGVKDGEIKAGSNQAVNGGQIHKISESIKNSIGGNTTIDPKDGSITTNNIGGTGKNNINDAIGTLNQSNQELGNKITNLGDQLQQVFYDTNKRIDDVEKKANAGIAAAMALENAPFVAGKYTYAVGAAYHGGENAVGVTLRKTSDNGRWSITGGVAAASQGEPSVRVGISGVIN Kraken2_NZ_CP077849.1 IMICODJL_41337 Prodigal:2.6 2437852 2441046 + VFG050931(gb|WP_000482875.1) 100.0 0.0 (vgrG/tssI) type VI secretion system tip protein VgrG VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MFNNIFQILESFGFLSQHRSVYLQFSDASLNSQVFLQRIDGQHYLNQGMTAELICLSTNAHIPLKTFIGVQVAVDQVTDRGSFFRTTGIITGASQGQSDGALTLYKLAISDPTYLWHKRRNSRVFMNKSVKEISEILFQEWQGKSPLFASSLTLDLSGLKQTYDVRPFVMQLNESDYDFLTRLWRSEGISWLIDEAELTVASNMDNIQPQKLRLIDDNNQYQALTRRAIRYHRSSATEQFDSMTSLMADRSLQPTSIFVQRWQPDVLQQTDGAGSVQSKHQHSTNYDNQSLSLEEAWHFSPAWMQDLNGEDGATSASNQQLEKFNQNLSAYYDAQSKQFIAKTTVRDTQVGYWFELNEHPEIDQHESTDKEFLIIGKNYYNQNNLPKDLNQQIQTLVQQSDWQASNTDERQANQLILQRRYIPTTPAYNPQTHSPVAHPQRAKVVGPEGEEIYVDEWGRIKVRFLFTRSDDHSHDGGAGTNNNDTDSAWIDVLTPWAGEGYGARFLPRIGEIVVINFFNGDIDRPFVMGRVHEAQRHPTKFDNKGKLPDTKKLSGIRSKEVSGGGFGQLRFDDTPGQISTQLQSSHGASQLNLGKLSHPKDKAESEDRGEGFELRTDQWGALRAGQGLLVSTHKQDNAKGDHLDAEVAKKQLEGSQTNSKALSDIAKNQKTDEIESIEQLKDFASQIQQQIAKFEKALLLLSSPDGIALSSSEDIHISADAQINQIAGDSINISTQKNVIAHAQNRLSLFAAQSGLKAVAAQGKVEIQAQADALDVLSKLGITISSTDDKVIISSPKEVKITGGSSQITLNGSGIFPKTGGKFQVNAGQHLFMGGASANASAPELPKAKPMQGALELLRSYGGDNFFKQNSYKVIDSLGKQITGKLDGNGFAQVTGIAPGPAKVVFEKDNTSAWLQSSDFKRNYTWAEPVKSVQGLMKNALEAVGQNTMSQLQNNLLSTDKNSFKNLGKNTLDNLAGQTVAQIKNQVTNTALNTVSKQLNLNLSADQMKSLGQMATNPSQSLEMLKEQGGDFLSDQMTAKLFKTTNQESPIQQGDLDTFVRSKK Kraken2_NZ_CP077849.1 IMICODJL_41363 Prodigal:2.6 2467531 2467785 - VFG045727(gb|WP_003636647) 76.3 3.83e-25 (csrA) carbon storage regulator CsrA VF0261 CsrA VFC0301 Regulation Belongs to a highly conserved family of global regulators that typically control stationary phase traits post-transcriptionally Post-transcriptional repression of the transmission regulon Binds to particular mRNAs at a consensus sequence encompassing the ribosome binding site (RBS), destabilizing the mRNAs and preventing their translation MLILTRRVGETLMIGDQVSVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQHERAMHEHLQHLDQDYQVSYEDDNYAQKNFNR Kraken2_NZ_CP077849.1 IMICODJL_41378 Prodigal:2.6 2483120 2485699 + VFG049189(gb|WP_014226431) 65.1 0.0 (clpV) ATP-dependent chaperone ClpB VF0783 T6SS-II VFC0086 Effector delivery system MRFEKFTNRLQQALSDAQSLAMGKDHTAIAGIHILSTLLEEPSNISLLQQAGARLPELKQKLEQALKDAPTIANPTGDVNLNPEAVKALNLADRYAQKAGDEFLSTDWVLLGLAETGETKNILSAVGVTPDSLRKVIENIRGSDKVMSNNHEDQRDSLNKYTIDLTERALSGKLDPVIGRDDEIRRTIQVLSRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKNKRVLSLDLGSLLAGAKYRGEFEERLKAVLKDLAKHEGEIILFIDELHTLVGAGKGDGAMDAGNMLKPALARGELRCVGATTLDEYRQYIEKDAALERRFQKVLVDEPSVEDTIAILRGLKEKYATHHGVQILDSAIIAAAKMSHRYITDRQLPDKAIDLIDEAASRIKMEIDSKPEALDKLDRRLIQLKMQLEAVKKDEDAGSKAEVTHLEKQIAEVEKEYNDLEEVWKAEKTLVEGTKQAQVELDKARIAFEKAQREGDLAEAARLQYGVIPELQKQLEQDEVAEENEEPKLIRTKVTENEIAEVVSAATGIPVAKMMQGEREKLLHMEEFLHDRVVGQDEAVVAVSNAVRRSRAGLSDPNRPSGSFLFLGPTGVGKTELTKALANFLFDSDDAMIRIDMSEFMEKHSVSRLVGAPPGYVGYEEGGVLTEAVRRKPYSVVLFDEVEKAHPDVFNILLQVLDDGRLTDSQGRVVDFKNTVIVMTSNLGSQDVRELGEGATDDEVRTIVMNAVSQHFRPEFINRIDELVIFHSLKKAQIRGIADIQLDRLRSRLVDRDMSLTVDDSAFDLLIDAGFDPVYGARPLKRAIQQQVENTLAQKILSGDFVAGDTILVKGENGHLVFDKLKLS Kraken2_NZ_CP077849.1 IMICODJL_41459 Prodigal:2.6 2563229 2564161 + VFG037762(gb|WP_000078878) 66.2 1.17e-150 (lpxL) lauroyl acyltransferase VF0466 LPS VFC0258 Immune modulation LpxM dependent acylation of lipid A is essential for A. baumannii desiccation survival, a key resistance mechanism for survival in hospital environments Evasion of the host immune response, triggering the host inflammatory response MTKPEAQYQSGQFQFSFLSLKYWGIWFTAFILMFLAYLPWAIQWRLAKLFSKIAWTLLGSRRKTTLRNLGACFPEKTPEQIEAKAKSVFTDTMIGIFEALNAWYCPAWFKKRVHIEGLEHLNDNRDRGILLLGTHSTLLDAGGAACTLFFDMDVVYRPQNNPFMDFLIHRSRARVYKNQIAKDNMRSLIEKLKNGHAIWYSPDQDFGLKQGVMASFFGIQAATVTAHRRLMDISNAVAIPLYFYRSGDIRDPQYNVLVEPKLENFPSECEVNDAERVNKIIENQIRIAPTQYMWFHRRFKTRPAGEAKFY Kraken2_NZ_CP077849.1 IMICODJL_41472 Prodigal:2.6 2576581 2579757 + VFG050911(gb|WP_000934999.1) 100.0 0.0 (vgrG/tssI) type VI secretion system tip protein VgrG VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MLNSIHQVLDSLGISPQKRAIHVQFTSPILNDQVFLQRIDGVHALNDGLKAELLCLSTNATIQLKSFIGVQAAVDIVTERGELTRVTGIITHAQQGQSDGSLTLYKLTLEDPTALWKYRRNSRVFMNKSVVEIWEILFKEWQTKNPLFAASLSLDLSGLTQTYDVRPFVMQHNESDWNFLTRLLRSENISWLIDEAQHIVPSTDTSIQAQKLRLIDANSQYQPLDRKTIRYHRSSAVEQYDSMTRLTAERSLQPNVMHIQRWQAEILDQEEGIGSVQSKHQHSEHYDNATLGLEQAWNYSPAWIGDLKGEDGVTKSGNQQVERLNQNLHNYYEAQAKRFIAQTTVRDAYVGYYFELNEHPEIDQHESSDKSFLIVSKNFFNQNNLPKDLNDQINGLLAQSNWAIQNPENSDERQANQLILQRRHIPTTPAYNPQIHSPVTHPQRAKVVGPEGEEIYVDEWGRIKVRFLFTRSDDHSHDGGAGTNNNDTDSAWIDVLTPWAGEGYGARFLPRIGEIVVIDFFNGDIDRPFVMGRIHEAQRQPTKFDNKGKLPDTKKLSGIRSKEVSGGGFGQLRFDDTPGQISTQLQSSHGASQLNLGKLSHPKDKAESEDRGEGFELRTDQWGALRAGQGLLVSTHKQDNAKGDHLDAEVAKKQLEGSQTNSKALSDIAKNQKTDEIESIEQLKDFASQIQQQIAKFEKALLLLSSPDGIALSSSEDIHISADAQINQIAGDSINISTQKNVIAHAQNRLSLFAAQSGLKAVAAQGKVEIQAQSDALDVLANKGITISSTEDCIEISSPKEIVITGASSQITLNGSGIFPKTGGKFQVNAGQHVFQGGASASVQSSLPPPPKRVQGVLELFHEYAHGEFVKGGSYRVVDNFGKEVTGKLDDKGFAKVSGLATGAVKVFFESDHRDPWDTASDFKRPVEWPNKNDADSEQSDSLIAQMSKTAQSKLGELSKQLTNPTNIMKNIQTAQSIKSEGAKALMPMLKTQAQGLVTDQVKSFLPISEAGQKIGNNIELTSIQKMNDFNKSGSIDGNSLVNNTLHQYLQSPFKKNS Kraken2_NZ_CP077849.1 IMICODJL_41504 Prodigal:2.6 2615112 2615615 + VFG051056(gb|WP_001119042.1) 100.0 7.16e-109 (tssB) type VI secretion system contractile sheath small subunit VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MAKRESVQKKLQRIRPPRVQLTYDVEIGDAKEAKELPFVVGVMGDFSAASELERTKLKDKKFINVDLDNIDEVMESLSPRAAFQVDNTLTEEGGKMAVDLTFKSMEDFRPENVVQQVDPLKKLVEARERLTDLRNKISNSERLEDLLDEVLKNTDQIRKLSAEADHE Kraken2_NZ_CP077849.1 IMICODJL_41505 Prodigal:2.6 2615608 2617089 + VFG051070(gb|WP_001066523.1) 100.0 0.0 (tssC) type VI secretion system contractile sheath large subunit VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MNNTQSAAMPLVENEEVNLLDSIVEQSRIARNEEEHSRAKSLIGELAKEVMAGTITVSENMTLSIDKRIAEIDALISKQLSQIMHNEQFQKIESTWRGLYYFCQETPSNPLIKIRMLNTTKKELVKDFQGATDFDQSTLFKKIYEEEYGSFGGAPYSALIGDFEFDRTPSDMYLLEQISHVAAAAHAPFISAASPSILGLESFTDIDRPRDVSKIFETAEYVQWRSFRDSEDSRYVALTLPHVLGRLPYHPKEGTATEGFNFIEDVSGENHNEYLWMNAAYAFGTRLTNAFDMHGWCAAIRGVEGGGLVEGLPVHTFKTQDGEVVFKCPTEIAITDRREKELSDLGFIPLVHCKNTDYAAFFGAQSTQKPKKYDNDTANANSALSSQIQYIMAVSRIAHYLKAMMRDKVGSFASAGNVEAFLNEWLSQYVLLDDGASQEAKAQYPLREASVKVVEDPAQPGHYKSVVFLRPHFQLDELSVSLRLVTELPQSSN Kraken2_NZ_CP077849.1 IMICODJL_41506 Prodigal:2.6 2617139 2617642 + VFG051042(gb|WP_000653195.1) 100.0 2.72e-122 (hcp/tssD) type VI secretion system tube protein Hcp VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MKDIYVEFRGKYKVDGESRDSEHKGWLEVNSWSHNIRQPKSATSSSVGGHTAERVEHSDMVFVKDLDATSPKLWEACSAGYTFDEVQIDFYRANGDKRIKYLQIKLKHVLVSSVTPTVNEEGVPTEAFGLKYAAVEWTYNQQDINGTAKGAVTKKWSLSNNTASYAA Kraken2_NZ_CP077849.1 IMICODJL_41507 Prodigal:2.6 2617722 2618198 + VFG050986(gb|WP_001047031.1) 100.0 3.23e-112 (tssE) type VI secretion system baseplate subunit TssE VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MNLDRLYPYGFRSTLFDRLIPESEDYAKGLSIQQLRESVAKDLEDLLNSRVAKLDHVIDDYPLVKKSILQFGIIDFVGLSTANPLDRDKICQSIEQSIAAHEPRLRQIRVEMLLDGHNMGALCLSIQAYLNIHPLYEPVVFDALLKPTTQQYVISART Kraken2_NZ_CP077849.1 IMICODJL_41508 Prodigal:2.6 2618215 2620026 + VFG051000(gb|WP_000568832.1) 100.0 0.0 (tssF) type VI secretion system baseplate subunit TssF VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MIEELLPFYEKQLQEFGQQSREFAQKYPKIAQRLSLNQEQIDDPHIERLIQAFSLIAARIDKKLTDSYDVFTRSLFEVMFPQYLRHFPACSVVSFEDINKIKQLTEPHLVPHHTVLKSRSFKGVQCEFNTTQEVKLLPIHLSGLDFKTTPSAHMHLNQNATLSLKFEIFNNAHACLTDEKLPIYLDAISNFPLQVLDSIFKKGTSFAVKYGQTIVELSKNPFELIGFAEQESLLPLDQHTHHAYRLLMEYFCFPEKFSYLKLDLDFLRRLPQHVSEFELLIHFKLNLNDQAVVRNYSELNIANFKLFTTPVINLFEKYAEPQKIVHKQLEYPLVTDAHHPEFYQVYSILEMNMVREKTNQEESYVPVLPFFAMSHYHNDTARFFYSVNYQKLQSNFVEMGYSIISKNLNPFSTRSDFISTKLLCSNRDLPHEALGQSNNVLNLNDSSLARRAIVLKRPTKPYKFEQGQSEQWRVISHLSLNSLALMKGDAVSHVKELLALYNLPQSKENYLIIESIKKLEFSLTHKLVDGKPFPMFVRGVKAELQIDSSVFRGHSLYIFSQLLSRVFNLKVQINSFVDLVVKDYSSQQELYQCSQNVGGKTLL Kraken2_NZ_CP077849.1 IMICODJL_41509 Prodigal:2.6 2619990 2620988 + VFG051014(gb|WP_001190395.1) 100.0 3.85e-245 (tssG) type VI secretion system baseplate subunit TssG VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MQSERWWQDSSVTAELFQRPKSFEFIQATRLLRHMPANDAALSWSDHFKFETSFNLNFPATEIESLELVDERVHLTNLIVGLTGIQGALPYTYTNKIKQAPRQQRAETKEFLSLFNHKLTSQYVESSITYHLPVRYEIENKNDYLDILHALNGYVRSQHQQQDLDEYFAEFSGLMQGQNNTVHALKTMLSCIFKHEITIKEFVQESFKLAGDQLTTLGGSQPSLLGINTFCGETIQQIDGKIEIQIGPLKRQQYLKFLPHQELSLKLKKIVETWCSPTLSIDLRLILDETEIQPVRLTQGQESGLGQGAFLMSRKPNTHNDETCYSLIGEQI Kraken2_NZ_CP077849.1 IMICODJL_41511 Prodigal:2.6 2622428 2626252 + VFG050962(gb|WP_000556914.1) 99.9 0.0 (tssM) type VI secretion system membrane subunit TssM VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MHTILGYLWQYITNPKAIIALSLFVALMSSYTSIPRHIFWALASAYALGLIAYGIYWLIQRKKHAVQGEELAQAIEKDTQAEYGKNKDKEELQLISQQMKESIQLIRKSKLGDKKGNAALYELPWYMVIGNPAAGKSSAIYNSGLKFPFEETHQKMVSAGLSGTRNCDWFFPTEGILLDTAGRYSVYSEDHSEWLGFLNILKKNRSKAPVNGLILIVSIAELVSQSPEHSLKLAKNLRARIQDLTERLEVVVPVYLVFSKMDLIAGFTEFFEFYEAQEYNQAWGATLPYEQNSSHNAVDLFEKHYNILYDGLKGVSSTHLSRRHSQNISPSVMTFPLEFKTLKPALKSFIATLFEDNPYQFQPVFRGFYFTSALQEGVIESPMTEQIAQEFQLSQIAQSEVKDQLKTTPNHGYFLKGLFSDVILKDKDLVKQHVNTSKKRQRYIAFIGALAGVSIILGVWVWSYRNNQQLIAEVQADLNKVVQLEKSSGQQLSTQLEALLILQRRLQQLDEFDENRPLKFSFGLYQGNELREKLKAEYLKGVKQIVLIPTQQNIAQYLQRVKNNEATLKANHTNVEIKQTAQTQQYLEPSDTNPQDAYNALKAYLMMSNPQYMDASHLSDQVTRFWRSWLDANKGQMPRADMIQEAEQILSYAMTLANDKQFPILDADSQLVDQTRQVLLSVIRGMPARDRVYNEIKMRAAVRFPALTVNQIVGDANKNIVLGSYALPGVFTQKAWNEYVEKAIEEAADKPTDTKDWVLNSRQSDDLTFSGSPEQIRKQLTALYKQEYIAEWRKFLSGIHYAKATQFAQQVKNIDVLGEPQNSPIRMLIERVAIETNWDNPVVQAELAAPQKGFIAWFKRKVLNHDDKQLANQAVTNAQGPISQEYQMFYQLVRKRDDQQGKSLLDEYMTNLALVRSKFNELKNAGEIGPNAMTLVKQTLNEQTSVFNQTQKIVDEKMAVGFSEIDQQLLQKLVVSPLTQAFESLITPTQDEINKLWVMQAYQPFTANLAKKYPFNSSASLQATSSEIGQILGENGSISRFVKESLDPFVIRRGYTLTSKTWKDLGISLNPQFVMNFQRYVAPTNGMATGELNSQAPAAPATNQSNFQFYPIQNPQLLSYTVDIDGQRMTYENGVQQWVNFIWPNQGSIPGARITAVDLQGQTHTIFDEPGEYGINRLIDSAQRKEQNGGFEMLWRSKTDPSLFVKMNFRLISSNSGSIGSSRGYSGMQLVDKVTADKAARVVSAQQAPAQAAAPAKTENPVSALAQPAAGVKP Kraken2_NZ_CP077849.1 IMICODJL_41515 Prodigal:2.6 2628522 2631200 + VFG051098(gb|WP_002001416.1) 100.0 0.0 (clpV/tssH) type VI secretion system ATPase TssH VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MSSLKILITKLSTAARTALEKSANACVLQQNYEIEIEHLFLELLNQPLENDLKILLKKYKISADALADDLKETISQLPKGNTRTPIFAKSIVRLFEQAWLLASAEQNPVIRSGHLLVALLTAPDLYQIATRASSLFDLFPIDSMKHKFLEICEKSVEQQEESKTSSQADELEQAVTPTAKTQKTPALDQYTINLTEKAKNGGIDPVIGREYEIRLMLDILMRRRQNNPILTGEPGVGKTAVVEGLALKIAQGLVPEALKNVHLHVLDMGLLQAGASVKGEFENRLKQVIQEVQSSAHPIILFIDEAHTLIGAGGQAGQNDAANLLKPALARGELRTIAATTWAEYKQYFEKDAALSRRFQVVKVEEPTEEVAVDMLRAMIPVMQKHFNLQIDDEAIVTAVHASHRYISGRQLPDKAVSVLDTAAARVALTQNAQPVKLDQLKAQEHNLKLEQQILENEHRQIPIHHERLENLKSQLESLQSEIQETQEQWQKELELVRKIQELEAQSHSNESEAYDQINLIRKDLADIQGQQPLVFERVNSQIINEIISDWTGIPVGKMVNDEIKQILTLEDKLGERVMGQDYALTQLVQGIKTSKAKLEDPNKPQGVFLLVGPSGVGKTETALALANELYGGEQHLITINMSEYQEAHTVSSLKGAPPGYVGYGQGGVLTEAVRRNPYSVVLLDEIEKAHSDVQELFYQVFDKGTLEDGEGRVIDFKNTTILLTSNTGSSAIMQACLNQPVEEWPTAEDLIEHLKPSLYKQFKPAFLGRMRVVPYFPLHDDLLVRIIKHKLGKITARIEKQYGTEVQYSDDLVELLLSRCTEVDSGARNVDNILNSTVLPALATEILVALADQKLPKLIMIDAKDDEIQYLLDPVAKPAKKRTSKKLKSEV Kraken2_NZ_CP077849.1 IMICODJL_41516 Prodigal:2.6 2631224 2632318 + VFG051084(gb|WP_000020713.1) 100.0 3.85e-268 (tssA) type VI secretion system protein TssA VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MSIDISELLKPINDSLLCGEDYSFSNEFHEIKKARTQDDLLLDQGDWVAERKQADWDFVAKSVSTLLIEKTKDIRLLTWVIEAWTHLNGFEGMVKGITLTHTMLNQYWQDIHPIIEDDDLDQRIGLLQGLINQLPMLLKKVPLTNTAPYYNLLDYDNFLYHENIRRKQTEEYESQSGPSELEQFDQAIFNTSKTFQYSNYQEFNSVLTEWNVLKQTLDHLMGLDSPSFAAIDSAFETIHSTLRKIYKAEAFGTGLAPSQEQAAVITTPSMENQVPVQIVSDQPMFQPQAQTHLANREQAMKVLQEIADYFQANEPHSPVSYMLQKTIKWSQMPLHEWLAQVIKDEHPLQMVQEMLGVQPKNEYE Kraken2_NZ_CP077849.1 IMICODJL_41517 Prodigal:2.6 2632335 2633699 + VFG051028(gb|WP_000471445.1) 100.0 0.0 (tssK) type VI secretion system baseplate subunit TssK VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MFKAEKVLWGEGLFLRPQHFQIQDTYHEQRLNHTVRAVVPFSYGVQKLSFDEAQLSTHILALESVEMIWQDGEIYQAPAYDLLPEPILLDELNLRGEMVIYLALPLLQANKQNLIDQNQSQKGRYQSHLVETHDLFTNATEADISLLRRRAVFKLLDAHSNPDHNLDGFLYLPIGKIKRQSSGAFEIDRKFIPPILHVDASETLVSNLKRTLNVIKAKIKTIQTNNRENEQKLIEFRSGDIVSFWLVNALNTAHAGLSHFLQYPQIHPERLFFELLRLAGSLLTFSTAYEVDQLPAYKHHNLQESFTQLDTILRDLLDTIISSRYISIALKEIRPSYWVGSLETDKITRDTRLYIAVSSSVMQTHELIQIVPLRFKIGSTLDVEQRVVAALPAIPLHHLIQVPTAIPVRSGVSYFEIELHHELYQRMLDSETICIYVPAGFQDISIELIAVMNA Kraken2_NZ_CP077849.1 IMICODJL_41518 Prodigal:2.6 2633717 2634523 + VFG050946(gb|WP_000083625.1) 100.0 1.43e-192 (tssL) type IVB secretion system protein TssL VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MSQSTGAPSLFDDGQIGTGGNNNSQSQVKLQAINLIDLLHDGFYLIFLIRNQYVPADPQRFREKILDLLNRFEQQAKKLQFSADDIHDAKYAFCALIDETIVTQQDPSYFNLQNSWLISPLQLSLFGSQLAGYQFFEILEQLRSRGKDRLAALEVFHYCLLLGFQGKYRIESIESLNHLVARVGDEIDYLKGKKVAFSPFSAIPDQIRNIIHRELPFFWILIFLLIFALLTFAGLRFMLNNQNDKALSNYQNVISAPQEQAHITIYLP Kraken2_NZ_CP077849.1 IMICODJL_41520 Prodigal:2.6 2635146 2636099 + VFG050972(gb|WP_000972583.1) 100.0 5.78e-228 (tagX) type VI-associated gene X, peptidoglycan hydrolase VF1337 T6SS VFC0086 Effector delivery system T6SS delivers protein effectors into host cells or competing bacteria and exists as an important virulence system in A. baumannii Four identified T6SS effectors: Tse1 is a predicted lipase, Tse2 is a predicted nuclease, Tse3 is an effector of unknown function, and Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activity MMIFLIFFCFACLAIGLAFLMSYELRNKGRTFVLSLLPQGRRQLNQVRQFAQTMNQAAAPEKLQSHWHLQQWWIVIAGFFLFASILIFAFTRPISSTRIEAEYLKKTDPQIYALLNGEILSPPPEVDESLIEAAIVEATQLEQQYASQESGVINSSPIDNTSFDGRAILDTSLVNRKWDKMNPRYKQRLLMVFKIMKEQYGYELVLLEGYRSPARQNMLAGNPNTTRAKGYQSYHQFGLAADVAFKRNGKVVISERDPWAMQGYRLYGQVAESVGLTWGGRWKSIQDYGHTEYRMPGLKKTQEMAEKLIAESLNDIS Kraken2_NZ_CP077849.1 IMICODJL_41744 Prodigal:2.6 2869204 2869953 - VFG039536(gb|NP_820549) 60.8 5.25e-94 (CBU_1566) Coxiella Dot/Icm type IVB secretion system translocated effector VF0696 T4SS secreted effectors VFC0086 Effector delivery system CBUA0020; CBU_0012*; CBU_0113; CBU_0122; CBU_0183; CBU_0201; CBU_0270; CBU_0295; CBU_0344*; CBU_0372; CBU_0375*; CBU_0469; CBU_0513; CBU_0534; CBU_0590; CBU_0635; CBU_0637; CBU_0820*; CBU_1048*; CBU_1079; CBU_1107*; CBU_1150*; CBU_1198; CBU_1268; CBU_1349; CBU_1370; CBU_1409; CBU_1434; CBU_1493; CBU_1495*; CBU_1525*; CBU_1530; CBU_1566; CBU_1576; CBU_1594; CBU_1607; CBU_1614; CBU_1639; CBU_1665; CBU_1677; CBU_1685; CBU_1752; CBU_1754; CBU_1789; CBU_1790; CBU_1794; CBU_1818; CBU_1819; CBU_1863; CBU_2016; CBU_2028; CBU_2056; CBU_2059*; CBU_2076; AnkA; AnkB; AnkF; AnkG (Interacts with host protein p32 to block apoptosis. ); AnkH; AnkI; AnkM/cig58; AnkP; Cem1; Cem12; Cem13; Cem3; Cem4; Cem6; Cem9; CetCb1; CetCb2; CetCb3; CetCB4; CetCb5; CetCb6; CirA/coxCC1 (Phosphate transporter family protein. ); CirB; CirC/coxDFB1; CoxCC10/cig49; CoxCC11; CoxCC12; CoxCC14; CoxCC15; CoxCC3; CoxCC4; CoxCC5; CoxCC6; CoxCC7/cig44; CoxCC8; CoxDFB3; CoxDFB4 (Surface antigen. ); CoxDFB5/cig57; CoxDFB6; CoxFIC1; CoxH2/rimL (Acetyltransferase. ); CoxH3; CoxH4/cig61; CoxK1 (Protein kinase, putative. ); CoxK2; CoxTPR1 (Conserved domain protein. ); CoxU1; CoxU2; CpeA; CpeB; CpeC/coxU3 (Hypothetical protein plasmid QpH1. ); CpeD; CpeE; CpeF; CpeG; CpeH; CvpA; MceA; PhnB; CBUD_RS05145; CBUD_RS06720*; CBUD_RS08635; CBUD_RS11275; CBUD_RS12405; CBUG_RS02435; CBUK_RS06760 MAGHSKWANIKHRKAKQDASRGKVFTKYIREIVTAAKLGGADPASNPRLRAVVEKALSVNMTRDTINRAIQRGVGGEDNDDLKEVTYEGYGVGGVAVLVETMTDNLNRTVPDVRHCFSKTNGNLGTAGSVAYLFTKRGEITFDDVSLEDKIMDVALEAGAEDIEVSEDEILVITSPETFGEVQDALAAAGLKSDNAEVVMSPSTKAEITDIDQAKQVMKLIDMLEDLDDVQNVYTNVEFSDEVLAQLDA Kraken2_NZ_CP077849.1 IMICODJL_41819 Prodigal:2.6 2941966 2942520 + VFG050817(gb|WP_000841373.1) 100.0 4.75e-129 (gspH) general secretion pathway protein H VF1335 T2SS VFC0086 Effector delivery system Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB Secretes multiple effectors that were shown to be required for virulence in vivo, including the lipoyl synthases LipA and LipH as well as the protease CpaA MKSNLPFQSQKGFTLIEVMVVIVIMTIMTSLVVLNIGGVDQKKAMQARELFLLDLQKINKESLDQSRVLALETHGETDVSPFSYELYEYHDQSTLQVQDIKNRWQKYTEFKTRQLPAHVSFSVQPLDDQNYSKAKNTDLIGGQTPQLIWFGNGEAKTVKIQFYLEQKPIGSEIQIDHLGKINEI Kraken2_NZ_CP077849.1 IMICODJL_41820 Prodigal:2.6 2942510 2942890 + VFG050832(gb|WP_000836911.1) 100.0 4.46e-81 (gspI) general secretion pathway protein I VF1335 T2SS VFC0086 Effector delivery system Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB Secretes multiple effectors that were shown to be required for virulence in vivo, including the lipoyl synthases LipA and LipH as well as the protease CpaA MKSKGFTLLEVMVALAIFAVAAVALTKVAMQYTQSTSNAILRTKAQFVAMNEVAMMEINQEWLQGTQSKQVTSQGETWQIDKSAQSTISPNVQKIDLQVSLYDPDKGKVQNGITHMVFFNYPVKAK Kraken2_NZ_CP077849.1 IMICODJL_41821 Prodigal:2.6 2942890 2943591 + VFG050844(gb|WP_000594589.1) 100.0 4.24e-163 (gspJ) general secretion pathway protein J VF1335 T2SS VFC0086 Effector delivery system Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB Secretes multiple effectors that were shown to be required for virulence in vivo, including the lipoyl synthases LipA and LipH as well as the protease CpaA MIKNKYIHIRSIDSRLAARSSSARLTRASGFTLVELLVAIAIFAVLSLLGWKIFDYLLKVRDRNAEHEVHLFELQDAYQQILRDTLQIIPLSANQGGQLHPALEIDNQILRFSKAGVTDPLKQGLSPFERIEYRYDADQKKLYRLKYTNLNTSNREQPLSSTLLSQVDQYQIMVLTPQEVTKWPEVNIDPTKPNELKKLPKGIKIQLTVAGVNYEWIYSLNQGDLSLSQEGNS Kraken2_NZ_CP077849.1 IMICODJL_41822 Prodigal:2.6 2943591 2944550 + VFG050857(gb|WP_000301476.1) 100.0 3.3499999999999994e-228 (gspK) general secretion pathway protein K VF1335 T2SS VFC0086 Effector delivery system Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB Secretes multiple effectors that were shown to be required for virulence in vivo, including the lipoyl synthases LipA and LipH as well as the protease CpaA MAVSYKHQQGVALLTILIMVALATILAASIAKHQNNTMENTAYLMRQNQSLLYAKSAEAFFSELLIQDANNAGGVDHLKETWAQPMPPFSIEEGSVSGRLLDESGKFNLNNLTNGEGIVNEDAKSWFERLLVRVGLPAELSQAVIDWQDPNDEPTGPMGAESSYYEGLDPGYMAANTKFHRIEELKLVRGFDGKKFDLIAPYISALPENSKLNINTASPLVLASMDEKLDIGAIEKELQTRQQNLKFFQNVDELWQLNAFSAVDSQRKNQVNSLIDVKSSFFQAQIEVVLNNRKRQFTSALMRKDKQVYVYSRSMAPFN Kraken2_NZ_CP077849.1 IMICODJL_41906 Prodigal:2.6 3036480 3037655 + VFG037807(gb|WP_000013434) 100.0 2.12e-281 (lpxB) lipid-A-disaccharide synthase VF0466 LPS VFC0258 Immune modulation LpxM dependent acylation of lipid A is essential for A. baumannii desiccation survival, a key resistance mechanism for survival in hospital environments Evasion of the host immune response, triggering the host inflammatory response MANRKLKIGIVVGEVSGDTLGVKLMRSFREQGIDAEFEGIGGPQMIAEGFNSYYPMETLSVMGIVEVLKDLKKLFAVRDGLINQWTQHPVDIFIGIDAPDFNLRLSKSIKEKNLPIKTVQYVSPSVWAWRQGRVHGIKQSIDLVLCLFPFEKVFYEQYEVPAAFVGHPLAKQLPLENPIQIAKQELGVDENQKHIALLPGSRKGEVERLLPMLLGAANILHTKYPDIQFLIPAINDARKQQIEQGVEQLAPQLKAKIHILENTDSESKIGRMVMNASDIIALASGTATLEAMLMHRPMVTFYKLHWLTYLIAKFLVKIPYYSLPNIIAGKKVIEELIQADATPENLAAEIEKLMNVETAQIQVMQHLTMHKQLISGNTEDPVQAILQCLNS Kraken2_NZ_CP077849.1 IMICODJL_42083 Prodigal:2.6 3220141 3220998 - VFG013470(gb|WP_011609100) 62.4 1.5899999999999999e-128 (kdsA) 2-dehydro-3-deoxyphosphooctonate aldolase VF0044 LOS VFC0258 Immune modulation Lic1A (phosphorylcholine (ChoP) kinase) 5'-CAAT-3' within the 5'-end of its coding sequence; lic2A, also referred to as lexA, variation in the number of 5'-CAAT-3' repeats has been shown to correlate directly with phase variation of the Gal-alpha(1-4)beta-Gal LPS structure; But lgtC (glycosyltransferase), another phase-variable gene, ultimately dictates whether this structure is synthesized. lic3A encode a sialyl transferase which directs the substitution of LPS with sialic acid. Comprising Lipid A, an inner core of one molecule 3-deoxy-D-manno-oct-2-ulopyranosonic acid (Kdo) and three molecules of heptose, and an outer core composed of a heteropolymer of the neutral sugars glucose and galactose. Substitution of the out core with phosphorylcholine or sialic acid results in the heterogeneity of LPS; Lack O-antigen Major immunogen; LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals; LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments Lic1(lic1A-lic1D) responsible for the addition of phosphorylcholine to LPS. lic1A mediates phase variation (tetranucleotide repeat region); phase-variable gene lic3A encodes an alpha-2,3-sialyltransferase that is responsible for the addition of Neu5Ac to terminal lactose in the LPS, LPS sialylation has been shown to be important for resistance to the killing effectors of normal human serum MSQLKPQEVVRLGDIQMANHLPFVLFGGMNVLESKDLAFEIAETYIDICKRLDIPYVFKASFDKANRSSLHSFRGPGLEKGIEWLGDIKKHFNVPIITDVHEPYQAAPVAEVADIIQLPAFLSRQTDLVEAMAKTQAIINIKKAQFLAPHEMRHILHKCLEAGNDKLILCERGSAFGYNNLVVDMLGFDIMKEMNVPVFFDVTHALQTPGGRSDSAGGRRAQITTLARAGMATGLAGLFLESHPDPDKAKCDGPSALRLSQLEPFLAQLKELDTLVKGFKKLDTH Kraken2_NZ_CP077849.1 IMICODJL_42161 Prodigal:2.6 3298817 3299605 - VFG037792(gb|WP_000064875) 100.0 1.36e-125 (lpxA) acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase VF0466 LPS VFC0258 Immune modulation LpxM dependent acylation of lipid A is essential for A. baumannii desiccation survival, a key resistance mechanism for survival in hospital environments Evasion of the host immune response, triggering the host inflammatory response MSNHDLIHSTAIIDPSAVIASDVQIGPYCIIGPQVTIGAGTKLHSHVVVGGFTRIGQNNEIFQFASVGEVCQDLKYKGEETWLEIGNNNLIREHCSLHRGTVQDNALTKIGSHNLLMVNTHIAHDCIVGDHNIFANNVGVAGHVHIGDHVIVGGNSGIHQFCKIDSYSMIGGASLILKDVPAYVMASGNPAHAFGINIEGMRRKGWSKNTIQGLREAYKLIFKSGLTSVQAIDQIKSEILPSVPEAQLLIDSLEQSERGIVR Kraken2_NZ_CP077849.1 IMICODJL_42163 Prodigal:2.6 3300094 3301164 - VFG037837(gb|WP_000868104) 100.0 4.82e-189 (lpxD) UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase VF0466 LPS VFC0258 Immune modulation LpxM dependent acylation of lipid A is essential for A. baumannii desiccation survival, a key resistance mechanism for survival in hospital environments Evasion of the host immune response, triggering the host inflammatory response MKVQQYRLDELAHLVKGELIGEGSLQFSNLASLENAEVNHLTFVNGEKHLDQAKVSRAGAYIVTAALKEHLPEKDNFIIVDNPYLAFAILTHVFDKKISSTGIESTAQIHPSAVISKTAYIGHYVVIGENCVVGDNTVIQSHTKLDDNVEVGKDCFIDSHVTITGGSKLRDRVRIHSSTVIGGEGFGFAPYQGKWHRIAQLGSVLIGNDVRIGSNCSIDRGALDNTILEDGVIIDNLVQIAHNVHIGSNTAIAAKCGIAGSTKIGKNCILAGACGVAGHLSIADNVTLTGMSMVTKNISEAGTYSSGTGLFENNHWKKTIVRLRQLADVPLTQITKRLDHIQAQIESLESTFNLRK Kraken2_NZ_CP077849.1 IMICODJL_42296 Prodigal:2.6 3414822 3417050 - VFG037177(gb|WP_000632986) 100.0 0.0 (plc2) phospholipase C VF0470 Phospholipase C VFC0235 Exotoxin Contribute to the pathogenesis by aiding in the lysis of host cells, via cleavage of phospholipids present in the host cell membrane, and by degrading phospholipids present at mucosal barriers to facilitate bacterial invasion Lipolytic enzyme that catalyzes the cleavage of phospholipids MITRRKFLNYSLNMGFGAAALAAFPSSIQKALAIPANNKTGTIQDVEHVIILMQENRSFDHYFGTLKGVRGFADRFTIPLPNGRRVWEQLRSNGQVLTPFHLDGTANNAQRADGTPHTWDDSQLAWDNGRMANWPTHKTDISMGYFKEKEIPYQFALANAFTICDAYHCSMHTGTDANRSFHLTGTNGATPTKRSFVNNEWDWIDGNPATADRGYTWKTYAERLEEAGISWICYQNMPDEWGDNMLGAFRSFRKANIASGYPVSSGGEPNKPYADTGQKLPYKAYDAATDNAKNPLYKGIANTLPGNKPEEYLDAFKRDIREGKLPQVSWINAPSIYCEHPDPSSPVQGAWFIQEIIDALTAVPEVWSKTALLINFDENDGYFDHMPSPSAPSRLKNGQYAGKSTLSNADMQDEYFDHAAPEGSHSQPTPDGRVYGPGPRVPLYVISPWSRGGWVNSQVFDHTSVLMFLEKRFGVKEPNISPYRRAVCGDLTSAFNFKTPNADVLPQLSGKQTRLQADALRENQEALPAVPVPTDIKLPIQQSGIRLSRALPYELHTSARCKADGKVQLIFSNTGKQAAVFHVYDKLNLDRIPKRYIVEPNKTLDDEWDALNDNLGRYDLWVLGPNGYHRHFKGDAQRIIDSGVKPEIRVCYDIANGDVYVELMNEGTKDTILTVKPCAYRQDAPLQLTVKAGQVVKQHWSLADVGHWYDFEVTSESDPYYYRRFAGRVETGEDSFSDPAMI Kraken2_NZ_CP077849.1 IMICODJL_42407 Prodigal:2.6 3538706 3539170 - VFG037692(gb|WP_000786639) 100.0 3.81e-109 (pgaD) poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD VF0472 PNAG VFC0271 Biofilm PNAG is produced by the Pga machinery consisting of PgaABCD proteins. Pga complex probably spans the inner and outer bacterial membrane. PgaC and PgaD form an inner membrane-intergrated complex. PgaC is the cataytic glycosyltransferase containing 4-5 predicted transmembrane helices (TMHs). PgaD probably contains two TMHs with a short periplasmic loop and small cytosolic C terminus. PgaA is an outer membrane porin and might associate with PgaB, a periplasmic lipoprotein that is probably anchored to the outer membrane. PgaB deacetylates a small fraction of the polymer's NAG units. Beta-(1-->6)-Poly-N-acetyl-D-glucosamine (PNAG) is a surface polysaccharide produced by many pathogens, including S. aureus, E. coli, Y. pestis, B. pertussis, A. baumannii and others Critical for biofilm formation MKNDANIDVEVLDIPEYIDQPEYVKNKTANYTLQTIGWFCLMWLLFPLVSLFLWIFEGHLIYDYVWVDHVSEVKTLLHLLLLIGLSALILILWASYNWLRFHGDDRRSKAPNSSVELLASQFMVSTESLSELQKSQRIILHYDEQGYLTRYDLK Kraken2_NZ_CP077849.1 IMICODJL_42408 Prodigal:2.6 3539167 3540414 - VFG037678(gb|WP_000866237) 100.0 9.52e-313 (pgaC) poly-beta-1,6 N-acetyl-D-glucosamine synthase VF0472 PNAG VFC0271 Biofilm PNAG is produced by the Pga machinery consisting of PgaABCD proteins. Pga complex probably spans the inner and outer bacterial membrane. PgaC and PgaD form an inner membrane-intergrated complex. PgaC is the cataytic glycosyltransferase containing 4-5 predicted transmembrane helices (TMHs). PgaD probably contains two TMHs with a short periplasmic loop and small cytosolic C terminus. PgaA is an outer membrane porin and might associate with PgaB, a periplasmic lipoprotein that is probably anchored to the outer membrane. PgaB deacetylates a small fraction of the polymer's NAG units. Beta-(1-->6)-Poly-N-acetyl-D-glucosamine (PNAG) is a surface polysaccharide produced by many pathogens, including S. aureus, E. coli, Y. pestis, B. pertussis, A. baumannii and others Critical for biofilm formation MKVLLDILFAFAFLYPLLMAWTWMVGGLWFFFKREYHEQQLPEPSSEGCSIIIPCFNEEAQVRQTIRYALQTKYPNFEVIAVNDGSSDSTAEILDELAAQDARLRVVHLAENQGKAVALRSGVLVSKYEYLVCIDGDALLHPHAVLWLMQPFLNFPRIGAVTGNPRILNRSSILGKLQVGEFSSIIGLIKRAQRTYGRIFTVSGVIAAFRKTALVRVGFWSDDKITEDIDISWKLQMDHWDIQYIPQALCYIYMPETFKGLWKQRLRWAQGGVEVLLEYIPKMFKLRLRRMWPVMLEALVSIIWSYVMIMIFILFFVGLFVDLPQQFQINSLMPQWYGVILGGTCLVQFLVSLWIDHRYDRGRLFRNYFWVIWYPLFFWLLTLFTSVVAVPKTIFNTKKRARWVSPDRGFRGDHS Kraken2_NZ_CP077849.1 IMICODJL_42409 Prodigal:2.6 3540414 3542243 - VFG037664(gb|WP_001061322) 100.0 0.0 (pgaB) poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB VF0472 PNAG VFC0271 Biofilm PNAG is produced by the Pga machinery consisting of PgaABCD proteins. Pga complex probably spans the inner and outer bacterial membrane. PgaC and PgaD form an inner membrane-intergrated complex. PgaC is the cataytic glycosyltransferase containing 4-5 predicted transmembrane helices (TMHs). PgaD probably contains two TMHs with a short periplasmic loop and small cytosolic C terminus. PgaA is an outer membrane porin and might associate with PgaB, a periplasmic lipoprotein that is probably anchored to the outer membrane. PgaB deacetylates a small fraction of the polymer's NAG units. Beta-(1-->6)-Poly-N-acetyl-D-glucosamine (PNAG) is a surface polysaccharide produced by many pathogens, including S. aureus, E. coli, Y. pestis, B. pertussis, A. baumannii and others Critical for biofilm formation MNNLLSKMLGCALVSTLLPLQFAYAQIEKDLPKNHTVSLTFHDVRDGVLKEGDRDIYAIQTKNLAQFFDWLSQSDWKPIRLKDIEEARKQGKELPHNSILLTFDDGALSSYSRVFPLLKQYQIPAVFALPTSWLNGNTQAGYEAYGQGNLVNWKQVREMQASGLAEFASHSDDLHHGVLANPQGNEQPAATSYTYLKSQKRYETDVEYQQRILQDLKKSYAVLKKEVGVEPKAIIWPYGAVNEQLEKLSQEAGFIFSFSLGRDGMNRVSDSTFKRSLVTNNPTAEQLTEGMINILNFEELDLFKQPRHFVSMDLKQLAASTNTQSDEKLGLLLSKLYSLKNNTLILKPLDDQDGDGQYDIAYFPTTQLSVQQDILNRTLWQAQTRAGQSVILELPVYPQKNKPFLVVDLAKDIARFNSNLSGIQLNAGTTLNCAMQSTTIKENACADQLKQLTYVSQLTQKAVKPYLNMSNQAQFSLLLTPDFEHIENLPTLLKTLLSQHDLVNLKFNIVGKQKQFNHVLAILNTLDAKYKQRIMLTLSLPENSQQNAWQEVKQGLFNIQRIGIQKFGIDGYTNENSKNVHEYLYNPISLNSSSVMYQPFAGLATEGKK Kraken2_NZ_CP077849.1 IMICODJL_42410 Prodigal:2.6 3542243 3544681 - VFG037647(gb|WP_000913306) 100.0 0.0 (pgaA) poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA VF0472 PNAG VFC0271 Biofilm PNAG is produced by the Pga machinery consisting of PgaABCD proteins. Pga complex probably spans the inner and outer bacterial membrane. PgaC and PgaD form an inner membrane-intergrated complex. PgaC is the cataytic glycosyltransferase containing 4-5 predicted transmembrane helices (TMHs). PgaD probably contains two TMHs with a short periplasmic loop and small cytosolic C terminus. PgaA is an outer membrane porin and might associate with PgaB, a periplasmic lipoprotein that is probably anchored to the outer membrane. PgaB deacetylates a small fraction of the polymer's NAG units. Beta-(1-->6)-Poly-N-acetyl-D-glucosamine (PNAG) is a surface polysaccharide produced by many pathogens, including S. aureus, E. coli, Y. pestis, B. pertussis, A. baumannii and others Critical for biofilm formation MLKKCVFSLVYLLPIHLYAAQVDVLREQAIQNYRAGQTQQAVSQLDQLLNKYPHDQKLLADYLFIMSSEKRDLTNFSRFLVNINYVDFPEYAKLPLIQNFRDFKHFKTAIDWSNKFNIQKSVDGRILLSVLYAEAQDVANAKDQLSKIDIKGLTADQLVRVAYAYRLINLPVDALATVEHAYQQQTKSSSVLQEYVYDLIAIGSYKKAQQLLQASEKTEQTVQMLQTLQVSEFSQHINNAIARYKYLNREGLADAESFAELDKVLEQGQKIHQQMNPSDPNYLRFYYDYLYGLDFRGRSKAVIENSTQLNIPLEKLPAYVRHAIADSYLAEQKPKKAEFAYKTLLTEKNYPDMTVYTGLYYSYIEQEKYKEAEQLLAEVDRLIPTYKYSQAKGVDKISHPDRDDYIALQGMHLAYANHLDQAEKHFQKKVEQAPANESLINNLARVERWREKPLEAKKTLSRLNGIDPIAKDTRINEMQNAQALGDIPTWRKTTQNLVQYYPDDSGVIKSRKELEDRNRATISHSTTWGQSKAEGRDTVSEQNGLKDREMETRLNSPWINDNYRLFAWHQDRYGEYRFGDVHDQRYGVGAEWQANRKALSAIVSQSTDGGQAGVRLDWSQWLNDHWQYQLQYNSQADIPLQALDAGEDGQSYRAAVTWQKDESRQIGASYSLTDISDGNKQQEFSTFWRERLFDAPHHITYGTVRGFYGTNSQDQTAYFSPSSHYSAELNLSHDWVTWREYERSFKQHFEAGVGLYKQADYSAKPTYSLQYQHQWQLSRTWQLNYGIGWQYHPYDGHDEQHTYGIFGFEGRF Kraken2_NZ_CP077849.1 IMICODJL_42501 Prodigal:2.6 3629520 3629999 - VFG050889(gb|WP_000783000.1) 100.0 3.47e-103 (gspM) general secretion pathway protein M VF1335 T2SS VFC0086 Effector delivery system Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB Secretes multiple effectors that were shown to be required for virulence in vivo, including the lipoyl synthases LipA and LipH as well as the protease CpaA MKMLAQLQNRFDQWVEQIVQYLDRLTVRERIMVVFTTIFVVVVIVGYSLWKMHSLAEQQQKRLNDLKDLMVWMQSNAVTMKPANELELDKSGKIQRVAQQQGLTVSSQQNGEQLQIVVTHQNYAILANFLTQLAQMGLSIQKMEMVSSEGQIKLTATVQ Kraken2_NZ_CP077849.1 IMICODJL_42502 Prodigal:2.6 3629999 3631138 - VFG050874(gb|WP_001989189.1) 100.0 2.4399999999999997e-274 (gspL) general secretion pathway protein L VF1335 T2SS VFC0086 Effector delivery system Although the T2SS machinery is conserved across Acinetobacter spp., the effector repertoire is diverse and varies from strain to strain;Secretion of type II effectors, CpaA and LipA, require specific membrane-associated chaperones, CpaB and LipB Secretes multiple effectors that were shown to be required for virulence in vivo, including the lipoyl synthases LipA and LipH as well as the protease CpaA MLYIWMPETNGVWHWSNGENWLQAASLDQLIQDLQIHQGKEATVFFPSRHAQMLQQTMAKSHYKQLGADGVKYLLEEFVTLPIDHMKVVHHFHADQLTVLGVAQGVVETWQHSLALLPTKLVALLPDFLVLPEPQAQQVILCNIDHQLLVRENKWLGNSIDDLGLFLEFQSAETHYQYSGLTAEQLESLEAASSAEQRSEFVYQFQPLDKTKQHPFNVLPKSKGQERTFSSYWKACAAVVLAIIVVQFSYDLLRWVKLKKVADQTAEQAIEQYKYWFGPSSRVTEQNIKGQFESHLRMSQQGDTQALSLLSRVGPILMQRQILAQQLNYDASILTMALKAKSADDLQALTQQLNQQGFKAELGNVQADGNGAIGVVKIQ Kraken2_NZ_CP032827.1 IMICODJL_43005 Prodigal:2.6 215696 217102 - VFG043573(gb|NP_219906) 66.5 4.12e-206 (dnaK) chaperone protein DnaK VF0713 Adherence; porin VFC0001 Adherence MSKVIGIDLGTTNSCVAVMDGKETRVIENSEGARTTPSIVAFAENGERLVGQAAKRQSITNPTNTIYSVKRLMGRRYDDPVAAKDKSLVPYAIVSGDNGDAWVETRGRKYPPSQISAFILGKMKETAEAYLGEAVTQAVITVPAYFNDAQRQATKDAGRIAGLEVLRIINEPTAAALAYGLDKKTSGRIAVYDLGGGTFDISILEIGDGVFEVKSTNGDTFLGGEDFDGRVIDFLATEFQKEQGIDLRTDKLALQRLKEAAEKAKIELSSAKETEINLPFITADASGPKHLLIKLTRAKLEALVDDLIQRTMEPCKAALKDAGVTAADIDEVVLVGGMTRMPKVIEVVRAFFSKEPARNVNPDEVVAIGAAIQGAVLRGDVKDVLLLDVTPLSLGIETLGGVFTRLIDRNTTIPSKKSQTFSTADDNQAAVTIKVFQGEREMAADNKALGNFDLTGIQPAPAACHRSR Kraken2_NZ_CP120364.1 IMICODJL_43295 Prodigal:2.6 193099 193980 + VFG005898(gb|WP_002904719) 63.7 3.32e-131 (rfbA) glucose-1-phosphate thymidylyltransferase RfbA VF0144 Capsule VFC0258 Immune modulation Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages Resistant to complement deposition and masks cell wall-associated complement from being recognized by the complement receptors on phagocytes MKGIILAGGRGTRLYPVTISVSKQLLPVHDKPMIYYPLGMLMLAGIREILVITMPRDRPLFEELLGDGSQFGLAISYAEQPEPNGLAEAFIIGRDFIGNSSVALILGDNIFYGAGLPELCSDAAARPSGATIFAYRVDDPERYGVVSFDGETGRAETIEEKPERARSSWAVTGLYFYENSVLEIASSIKPSARGELEITDVNRAYLERGDLHVCRLGRGYAWLDTGTHDSLHDAASFVRTIEHRQGVKIMCPEEIAFELGYVSADQVLERADLLGKNDYAIYLRRRVRELSDA Kraken2_NZ_CP120364.1 IMICODJL_43386 Prodigal:2.6 288377 290005 - VFG045692(gb|WP_197532029) 66.9 1.4099999999999999e-241 (htpB) Hsp60, 60K heat shock protein HtpB VF0159 Hsp60 VFC0001 Adherence Mediate a complement-independent attachment to mammalian and amoebal host cells Specific receptors have not been identified MAAKEVKFQTDARERMLRGVDVLANAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELEDKFENMGAQMLREVASRTNDLAGDGTTTATVLAQAIVREGAKAVASGMNPMDLKRGIDLAVDAVVKELKNNARKISKNSEIAQVGTISANGDTEIGRYLAEAMEKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNQDKMRVELEDPYILIHEKKLSNLQAMLPVLEAVVQSGKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDVAILTGGTVVSEDLGIKLESVTLDMLGRAKKVSIEKENTTIIDGAGSKAEIEGRTAQIRAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDALHATRAAVEEGILPGGGVALLRAVKALDGLKTANNDQRVGVDLVRRAIEAPVRQIAENAGAEGSIIVGKLREKTEFSYGWNAQTNEYGDLYAMGVIDPAKVVRTALQDAASVAGLLVTTEAMIAEKPKKEAAPALPAGGGMDF Kraken2_NZ_CP120364.1 IMICODJL_43616 Prodigal:2.6 521364 522137 + VFG002704(gb|WP_002208597) 61.7 3.26e-119 (rfbF) glucose-1-phosphate cytidylyltransferase VF0392 O-antigen VFC0258 Immune modulation Clinical Y. enterocolitica isolates from humans predominantly belong to serotypes O:3, O:9, O:8 and O:5,27; Y. enterocolitica O antigen expression is temperature regulated. LPS O antigen mutants were severely impaired in their ability to colonize the Peyer's patches and did not colonize spleen and liver. The absence of O antigen in the outer membrane affects the expression of other Yersinia virulence factors. MGMKVVILAGGYGTRISEESHLRPKPMIEIGGRPILWHIMKIYSHYGFSNFVICLGYRGYMIKEYFSNYVLHSSDVTFDMATGETAYHTKSAEPWRVTLVDTGPESMTGGRLKRVAGYLGDTFCLTYGDGVADVDVRALTEFHLRHGREATVTSVVPPGRYGALATEAGQVMSFTEKPAGDNGRINGGFFVLNRSVLDRIEGDHVPFESAPLEGLARDGQLMAFPHDGFWRPMDTLRDKTQLEELWQQNRAPWKIWA Kraken2_NZ_CP120364.1 IMICODJL_44344 Prodigal:2.6 1274380 1275672 + VFG043535(gb|WP_004686048) 85.3 2.2300000000000002e-276 (ugpB) sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB VF0694 SP41 VFC0001 Adherence MRLISISTTIAFGFAFQAQAATELQWWHAMTGANNEMIEELTKEFNESQSTYKVVPVFKGTYPETLNAGIAAFRSKQPPAIIQVFDAGSGTMMAAEGAIVPAAEILQKGGFTFDKSQYLPGIVAYYSKPDGTMLSFPYNSSSPILYYNKDAFQKAGLNVDNPPKTWPEVFEAAKKIKTSGAAPCGMTSTWLTWIQTENFAAWNNVPYGTNENGLGGTDVKLQINAPLYVEHFQAIADLAKDGAFRYGGRTSEAKQLFTSGECAILTESSGGLGDIAKSGVNYGIGQLPYYEGHGPQNTIPGGASLWVFAGKSDEEYKGVAEFFNFLSQTEIQAKLHQVSGYMPVTMAAYEETKKSGFYEKNPGRETPLLQMMGKAPTENSKGVRLVNLPQVRDILNEEFEAMLSGQQDAKTALDKAVERGDAAIAAAISN Kraken2_NZ_CP120364.1 IMICODJL_44383 Prodigal:2.6 1314011 1315057 + VFG017989(gb|WP_002867010) 61.0 7.92e-139 (C8J_RS06930) SDR family oxidoreductase VF0323 Capsule VFC0258 Immune modulation Major antigenic component of the classic Penner serotyping system; Variation in the capsule structure may cause by multiple mechanisms, such as exchange of capsular genes and entire clusters by horizontal transfer, gene duplication, deletion, fusion and the presence of homopolymeric G tracts in several cps genes The capsule consists of repeating oligosaccharide units attached to a dipalmitoyl-glycerophosphate lipid anchor; The CPS is extensively substituted with variable O-methylphosphoramidate, methyl, ethanolamine, and N-glycerol groups Play an important role in bacterial survival and persistence in the environment and evasion of host immune response; the presence of heptose residues in the capsule may be important for virulence. Heptose residues found in some cell surface-located glycoconjugates are required for adhesion MNYFRNDFRGTLFGTNDDTDSLRRRSLQKRILVTGGAGFLGSHLCELLLGAGHEVICLDNFSTGLMCNIAPLKRFDTFRVIAHDVVEPIDLEVDEIYNLACPASPPHYQADPIQTTKTCVIGSLNLLDLAARRGARIFQASTSEIYGDPHVHPQVESYWGNVNPFGPRSCYDEGKRCAETLFFDFHKFHEVEIKIVRIFNTYGPRMRPDDGRVVSNFIVQALKGEDITIYGDGSQTRSFCFVDDLIDGFVRLMASPPSLTGPVNLGNPAEFTIGELAEEVIRLTGSRSKIVRRPLPVDDPRQRRPDISLATEELGWRPKVNLTEGLAHTIRYFDDLLSRSMRESAELV Kraken2_NZ_CP120366.1 IMICODJL_44635 Prodigal:2.6 23633 24487 - VFG018745(gb|WP_012232413) 65.2 2.7599999999999997e-119 (vbhB9) P-type conjugative transfer protein VirB9 VF0680 VirB-homolog (vbh) type IV secretion system VFC0086 Effector delivery system MRTTFIATLLLTAAASTALALEIPRGAAQDSRVRFVDYQPYNITRIIGSLRSSVQVEFAPDEEIAHVALGNSVAWEVAPAGNILFLKPRENQPVTNISVVTTRRDGSTRSYQMELTVRDGKVEVGQNTYFYVKYRYPADEAERRRQAAAARAIAAQAKEADNVLAIHEAYGPRNWRYSAQGAQALEPQSVYDNGKVTTFAFVGNQEMPAIYIENSDGSESLVPKSVDGNLVLVHAISRKFILRRGGDVLCVFNEAYDHVGINPDTNTTSPSVERIVRIDAGAVQ Kraken2_NZ_CP120366.1 IMICODJL_44641 Prodigal:2.6 27342 29738 - VFG018691(gb|WP_012232117) 62.4 0.0 (virB4) type IV secretion system virB4 protein homolog VF0369 VirB/VirD4 type IV secretion system VFC0086 Effector delivery system The VirB/VirD4 T4SS is well conserved within the genus Bartonella, although it is absent in B. bacilliformis. Its closest relative is a genuine conjugation system, the AvhB/TraG system of the cryptic plasmid pATC58 of Agrobacterium tumefaciens; The Bartonella VirB/VirD4 system is encoded by an operon of 10 genes (virB2-virB11). Seven Bartonella-translocated effector proteins (BepA-BepG) and the coupling protein VirD4 are encoded within 22 kb downstream of the virB operon. The entire virB/virD4/bep region probably constitutes a pathogenicity island The Bartonella VirB/VirD4 system is considered to encompass a VirB2 pilin and VirB5 minor pilus component, which form a pilus that can mediate contact with host cells. The components VirB3, VirB4 and VirB6-VirB11, which form a pore complex that spans both Gram-negative membranes and possibly also the host-cell membrane. And the T4SS coupling protein (T4CP) VirD4, an inner-membrane protein thought to function as an interface between the pore complex and the T4SS substrates Crucial for establishment of infection in the primary niche- the endothelial cells, required for colonization of endothelial cells, by mediating the intracellular delivery of effector proteins (BepA-BepG). Translocation of the Beps provokes distinct cellular phenotypes: (i) a massive cytoskeleton rearrangement, resulting in the engulfment of bacterial aggregates (a phenotype called 'invasome' formation), (ii) NF-kappaB-dependent proinflammatory activation, characterized by chemokine secretion and expression of cell adhesion proteins, and (iii) enhanced cell survival as a result of anti-apoptosis (iv) capillary-like sprout formation of endothelial cell aggregates The Bartonella-translocated effector protein (BepA-BepG) are required for invasion, proinflammatory activation and anti-apoptotic protection of endothelial cells. The C terminus of each Bep harbours at least one copy of the novel Bep intracellular delivery (BID) domain and a short, positively charged tail sequence. The bipartite C terminus is required for protein transfer, their N-terminal region might be crucial for effector function within host cells.; The N termini of BepA-BepC comprise the Fic (filamentation induced by cAMP) domain, which is conserved in many bacteria and was proposed to be involved in bacterial cell division. The effector functions of the Fic domain within mammalian target cells are unknown.; The N termini of BepD-BepF contain short repeated peptide sequences that contain conserved putative tyrosine-phosphorylation motifs (EPLYA). Future studies might show how tyrosine-phosphorylated Beps contribute to the subversion of endothelial-cell function. BepG is unique among the Beps because it appears to be entirely composed of BID domains.; Invasome formation can be triggered in a redundant manner, either by BepG alone or by the combined action of effectors BepC and BepF. MKGTSDLPSLTTLRSRELGPETFIPYVRHVDESTIALDSRALMVMIALEGVSFETADILDLNALHRDLNTLYRNIADERLALWTHLIRRRDNSYPEGTFATPFSAALNDKYRERMVGEDLFRNDLYLSILWSPARDPADKAAKLLSRLRRARRVGTELDEDALKHLRDKVTDVTAALRRFEPRVLTLYEHDGLMFSEPSEVLHQLVGGRREPIPLTEGRIASAIYSDRVIVGRETIEIRHEADSRYAGMLSFKEYPARTRTGMLDAVLTSPFELILAQSFSFVSKADARMIMGRKQNQMVSSGDKAASQIEELDGAMDDLESNRFVFGEHHLTLSVFAPSVKELTDNLAKARASMTSGGAVVAREDLGLEAAWWAQLPGNFRYRARSGAITSRNFAALSPFHSYPLGQKDGNQWGPAVALLKTASGSPYYFNFHYGDLGNTFVCGPSGAGKTVLLNFMLSQLEKHDPHVVFFDKDRGADLYVRAAGGTYLPLKNGIPTGCTPLKALELTPENKVFLTRWVGKLVGSATRELSVTELRDIASAIDGLADLPVERRTIGALRTFLDNTNPEGIAARLRRWERGGPLGWVFDNVIEDIGFGEFGGGKFVGYDMTDFLDNEEIRAPLMAYLFHRVEQLIDGRRIIIVVDEFWKALQDEGFRDLAQNKLKTIRKQNGLMLFATQSPRDAIVSPIAHTIIEQCPTQIFLPNSRGNHGDYVDGFKLTEREFELVARELSIESRRFVLKQGHNSVVAELDLKGLDDELAILSGRTANVELADAIRAEVGSNAKDWLPVFQQRRSAT Kraken2_NZ_CP120366.1 IMICODJL_44921 Prodigal:2.6 308792 309634 - VFG013732(gb|WP_006769637) 62.5 2.24e-112 (fagC) ABC transporter ATP-binding protein VF0741 ABC transporter VFC0272 Nutritional/Metabolic factor MTDHLLVASGLTAGYDKTEILHALDLTIPPGKITVIVGANACGKSTFLRALSRLIAPSKGQVLLDGKSIHRTPPRDLARTLGLLPQSPIAPEGITVVDLVSRGRHPHQSLFSRWTRQDDEAVDSALTATKTFDLAERPIDELSGGQRQRVWIAMALAQQTEILLLDEPTTFLDINHQIEVLDLLTDLNSTRGTTVVMVLHDLNLAARYADHLVAIAGGRVHISGTPEEVLTEETVRHVFGLDSRVISDPTSGRPIMLPIGRHRMAVIDDMGDAPQKERSA Kraken2_NZ_CP120366.1 IMICODJL_45165 Prodigal:2.6 528500 530146 + VFG041365(gb|WP_010974920) 80.1 0.0 (virD4) type IV secretion system ATPase VirD4 VF1257 VirB/VirD system VFC0086 Effector delivery system MCSLAVGFCGASAYSTFRFGFDGRALMTFDILAFWYETPFYLGYTTLFFYRGLAVVVLTSGAILFVQQMVSVRDRQHHGTARWARVDEMRRAGYLQRYSRISGPVFGKTSGPFWSDYYLTNSEQPHSLIVAPTRAGKGVGIVIPTLLTYEGSVIALDVKGELFDLTSRARKARGDSVFKLAPLDPERRTNCYNPLLDIVALPSERQFTEARRLAANLIATKGQSAEGFINGARDLFVAGILACIERGTPTIGAVYDLFAQPGEKYSLFARLAQETQNKEAQRIFDEMASNDTKILTSYTSVLGDGGLNLWADPLIKAATSRSDFSIYDLRRRRTCIYLCVSPNDLEVVAPLMRLLFQQVVSILQRSLPGKDEKHEVLFLLDEFKHLGKLEAIETAITTIAGYKGRFMFIIQSLSALTGTYEESGKQNFLSNTGVQVFMATADDETPVYISKAIGEYTFQARSTSYTQSLTFDRNIQNSDQGAPLLRPEQVRLLPDKYQIVLIKGQPPLQLRKVRYYSDRALKRIFDSQTGRLPEPAPLMIADERFSHV Kraken2_NZ_CP120366.1 IMICODJL_45231 Prodigal:2.6 570484 572121 + VFG010484(gb|WP_197535716) 67.3 1.8099999999999998e-242 (htpB) Hsp60, 60K heat shock protein HtpB VF0159 Hsp60 VFC0001 Adherence Mediate a complement-independent attachment to mammalian and amoebal host cells Specific receptors have not been identified MAAKEVKFGRSAREKMLRGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASKTNDIAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDLAVAEVVKDLLAKAKTINTSDEVAQVGTISANGEKQIGLDIAEAMQKVGNEGVITVEEAKTAETELEVVDGMQFDRGYLSPYFVTNPEKMVADLEDAVILLHEKKLSNLQAMLPVLEAVVQTGKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGTVISEDLGIKLESVTLDMLGRAKKVSITKENTTIVDGAGQKSDIEGRVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRIDDALNATRAAVQEGIVPGGGVALLRSSVKITVKGENDDQDAGVNIVRRALQSPARQIVENAGDEASIVVGKILEKDTDDFGYNAQTGEYGDMIAMGIIDPVKVVRTALQDAASVASLLITTEAMIAELPKKDAPAMPGGMGGMGGMDMM Kraken2_NZ_CP120366.1 IMICODJL_45428 Prodigal:2.6 749598 751781 - VFG024100(gb|WP_014711614) 67.5 0.0 (katG) catalase/peroxidase HPI VF0303 KatG VFC0282 Stress survival Catalase:peroxidase degrades H2O2 and organic peroxides, the major role is to catabolize the peroxides generated by phagocyte NADPH oxidase MDQKSDSAGKCPVAHTAPRGRSNRDWWPDQLDVQVLHRHSGLSDPLGNTFNYAEEFKKLDLDALKRDLHALMTDSQDWWPADFGHYGGLFIRMAWHSAGTYRITDGRGGAGQGQQRFAPLNSWPDNANLDKARRLLWPIKQKYGNRISWADLLILTGNVALESMGFKTFGFAGGRVDVWEPEELFWGPEGTWLGDERYSGERQLSEPLAAVQMGLIYVNPEGPNGNPDPVAAAHDIRETFARMAMNDEETVALIAGGHTFGKTHGAGDPSFIGADPEGGAIEDQGLGWKSTFGTGVGKDAITGGPEVTWSQTPTRWSNHFFENLFNHEWELTKSPAGAHQWKAKNAEATIPDAYDASRKHVPTMLTTDLSLRFDPAYEKISRRFLENPDQFADAFARAWFKLTHRDMGPKVRYLGPEVPAEDLIWQDVIPAVDHRLVDETDIAGLKAKILASGLSVQELVSTAWASASTFRGSDKRGGANGARIRLAPQKDWEVNQPTQLARVLSVLEGIQRDFNAAQTGGKKISLADLIVLAGGAAVEKAAKAGGHDISVPFTPGRMDATEAQTDAASFAALEPRADGFRNYVSTTRQQFMKPEEALVDRAQLLTLTAPEMTVLVGGLRVLKAGEPKHGVFTSRPEALTNDFFANLLDMGTQWSPIEGEEGVYEGRDRKTGAARWTGTRVDLIFGSHSQLRAFAEVYAQSDAREKFVKDFVAAWTKVMNADRFDLV Kraken2_NZ_CP120366.1 IMICODJL_45513 Prodigal:2.6 828117 829751 - VFG001855(gb|WP_197535493) 62.3 9.45e-223 (htpB) Hsp60, 60K heat shock protein HtpB VF0159 Hsp60 VFC0001 Adherence Mediate a complement-independent attachment to mammalian and amoebal host cells Specific receptors have not been identified MSAKQIVFSTDARDRLLRGVELLNNAVKVTLGPKGRNVVIDKSYGAPRITKDGVSVAKEIELEDKFENMGAQMVRAVASKTNDLAGDGTTTATVLAASIFREGAKLVSVGMNPMDLKRGIDLGVAAVLAEIKARATKVISSSEIAQVGTIAANGDAGVGEMIARAMEKVGNEGVITVEEARTADTELDVVEGMQFDRGYLSPYFVTNAEKMRVELEDPYILIHEKKLGSLQAMLPILEAAVQSGKPLLIISEDVEGEVLATLVVNRLRGGLKIAAVKTPGFGDRRKAMLEDIAVLTAGQMISEDLGIKLENVTLDMLGRARRVLIEKDTTTIIDGSGDKASIQARVSQIKAQIEETASDYDKEKLQERLAKLAGGVAVIRVGGATELEVKEKKDRIDDALNATRAAVEEGIVPGGGVALLRAKSALVGLTDDNADVTAGISIVRRALEAPIRQIADNAGVEGSIVVGKLVDGRDHNQGFDAQTETYVDMIKAGIVDPAKVVRTALRDAGSIASLLITAEAMIADIPERGSPQSTGNGAVDSMGY Kraken2_NZ_CP120366.1 IMICODJL_45876 Prodigal:2.6 1152563 1154200 - VFG010484(gb|WP_197535716) 67.5 2.72e-244 (htpB) Hsp60, 60K heat shock protein HtpB VF0159 Hsp60 VFC0001 Adherence Mediate a complement-independent attachment to mammalian and amoebal host cells Specific receptors have not been identified MAAKEVKFGRSAREKMLRGVDILADAVKVTLGPKGRNVVIDKSFGAPRITKDGVTVAKEIELEDKFENMGAQMVREVASKTNDIAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDLAVAEVVKDLLAKAKTINTSDEVAQVGTISANGEKQIGLDIAEAMQKVGNEGVITVEEAKTAETELEVVDGMQFDRGYLSPYFVTNPEKMVADLEDAFILLHEKKLSNLQAMLPVLEAVVQTGKPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAMLEDIAILTGGTVISEDLGIKLESVTLDMLGRAKKVSITKENTTIVDGAGQKSDIEGRVAQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRIDDALNATRAAVQEGIVPGGGVALLRSSVKITVKGENDDQDAGVNIVRRALQSPARQIVENAGDEASIVVGKILEKNTDDFGYNAQTGEYGDMIAMGIIDPVKVVRTALQDAASVASLLITTEAMIAELPKKDAPAMPGGMGGMGGMDMM Kraken2_NZ_CP050161.1 IMICODJL_46228 Prodigal:2.6 51643 53283 - VFG045692(gb|WP_197532029) 74.5 3.8400000000000004e-271 (htpB) Hsp60, 60K heat shock protein HtpB VF0159 Hsp60 VFC0001 Adherence Mediate a complement-independent attachment to mammalian and amoebal host cells Specific receptors have not been identified MAAKDIRFGEDARSKMVRGVNVLANAVKATLGPKGRNVVLQKSYGAPTITKDGVSVAKEIELADAFENMGAQMVKEVASKTSDNAGDGTTTATVLAQAFIREGMKAVAAGMNPMDLKRGIDQAVKAAVGELKSLSKPSSTSKEIAQVGAISANSDANIGDLIAQAMDKVGKEGVITVEEGSGLDNELDVVEGMQFDRGYLSPYFVNNQQSMSADLDDPFILLYDKKISNVRDLLPVLEGVAKAGKPLLIVAEEVEGEALATLVVNTIRGIVKVCAVKAPGFGDRRKAMLEDMAILTGGVVISEEVGLSLEKATIKDLGRAKKIQVSKENTTIIDGAGEGAGIEARIKQIKAQIEETSSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALIRAKAAIAGIKGVNEDQNHGIQIALRAMEAPLREIVTNAGDEPSVILNRVVEGSGAFGYNAANGEFGDMIEFGILDPTKVTRTALQNAASIAGLMITTEAMVAEAPKKDEPAMPAGGGMGGMGGMDF Kraken2_NZ_CP050167.1 IMICODJL_46322 Prodigal:2.6 72115 74313 - VFG033944(gb|WP_000973519) 99.9 0.0 (iutA) ferric aerobactin receptor precusor IutA VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNIDHIEVISGATSLYGGGSTGGLINIVTKKGQPETMMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTERHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAVFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIAAGKATSADAIPGGSVDYDNFLFNAGLLMHITERQQAWLNFSQGVELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTVDLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF Kraken2_NZ_CP050167.1 IMICODJL_46323 Prodigal:2.6 74398 75675 - VFG033958(gb|WP_000750130) 100.0 0.0 (iucD) L-lysine 6-monooxygenase IucD VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MKKSVDFIGVGTGPFNLSIAALSHQIEELDCLFFDEHPHFSWHPGMLVPDCHMQTVFLKDLVSAVAPTNPYSFVNYLVKHKKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVENIDFDKKRRLFLVQTSQGEYFARNICLGTGKQPYLPPCVKHMTQSCFHASEMNLRRPDLSGKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISGFSGLEEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLESSGPGWKLLMEHHLDQGRESLESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDDFTLEWSGPKENNIFVVNASMQTHGIAEPQLSLMAWRSARILNRVMGRDLFDLSMPPALIQWRSGT Kraken2_NZ_CP050167.1 IMICODJL_46324 Prodigal:2.6 75672 77414 - VFG012522(gb|WP_001015721) 100.0 0.0 (iucC) aerobactin siderophore biosynthesis protein IucC VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MNHKDWDLVNRRLVAKMLSELEYEQVFHAESQGDDRYCINLPGAQWRFIAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKQVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLINLNADRLQCLLSGHPKFVFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMIWRCDNEMDIHQLLTAAMDPQEFARFSQVWQENGLDHNWLPLPVHPWQWQQKIATDFIADFAEGRMVSLGEFGDQWLAQQSLRTLTNASRRGGLDIKLPLTIYNTSCYRGIPGRYIAAGPLASRWLQQVFATDATLVQSGAVILGEPAAGYVSHEGYAALARAPYRYQEMLGVIWRENPCRWLKPDESPVLMATLMECDENNQPLAGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKEGVPQRVLLKDFQGDMRLVKEEFPEMDSLPQEVRDVTSRLSADYLIHDLQTGHFVTVLRFISPLMVRLGVPERRFYQLLAAVLSDYMKKHPQMSERFALFSLFRPQIIRVVLNPVKLTWPDLDGGSRMLPNYLEDLQNPLWLVTQEYES Kraken2_NZ_CP050167.1 IMICODJL_46325 Prodigal:2.6 77414 78361 - VFG033993(gb|WP_000011910) 100.0 1.2900000000000002e-248 (iucB) aerobactin siderophore biosynthesis protein IucB VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MSGANIVHSGYGLRCEKLDKPLNLGWGLDNSAVLHWPGELPTGWLCDALDQIFIAAPQLSAVVLPWSEWCEEPQALTLFGQVQSDIIHRSAFWQLPLWLSSPANRASGKMVFDAEREIYFPQRPPRPQGEVYRRYDPRIRRMLSFRIADPVSDAERFTRWMNDPRVEYFWEQSGSLEVQIAYLERQLTSKHAFPLIGCFDDRPFSYFEIYWAAEDRIGRHYSWQPFDRGLHLLVGEQQWRGAHYVQSWLRGVTHYLLLNEPRTQRTVLEPRTDNQRLFRHLEPAGYRTIKEFDFPHKRSRMVMADRHHFFTEVGL Kraken2_NZ_CP050167.1 IMICODJL_46326 Prodigal:2.6 78362 80086 - VFG012526(gb|WP_000602863) 100.0 0.0 (iucA) aerobactin siderophore biosynthesis protein IucD VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MILPSEKSATDVAAQCFLNALIRETKDWQLAEYPPDELIIPLDEQKSLHFRVAYFSPTQHHRFAFPAHLVTASGSYPVDFTTLSRLIIDKLRHQLFLPVPLCETFHQRVLESYAHTQQTIDARHDWAILREKALNFGEAEQALLTGHAFHPAPKSHEPFNRQEAERYLPDMAPHFPLRWFSVDKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLHPWQGEYLLQQVWCQALFAKGLIRDLGEAGTSWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVERGMRLARLAQTDGWQMLQARFPTFRVMQEDGWAGLRDLNGNIMQESLFSLRENLLLEQPQSQTNVLVSLTQAAPDGGDSLLVSAVKRLSDRLGITVQQAAHAWVDAYCQQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGFIYRDCQGSAFMPHATEWLDTIDEAQAENIFTREQLLRYFPYYLLVNSTFAVTAALGAAGLDSEANLMARVRTLLAEVRDQVTHKTCLNYVLESPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLQAQEV Kraken2_NZ_CP050167.1 IMICODJL_46331 Prodigal:2.6 83418 84275 - VFG012590(gb|WP_000968139) 100.0 1.78e-190 (sitD) iron/manganese ABC transporter permease subunit SitD VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MMALLLEPLQFTFMSHALLISLVVSIPCALLSVFLVLKSWALMGDAMSHAVFPGIVLAWILGLPLATGAFVAGVFCAVATGYLKDNSRIKQDTVMGIVFSGMFAAGLILYIAVKPDVHLDHILFGDMLGITIGDIIQTVIIAGLVTLVISVKWRDFLLFSFDYQQAQASGLHTRWLHYGLLCMVSLTIVATLKAVGIILSISLLIAPGAIAVLLTQRFHIALLLATGISILVSMTGVWLSFFIDSAPAPTIVVLFAVMFIMTFTVTSINARTKENAEPRDLLSSD Kraken2_NZ_CP050167.1 IMICODJL_46332 Prodigal:2.6 84272 85129 - VFG012585(gb|WP_001101723) 100.0 1.48e-198 (sitC) iron/manganese ABC transporter permease subunit SitC VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MNVLLEPFSYEYMLNAMWVSAMVGGLCAFLSCYLMLKGWSLIGDALSHSIVPGVAGAYMLGLPFSLGAFFSGGLAAGSMLFLNQLTRLKEDAIIGLIFSSFFGLGLFMVSLNPTSVNIQTIVLGNILAIDPADILQLTIIGILSIIVLFFKWKDLMVTFFDENHARAIGLHPGRLKILFFTLLSVSTVAALQTVGAFLVICLVVTPGATAWLLTDRFPRLLMIAVTIGSVTSFLGAWVSYFLDGATGGIIVVAQTLLFLLAFVFAPTHGLLANRRRAHKALEDRS Kraken2_NZ_CP050167.1 IMICODJL_46333 Prodigal:2.6 85126 85950 - VFG034214(gb|WP_000983710) 100.0 3.3500000000000003e-192 (sitB) iron/manganese ABC transporter ATP-binding protein SitB VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MQSAGIVVNDVTVTWRNGHTALRDASFTVPGGSIAALVGVNGSGKSTLFKAIMGFVRLTSGKISVLGIPTRQALQKNLVAYVPQSEEVDWSFPVLVEDVVMMGRYGHMGMLRIAKKRDRQIVTDALERVDMVDFRHRQIGELSGGQKKRVFLARAIAQQGDVILLDEPFTGVDVKTEAKIISLLRELRAEGKTMLVSTHNLGSVTTFCDYTVMVKGTVLASGPTDTTFTAENLELAFSGVLRHVTLNGSEESIITDDERPFVAHRPSAVQREER Kraken2_NZ_CP050167.1 IMICODJL_46334 Prodigal:2.6 85953 86867 - VFG012575(gb|WP_000949004) 100.0 4.37e-221 (sitA) iron/manganese ABC transporter substrate-binding protein SitA VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MLSIKKVTMLLGCLVLTCSIAFQASAAEKFKVITTFTIIADMAKNVAGDAAEVSSITKPGAEIHEYQPTPGDIKRAQGAQLILANGMNLELWFQRFYQHLNGVPEVIVSSGVTPVGITEGPYEGKPNPHAWMSPDNALIYVDNIRDAFIKYDPANAQTYQRNADTYKAKITQTLAPLRKQIAELPENQRWMVTSEGAFSYLARDLGLKELYLWPINADQQGTPQQVRKVVDIVKKNHIPAVFSESTISDKPARQVARETGAHYGGVLYVDSLSTENGPVPTYIDLLKVTTSTLVQGIKAGKREK Kraken2_NZ_CP050167.1 IMICODJL_46383 Prodigal:2.6 129234 129797 + VFG042713(gb|WP_001296758) 100.0 1.51e-122 (fimA) type 1 fimbrial major subunit FimA VF1153 F9 fimbriae VFC0001 Adherence MKLKHVGMIVVSVLAMSSAAVSAAEGDESVTTTVNGGVIHFKGEVVNAACAIDSESMNQTVELGQVRSSRLAKAGDLSSAVGFNIKLNDCDTNVSSNAAVAFLGTTVTSNDDTLALQSSAAGSAQNVGIQILDRTGEVLILDGATFSAKTDLIDGTNILPFQARYIALGQSVAGTANADATFKVQYL Kraken2_NZ_CP050167.1 IMICODJL_46384 Prodigal:2.6 130158 130868 + VFG042714(gb|WP_001195169) 98.3 4.76e-166 (Z_RS10335) fimbria/pilus periplasmic chaperone VF1153 F9 fimbriae VFC0001 Adherence MQITRTPYSVSFMATVLLLLLFACHSTVANAAVALGATRVIYPANQKQVLLPVTNNDPASVYLIQSWIENAGDQKDTQFVITPPLFSMQGKKENTLRIINATNHQLPGDRESLFWVNVKAIPAMEKDQKNENTLQLAIISRIKMFYRPTNLAMAPEEAPAMLRFRRSGSKLTLINPTPYFITVTNMKAGNSNLPNTMVPPKGEVSVDIPHAASGDISFQTINDYGALTPRIKATMQ Kraken2_NZ_CP050167.1 IMICODJL_46385 Prodigal:2.6 130910 133561 + VFG033280(gb|WP_000125356) 96.7 0.0 (fimD) Outer membrane usher protein fimD precursor VF0221 Type 1 fimbriae VFC0001 Adherence Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases FimC-FimH chaperone adhesin complex: 1QUN Makes an important contribution to colonization of the bladder FimH is the adhesin protein binding to mannose-containing glycoprotein receptors, known as uroplakins, which are located on the luminal surface of the bladder epithelial cells. This binding is followed by invasion of uroepithelia cells MTAFRAAFKAYRMHQVLILPRFARLTFALGLATAVFPVDAEYYFNPRFLSNDLAESVDLSAFTKGREAPPGTYRVDIYLNDEFMTSRDITFIADDNNADLIPCLSTDLLVSLGIKKSALLDNKEHSAEKHVPDNSACTPLQDRLADASTEFDVGQQHLSLSVPQIYVGRMARGYVSPELWEEGINAGLLNYSFNGNSINNRSNHNAGKSNYAYLNLQSGINIGSWRLRDNSTWSYNSGSSNSSDSNKWQHINTSAERDIIPLRSRLTVGDSYTDGDIFDSVNFRGLKINSTEAMLPDSQHGFAPVIHGIARDTAQVSVKQNGYDVYQTTVPPGPFTIDDINSAANGGDLQVTIKEADGSIQTLYVPYSSVPVLQRAGYTRYALAMGEYRSGNNLQSSPKFIQGSLMHGLEGNWTPYGGMQIAEDYQAFNLGIGKDLGLFGAFSFDITQANTTLADGTRHSGQSIKSVYSKSFYQTGTNIQVAGYRYSTQGFYNLSDSAYSRMSGYTVKPPTGDSNEQTQFIDYFNLFYSKRGQEQISISQQLGNYGTTFFSASRQSYWNTSRSDQQISFGLNVPFSDITTSLNYSYSNNIWQNDRDHLLAFTLNVPFSHWMRTDSQSAFRNSNASYSMSNDLKGGMTNLSGVYGTLLPDNNLNYSVQVGNTHGGNTSSGTSGYSSLNYRGAYGNTNIGYSRSGDSSQIYYGMSGGIIAHADGITFGQPLGDTMVLVKAPGADNVKIENQTGIHTDWRGYAILPFATEYRENRVALNANSLADNVELDETVVTVIPTHGAIARATFNAQIGGKVLMTLKYGNKSVPFGAIVTHGENKNGSIVAENGQVYLTGLPQSGKLQVSWGNDKNSNCIVGYKLPAVSPGTLLNQQTAICR Kraken2_NZ_CP050167.1 IMICODJL_46386 Prodigal:2.6 133575 134105 + VFG033311(gb|WP_000876770) 99.4 1.32e-122 (fimF) FimF protein precursor VF0221 Type 1 fimbriae VFC0001 Adherence Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases FimC-FimH chaperone adhesin complex: 1QUN Makes an important contribution to colonization of the bladder FimH is the adhesin protein binding to mannose-containing glycoprotein receptors, known as uroplakins, which are located on the luminal surface of the bladder epithelial cells. This binding is followed by invasion of uroepithelia cells MKYNNIIFLGLCLGLTTYSALSADSVIKISGRVLDYGCTVSSDSLNFTVDLQKNSARQFPTTGSTSPAVPFQITLSECSKGTTGVRVAFNGIEDAENNTLLKLDEGSNTASGLGIEILDGNMRPVKLNDLHAGMQWIPLVPEQNNILPYSARLKSTQKSVNPGLVSASATFTLEFQ Kraken2_NZ_CP050167.1 IMICODJL_46387 Prodigal:2.6 134118 134621 + VFG033335(gb|WP_000825461) 97.6 2.32e-114 (fimG) FimG protein precursor VF0221 Type 1 fimbriae VFC0001 Adherence Mannose-sensitive (MSHA) fimbriae, the ability to hemagglutinate erythrocytes was blocked by the presence of mannose; the genes responsible for type I fimbriae are found in almost all subgroups of E.coli, not just in UPEC strains, but the fimbriae function as a virulence factor in the pathogenesis of E.coli UTI; Expression of type I fimbriae undergoes phase variation controlled at the transcriptional level by invertible element. The sigma70 promoter for FimA is located within this 314bp invertible DNA element flanked on both ends by inverted DNA repeats of 9bp in length. Leucine-responsive protein (LRP), integration host factor (IHF), and the histone-like protein (H-NS) affect the switching of the invertible element by binding to DNA sequences around and within the invertible element region, thus assisting or blocking the switching actions of the FimB and FimE recombinases FimC-FimH chaperone adhesin complex: 1QUN Makes an important contribution to colonization of the bladder FimH is the adhesin protein binding to mannose-containing glycoprotein receptors, known as uroplakins, which are located on the luminal surface of the bladder epithelial cells. This binding is followed by invasion of uroepithelia cells MKRLHKRFLLATFCTLFTATLQAADVTITVNGRVVSKPCTIQTKEANVNLGDLYTRNLQQPGSASGWHNITLSLTDCPIETSAVTAIVTGSTDNTGYYKNEGTAENIQIELRDDQDATLKNGDSKTVIVDEITRNAQFPLKARAITVNGNASQGTIEALINVIYTWQ Kraken2_NZ_CP050167.1 IMICODJL_46388 Prodigal:2.6 134681 135595 + VFG042718(gb|WP_000520684) 97.7 5.7100000000000005e-217 (ydeQ) fimbrial protein VF1153 F9 fimbriae VFC0001 Adherence MGKTISIKVLFGIYFLLMAGKVFAFSCNVDGGSSIGAGTTSVYVNLDPVIQPGQNLVVDLSQHISCWNDYGGWYDTDHINLVQGSAFAGSLQSYKGSLYWNNVTYPFPLTTNTNVLDIGDKTPMPLPLKLYITTVGAAGGVVIKAGEVIARIHMYKIATLGSGNPRNFTWNIISNNSVVMPTGGCTVDSRNVTVDLPDFPGSAEIPLGVYCSSEQKLSFYLSGATTDSARQVFANTAPDATKASGVGVSLIRNGKILATGENVSLGTVNKSKVPLGLSATYGQTGNKVAAGAVQSVIGVTFIYE Kraken2_NZ_CP051736.1 IMICODJL_46892 Prodigal:2.6 25053 26228 + VFG036084(gb|WP_001020413) 100.0 1.33e-284 (senB) enterotoxin production-related protein TieB VF1136 Enterotoxin SenB/TieB VFC0235 Exotoxin MNIFTLSKAPLYLLISLFLPTMAMAIDPPERELSRFALKTNYLQSPDEGVYELAFDNASKKVFAAVTDRVNREANKGYLYSFNSDSLKVENKYTMPYRAFSLAINQDKHQLYIGHTQSASLRISMFDTPTGKLVRTSDRLSFKAANAADSRFEHFRHMVYSQDSDTLFVSYSNMLKTAEGMKPLHKLLMLDGTTLALKGEVKDAYKGTAYGLTMDEKTQKIYVGGRDYINEIDAKNQTLLRTIPLKDPRPQITSVQNLAVDSASDRAFVVVFDHDDRSGTKDGLYIFDLRDGKQLGYVHTGAGANAVKYNPKYNELYVTNFTSGTISVVDATKYSITREFNMPVYPNQMVLSDDMDTLYIGIKEGFNRDWDPDVFVEGAKERILSIDLKKS Kraken2_NZ_CP051736.1 IMICODJL_46957 Prodigal:2.6 81585 82271 - VFG001445(gb|AAA92657) 100.0 6.42e-147 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MCALDRRERPLNSQSVNKYILNVQNIYRNSPVPVCVRNKNRKILYANGAFIELFSREDKPLSGESYIRLQVEIFLSSLELECQALGHGSAFCRRFNFHGEIYQIRMENVSFYNDESVVLWQINPFPDYPFFALNQSGSNTNTSDKLTIWNDLSPGTLVVFSFYMLGVGHATIARELGITDRASEDRIKPVKRKIKEFFEHFDLFRVSCIYKGEIDSLLSIIREFYGVK Kraken2_NZ_CP051699.1 IMICODJL_47113 Prodigal:2.6 27292 31407 + VFG000903(gb|WP_001045652) 98.8 0.0 (pic) Pic serine protease precursor, autotransporter VF0232 Pic VFC0086 Effector delivery system Homologous to the Pic protein identified in Shigella flexneri and enteroaggregative E. coli Protease, mucinase MNKVYSLKYCPVTGGLIVVSELASRVIKKTCRRLTHILLAGIPAVCLYYPQISQAGIVRSDIAYQIYRDFAENKGLFVPGATDIPVYDKDGKLVGRLDKAPMADFSSVSSNGVATLVSPQYIVSVKHNGGYQSVSFGNGKNTYSLVDRNNHSSVDFHAPRLNKLVTEVIPSAITSEGTKANAYKDTERYTAFYRVGSGTQYTKDKDGNLVKVAGGYAFKTGGTTGVPLISDATIVSNPGQTYNPVNGPLPDYGAPGDSGSPLFAYDEQQKKWVIVAVLRAYAGINGATNWWNVIPTDYLNQVMQDDFDAPVDFVSGLAPLNWTYDKTSGTGTLSQGSKNWTMHGQKDNDLNAGKNLVFSGQNGAIVLKDSVTQGAGYLEFKDSYTVSAESGKTWTGAGIITDKGTNVTWKVNGVAGDNLHKLGEGTLTINGTGVNPGGLKTGDGTVVLNQQADTAGNVQAFSSVNLASGRPTVVLGDARQVNPDNISWGYRGGKLDLNGNAVTFTRLQAADYGAVITNNAQQKSRLLLDLKAQDTNVSVPIGSISPFGGTGTPGNLYSMILNGQTRFYILKSASYGNTLWGNSLNDPAQWEFVGTDKNKAVQTVKDRILAGRAKQPVIFHGQLTGNMDVTIPQLPGGRKVILDGSVNLPEGTLSQDSGTLIFQGHPVIHASVSGSAPVSLNQKDWENRQFTMKTLSLKDADFHLSRNASLNSDIKSDNSHITLGSDRAFVDKNDGTGNYVIPEEGTSVPDTVNDRSQYVGNITLNHNSALDIGSRFTGGIDAYDSAVSITSPDVLLTAPGAFAGSSLTVHDGGHLTALNGLFSDGHIQAGKNGKITLSGTPVKDTANQYAPAVYLTDGYDLTGDNAALEITRGAHASGDIHASAASTVTIGSDTPAELASAETAASAFAGSLLEGYNAAFNGAITGGRADVSMHNALWTLGGDSAIHTLTVRNSRISSEGDRTFRTLTVNKLDATGSDFVLRTDLKNADKINVTEKATGSDNSLNVSFMKDPAQGQSLNIPLVTAPAGTSAEMFKAGTRVTGFSRVTPTLHVDTSGGNTKWILDGFKAEADKAAAAKADSFMNAGYKNFMTEVNNLNKRMGDLRDTNGDAGAWARIMSGAGSADGGYSDNYTHVQVGFDKKHELDGVDLFTGVTMTYTDSSADSHAFSGKTKSVGGGLYASALFESGAYIDLIGKYIHHDNDYTGNFAGLGTKHYNTHSWYAGAETGYRYHLTEDTFIEPQAELVYGAVSGKTFRWKDGDMDLSMKNRDFSPLIGRTGIELGKTFSGKDWSVTARAGTSWQFDLLNNGETVLRDASGEKRIKGEKDSRMLFNVGMNAQIKDNMRFGLEFEKSAFGKYNVDNAVNANFRYMF Kraken2_NZ_CP051699.1 IMICODJL_47120 Prodigal:2.6 35295 44387 - VFG036031(gb|WP_000554183) 67.8 0.0 (cdiA) contact-dependent inhibition effector tRNA nuclease VF1131 Contact-dependent inhibition CDI system VFC0086 Effector delivery system MHQPPVRFTYRLLSYLISTIIAGQPLLPAVGAVITPQNRAGMDKAANGVPVVNIATPNGAGISHNRFTDYNVGKEGLILNNATGKLNPTQLGGLIQNNPNLKAGGEAKGIINEVTGGNRSLLQGYTEVAGKAANVMVANPYGITCDGCGFINTPHATLTTGRPVMNADGSLQALEVTEGSITINGAGLDGTRSDAVSIIARATEVNAALHAKDLTVTAGANRVTADGRVSALKGEGDVPKVAVDTGALGGMYARRIHLTSTESGVGVNLGNLYARDGDITLDASGRLTVNNSLATGAVTAKGQGVTLTGDHKAGGNLSVSSRRDIVLSNGTLNSDKDLSLTAGGRITQQNEKLTAGRDVTLAAKNITQDTASQINAARDIVTDASDTLTTQGQITAGQNLTASATTLTQDGILLAKGHAGLDAGTLNNSGAVQGASLMLGSTTLSNSGSLLSGSRLTVNTHEFNQSGHTGAKGKVDITASGKLTSTGSLVSDDALVLKAQNVTQNGVLSGGKGLTVSAQTLSSGKKSVTHSDAAMTLNVTTVALDGETSAGDTLRVQADKLSTAAGAQLQSGKNLSINARDARLAGTQAAQQTMVVNASEKLTHSGKSSAPSLSLSAPELTSSGVLVGSALNTQSQTLTNSGLLQGEASLTVNTQRLDNQQNGTLYSAADLTLDIPDIRNSGLITGDNGLTLNTASLSNPGKIIADTLSVRATTLDGDGLLQGAGALALAGDTLSQGSNGRWLTAGDLTLRGKILNTAGTTQGQNLTVQADNWANSGSVLATGNLTASATGQLTSTGDIMSRGDTTLKAATTNNRGSLLSAGTLSLDGNSLDNSGTVQGNHVTIRQNSVTNSGTVTGLSGLTLHSADGLTNSGALLSQNSLTLSAGDVTNSGRIQGRNITLDASSLTSSGAVQSALDLALTLNGDVIAATGSKITALGDARLTGKVLGNQGLISAKTLEVNGDSLSNGGEISGVNSLNVTLSGNLQQHGKMLTGGALNVNARDISNSGQLQGADNRITASSLTNSGRVQGDSGLTLTLLNALTNQTSGVLLSQNAFVLTAPVLTNNGTIQGNGKTTLSAATQAHNSGKILSGGDLTFTTPDYSGSGWLQATDLLLNVAKLAGNGTVMAANQATLTGNSLTNRGLFQAAQLNVNTQTITNSGTLLGNQGLTIKGNSLNNAGGKVFSGGDMLADMVSLSGAGQLVALGNLTLKLTSGLTAQGVIAANKQLSVSSQGDITNGATLQGNGITLNAAGRLTNNGQLTAGNGTTVLSGSGIAMNASGSLQAGGDVSLTSRGDITLDGFTGTTGSLVLTVAGAVINTALLYAGNNLSLFASTIRNHHGDMLAGDSLVMQKDVSGAANAEVINTSGNIETTRGDITIRTGHLLNQREGINETKSYIPVENVAVPDGANSVSVRVGDLGEDGWGYYVKSWSGTAGGGFEAWAVPTEKGATRKFLTGTTRVDVGATGGDARISAGNNLLIDANKLDNTGSHLLASEFVSLSGSQLNNQSFFGYTQDEYNVYRYYGKLAMIPNDGHLQYGDASADDRVTFTLSGAPEYVTRDTGQALRAVIQAGKNVTAVFSSDISNTSTTSNAGRITNTLAAPEINTPAEKNISPGMAQLAQDGTETLTVTAPDWTDTITRLTIGSGTDLASGIVEGNYPLPSGNNGYFVPSTDPDSPYLITVNPKLDGLGKVDSSLFAGLYDLLRMHPGQAPRETDPAYTDEKQFLGASYFLDRLGLKPEKDYRFLGDAAFDTRYVSNYMLNQIGGRYIYGVGSDTDQMRYLMDNAARAQKALGLKFGVALTADQVAALDRSILWYKAVTINGQTVMVPEVYLSPKDVTLQNGSIISGQNVRLAGGNVTNSGSTLMAQNNLTRYSHWQLDAPEDSLALKHTYTGSIASVSAMDSLDIRADKNISVTGAEISAGGRAALIAGNDLSLNAIDRVSSSRHANSESHQRSAGLTTITAGDSVMLSAGRDVSSQAAGIAAEDNITVRAGRDVNLLAEESVTGSSSYSKRKTVIDETVRQQGAEIASGGDTTVTAGRDITAVASSVTATGNISVNAGRDVALTTATESDYHYLETKKKSGGFLSKKTTHTISEDSATREAGSLLSGNRVTVNAGDNLTVEGSDVVADRDVSLAAGNHVDVFAATSTDTSWRFKETKKSGLMGTGGIGFTIGSSKTTHDRREAGTTQSQSASTIGSTAGNVSITAGKQAHISGSDVIANRDISITGDSVVVDPGHDRRTVDEKFEQKKSGLTVALSGTVGSAINNAVTSAQETKESSDSRLKALQATKTALSGVQAGQAAAMATATGDPNAMGVSLSLTTQKSKSQQHSESDTVSGSTLNAGNNLSVVATGKNRGDNRGDIVIAGSQLKAGGNTSLDAANDVLLSGAANTQKTTGRNSSSGGGVGVSIGAGGNGAGISVFASVNAAKGSEKGNGTEWTETSIDSGKTVTINSGRDTVLNGAQVNGNRIIADVGHDLLISSQQDTSKYDSKQTSVAAGGSFTFGSMTGSGYIAASRDKMKSRFDSVAEQTGMFAGDGGFDITVGRHTQLDGAVIASTATPDKNHLDTGTLGFSDLHNEADYKVSHSGISLSGGGSFGDKFQGNMPGGMISAGGHSGHAEGTTQAAVAEGTITIRDRDNQKQNLANLSRDPVHANDSISPIFDKEKEQRRLQTVGLISDIGSQVADIARTQGELNALKAAQDKYGPVPADATEEQRQAYLAKLRDTPEYKKEQEKYGTGSDMQRGIQAATAALQGLAGGNMAGALAGASAPELAHLLKSTEKDPAVNAIAHAILGGAVAAMQGNNVAAGAAGAATGELAARAIAGMLYPGVKQSDLSEEQKQTISTLATVSAGLIGGLTGNSTVSTAVGAQSGKNAVENNALGNKNDRLPPIIPINPLPIGVEGADGEPLKGGGGIAKGGKSKDTQIWTETKKVEPVGNAYGHWTKHGKEFPEYQNAKQYVDAVHNFVTNPPAGTLMTVRKNGDTIYYNPSSNIFAVKNADGVPKTMFKPNPEEHGYKTNLDYFNAQK Kraken2_NZ_CP051699.1 IMICODJL_47121 Prodigal:2.6 44400 46172 - VFG036039(gb|WP_001305333) 97.6 0.0 (cdiB) ShlB/FhaC/HecB family hemolysin secretion/activation protein VF1131 Contact-dependent inhibition CDI system VFC0086 Effector delivery system MQHRQKIILTKTSLLFRAVSVPCYDMFRHGSPWICYLSLSVFSGFFIPAFSSPAAMLSPGDRSAIQQQQQQLLDENQRQRDALERSAPLTITPSPETSAGTEGPCFTVSRIVVSGATRLTSAETDRLVAPWVNQCLNITGLTAVTDAVTDGYIRRGYITSRAFLTEQDLSGGVLHITVMEGRLQQIRAEGADLPGRTLKMVFPGMEGKVLNLRDIEQGMEQINRLRTEPVQIEISPGDREGWSVVTLTASPEWPVTGSVGIDNSGQKNTGTGQLNGVLSFNNPLGLADNWFVSGGRSSDFSVSHDARNFAAGVSLPYGYTLVDYTYSWSDYLSTIDNRGWRWRSTGDLQTHRLGLSHVLFRNGDMKTALTGGLQHRIIHNYLDDVLLQGSSRKLTSFSVGLNHTHKFPGGVGTLNPVFTRGMPWFGAESDHGKRGDLPVNQFRKWSVSASFQRPVTDRVWWLTSAYAQWSPDRLHGVEQLSLGGESSVRGFKEQYISGNNGGYLRNELSWSLFSLPYVGTVRAVTALDGGWLHSDSDDPYSSGTLWGGAAGLSTTSGHVSGSFTAGLPLVYPDWLAPDHLTVYWRVAVAF Kraken2_NZ_CP051699.1 IMICODJL_47169 Prodigal:2.6 84894 85580 - VFG001445(gb|AAA92657) 98.5 7.19e-144 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MCALDRRERPLNSQSVNKYILNVQNIYRNSPVPVCVRNKNRKILYANGAFIELFSREDKPLSGESYIRLQVEIFLSSLELECQALGHGSAFCRRFNFHGEIYQIRMENVSFYNDESVVLWQINPFPDYPFFALNQSVSNTNTSGQLTIWNDLSPGTLVVFSFYMLGVGHATIARELGITDRASEDRIKPVKRKIKEFFEHFDLFRVSCIYKGEIDSLLSIIREFYGVK Kraken2_NZ_CP051699.1 IMICODJL_47180 Prodigal:2.6 92976 93662 - VFG042529(gb|AAC28317) 69.1 4.78e-119 (afrC) chaperonin precursor VF1146 Adhesive factor/rabbit 1 (AF/R1) pili VFC0001 Adherence MNKVAKTAIAAVLSFVFCSQAMAAFVLNGTRFIYDENKKNITFEVTNNASQTYGGQVWVDNTSEGNSIYMVPQPPFFKVGAKQKQIIRIMKTDSSLPVERESLFWLNVQEVPPKPDIKEGSVLAIAMNSRVKLIYRPSNIKDGRENAEKKLTMEQKGGITWIKNPTPYYMAIVGVQTNGKELKLNDQVTKELTQLAPFSSVSLGVSVRGNLKVAAINDWGGVQNYEIH Kraken2_NZ_CP051699.1 IMICODJL_47181 Prodigal:2.6 93655 96057 - VFG042528(gb|AAC28316) 68.3 0.0 (afrB) usher protein precursor VF1146 Adhesive factor/rabbit 1 (AF/R1) pili VFC0001 Adherence MNLSLPKISLLAMSIYTHLGYATDLNLDFIQGTSIIPSILKYDYAYPQGQYSVDVFVNNEKTGTAELNISQEDEKNNMLCFSPKWINSADIMLDTNKYDDVYNREKNCYELAKKNHTRVFFDYSAQKLFFDIPQAYLLSKSDPSRWDYGVTGGRLKYYANFNKTTNGRLDAFGNFELGFNVGRWVLSSNINVSHSGGETEFTSSDMTLSTAISQIQGDLLLGKSQTQTELFSDFNFYGVSVRSNSNMRPWETRGYAPDISGIASGPSRITVAQNGYTIYSRIVPAGPYRLDDLRPTGNGDLVVTLEDDNGHKTVQIYPVTTLPTLLRPGDFQYDFAMGKKNQSNELNKTFSSDTGLFWLGSVDYGFSSATLNSAMLLNNRYQSAGIGVTKPFGELGVLSLSAQTAKAHYNNGDEKKGQNVSIKYAKNFTDRTDLQLMTYRYQDKGYVDYAEFDPHRSFIHGNQKSRYEARLSHRFDTTYLSGAWWHQNYWNRDGSDTGATLSLSTSAFNSVSVFLSGSYNRYANTGKADYSASVSVSIPFDFRGVQHYSSNSVGYNRSSGSTFNTNISASVNDRVNYNLNADLSSRGQRGASALASYAFDAVQTNIGVSQTHSRQGEGQTTFSGGVSGSVLGTSETGPLFTKESSDTIAIISVPGISGIKFNNSMPTDRNGNTVVWLSEYAENSININMENVPDDMDFSTTSYKVVPTEKAMVYRKFGFENVLRYILRVKDKQGKYLTGGEVTTDQGLNAGFISTNGVLLMNVLAEPEKIRIDMGNGMQCHFSMKGLQANTNKVQEIRCE Kraken2_NZ_CP051220.1 IMICODJL_47308 Prodigal:2.6 11500 12657 - VFG042432(gb|CAA54117) 63.2 1.22e-169 (afaC-III) AFA-III usher protein VF0212 Afa/Dr family VFC0001 Adherence Afa/Dr family including afimbrial adhesins AfaE-I, AfaE-III and Dr-II as well as the fimbrial Dr and F1845 adhesins Receptor is the DAF (decay-accelerating factor (CD55)), a cell-surface glycosylphosphatidylinositol-anchored protein that normally protect cells from damage by complement system. The third short consensus repeat (SCR-3) domain of DAF plays a pivotal role in binding adhesins; another receptor is the membrane-associated GPI-anchored protein, the carcinoembryonic antigen (CEA), which belongs to CEACAMs family; inducing a cytopathic effect characterized by the development of long cellular extensions that wrap around the adherent bacteria. (All members of the Dr family including UPEC elicit this effect); binding of Dr adhesins is accompanied by the activation of several signal transduction cascades, including activation of PI-3 kinase MLGKINHSLPNVLDSYRDSRTGSFDHSENKLRRTTLNLTQPLGVLGSVSLYGSRDEYRGNRAKQDSVGVTLGGSWNNISWSVNGSRNRNFGLYKGQEGKTENRISLWMSVPLERWLGNAANDIRATTQILKSSGQKTRYEVGMNGNAFDRRLYWDISEEMVPGSENSSDNSRLNLRWQGTYGELTGMYGYSSHMRQISAGISGGMIAHSEGITLGQKTGDTTALVVAPGVSGASVEGWPGVKTDYRGYTLAGYMSAYQENVITMDPSTFKENAEVVRTDTKVIPTKGAVVKANFETRVGARTLITLTRHDGSPVPFGSVVTLEEEKESHPSVGVMGNNGEVYMSGLPKKGNLKVVWGEKNQCNASYQLPEQKGTAGIFLASSVCM Kraken2_NZ_CP051220.1 IMICODJL_47314 Prodigal:2.6 16611 20108 - VFG036043(gb|WP_001038844) 99.7 0.0 (aatA) autotransporter outer membrane beta-barrel domain-containing protein VF1133 AatA, AIDA-I type VFC0001 Adherence MNKNIRILQFLVSILYSVQSHFSGAQTIQLNGNGIPESITRSITGVDGNAALNISVPYTTSYTQNILSVESSINIKGGTSNTSIGGAGVYGENFTLNNNGSVWGGDGYNGGVAVSGNKISINNYRNVYGGNGLGGSGSSGGAGLSGDDIIVDNYRSIYGGDDLGGTGGSGVTGSNITVHNSGGIWGGNGVNGGDGINGSNLFITNDNMISGGYGIKQGGDAISGNQITLNNNGIVQGGYGPDGSCSVYGEDIHINNHGNISGSYNSQKDAYNTSIIFSAGYNSLDIYSDSVINGDIKLASIPVNGTNELIIKNINNATAINGGLMIGNGSSVYLSGKNIIFNGNISIDEDASMNLSAGNANVHANTITLKSDSWLNIDTSIKNWTQDYYTLLSSDTGISIADNSHIVQYNVLLTEGAESYVYTSLNDDDNKLISMLRWNNTKGMGYGTFNIEKDATLNIGVSLSDNLSPLLYDGWDGKSLTKSGNGTLILSATNNYTGNTEVKSGVLILAAPDALGRTEYLYLSRGAELDMNGYPQTISKLLTAAGSVLNIHGGSLILNNGGESAGTIAGDGSLNINGGMLDITGNNRNFSGVFTVNKGAQLAVSTADNLGTAFVDNYGTLTLNSTSAWQLTNNISGYGNVRKTGAGALNISDNAKWTGMTDIIQGTLILGNADSPVMLGSNQVIVEEQGKLSGFGGVAGNLSNSGIVDLTTYMPGNILTVGGNYTGRNGLILLQTETGGDNSKTDRLVIKGNASGRTRVAVTQAGGTGAETLNGIEVIHVSGNADNAEFIQTERITAGAYDYILKRGQGINSTNWYLISRKDIPVPQPEAVPENHDNNLRPEAGSYVASIAAANNLFVTNLYERQGQELYISHMTGEENEAGIWMYNKGKHNRWRDNSSQLRTRGNSYVVLIGGDIAQWSLNGTDCWHTGMMAGYGHNHNSTNALSTGYHSEGRMNGYTAGLYATWYANDETHNGSYLDSWLQYSWFDNHINGERLPAESWKSKGFTVSLEAGYSWKAGEFTDNYKGSHEWYVQPQLQVVRMNVKSDKHRESNGTSIENTGNGNILTRLGARTWFVSKNGKNSRYAVPLRPFVEVNWLHNSRVFGTSMNGVSIYQDGAHNIGEINGGVVGVITPEVVLRADAGIQLGEHGYRNASAMFGVEYRF Kraken2_NZ_CP051220.1 IMICODJL_47344 Prodigal:2.6 45285 46040 + VFG046077(gb|WP_001522323) 65.4 9.25e-117 (afaB) Dr fimbrial biogenesis chaperone DraB VF1139 Afimbrial adhesin AFA-I VFC0001 Adherence MNRCGIFIVVWGLLGFPLHSAATETKIDATSKTFILHLGATRVIYNPSGNGSTLSVYNNQDYPMLVQSEVLAEDRKGKAPFVVTPPLFRLDGLQSSRLRIVRTGGVFPEDRESLQWLCVKGIPPKSGDRWADDKNRNKADDRVSLQMNFSVNSCIKLIIRPDSVKGHPEDVAGNVVWQKTGNKLIGTNPTPFYINLSELSVGGKKVESRHYIAPFSTYEYDIPVSTAGNVYWKVITDYGGNSKQFEAKPKS Kraken2_NZ_CP051220.1 IMICODJL_47345 Prodigal:2.6 46168 48726 + VFG042425(gb|CAW30799) 67.6 0.0 (afaC-I) usher AfaC VF0223 Dr adhesins VFC0001 Adherence The Dr family of adhesins of E. coli is associated with urinary tract infections (UTI), in particular cystitis and pregnancy-associated pyelonephritis, and diarrhoeal disease; The Dr family includes fimbrial adhesins, such as the Dr haemagglutinin (O75X adhesin) and F1845, and afimbrial adhesins, such as AFA-I, AFA-II, AFA-III, AFA-IV, Nfa-I and Dr-II Facilitates colonization The Dr adhesins bind to the Dr blood group antigen (Dra) present on decay accelerating factor (DAF) of erythrocytes and other cell types. DAF is a membrane protein that prevents cell lysis by complement; inducing a cytopathic effect characterized by the development of long cellular extensions that wrap around the adherent bacteria. (All members of the Dr family including UPEC elicit this effect); binding of Dr adhesins is accompanied by the activation of several signal transduction cascades, including activation of PI-3 kinase MAFFKTKVAMFVMAMCSICHANSGVERTYSFDSTLLNSDAKNVDLTLFEAGAQLPGTYHVDIILNDSIVESREMFFHTAQDSEGKTYLKTCLTRDMLIRYGVKTEMYPELFHTSGKKNNVGAEEDCADLSVIPHATEMFQFASQQLRLGIPQAALRPPLRGIAPEALWDDGITAFLMNWQANVSQSEYRKYGHSVSDNFWASIEPGFNLGPWRVRNLMTWSKSSDQPGNWETVYTRAERGVNNMKSRLTLGDDYTPSDIFDSLPFRGIMLGSDESMVPYNQRAFAPVVRGVARTQARIEVRQNGYLIQSQTVAPGAFALTDLPLTSSGGDLQVTVLESDGTTQVFTVPFTTPAVALREGYMKYNVTMGQYRPSDSAVEHSLLGQLTSIYGLPYGLTVFGGVQMAEHYLAGALGGGWSLGGLGAISVDSIYARSQLKGKDNEAGNTWRIRYNKSFELTDTSFTVASYQYSSAGYHSLPNVLDSYRDSRTGSFDHSENKLRRTTLNLTQPLGVLGSVSLYGSRDEYRGNRAKQDSVGVTLGGSWNNISWSVNGSRNRNFGLYKGQEGKTENRISLWMSVPLERWLGNAANDIRATTQILKSSGQKTRYEVGMNGNAFDRRLYWDISEEMVPGSENSSDNSRLNLRWQGTYGELTGMYGYSSHMRQISAGISGGMIAHSEGITLGQKTGDTTALVVAPGVSGASVEGWPGVKTDYRGYTLAGYMSAYQENVITMDPSTFKENAEVVRTDTKVIPTKGAVVKANFETRVGARTLITLTRHDGSPVPFGSVVTLEEEKESHPSVGVMGNNGEVYMSGLPKKGNLKVVWGEKNQCNASYQLPEQKGTAGIFLASSVCM Kraken2_NZ_CP051220.1 IMICODJL_47383 Prodigal:2.6 73242 73928 + VFG001445(gb|AAA92657) 98.0 5.91e-143 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MCALDRRARPLNSQSVNKYILNVQNIYRNSPVPVCVRNKNRKILYANGAFIELFSREDKPLSGESYIRLQVEIFLSSLELECQALGHGSAFCRRFNFHGEIYQIRMENVSFYNDESVVLWQINPFPDYPFFALNQSVSNTNTSGQLTIWNDLSPGTLVVFSFYMLGVGHATIARELGITDRASEDRIKPVKRKIKEFFEHFDLFRVSCIYKGEIDSLLSIIREFYGVK Kraken2_NZ_CP051224.1 IMICODJL_47798 Prodigal:2.6 22247 23362 + VFG012515(gb|WP_001318220) 100.0 1.3600000000000001e-276 (iroB) glucosyltransferase IroB VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MRILFVGPPLYGLLYPVLSLAQAFRVNGHEVLIASGGQFAQKAAEAGLVVFDAAPGLDSEAGYRHHEAQRKKSNIGTQMGNFSFFSEEMADHLVEFAGHWRPDLIIYPPLGVIGPLIAAKYDIPVVMQTVGFGHTPWHIKGVTRSLTDAYRRHNVGATPRDMAWIDVTPPSMSILENDGEPIIPMQYVPYNGGAVWEPWWERRPERKRLLVSLGTVKPMVDGLDLIAWVMDSASEVDAEIILHISANARSDLRSLPSNVRLVDWIPMGVFLNGADGFIHHGGAGNTLTALHAGIPQIVFGQGADRPVNARVVAERGCGIIPGDVGLSSNMINAFLNNRSLRKASEEVAAEMAAQPCPGEVAKSLITMVQKG Kraken2_NZ_CP051224.1 IMICODJL_47799 Prodigal:2.6 23502 27161 + VFG012512(gb|WP_001111199) 100.0 0.0 (iroC) ATP binding cassette transporter VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MPANHTPTPAQSWIVRLARVCWERKKLSVIVVVASVSTILLAALTPLLTRQAVNDALAGNPARLPWLACGLLLIAFFDFIGNYVRRGYAGMLSLWVQHTLRGRVFDSIQKLDGAGQDALRTGQVISRTNSDLQQVHTLLQMCPVPLAVFTYYIAGIAVMLWMSPAMTLIVVCVLVCLAITALRARRRVFAQTGLASDQLANLTEHIREVLAQISVVKSCVAEMRETHWLDRQSRQIVRVRIGAVISQAMPGATMLALPVLGQIVLLCYGGWSVMHGRIDLGTFVAFASFLAMLTGPTRVLASFLVIAQRTQASVERVFALIDTRSQMEDGTESINSQVVGLELENMSFDYHHGDRHILSNISFSLRAGETVAVVGASGSGKSTLLMLLARFYDPCSGKIWLNTSEGRQNLRDIRLEALRRRVGIVFEDAFLFAGTVAENIAYGHPQATADDIRRAAAAAGASDFINALPKGFDSLLTERGTNLSGGQRQRIALARALITAPDVLILDDTTSAVDAVTEAEINTALGRYADEGHMLLVIARRRSTLQLASRVVVLDKGRMVDTGTPAELEARCPAFRALMTGDSDFLATSHNSHNELWPAEPATQDDVTDTGDKGFVARMTRVPENAVQQALAGKGRKVTSLLKPVAWMFVIAALLIALDSAAGVGVLILLQHGIDSGVATGDMSIIGLCALLALCLVIVGWCSYSLQTVFAARAAESVQHSVRLRSFGHMLRLGLPWHEKHADSRLTRMTVDVDSLARFLQNGLAGAATSLVTMFAIAATMFWLDPFLALTALSAVPVAALATMIYRRLSTPAYAQARLEIGKVNSTLQEKVSGLRVVQSHGQQELEGARLRALSERFRATRVRAQKYLAVYFPFLTFCTEASYAAVLLVGASQVAAGEMTAGVLAAFFLLLGQFYGPVQQLSGIVDAWQQATASGKHIDELLATEGTEHLGSSSVLPVTGALHLDEVTFSYPDSHEPALNKLTLTIPEGMVVAVVGRSGAGKSTLIKLIAGLYFPTHGNIRIGVQMLDDASLTEYRRQIGLVDQDVALFSSDIAENIRYSRPSATNEDVEIASQRAGLYEMVCNLPQGFRTPVNNGGADLPAGQRQLIALARAQLANAHILLLDEATSCLDRTSEERLMSSLTDVVHAGKHSALIVAHRLTTAQRCDLIAVIDKGLLAEYGTHEQLLSAGGLYTRLWHDSVSSTALHRQHNMKEETPG Kraken2_NZ_CP051224.1 IMICODJL_47800 Prodigal:2.6 27265 28494 + VFG012508(gb|WP_000933675) 100.0 2.71e-309 (iroD) esterase VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MLNMQQHPSAIASLRNQLAAGHIANLTDFWREAESLNVPLVTPVEGAEDEREVTFLWRARHPLQGVYLRLNRVTDKEHVEKGMMSALPETDIWTLTLRLPASYCGSYSLLEIPPGTTAETIALSGGRFATLAGKADPLNKMPEINVRGNAKESVLTLDKAPALSEWNGGFHTGQLLTSMRIIAGKSRQVRLYIPDVDISQPLGLVVLPDGETWFDHLGVCAAIDAAINNGRIVPVAVLGIDNINEHERTEILGGRSKLIKDIAGHLLPMIRAEQPQRQWADRSRTVLAGQSLGGISALMGARYAPETFGLVLSHSPSMWWTPERTSRPGLFSETDTSWVSEHLLSAPPQGVRISLCVGSLEGSTVPHVQQLHQRLITAGVESHCAIYTGGHDYAWWRGALIDGIGLLQG Kraken2_NZ_CP051224.1 IMICODJL_47801 Prodigal:2.6 28579 29535 + VFG012504(gb|WP_000271276) 99.7 3.4099999999999996e-241 (iroE) esterase VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MYAREYRSTRPHKAIFFHLSCLTLICSAQVYAKPDMRPLGPNIADKGSVFYHFSVTSFDSVDGTRHYRVWTAVPNTTAPASGYPILYMLDGNAVMDRLDDELLKQLSEKTPPVIVAVGYQTNLPFDLNSRAYDYTPAAKSRKTDLHSGHFSRKSGGSNNFRQLLETRIAPKVEQGLNIDRQRRGLWGHSYGGLFVLDSWLSSSYFRSYYSASPSLGRGYDALLSRVTAVEPLQFCAKHLAIMEGSATQGDNRETHAVGVLSKIHTTLTILKDKGVNAVFWDFPNLGHGPMFNASFRQALLDISGENANYTAGCHELSH Kraken2_NZ_CP051224.1 IMICODJL_47802 Prodigal:2.6 29580 31757 - VFG012499(gb|WP_001222186) 100.0 0.0 (iroN) salmochelin receptor IroN VF0230 Salmochelin siderophore VFC0272 Nutritional/Metabolic factor Also identified as virulence factors in extracellular pathogenic Escherichia coli and Salmonella enterica serotype Typhi Catecholate siderophore receptor, mediates utilization of the siderophore enterobactin MRINKILWSLTVLLVGLNSQVSVAKSSDDDNDETLVVEATAEQVLKQQPGVSVITSEDIKKTPPVNDLSDIIRKMPGVNLTGNSASGTRGNNRQIDIRGMGPENTLILIDGVPVTSRNSVRYSWRGERDTRGDTNWVPPEQVERIEVIRGPAAARYGSGAAGGVVNIITKRPTNDWHGSLSLYTNQPESSDEGATRRANFSLSGPLAGNALTTRLYGNLNKTDADSWDINSPVGTKNAAGHEGVRNKDINGVVSWKLNPQQILDFEAGYSRQGNIYAGDTQNSSSSAVTESLAKSGKETNRLYRQNYGITHNGIWDWGQSRFGVYYEKTNNTRMNEGLSGGGEGRILAGEKFTTNRLSSWRTSGELNIPLNVMVDQTLTVGAEWNRDKLDDPSSTSLTVNDSDISGISGSAADRSSKNHSQISALYIEDNIEPVPGTNIIPGLRFDYLSDSGGNFSPSLNLSQELGDYFKVKAGVARTFKAPNLYQSSEGYLLYSKGNGCPKDITSGGCYLIGNKDLDPEISVNKEIGLEFTWEDYHASVTYFRNDYQNKIVAGDNVIGQTASGAYILKWQNGGKALVDGIEASMSFPLVKDRLNWNTNATWMITSEQKDTGNPLSVIPKYTINNSLNWTITQAFSASVNWTLYGRQKPRTHAETRSEDTGGLSGKELGAYSLVGTNFNYDINKNLRLNVGVSNILNKQIFRSSEGANTYNEPGRAYYAGVTASF Kraken2_NZ_CP051224.1 IMICODJL_47922 Prodigal:2.6 125527 127725 - VFG033944(gb|WP_000973519) 99.9 0.0 (iutA) ferric aerobactin receptor precusor IutA VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNIDHIEVISGATSLYGGGSTGGLINIVTKKGQPETMMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTERHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAVFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIAAGKATSADAIPGGSVDYDNFLFNAGLLMHITERQQAWLNFSQGVELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTVDLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF Kraken2_NZ_CP051224.1 IMICODJL_47923 Prodigal:2.6 127810 129087 - VFG033958(gb|WP_000750130) 100.0 0.0 (iucD) L-lysine 6-monooxygenase IucD VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MKKSVDFIGVGTGPFNLSIAALSHQIEELDCLFFDEHPHFSWHPGMLVPDCHMQTVFLKDLVSAVAPTNPYSFVNYLVKHKKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVENIDFDKKRRLFLVQTSQGEYFARNICLGTGKQPYLPPCVKHMTQSCFHASEMNLRRPDLSGKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISGFSGLEEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLESSGPGWKLLMEHHLDQGRESLESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDDFTLEWSGPKENNIFVVNASMQTHGIAEPQLSLMAWRSARILNRVMGRDLFDLSMPPALIQWRSGT Kraken2_NZ_CP051224.1 IMICODJL_47924 Prodigal:2.6 129084 130826 - VFG012522(gb|WP_001015721) 100.0 0.0 (iucC) aerobactin siderophore biosynthesis protein IucC VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MNHKDWDLVNRRLVAKMLSELEYEQVFHAESQGDDRYCINLPGAQWRFIAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKQVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLINLNADRLQCLLSGHPKFVFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMIWRCDNEMDIHQLLTAAMDPQEFARFSQVWQENGLDHNWLPLPVHPWQWQQKIATDFIADFAEGRMVSLGEFGDQWLAQQSLRTLTNASRRGGLDIKLPLTIYNTSCYRGIPGRYIAAGPLASRWLQQVFATDATLVQSGAVILGEPAAGYVSHEGYAALARAPYRYQEMLGVIWRENPCRWLKPDESPVLMATLMECDENNQPLAGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKEGVPQRVLLKDFQGDMRLVKEEFPEMDSLPQEVRDVTSRLSADYLIHDLQTGHFVTVLRFISPLMVRLGVPERRFYQLLAAVLSDYMKKHPQMSERFALFSLFRPQIIRVVLNPVKLTWPDLDGGSRMLPNYLEDLQNPLWLVTQEYES Kraken2_NZ_CP051224.1 IMICODJL_47925 Prodigal:2.6 130826 131773 - VFG033993(gb|WP_000011910) 100.0 1.2900000000000002e-248 (iucB) aerobactin siderophore biosynthesis protein IucB VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MSGANIVHSGYGLRCEKLDKPLNLGWGLDNSAVLHWPGELPTGWLCDALDQIFIAAPQLSAVVLPWSEWCEEPQALTLFGQVQSDIIHRSAFWQLPLWLSSPANRASGKMVFDAEREIYFPQRPPRPQGEVYRRYDPRIRRMLSFRIADPVSDAERFTRWMNDPRVEYFWEQSGSLEVQIAYLERQLTSKHAFPLIGCFDDRPFSYFEIYWAAEDRIGRHYSWQPFDRGLHLLVGEQQWRGAHYVQSWLRGVTHYLLLNEPRTQRTVLEPRTDNQRLFRHLEPAGYRTIKEFDFPHKRSRMVMADRHHFFTEVGL Kraken2_NZ_CP051224.1 IMICODJL_47926 Prodigal:2.6 131774 133498 - VFG012526(gb|WP_000602863) 100.0 0.0 (iucA) aerobactin siderophore biosynthesis protein IucD VF0229 Aerobactin VFC0272 Nutritional/Metabolic factor A hydroxamate siderophore expressed in many strains of E. coli, Shigella flexneri and Klebsiella pneumoniae; TonB-dependent iron transport 1,6-di(N6-acetyl-N6-hydroxylysine) citrate Iron uptake MILPSEKSATDVAAQCFLNALIRETKDWQLAEYPPDELIIPLDEQKSLHFRVAYFSPTQHHRFAFPAHLVTASGSYPVDFTTLSRLIIDKLRHQLFLPVPLCETFHQRVLESYAHTQQTIDARHDWAILREKALNFGEAEQALLTGHAFHPAPKSHEPFNRQEAERYLPDMAPHFPLRWFSVDKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLHPWQGEYLLQQVWCQALFAKGLIRDLGEAGTSWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVERGMRLARLAQTDGWQMLQARFPTFRVMQEDGWAGLRDLNGNIMQESLFSLRENLLLEQPQSQTNVLVSLTQAAPDGGDSLLVSAVKRLSDRLGITVQQAAHAWVDAYCQQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGFIYRDCQGSAFMPHATEWLDTIDEAQAENIFTREQLLRYFPYYLLVNSTFAVTAALGAAGLDSEANLMARVRTLLAEVRDQVTHKTCLNYVLESPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLQAQEV Kraken2_NZ_CP051224.1 IMICODJL_47931 Prodigal:2.6 136830 137687 - VFG012590(gb|WP_000968139) 100.0 1.78e-190 (sitD) iron/manganese ABC transporter permease subunit SitD VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MMALLLEPLQFTFMSHALLISLVVSIPCALLSVFLVLKSWALMGDAMSHAVFPGIVLAWILGLPLATGAFVAGVFCAVATGYLKDNSRIKQDTVMGIVFSGMFAAGLILYIAVKPDVHLDHILFGDMLGITIGDIIQTVIIAGLVTLVISVKWRDFLLFSFDYQQAQASGLHTRWLHYGLLCMVSLTIVATLKAVGIILSISLLIAPGAIAVLLTQRFHIALLLATGISILVSMTGVWLSFFIDSAPAPTIVVLFAVMFIMTFTVTSINARTKENAEPRDLLSSD Kraken2_NZ_CP051224.1 IMICODJL_47932 Prodigal:2.6 137684 138541 - VFG012585(gb|WP_001101723) 100.0 1.48e-198 (sitC) iron/manganese ABC transporter permease subunit SitC VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MNVLLEPFSYEYMLNAMWVSAMVGGLCAFLSCYLMLKGWSLIGDALSHSIVPGVAGAYMLGLPFSLGAFFSGGLAAGSMLFLNQLTRLKEDAIIGLIFSSFFGLGLFMVSLNPTSVNIQTIVLGNILAIDPADILQLTIIGILSIIVLFFKWKDLMVTFFDENHARAIGLHPGRLKILFFTLLSVSTVAALQTVGAFLVICLVVTPGATAWLLTDRFPRLLMIAVTIGSVTSFLGAWVSYFLDGATGGIIVVAQTLLFLLAFVFAPTHGLLANRRRAHKALEDRS Kraken2_NZ_CP051224.1 IMICODJL_47933 Prodigal:2.6 138538 139362 - VFG034214(gb|WP_000983710) 100.0 3.3500000000000003e-192 (sitB) iron/manganese ABC transporter ATP-binding protein SitB VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MQSAGIVVNDVTVTWRNGHTALRDASFTVPGGSIAALVGVNGSGKSTLFKAIMGFVRLTSGKISVLGIPTRQALQKNLVAYVPQSEEVDWSFPVLVEDVVMMGRYGHMGMLRIAKKRDRQIVTDALERVDMVDFRHRQIGELSGGQKKRVFLARAIAQQGDVILLDEPFTGVDVKTEAKIISLLRELRAEGKTMLVSTHNLGSVTTFCDYTVMVKGTVLASGPTDTTFTAENLELAFSGVLRHVTLNGSEESIITDDERPFVAHRPSAVQREER Kraken2_NZ_CP051224.1 IMICODJL_47934 Prodigal:2.6 139365 140279 - VFG012575(gb|WP_000949004) 100.0 4.37e-221 (sitA) iron/manganese ABC transporter substrate-binding protein SitA VF1116 Iron/manganese transport VFC0272 Nutritional/Metabolic factor MLSIKKVTMLLGCLVLTCSIAFQASAAEKFKVITTFTIIADMAKNVAGDAAEVSSITKPGAEIHEYQPTPGDIKRAQGAQLILANGMNLELWFQRFYQHLNGVPEVIVSSGVTPVGITEGPYEGKPNPHAWMSPDNALIYVDNIRDAFIKYDPANAQTYQRNADTYKAKITQTLAPLRKQIAELPENQRWMVTSEGAFSYLARDLGLKELYLWPINADQQGTPQQVRKVVDIVKKNHIPAVFSESTISDKPARQVARETGAHYGGVLYVDSLSTENGPVPTYIDLLKVTTSTLVQGIKAGKREK Kraken2_NZ_CP051225.1 IMICODJL_47951 Prodigal:2.6 7429 8385 + VFG045767(gb|WP_012979404) 63.0 8.1e-139 (lvhB11) P-type conjugative transfer ATPase TrbB VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MDTVDSVDLRAIEKLKRDMGRSLMEALEDPETLEIMLNPDGKLWREKFGQPMFCMGTVPVQRSKTIIQTIAGFHKKIIDSNSPFLECELPIDGSRFAGQLPPLVAGPTFAIRKKASRIFLLDEYVDKGVMTRVQADFICRAIAAHKNILVIGGTGSGKTTLLNAIIAEIVRQFPDERICIIEDTGELQCAALNFVQYHTTINVTMTDILRLILRMRPDRIFVGETRGPEALDMLDAWNTGHEGGAASLHANNTLSALTRLRSLISRNPFAPREIEPVIGEAVNVIVQISKTSEGRRIKEIREIQGYENGEYISQLIAA Kraken2_NZ_CP051225.1 IMICODJL_47954 Prodigal:2.6 9208 11751 + VFG045766(gb|WP_012979408) 63.0 0.0 (lvhB4) conjugal transfer protein TrbE VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MNTAIPVLVALIGLILLGMMLAYYQRMVKEYHLKKYRSKDESFADMLNYAAVVDDGVIVCKNGSFMASFFFKGADNASATDQERELVSFRINKAIGRLGNGWMMHVDAIRNPAPSYSDRNASHFPDRVSAAVDEERRRLFEKLGQLYEGCFIVTFTWFPPALAESKFTELMFDDERVVSTDKDTTLNLIEKFKHEISIIQANLSQAVSIERLNGVKIEQEDGSVATMDQQLEYLQYCITGLQHPIRLPNNPIYLDSLIGGQEFIPGITPRIGKNFIQVVAIEGYPSESYPGILSKLAEQPCEYRWSTRFIFLDSHEAISKLTAFRRKWKQKVRGFMSQLFNTNNGYVDEDALSMVNDASSAIAETNSGLVSQGYITSVIVLMNEDRQKVEDAAEFMRKAVNNTGFAARIETVNTVDAYFGSLPGHGVENVRRPLVNTLNLADLMPTSTIWPGENKAPSPLFEVGAPPLTHCVTSGNTPFRLNLHVRDLGHAFMFGPTRAGKSTHLALTAMQWRRYSNSRIFTFDKGLSMFATCKAVGGKHFTIAGDDNQLAFAPLSRLDTPTRRTWAMEWIEAILILNGVNVDAPMRNSIADAIKSMSETHSKTLSEFTVTVQNNVIREALKQYTIDGNMGHLLDAEEDGLDISDFMTFEIEHLMNMDQKYALPVLLYLFRRIEESLDGNPTLIILDEAWLMLGHPEFRGKIRDWLKSMAKKNCAVLMATQQLSDAANSGILDVIIESTASRFFLPNGNALQEEAMSLYINMGLNRRQIEIIASAVPKRDYYYVSEQGRRLYQLALGPLALAFVGATDPDSIATIKQLSETYGDGWVDEWLRTKGLDLNDYEYEVAA Kraken2_NZ_CP051225.1 IMICODJL_47976 Prodigal:2.6 30933 32876 - VFG045768(gb|WP_012979416) 65.6 1.7699999999999996e-298 (lvhD4) type IV secretory system conjugative DNA transfer family protein VF0799 Lvh (Legionella vir homologs) type IVA secretion system VFC0086 Effector delivery system MRKPNNAVGPQVRNKKKTARGKLIPAMAITSLAAGIQAATQYFAYSFNYQELLGPNFNHIYAPWSYFKWYSAWHERLPDAFFAAGSVGAAVAAGGLVLTALTSMMKANSSKANEYLHGSARWADEQDIRDAGLLNDEGVYVGAWEDKNGQLRYLRHNGPEHVLTYAPTRSGKGVGLVVPTLLSWKHSTVVADLKGELWAMTAGWRKEYAKNLCLKFEPAAANGSVAWNPLDEIRVGTENEVGDVQNLATLIVDPDGKGLNDHWQKTSQALLVGVILHVLYKHKNEGTPATLPYVDSIMADPERGAGELWMEMTQYSHINGENHPVVGAAGRDMMDRPEEEAGSVLSTAKSYLALFRDPVVARNVSESHFKIKDLMNHDDPVSLYIVTQPNDKARLRPLVRIMLNMIVRLLADKMEFERVDNNLTLWQRFKQAFGFSVQGTKRVQTKKTYKHRLLGMIDEFPSLGKLEIIQESLAFLAGYGIKFYLICQDINQLRSRETGYGPDETITSNCHVQNAYPPNRTETAEHLSKLTGQTTVIKEQITTSGKRASAILGGVSKTIQEVQRPLLTVDECLRMPGPKKNAEGLITERGDMVIYVAGFPAIYGKQPLFFQDEIFSLRASVPAPKVTDRIRAVAAANDDASNEAIAI Kraken2_NZ_CP050647.1 IMICODJL_48148 Prodigal:2.6 6368 8875 + VFG042515(gb|AAO73849) 62.3 0.0 (fotD) FotD VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MRLRKKLLLPSLLVFISNRAVGGDYFDPSLLAAGIDGENIDLSVFSHPGGGIEGEQEVSVQVNDNFYTRKTLHFRNSGDKGLLPDFPAGFFDDLLAPEYRPVQKDALLSSADFMSRTPYSSVTFNQGEGRVDIRVPQAFLGRAAQLRSSPDTWENGVPALLMDYSLTGNRNDSDSYSSRSLYASARLGLNVGPWRLRTSGNYSQYQSESRWSHSRTENSSFYSTWLERDISALRASLRIGEVSTGGMILDSVSFRGVRLYSNDDMLSSRLRNYSPTVKGFARTQAVVIITQNGRQVYQTNVPAGPFELNDFYISGYSGDLVVTVRESDGSEHSFIQPFSTLPEMKREGVSGFELSAGRYDNHGSEDYYNDPLFVYGAWSRGFGGGVTVFGETLQAGKYQSAGIGSTLSLGRVGAVSADISVSRAEKYDDIHTGQSYGLKYSKSQVETGTTVTLATYRYSTKDFYSFGDFVSRTEQARYVWENRLKNRMTLSLNQSLGSLGSVSLSASQQDYWTSGEVNRSFSLSHSFSWRDIYFSTTFSMDQMSGNRYGYDNNRQIDFYMSVPLSRLLGREEPTSSSVSWSATRTERQLRQTATLSGSVPDTRMRYRVGGNWGNGGAAEGQSASLTWNGDFTTASLGYTRSGGYRTTDFSLSGAAVAWSGGVAFGSNSVTDNGAIVVNTSGVSGIGTSAGGRTTWPGTALISSPQLYTENRIDLRTDGLPDDIVLAETSARTVPSRGAVVVLDYTVYRGGQVVFTLKRPDGSALPFGSVVSLDGMPSGKENTGIVGDEGRVYLAGVPEKGRLTVNSGGKQCHADFVLPQDRKKSGPVAEAVAVCR Kraken2_NZ_CP050647.1 IMICODJL_48155 Prodigal:2.6 13867 14625 + VFG033071(gb|WP_001815900) 86.5 3.28e-165 (paa) outer membrane adhesin Paa VF0194 Paa Porcine attaching-effacing associated protein VFC0001 Adherence Paa sequences are often present in A/E strains, especially O157:H7 strains. The predicted amino acid sequence of Paa is identical to those of the Paa proteins of O157:H7 strains EDL933 and Sakai, and very similar to AcfC of V. cholerae; paa gene is absent in nonpathogenic E. coli, and the G+C content of paa (44%) differs from that of E. coli K-12 (50.8%) Involved in the initial bacterial adherence, required for the A/E activity MKKKLISTFIFLSSTAYADIHLYGPGGPHTALLDAARLYSEKTGVTVNVHYGPQHKWNEEARKNADILFGASEQSALAIIRDHKERFSEKDIQPIYLRKSILLVKKGNPKNIRSIDDLTKTGIGIIVNDGGGTSNTSGTGVWEDIAGRKGNIETVAAIRKNIILYAPNSGTARNALENQPDADVWITWADWAASNPGIGDVVEIAPDYVIWRDMNIAIRHDADAETRQFAAWLQTDEAAPAFKKYGWTKKGT Kraken2_NZ_CP050647.1 IMICODJL_48171 Prodigal:2.6 25570 26073 + VFG042510(gb|AAO73844) 64.2 6.05e-41 (fotS) FotS VF0213 Adhesive fimbriae VFC0001 Adherence Adherence is mediated by proteinaceous surface structures that are referred to as colonization factors (CFs), colonization factor antigens (CFAs), coli surface antigens (CSAs), or putative colonization factors (PCFs); ETEC strains are host-specific. The CFs confer host specificity on the strain. In human-specific ETEC strains, 21 different CFs have been identified. Approximately 75% of human ETEC express either CFA/I, CFA/II or CFA/IV. Animal-specific ETEC strains produce a variety of CFs that are distinct from those produced by human-specific isolates, such as K88 and K99; ETEC strains typically possess multiple plasmids with a wide range of molecular masses. The genes encoding CFs generally are found on a plasmid that also encodes ST and/or LT ETEC CFs can be classified as fimbriae or fibrillae depending on their structure. The fimbrial CFs are rigid filamentous, rodlike structures, whereas the fibrillar CFs are thinner, more flexible, and have fewer subunits in each helical turn than do fimbrial CFs Adhesin, receptor is the oligosaccharide components of glycolipids and glycoproteins MRLRSPSADSPWFFPSRNGTHITRQRFWQIIRAYAVMDGLAVSVHPHMLRHACGFALAERGNDTRLIQDYLGHKNIRHTVRYTATSPARFRQAWIHPHCHTLSPDNTPPEHDVMHTEYHIRSSSAHFLPPHLSVIHHEYGNMIKNICRELDNIQHILKRMDAQATAE Kraken2_NZ_CP050647.1 IMICODJL_48179 Prodigal:2.6 33677 37174 + VFG036043(gb|WP_001038844) 97.8 0.0 (aatA) autotransporter outer membrane beta-barrel domain-containing protein VF1133 AatA, AIDA-I type VFC0001 Adherence MNKNLRILQFLVSILYSVQSHFSGAQTIQLNGNGIPESITRSITGVDGNEALNISVPYKTSYTQNILSVESSINIKGGTSNTSIGGAGVYGENFTLNNNGSVWGGDGYNGGVAVSGNKISINNYRNVYGGNGLGGSGSSGGAGLSGDDIIVDNYRSIYGGDDLGGTGGSGVTGSNITVHNSGGIWGGNGVNGGDGINGSNLFITNDNMISGGYGIKQGGDAISGNQITLNNNGIVQGGYGPDGGCSVYGEDIHINNHGDLSGSYNSQRDAYNTSIIFSGGYNSLDIYSDSVINGDIKLASIPVNGTNELIIKNINNATAINGGLMIGNGSSVYLSGKNSIFNGNISVDEDASMNLSAGNANVHANTITLKSDSWLNIDTSIKNWTQDYYTLLSSDTGISIADNSHIVQYNVLLTEGAESYVYTSLNDDDNKLISMLRWNNTKGMGYGTFNIEKDATLNIGVSLSDNLSPLLYDGWDGKSLTKSGNGTLILSATNNYTGNTEVKSGVLILAAPDALGRTEYLYLSRGAELDMNGYPQTISKLLTAAGSVLNIHGGSLILNNGGESAGTIAGDGSLNINGGMLDITGNNRNFSGVFTVNKGAQLAVSTADNLGTAFVDNYGTLTLNSTSAWQLTNNISGYGNVRKTGAGALNISDNAKWTGMTDIIQGTLILGNADSPVMLGSNQVIVEEQGKLSGFGGVAGNLSNSGIVDLTTYMPGNILTVGGNYTGRNGLILLQTETGGDNSKTDRLVIKGNASGRTRVAVTQAGGTGAETLNGIEVIHVSGNADNAEFIQTERITAGAYDYILKRGQGINSTNWYLISRKDIPVPQPEAVPENHDNNLRPEAGSYVASIAAANNLFVTNLYERQGQELYISHMTGEENEAGIWMYNKGKHNRWRDNSSQLRTRGNSYVVLIGGDIAQWSLNGTDRWHTGMMAGYGHNNNSTNALSTGYHSEGRMNGYTAGLYATWYANDETHNGSYLDSWLQYSWFDNHINGERLPAESWKSKGFTVSLEAGYSWKAGEFTDNYKGSHEWYVQPQLQVVRMNVKSDKYHESNGTSIENTGNGNILTRLGARTWLTSKNGKNTRYAVPFRPFVEAHWLHNSRVFGTSMNGVSIYQDGARDIGEINGGVAGMITPEVAFRADAGIQLGEHGYHNTSAMLSVEYRF Kraken2_NZ_CP050647.1 IMICODJL_48252 Prodigal:2.6 94396 95931 - VFG044067(gb|WP_001283335) 98.8 0.0 (ECS88_RS00560) colicin-like pore-forming protein VF1183 Colicin Ia VFC0235 Exotoxin MKTLRAGNADAADITRQEFRLLQAELREYGFRTEIAGYDALRLHTESRMLFADADSLRISPREARSLIEQAEKRQKDAQNTDKKAADMLAEYERRKGILDTRLSELEKNGGAALAILDAQQARLLGQQTRNDRAISEARNKLSLVTESLNTARNALTRAEQQLTQQKNTPDGKTIVSPEKFPGRSSTNHSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLTHSGLDYKRNILNDRNPVVTEDVEGDKKIYNAEVAEWDKLRQRLLDARNKITSAESAVNSARNNLSARTNEQKHANDALNALLKEKENIRNQLAGINQKIAEEKRKQDELKATKDAINFTTEFLKSVSEKYGAKAEQLAREMAGQAKGKKIRNVEEALKTYEKYRADINKKINAKDRAAIAAALESVKLSDISSNLNRFSRGLGYAGKFTSLADWITEFGKAVRTENWRPLFVKTEAIIAGNAATALVALVFSILTGSALGIIGYGLLMAVTGALIDESLVEKANKFWGI Kraken2_NZ_CP050647.1 IMICODJL_48264 Prodigal:2.6 101741 102472 - VFG042586(gb|WP_000916502) 93.4 7.820000000000001e-164 (HKK20_RS00080) fimbria/pilus periplasmic chaperone VF1149 Sfp fimbriae VFC0001 Adherence MQKMKPALKKTLMAVACLSAVPVAQAAVSLDRTRAIFNGDEKSMTLNIANDNKQLPYLAQAWVENEKKEKITTGPILATPPVQRLEPGSKSMVRLTSTPDISRLPQDRESLFYFSLREIPPKSDKANVLQIALQTKIKLFYRPESIKAQPNAVWQDQLVLNKTGGGYQIDNPTPYFVTVIGIGGSEKQAREGEFDAVMLAPKSTQMVKSGTYSTPYLSYINDYGGRPVLQFSCAGSRCTAVKK Kraken2_NZ_CP050647.1 IMICODJL_48265 Prodigal:2.6 102541 105051 - VFG042653(gb|CAC85335) 95.7 0.0 (pixC) PixC protein VF1151 Pix pilus VFC0001 Adherence MKKNKSTFTINFITYSLMLSLAGVPVYAVDFNTDVLDAADRQNIDFSRFSRAGYIMPGQYQMEIRVNGQDISPSAFQIAFLEPPFSDSDNEKPLPEPCLTPEIVSRMGLTEASQEKVTYWNNGQCADFRQLSGVEIRPNPAEGMLYINMPQAWLEYSDASWLPPSRWDNGIPGLLFDYNINGTVNKPHQGKQSQSLNYNGTAGANFGAWRLRADYQGNLNHTTGSAQGTDSQFTWSRFYMYRAIPRWRANLTLGENYINSEIFSSWRYTGASLESDDRMLPPKLRGYAPQVSGIADTNARVVISQQGRILYDATVPAGPFTIQDLDSSVRGRLDVEVIEQDGRKKTFQVDTAYVPYLTRPGQVRYRLVSGRSRNYEHTTEGPVFAAGEASWGISNKWSLYGGGIVAGDYNALAVGLGRDLNEFGTVSADVTQSVARIPGEETKQGKSWRLSYSKRFDDVNTDITFAGYRFSERNYMTMDQYLNARYRNDFTGREKELYTVTLNKNFEDWKASVNLQYSHQTYWDRRTSDYYTLSVNRYFDAFSFKNIALGISASRSKYQNRDNDSAFVRLSVPWGTGTASYSGSMSNDRYTNTVGYSDTLNNGLSSYSLNAGVNSGGGQPSQRQMSAYYNHNGSLTNLSASFSAVENGYSSFGMSASGGATVTMKGAALHAGGMNGGTRLLVDTDGVGGVPVDGGRVYTNRWGIGVVTDVSSYYRNTTSVDLNRLPEDMEAPRSVVESVLTEGAIGYREFEVLKGSRLFAVLRMSDNSYPPFGASVTNAKGRELGMVADSGLAWLSGVNPGETLNVGWDGRTQCVVDIPAHPDPAQQLLLPCRQVK Kraken2_NZ_CP050647.1 IMICODJL_48266 Prodigal:2.6 105172 105759 - VFG042652(gb|CAC85334) 90.6 4.31e-128 (pixH) PixH protein VF1151 Pix pilus VFC0001 Adherence MFWRMIISVPFFWCAMAQALPSASFPPPGMTLPEYWGEEHVWWDGRASFKGQVIAPACTLAMEDAWQEIDMGTTPLRDLQNSPAGPEKKFRLRLRNCELAGAGKLVYTATRVRVTFDGIPGETPDKFSLTGQAEGINLQIMDNYGYPVRAGKSMPPLILRGNEDGLDYTLRIVRNGYPLKAGDYYAALRFKLDYE Kraken2_NZ_CP050647.1 IMICODJL_48267 Prodigal:2.6 105835 106362 - VFG042583(gb|WP_000751015) 72.0 1.73e-83 (HKK20_RS00065) type 1 fimbrial protein VF1149 Sfp fimbriae VFC0001 Adherence MNKVIIATMLASTVSFGVNAANQGQGVINFKGTVIDAPCGIAQESADQTINFGQISKTHLNADGISVKKDLDIKLVNCDATEIGKLTNGVKVSFTGTTINGQNQELGTTGDTGTAIVVSAANGSLVSFDGTADSATKVKEGDNTLRYSTWVKKATGGTLKEGDFTAVANFNLAYE Kraken2_NZ_CP053560.1 IMICODJL_48292 Prodigal:2.6 21092 22972 + VFG043980(gb|WP_001283355) 95.8 0.0 (HS453_RS00480) colicin-like pore-forming protein VF1184 Colicin Ib VFC0235 Exotoxin MSDPVRITNPGAESLGYDSDGHEIMAVDIYVNPPRVDVFHGTPPAWSSFGNKTIWGGNEWVDDSPTRSDIEKRDKEITAYKNTLSAQQKENENKRTEAGKRLSAAIAAREKDENTLKTLRAGNADAADITRQEFRLLQAELREYGFRTEIAGYDALRLHTESRMLFADADSLRISPREARSLIEQAEKRQKDAQNADKKAADMLAEYERRKGILDTRLSELEKNGGAALAVLDAQQARLLGQQTRNDRAISEARNKLSSVTESLKTARNALTRAEQQLTQQKNTPDGKTIVSPEKFPGRSSTNHSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLTHSGLDYKRNILNDRNPVVTEDVEGDKKIYNAEVAEWDKLRQRLLDARNKITSAESAINSARNNVSARTNEQKHANDALNALLKEKENIRSQLADINQKIAEEKRKRDEINMVKDAIKLTSDFYRTIYDEFGKQASELAKELASVSQGKQIKSVDDALNAFDKFRNNLNKKYNIQDRMAISKALEAINQVHMAENFKLFSKAFGFTGKVIDRYDVAVELQKAVKTDNWRPFFVKLESLAAGRAASAVTAWAFSVMLGTPVGILGFAIIMAAVSALVNDKFIEQVNKLIGI Kraken2_NZ_CP053560.1 IMICODJL_48381 Prodigal:2.6 99683 100243 - VFG042890(gb|WP_000334696) 64.3 3.1199999999999996e-69 (STY_RS21730) lytic transglycosylase domain-containing protein VF0966 Type IV pili VFC0001 Adherence MSGGTVPLRLISLILLFSLIPPARASYVAPKQIWTNKWDNCFAAAGARYQIEPLLLKAISAGESSLRPGAININKDKKTGKASSTDYGLMQINSTHIPKLINMGVIKKSEDLITKPCLNIHIGSWILARHFQICGVSWNCLGSYNAGFRKDRHETREQYANKIWRIYRDMKGICLPGQGGRQCRQS Kraken2_NZ_CP053081.1 IMICODJL_48410 Prodigal:2.6 10833 12713 + VFG043980(gb|WP_001283355) 95.8 0.0 (HS453_RS00480) colicin-like pore-forming protein VF1184 Colicin Ib VFC0235 Exotoxin MSDPVRITNPGAESLGYDSDGHEIMAVDIYVNPPRVDVFHGTPPAWSSFGNKTIWGGNEWVDDSPTRSDIEKRDKEITAYKNTLSAQQKENENKRTEAGKRLSAAIAAREKDENTLKTLRAGNADAADITRQEFRLLQAELREYGFRTEIAGYDALRLHTESRMLFADADSLRISPREARSLIEQAEKRQKDAQNADKKAADMLAEYERRKGILDTRLSELEKNGGAALAVLDAQQARLLGQQTRNDRAISEARNKLSSVTESLKTARNALTRAEQQLTQQKNTPDGKTIVSPEKFPGRSSTNHSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLTHSGLDYKRNILNDRNPVVTEDVEGDKKIYNAEVAEWDKLRQRLLDARNKITSAESAINSARNNVSARTNEQKHANDALNALLKEKENIRSQLADINQKIAEEKRKRDEINMVKDAIKLTSDFYRTIYDEFGKQASELAKELASVSQGKQIKSVDDALNAFDKFRNNLNKKYNIQDRMAISKALEAINQVHMAENFKLFSKAFGFTGKVIDRYDVAVELQKAVKTDNWRPFFVKLESLAAGRAASAVTAWAFSVMLGTPVGILGFAIIMAAVSALVNDKFIEQVNKLIGI Kraken2_NZ_CP053081.1 IMICODJL_48504 Prodigal:2.6 89354 89914 - VFG042890(gb|WP_000334696) 64.3 3.1199999999999996e-69 (STY_RS21730) lytic transglycosylase domain-containing protein VF0966 Type IV pili VFC0001 Adherence MSGGTVPLRLISLILLFSLIPPARASYVAPKQIWTNKWDNCFAAAGARYQIEPLLLKAISAGESSLRPGAININKDKKTGKASSTDYGLMQINSTHIPKLINMGVIKKSEDLITKPCLNIHIGSWILARHFQICGVSWNCLGSYNAGFRKDRHETREQYANKIWRIYRDMKGICLPGQGGRQCRQS Kraken2_NZ_CP053082.1 IMICODJL_48573 Prodigal:2.6 34245 34931 + VFG001445(gb|AAA92657) 99.0 1.06e-145 (AAA92657) unknown protein VF0241 TraJ VFC0083 Invasion Belongs to a cluster of genes within the F-like plasmid R1-19 transfer region called the tra operon; homology with a component of the bacterial conjugation system Contributes to the ability of E. coli K1 to invade the central nervous system and cause meningitis in the neonatal rat; TraJ contributes to the early systemic dissemination of E. coli K1 in the oral infection process is via specific TraJ-dependent bacterial interactions with macrophages. TraJ enables the bacteria to be taken up efficiently by macrophages. In the early steps of dissemination, the intracellular environment of the phagocytes provides a protective or safe site from the initial host inflammatory defense mechanisms MCALDRRERPLNSQSVNKYILNVQNIYRNSPVPVCVRNKNRKILYANGAFIELFSREDKPLSGESYIRLQVEIFLSSLELECQALGHGSAFCRRFNFHGEIYQIRMENVSFYNDESVVLWQINPFPDYPFFALSQSGSNTNTSDKLTIWNDLSPGTLLVFSFYMLGVGHATIARELGITDRASEDRIKPVKRKIKEFFEHFDLFRVSCIYKGKIDLLLNIIREFYSVK Kraken2_NZ_CP053679.1 IMICODJL_48727 Prodigal:2.6 21092 22972 + VFG043980(gb|WP_001283355) 95.8 0.0 (HS453_RS00480) colicin-like pore-forming protein VF1184 Colicin Ib VFC0235 Exotoxin MSDPVRITNPGAESLGYDSDGHEIMAVDIYVNPPRVDVFHGTPPAWSSFGNKTIWGGNEWVDDSPTRSDIEKRDKEITAYKNTLSAQQKENENKRTEAGKRLSAAIAAREKDENTLKTLRAGNADAADITRQEFRLLQAELREYGFRTEIAGYDALRLHTESRMLFADADSLRISPREARSLIEQAEKRQKDAQNADKKAADMLAEYERRKGILDTRLSELEKNGGAALAVLDAQQARLLGQQTRNDRAISEARNKLSSVTESLKTARNALTRAEQQLTQQKNTPDGKTIVSPEKFPGRSSTNHSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLTHSGLDYKRNILNDRNPVVTEDVEGDKKIYNAEVAEWDKLRQRLLDARNKITSAESAINSARNNVSARTNEQKHANDALNALLKEKENIRSQLADINQKIAEEKRKRDEINMVKDAIKLTSDFYRTIYDEFGKQASELAKELASVSQGKQIKSVDDALNAFDKFRNNLNKKYNIQDRMAISKALEAINQVHMAENFKLFSKAFGFTGKVIDRYDVAVELQKAVKTDNWRPFFVKLESLAAGRAASAVTAWAFSVMLGTPVGILGFAIIMAAVSALVNDKFIEQVNKLIGI Kraken2_NZ_CP053679.1 IMICODJL_48816 Prodigal:2.6 99683 100243 - VFG042890(gb|WP_000334696) 64.3 3.1199999999999996e-69 (STY_RS21730) lytic transglycosylase domain-containing protein VF0966 Type IV pili VFC0001 Adherence MSGGTVPLRLISLILLFSLIPPARASYVAPKQIWTNKWDNCFAAAGARYQIEPLLLKAISAGESSLRPGAININKDKKTGKASSTDYGLMQINSTHIPKLINMGVIKKSEDLITKPCLNIHIGSWILARHFQICGVSWNCLGSYNAGFRKDRHETREQYANKIWRIYRDMKGICLPGQGGRQCRQS Kraken2_NZ_CP053678.1 IMICODJL_48854 Prodigal:2.6 18204 20084 + VFG043980(gb|WP_001283355) 95.8 0.0 (HS453_RS00480) colicin-like pore-forming protein VF1184 Colicin Ib VFC0235 Exotoxin MSDPVRITNPGAESLGYDSDGHEIMAVDIYVNPPRVDVFHGTPPAWSSFGNKTIWGGNEWVDDSPTRSDIEKRDKEITAYKNTLSAQQKENENKRTEAGKRLSAAIAAREKDENTLKTLRAGNADAADITRQEFRLLQAELREYGFRTEIAGYDALRLHTESRMLFADADSLRISPREARSLIEQAEKRQKDAQNADKKAADMLAEYERRKGILDTRLSELEKNGGAALAVLDAQQARLLGQQTRNDRAISEARNKLSSVTESLKTARNALTRAEQQLTQQKNTPDGKTIVSPEKFPGRSSTNHSIVVSGDPRFAGTIKITTSAVIDNRANLNYLLTHSGLDYKRNILNDRNPVVTEDVEGDKKIYNAEVAEWDKLRQRLLDARNKITSAESAINSARNNVSARTNEQKHANDALNALLKEKENIRSQLADINQKIAEEKRKRDEINMVKDAIKLTSDFYRTIYDEFGKQASELAKELASVSQGKQIKSVDDALNAFDKFRNNLNKKYNIQDRMAISKALEAINQVHMAENFKLFSKAFGFTGKVIDRYDVAVELQKAVKTDNWRPFFVKLESLAAGRAASAVTAWAFSVMLGTPVGILGFAIIMAAVSALVNDKFIEQVNKLIGI Kraken2_NZ_CP053678.1 IMICODJL_48947 Prodigal:2.6 99428 99988 - VFG042890(gb|WP_000334696) 64.3 3.1199999999999996e-69 (STY_RS21730) lytic transglycosylase domain-containing protein VF0966 Type IV pili VFC0001 Adherence MSGGTVPLRLISLILLFSLIPPARASYVAPKQIWTNKWDNCFAAAGARYQIEPLLLKAISAGESSLRPGAININKDKKTGKASSTDYGLMQINSTHIPKLINMGVIKKSEDLITKPCLNIHIGSWILARHFQICGVSWNCLGSYNAGFRKDRHETREQYANKIWRIYRDMKGICLPGQGGRQCRQS Kraken2_NZ_CP040851.1 IMICODJL_49295 Prodigal:2.6 237 908 - VFG042989(gb|ACI49672) 98.7 2.11e-158 (ACI49672) putative housekeeping sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKKWLFGFLGVALIVVCSVFGYVSYQKHEGEVFKQNIEKKMPVDQINAHAKSYKEDATNVNNDMSLGQMLSIQKEAIEMGVNKQVFAQIQIPALGLALPIFKGANQYTLSLGAATYFYEDAEMGKGNYVLAGHNMEMPGVLFSDIQKLSLGEVMDLVSNDGVYRYKVTRKFIVPGYFRLIDGVPEENSFLSLPKKGEKPLLTLFTCVYTSQGKERYVVQGELQ Kraken2_NZ_CP040851.1 IMICODJL_49356 Prodigal:2.6 57940 60030 - VFG042984(gb|ACI49668) 98.1 0.0 (ACI49668) minor pilin subunit VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MNFKHSWTRRLKYVFPIMMMLGTLFGLKTANVFAEKVIVDPSNPIQNVKNNFIIPKDVPNAKTNITVNGASKVYKYHVDANKGGFTDDYVGLVEGNKNIRYPSFQKEYGETNLVLEGVTTNTKVNIDYGKIGTYNGKKVNIKLVLSNIHLYSDTLPWNLLDNNYTKTHFRDDGYKNTNGAMSKSKKRTVLWISDNLFSGIVYHSTQMNVQLVATYEDGSPVQFSGDTFISFNSLNPAGGKSTDLKGEYAHYDKMNTTDWYVRQDAVLSEFKSFYNNLNVVGGHPGGSSKLTQADNDFNNLHDKLGDPKFGQGTVSFKISEANPTFVIGSSNVQTWFTLSSATIFSVVPDQPEKTGVDKNGNNVNDKMLQVGDTIQYRIKQKVNRLGVDLLAVYDRFELIDNLPKEVDYVDAHVESGTNKKFDVSGEVTYDKTKHQVKYAAKADTLKNRMKYNGETYELVINVKVNELANQNSVAKNQGTSIINKVEKDTNIITVYFPKIPVKEVQQNGKDVNGRNDGKKGTPTAPLNAGSEVQYLVTQKWHTKGVDAASDHYKQFSIQDPIEARLTYNDGSAQVIDKSTGKDITSEGTLTYDSNSRTLKWEASADFLNNNLLDGREIQLIFTAKTPLQSEKNIDNQAVVAVDNVSNKTNVVTIGVDPNLPQVIVPKTGSTHLVTILAVSLLLLVLATFGYAVLKFN Kraken2_NZ_CP040851.1 IMICODJL_49357 Prodigal:2.6 60027 60287 - VFG042985(gb|ACI49669) 98.8 2.15e-49 (ACI49669) hypothetical hydrophobic peptide VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKLIKLLLFNLSCLTAVFLYCGLLFSQLSILPSYQLYLMRILNIPAASMPLDIMEKLIRNPLFTTINLIVIVGISLVIYKKEGMKG Kraken2_NZ_CP040851.1 IMICODJL_49358 Prodigal:2.6 60300 61061 - VFG042986(gb|ACI49673) 94.1 2.42e-151 (ACI49673) cell wall-associated LPXTG-like protein VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MRNRKWLFVCAAALFSFTAYTQLTFADSQESTDSTEQTIQTSDSSTIQSSDETVDSSTVDSSEEPKIAEDDQIVKQTIHVQKIISSEQLDNQGQKLEKQEGVNGAKFSVYDVSDILQKMDVKNLTTDQIESQLKDRVKKLSGDQLKLVSNGETKTIDQQTGVFEFSIEVQANQKQAYYIVNESSPENISNSEDILLLTPVSEKNGEFLKDVWIYPKSEASQPKEEVKKIVSTGVKKNFFENCWDFVTHLFSRD Kraken2_NZ_CP040851.1 IMICODJL_49359 Prodigal:2.6 61077 61829 - VFG042987(gb|ACI49670) 98.8 1.8e-177 (ACI49670) putative pilus-dedicated sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MIIRHPKKKRIMGKWIIAFWLLSAVGVLLLMPAEASVAKYQQNQQIAAIDRTGTAAETDSSLDVSKIELGDPVGILTIPSISLKLPIYDGTSDKILENGVGITEGTGDITGGNGKNPLIAGHSGLYKDNLFDDLPSVKKGEKFYIKVDGEQHAYQIDRIEEVQKDELQRNFVTYLEPNPNEDRVTLMTCTPKGINTHRFLVYGKRVTFTKSELKDEENKKQKLSWKWLLGSTVFLSVMIIGSLFVYKKKK Kraken2_NZ_CP040851.1 IMICODJL_49360 Prodigal:2.6 61842 63467 - VFG042988(gb|ACI49671) 94.5 0.0 (pilA) PilA VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKDVEDKGSNSEYVKNATNKITSAVDENGEITFADQPSYVNSKGNVYVIYESKSAAGLVTQKAKPMVVIAPMTDNTGSGFLKDIHLYPKNIVSKLSFELTKFGDDGTEQSKQTPLKGAKFELYKGEPGKGSKLGDLVSDDQGKLTATDLTLGKYYFVEVPSEVVVGSDKEPTADQYLLGADARNDAHNKLTFEITNDGVTSDLKASYVNYKAPVIDKTVTNGTGDEHSFQVGDAVNYQGTIHIPTDIAGGTDGITVNGVKSETSPYSMFKWGDTAGKGLSYVAEKADIKVTNNDGSVVLKENTDYKIENSDSGFVIDFIVNNGQVSDTVANLHGQDLKMTYNMFVNESAEIANPLTNSVDFVYNNNPFNQEEHHEKSKADVVTYGAKFLKVDSGLFGTGIKATPLEGAEFAAKNAEGKYYGGLTDTDKDGVKEAVWVDDVANAAILKSDKEGHFEITGLTEGDYSLEETKAPENYQKLTKEISFKVDKDSYKEENRITIKNNQKASVPMTGSNGFQSYVLISCLLLGAGAISAVVYFKKKA Kraken2_NZ_CP040897.1 IMICODJL_49413 Prodigal:2.6 44259 48185 + VFG002164(gb|WP_002395058) 95.4 0.0 (prgB/asc10) aggregation substance PrgB/Asc10 VF0352 AS Aggregation substance VFC0001 Adherence AS is the common designation for a group of proteins that are encoded on pheromone-inducible conjugative plasmids and that are highly similar at the amino acid level.; pheromone responsive bacterial adhesin that mediates efficient contact between donor and recipient bacterium, facilitating plasmid conjugation; AS is expressed by the donor cell, the bacterial conjugation process requires the 'binding substances' (BS) be expressed on the surface of the recipient cell Proteinaceous, hair-like structure on the cell surface Contributes to pathogenicity by enhancing cell adhesion to cultured renal tubular cells and intestinal epithelial cells and may involve in internalization into enterocytes; promoting direct, opsonin-independent binding of E. faecalis to human neutrophils via a complement receptor-mediated mechanism, and thus protecting E. faecalis from killing the polymorphonuclear leukocytes, an important urinary tract defense element. But AS has not been directly assessed as a urovirulence factor. A role in urovirulence has been directly demonstrated only for Esp;Asc10 and Asa1 have been implicated in binding to components of the extracellular matrix such as fibrin, fibronectin, thrombospondin, vitronectin and collagen type I. MKQQTEVKKRFKTYKAKKRWVTAPILFIGVLGVVGLATDNVQAAELDSQPGTTTVQPDNPDLQSGKETPKTAVSEEAALQKDTTSQPTKVEEVAPENKGTEQSSATPNDTINAQQPTAEAEKSAQEQPVVSPETANEPLGQPTEVAPAENEANKSTIIPKEFETPDVDKAVDEAKKDPNITVVEKPAEDLGNVSSKDLAAKEKEVDKLQKEQAKKIAQQAAELKAKNEKIAKENAEIAAKNKAEKERYEKEVAEYNKHKNENSYVNEAISKNLVFDQSVVTKDTKISSIKGGKFIKATDFNKVNAGDSKDIFTKLRKDMGGKATGNFQNSFVKEANLGSNGGYAVLLEKNKPVTVTYTGLNASYLGRKITKAEFVYELQSSPSQSGTLNAVFSNDPIITAFIGTNRVNGKDVKTRLTIKFFDASGKEVLPDKASPFAYALSSLNSSLTNKGGHAEFVSDFGANNAFKYINGSYVKKQADGKFYSPEDIDYGTGPSGLKNSDWDAVGHKNAYFGSGVGLANGRISFSFGMTTKGKSNVPVSSAQWFAFSTNLNAKSVTPKRQFNSPKEPEKATIEFNRYKANVVPVLVPNKEVTDGQKNINDLNLKRGDSLQYIVTGDTTELAKVDPKTVTKQGIRDTFDAEKVTIDLSKVKVYQADASLNEKDLKAVAAAINSGKAKDVTASYDLHLDQNTVTAMMKTNADGSVVLAMGYKYLLVLPFVVKNVEGDFENTAVQLTNDGETVTNTVINHVPRSNPSKDVKADKNGTVGSVSLHDKDIPLQTKIYYEVKSSERPANYGGITEEWGMNDVLDTTHDRFTGKWHAITNYDLKVGDKTLKAGTDISAYILLENKDNKDLTFTMNQALLAALNEGSNKVGKQAWSVYLEVQRIKTGDVENTQTENYNKELVRSNTVVTHTPDDPKPTKAVHNKKGEDINHGKVARGDVLSYEMTWDLKGYDKDFAFDTVDLATGVSFFDDYDETKVSPIKDLLRVKDSKGVDITNQFTISWDDAKGTVTISAKDPQAFILAYGGQELRVTLPTKVKANVSGDVYNSAEQNTFGQRIKTNTVVNHIPKVNPKKDVVIKVGDKQSQNGATIKLGEKFFYEFTSSDIPAEYAGVVEEWSINDKLDVKHDKFSGQWSVFANSAFVLADGTKVNKGDDISKLFTMTFDKGVVKITASQAFLDAMNLKENKHVAHSWKAFIGVERIAAGDVYNTIEESFNNEKIKTNTVVTHTPEKPQTPQTPPEKTVIVPPTPKTPQAPVEPLVVEKASIVPELPKTGEKQNVLLTVAGSLAALLGLAGLGFKRRKETK Kraken2_NZ_CP040873.1 IMICODJL_49492 Prodigal:2.6 44499 45170 + VFG042989(gb|ACI49672) 99.1 1.27e-159 (ACI49672) putative housekeeping sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKKWLFGFLGVALIVFCSVFGYVSYQKHEGEVFKQNIEKKMPVDQINAHAKSYKEDATNVNNDMSLGQMLSIQKEAIKMGVNKQVFAQIQIPALGLALPIFKGANQYTLSLGAATYFYEDAKMGKGNYVLAGHNMEMPGVLFSDIQKLSLGEVMDLVSNDGVYRYKVTRKFIVPEYFKLIDGVPEENSFLSLPKKGEKPLLTLFTCVYTSQGKERYVVQGELQ Kraken2_NZ_CP040873.1 IMICODJL_49493 Prodigal:2.6 45223 47199 + VFG042988(gb|ACI49671) 98.6 0.0 (pilA) PilA VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MAINRYVKKAGMLVGMLGIIASCFQGYQAYAEDVTQKTPPEKVNITVHKLMYDQGTQLNVDIDGIKNDGYTHDQYPTGVTKYNKADYGDVEFTLGNITNQVLPTEDSDLTNAKVDEIVKDVEDKGSNSEYVKNATNKITSAVDENGVITFADQPAYVNSKGNVYVVYESKSAAGLVTQKAKPMVVIAPMTDNTGSGFLKDIHLYPKNIVSKLSFELTKFGDDGTAQSKQTPLKGAKFELYKGEPGKGTKLGDLVSDDQGKLTATDLTLGKYYFVEVPSEVVVGSDKEPTADQYLLGADARNDAHNKLTFEITNDGVTSDLKASYVNYKAPVIDKTVTNGTGQEHSFQIGDAVNYQGTIHIPTDIAGGADGITVNGVKSETSPYSVFKWGDTAGQGLSYVAAKANIKVTNKDGSVVLKENTDYKIQNSENGFVIDFIVNNGQVSDTVASLHGQDLQMTYNMYVNDSAAVANPLTNSVDFVYNNNPFNQEEHHEKTKADVVTYGAKFLKVDSGLFGTGIKATPLEGAEFAAKNAEGKYYGGLVDTDKDGVKEAVWVDDVANAAILKSDKEGHFEITGLTEGKYSLEETKAPENYQKLTKEISFKVDKDSYKEENRITIKNNQKASVPMTGSNGFQTYVLISCLLLGAGALSAVVYFKKKA Kraken2_NZ_CP040873.1 IMICODJL_49494 Prodigal:2.6 47214 47966 + VFG042987(gb|ACI49670) 99.2 7.32e-177 (ACI49670) putative pilus-dedicated sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MIIRKPKKKRIMGKWIIAFWLLSAVGVLLLMPAEASVAKYQQNQQIAAIDRTGTAAETDSSLDVAKIELGDPVGILTILSISLKLPIYDGTSDKILENGVGITEGTGDITGGNGKNPLIAGHSGLYKDNLFDDLPSVKKGEKFYIKVDGEQHAYQIDRIEEVQKDELQRNFVTYLEPNPNEDRVTLMTCTPKGINTHRFLVYGKRVTFTKSELKDEENKKQKLSWKWLLGSTVFLSVMIIGSLFVYKKKK Kraken2_NZ_CP040873.1 IMICODJL_49495 Prodigal:2.6 47982 48743 + VFG042986(gb|ACI49673) 98.0 3.9300000000000006e-157 (ACI49673) cell wall-associated LPXTG-like protein VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MRNRKWLFVCAAALFSFTAYTQLTFADRQESTDSTEQTIQTSDSSTIQSSDETVDSSTVDSSEEPKIAEDDQIVKQTIHVQKIISSEQLDNQGQKLEKQEGVNGAKFSVYDVSDILQKMDVKDLSTDQIESQLKDRVKKLSSDQLKLVSNGETKTIDQQAGVFEFSVEVQANQKQAYYIVNESSPENISNSEDILLLTPVSDKNGEFLKDVWIYPKSEASQPKEEVKKIVSTGVKKNFFENCWDFVTHLFSRD Kraken2_NZ_CP040873.1 IMICODJL_49496 Prodigal:2.6 48756 49016 + VFG042985(gb|ACI49669) 98.8 2.15e-49 (ACI49669) hypothetical hydrophobic peptide VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKLIKLLLFNLSCLTAVFLYCGLLFSQLSILPSYQLYLMRILNIPAASMPLDIMEKLIRNPLFTTINLIVIVGISLVIYKKEGMKG Kraken2_NZ_CP040876.1 IMICODJL_49528 Prodigal:2.6 7349 8020 + VFG042989(gb|ACI49672) 99.1 1.27e-159 (ACI49672) putative housekeeping sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKKWLFGFLGVALIVFCSVFGYVSYQKHEGEVFKQNIEKKMPVDQINAHAKSYKEDATNVNNDMSLGQMLSIQKEAIKMGVNKQVFAQIQIPALGLALPIFKGANQYTLSLGAATYFYEDAKMGKGNYVLAGHNMEMPGVLFSDIQKLSLGEVMDLVSNDGVYRYKVTRKFIVPEYFKLIDGVPEENSFLSLPKKGEKPLLTLFTCVYTSQGKERYVVQGELQ Kraken2_NZ_CP040876.1 IMICODJL_49529 Prodigal:2.6 8073 10049 + VFG042988(gb|ACI49671) 98.6 0.0 (pilA) PilA VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MAINRYVKKAGMLVGMLGIIASCFQGYQAYAEDVTQKTPPEKVNITVHKLMYDQGTQLNVDIDGIKNDGYTHDQYPTGVTKYNKADYGDVEFTLGNITNQVLPTEDSDLTNAKVDEIVKDVEDKGSNSEYVKNATNKITSAVDENGVITFADQPAYVNSKGNVYVVYESKSAAGLVTQKAKPMVVIAPMTDNTGSGFLKDIHLYPKNIVSKLSFELTKFGDDGTAQSKQTPLKGAKFELYKGEPGKGTKLGDLVSDDQGKLTATDLTLGKYYFVEVPSEVVVGSDKEPTADQYLLGADARNDAHNKLTFEITNDGVTSDLKASYVNYKAPVIDKTVTNGTGQEHSFQIGDAVNYQGTIHIPTDIAGGADGITVNGVKSETSPYSVFKWGDTAGQGLSYVAAKANIKVTNKDGSVVLKENTDYKIQNSENGFVIDFIVNNGQVSDTVASLHGQDLQMTYNMYVNDSAAVANPLTNSVDFVYNNNPFNQEEHHEKTKADVVTYGAKFLKVDSGLFGTGIKATPLEGAEFAAKNAEGKYYGGLVDTDKDGVKEAVWVDDVANAAILKSDKEGHFEITGLTEGKYSLEETKAPENYQKLTKEISFKVDKDSYKEENRITIKNNQKASVPMTGSNGFQTYVLISCLLLGAGALSAVVYFKKKA Kraken2_NZ_CP040876.1 IMICODJL_49530 Prodigal:2.6 10064 10816 + VFG042987(gb|ACI49670) 99.2 7.32e-177 (ACI49670) putative pilus-dedicated sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MIIRKPKKKRIMGKWIIAFWLLSAVGVLLLMPAEASVAKYQQNQQIAAIDRTGTAAETDSSLDVAKIELGDPVGILTILSISLKLPIYDGTSDKILENGVGITEGTGDITGGNGKNPLIAGHSGLYKDNLFDDLPSVKKGEKFYIKVDGEQHAYQIDRIEEVQKDELQRNFVTYLEPNPNEDRVTLMTCTPKGINTHRFLVYGKRVTFTKSELKDEENKKQKLSWKWLLGSTVFLSVMIIGSLFVYKKKK Kraken2_NZ_CP040876.1 IMICODJL_49531 Prodigal:2.6 10832 11593 + VFG042986(gb|ACI49673) 98.0 3.9300000000000006e-157 (ACI49673) cell wall-associated LPXTG-like protein VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MRNRKWLFVCAAALFSFTAYTQLTFADRQESTDSTEQTIQTSDSSTIQSSDETVDSSTVDSSEEPKIAEDDQIVKQTIHVQKIISSEQLDNQGQKLEKQEGVNGAKFSVYDVSDILQKMDVKDLSTDQIESQLKDRVKKLSSDQLKLVSNGETKTIDQQAGVFEFSVEVQANQKQAYYIVNESSPENISNSEDILLLTPVSDKNGEFLKDVWIYPKSEASQPKEEVKKIVSTGVKKNFFENCWDFVTHLFSRD Kraken2_NZ_CP040876.1 IMICODJL_49532 Prodigal:2.6 11606 11866 + VFG042985(gb|ACI49669) 98.8 2.15e-49 (ACI49669) hypothetical hydrophobic peptide VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKLIKLLLFNLSCLTAVFLYCGLLFSQLSILPSYQLYLMRILNIPAASMPLDIMEKLIRNPLFTTINLIVIVGISLVIYKKEGMKG Kraken2_NZ_CP040876.1 IMICODJL_49533 Prodigal:2.6 11863 13953 + VFG042984(gb|ACI49668) 98.0 0.0 (ACI49668) minor pilin subunit VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MNFKHSWTRRLKYVFPIMMMLGTLFGLKTANVFAEKVIVDPSNPIQNVKNNFIIPKDVPNAKTNITVSGASKVYKYHVDANKGGFTDDYVGLVEGNKNIRYPSFQKEYGETNLVLEGVTTNTKVNIDYGKIGTYNGKKVNIKLVLSNIHLYSDTLPWNLLDNNYTKTHFRDDGYKNTNGAMSKSKKRTVLWISDNLFSGIVYHSTQMNVQLVATYEDGSPVQFSGDTFISFNSLNPAGGKSTDLKGEYAHYDKMNTTDWYVRKDTVLSEFKSFYNNLNVVGGHPGGSSKLTQADNDFNNLHDKLGDPKFGQGTVSFKISEANPTFVIGSSNVQTWFTLSSATIFSVVPDQPEKTEVDKDGNNVNDKMLQVGDTIQYRIKQKVNRLGVDLLAVYDRFELIDNLPKEVDYVDAHVECGSNKKFDVSGEVTYDKTKHQVKYAAKADTLKNRMKYNGETYELVINVKVNELANQNSVAKNQGTSIINKVEKDTNIITVYFPKIPVKEVQQDGKDVNGRNDGKKGTPTAPLNAGSEVQYLVTQKWHTKGVDAASDHYKQFSIQDPIEARLTYKEGSAQVIDKSTGKDITSEGTLTYDSNSRTLKWEASADFLSNNLLDGREIQLIFTAKTPLQSEKNIDNQAVAAVDNVSNKTNVVTIGVDPNLPQVIVPKTGSTHLVTILAVSLLLLVLATFSYAVLKFN Kraken2_NZ_CP040877.1 IMICODJL_49688 Prodigal:2.6 46125 48215 - VFG042984(gb|ACI49668) 99.6 0.0 (ACI49668) minor pilin subunit VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MNFKHSWTRRLKYVFPIMMMLGTLFGLKTANVFAEKVIVDPSNPIQNVKNNFIIPKDVPNAKTNITVNGASKVYKYHVDANKGGFTDDYVGLVEGNKNIRYPSFQKEYGETNLVLEGVTTNTKVNIDYGKIGTYNGKKVNIKLVLSNIHLYSDTLPWNLLDNNYTKTHFRDDGYKNTNGAMSKSKKRTVLWISDNLFSGIVYHSTQMNVQLVATYEDGSPVQFSGDTFISFNSLNPAGGKSTDLKGEYAHYDKMNTTDWYVRKDTVLSEFKSFYNNLNVVGGHPGGSSKLTQADNDFNNLHDKLGDPKFGQGTVSFKISEANPTFVIGSSNVQTWFTLSSATIFSVVPDQPEKTGVDKNGNNVNDKMLQVGDTIQYRIKQKVNRLGVDLLAVYDRFELIDNLPKEVNYVDAHVESGTNKKFDVSGEVTYDKTKHQVKYAAKADTLKNRMKYNGETYELVINVKVNELANQNSVAKNQGTSIINKVEKDTNIITVYFPKIPVKEVQQNGKDVSGRNDGKKGTPTAPLNAGSEVQYLVTQKWHTKGVDAASDHYKQFSIQDPIEARLTYKEGSAQVIDKSKGKDITSEGTLTYDSNSRTLKWEASADFLSNNLLDGREIQLIFTAKTPLQSEKNIDNQAVVAVDNVSNKTNVVTIGVDPNLPQVIVPKTGSTHLVTISAVSLLLLVLATFSYAVLRYI Kraken2_NZ_CP040877.1 IMICODJL_49689 Prodigal:2.6 48212 48472 - VFG042985(gb|ACI49669) 98.8 2.15e-49 (ACI49669) hypothetical hydrophobic peptide VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKLIKLLLFNLSCLTAVFLYCGLLFSQLSILPSYQLYLMRILNIPAASMPLDIMEKLIRNPLFTTINLIVIVGISLVIYKKEGMKG Kraken2_NZ_CP040877.1 IMICODJL_49690 Prodigal:2.6 48485 49240 - VFG042986(gb|ACI49673) 99.2 3.2500000000000004e-160 (ACI49673) cell wall-associated LPXTG-like protein VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MRNRKWLFVCAAALFSFTAYTQLTFADRQESTDSTEQTIQTSDSSTIQSSDETVDSSTVDSSEEPKIAEDDQIVKQTIHVQKIISSEQLDNQGHEKQEGVNGAKFSVYDVSDILQKMDVKDLTTDQIESQLKDRVKKLSSDQLKLVSNGETKTIDQQTGVFEFSIEVQANQKQAYYIVNESSPENISNSEDILLLTPVSDKNDEFLKDVWIYPKSEASQPKEEVKKIVSTGVKKNFFENCWDFVTHLFSRD Kraken2_NZ_CP040877.1 IMICODJL_49691 Prodigal:2.6 49256 50008 - VFG042987(gb|ACI49670) 99.2 6.27e-178 (ACI49670) putative pilus-dedicated sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MIIRKPKKKRIMGKWIIAFWLLSAVGVLLLMPAEASVAKYQQNQQIAAIDRTGTAAETDSSLDVAKIELGDPVGILTIPSISLKLPIYDGTSDKILENGVGITEGTGDITGGNGKNPLIAGHSGLYKDNLFDDLPSVKKGEKFYIKVDGEQHAYQIDRIEEVQKDELQRNFVTYLEPNPNEDRVTLMTCTPKGINTHRFLVYGKRVTFTKSELKDEENKQQKLSWKWLLGSTVFLSVMIIGSLFVYKKKK Kraken2_NZ_CP040877.1 IMICODJL_49692 Prodigal:2.6 50023 51999 - VFG042988(gb|ACI49671) 99.5 0.0 (pilA) PilA VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MAINRYVKKAGMLVGMLGIIAGCFQGYRAYAEDVTQKTPPEKVNITVHKLMYDQGTQLNVDIDGIKNDGYTHDQYPTGVTKYNKADYGDVEFTLGNITDQVLPTEDSDLTNAKVDEIVKDVEDKGSNSEYVKNATNKITSAVDENGEITFADQPAYVNSKGNVYVVYESKSAAGLVTQKAKPMVVIAPMTDNTGSGFLKDIHLYPKNIVSKLSFELTKFGDDGTAQSKQTPLKGAKFELYKGEPGKGTKLGDLVSDDQGKLTATDLTLGKYYFVEVPSEVVVGSDKEPTADQYLLGADARNDAHNKLTFEITNDGVTSDLKASYVNYKAPVIDKTVTNGTGQEHSFQIGDAVNYQGTIHIPTDIAGGADGITVNGVKSETSPYSVFKWGDTAGQGLSYVAAKANIKVTNKDGSVVLKENTDYKIQNSENGFVIDFIVNNGQVSDTVASLHGQDLQMTYNMYVNDSAAVVNPLTNSVDFVYNNNPFNQEEHHEKTKADVVTYGAKFLKVDSGLFGTGIKATPLESAEFAAKNAEGKYYGGLVDTDKNGVKEAVWVDDVANAAILKSDKEGHFEITGLTEGEYSLEETKAPENYQKLTKEISFKVDKDSYKEENRITIKNNQKASVPMTGSNGFQTYVLISCLLLGAGALSAVVYFKKKA Kraken2_NZ_CP040877.1 IMICODJL_49693 Prodigal:2.6 52052 52723 - VFG042989(gb|ACI49672) 98.7 8.600000000000001e-158 (ACI49672) putative housekeeping sortase VF0744 PilA-type pili (PGS1, pilin gene clusters 1) VFC0001 Adherence MKKWLFGFLGVALIVFCSVFGYVSYQKHEGDVFKQNIEKKMPVDQINAHAKSYKEDATNVNNDMSLGQMLSIQKEAIEMGVNKQVFAQIQIPALGLALPIFKGANQYTLSLGAATYFYEDAEMGKGNYVLAGHNMEMPGVLFSDIQKLSLGEVMDLVSNDGVYRYKVTCKFIVSEYFKLIDGVPEENSFLSLPKKGEKPLLTLFTCVYTSQGKERYVVQGELQ Kraken2_NZ_CP079204.1 IMICODJL_50595 Prodigal:2.6 65024 66061 - VFG026325(gb|WP_009889299) 72.2 1.34e-185 (gmd) GDP-mannose 4,6-dehydratase VF0436 Capsule I Type I O-polysaccharide VFC0258 Immune modulation A key virulence determinant and that loss of capsule production results in severe attenuation in animal models of disease Plays a role in reducing B. pseudomallei phagocytosis by host cells by preventing complement factor C3b deposition on the surface of the bacterium MTKSAIITGISGQDGAYLAENLLDRGYKVYGTYRRTSSVNFWRIEELGIQDHPNLHLVEYDLTDMGSAIRLIEQSEAIEIYNLAAQSFVGVSFDQPIATGMITGLGAAYLLEAIRTVNKSIRFYQASTSEMFGKVQAIPQTEDTPFYPRSPYGVAKLYAHWLTVNYRESFDIFGSSGILFNHESPLRGREFVTRKITDTVAKIHLGQAELLELGNLDAERDWGYAKDYVEGMRLILQHDTPDTFVLATNQKQSVRSFVELAFRQIGVMIEWSGAAEDEVGRDAATGKLLVRVNPRFYRPAEVELLIGDPAKATAALGWRSQTSLEELCRIMVEADVRRNKSGHSF Kraken2_NZ_CP079204.1 IMICODJL_50598 Prodigal:2.6 67351 68403 + VFG049107(gb|WP_015958694) 66.5 1.93e-172 (rfbB) dTDP-glucose 4,6-dehydratase VF0561 LPS VFC0258 Immune modulation In K. pneumoniae there are nine main O-serotypes. Three of these, O1, O2, and O3, are responsible for almost 80% of all Klebsiella infections.; Compared with other Enterobacteriaceae, such as Escherichia coli 161 defined O serotypes and Shigella flexneri at least 47 O serotypes, Klebsiella has a surprisingly low number of reported O serotypes which promises a more viable alternative for vaccine development compared with K-antigen-based vaccines; The O-antigen biosynthesis enzymes are encoded on the rfb locus. Resistant to serum complement; also play a role in protecting bacteria from antimicrobial peptides, including polymyxin antibiotics MRIFVTGGAGFIGSALVRHLIENTTHEVLNFDKLTYAGTLTTVERVAASERYQFVQGDICDAGAVRTAIETFRPDIITHLAAESHVDRSIDGPGAFVQTNVVGTYTMLAEARAWWLSLDDAGKAAFRFHHISTDEVYGTLGDTGLFTEETPYDPRSPYSASKAGSDHLVSAWGHTFGLPVLITNCSNNYGPYHFPEKLIPLMIAKALDGEPLPIYGKGDQVRDWLYVEDHVRALQAVFERGEPGRTYNVGGHNERQNIEVVRTLCAILDELRPRNDGKSYADQMTEVADRPGHDKRYAIDASRIGAELGWTPVETFETGIRKTVQWYLANESWWRPLVANKASERRGVAA Kraken2_NZ_CP079204.1 IMICODJL_50600 Prodigal:2.6 69306 70172 + VFG005898(gb|WP_002904719) 67.5 2.92e-140 (rfbA) glucose-1-phosphate thymidylyltransferase RfbA VF0144 Capsule VFC0258 Immune modulation Ninety different capsule types have been identified. Each has a structurally distinct capsule, composed of repeating oligosaccharide units joined by glycosidic linkages Resistant to complement deposition and masks cell wall-associated complement from being recognized by the complement receptors on phagocytes MKGIILAGGSGTRLHPATLAVNKQLLPVYDKPMIYYPLSVLMLAGIRDILIISSPEFLDNYRRLFGDGSAFGLTMSYAEQPSPDGLAQAFTIGADFIGDDQVALVLGDNIFFGAHLTDLLNSAVARPKGATVFSYRVEDPERYGVVEFGEGGRAVSLEEKPARPKSNHAVTGLYFYDNRVVEFARNLKPSARGELEITDINRLYMEAGDLYVEQMGRGYAWLDTGTHDSLLEAGEFVRTLQHRQGVQVACLEEIAYEMGFISAEQAREAGERFKKTAYGRAILNAVKG Kraken2_NZ_CP079204.1 IMICODJL_50621 Prodigal:2.6 93629 94795 + VFG048789(gb|WP_014838943) 66.2 5.49e-183 (ugd) UDP-glucose 6-dehydrogenase VF0560 Capsule VFC0258 Immune modulation The Klebsiella polysaccharide capsule is produced through a Wzy-dependent process, for which the synthesis and export machinery are encoded in a single 10-30 kb region of the genome known as the K locus.; 78 distinct capsule phenotypes have been recognized by serological typing, but many isolates are serologically non-typable.; capsular serotypes vary substantially in the degree of serum resistance; K1, K2 and K5 are highly serum resistant and are associated with hypervirulent strains that differ from classical K. pneumoniae in that they commonly cause community-acquired disease. Assisting in evading the host immune system by protecting bacteria from opsonophagocytosis and serum killing MKIAVFGLGYVGMSNAVLLAQHNSVVAVDISPERVAMVNARTSPIVDVELQDFLTSRTLDLSATTDAAEALAGADYVIVATPTNYDVDTNSFNTSSVEAVIALAKTHAPEATVVVKSTIPVGFVDDVRTRLDTQQVIFSPEFLREGRALYDNLHPSRIIVGEQSERARIFADLLVQGAEKQDIAVLFTGTREAEAIKLFANTYLAMRVAFFNELDSYAIAGNMDTRQIIDGIGLDPRIGTHYNNPSFGYGGYCLPKDTKQLLANYSSVPQNLMRAIVDANRTRKDFLADQIIAKKPSRVGIFRLTMKAGSDNFRQSSIQGIMKRIKAKGIEVVVFEPSLAEDSFFGSKVYRDLSAFKQDSDVIIANRNDPELADVADKLFTRDIFGSD Kraken2_NZ_CP058973.1 IMICODJL_50725 Prodigal:2.6 109094 111013 - VFG043573(gb|NP_219906) 60.8 3.91e-237 (dnaK) chaperone protein DnaK VF0713 Adherence; porin VFC0001 Adherence MGRIIGIDLGTTNSCVAVLDGDKARVIENAEGDRTTPSIIAYTQDGETLVGQPAKRQAVTNPTNTLFAIKRLIGRRFEDEEVQRDIGIMPFKIVKADNGDAWVEARGEKRAAPQISAEVLKKMKKTAEDFLGEAVTEAVITVPAYFNDSQRQATKDAGRIAGLEVKRIINEPTAAALAYGMDKNKGENVVAVYDLGGGTFDISIIEIDEVEGEHTFEVLATNGDTHLGGEDFDNRVINYLVEEFKKDQGIDLKNDPLAMQRVKEAAEKAKIELSSAQQTEVNLPYVTADASGPKHMNVKVTRAKLESLVEDLVTKSIEPLKRALADADLSVSDINDIILVGGQTRMPLVQKTVAEFFGKEPRKDVNPDEAVAVGAAIQGGVLAGDVKDVLLLDVSPLSLGIETMGQVMTALIEKNTTIPTKKSQVFSTAEDNQSAVTIHVLQGERKRASDNKSLGQFNLEGIRPAQRGTPQIEVTFDVDADGILHVSAKDKDTGKEQKITIQASSGLSDEEVEKMVRDAEAHAEEDKKFEELVATRNQADAMVHGTRKQIEEAGDALPAEDKEAIEAAVSELEAAIKSDKKEEIEAKTQALAEKSQKLMEIAQAKAQQQGGADAGAQQSSAKQDDDVVDAEFEEVKDDK Kraken2_NZ_CP058973.1 IMICODJL_50763 Prodigal:2.6 152591 155722 - VFG049146(gb|WP_012968813) 63.0 0.0 (acrB) acriflavine resistance protein B VF0568 AcrAB VFC0325 Antimicrobial activity/Competitive advantage May mediate resistance against host-derived antimicrobial peptides; associated with antibiotic resistance MSRFFIDRPIFAWVLAIVVMLAGILAIKSLPVAQYPSIAPPAISIQANYPGASARTLEDTVTQVIEQKMKGLDGLLYMSSTSESNGSATLTLTFSADTDPDIAQVQVQNKLSLATPLLPEEVQRQGVSVAKSARNFLMVVGFVSEDGSMNNIDIGDYVSSNVLDIISRVNGVGEVQLFGSQYAMRIWLDPSKLQKYALTPADISAAISAQNAQVSAGQLGALPAVDGQQLNATVTAQSRLQTPEQFRDIFVKTNPDGSVVRLSDVAKVELGGENYGVVARFNGKPASGLGVKLASGANALDTADGVKAALAELEPFFPEGLTTVVPYDTTPFVSLSIEKVVSTLIEAVVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAILQVFGYSINTLTMFAMVLAIGLLVDDAIVVVENVERVMTEENLSPLEATRKSMDEIKGALVGIAMVLSAVFVPMAFFAGSTGVIYRQFSITLVTAMSLSVLVALILTPALCATMLKPSHVHNDKSLFGRFFLGFNRGFDKTNAGAQGFVARMIKHSKRYLLCYGLIVGGMVYIFSQLPSAFLPDEDQGILFNQVSLPAGSTTEQTLKVVEKMEHHFLEDQSEAVKSIFTVTGFSFAGSGQNAAIGFVGLKHWDERQRPDLSVGAVAGKAMGYFSTIKEAFVFAFPPPAVVELGTANGFTLFLQDRVGLGHDKLLEARNMFLGMAAKNPVLSGVRPNGQEDKPELELDIDLAKAEALGLTQTDINNTLSTAWGSRYVNDFIDRGRVKKVYLQGTPESRMVPEDLDKWYVRNANGDMVPFTAFAHSYWTYGSPRLERYNGFSAMEIQGAAAPGYSTGQAMVEVEKIVKQLPPGVAFEWTGISYEERLSGGQAPLLYALSLLVVFLCLAALYESWSVPAAVMLIVPLGVFGAGVASFVFNLSNDIYLQVGLLTTIGLASKNAILIVEFAIHKMDEGMKLVDAAIAAIRLRLRPIFMTSMAFVCGVLPLAIASSAGSGAQNALGIAVIGGTLASSTIVVLFVPLFFVLVRRVFPGKQKVNSEEQA Kraken2_NZ_CP058973.1 IMICODJL_50788 Prodigal:2.6 183105 186251 - VFG037720(gb|WP_001027056) 61.8 0.0 (adeG) cation/multidrug efflux pump VF0504 AdeFGH efflux pump VFC0271 Biofilm Belongs to resistance-nodulation-cell division (RND)-type efflux system; RND efflux systems, composed of an inner membrane protein (RND pump) linked by a periplasmic adaptor protein (PAP) to an outer membrane factor (OMF), can extrude a wide range of substrates often unrelated in structure; To date, three Acinetobacter drug efflux (Ade) RND systems, AdeABC, AdeFGH, and AdeIJK, have been characterized in A. baumannii Play a potential role in the synthesis and transport of autoinducer molecules during biofilm formation MKFSHFFIQRPIFAAMLSLIFLIAGAISLFQLPVSEYPEVVPPTVVVTASYPGANPTVIAETVATPLEQEINGTENMLYMFSQATSDGRMTLTVTFALGTDLDRAQVQVQNRVNSALPRLPQEVQRLGVVAEKSSPDLTMVVHLYSPEKTHDTTYLANYADLYIKDQIARLPGVGDVRMFGGGQYSMRVWLNPDALSARDLTAMDVVNALRAQNQQVAAGSLGAQPTSKSNQFQILMNVKGRLSSQEEFENVIIKVGEQGQLTRLSDVARLELGQDTYALRAMLDGQPALAMPVFQRPGSNAIELSDQVRETMKVLAKDFPSGVEYDIVYDPTIFVRGSIDAVIKTLLEAIALVVIVVVVFLQTWRASVIPLIAVPVSLIGTFAVMQWLGVSINTLSLFGLVLAIGIVVDDAIVVVENVERNIEQGLSPLEATRVAMTEVTGPIIAIALVLCAVFIPTAFITGLSGQFYKQFALTITISTVISAFNSLTLSPALSALLLKGHDAKPDRLTKLLNRLFGNWLFKPFNRVFDKGANGYEKLVQKLIRMSVIVLVAYVALVGGTVKLFDAVPGGFIPQQDKQYLVAVAQLPDAASLDRTQEVVQEMEKIALQVPGVANTVSFPGLSVNGFTNSPNSGIVFTPLAPFEERQDPSMSAMAIAAQLNQKFAAIDEAFVAVFPPPPIQGLGTTGGFKLQIEDRANKGFEALFNSLQATITKAQQDPALMGLYSSFRIQVPQMDIDIDREQALIQGIPLDEVFNALQVYLGSVYVNDFNLFGRTYQVNAQADADYRQDPEQILNLKVRNRMGEMVPLGSVLTVTPTTGPDRVMHYNGYPTAELNGSPAPGYSSGQAQQAIEAILADTLPNGIEFEWTEVTYQQILAGNTMVYVFPLVVLLVFMVLAAQYESLRLPLAIILIVPMTIFSALLGVWFVGDDNNIFTQIALIVLVALASKNAILMVEFARDQHKTGMSHLEAIIKACRLRLRPILMTSIAFTAGVVPLVLATGAGAEMRHAMGNAVFSGMIGVTVFGLLFTPVFYMLVTKKSQKEQHDA Kraken2_NZ_CP058973.1 IMICODJL_51337 Prodigal:2.6 838446 840623 - VFG001862(gb|WP_015444101) 72.8 0.0 (katB) catalase-peroxidase KatB VF0168 KatAB VFC0282 Stress survival A periplasmic catalase, expressed maximally during the post-exponential phase; important for intracellular survival and transmission MSNGKTGQCPVMHGSNTVTAQSNTNWWPNALNFDILHQHDSKTSPYGKDFNYAEAFKSLDLEAVKTDLKNLMTESQPWWPADWGHYGGLMIRMAWHSAGSYRLEDGRGGGGTGNQRFAPLNSWPDNANLDKARRLLWPIKKKYGNKLSWADLMILAGNMAYESMGLKTFGFAGGREDIWHPEKDIYWGAEKEWLASSDERYSNVEKPNTMENPLAAVQMGLIYVNPEGVNGNPDPLKTAEQVRETFARMAMNDEETAALTVGGHTVGKTHGNGSEANVGPEPEAADVYEQGLGWNNHTSRGIGRDTMTSGIEGAWTTHPTKWDNGYCYLLLNYDWELKKSPAGAWQWEPINIKEEDKPVDVEDPSIRLNPIMTDADMAMKMDPTYRKIIERFNDDFEYFSDVFARAWFKLTHRDLGPKSRYLGADVPNEDLIWQDPIPAVDYTLTDSEISELKTKLLNCGVSQADLITTAWDSARTYRCSDHRGGANGARIRLAPQKDWQGNEPKRLANVLSALESVQADLSKPVSLADLIVLGGSAAIEQAAKAAGVDVTVPFAPGRGDATDDMTDAESFDVLEPIHDGFRNWLKEEYAVSAEELMLERTQLMGLTAPEMTALVGGMRVLGTNYDGTLHGVFTDNVGTLSTDFFVNLTDMAFTWKPLGKGYYDIIERSTGVTKWTATRVDLVFGSNSILRAYAEFYAQDDNKARFVHDFVDAWVKVMNADRFDL Kraken2_NZ_CP102391.1 IMICODJL_52994 Prodigal:2.6 70732 71754 + VFG013197(gb|WP_011608705) 66.5 1.41e-154 (hemB) porphobilinogen synthase VF0758 Heme biosynthesis VFC0272 Nutritional/Metabolic factor MSIIIPGSFPARRLRRSRTHSFSRRLVAENQLTVNDLILPVFIIEGQNLRQEVPSMPGVFRLSVDMLLHDAAQFVQAGIPAIALFPCIESSAKSLMADASWDPSGLVPRTVRALKKAFPELGVITDVALDAYTSHGQDGIIDEHGYVLNEPTKEILTRQALTHAEAGADIVAPSDMMDGRIGHIRQAFETNGLLTIQIMAYSAKYASNYYGPFREATQSAMALGKRDKKNYQMDPANAMEALHEIAQDLQEGADMVMVKPGMPYLDIIREARKTFAVPVFAYQVSGEYAMHMAAFRHGWLDEEQTVLESLICFKRAGADGILTYFASSVAQWLNQHQREY Kraken2_NZ_CP102391.1 IMICODJL_53012 Prodigal:2.6 81355 82674 + VFG048547(gb|WP_004213617) 99.8 0.0 (iroN) salmochelin receptor IroN VF0563 Sal Salmochelin VFC0272 Nutritional/Metabolic factor Salmochelin is a glycosylated Ent that requires the iroA locus for production and transport A major trigger of inflammation and bacterial dissemination induced during K. pneuminiae lung infection Inducing dissemination through chelation of host cellular iron, leading to inactivation of iron-dependent prolyl hydroxylases and the master transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) stabilization in lung epithelial cells. HIF-1alpha controls vascular permeability and inflammatory gene expression MFAPSLAKSRKETNRLYRQNYGIAHNGIWDWGQSRFGVYYEKTNNNRMNEGLSGGSEGRILADEKFTTNRLSSWRTSGEINIPLNEPVDQTLTVGVEWSRDKLDAPSSTSLTVNDSDIGGISGSAADRSSKNHSQISALYIDDNIEPVPGTNIISGLRFDYLNESGGNFSPSLNLSQELGDYFKVKAGIARTFKAPNLYQSSKGYLLYSKGNGCPKDITSGGCYLKGNKDLDPEISINKEIGLEFAWEDYYASVTYFRNDYQNKIVAGDNAIGQTASGAYILQWQNGGKALVDGIEASMAFPLVKDRLNWNTNATWMITSEQKDTGNPLSIIPKYTINNSLDWTITQAFSASVNWTLYGRQKPRTHAESRSEDTRGMSGKVLGAYSLVGTNFNYDINKNLRLNIGVSNILDKQIYRTSEGASTYNEPGRAYYVGAVVSF Kraken2_NZ_CP102391.1 IMICODJL_53016 Prodigal:2.6 85007 85594 - VFG048996(gb|WP_004213609) 99.5 7.77e-146 (rmpA) regulator of mucoid phenotype RmpA VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MLTDDYFFYYGLKQLTGLPLFHITYEGVVNKSIAIKHKRNIRVLVDSRIFYSGKWGGYKMLRGSLNMISQWMWLDVSGGGRFYPKGCDYDIYVNMQGNVKNNIEKLYFAFLKKNVSRIVNHYPRLTKKEQAVLQCLLKNGGINEIKSQLKIEEKTLSCYQSKITRKFGCKRYIRFMYLYSLNKEMVDERWLMPSI Kraken2_NZ_CP102391.1 IMICODJL_53039 Prodigal:2.6 103970 105751 + VFG048600(gb|WP_004213920) 100.0 0.0 (iucA) aerobactin Synthetase IucA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MGIFIDKILIIMTSEICLTMTLPTKTSTLDVAAQCFLNSLVRETKDWRLTEYQPTQLIIPLGEQQALHFRVAYFSPTQHHRFEFPARLVTASGSHPVDFATLSRLIVDKLQHQLLLPATSCETFHQRVMESHAHTQQAIDARHDWAALREKALNFGEAEQALLVGHAFHPAPKSHEPFNQQEAERYLPDFAPHFPLRWFAVNKTQIAGESLHLNLQQRLTRFAAENAPQLLNELSDNQWLFPLHPWQGEYLLQQEWCQELVAKGLIKDLGEAGAPWLPTTSSRSLYCATSRDMIKFSLSVRLTNSVRTLSVKEVKRGMRLARLAQTDDWQTLQARFPTFRVMQEDGWAGLRDLHGNIMQESLFALRENLLVDQPQSQTNVLVSLTQAAPDGGDSLLVAAVKRLSDRLGITAQQAAHAWVDAYCHQVLKPLFTAEADYGLVLLAHQQNILVQMLGDLPVGLIYRDCQGSAFMPHAAGWLDTIGEAQAENVFTREQLLRYFPYYLLVNSTFAVTAALGAAGLDSEANLMARVRTLLAEMRDQVTHKTCLNYVLENPYWNVKGNFFCYLNDHNENTIVDPSVIYFDFANPLLAQEG Kraken2_NZ_CP102391.1 IMICODJL_53040 Prodigal:2.6 105752 106699 + VFG048603(gb|WP_004213921) 100.0 2.6100000000000003e-248 (iucB) N-acetyltransferase IucB VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MSKANIVHSGYGLRCEKLDKPLNLSWGLDNSAVLHWPGPLPTGWLRDALEQIFIAAPQLSAVVLPWAEWREEPQALTLFGQVKSDIIHRTAFWQLPLWLSSPANRASGEMVFDAEREIYFPLRPPRPQGEVYRRYDPRVRKTLSFRVADPVLDAERFTRWMNDPRVEYFWEQSGSLEVQTAYLERQLTGKHAFPLIGCFDDRPFSYFEIYWAAEDRIGRHYSWQPFDRGLHLLVGEQQWRGAHYVQSWLRGLTHYLLLDEPRTQRTVLEPRADNQRLFRHLEPAGYRTIKEFDFPHKRSRMVMADRHHFFTEVGL Kraken2_NZ_CP102391.1 IMICODJL_53041 Prodigal:2.6 106699 108432 + VFG048606(gb|WP_004213922) 100.0 0.0 (iucC) aerobactin siderophore biosynthesis protein IucC VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MNHKDWDFVNRQLVAKMLAELEYEQVFHAESQGDGRYCINLPGAQWRFSAERGIWGWLWIDAQTLRCADEPVLAQTLLMQLKPVLSMSDATVAEHMQDLYATLLGDLQLLKARRGLSASDLIDLDADRLQCLLSGHPKFAFNKGRRGWGKEALERYAPEYANTFRLHWLAVKREHMVWRCDSELDIQQLLAAAMDPQEFARFNQVWQDNGLDNDWLPLPVHPWQWQQKISLDFIADLAEGRMVSLGEFGDLWLAQQSLRTLTNASRQGGLDIKLPLTIYNTSCYRGIPGKYIAAGPLASRWLQQVFATDATLKQSGAVILGEPAAGYVSHEGYAALAQAPYRYQEMLGVIWRENPCRWLKPDESPILMATLMECDENNQPLIGAYIDRSGLDAETWLTQLFRVVVVPLYHLLCRYGVALIAHGQNITLAMKKGVPQRVLLKDFQGDMRLVKDAFPEMDSLPQEVRDVTARLSADYLIHDLQTGHFVTVLRFVSPLMARLGVPERRFYQLLAAVLSDYMQEHPQMSARFALFSLFKPQIIRVVLNPVKLTWHDQDGGSRMLPNYLEDLQNPLWLATRD Kraken2_NZ_CP102391.1 IMICODJL_53042 Prodigal:2.6 108436 109713 + VFG048609(gb|WP_004213923) 100.0 0.0 (iucD) lysine 6-monooxygenase IucD VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MTNTVDFIGIGIGPFNLSIAALSHQAEGLSSRFFDGRPHFAWHPGMLVPDCHMQTMFLKDLVSAVAPTSPYSFVNYLVKRKKFYRFLTTELRTVSRDEFSDYLRWAAEGMNNLHFNHTVESIDFDERHQRFVVQTSQGESVARNICLGIGKQPHLPPCVKTATQTCFHASEMSLRRPDLGGKRVSVVGGGQSGADLFLNALRGEWGDVAEISWVSRRNNFNALDEAAFANEYFTPEYVSGFVGLNERARQKMLDEQKMTSDGITADSLLTIYRELYHRFEVLRQPRNARLLPSRSVTGLESRGQSWQLLLEHHLDNGYDTLESDVVIFATGYRPALPQILSPLMSRIAMRDECNFKVRDDFTLEWNGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARILNRVMGRDLFDLSMPPALIQWRSGT Kraken2_NZ_CP102391.1 IMICODJL_53043 Prodigal:2.6 109798 111996 + VFG048621(gb|WP_004213924) 100.0 0.0 (iutA) ferric aerobactin receptor IutA VF0565 Aerobactin VFC0272 Nutritional/Metabolic factor Aer is typically plasmid-encoded; the siderophore Aer has been distinguished as the most common siderophore secreted by hypervirulent K. pneumoniae Citrate-hydroxamate siderophore aerobactin is needed for successful infection by hypervirulent K. pneumoniae in pneumonic infections MISKKYTLWALNPLLLTMMAPAVAQQTDDETFVVSANRSNRTVAEMAQTTWVIENAELEQQIQGGKELKDALAQLIPGLDVSSRSRTNYGMNVRGRPLVVLVDGVRLNSSRTDSRQLDSIDPFNIDRIEVISGATSLYGGGSTGGLINIVTKKGQPETIMEFEAGTKSGFSSSKDHDERIAGAVSGGNEHISGRLSVAYQKFGGWFDGNGDATLLDNTQTGLQYSDRLDIMGTGTLNIDESRQLQLITQYYKSQGDDDYGLNLGKGFSAIRGTSTPFVSNGLNSDRIPGTERHLISLQYSDSAFLGQELVGQVYYRDESLRFYPFPTVNANKQVTAFSSSQQDTDQYGMKLTLNSKPMDGWQITWGLDADHERFTSNQMFFDLAQASASGGLNNKKIYTTGRYPSYDITNLAAFLQSGYDINNLFTLNGGVRYQYTENKIDDFIGYAQQRQIAAGKATSADAIPGGSVDYDNFLFNAGLLMHITERQQAWLNFSQGVELPDPGKYYGRGIYGAAVNGHLPLTKSVNVSDSKLEGVKVDSYELGWRFTGNNLRTQIAAYYSISDKSVVANKDLTISVVDDKRRIYGVEGAVDYLIPDTDWSTGVNFNVLKTESKVNGTWQKYDVKTASPSKATAYIGWAPDPWSLRVQSTTSFDVSDAQGYKVDGYTTVDLLGSYQLPVGTLSFSIENLFDRDYTTVWGQRAPLYYSPGYGPASLYDYKGRGRTFGLNYSVLF Kraken2_NZ_CP102391.1 IMICODJL_53053 Prodigal:2.6 117221 117520 - VFG048998(gb|WP_011154608) 100.0 5.3499999999999995e-68 (rmpA2) regulator of mucoid phenotype RmpA2 VF0570 RmpA Regulator of mucoid phenotype A VFC0301 Regulation Highly associated with Hypervirulent K. pneumoniae Positively regulate the cps locus at the transcriptional level, resulting in the hypercapsule phenotype MEKYIYFMCNKDVTLVLTDDYYFYFGLKQLTGLPLVYITYEGSMDKPIVIKQKRNIRVLVDSRIFYSGKWDGYKMLRKTLNMISQWMWLDISGGGEVLS Kraken2_NZ_CP102392.1 IMICODJL_53259 Prodigal:2.6 88420 89805 + VFG034652(gb|WP_000074204) 72.3 7.28e-227 (ibeB) Cu(+)/Ag(+) efflux RND transporter outer membrane channel CusC VF0237 Ibes Invasion of brain endothelial cells VFC0083 Invasion IbeA is unique to E. coli K1. The ibeB and ibeC are found to have K12 homologues p77211 and yijP respectively. IbeA and IbeB encode outer membrane proteins with three and two transmembrane domains, respectively; IbeC has a signal peptide-like sequence and five or six transmembrane segments at its N terminus Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction Unknown; the roles of Ibe proteins in E. coli K1 invasion of BMECs were verified by deletion and complementation experiments MFKLKLLSISTIFILAGCVSLAPEYQRPPAPVPQQFSLSKNSLTPAVNSYQDTGWRNFFVDPQVSRLIGEALTNNRDLRMAALKVEEARAQFNVTDADRYPQLNASSGITYSGGLKGDKPTTQEYDAGLELSYELDFFGKLKNMSEADRQNYFASEEARRAVHILLVSSVSQSYFSQQLAYEQLRIARETLKNYEQSYAFVEQQLVTGSTNVLALEQARGQIESTRAEIAKREGDLAQANNALQLVLGTYRALPSEKGMKGGEIAPVKLPPNLSSQILLQRPDIMEAEYQLKAADANIGAARAAFFPSITLTSGLSASSTELSSLFTSGSGMWNFIPKIEIPIFNAGRNKANLKLAEIRQQQSVVNYEQKIQSAFKDVSDTLALRDSLSQQLESQQRYLDSLQITLQRARGLYASGAVSYIEVLDAERSLFATQQTILDLTYSRQVNEINLFTALGGGWVE