Plasmid_ID Protein_ID Orf Prediction Source Start End Strand Product Cut_Off HSP identifier Best_Hit_ARO Best_Identities ARO Drug Class Resistance Mechanism AMR Gene Family Antibiotic Sequence SNPs_in_Best_Hit_ARO Other_SNPs TPA_BK008853.1 DAA64629.1 tpg 1619 1939 - putative partition protein Loose gnl|BL_ORD_ID|2220|hsp_num:0 pexA 36.36 3004666 phenicol antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump chloramphenicol; florfenicol MITDIDSIGIVTPVAFKEMLATGNVESASIQVSEKGLIIVLQLGASTRILGRSRGGARCFHSVDGAASVLLQHGIYQFNVDVEGWLPRTLTRNKGRSLLGKASDDL TPA_BK008853.1 DAA64630.1 tpg 2029 2271 - hypothetical protein Loose gnl|BL_ORD_ID|1457|hsp_num:0 mecB 26.0 3003440 penam antibiotic target replacement methicillin resistant PBP2 methicillin MSGKKIQIGAKPTNTAAATVAADDWVQNRDTAPIEKEPMKRLTIDIPESLHRAIKMHCVESGTSIADEVRALLLQKFVNQ TPA_BK008853.1 DAA64631.1 tpg 2268 2897 - partition protein Loose gnl|BL_ORD_ID|2583|hsp_num:0 OXA-664 28.57 3004479 penam antibiotic inactivation OXA beta-lactamase oxacillin MIIGVLNQKGGVGKTTLSVNIAAALAHSGARVLLIDADPQGSSLDWSAAREGDPIFSVVGLPRASVHKEIGQVGQGYDHIIIDGPPRVTDLARSAIMASDLVLIPVQPSPYDVWAADEVVKLIQEATVYKENLKSAFVVNRKIANTAIGRDVGEALAAYEMPILTSTVTQRVIYAEAAAQGKAVFEIDTAGPAAAEIAALVAEILEFAK TPA_BK008853.1 DAA64632.1 tpg 2993 3592 - gene transfer-related protein Loose gnl|BL_ORD_ID|78|hsp_num:0 gadX 31.71 3000508 macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; cloxacillin; oxacillin; norfloxacin MNKNTTTGLLLGYARVSTDDQDLTNQRAELQAAGCTKLFSEKFTGTQRNRPELARLLDHLRPGDVVTVTRLDRLARSTRDLLDIAEQLQTKGAGLRSLAEPWADTTTPAGRMVLTVFAGIAEFERSLIIDRTRQGREAAKARGVKFGPRPTLTETQITHARELIDQEGYSVREVAAILGVHRSTLYRAIERSESTESIK TPA_BK008853.1 DAA64633.1 tpg 3782 4075 - hypothetical protein Loose gnl|BL_ORD_ID|1915|hsp_num:0 vgaC 26.67 3002831 lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; pleuromutilin antibiotic antibiotic target protection vga-type ABC-F protein lincomycin; clindamycin; virginiamycin M1; tiamulin; valnemulin MKIRNVFCSLVVAFAVVSVSQAATATDLDVVHTAYEAYEGAAKALERSIDVVHSKLNTAGLTPEEMQKLQLQLDALKAQHDVALGRVMVEAAKKQQI TPA_BK008853.1 DAA64634.1 tpg 4176 5354 - putative peptidase Loose gnl|BL_ORD_ID|1083|hsp_num:0 QnrB22 31.58 3002737 fluoroquinolone antibiotic antibiotic target protection quinolone resistance protein (qnr) ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; nalidixic acid; norfloxacin; sparfloxacin MLQPPALEKFFKFPLHIARQFLSLLCHKRSECRVILVNDLIEKGLLGSVALVTTSIPIPAGRPGRHMRHVPRPCNTVFTYSLSLSGKFFYPQPKCLPLLDIASQCPSLLASYALGTTAANARALDSTEERIQDYRREQRILSDNSISGQSVQRGTLPPDTRPYLAPDWPTLAENTMPSVIALSAIEQPYGFAENSPAWLIPGVQQNAATAALTHYRAWQKGWAKQDAKRQHQTICGGFVIEGNRVLTAAHCVDRQEALRIRTAGGEWRAAHVVGADVTQDVALLEFEGDPLPPIKVANTLPRPGQDVMAIGSPSGYGFAVGVGIVAWHGLDAKMLSPNDFMLVTASVVGGNSGGVVVNTHGEAVSLVSYGSGSYTQTVPIDRALTVAGQLAK TPA_BK008853.1 DAA64636.1 tpg 6672 7556 + type IV secretory pathway protein VirD2 components Loose gnl|BL_ORD_ID|2170|hsp_num:0 FIM-1 38.3 3004786 carbapenem; cephalosporin antibiotic inactivation FIM beta-lactamase MLRSQRRGRDPPCWLSEKEPLVGKRRVNFQRCWLPVSRIGLHRRGVERVNCGPKLLDLGEKGVYSSYTCRVPGGDYEGYVDAHVRRLEALRRAGIVERIDADQWRIPDDLVSRAAAHDAGRDSQASVRVLSPVDLNKQIGSDGATWLDRRLIHGETADLAPTGFGQQVREAMDQRREHHIEQGDATRSRDSRVFYRRNLLAILREREVAGVGSDMALSKGLPFRAATDGESVSGKFTGTVHLSSGKFAVVEKSHEFTLVPWRPIIDRQLGREVMGIVQGGSVSWQLGRQRGLER TPA_BK008853.1 DAA64637.1 tpg 7773 8987 + florfenicol exporter Strict gnl|BL_ORD_ID|2308|hsp_num:0 floR 99.01 3002705 phenicol antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump chloramphenicol; florfenicol MTTTRPAWAYTLPAALLLMAPFDILASLAMDIYLPVVPAMPGILNTTPAMIQLTLSLYMVMLGVGQVIFGPLSDRIGRRPILLAGATAFVIASLGAAWSSTAPAFVAFRLLQAVGASAMLVATFATVRDVYANRPEGVVIYGLFSSMLAFVPALGPIAGVLIGEFLGWQAIFITLAILAMLALLNAGFRWHETRPLDQVKTRRSVLPIFASPAFWVYTVGFSAGMGTYFVFFSTAPRVLIGQAEYSEIGFSFAFATVALVMIVTTRFAKSFVARWGIAGCVARGMALLVCGAVLLGIGELYGSPSFLTFILPMWVVAVGIVFTVSVTANGALAEFDDIAGSAVAFYFCVQSLIVSIVGTLAVALLNGDTAWPVICYATAMAVLVSLGLVLLRPRGAATEKSPVV TPA_BK008853.1 DAA64638.1 tpg 9015 9320 + putative transcriptional regulator protein Loose gnl|BL_ORD_ID|1903|hsp_num:0 NmcR 40.96 3003665 carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation NmcA beta-lactamase cefoxitin; cefazolin; ampicillin MRRTNHRNLVNVGILSGRIPLISLVQFIAVAEHLNFRHAAKALGISQSSVSARVKALEDNLGVLLFERHARGVRLTDAGRHFMERVTAGVDQLDHAVKTAE TPA_BK008853.1 DAA64639.1 tpg 9237 9638 - putative truncated peptidase Loose gnl|BL_ORD_ID|2777|hsp_num:0 LpsA 19.39 3005052 peptide antibiotic reduced permeability to antibiotic Intrinsic peptide antibiotic resistant Lps polymyxin B; defensin MLQPPALEKFFKFPLHIARQFLSLLCHKRSECRVILVNDLIEKGLLGSVALVTTSIPIPAGRPGRHMRHVPRPCNTVFTYSLSLSGKFFYPQPKCLPLLDIASQCPSLRGLHCVIELIDTRRDTLHEVPACVC TPA_BK008853.1 DAA64640.1 tpg 9432 9893 + putative transposase Loose gnl|BL_ORD_ID|874|hsp_num:0 APH(3')-IIb 35.56 3002645 aminoglycoside antibiotic antibiotic inactivation APH(3') neomycin; ribostamycin; butirosin; kanamycin A; gentamicin B; paromomycin; gentamicin MPHVAARTASRDRDTGRYQSHRPEQTLLYQIVDEYYPAFAALMAEQGKELPGYVQREFEEFLQCGRLEHGFLRVRCESCHAEHLVAFSCKRRGFCPSCGARRMAESAALLVDEVLPEQPMRQWVLSFPFQLRFLFGVVCGTCNPQRRCGYTAI TPA_BK008853.1 DAA64641.1 tpg 10036 10659 - tetracycline repressor protein Loose gnl|BL_ORD_ID|442|hsp_num:0 tetR 52.22 3003479 tetracycline antibiotic antibiotic target alteration; antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MTKLDRETVIQAALELLNEVGVDNLTTRKLAERLKVQQPALYWHFRNKRALLDALSEAMLEKNHTRTVPQTGEDWRVFLKENALSFRSALLSYRDGARIHAGTRPTSAQYERVEKQIRFLCESGFEQPDAVRALVIVSHYTTGSVSEQQAALEDSSERKQASKEAPAQPSQFLSHAFDTFDAEGADFAFEYGLDALISGLEMKKATK TPA_BK008853.1 DAA64642.1 tpg 10742 11917 + tetracycline resistance efflux protein Perfect gnl|BL_ORD_ID|440|hsp_num:0 tet(Y) 100.0 3000182 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MSKSLITALIVVALDAIGLGLIMPVVPALLNEFVPAEQTAFHYGVFLSLYAFMQVFCAPVLGRLSDRYGRRIILLVSFLGATIDYSIMAAAPVLWVLYIGRIISGVTGATGAIAASIIADTTKQEERARWFGFMGACFGAGMIAGPAIGGVLGDISVHAPFVAGALLNAIAFCLVAFLLPKTPSQPPEGQPAKINLFEGFRFNFAVQGLASFFALFFLMQLIGQAPAALWVIYGEQRLNWDIGTAGVSLAVFGAAHTFVQAVLTGTLSKRLGDRGVLLLGMGADMCGFLLLAFITQSWMVLPAIFMLATGGIGMPALQAIISGLVCDEKQGALQGTLTGLTNITSIIGPVGFTTLYGLTAGQWDGWVWLVAASLYLIAIPLLRQSASLLRS TPA_BK008853.1 DAA64643.1 tpg 12367 13203 - streptomycin phosphotransferase B Strict gnl|BL_ORD_ID|949|hsp_num:0 APH(6)-Id 99.64 3002660 aminoglycoside antibiotic antibiotic inactivation APH(6) streptomycin MFMPPVFPAHWHVSQPVLIADTFSSLVWKVSLPDGTPAIVKGLKPIEDIADELRGADYLVWRNGRGAVRLLGRENNLMLLEYAGERMLSHIVAEHGDYQATEIAAELMAKLYAASEEPLPSALLPIRDRFAALFQRARDDQNAGCQTDYVHAAIIADQMMSNASELRGLHGDLHHENIMFSSRGWLVIDPVGLVGEVGFGAANMFYDPADRDDLCLDPRRIAQMADAFSRALDVDPRRLLDQAYAYGCLSAAWNADGEEEQRDLAIAAAIKQVRQTSY TPA_BK008853.1 DAA64644.1 tpg 13203 14006 - streptomycin phosphotransferase A Strict gnl|BL_ORD_ID|1688|hsp_num:0 APH(3'')-Ib 99.63 3002639 aminoglycoside antibiotic antibiotic inactivation APH(3'') streptomycin MNRTNIFFGESHSDWLPVRGGESGDFVFRRGDGHAFAKIAPASRRGELAGERDRLIWLKGRGVACPEVINWQEEQEGACLVITAIPGVPAADLSGADLLKAWPSMGQQLGAVHSLSVDQCPFERRLSRMFGRAVDVVSRNAVNPDFLPDEDKSTPQLDLLARVERELPVRLDQERTDMVVCHGDPCMPNFMVDPKTLQCTGLIDLGRLGTADRYADLALMIANAEENWAAPDEAERAFAVLFNVLGIEAPDRERLAFYLRLDPLTWG TPA_BK008853.1 DAA64645.1 tpg 14067 14882 - dihydropteroate synthase type II Perfect gnl|BL_ORD_ID|873|hsp_num:0 sul2 100.0 3000412 sulfonamide antibiotic antibiotic target replacement sulfonamide resistant sul sulfadiazine; sulfadimidine; sulfadoxine; sulfamethoxazole; sulfisoxazole; sulfacetamide; mafenide; sulfasalazine; sulfamethizole MNKSLIIFGIVNITSDSFSDGGRYLAPDAAIAQARKLMAEGADVIDLGPASSNPDAAPVSSDTEIARIAPVLDALKADGIPVSLDSYQPATQAYALSRGVAYLNDIRGFPDAAFYPQLAKSSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIAALTGAGIKRNRLVLDPGMGFFLGAAPETSLSVLARFDELRLRFDLPVLLSVSRKSFLRALTGRGPGDVGAATLAAELAAAAGGADFIRTHEPRPLRDGLAVLAALKETARIR TPA_BK008853.1 DAA64647.1 tpg 15531 15869 - hypothetical protein Loose gnl|BL_ORD_ID|446|hsp_num:0 macB 28.57 3000535 macrolide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump erythromycin MTVEPTNEELAKSYTNKIEQAQERRQEKNQERLERHGEAAAIAAQDPGFSNFSSQTVEIDGITSQQSKSLAKELNSDNEKGDSVKQAKAMEMAKRFREKAAQDRQQSRVFSR TPA_BK008853.1 DAA64648.1 tpg 15893 19216 - conjugative protein Loose gnl|BL_ORD_ID|1211|hsp_num:0 mdtC 42.31 3000794 aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump novobiocin MAIYHFTTHTMSRANGHSAVAAAAYRSASKLVDERTGEVCDFTRKGGVISAEIVTPEGVPVPARSDLWNAAEAAEKRKDSRVAREWLAALPHELDDTDRKALAHEMAQAIADRYGVAVDVCIHAPDQEGDERNYHVHMLATTRVIEQDGSLGKKAVIELANKDRKKAGIEGTSQGDITELRAQWADLANRSLERAGVTARIDHRSYVDQGIELTPTKHVGRDAMAMERRGMEADRVDIHNLDRQKQAEEITARPEIIIEKITATQAVFTKRDIAKELNRYIDDADQFQELLVKLEQSPLLVEMEPEKGRHLAKFSTQEMIQTERAMVDGAERMAGSGKHGVSSAITNAVIGGVSTLSGEQQNAVRHVLDSGSLSVIIGDAGTGKSFSMKVAREAWQAQGFNVRGAALAGKAADELQAGSGIDSRTLASLEFAWKNGKDKLSSRDVLVIDEAGMIGSRQLGRVLKAAEQAGAKVVLLGDDKQLAAIEAGAAFRGVVQHVGAAEITEVRRQKEAWAREAGQQFARGSVETGLAAYAERGHVKVHNTREEAQEALAAAYVSDQGKGSQIVLTHSNKDVQALNEAIREARKERGELRGSARFESEKGGREFAPGDRIVFLKNDKGLDVKNGTLGTVEQAEDGSLSVRLDSGESRQVRAESYAAVDHGYAVTVHKAQGVTVDRAYMLATPGMDRSLTYVGMTRHREEATLFAGADDFADKRAGRLVEHGAAPYENQPGNRQSYFATLENDKGEKRTIWGVDLQRAIEDSGAKRGERISLEHGGSQTVTLPDGQLAERNTWKVKSANELAAGNLVKVLGRERPKESTLDFADRRGFDGENVLQRWLNRGRTKAAEIAGKVRDALGISTKDIAGKPQPVIEPKEQPQQQPKQVQPVQQPEDEKAKRAQEIAEKFRAKVAQERGEQQAQKVEQPQADNLAGFRASVERAEAAGGGLALDVAQAQLAVAKEYQAAGKDPKHHIAAILQEGQTKAFSSLQSGSEAKAEPVRGEVVQVSEKDRKLAEANAKMEINKFKGLAVRRQGGFAGYSDRNPSAWLAVPEEMRGRIEQYNALPKERQAAALEKMHRELVDRYTRDPKAAHRDRNQGRERSGFSR TPA_BK008853.1 DAA64649.1 tpg 19409 19663 + conjugative protein Loose gnl|BL_ORD_ID|3601|hsp_num:0 IMI-5 43.48 3001862 carbapenem antibiotic inactivation IMI beta-lactamase MARRKLSERKASKLADLERIKAEIQEIERKAAERIGKLAINAGLGDLDISDADLRKEFEAIASKFSPKSESQQPAQSSTAFSQN TPA_BK008853.1 DAA64650.1 tpg 19686 19904 + conjugative protein Loose gnl|BL_ORD_ID|4669|hsp_num:0 vanT gene in vanC cluster 38.46 3002970 glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanT vancomycin MNARREDTRNKIQLGGLVIKAGLDEYPTAVILGAMHLAANALKGPKSYEAQERFRAAGDALFLSGKDGGNRN TPA_BK008853.1 DAA64651.1 tpg 19939 22452 + conjugative protein Loose gnl|BL_ORD_ID|1111|hsp_num:0 novA 39.53 3002522 aminocoumarin antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump novobiocin MIDKFEQTAIRIWVTLVAVFVWSFLFSLNANASIFPECNPAAEAQSFQFSENIDSWVSRSCEAQSLAVKKLEPKLETLDKSQQELTIATNAGDWQQYREKWAEVLPELKNLEAAAIEHKSASGAASLVSLYRADMGYFLQNVGLQPAANLDDFTARIMSGLDGTNPSGAATAGVNIVQQSVTRGIELTKGIVQLEKNKVLAEYRSDIEQRGNERMAKLEGSTFDGYVGGFGERIGGIMTAWFFYLILICFFGAYIAYKRRQNPVLVALALGLSFLPTSVVMMLLYIFIPQIPGFAMLAITVGGTVATYLNAGKVFNWLANSIGSQTSTARRLRTIGGVIDNLRGVSAPVTKMGATAVQPDNTALDEAGSHGSARWGTVSELQEKGHLVPPSKPAGFALGRVSEAPAGLDARFRFTGHVTTVAPTGSGKGIGAVIPNLLDYPGSALVLDVKGENAAVTARARRALGHAVYSIDPFAVNSEPGAAFNVLDRLDVWSPDCVSESAILADALVIGEAKGDGAHFEESAKNFLQGLMLYVASLEDQDTRNLGELRRLLTVDEDEFYSVLGMMASDEMAAFGIPARAANTLMGMADKERGSVLSTARRHTAFLDDPRIAAALSKSDFDLSEIKAKAMTVYLVMPANRIAPNARFLRLFISTVIASVTSSNEQPAHRVAFILDEFGQLGYMKQIEDAVSLLRGYGLAFWVFIQDLSQLKGTYPKWQTFLANSAKTFFGTDDFDTAKYISDSLGKATIEFETENTGKNSGSGFSGGGGSMNRGSSTGKSQQFAGRELLTPDEVMRLGPERPIILVQGERPYLVERLNYLADKEYAGLFDPNPYHS TPA_BK008853.1 DAA64652.1 tpg 22463 22756 + hypothetical protein Loose gnl|BL_ORD_ID|2226|hsp_num:0 BahA 28.75 3003984 peptide antibiotic antibiotic inactivation Bah amidohydrolase bacitracin MLFLLGLAISMAILGWLLQRLFPAAFAAGLVVLAPLWLVLGWLHDVLRLPLSFLRPVGAALARVLGFIVVVPMLPFIFTWSLLSALRRRKQPPGKDE TPA_BK008853.1 DAA64626.1 tpg 22969 23967 - involved in transcriptional regulation Loose gnl|BL_ORD_ID|2489|hsp_num:0 tet(W/N/W) 25.93 3004442 tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein tetracycline; minocycline; chlortetracycline MLYNTRYNILHDTKPEETTMQAPLSNERIHEVADQLAAAGQRPTLAAVREALGGGSFTTISEAMKLWRKQASEQEQLQPLVEALPDVLQQAALTTAAAVWREAQALAASRLEAERQALAQAQETLEAEQAETVELVALLERDLELSRTELADVVAKAADAEVVSNARITKNANELDSLRAELTQAVLRAERAEAKAVEIERRAVDLRAELDRAHQDADKTAAALAEQKTVADKYRAAVEHEKAKNVELDSASKRLLEQYQQAAADLVKATEKADQAAVEIAELKTVQQAAQEASIQAAAANARLETVEKQAADLLDRLTRANTVDKKKGSKE TPA_BK008853.1 DAA64627.1 tpg 24255 24566 - hypothetical protein Loose gnl|BL_ORD_ID|407|hsp_num:0 LRA-5 34.21 3002483 cephalosporin; penam antibiotic inactivation class A LRA beta-lactamase MRKASRKSFSPELLQQLREMSVTAALDAMGLYWKRDPDYVPVKDKNTVRVNVALGGGVVELLATGPKWYDTRAEKGGGGAVDLAMYLLRLDFVTAVKRVQANV TPA_BK010450.1 DAC74105.1 tpg 1319 1687 - putative DNA-binding protein Loose gnl|BL_ORD_ID|1209|hsp_num:0 adeA 24.77 3000774 glycylcycline; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump tigecycline; tetracycline MIGLSNKKQIEELKFQNTRLQIKNSKLEEEIRILKTENQRQKDLLSEWEKSYKKSIRDVANFKNELKKYNPNLKPRSKQISKSDIKRIKELFEMNEYTYREISQITKWSICTISKVINGFYD TPA_BK010450.1 DAC74106.1 tpg 3203 5161 - tetracycline ribosomal protection protein Strict gnl|BL_ORD_ID|736|hsp_num:0 tetB(P) 96.47 3000195 tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein tetracycline; doxycycline; minocycline; chlortetracycline; demeclocycline; oxytetracycline MKKIINIGIVAHVDAGKTTITENLLYYSGAIKSVGRVDLGNTQTDSMELERRRGITIKSSTISFNWNNVKVNIVDTPGHVDFISEVERSLSGLDGAILVISGVEGIQSQTRILFDTLKELNIPTIIFVNKLDRIGANFNKVFEEIKKNMSNKVVRLQEVYDAGSKAVYIKNLFDTCIINDDAINVLSDLDEAFLERYIGGIEPDKEEIQEKLSLYAREGSLYPVFCGAAAIGLGVEDLLDGICSYFSFAGDDCESDLSGVVFKIERTSKNEKKVYVRLFGGKISVRDKIQVPNKEIAEKVKKINRLENGVIIEAQRIEAGDIGILYGLTSFQVGDVIGISNNKIKNISIAKPALKTTISAIDKEKNPELFKALTLLAEEDPLLELEMNDMDKEIYVNLFGEVQMEILSSMLDDLYGIKVEFSNIETIYKETPKGFGASIMHMQEDLNPFWATVGLEIEPAGRGEGLRYISNVSVGSLPKSFQNAIEEAVIKTSKQGLFGWEVTDVKVTLSCGEFFSPASTPADFRNVTPMVFMEALYKAQTVLLEPLHEFELRIPQNALSKAVWDLETMRATFDNPIVIGDEFSIKGLIPVENSKEYKMKIASYTEGRGMFVTKFYGYKEVSAGFAKARQKTTYDPLNKKEYLLHKLNAIRD TPA_BK010450.1 DAC74107.1 tpg 5145 6407 - tetracycline efflux protein Loose gnl|BL_ORD_ID|467|hsp_num:0 tetA(P) 89.52 3000180 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MVNKLSAYKTYLLFSAITAMCFSLVATVMIVYHIETVHLNPLQLILVGTTLEVACFIFEIPTGIVADVYSRKLSIVIGAVLTGVGFILEGSISSFVFILAAQIVWGLGSTFISGSVEAWIAEEEKDKDLDEIYIKGAQVGQIGSVIGIVLSTVIANFSVRLPIIVSGVLFIILALFLWLYMPENNFKPSAPEDLNTFKKMGYTFKSGLKFIKSKSIIMILLSVTLFYGLSSEGYDRLSNAHFLQDTMLPKLGNLKPVTWFGIFGIAGMILSAIVMHFMEKKLKDDDKNQNGKLLLCINIFYISFMFIFAITKSFNLMLIAYLATNTFRTINEPIFSAWLNGHIDDKARATVLSINGQINSLGQILGGPIIGIIATNISVSMGIACTSLLVTPVLVLYIVAMIMDKKVVDRVGGIDYEENN TPA_BK010451.1 DAC74108.1 tpg 2064 3326 + tetracycline efflux protein Loose gnl|BL_ORD_ID|467|hsp_num:0 tetA(P) 89.52 3000180 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MVNKLSAYKTYLLFSAITAMCFSLVATVMIVYHIETVHLNPLQLILVGTTLEVACFIFEIPTGIVADVYSRKLSIVIGAVLTGVGFILEGSISSFVFILAAQIVWGLGSTFISGSVEAWIAEEEKDKDLDEIYIKGAQVGQIGSVIGIVLSTVIANFSVRLPIIVSGVLFIILALFLWLYMPENNFKPSAPEDLNTFKKMGYTFKSGLKFIKSKSIIMILLSVTLFYGLSSEGYDRLSNAHFLQDTMLPKLGNLKPVTWFGIFGIAGMILSAIVMHFMEKKLKDDDKNQNGKLLLCINIFYISFMFIFAITKSFNLMLIAYLATNTFRTINEPIFSAWLNGHIDDKARATVLSINGQINSLGQILGGPIIGIIATNISVSMGIACTSLLVTPVLVLYIVAMIMDKKVVDRVGGIDYEENN TPA_BK010451.1 DAC74109.1 tpg 3310 5268 + tetracycline ribosomal protection protein Strict gnl|BL_ORD_ID|736|hsp_num:0 tetB(P) 96.47 3000195 tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein tetracycline; doxycycline; minocycline; chlortetracycline; demeclocycline; oxytetracycline MKKIINIGIVAHVDAGKTTITENLLYYSGAIKSVGRVDLGNTQTDSMELERRRGITIKSSTISFNWNNVKVNIVDTPGHVDFISEVERSLSGLDGAILVISGVEGIQSQTRILFDTLKELNIPTIIFVNKLDRIGANFNKVFEEIKKNMSNKVVRLQEVYDAGSKAVYIKNLFDTCIINDDAINVLSDLDEAFLERYIGGIEPDKEEIQEKLSLYAREGSLYPVFCGAAAIGLGVEDLLDGICSYFSFAGDDCESDLSGVVFKIERTSKNEKKVYVRLFGGKISVRDKIQVPNKEIAEKVKKINRLENGVIIEAQRIEAGDIGILYGLTSFQVGDVIGISNNKIKNISIAKPALKTTISAIDKEKNPELFKALTLLAEEDPLLELEMNDMDKEIYVNLFGEVQMEILSSMLDDLYGIKVEFSNIETIYKETPKGFGASIMHMQEDLNPFWATVGLEIEPAGRGEGLRYISNVSVGSLPKSFQNAIEEAVIKTSKQGLFGWEVTDVKVTLSCGEFFSPASTPADFRNVTPMVFMEALYKAQTVLLEPLHEFELRIPQNALSKAVWDLETMRATFDNPIVIGDEFSIKGLIPVENSKEYKMKIASYTEGRGMFVTKFYGYKEVSAGFAKARQKTTYDPLNKKEYLLHKLNAIRD TPA_BK010451.1 DAC74111.1 tpg 8505 9653 - MobA-like relaxase/mobilisation protein Loose gnl|BL_ORD_ID|3520|hsp_num:0 EC-8 30.0 3006881 cephalosporin antibiotic inactivation EC beta-lactamase MAIYHLSTKIISRSKGKSSIASSAYRSGEKLYNKRDGLIHDYTKRKDVIYKEIFKPSNAPNWVLDREQLWNEVEQIEKSKNSQLAREIDIALPIELNEKERIELLRKYVIDNFSSKGMVADVVIHDKKDGNPHSHIMLTMRPFEENGEWGAKAKKEYILDKNGNKTYSKNGNAKSRKIETTNWNKKETLENWRAQWSIYANKALEKANRKERIDHRSYKDRGIDRLPTRHEGPTVRAMEKKGIKTEIGDINRKIQEENQKIDIIENQIKLYEEMKELENERTKDNGTRNRNIETKEGANELTEGIGGFGDRDRLEIRKRTEELKKITRDKRDQDRADREELRKYNERIERRKMEIARQSYKKQESDRRIKQNNRSIETGLEL TPA_BK010830.1 DAC79475.1 tpg 834 1172 - uncharacterized protein Loose gnl|BL_ORD_ID|3823|hsp_num:0 OXA-572 39.39 3005794 cephalosporin; penam antibiotic inactivation OXA beta-lactamase; OXA-22-like beta-lactamase oxacillin MASPTGDDLDGVNEAKKYPDGTVVRVFCMRTNRDTYPSGWAYKLHYGATEPDPPHTLDDGTIRRYDNSHEDTKGHELHVAPDPDPNIIEFPGMVELWERFWSEIPKSQFEVT TPA_BK010830.1 DAC79476.1 tpg 1896 3044 + spurious ORF Loose gnl|BL_ORD_ID|438|hsp_num:0 MexA 32.81 3000377 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole MRELVGRVEAVAFLGERQERVRGHCRLIADLAVQFQLHEDVHKSPAVVQHAGEREVEVPEPVVGRLRLCEERLQFLEAVLDTPTPLVSGHQSPNLVFHLLLVGGIDIHPREIRLKGQGRRFDPRWLVDLLLFGDLIEKVAQRRVAVAVLRERRRVADVLEVLDEFLSDRHIRPVVVFVLAFPLALREVNRLPRRTVVQSLLLDDIEVFVFTGKLSDLVFVVAAGPDDTGVEVVDVVRLADVFDAVRGELAVHHHQIESRDDVGCAFEEIVYDIRSLSTTNNRDGIKDQRDVVADEFDDCPLEERPVIALVAENPRLLILSTTIAFHVAAPRVALREVDGRHLLAPHLVLRFRSRHKRPASLPEHRPDALNAERLRLQPVGVA TPA_BK010830.1 DAC79477.1 tpg 1905 3719 - ISH7-type transposase ISH7 Loose gnl|BL_ORD_ID|2479|hsp_num:0 ACI-1 22.98 3004359 cephalosporin; penam; penem antibiotic inactivation ACI beta-lactamase penicillin; ceftazidime; amoxicillin; cefotaxime; ticarcillin MTFREMVDGALKTYPREQQVRHNRSVTLEDLVTEVPVTYLRFYDEYDHDQGHPKPWGAVFRAHVLRCVKGWKNATALHRYLKQQPFLCTQLGFKDIPDQSTLYRAWDDRLEDVHDAVRDAAEVVVDIARYHDIPAPEPEFLPDQPTDTVTNSKSKDTLAREKAREVWKGAKPIVEDAFHLDRSDNASIPEGAFWEQQSYLGMRTDMHPNDGAQSFAADSTRRKTPSGDSHRLQTKTLGVERIRTMLRETGRTLVARAKSKDKMGRKQMTAIDFTKGNPWSGHVERDSSGQNQEPWILGYKGDDGPFFQWAVIKLVGHDVPLILDAVPVVRGRKRADIVDDLLEGATDIVPGLDLVMMDREFAPDGVKDVCETHDVHYLNPGVVRSSSDHEHQIAKLASEDKDFDVIKQERLDDGPTRKAVYLPKREWEREDEDNDGTDVTIRQELIEDFKDVGNTTPLSEDRDGDSPLSNLLNEVAEEEEIDEPARVEAPTLPFETNLPWVDVDPADQQEMKHQIGRLMARYKRRWGIENGFKKLKTFLAETQSPDHRFRYFNFAFACVLYNCWRLVDILVQLELYGEIGDQPAVSSNSFLTFAKKSYGLDPPD TPA_BK010830.1 DAC79478.1 tpg 4096 4218 + uncharacterized protein Loose gnl|BL_ORD_ID|1764|hsp_num:0 BEL-3 34.48 3002387 monobactam; cephalosporin; penam antibiotic inactivation BEL beta-lactamase MEQIGSNMESMYSILSANTDTFERDATQEVNSKQDSPVIL TPA_BK010830.1 DAC79479.1 tpg 4215 4610 + uncharacterized protein Loose gnl|BL_ORD_ID|35|hsp_num:0 golS 35.9 3000504 monobactam; carbapenem; cephalosporin; cephamycin; penam; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump chloramphenicol MSELPENIQRQKRNGYLMLVGAVFTFGVTAATVQYYELSPISYLGGLVPAGILVFFGYRAVSAGRERKALGDERTQQLYGKVGINSFWILMSVIMVDMAFSIFPEDSATSIYVWIGLACYGLYFVYYRYVE TPA_BK010830.1 DAC79480.1 tpg 4614 4811 + cro/C1 family transcription regulator Loose gnl|BL_ORD_ID|4730|hsp_num:0 vanU gene in vanG cluster 26.53 3004253 glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanU vancomycin MENELKVYRAKHDLTQEDLAKEVGVTRQTINALEAERYDPSLELAFKLAIYFDCSIEDIFSYDSD TPA_BK010830.1 DAC79482.1 tpg 7861 8661 - integrase family protein Loose gnl|BL_ORD_ID|3533|hsp_num:0 FRI-10 25.37 3006227 penam antibiotic inactivation FRI beta-lactamase MRRQAVPLHKKRHYHILNAIHEHPNDDKAMSVHLGIGTGMRNNTIGHVYKDWFFYDSDGNLYIQIPGSDKCRKGNGDGTCGHCEDGGQYNPKTEAGDGRIILIPNSWHNHANEGEEEYFGLKDHVEAYFALDGKNAPDNVRYGKDMIQGNGVSKGPLNKWVRDVAAKSAIQPQLRMKRLEQAGVPNGNGEDEPKKIKDFGHDDEGNKIPDMIFHDLRACYCTQLMRNEVPPHKAINKTGHADPDSLKPYVMFAANEIDAKEEQQWY TPA_BK010830.1 DAC79483.1 tpg 9402 12431 + plasmid replication protein RepH Loose gnl|BL_ORD_ID|2055|hsp_num:0 Clostridium perfringens mprF 42.42 3003773 peptide antibiotic antibiotic target alteration defensin resistant mprF defensin MHTPNQQQGIRKIVPGGTLSTAGITITEVTPRVTEWIPDLLEELLPRSIQSVRKFIRQEDPEVLTHARYNTVYRRLQEETLRFDHQEWCSTTDIWSDAEAEAVEYVESLVEFAVKYSDVDEDDLDELSEYHQQRCKSLKQTLTTISTGRGPLNAGLEALAKGPVRLHDELDDAPQPITLVLDGELWSKLDDRGTGIRALAAIAVLGSTFDVRLVISPALDAAIERRYPDWYDSHLRLTETRETSSVESAGGDGQPSAEQLEEAWEAIQNLPEESGRLRLLRNLPIEGSRDYRDLKQDDEIDVQAGTVGRYILDLEELGLVDIDRRGQYNSASLTGLGQVAVEQYVTTDYRVIHPTQSTLETHLTPTPQPQASTVYPARSDTREGDQPGTAEDWIAATGSPSEGADYVQWLDGPSGVLDAWGMHQRYLAGRRDRGVTLVDDRIERFEDGRVSYLSCFDDDLFVATQWGGPLPTLGRIAGALLSDKALSKILTPSRLGNQFEEINDAVVEQLDREAGEIIRRGHQIGWFSEDEEDYDGWRERIGSVRSLCLQQVGELTNSDDVEARTELLRDLHGLVASATQLYYAAGVDVTINVRVPDTGMLISDERRLDDFLGFARYTIPKQSVYGIHSGYRMLLEDRPEKLKRRLPYEVDDADSTMHLTASWVFSGSTMIDLHDDIEDAIEMETNEIREAIANGQESAPVMEIPVQIGNSYSAIRNHVEDYASAKNYQVAHQEDIHEGKQDLERLVRLFLRVLGTEDRPHRACPHDVAEAMLHVAQSSRNYDFITVRDISYGLSNLPTKRLLPELPPTATKLLKTLLDADDPMGRSEIIDTADISESSYDRYINELAAWDIIEPREIEGHRRWEAHLEPWWTPQSDRDEPYADPDPDTGILYAEFPRDVASAVMCHLITHYDLPDLETAYLEGIQPGDDIKALFDDHDRLRRWRPFLWGAFADSDKLERGPSGTAASDSTVVRLGQSPGPDTAQSSFQDVSETATQRDRLSQPSPGLD TPA_BK010830.1 DAC79484.1 tpg 12847 14013 - ISH3-type transposase ISH3 Loose gnl|BL_ORD_ID|3042|hsp_num:0 OXA-653 39.53 3005342 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-24-like beta-lactamase oxacillin MSTTQQADGEIHEDQLLNFLVNALDEEVALTLAENAEIDAEDIYEVLVGACADGTSVSTLCEKSEDAPHENSVLYHLRTKFDLETLEQVGNALLQKDVLDVLPQQVEVVSDLHLRPYYGDEDGTDGLYHSQAKRGTTAFHAYATLYARVKNKRYTLAVRRLEDGDTASSVLAEFLGILDGLDLDVKAVFLDREFYDSKCLTLLQAHNHAYVMPIVRWGQTIKQELSEGWSRVIQHDMTAKLDGHSWTVEFLVYIDCTYQNGRCDEHGVARHGYAADAPFIESPRDARYHYAKRFGIEASYRLSEQSIATTSTQNPVVRLLYVVVSLLLQNVWRYLHWEYVATPRRGGRRLWKWSFKEFINMIQRAAWTALATRRAVPANRPPDDRFTR TPA_BK010830.1 DAC79485.1 tpg 14308 15582 + ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|2194|hsp_num:0 catII from Escherichia coli K-12 39.53 3004656 phenicol antibiotic antibiotic inactivation chloramphenicol acetyltransferase (CAT) chloramphenicol MRRLTTLFPSEFLEEHAEELGVVERDRKLQIPAFVWAFVFGFAAGESRTLAGFRRCYNSTADETISPGGFYQRLTPTLAEYLRDLVEHGLDEVAVPNAVDADIDRFRDVMIADGTVLRLHEFLSDQFEARHEEQAGAKLHLLHNATEQTIERLDTANEKTHDSTLFKTGPWLENRLVLFDLAYFKYRRFALIDENDGYFVSRLKQNANPLITRELREWRGRAIPLEGKQLRAVLDDLDRKYIDVEVEVEFKRGPYNGTRSLDTKRFRVVGVRDEDADDYHLYMTNLVRKEFFPADLAQIYRCRWEVELLFRELKTQYNLDEFNTSDEHVVKILLYAALLSLLVSRDLLDLVTEQADDELVFPTERWAATFRSHAQLFLHKLGEYLGYSPPPLLERLTEDAQKIHKQRPILQETLATATQPRCES TPA_BK010830.1 DAC79486.1 tpg 16107 16631 + spurious ORF Loose gnl|BL_ORD_ID|1787|hsp_num:0 MexB 38.46 3000378 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole MRVPAPELNGSSSSTELRRSVNSRMDSTRVRSPSRTIQLPTASVSPAHTRIQSIRVPSPRRSTATWSGVRLDATLSSRSRCEPVVFRLATAVIQHIPVGFPHYPSPLFSRDTTSNQSSRRSAVGEVVNASLCCRCAASHSSNRPYSVMVVMPAIAARRLIPIRGMSATVTITSA TPA_BK010830.1 DAC79487.1 tpg 16451 16705 - gas-vesicle-associated protein GvpM Loose gnl|BL_ORD_ID|2778|hsp_num:0 ArnT 72.73 3005053 peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase colistin A; colistin B MEPTKDETHAIVEFVDVLLRDGAVIQADVIVTVADIPLIGISLRAAIAGMTTMTEYGLFEEWDAAHRQQSEAFTTSPTADRRED TPA_BK010830.1 DAC79488.1 tpg 16705 17550 - gas-vesicle-associated protein GvpL Loose gnl|BL_ORD_ID|2077|hsp_num:0 AAC(3)-IIe 28.45 3004621 aminoglycoside antibiotic antibiotic inactivation AAC(3) dibekacin; sisomicin; netilmicin; tobramycin; 6'-N-ethylnetilmicin; 2'-N-ethylnetilmicin; gentamicin MTDHRPSPEEEQTTANEERTVSNGRYLYCVVDTTSSESATLSTTGVDDNPVYVVEADGVGAVVHDCETVYETEDLEQVKRWLVTHQQVVDAASDAFGTPLPMRFDTVLEGGDASIERWLEDHYEGFRDELASFAGVWEYRINLLWDSAPFEETIADRDDRLRELRQRQQQSGAGKKFLLEKQSDQRLQELKRERRTELADQLKEAITPVVNDLTEQDTNTPLQDEHSSIEKEQIVRFAVLADEDDETALGDRLDTIVEHEGVEIRFTGPWPPYTFAPDIGK TPA_BK010830.1 DAC79489.1 tpg 17547 17888 - gas-vesicle operon protein GvpK Loose gnl|BL_ORD_ID|1560|hsp_num:0 Erm(39) 33.93 3000602 macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase erythromycin; roxithromycin; lincomycin; telithromycin; clarithromycin; clindamycin; tylosin; spiramycin; azithromycin; dirithromycin; pristinamycin IA; quinupristin; virginiamycin M1; madumycin II; griseoviridin; dalfopristin; pristinamycin IB; virginiamycin S2; pristinamycin IC; vernamycin C; patricin A; patricin B; ostreogrycin B3; oleandomycin MELALDDDADDLQGGLTALVVTVVELLVEALEQEAVRRMESGSLSEDEIERLGRQLQALEDELERLKQQEDINAEVSEFREDLDHVIRDAIEQLSEHETPSGHGSPESQRDDV TPA_BK010830.1 DAC79490.1 tpg 17890 18234 - gas-vesicle-associated protein GvpJ Loose gnl|BL_ORD_ID|1625|hsp_num:0 QnrS7 30.77 3002796 fluoroquinolone antibiotic antibiotic target protection quinolone resistance protein (qnr) ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; nalidixic acid; norfloxacin; sparfloxacin MSDPKPTRSQGDLAEMLEMLLDKGVVVNADIAVSVGDTELLGIELRAAIASFETAAEYGLEFPTGTDMERVESAANISPDQSDPASETQSETESTNPLSDDSTPTASTSAEETK TPA_BK010830.1 DAC79491.1 tpg 18227 18661 - gas-vesicle operon protein GvpI Loose gnl|BL_ORD_ID|2732|hsp_num:0 OXA-476 27.78 3003633 penam antibiotic inactivation OXA beta-lactamase; OXA-63-like beta-lactamase oxacillin MSDKQQQKHKQKARQARVKAQINRDKARRNLLRQREKLARRRTRNRKQSEPRRDDSDGDDTDGETVKNPAAHSTMPPQKSNAENAVRNSHSTVPKTPKYSDVTARERLYGQRLHQKTAGGNSEASAPSDESASGSPTEDEVNDE TPA_BK010830.1 DAC79492.1 tpg 18658 19206 - gas-vesicle operon protein GvpH Loose gnl|BL_ORD_ID|409|hsp_num:0 mtrE 26.42 3000812 macrolide antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; penicillin; azithromycin MVPDENDDASDDQSSQLSGLLDQLHTLVEVLADIEEEGGHRHESGRIDRGNARIDYDYDVSIGLGRADGSSYDEEPSSNRSRSEQRSGQQRTTEDSIHVETRGGTSGDELVVVADLPGVTDDDVDVALDTDEQALTLRVDDDVVERVVLDRPDVAITDMTLRNQVLEIRLARTSDTDGGEST TPA_BK010830.1 DAC79493.1 tpg 19206 19457 - gas-vesicle-associated protein GvpG Loose gnl|BL_ORD_ID|2324|hsp_num:0 FONA-6 26.53 3004793 penam antibiotic inactivation FONA beta-lactamase MFIIDDLFVSPFFSLLDILQTMALDEMYDTKSIRDDIKENQLLYEVGERSDEEYQQRKQALESQLEMAEQVQEQMRDRMEVKK TPA_BK010830.1 DAC79495.1 tpg 20095 20670 - PadR family transcription activator GvpE Loose gnl|BL_ORD_ID|663|hsp_num:0 LRA-8 35.9 3002487 cephalosporin; penam antibiotic inactivation subclass B3 LRA beta-lactamase MDDLLEELTADIDANAAISFAVTDLESVIESDGASDHADQPPDEGATQRYTDTPLTDDAVATMDGWLDNDQLHTISDAIVTEHIDEILLLLITVRDGACGKELLQDLRRLFGADLSPGTVYPHLNDLAVEGVLEVQKLSKRKVYRLSDPEGAFTRIDHMVDQLLLFSLVLKAVMTDCKARQSQSQGRETND TPA_BK010830.1 DAC79496.1 tpg 20673 22283 - regulatory protein GvpD Loose gnl|BL_ORD_ID|4829|hsp_num:0 HelR 30.61 3007208 rifamycin antibiotic antibiotic target protection helicase-like RNA polymerase protection protein rifampin; rifaximin; rifabutin MSSPNLAHPPTDYTGIVLFPRELSQFFMGDAGETLLINGAPGTGKTLFTIRGLDVLDRDSDVLYVSTRVDQETVHEMYFADHSSLDTTAILDLFQDPFELPLDVDVPFEKLDLDSLLEWIQEINAATTQLTIAFDSWELIYEYLAVRHDDPPDIKTVTNQLAVLAREENIRLMLVTETAAPSSLEYIVDGVVTLQVKEDDRGRTRRDLRLDKLRGVRIGNRLQPFTLADGQFQVITPVELLTIQTGTGNGTWDPLANSKAKFSTGIRDLDRILSGGYNRGSVVHLDLGPDLSRDAWSVLTLPTIRNFLSQEMGVAVVPPREGSPGLLHNDLNTVLSSQVFDTYCHVFETYAGPSDSADRYDQPDSTESFSEMATTTPPDDAPTATHETDGADDGSRSTDGVTGSDQPHPIDEDFESPIEGGQLAYEPYMAYVEQVREESEDPLLHVISMDTAQEAFETRLGDFANYVALHNDLTLLITKQGTELRTRADRVADMHFRLERSGDAIILYGENPLTPLLGIGISQSESIPKITLTEMV TPA_BK010830.1 DAC79497.1 tpg 22484 22714 + gas-vesicle major structural protein GvpA Loose gnl|BL_ORD_ID|1011|hsp_num:0 AAC(3)-VIa 69.23 3002540 aminoglycoside antibiotic antibiotic inactivation AAC(3) sisomicin; 6'-N-ethylnetilmicin; gentamicin MAQPDSSGLAEVLDRVLDKGVVVDVWARVSLVGIEILTVEARVVAASVDTFLHYAEEIAKIEQAELTAGAEAAPEA TPA_BK010830.1 DAC79498.1 tpg 22804 23952 + gas-vesicle minor protein GvpC Loose gnl|BL_ORD_ID|491|hsp_num:0 emrY 29.17 3000254 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MSVTDKRDEMSTARDKFAESQQEFESYADEFAADITAKQDDVSDLVDAITDFQAEMTNTTDAFHTYGDEFAAEVDHLRADIDAQRDVIREMQDAFEAYADIFATDIADKQDIGNLLAAIEALRTEMNSTHGAFEAYADDFAADVAALRDISDLVAAIDDFQEEFIAVQDAFDNYAGDFDAEIDQLHAAIADQHDSFDATADAFAEYRDEFYRIEVEALLEAINDFQQDIGDFRAEFETTEDAFVAFARDFYGHEITAEEGAAEAEAEPVEADADVEAEAEVSPDEAGGESAGTEEEETEPAEVETAAPEVEGSPADTADEAEDTEAEEETEEEAPEDMVQCRVCGEYYQAITEPHLQTHDMTIQEYRDEYGEDVPLRPDDKT TPA_BK010830.1 DAC79499.1 tpg 23949 24992 + gas-vesicle operon protein GvpN Loose gnl|BL_ORD_ID|4984|hsp_num:0 Clostridium perfringes cplR 27.63 3007644 lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; pleuromutilin antibiotic antibiotic target protection Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins lincomycin; clindamycin; virginiamycin M1; retapamulin; iboxamycin MTNESRKRKVRGSQIRSSRGDKKQGRSQSRDDKEIERLERQNDARGQESSTHVDEGFVPEEQSFIETESVNRVESRMERWLDVGRPVHLIGPTGCGKTSLAMHVARERDRPVVWINGDAELTTSDLVGEYAEKERISEHDQFIHNVVKSKDIIRDRWVDNPLTLAVQEGATLVYNEFSRTKPVANNVLLSVFEEGVLELPGKRGKSRYVDVHPEFRTILTSNSVEYAGVHEPQDALLDRLIGIYMDFYDLDTEIEIVRAHVDKSADTNVEDIVRVLRELRERLDITVGTRAAIMANEGATTVDTVDQAVLTDICTDVLASKVAQRSDVRGLREEIESAIDDMEVALS TPA_BK010830.1 DAC79500.1 tpg 25017 25376 + gas-vesicle operon protein GvpO Loose gnl|BL_ORD_ID|1787|hsp_num:0 MexB 25.42 3000378 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole MADPANDRSEREEGGEDDETPPASDGNPSPSANSFTLSNAQTRAREAAQDLLEHQFEGMIKAESNDEGWRTVVEVVERNAVPDTQDIIGRYEITLDGTGDVTGYELLERYRRGDMKEEL TPA_BK010830.1 DAC79501.1 tpg 25405 26169 + ParA domain protein Loose gnl|BL_ORD_ID|2562|hsp_num:0 HERA-8 36.0 3004822 penam antibiotic inactivation HERA beta-lactamase MAHRLTVANEKGGVGKTTIAINVAGALADRGHDVLFVDLDAQGNGTIGLGLDAAYTGDGISLYDILTDLDAQQQIDAVIRSHEEFDVLPSHIDMFSAESELQTAMRGRERLWMALDELHADYDYIIIDAPPSLGLLTDNALLACRNVLIPALPEEASRHALDILFGHVDTLEDGYGVDIDPIGLVANRIEVDGEADRILEWFDEQYKSLPLWRIRNRVGIKRAWANGTSVFGHSETTDMDERFQAIAAHLERTE TPA_BK010830.1 DAC79502.1 tpg 26683 29202 - receiver/sensor box histidine kinase Loose gnl|BL_ORD_ID|2785|hsp_num:0 ParS 31.6 3005067 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux; reduced permeability to antibiotic resistance-nodulation-cell division (RND) antibiotic efflux pump; Outer Membrane Porin (Opr) erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; imipenem; chloramphenicol; norfloxacin; ofloxacin; gentamicin MARTRNPGRGGGGSIQVLHVDDEPDFADMAAEFLEREDDRLTVESATSASEGLDRLDEHDYDCIVSDYDMPGMDGVEFLETVRKAYPNLPFILFTGKGSEQVASEAIAAGVNDYLQKGSGSEVYELLGNRITNHVERVRAQRKQQRHLDAIETAQEGISILDEDEHFRYVNQSFADLYGYEPAEMIGEHWELIYPDEEVQAINEEVLSIVEETGYWRGETTGLRADDSTFIEAHTLSQTDEGGLICTARDITEAQEQAQELEEVTQQYRTVVEQSRAGIRIVQDGTVKFVNDRLAEMLGYPKHELLGAPAEEIITSETEDIVRRHHATRMQGEPAPDRYEVEVDTEAGDRLCVELSVARIQYAGKPASLSLIRDITERKEGEQALERYAALFDNAPDATALVEYRDETPIIRDANPAFEALFAGGDGDIVGQDIDGVVASSDQVAEARTISQQVQEGEPIQKELTRETADGLRTFDFRSVPVEDRETGEIESAFVIYPDITERKAHRRELERYETLVEATADPMYMLDEEGRFTYVDDAMVETTGYSEETLLGEHVSKVMEEDHVERGEQLIESLLSSGEKRGTFEMVIETAGGERFSTENHISLLDGDGEFHGTAGVLRDITDRLERERQLKRERDRLDEFASVVSHDLRNPLNVAEGRLELAMENCESEHHDSVAQSLDRMESLIDDVLSLARAGEAVGETEPVELADLVEACWQTVETASAGLVVETETTIQADPSRLQQLFENLLRNAVEHGGEDVTITIGDLPDGFYVEDDGQGIPEDERGNVLDAGYSTAADGTGLGLSIVREVAEAHGWEIEVTESSDGGARFEIIGVQMEG TPA_BK010830.1 DAC79503.1 tpg 29637 29789 + small CPxCG-related zinc finger protein Loose gnl|BL_ORD_ID|4692|hsp_num:0 Staphylococcus aureus mupB conferring resistance to mupirocin 60.0 3000510 mupirocin-like antibiotic antibiotic target alteration antibiotic-resistant isoleucyl-tRNA synthetase (ileS) mupirocin MNGDASILGRCPDCGERISEAWLLVEYEKDDGETGIWAECSTCEGVVSPK TPA_BK010830.1 DAC79504.1 tpg 30044 30346 + homolog to TATA-binding transcription initiationfactor Loose gnl|BL_ORD_ID|1813|hsp_num:0 OXA-47 29.27 3001781 cephalosporin; penam antibiotic inactivation OXA beta-lactamase; OXA-1-like beta-lactamase oxacillin MEDPKDTITIENVVASTAIEQELDLSRVAMDLEGADYDPEQFPGLVYRLDEPSVVALLFGSGKLVITGGKHPVDAEHAVDTIDSRLEDLGLLDGYGDRAK TPA_BK010830.1 DAC79505.1 tpg 30622 31896 - ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|2194|hsp_num:0 catII from Escherichia coli K-12 39.53 3004656 phenicol antibiotic antibiotic inactivation chloramphenicol acetyltransferase (CAT) chloramphenicol MRRLTTLFPSEFLEDHAEELGVVERDRKLQIPAFVWAFVFGFAAGESRTLAGFRRCYNSTADETISPGGFYQRLTPTLAEYLRDLVEHGLDEVAVPNAVDADIDRFRDVMIADGTVLRLHEFLSDQFEARHEEQAGAKLHLLHNATEQTIEQLDTANEKTHDSTLFKTGPWLENRLMLFDLAYFKYRRFALIDENDGYFVSRLKQNANPLITGELREWRGRAIPLEGKQLRAVLDDLDRKYIDVEVEVEFKRGPYNGTQSLDTKRFRVVGVRDEDADDYHLYMTNLARKEFFPADLAEIYRCRWEVELLFRELKTQYELDEFDTSDEHVVRILLYAALLSLLVSRDLLDLVTEQADDELVFPTERWAATFRSHAQLILHELGEFLGYSPPPLLDRLIEDAQKIHKQRPILQETLATTTQPRCEA TPA_BK010830.1 DAC79507.1 tpg 34534 35361 + ISH9-type transposase ISH9 Loose gnl|BL_ORD_ID|1560|hsp_num:0 Erm(39) 38.46 3000602 macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase erythromycin; roxithromycin; lincomycin; telithromycin; clarithromycin; clindamycin; tylosin; spiramycin; azithromycin; dirithromycin; pristinamycin IA; quinupristin; virginiamycin M1; madumycin II; griseoviridin; dalfopristin; pristinamycin IB; virginiamycin S2; pristinamycin IC; vernamycin C; patricin A; patricin B; ostreogrycin B3; oleandomycin MSKISRFTKKAVQLAKNAVGGRGEVAAPEGGGGFADYAIVSLHCLRVYLEKSYRETLDLLSEMPHILAEIGLNEADLPDHSTLVKAFDRLKTALWRVLLRLSAQLHDPSGHAAIDATFFDRETASKHYCRRTNYRVQTLKTTALVDTETQAILDVHCSTGKPHDTQLGWQVARRNAGDLASLAADKGYDWMELRKKLREDGVRPLIKHRIFRPIDHAHNARVDGPRYRQRAMCETVFSTIKRTLGDAVRARAWFREFREIVLKCVVHNIKRAVTP TPA_BK010830.1 DAC79508.1 tpg 36819 37811 + ISH11-type transposase Loose gnl|BL_ORD_ID|4561|hsp_num:0 RAHN-2 35.29 3006980 cephalosporin antibiotic inactivation RAHN beta-lactamase MSPATLQDDPSVDSFFNVVETETLALFEHLSFEFLEEFDVFAPAETGRTRDHEPPELMRGFLHCYYKDIYGIRPVERELRNTVVWLSCGFDRPPSRDAVDRFLTDLEHVVNKVFDHLVEQAALRGLLDLTYCIDSTDVRAMPADQDASKCYDPTDDEYYHGYGCTIVSTGQKIPIAAEFTESKQAPEETAMRVTRDALAVAKPIWMVGDSAYDTLDWHDHLLAAGVVPVAPYNARNTDDPKDIEYRVEDRIEQHSEDVQLKQSTLDETYNRRTGVERTNESVKDCGLGRTHARGRVHARAQVFLALCLRLVVAITNYERGDNPGSPIITV TPA_BK010830.1 DAC79509.1 tpg 38251 38520 - uncharacterized protein Loose gnl|BL_ORD_ID|2347|hsp_num:0 basS 41.46 3003583 peptide antibiotic antibiotic target alteration; antibiotic efflux pmr phosphoethanolamine transferase polymyxin B MSQNTVNTTVSIKPADALFLSWATGTNASGLFREAVAEQMMYRDIDRDELSTLTEEALTETSRDLDDLLEQTSSIEDLNTLLETDPASD TPA_BK010830.1 DAC79510.1 tpg 38679 38900 - uncharacterized protein Loose gnl|BL_ORD_ID|2305|hsp_num:0 tetA(46) 33.33 3004032 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MNYPSLRGYGAVLVVGVAVICMGVIALGFIMPTRLFESTVGLVAFFAAALLMVICAVVANFYDLREVLHEEFG TPA_BK010830.1 DAC79511.1 tpg 39204 39371 - uncharacterized protein Loose gnl|BL_ORD_ID|4666|hsp_num:0 vanS gene in vanB cluster 45.83 3002932 glycopeptide antibiotic antibiotic target alteration vanS; glycopeptide resistance gene cluster vancomycin MSDLIVKAAVKDELSEHNVSADFYAALNEEVAELLDDAADRAEANERKTVQPRDL TPA_BK010830.1 DAC79512.1 tpg 39504 39785 + PadR family transcription regulator Loose gnl|BL_ORD_ID|2039|hsp_num:0 mphG 28.57 3003742 macrolide antibiotic antibiotic inactivation macrolide phosphotransferase (MPH) erythromycin; clarithromycin; azithromycin MHDLTGFQRDILYVIADFEEPHGLALKDELEVYYEQEINHGRLYPNLDDLVDKGLVEKGELDERTNSYTLTQRGHREITARRDWEQQYVDLSE TPA_BK010830.1 DAC79514.1 tpg 40577 40747 - small CPxCG-related zinc finger protein Loose gnl|BL_ORD_ID|3290|hsp_num:0 AXC-3 40.0 3006899 carbapenem antibiotic inactivation AXC beta-lactamase MGENCDKCGTELGSSQERHQRYRIEHPSDSVETLEGRLCSDCFWELKEWLETEEVT TPA_BK010830.1 DAC79515.1 tpg 40819 41202 - uncharacterized protein Loose gnl|BL_ORD_ID|4680|hsp_num:0 vanS gene in vanF cluster 30.43 3002936 glycopeptide antibiotic antibiotic target alteration vanS; glycopeptide resistance gene cluster vancomycin MFTVDETYDGFEFTLRNQTTASLTITRTKAWEIERHTSDGWEQVATEVGVAEGKTRTLDCGEAHSWHHALFEHPTLPSRKTTYLFENLSEGLYKFSVTGNLETGVEITRETQFEVQRQLPPQTKTDE TPA_BK010830.1 DAC79517.1 tpg 42257 43705 + cytochrome bd ubiquinol oxidase subunit I Loose gnl|BL_ORD_ID|3409|hsp_num:0 CRP-1 25.97 3006868 carbapenem antibiotic inactivation CRP beta-lactamase MVPATLLSTVDLGWMALLSPEIASRMQFGWTISVHIIFASLSIGLAPFIIYFTWKDVRTNEQRYARLRSFWVKVFAVGFVMGTVTGIPMSFQFGTNFPQFATIAGELIGGPLAFEAKMAFFLEAVFLGVLLYGRERVADRTYVLSSVLVGVGAWLSGFWILVVNAWMQTPRGYEMVTRNGMEVAKLTDPVAAFLTPRMPWMYVHMMNASVISVALLVAGVSAYLVWKKPDADAWNSALKLAVVLLLVSAPFQAVHGDAYGRHVEDTQPQKFAAMEAHYETGSADLHLLAFPKSLDALTDPRTENLFTVSLPGIGSFLASGGDFDAEVIGLNEYEENPPVALVFWSFRFMVGLGFLFIGLALWGGYLTYRGRLTESTRYLKSMIAASPFGYAALLTGWYVTEIGRQPWVIQGELKTSEAVSSTLTGTEATLTLVGFVVLYIALILTALYVLKWLIRGELRSLGVQESSAGRWRGPLPWVTSDD TPA_BK010830.1 DAC79518.1 tpg 43698 44693 + cytochrome bd ubiquinol oxidase subunit II Loose gnl|BL_ORD_ID|1197|hsp_num:0 mef(B) 44.19 3003107 macrolide antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump erythromycin; azithromycin MTDPLIPVDTYLVDSLPEVWFGAVVFALGMYIVLDGFDFGIGMLYATRTDEHERETFLAAFGPVWDANEVWIVAFGTMLLAAFPRVYSRLLADNYLLALGFVVALVFRGLGPELREQREDERWKRYTDYAFVGGSVFAPLLLGMLAGRWLFAGATLPVVLTGVGLVAVSIVTGAAFLAAKTDSGLASELRSYGVGATVAYLGGVVVLLGTVVATDAGGAASAVLSLPVAAVVALSIVAGLGGSVLARRGRYRAWLASALALPTLLTLLVAVLLYPTVYPPTGLLVREAVVSPLALNLVTVLGFPVLLLVLWYFKFLYGVFSGPIEGEGYGG TPA_BK010830.1 DAC79519.1 tpg 44812 45384 - DsrE domain protein Loose gnl|BL_ORD_ID|4843|hsp_num:0 MCR-4.6 38.89 3007231 peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase colistin A; colistin B MSTDTPDASVDDAPSRAELAARVNELEDALAEATSEDDAKKMSIISTKGTLDMAYPPLILASTAAAFGYEVTVFHTFWGLEILHEERSKNLKLSSVGNPNMPVPNAVAALPGMDRVTTKMMEKKIDDNDTATIEELIETSLDMGVEFQACQMTIDLMDYDEDDFYDGVTTGVGAATALQDMAEADIQLLV TPA_BK010830.1 DAC79520.1 tpg 45387 45632 - UPF0033 family protein Loose gnl|BL_ORD_ID|741|hsp_num:0 mecC 41.38 3001209 penam antibiotic target replacement methicillin resistant PBP2 methicillin MSADYDITETLDVKGASCPMPVVKTKSAIDDLAEGEILEVLATDSGSMSDIDGWASGTAGVELVDQEEGDDVYKHYVRKTK TPA_BK010830.1 DAC79521.1 tpg 45882 47075 + rhodanese domain protein / beta-lactamase domainprotein Loose gnl|BL_ORD_ID|3333|hsp_num:0 CAR-1 35.11 3006903 carbapenem antibiotic inactivation CAR beta-lactamase MNADDFPTPDADVESVDPESLKDRIDAGEDVTLLDARMTSDYEEWHIDGENVTSINVPYFEFLEDDIDEDVLDQIPDDREVTVLCAKGGASEFVAGTLAERDYDVDHLEDGMNGWARIYDAVEVEGYDGAGTLLQYQRPSSGCLGYLLYDDGEAAIIDPLRAFTDRYLDDADNLGVDLQYALDTHVHADHISGVRNLAEEDIEGVIPEAAVDRGITYADDMTTAADGDTFDVGDATIEAVYTPGHTTGMTSYLVDDSLLATGDGLFIESVARPDLEEGDDGAPDAARMLYESLQERVLTLPDDTLVGGAHFSDAADPAADGTYTAPIGELVDEMDALTMDEQAFVDLVLSDMPPRPANYEDIIATNLGQNAVDDEEAFTLELGPNNCAASQDSLAGD TPA_BK010830.1 DAC79524.1 tpg 47575 48033 + DUF4341/DUF395 family protein Loose gnl|BL_ORD_ID|467|hsp_num:0 tetA(P) 21.62 3000180 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MSDRHPAFMPLILVGGLIFGFGLAYSQMARPEVVLNFLQFEDFGLVFVMFGGAAVTGVTFFVAPRLLGRAPLTGDSFQRRLKSFDRNVLIGGAIFGVGWGLSGICPGAAYASLGIGNITILWALAGMFLGAYTQGFWRSHSQSRDASSAGAD TPA_BK010830.1 DAC79525.1 tpg 48044 49219 + transport protein (probable substratephosphate/sulfate) Loose gnl|BL_ORD_ID|2428|hsp_num:0 rpoB2 37.78 3000501 rifamycin antibiotic antibiotic target alteration; antibiotic target replacement rifamycin-resistant beta-subunit of RNA polymerase (rpoB) rifampin; rifaximin; rifabutin; rifapentine MDPALIALFAGAALASLFMAWVIGAGSSGATPYAPAVGANAISTMRAALLVGIFGFVGAVTQGGNVSEAIGSGLVGGISLPIAGVILVLVLGAGLMAIGITTGYPIATAFTVTGAVIGVGLALGGSPVWPKYQQIAAVWVLTPFVGGGIAFTIASLLPRPGVPERYSIPVLAGLVGAVLVNIQFSFLGAGSAAGTVRGVGQRVLAVDGLTSAVGITGFAALVVATVVWWDVSRDERGGLRRVLLALGSLVAFSAGGSQVGLAVGPLLPLLDEVGMVSTFAVLVGGGLGMLVGSWTGAPRMIKSLAQDYSSLGPRRSISALVPSFLIAQLAVLLGVPVSFNEIVVSAIIGSGAAVGGREAVDARKIGVTIGAWIGSFALSFALAYAAGALLL TPA_BK010830.1 DAC79526.1 tpg 49236 50012 - HTH-10 family transcription regulator Loose gnl|BL_ORD_ID|2576|hsp_num:0 ADC-164 40.54 3006336 cephalosporin antibiotic inactivation ADC beta-lactamases pending classification for carbapenemase activity MTGTANYVEFEPTRMGLYEASIRVKHECPYRRISERYPDLTIREWPLSDCQVLEITTETTPTDELLDEINEIGTVLYESADDNGYHVVTQSCLCSLEDSVIDRFEEHNCLYQSPTIYRQGWEHYTVVAFDSEDVRELLDSLRSDREIELLSKTSISETQIPHSMLAPANQLFEDITDRQLAALQLALESGYYEQPRKTSLRDLAERTAVARSTYEEHLRKAENKLLTNAGQFLRLVTATSTTNPLGVESGRRTEQTAD TPA_BK010830.1 DAC79527.1 tpg 50060 51169 + rhodanese domain protein / beta-lactamase domainprotein Loose gnl|BL_ORD_ID|1587|hsp_num:0 IND-4 25.81 3002260 carbapenem antibiotic inactivation IND beta-lactamase MQELSPAELGEQVQDDDGPLVLDIRHEEDFQEWHIPGSRNVDVYDELTDDPEQAIEPLDDLPSDEQIVTVCAAGVVSQTATAVLRELGYDAVTLTDGMNGWSRVHRHAELPVDVDGTLVQVARPGKGCLSHVLVSDGEAAVFDPSHYLNEYDTVLDEYDAELVGVFDTHAHADHVSGAADLADRHDVPYYLHQKDALAVDATPLEDGQTVTVGRLDIEVIHTPGHSEGSVSFDVEGAALLTGDTLFHDSVGRVELGVEAGIEDADVEGNAATLYESLQRLLDRPDDALVLPAHDPGSPEPPVAATLAEVRERNDDLGRDREAFVEELASDIPDHPPNFERVKRTNVGQESVPEEELAELELGPNNCAAE TPA_BK010830.1 DAC79528.1 tpg 51140 52390 - spurious ORF Loose gnl|BL_ORD_ID|4732|hsp_num:0 vanR gene in vanN cluster 22.22 3002929 glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanR vancomycin MGLLHPNVHYCTRRKHQARSQVKRGCCIHELHRESNQDRADSVAGITPHPVDAHPRRPPSRVSCVARNRHQVRVQQRHPEPGDPSQDGPREVAIDEHHPEDARAREEHPGNDGRTAADAVREPPGRNLEEVHRTVDTDDDPNRRDTEALTRQVQRDGNPEQCIDEVLYVAGLRRREQRPVAVRRALQHLVERQIRVVVVVVTLGLGVLDGLLNQEDGDEERQYDDHGEEVERFGPQTPLACDDTRDPGADSDASVAERLVDADREPALVGTREVDLRVDRHTPRQRLVDPQQDVPDRDPAPARGEDEDDRQRERRRPSGDEDGFATVRLAPLAGVEIEDRLHDPERDDERADHKERLDAEDVLPEYGDDCPFGTDGQAGREDEQDVQRELPEVFADPLAEFSGRTHGLLGRTVVWA TPA_BK010830.1 DAC79529.1 tpg 51173 52438 + major facilitator superfamily transport protein Loose gnl|BL_ORD_ID|1484|hsp_num:0 tet(41) 24.77 3000569 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MSTTTELRQGIREHLGQFSLHVLLVFATGLTIGSERTVVPVLGEDVLGVESFLVIGSFVVSFGIVKSILNLYAGKWGEAYGRKPVLIAGWATALPLPIILIFAPSWGWITVGNVLLGINQALTWSMAINAKIDLAGPDQRGLAVGIDEAFGYTGVAVGAWITGVIAGQWSLRPEPFYFLAVVVVLAFLISIFLIKETVQYAQAEGNDDHHDANLPFNEVLKRATYGDRTLFAAAQAGHIENFVDTLFWIAVPLYLTSQGLGIAAVGVVVGVHSAMYFLQIATGGLADRIGRRPPVVAGMFLAGAGVLGMVLVDGYLPWAVLAGVSGLGMALLYPNLMTVPSDAAHPTWRSAGMGVYRMWRDSGYAVGAVLIGLSMEFVNAAAAFYLTAGLMFASGAVVYVWMEETHPDFGTHEPPAPAPSD TPA_BK010830.1 DAC79532.1 tpg 53918 54322 + TrmB family transcription regulator Loose gnl|BL_ORD_ID|810|hsp_num:0 APH(6)-Ib 32.26 3002658 aminoglycoside antibiotic antibiotic inactivation APH(6) streptomycin MPDSMSEQLRQDMECEGLLECFHGLKELDKECFQALVEAEEPMTVDELAEAVDRERSTAYRAVQRLLQTGFIEKEQVNYEQGGYYHVYSPSDPSQITDDMQRMLNDWYAKMGQLIQEFETKYEQPDSVPQSAES TPA_BK010830.1 DAC79533.1 tpg 54498 54857 + thioredoxin Loose gnl|BL_ORD_ID|2297|hsp_num:0 Pseudomonas aeruginosa CpxR 34.55 3004054 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump neomycin; erythromycin; amikacin; ciprofloxacin; kanamycin A; tetracycline; tobramycin; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; gentamicin MATDTAATTGTASPDEPLYVNGQTELDDVTSDNDVVLADFYADWCGPCQMLEPVVETLAEQTDAAVAKIDVDENQALASAYGVRGVPTLVLFADGEQVEEVVGLQDEDALKDLIESYTE TPA_BK010830.1 DAC79534.1 tpg 56131 57249 - XerC/D-like integrase Loose gnl|BL_ORD_ID|1374|hsp_num:0 ACT-4 40.62 3001829 carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation ACT beta-lactamase MSNNDATPGVRGLETLLDDRMVSLESPQTQQITRVAVNNLFQFLTENNDVDSVADVDEQDARDWVIHLVKEDDLAANSIRTYFALARATFGWWQRSGEIGQNPLATTTAEEVLPSKSNDVEQQFWTADARERLLNYVDERAHAALENDSSDAARAFRDRSLVYILADTGVRGAEICSVSRDNRRNGLRWTDVDLEAGVMTVLGKSGDQESVSLPGVTSEKLARYRRLVDAPAEWPVIPTGDATSKYRAVRKQLREREYGDEAIEGVLEDCEIDEVLREYEVAPPALTTEGARTLLKRLCGEADVDIDGDYLKPHGGRRGLGDELYGEVAAESAQEVLRHKSIETTHASYRERRAEDLSADIEKVRYSNTDEE TPA_BK010830.1 DAC79535.1 tpg 56824 57273 + spurious ORF Loose gnl|BL_ORD_ID|1011|hsp_num:0 AAC(3)-VIa 31.94 3002540 aminoglycoside antibiotic antibiotic inactivation AAC(3) sisomicin; 6'-N-ethylnetilmicin; gentamicin MGALVDVVEQSFASIGSPELLLDVVALRREYFFGGGRRERVLADLTAALPPAKRGAREREIRPDGVRGEIVFFHEVDNPISSVLFVDVRDGVDIVVLGEELEQIVDGDPRDLLGLWAFEGDHAVVEEGFEAANPRGSVVIRHLNHASTR TPA_BK010830.1 DAC79537.1 tpg 57356 57598 + spurious ORF Loose gnl|BL_ORD_ID|2378|hsp_num:0 ANT(3'')-IIa 37.5 3004089 aminoglycoside antibiotic antibiotic inactivation ANT(3'') spectinomycin; streptomycin MVVAGIEVLVAASTGDDFAVVHDGAFGDRASFDVLVGYRRSLWDFHCSCLREGGHPLSSGLFYCSKPNQLQRSEITAFGL TPA_BK010830.1 DAC79538.1 tpg 57972 58352 + uncharacterized protein Loose gnl|BL_ORD_ID|131|hsp_num:0 cpxA 63.64 3000830 aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump neomycin; amikacin; kanamycin A; tobramycin; novobiocin; gentamicin MVSGWQVIRVACILSVSVGVGLLAISISLGLTAGTAPPVLVGFGGSVCTAYLLLRKHPNIETGPLWRFSGLVFVLFILGNAVSTEGIYAPQSEQSPLAIGGVWALSLLICYTVIFKVEWTNRSPSQ TPA_BK010830.1 DAC79539.1 tpg 58617 59891 + ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|2034|hsp_num:0 vanJ 30.0 3002914 glycopeptide antibiotic antibiotic target alteration vanJ membrane protein teicoplanin MRRLTTLFPSEFLEEHAEELGVVERDRKLQIPVFVWAFVFGFAAGERRTLAGFRRSYNSTADEPISPGGFYQRLTPTLAEYFRDLVEHGLDEVAVPDTVDVDIDRFSDVMIADGTVLRLHEFLADQFEARHEEQAGAKLHLLHNATEQTIERIDVTDEKAHDSTLFKTGSWLENRLVLFDLAYFKYRRFARIDENGGSFVSRLKQNANPVITDELREWRGRAIPLEGKQLRDVLDDLDRTYIDVEVEVEFKRGPYNGTRSLDTKRFRVVGVRDEDADDYHLYVTNLSREEFFPADLAQIYRCRWEVELLFRELKTQYDLDEFDTSNEHVVKILLYAALLSLLVSRDLLDLVTEQADDELVFPPERWAATFRSHAQLILHELGEHLGYSPPPLLERLIEDAQKIHKQRPILQETLATATQPRCES TPA_BK010830.1 DAC79541.1 tpg 60258 61340 - isopentenyl-diphosphate delta-isomerase%2C typeII Loose gnl|BL_ORD_ID|3890|hsp_num:0 OXA-640 25.37 3005861 penam antibiotic inactivation OXA beta-lactamase; OXA-184-like beta-lactamase oxacillin MTAQDSTQTEDRKDDHLQIVQERDVETTGTGFDDVHLVHNALPELDYDAIDPSIDFLGHDLSAPIFIESMTGGHHNTTEINRALARAASETGIAMGLGSQRAGLELDDERVLESYTVVRDAAPDAFIYGNLGAAQLREYDIEMVEQAVEMIDADALAVHLNFLQEATQPEGDVDGRNCVAAIERVSEALSVPIIVKETGNGISGETARELTAAGVDALDVAGKGGTTWSGIEAYRAAAANAPRQKQIGTLFREWGIPTAASTIECVAEHDCVIASGGVRTGLDVAKAIALGARAGGLAKPFLKPATDGPDAVIERVGDLIAELRTAMFVTGSGSIDELQQVEYVLHGKTREYVEQRTSSE TPA_BK010830.1 DAC79542.1 tpg 61626 62279 + TrmB family transcription regulator Loose gnl|BL_ORD_ID|4986|hsp_num:0 PSZ-1 25.0 3007648 cephalosporin; cephamycin; penam antibiotic inactivation PSZ beta-lactamase cefoxitin; cefazolin; amoxicillin; benzylpenicillin; ampicillin; cefalotin MVSSFVTLHKMSYDTEHVRNAGDTPGTITGIPTFAELLENPSLADLYTSIRQAETATGPELVETTTVSKKTVYDYLHKLEQAGLISKVGDETGTAVYTAQEFELTLTVRETEVSITPKIIEVIAQKNEYPAIERVLEDYGIVTFALAYDLVNAHSEGEVTIRQIASLTDLSPGTTYDLVEALYSVLDLGDDDSTPTTYTPDEFDAEGGDLLEEYADK TPA_BK010830.1 DAC79543.1 tpg 62291 62848 + uncharacterized protein Loose gnl|BL_ORD_ID|1876|hsp_num:0 TEM-60 25.27 3000929 monobactam; cephalosporin; penam; penem antibiotic inactivation TEM beta-lactamase ceftazidime; ampicillin MYTANIADTVMFRNLGKHPSPHLQSLKSAVEEAGTEVWVPAAVYHELADTGSADSPTNPYLDTAIEEGWLRVATPLPGDRTAGFESSAGPVEKARFVADEFLNQQSKYPETNNWQDAAVVALAVRLFDANARIRVITHTADENLAKACARIPPEFGYYDIKSRYYNPPQTAKVEFPTVGQLTWSE TPA_BK010830.1 DAC79544.1 tpg 63243 64667 + ISH10-type transposase ISH10 Loose gnl|BL_ORD_ID|2673|hsp_num:0 MCR-7.1 30.3 3004517 peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase colistin A; colistin B MVIVDRDDLSKDELLSRFLQMEERIDELEEKLEQKDERIEELETRLRKYENPHTPPSKRRSGTDESPTSQDDEDDDVRTDGGTPGRKDGHDPEWRSTTDPDEEIEVTCDCCPECGDHFDESVGVSPRLVEEIPDPQPPEITRYNRHYYQCDSCGTETVAAHPDCPDEGQFGVNVIAQSALSRYDHRLPYRKIADRFEQLHELELSGASAWHATERAARAGRCEYEQIRREIQDADVVHIDETGIKRDGEQAWIWTFKTAQHTLYAVRESRGSDVPAEVLGEDFAGTVICDGWTAYPAFSSNLQRCWAHILREAEDAAEKQAEGEPIYHALRQVYVALQARLESDPSPRERADLQRVARRELESLIERSVPDGPVATLLGKIEGGLDHWLTFVGEPAVSPTNNAAENALREPVVLRKIIGTLRNDRGMFVHETVLSLLATWRQQGRNPYEELRRVVSSNEMLSRAHAVPAVETSG TPA_BK010830.1 DAC79545.1 tpg 64901 65320 - uncharacterized protein Loose gnl|BL_ORD_ID|2563|hsp_num:0 OXA-156 31.34 3001461 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-62-like beta-lactamase oxacillin MADDGDPFADLSQTLDDDADDQDETKSEQEPREPPASDTTTEHVDEPDEGDVEELDPMTDTAFSYEAANQRPFYAREETIENFDSWLNYELERELSTRGYQNIVVREMTDALLRTVVEEDLVDEVAERFEQERKNAISK TPA_BK010830.1 DAC79546.1 tpg 65313 66251 - ParA domain protein Loose gnl|BL_ORD_ID|2140|hsp_num:0 ANT(4')-Ib 35.14 3003905 aminoglycoside antibiotic antibiotic inactivation ANT(4') dibekacin; amikacin; tobramycin; isepamicin MAGTNSGNSIDSTNSPNSPYDSVDTAGNSRAVSVCMLKGGVGKSTIAVNLARQLATHDHDVLLIDLDPNGHASVGLGFDDHYHNTDEGIGEVFFDEADPTSVVYDTEYEFDILPSSEDLEQVEREIVVGDVFQPSALLKREVVEPLLGDEYDFIVTDSPAYRSRLTDNALVATSNLVLPLAPGNEAMSGLERTIERQIAPLRKHMDVDVLALVPNMLDGRIDQQTQDRQLLERLNSHNSLQDRIPNFARITDWEAVGSGDISPTPGIRDRTSITKAYGERKPLLDYDANCDQLKNFDELAHIVEAGEVVRHG TPA_BK010830.1 DAC79547.1 tpg 66513 67316 - DUF1814 family protein Loose gnl|BL_ORD_ID|3156|hsp_num:0 ADC-129 39.29 3006304 cephalosporin antibiotic inactivation ADC beta-lactamases pending classification for carbapenemase activity MISQNRLRVLARELGVRQGYAEKNYVNSWILWGIFTSDFGENLMFKGGTALSKLYFPQSWRFSEDLDFGVEGQYNGSEDDLRDVLDTVTERSGIEFTISEHHESRQQHYPTHYVDMSIQYRAVLDHPNTTSLDVMVDEYVAFDSVHHTHSYEDIPEFELQAYSVEEIFAEKLRAIFQRGAARDYYDLYQLLETESVEIEFDVVLPAFEAKCDHDDLDVDLTTGLPGDQREDIQRQWETSLPDLTGDPPLFDTVWKRLDEAVIDKGTE TPA_BK010830.1 DAC79548.1 tpg 67322 68152 - DUF4095 family protein Loose gnl|BL_ORD_ID|2198|hsp_num:0 catB11 29.51 3004660 phenicol antibiotic antibiotic inactivation chloramphenicol acetyltransferase (CAT) chloramphenicol MSSTQETQTIRQGLSTRESRLLSHLAAEGHQIISIDDVEATLEVAPNTAREIASRLTEKGWLDRLLPGRYLIIPLAAGEEAVYTTHEYLIASHVAEPMYIGYYSALSHHGLTEQVPRTVYVVTPTRAQSREIHGVPYRVATVTERKFFGYEPTSIEGTVVNVADLAKTLVDCADHPEYCGGIRELATAMVAADDQACSWATVGEYLQRLDNGAATKRIVYLADQLSIDLPTRETLVESFTSGYSLLDPTQSEQGSYDSEYRLRINVDPGTLGPTES TPA_BK010830.1 DAC79550.1 tpg 68245 68682 - TRAM domain protein Loose gnl|BL_ORD_ID|4979|hsp_num:0 FRI-11 30.77 3007632 carbapenem; penam antibiotic inactivation FRI beta-lactamase ertapenem; meropenem; imipenem MVEVPESLQSLFSATVEKRGETYTLEVPQTEVDHGAISPGETYRIGVLTQRQSSTKTADERTAQEQPAPSERNSGPPTPPVTEGEVRDVTIETVGDQGDGIAKVERGYVVIIPGAQPGDEPTIEIDQVQENVAFASVVDTGPQSL TPA_BK010830.1 DAC79551.1 tpg 68917 69945 + Orc1-type DNA replication protein Loose gnl|BL_ORD_ID|27|hsp_num:0 msrE 47.37 3003109 macrolide antibiotic; streptogramin antibiotic antibiotic target protection msr-type ABC-F protein erythromycin MIRDARVLRAGFVPREVEHRDAEVNHLSSVLEPITNGEPADTAIVTGPSGTGKTCISQFVTERLREEVLNVEATYVNCWRNYTRFRTLYQILDDFGETIDIHRQSTPHDELIDRLQQYDGPRTVIILDEVDQLEDPGIIYDLHSLPHFAVICIANKEEDLFSRVDDRLVSRLRSSEHVRMDKYHDEQLHDILAARVKGGLDQDVITTNQLDRIADAAAGDARLAIGILRTAASKADRESRERITDDILLNAAEDARAQIKQKNLDSLIPHQRLVYDVVREHGPLGPSEIYDHYKRKVDDPRTKRTIRTYLSKMTQYNVLEAEGTSRDREYSLVDSTAPSVTQ TPA_BK010830.1 DAC79552.1 tpg 70849 71052 + insertion element protein (ISH2) Loose gnl|BL_ORD_ID|2305|hsp_num:0 tetA(46) 28.21 3004032 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MARTKMGVSIRTELVDELDSLVDECSDLGASRSEIVEAILTAYFQNDEDQIKQTRELIIRNRKRSNS TPA_BK010830.1 DAC79553.1 tpg 72330 73019 - UPF0361 family protein Loose gnl|BL_ORD_ID|2224|hsp_num:0 LlmA 23S ribosomal RNA methyltransferase 21.11 3003982 lincosamide antibiotic antibiotic target alteration Llm 23S ribosomal RNA methyltransferase clindamycin MCGRNALFVTQEDLEKHFGAEVVTDGGYAPRYNIAPGEQLDVITNRAAAEIDQYHWGLLPSWADDPGEGIINARSETAAEKRSFRDAWDSRPCLVLSSGFYEWQKRDSGPKQPYRIYREDAPAFAMAGLWEVWEGEESAIPCVTILTTEPNDLMQPIHDRMPVVLPDGDEETWLTASPDEREELCQPYPEEDLTAYEVSTRVNNSGNDDATVIEPLDHEQSGLDEFSSR TPA_BK010830.1 DAC79554.1 tpg 73259 74656 - DUF262/DUF1524 domain protein Loose gnl|BL_ORD_ID|1608|hsp_num:0 emrA 31.34 3000027 fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump nalidixic acid MVNANIWSRDFNLRSRIDEDIFEHLDQIGFGEIDRGTVTQTLALNIDGTCSTDAQKNLDPDDVRENWEDTKEAMISAIGYLRKQHGVKRSEFIPYEGMIPVLAYYMYETDRRNVDPDHQEQIDRWFWRVALSGRYSSSAQTRMTEDSKLVDRIIAGEDVEINFTPQISTERLKTTNIKRSTSGLRNAFLCLLARNRPLHFEDGSEIDLTENEYADFRLNKHHIFPNAYLRGLDYSKKERKSIMDITFIPAELNRRLSDTSAKEYFGRLANDVNEFERIMDSHLIPHDEDSGIWDNDYDTFQEQRAELVYSEFMELIGEYSALESDLRNDPQSAVKETEVLVRDFIDRELALASDGGTFWGEVPNDVNSNVQRRISEEQDSNPEFTVDSDRDKLDFCNVMDYAKIINARWDVFGDYLPSKSAVQTRFEDFAEFRNALAHHREIDRFTEMDGQVAIEWINSCITEEY TPA_BK010830.1 DAC79555.1 tpg 74812 75015 - insertion element protein (ISH2) Loose gnl|BL_ORD_ID|2305|hsp_num:0 tetA(46) 28.21 3004032 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MARTKMGVSIRTELVDELDSLVDECSDLGASRSEIVEAILTAYFQNDEDQIKQTRELIIRNRKRSNS TPA_BK010830.1 DAC79558.1 tpg 76754 78514 - uncharacterized protein Loose gnl|BL_ORD_ID|444|hsp_num:0 mphF 25.88 3003071 macrolide antibiotic antibiotic inactivation macrolide phosphotransferase (MPH) erythromycin; roxithromycin; clarithromycin; tylosin; azithromycin MHSPRPMAAALALFLVSSSAVVVVAGGMATVTPSDSGSVVPNDGPDYGVNNSTFQRLWSEDADNGNLSADDFDDANVSSRAEFAHRLARSTDIPFDQPPQAAGDWNNGDFGDYSPGDRDSSIHPESASLEDGVYIKDAYVSIFATQPSTILHQGNETTQYVAPDGQVRALSDYRVAVPQGDQNGSQRERWSIDQTSIESVELSADGRTIDTGNGHQATLQYTGLSGSPQLTVEANITVTLRHVTLDCPDWNSSISGCDGDWTRDVETLEASKTVSTSQKVVVNRLSGISGNRVQFETHKNRVGAVIHPSTEWSTITVDGDVRARSNWWFYTAGRSGWQTMVTTTATNTSRAESSVRPVQVHAFPSQQAPYVPTEPTDDGKRPLAIEETWGTELTGPSLPVNIDLESADPYVNADSIAVSSTTLDESAFRKVTVQGIVRGQSRTVSLSEQQTVRETNLDLTVTEANATHAVVRAMVTENASDDAVTTGRVTIRNQTATLNSSGMAVVTISKPSLLVHGQYQSAAWWRTDQPYAASEDITKTPANFPDFQTLIQLAVVTILWFIPVAVLVFGFDYMSDGALLGISNRT TPA_BK010830.1 DAC79560.1 tpg 79070 79339 - uncharacterized protein Loose gnl|BL_ORD_ID|649|hsp_num:0 cmlv 51.52 3002700 phenicol antibiotic antibiotic inactivation chloramphenicol phosphotransferase chloramphenicol MSRNTVNTTVSIMPADALFLSWATGINASGLFREALAEQMAYRDIDRDELSNLVDDALTDSDRDLDDLLEQTSSIEDMNALLEADSSTD TPA_BK010830.1 DAC79561.1 tpg 79817 81091 + ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|3754|hsp_num:0 OXA-491 43.75 3005725 penam antibiotic inactivation OXA beta-lactamase oxacillin MRRLTTLFPSEFLEEHAEELGVVERNRTLQIPVLVWALVFGFAAGESRTLAGFRRSYNATADEPISPGGFYQRLTPSLATYLRDLVERGLDEVAVPNAVDADIDRFRDVMIADGTVLRLHEFLSEVYEGRHEEQAGARLHLLHNATEQMIERIDVTDETAHDSTLFKTGSWLHGRLILLDLAYFKYRRFALIDENDGFFVSRLKQNANPVITAELREWRGRAIPLEGKQIQDVVDDLSRQYIDVEVEAEFKRGQYEGTRSLDTKRFRVVGVRNEDADDYHLYITNLPRDEFLPSDLATLYRCRWEVETLFRELKTQYELDEFDTRNPAVVEILLYAALLSLLVSRELLDLVTEQADDEIVFPPERWAATFRSHAQLILHELGEYLGYSPPPLLERLIDDAQKIHQQRPILQETLATATQPRCEG TPA_BK010830.1 DAC79562.1 tpg 82028 83194 + ISH3-type transposase ISH3 Loose gnl|BL_ORD_ID|3042|hsp_num:0 OXA-653 39.53 3005342 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-24-like beta-lactamase oxacillin MSTTQQADGEIHEDQLLNFLVNALDEEVALTLAENAEIDAEDIYEVLVGACADGTSVSTLCEKSEDAPHENSVLYHLRTKFDLETLEQVGNALLQKDVLDVLPQQVEVVSDLHLRPYYGDEDGTDGLYHSQAKRGTTAFHAYATLYARVKNKRYTLAVRRLEDGDTASSVLAEFLGILDGLDLDVKAVFLDREFYDSKCLTLLQAHNHAYVMPIVRWGQTIKQELSEGWSRVIQHDMTAKLDGHSWTVEFLVYIDCTYQNGRCDEHGVARHGYAADAPFIESPRDARYHYAKRFGIEASYRLSEQSIATTSTQNPVVRLLYVVVSLLLQNVWRYLHWEYVATPRRGGRRLWKWSFKEFINMIQRAAWTALATRRAVPANRPPDDRFTR TPA_BK010830.1 DAC79563.1 tpg 83525 84766 - XerC/D-like integrase Loose gnl|BL_ORD_ID|1706|hsp_num:0 FomB 34.29 3000449 phosphonic acid antibiotic antibiotic inactivation Fom phosphotransferase family fosfomycin MNQNTSSTRDGSTPLDDSFERYLQDKGKGRGGDGGNYRRNAARELERLAEWAAGDRGDDDWTGIVPDDVDRDPTFEDLDERVFREYARHLAGDRGLKQNTVQTYYRYISAWCGWCVNEGYLEAHYAQRASAMAPLPEDDGRKPGDQQAWTSEQRHTLTRHVDERARDAVEAYATLPADTDPLDKQRARYAALKAARDRALVFVLAYTAVRVGELLRDPNDPRRRGVRWEDLSLDDGSMDVYRKKQQWDAASLPDPVISPLRSYRQLMDPPTERWPVFPTFDHRTLATIVQDGLADQGERPDTITEQRDEYARNLLLALDEDVRPPSITTDGARSILQRLSDAAEIDIDHPKHDYLAPHGGRRGMGEVLVRAFGYTVAARYLDNSEEMVRERYSHIEAGELGDVATEALEEIDQ TPA_BK010830.1 DAC79564.1 tpg 84776 85381 - uncharacterized protein Loose gnl|BL_ORD_ID|3160|hsp_num:0 ADC-133 21.98 3006308 cephalosporin antibiotic inactivation ADC beta-lactamases pending classification for carbapenemase activity MASDDTRYPILVDTDALIAVANSPLWTEITDQIGLTTTNVCKQELKRHVENTRETAPEGSRPYQLHYGSRTALDALEDNETPLTQVTSVPRPHGADAGEESLRQEVLQNPGAVDYVILMDAAGRRSIRRAVDDQDEDIRVVTPPFLFYILYDNELISRCEFCEACGEMLEREGWTGYNAVKAAWEAIPIDCSDILDDHLLP TPA_BK010830.1 DAC79566.1 tpg 85817 86398 - HTH domain protein Loose gnl|BL_ORD_ID|4864|hsp_num:0 MCR-3.15 27.54 3007252 peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase colistin A; colistin B MASTYIKTKRERCCMTEDESNSVGLMERQTTGEDRVRMTARQLSEPRTANWIASEAGWSHEPTKRVLERLVDDGILHRDDSGTHTTYYPDHRRQAMQEAMRLRDSGHTVEELTDRLADMKTQIRDWEDEFDVESPNQLRGTLAEGDLDADEEDRRPEIAREWEHLQRRIQIVGFAIREWDFLAPTTEPAEASS TPA_BK010830.1 DAC79568.1 tpg 86874 88022 + spurious ORF Loose gnl|BL_ORD_ID|1823|hsp_num:0 blt 34.15 3003006 fluoroquinolone antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump acriflavine MRELVGRVEAVAFLGERQERVRGHRRLIADLAVQFQLHEYVHKSPAVVEDASEREVEVPEPVVGRLRLCEERLQFLEAVLDTPTPFVSGHQSPNLVFHLLLVGGIDIHPREIRLKGHGRRFDPRWLVDLLLFGDLVEKVAQRRVAVAVLRERRRVADVLEVLDEFLSDRHIRPVVVFVLTFPLALREVNRLPRRTGVQALLLDDIEVFVFTGKLSDLVFVVAAGPDDTGVEVVDVVRLADVFDAVRGELAVHHHQIESRDDVGRAFEEIVYDIRSLPTTNNRDGIKDQRDVVADEFDDCPLEERPVIALVAKNPRLLILSAAIAFNVAAPRVALREVDGRHLLAPHLVLRFRSRNKRPASLPEHRPDVLNAERLRLQPVGVA TPA_BK010830.1 DAC79570.1 tpg 89038 89376 - uncharacterized protein Loose gnl|BL_ORD_ID|4827|hsp_num:0 MCR-8.3 29.69 3007227 peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase colistin A; colistin B MPLHDNFDYWSPIAAFVALSLFVILALARPALPVALALALGVTVFVAGISPAVRERLPSYNRLIGAYCGVFGLARFASEGWTSVSAALVLVGVVSVLELAYERMTGRSADIV TPA_BK010830.1 DAC79571.1 tpg 89703 90164 - uncharacterized protein Loose gnl|BL_ORD_ID|4670|hsp_num:0 TolC 35.29 3000237 macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; cloxacillin; gentamicin C; tigecycline; ciprofloxacin; spectinomycin; streptomycin; tetracycline; tobramycin; oxacillin; ceftazidime; ertapenem; piperacillin; novobiocin; azithromycin; rifampin; imipenem; chloramphenicol; polymyxin B; polymyxin B1; polymyxin B2; polymyxin B3; polymyxin B4; ampicillin; nalidixic acid; norfloxacin; cefalotin; triclosan; ticarcillin; gentamicin MPNGDRDDVADRLSRRFDNDEEADEVSGEEEQAANAQQPPHEENASDAGNEENEGGKMNAEAEVSSRNAMHVRNVKSEWTSKSFYLPEFLKDDLKTTYKETDLEFEMERGEELPKTRHYYPLVVALGIERIARMDPQEINERIEGLEERGEPE TPA_BK010830.1 DAC79573.1 tpg 91037 91369 - spurious ORF Loose gnl|BL_ORD_ID|3526|hsp_num:0 FIA-1 33.33 3006887 carbapenem antibiotic inactivation FIA beta-lactamase MNSTRRWTSSATNCTKISRRTSAATPTTTTSVATSTAHPQAAKRSPTAASSSTAPFPACCTKKASRKPPFRTSILANCSFQQLSYHPIRMVLLRGSTTVHSDSGVHRGES TPA_BK010830.1 DAC79574.1 tpg 91218 91409 - uncharacterized protein Loose gnl|BL_ORD_ID|1787|hsp_num:0 MexB 24.0 3000378 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole MARNQGPVTDEEFDELHEEMDEQRDQLHEDLAENLGGDSDDYDVRRDVDGSSSSGEAVTHGGE TPA_BK010830.1 DAC79575.1 tpg 91385 91681 - uncharacterized protein Loose gnl|BL_ORD_ID|2711|hsp_num:0 Acinetobacter baumannii AbaF 42.86 3004573 phosphonic acid antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump fosfomycin MGYSHSSGHLTLFVVQFEDGEWAIVVRSNHDPEREHGYDVAEKGVYLDVYRDEEKYRSEELFPPMQPSEALTYAKDQIPMQPERYGTRFEEWHEIRAQ TPA_BK010830.1 DAC79577.1 tpg 92420 92614 + uncharacterized protein Loose gnl|BL_ORD_ID|65|hsp_num:0 fusH 72.73 3003026 fusidane antibiotic antibiotic inactivation fusidic acid inactivation enzyme fusidic acid MSPLLLSLLFFSVVVEMEKRNPITDSTVLSDPGGQKWVCELFYDTLRGCNTAVVTSVARPQTNL TPA_BK010830.1 DAC79578.1 tpg 92639 93613 + DUF2800 family protein Loose gnl|BL_ORD_ID|3412|hsp_num:0 CSP-1 36.36 3006871 cephalosporin antibiotic inactivation CSP beta-lactamase MPFSVTWNTLLERLDALHEEATLITPLSNNRIRITDVQDQRVIIQFRDRDIDQTRPLQRDQFETLYRRITEESGEFNLDRLPPDADPYPAVLTIHPQFELDADAGVITQTEGETSTQLRDSDPATDVDDRTEPDLDVYADALLVVDALERHEVADLSELETDALGTLYTLLSDLQRDANDLRKDVADVLLSRLHHDRPVSAPFGSVQRTTRQTRSLKDDETVLAAFEDAGIDRDRVLGVDRNKVDDALEVTDLSESDVYDIEESEYVRKAEVDEERKETRLQGLKDQLAATEGDETDALQEEISALEDRIDSLTSFQTGTDLQE TPA_BK010830.1 DAC79579.1 tpg 93610 94074 + uncharacterized protein Loose gnl|BL_ORD_ID|1673|hsp_num:0 tet(36) 21.01 3000197 tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein tetracycline; doxycycline; minocycline; chlortetracycline; demeclocycline; oxytetracycline MTTYQFRVKFEYAPTELWRDIIVGADRTLDEFQTVLNRAVGLDQDHLWFVGTDQDYWDSDVQYKCPSEFEQSSDGLVRGGEEYDAGETTVGQMARRLDLDEHDRLCYLFDYGDEWRFYAILKEITEDEPRDTEPAVVNRKGDPVDQYAPPDERL TPA_BK010830.1 DAC79581.1 tpg 95437 96846 - DNA repair helicase Rad25 Loose gnl|BL_ORD_ID|3748|hsp_num:0 OXA-159 31.11 3001464 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-62-like beta-lactamase oxacillin MRLAFDDGTLLLEDAPNSVPYADWDDRVDEYRARALHYQDLCQWAQGPDGQATLNQASHTDESLHDDARAYRDLDLTPAVAIEPRDYQQAALAAWTDHDRRGSVVLPTGSGKTFLAVQAIADASVSTLVVVPTIDLLNQWHATLTNAFGDQLPHEIGVLGGGSHNVTDITVTTYDSAYRYINEYGDQFGLLVVDEVHHLPAPTYQQIPEMTIAPYRLGLTATYERTDGEHNVLEDLIGPVVYEENVDELAGEYLSEYETIHLKVDLTPEERNQYDDEYQIYRDYLDNHDVDIWKQDGYQEFLKRTSYDPDGRRALIAKQRAEEIARTAEKKLDTLDNLLKRHYNDRTIIFTANNDFAYDISQEFIVPCITHQTQTDERTEILERFRTGEYSMLVTSQVLDEGIDVPAANVGIILSGSASKRQYAQRLGRILRPTEDREPARLYELITDDTMEQYVSKRRRQGVTTNADS TPA_BK010830.1 DAC79582.1 tpg 97175 97651 + uncharacterized protein Loose gnl|BL_ORD_ID|40|hsp_num:0 SME-2 40.54 3002380 carbapenem antibiotic inactivation SME beta-lactamase MISTCRSQRGQAIKYAGSEQRGDMLPDDLSVDQDKLLTWQTECWQCGEQTPIVWPRDDHLNTPIGGVLAKYDTPVERVYSNTLEKEVWGNVCQHCEAYQGNHYMEQEAVAIDPPFVECPNCGEEHEWRPDEGFGAAFGQGWVSCPEYGDVPVGDPRKK TPA_BK010830.1 DAC79583.1 tpg 97984 101370 + plasmid replication protein RepI Loose gnl|BL_ORD_ID|298|hsp_num:0 vanR gene in vanF cluster 22.22 3002925 glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanR vancomycin MSGHHTIWLVGCSHCSELWFTAAGRKTTDCPRCRTTYRTRTLRKFAEDTDRDALVEKRTQILASRSDPRARDQYRATVDDALTDYDSLEDAAQSSLIDEAAVRRHIGADDAADLRSANDESTTSSSSSSGMEEPESEHTNSFDPLGIPLPVAADSGISRIPPEQDGQTDLSTTVVYRGLQPQMRRWIPSLLEDLLPTLTAAVAQWTVDQDTLTLEDANTEGIATALLDKLDIDPGTVEIDGDRQAPVEVRAWVRDLVAFTVRAVEEDVTINDAPESLTRIGTGRGLLNAGRAALRAGPVALLDVLEVTPQVAATLNEGEWVGTRKETRARSLGALDSLSDALDIQLVFSTPRMESLLVEDHPDWTSRHLNLTEDADTSYPSKTDTAAGEDAALAREAWDILREREWSGTGYTRILGNIPASGATRGDLAADDDVSLSEGSIYAYVDDLAATGFVTIDDSTRPSRVVLTELGASIADYVDAKGSVQNPVQASLTQSPNRGTSECTPQHQQDPPGDSHQLGDDRVSAAESFLARTGDVSEDGYTRFLGRYSGGTAPREIEPATLHHQLQAGRCTEGVSVVEDANLQKFDDGRVSYLSGGPSFDDDVAVVLEWGNPLGTLARLVGTLLGSRAWSKILRRSRLGSSLENLWAGADQFDSALADVAKFGAQMGWMSSREESDYLSYRERLEAVRCSLLEDVGRFDDLDYEQRSALLSKLIGLATTATTLYHAAGYDLTVHLRVPDSKQLRRDDDRYGRFLAFFRSVVAKQGVYRGPDGVHSIYRMQRERRSEKLKRRLGYEIDPGDPRAELTCSWVVAVDGTGGEVASDIEGALCVEDHRVRERIQEGTEEAAVMDVPVVVANGAETTRRIVEAFAMKKGFSAGARQDLDRLVNVIHAALGTQERAPSPFDVAAVMQALESKDEPSDKLDVGALARGIATLPANRLLPSLFDEGERPKLAIQKMVRALLGSDGAVSRGDLVEVSSQNSVDRYLQRLRALDIVERVGPGEYRAYLEPWWVSGNGQSEPYSEAYDGEIAATGLGDGRWDAVLLGAAHELGADTASAASVEAFSQPVVFEEVLEAHPVLEQYEHILRVYVDGVEEDGPPSTVARIGSPPPGTAPDQQTLTAAVSSD TPA_BK010830.1 DAC79585.1 tpg 103281 103472 + uncharacterized protein Loose gnl|BL_ORD_ID|3539|hsp_num:0 GES-31 40.91 3006160 carbapenem; cephalosporin; penam antibiotic inactivation GES beta-lactamase MVHKIISRNPGNFGRVNVSTSDLEKLEIETSEDIDIDVADTEDVAHTFIDSKNVDRFLITTPQ TPA_BK010830.1 DAC79588.1 tpg 109051 111990 + ATP-dependent helicase Loose gnl|BL_ORD_ID|1350|hsp_num:0 AcrF 26.15 3000502 fluoroquinolone antibiotic; cephalosporin; cephamycin; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump ciprofloxacin MTDFEVGDHVKFAGGRGEITKIEDRPNGGQLLHIYTTEGKLRKLPSGLPHIERIDSIIDRLAARQIDSPIHHDLRERATRLDLAYRYDRFLSLTNNRIEIEPYQVQAAYEILNSYDHRYLIGDEVGLGKTIEAGIVTEELIARGRAQRVLIVAPAPLTVQWQQEMREKFDRNFVIYDRETVRTHRNSHPNQNVWLQEDLIITSIDFAKQDDVLEALRNLDVPWDLAVFDEAHHLTARRGSDESIERTQRYTVGEAVAENSDALLLLTGTPHKGKSDQFYFMVNLLDPYRFGHESQIHPDELDDLMIRRLKEDMYETDGTRMFPEKNIEALGVEMSPAERKLYDDVTEYIREYYNLAQQEENKAAGFTMVIYQKRLVSSIYAIQKSLENRMRAIQNDAVAEDLPDDVQELIPRYSTEPETLTDAERERVEAALETVTVTLNQSQIQEELDRVKQLWRQAKSIETDSKAQMLKQFVDRILTEDPDEKILIFTEYTDTLEYLRDRVFAEYDIAQVYGDLDQDRRRQEMADFENEKNIMIATDAAQEGLNLQFAHIMANFDLPWSPTRIDQRMGRLHRYGQERTVEIRNLFFKDTRESEILNLLVEKTDQIESDLGMRSDVLGRVLEDVDLDDTIMAAIAEDRPTDEVVADIDETIEERKNALETVENEFLIRDRFDLSDEDDEILDVIERSQHGDVSEDDIEVLVREFFDEFGGDIRGVRPGPARAGGDVFQLDVPDVLSGDQVAGRYEQATFTRQVAMEEDDVDFIALDHPLVQSLIEFCLDSNRIDGQVAVKVASDGEPAPGILFTYRLGYVSGAGEAVTEKLVPLYVTSESEVSTRKPEFVDTLPPGEVGSTPTLDQLTSMAEDLHSIAEMEAWEQVESFADEAREEREREVEIKRQHAEQHFEEEISEWEERLESYEQQDEQGKDMSAPIGNAKRELESLRRERDEELARLEEEKHVTPEEPELMTTSLVLDNQPGER TPA_BK010830.1 DAC79589.1 tpg 111987 112532 + TATA-binding transcription initiation factor Loose gnl|BL_ORD_ID|2390|hsp_num:0 TMB-1 39.13 3004105 carbapenem; cephalosporin; cephamycin antibiotic inactivation TMB beta-lactamase ceftazidime MTVEIANIVGSGDLGVELDVEPLEADLSTPYSEYDPSNYHGLYVRLEENGPLITVYRSGKYIITGCASMESLHETNEEFLGMLADLGVTEEDTQTGFTVENVVCTAMLDELVSLNALAIGLGLEVTEYEPEQFPGLVYRPEEIGAVLLVFANGKMVITGAKDTETAESAYEYFQSKVQELV TPA_BK010830.1 DAC79590.1 tpg 112973 114127 + YidE family protein Loose gnl|BL_ORD_ID|274|hsp_num:0 chrB 31.03 3001302 macrolide antibiotic; lincosamide antibiotic antibiotic target alteration non-erm 23S ribosomal RNA methyltransferase (G748) tylosin; chalcomycin; mycinamicin MAFIDTLVGSGVFVMFLAVVVGMAFGRINFGRGIKFGVAGPLFAGLVLGHFGFTVPDAYSGLTLALFVAAVGLIAAHEIEGTVKTYGLNFIAISVLMPTIAAILTYVWVVVVFPNASTGLIMGSFSGALTSSPGLGSAIEALPEAAAQQYQIGHSVGYVIGVLIIVMFQQLYPKLSGMNLDAEKQQFSEKVSDIAENANIEVVTFSVLGFALVLATGTVLGSIPIPLGPIGVITLGTTGGVLITALVLGYLGKIGPVTMRMETTILSEIRAFTLAMFLAVVGIDAGSGLVETIAEYGVEIVVTAGLNSIVAIIGGLVLTRVIWKMDWIHAAGGITGGHTDTKGLAAAIDATGADEVAAGYGNTYPFALLAMVIYAKILVAVIPL TPA_BK010830.1 DAC79592.1 tpg 115111 115512 - uncharacterized protein Loose gnl|BL_ORD_ID|2799|hsp_num:0 msrF 37.5 3005087 macrolide antibiotic; streptogramin antibiotic antibiotic target protection msr-type ABC-F protein erythromycin MSAILEREVDEQVHELLQDKKGEFLTAEIVAAATDYSESYVRERLHGLADNRGTDVTRDRRSKDIYGVIVGSGFVVITSDREQLLGIVRRNRPSEMGKAKSMTTDELQTFITEEIAVKEVATSTDKLYFGIPE TPA_BK010830.1 DAC79593.1 tpg 115884 116498 + uncharacterized protein Loose gnl|BL_ORD_ID|1787|hsp_num:0 MexB 26.87 3000378 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole MSDSSESGNSRYSGILTPKDKENIQTINWGNQDSADRDARHRVRQRVLEGLNDLKLLNNYLHREDRTQIFDEFLRGDGAYHAYAFVYLGILDTFPERDADEQLDVLEDVLQRSIEIGDAQRGLVSDVSIDVDISRRNTDPQSVLDTIFEGHGTLSHLSYLMQQGEDIHLLERVLDSGETVVLDAGDDTMSITPEEAQQILDEME TPA_BK010830.1 DAC79594.1 tpg 117104 120490 + plasmid replication protein RepJ Loose gnl|BL_ORD_ID|298|hsp_num:0 vanR gene in vanF cluster 25.96 3002925 glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanR vancomycin MSGDHPRWLVGCSTCEELWLTAATRDTTTCPRCRSTYRTQTLRKFAEDTDRDVLIEKRTQILASRSGPRAREQYRTTVDDALATHDSLDDAARSSLIDEEVVLRHLGADDTADLLYNTRESTTAPDSAAEDPDSGHANPTLDPLGVALPVAGDPGISRIPPERDGQTDLSTTVVYRGLQPQLRRWIPSLLEDLLPTLTAAVAQWTIDQDTVALDERDTEAIATALLDTLEIDPGTVEIDGDRQAPVEVRAWVRDLVAFTVRAVDDDGVAVDDAPNSLTRIGTGRGLVNAGRAALRAGPAALLESLEVAPQVAATLNEGEWVGTRQETRTRSLDALDTLSEALDIQLVFSTPRMETLLLEDHTDWTRRHLSLTDITETSHPAAPDTAGDADAALARQAWDILREREWSGTGYTRILGNLSASGATRGDLAADDDVGLSEGSIYAYVEDLAEAGFVTLDDTTRPSIVQLTALGASIADYVDTEGAVQNPAQASLTQSPNRDTRECTPQPDQELPRDAPRPGDDRVSGTESFLAATGDAKEDGYTRFLGRYNGGTAPREIEPATLHHQLGAGRCTEGISVVEDANLQDFEDSRVSYLSGGPSFDDDVSVVLEWGNPLGTLARLVGTLLGGRAWSKILRRSRLGSNLENLWAGADQFDAALADVATFGAQLGWMSSREEDDYLSYRERLEDVRCSLLEEVGRFDELDHEQRSALLSKLIGLATTATTLYHAAGYELTVHLRVPDAAQLRRDDGRYGRFLGFFRSVVAKQGVYRGPDGVHSIYRMQREQRAEKLKRRLGYEIDPGEPEAELTCSWVVAVDEAGDEVVDEIEAALRAEDHRVRDRIQEGSEDAAVMDVPVALANGAATTRRIVAAFAMKKGFGAGARQDLDRLVTVVHAALGTQERGPSPFDVAAVMQALESKDDPADELDVSALARGIATLPANRLLPSLFDDGERPKLALQKMLRALLGSHGAVSREDLVAVSSKNSVDRYLQRLRALDIVERVGPGEYRAYLEPWWVPENGQSEPYREEYDGEIAATGLGTGRWDEVLLGAARELGEDTASEASIAAFSAPVVFEEVVEAHPILQQYEHLLRVYVDGVTEDEPSSTVARIGSPPPGAGPAQQTLTAGVSGD TPA_BK010830.1 DAC79596.1 tpg 122757 123641 - ISH4-type transposase ISH4 Loose gnl|BL_ORD_ID|4938|hsp_num:0 WUS-1 24.49 3007435 carbapenem; penam antibiotic inactivation WUS beta-lactamase carbenicillin; imipenem; ampicillin MMPIKTFVSERRAANLLAQIRWRNGVYCPSCRAESVIRYGSYRVFQRYLCKDCDRTFNDQTGTVFEHSAVALRKWFLAVYTYIRLNTSIRQLDAEIDVSYKTVYRRVQRFLRALDAPRPHLEGPVEIDEFYVKAGLKGRERDQPSRSRGLSTRGRGTYAEDKLPVFVLADRGTGERHVIPAKAATESRIRLLLADRQQESLTVYTDGFRAYDPLDEDDAFTREYVVHGDGEYVNGDVHVNTCESHASLARRWLSPHRGVSKDRLTPYLRAFQLRREVFRKPGKEALKTILETAL TPA_BK010830.1 DAC79597.1 tpg 124238 124582 + uncharacterized protein Loose gnl|BL_ORD_ID|2003|hsp_num:0 OpmH 37.5 3003682 disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump triclosan MAPAAAFDAISNSRRRRVVLSLSRSSGDVPVGDLAVEIAAIENELDPSKVGNNERASTYISLIQRHLDTLDGVSAVDYDDRSKTVTATDATEPLAEYIRRLQTACYKPDSEDAT TPA_BK010830.1 DAC79601.1 tpg 126536 126928 + HTH domain protein Loose gnl|BL_ORD_ID|35|hsp_num:0 golS 28.79 3000504 monobactam; carbapenem; cephalosporin; cephamycin; penam; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump chloramphenicol MPVPVDELTDDESFPVTPDTNEYEALDFLVRHHEYGFSPREIADRTDINESSVAKTMRRLEENDVVERSDEIYYVDPVRIDTIRARLTSVDAVVRLFEATPDDDAYAEAGWEEQVPTIDSTGGSDTSSFE TPA_BK010830.1 DAC79602.1 tpg 127082 127228 - small CPxCG-related zinc finger protein Strict gnl|BL_ORD_ID|4692|hsp_num:0 Staphylococcus aureus mupB conferring resistance to mupirocin 100.0 3000510 mupirocin-like antibiotic antibiotic target alteration antibiotic-resistant isoleucyl-tRNA synthetase (ileS) mupirocin MPKCQNCGSHVTDVYVRVFTPDDVTSPRACPSCETITRDRNGIREKRP TPA_BK010830.1 DAC79603.1 tpg 127391 127798 + uncharacterized protein Loose gnl|BL_ORD_ID|1708|hsp_num:0 rmtF 25.0 3002666 aminoglycoside antibiotic antibiotic target alteration 16S rRNA methyltransferase (G1405) astromicin; kanamycin A; gentamicin A; gentamicin MSGVVGFFDQANTPRLALVCVRRYSVIGFSKVVGRVANWGLNLLLGYRVIFSVCNTTVQIWLRVPSAVLTFRLIPKLSVIISRSNTDTSPRVVATTATSSLGSRAGIQRCNEHSWPGYRCFVMDRLASGVGSGFQ TPA_BK010830.1 DAC79604.1 tpg 127958 128110 + small CPxCG-related zinc finger protein Loose gnl|BL_ORD_ID|4693|hsp_num:0 Staphylococcus aureus mupA conferring resistance to mupirocin 29.73 3000521 mupirocin-like antibiotic antibiotic target alteration antibiotic-resistant isoleucyl-tRNA synthetase (ileS) mupirocin MSSQNSRLGDCPRCGATIHDWHVLVEYETNGRHRYWADCPDCGAVVDPDA TPA_BK010830.1 DAC79605.1 tpg 128116 128271 + small CPxCG-related zinc finger protein Loose gnl|BL_ORD_ID|2209|hsp_num:0 emtA 39.29 3004669 macrolide antibiotic; lincosamide antibiotic; orthosomycin antibiotic antibiotic target alteration non-erm 23S ribosomal RNA methyltransferase (G748) evernimicin MLRRLTRVLWSSEPESEASLVECKRCGTTLESKAVERCPECGSRDIATYFF TPA_BK010830.1 DAC79606.1 tpg 128181 128840 + spurious ORF Loose gnl|BL_ORD_ID|131|hsp_num:0 cpxA 26.77 3000830 aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump neomycin; amikacin; kanamycin A; tobramycin; novobiocin; gentamicin MQALWDDAGIEGRRAVSRVRQPRHRDVFLLTSPGPSQLLDVSAQLFTGGWRCCGGLLEEAEVGEPLMDDLECVVGVVWVAPTRDDEFAAAEQQHHNIGVVEAIDEAGELFGFVFDVFEAESDGDRVQVQILVQTAAADDILDVNRRTGRDVDTEVAEVFDDDTDGVVDVVDRLGAGADSFARVEDERRRFRIVEPVDDTRKIPGIVLSAGEVSCELLEG TPA_BK010830.1 DAC79609.1 tpg 130026 130631 + integrase family protein Loose gnl|BL_ORD_ID|235|hsp_num:0 dfrA24 25.83 3002856 diaminopyrimidine antibiotic antibiotic target replacement trimethoprim resistant dihydrofolate reductase dfr trimethoprim MRLEATAKEDEYKVWMTDAELTELRRAAASHRDDLVIQLGGYVGLRAFEIPQICPKHVKRTEDGDHYRLRVPKGKDTTGNGGKPRDAYLPADVEGDIHRYTNAEGIDRHESLVDLSERGVRDVVKRTAERAAEETSDEDFRYVSSHDLRRRFAQRLLVDEQVNPRVVMQVGGWDSFQAIEPYLNAPTPEVVNEAFEEAGLA TPA_BK010830.1 DAC79610.1 tpg 131122 131565 - FMN-binding domain protein Loose gnl|BL_ORD_ID|4783|hsp_num:0 nimK 31.73 3007113 nitroimidazole antibiotic antibiotic inactivation nitroimidazole reductase metronidazole MTTELSREESDTLLFESGTGVLALTDGTEAYSVPESFGYDGEILYFQFVHTPESKKMAFLETTETATFTVYDEQPAQSVIVRGTLEPVLEDEEAKAATAITENASIPTVNVYPDTKPNEFTTDYYRLTPTAITGRQFNVFTPTPGDQ TPA_BK010830.1 DAC79611.1 tpg 132354 133628 - ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|3754|hsp_num:0 OXA-491 53.85 3005725 penam antibiotic inactivation OXA beta-lactamase oxacillin MRRLTTLFPSKFLEEHAEELGVVEREGKLQIPVLVWALVFGFAAGESRTLAGFRRCYNSTADETISPGGFYHRLTPTLAEYLRDLVEHGLDEVAVPDTVDADIDRFRDVMIADGTVLRLHEFLSDEFQARHEEQAGAKLHLLHNATDETIERIDVTDEKTHDSTLFKTGSWLQERLVLFDRAYFKYRRFALIDENDGYFVSRLKENANPLITEELREWRGRAIPLEGKQIHDVVDDISRKYIDVEVEAEFKRGQYEGTRSLDTKRFRVVGVRDSDADDYHLYITNLPRDEFFPEDLATLYRCRWEVETLFRELKTQYELDEFNTSDPDVVKILLYAALLSLLVSRELLDLVTEQADDEIVFPPERWAATFRSHAQLILQELGEYLGYSPPPLLERLIEDAQKIHQQRPILQETLATATQPRCES TPA_BK010830.1 DAC79612.1 tpg 134055 135578 + uncharacterized protein Loose gnl|BL_ORD_ID|2720|hsp_num:0 Erm(48) 35.71 3004094 macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin B antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase erythromycin; clindamycin; pristinamycin IA MSPSTPTDDEDMAYRVAALPLEYGETRVNQLFTSGYNRYVVDGEDQPEDLVNDIERFGTAAFKEQVRADAAEEPFVDEPGTLAVLATLSAICVKEHPKFEHASPRNIQVLYDIRELYINNLASLIRAHGDGSLQQDIADVLYSKEPGEDGPHPGRVCTGITEMPELGDGLSLEIPMAAASRKCLVREDEASAGSNDGEEILTRVKDNKLYVPVGDFDSKYRDYAERAFKKLLRVQEDGLSDDQLTWLTTNESAITERIERFLETGHHERIWRNWDRGERTIRVLRQALGDAPDDVAQKGEFHTAKELYRAVAAYDAEDDWESSVTDWISSPSSLAKTLADHESHSAVTIDRDGRVNTYRIGRAGTGAEQIEVREIKDLFELPCMANMEKRLHEKKPVRKDLYNFARMVMWLPQYQDSSLDEIVTDLKDVFSRWPWYDEQETEYQVRYEFSNTIDGDTPLPMNCDNDDLQRYCIGQDQCPYSIWGSLPFPDEMYEQVEEGSAGPTEQF TPA_BK010830.1 DAC79613.1 tpg 135862 136707 - probable arsenite(III)-methyltransferase Loose gnl|BL_ORD_ID|421|hsp_num:0 Erm(37) 31.15 3000392 macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase erythromycin; roxithromycin; lincomycin; telithromycin; clarithromycin; clindamycin; tylosin; spiramycin; azithromycin; dirithromycin; pristinamycin IA; quinupristin; virginiamycin M1; madumycin II; griseoviridin; dalfopristin; pristinamycin IB; virginiamycin S2; pristinamycin IC; vernamycin C; patricin A; patricin B; ostreogrycin B3; oleandomycin MSNDNETMVADRDPEETREMVRERYAGIATSGQDCCGDVGLDVSGDGGCCSDETEASGSERLGYDADDVASVADGADLGLGCGNPKAFAAMAPGETVLDLGSGAGFDCFLAAQEVGPDGHVIGVDMTPEMISKARENVAKNDAENVEFRLGEIGHLPVADESVNVVISNCVVNLAPEKQRVFDDTYRVLRPGGRVAISDVVQTAPFPDDVQMDPDSLTGCVAGASTVDDLKAMLDEAGFEAVEIAPKDESTEFISDWDADRDLGEYLVSATIEARKPARDD TPA_BK010830.1 DAC79614.1 tpg 136700 137059 - ArsR family transcription regulator ArsR2 Loose gnl|BL_ORD_ID|854|hsp_num:0 mecI 20.31 3000124 penam antibiotic target replacement methicillin resistant PBP2 methicillin MVQDATADGVMDASDACCAPPGNVDSDAMATDLQVLSAMGNDTRYELLRRIANADDGVCVCDLEATVGVSQSAVSQALSRLYTAGLVTRRKEGSWRYYEPTETTEVLLETLDDLRGNHE TPA_BK010830.1 DAC79615.1 tpg 137246 137434 - uncharacterized protein Loose gnl|BL_ORD_ID|2227|hsp_num:0 TaeA 28.57 3003986 pleuromutilin antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump pleuromutilin MLLSDVDGVLTAAESLGGALAEAKTERDRDDFEALLEDCTETITEVTGVDYTDASDAGSDCC TPA_BK010830.1 DAC79616.1 tpg 137425 137793 - DUF964 family protein Loose gnl|BL_ORD_ID|1696|hsp_num:0 aadA14 30.51 3002614 aminoglycoside antibiotic antibiotic inactivation ANT(3'') spectinomycin; streptomycin MSESPVETTDVETELEAFVDELLACETYQALVDAREALEADAEAQELLDAYRETERELQDGEFDASLMSDLRDIQDDLSEIESVTRHREAREAFEELLAETNDVVSERIGQEFAQSLGGGCC TPA_BK010830.1 DAC79617.1 tpg 137790 139724 - ArsA-type transport ATPase (probable substratearsenite) Loose gnl|BL_ORD_ID|2680|hsp_num:0 LEN-39 39.02 3004842 penam; penem antibiotic inactivation LEN beta-lactamase MTATQTPAKEVVEPNSEDTEFVFFSGKGGVGKSTVSCATATWLADNDYDTLLVTTDPAPNLSDIFNQDIGHEVTAIDDVPNLSAIEIDPDVAAEEYRQETIEPMRALLGDEEIQTVEEQLNSPCVEEIAAFDNFVDFMDSPEYDVVVFDTAPTGHTIRLMELPSDWNAELEKGGSTCIGPAASMDDKKADYERAIDTLSDESRTSFAFVGKPESSSIDEIERSASDLAELGISSQLLVVNGYLPESVCEDPFFEGKRADEQAVIDRVESTFDQQALATYPLQPGEIAGLELLSDVGGVLYDGEEATVDVDAATRRATNEDTVDFDTFTDADAVAEELVPVEETRYLFFTGKGGVGKSTIASTTAVSLAEAGYETLVVTTDPAAHLADIFEQPVGHEPTSVGQANLDAARIDQERALEEYRTQVLDHVREMYDEKDDTQIDVEAAVANVEEELESPCAEEMAALEKFVSYFEEDGYDIVVFDTAPTGHTLRLLELPSDWKGFMDLGSLTKGAAPANGGKYDEVIETMQDPSRSSFAFVMYPEFTPMMEAYRAAMDLQDQVGIETSVVVANYLLPEDYGDNAFFENRRAQQAEYLEEISERFDVPMMLAPLRQEEPVGLDDLREFGADVTGLDGVGEDDREEVTVS TPA_BK010830.1 DAC79618.1 tpg 139725 140051 - transcription regulator ArsD Loose gnl|BL_ORD_ID|2035|hsp_num:0 fusD 23.68 3003731 fusidane antibiotic antibiotic target protection Target protecting FusB-type protein conferring resistance to Fusidic acid fusidic acid MTQLTLYEEAMCCSTGVCGPDPDDELVEVSAALDQLENEFDVDVSRANMQHNIEQFLETQQIADLVEEHGPSILPITVVNDEIVARETYLSYDELASTFEDSPDPQEA TPA_BK010830.1 DAC79619.1 tpg 140392 140781 + ArsR family transcription regulator ArsR Loose gnl|BL_ORD_ID|2307|hsp_num:0 tetA(60) 38.24 3004035 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MSSTERLQRYLTDERGGCGDEEVAQRLDELEELDAAAGGPALEADVGVLSALANETRYKIIRILHIAGEELCVCEFSPLLDVSDSAISHSLSQLTEAGLVTRRKDGKWRKYQTTMRGDALLVALNGSRR TPA_BK010830.1 DAC79621.1 tpg 141871 142311 + uncharacterized protein Loose gnl|BL_ORD_ID|2361|hsp_num:0 MuxB 31.75 3004074 macrolide antibiotic; monobactam; tetracycline antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; tetracycline; novobiocin; aztreonam; kitasamycin; rokitamycin MASERRSETQSAHHAETIPDDQVSWADLEVVVSTDRDHASVVALVECTLVELTHEPSGAVFVSRQVGQSTRTQYVVADEVGEQFQKRHFDDRLGWHETTVPRRNVRDELIAQLTQSPSTTAGRSGEGAASEPDTFVVKPVRELRTL TPA_BK010830.1 DAC79624.1 tpg 144507 144797 + uncharacterized protein Loose gnl|BL_ORD_ID|2719|hsp_num:0 tet(53) 50.0 3004589 tetracycline antibiotic antibiotic inactivation tetracycline inactivation enzyme tetracycline; minocycline; oxytetracycline MPGPDPHDDTSADHEQFEKEQFAQDRDAAGVDTADIDDATAQRLVSDLVDADIVTPVPEDRVLAHEPSGAAFDSSTQLAVFHRGWTAGRDADAGDE TPA_BK010830.1 DAC79625.1 tpg 144797 145123 + uncharacterized protein Loose gnl|BL_ORD_ID|597|hsp_num:0 AAC(3)-VIIa 36.67 3002541 aminoglycoside antibiotic antibiotic inactivation AAC(3) paromomycin MQQTLVGCAFCDAPPGAEAGEAHTWGQDDRVTHPICVDCAIQTEPNPDERDDYACDGCGLVVDTLAALTRFRVELGHLEGPLQLCARCSPGGLATYWTRDLTEHLVAE TPA_BK010830.1 DAC79626.1 tpg 145165 145659 - spurious ORF Loose gnl|BL_ORD_ID|3287|hsp_num:0 ANA-1 36.84 3006896 carbapenem antibiotic inactivation ANA beta-lactamase MDVIVGGDLSELIDDRRWDDDLVPGETECEWIGVVVSNDAETHEGGGVCDTPRHLCVGDLVDEVLVQLLFQHADVCRFFGADEGFELLEADLVVIISGGDLLGECVVMSGVLEVLPKRGHEDICSVFPEDCGQCVGPIDEPIGGPKLHALLLGAHNVYNVSQPT TPA_BK010830.1 DAC79628.1 tpg 145498 146010 + uncharacterized protein Loose gnl|BL_ORD_ID|1230|hsp_num:0 mtrC 32.43 3000810 macrolide antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; penicillin; azithromycin MSRCIADASALVSLGIVADNDPDPLALCLSRYKVVVPTTVIDELREIASYDDVHGHAASAVLDRVDAFTTQSVDLDAEFPLDDGENAAVTLANDLEAALFLCDEFNQLGLIHASLADTRLVTTPTLLSVLVRTEHLSAADARVLLDAISDARSWDANSYVQRARSLFEEP TPA_BK010830.1 DAC79629.1 tpg 146042 146371 + uncharacterized protein Loose gnl|BL_ORD_ID|450|hsp_num:0 OpmD 35.71 3000809 fluoroquinolone antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump acriflavine; tetracycline; norfloxacin MPDNDALYDVREQTGDPEHASVDDVVELVLERAQHPRTEHRDAHLDEMMATVVDRYGTDPVRTVIQRVLVDHYPFRTATHDLEMHNVDGVRIGTAASQFLTELNAQHDD TPA_BK010830.1 DAC79631.1 tpg 147098 147997 + uncharacterized protein Loose gnl|BL_ORD_ID|327|hsp_num:0 QnrB42 24.04 3002757 fluoroquinolone antibiotic antibiotic target protection quinolone resistance protein (qnr) ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; nalidixic acid; norfloxacin; sparfloxacin MSSNNASGKVVSVDEQAFENAGEQAADEDGFPVVDETPEFEAAVEQETQAKVDANHPDGIADTSEDRIHGVTLEQEERIRAREAELERISAQAELGTQDGREQRTRDIAAKRSAVRRAEFQTRAASVDPMADPERDDPRAELTQEQLAAVNKQSMRLAEKLDGWSRAAIGRRLGEAVVGGKDVTSAVVGVFEELQTAPGTVIPIGKLEDVNRKEVSIEGTVTRLWKPSSAAISQVGLIEDESGKTKFTSWVASEQPWIEEGEHVRIHGAAKNWYNGRVSVALTGWSTVHFPERGRWWEA TPA_BK010830.1 DAC79632.1 tpg 150412 150615 - insertion element protein (ISH2) Loose gnl|BL_ORD_ID|2305|hsp_num:0 tetA(46) 28.21 3004032 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MARTKMGVSIRTELVDELDSLVDECSDLGASRSEIVEAILTAYFQNDEDQIKQTRELIIRNRKRSNS TPA_BK010830.1 DAC79634.1 tpg 153698 153901 + insertion element protein (ISH2) Loose gnl|BL_ORD_ID|2305|hsp_num:0 tetA(46) 28.21 3004032 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MARTKMGVSIRTELVDELDSLVDECSDLGASRSEIVEAILTAYFQNDEDQIKQTRELIIRNRKRSNS TPA_BK010830.1 DAC79635.1 tpg 154707 155144 + TRAM domain protein Loose gnl|BL_ORD_ID|4979|hsp_num:0 FRI-11 30.77 3007632 carbapenem; penam antibiotic inactivation FRI beta-lactamase ertapenem; meropenem; imipenem MVEVPESLQSLFSATVEKRGETYTLEVPQTEVDHGAISPGETYRIGVLTQRQSSTKTADERTAQEQPAPSERNSGPPTPPVTEGEVRDVTIETVGDQGDGIAKVERGYVVIIPGAQPGDEPTIEIDQVQENVAFASVVDTGPQSL TPA_BK010830.1 DAC79637.1 tpg 155237 156067 + DUF4095 family protein Loose gnl|BL_ORD_ID|2198|hsp_num:0 catB11 29.51 3004660 phenicol antibiotic antibiotic inactivation chloramphenicol acetyltransferase (CAT) chloramphenicol MSSTQETQTIRQGLSTRESRLLSHLAAEGHQIISIDDVEATLEVAPNTAREIASRLTEKGWLDRLLPGRYLIIPLAAGEEAVYTTHEYLIASHVAEPMYIGYYSALSHHGLTEQVPRTVYVVTPTRAQSREIHGVPYRVATVTERKFFGYEPTSIEGTVVNVADLAKTLVDCADHPEYCGGIRELATAMVAADDQACSWATVGEYLQRLDNGAATKRIVYLADQLSIDLPTRETLVESFTSGYSLLDPTQSEQGSYDSEYRLRINVDPGTLGPTES TPA_BK010830.1 DAC79638.1 tpg 156073 156876 + DUF1814 family protein Loose gnl|BL_ORD_ID|3156|hsp_num:0 ADC-129 39.29 3006304 cephalosporin antibiotic inactivation ADC beta-lactamases pending classification for carbapenemase activity MISQNRLRVLARELGVRQGYAEKNYVNSWILWGIFTSDFGENLMFKGGTALSKLYFPQSWRFSEDLDFGVEGQYNGSEDDLRDVLDTVTERSGIEFTISEHHESRQQHYPTHYVDMSIQYRAVLDHPNTTSLDVMVDEYVAFDSVHHTHSYEDIPEFELQAYSVEEIFAEKLRAIFQRGAARDYYDLYQLLETESVEIEFDVVLPAFEAKCDHDDLDVDLTTGLPGDQREDIQRQWETSLPDLTGDPPLFDTVWKRLDEAVIDKGTE TPA_BK010830.1 DAC79639.1 tpg 157138 158076 + ParA domain protein Loose gnl|BL_ORD_ID|2140|hsp_num:0 ANT(4')-Ib 35.14 3003905 aminoglycoside antibiotic antibiotic inactivation ANT(4') dibekacin; amikacin; tobramycin; isepamicin MAGTNSGNSIDSTNSPNSPYDSVDTAGNSRAVSVCMLKGGVGKSTIAVNLARQLATHDHDVLLIDLDPNGHASVGLGFDDHYHNTDEGIGEVFFDEADPTSVVYDTEYEFDILPSSEDLEQVEREIVVGDVFQPSALLKREVVEPLLGDEYDFIVTDSPAYRSRLTDNALVATSNLVLPLAPGNEAMSGLERTIERQIAPLRKHMDVDVLALVPNMLDGRIDQQTQDRQLLERLNSHNSLQDRIPNFARITDWEAVGSGDISPTPGIRDRTSITKAYGERKPLLDYDANCDQLKNFDELAHIVEAGEVVRHG TPA_BK010830.1 DAC79640.1 tpg 158069 158488 + uncharacterized protein Loose gnl|BL_ORD_ID|2563|hsp_num:0 OXA-156 31.34 3001461 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-62-like beta-lactamase oxacillin MADDGDPFADLSQTLDDDADDQDETKSEQEPREPPASDTTTEHVDEPDEGDVEELDPMTDTAFSYEAANQRPFYAREETIENFDSWLNYELERELSTRGYQNIVVREMTDALLRTVVEEDLVDEVAERFEQERKNAISK TPA_BK010830.1 DAC79641.1 tpg 158722 160146 - ISH10-type transposase ISH10 Loose gnl|BL_ORD_ID|2673|hsp_num:0 MCR-7.1 30.3 3004517 peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase colistin A; colistin B MVIVDRDDLSKDELLSRFLQMEERIDELEEKLEQKDERIEELETRLRKYENPHTPPSKRRSGTDESPTSQDDEDDDVRTDGGTPGRKDGHDPEWRSTTDPDEEIEVTCDCCPECGDHFDESVGVSPRLVEEIPDPQPPEITRYNRHYYQCDSCGTETVAAHPDCPDEGQFGVNVIAQSALSRYDHRLPYRKIADRFEQLHELELSGASAWHATERAARAGRCEYEQIRREIQDADVVHIDETGIKRDGEQAWIWTFKTAQHTLYAVRESRGSDVPAEVLGEDFAGTVICDGWTAYPAFSSNLQRCWAHILREAEDAAEKQAEGEPIYHALRQVYVALQARLESDPSPRERADLQRVARRELESLIERSVPDGPVATLLGKIEGGLDHWLTFVGEPAVSPTNNAAENALREPVVLRKIIGTLRNDRGMFVHETVLSLLATWRQQGRNPYEELRRVVSSNEMLSRAHAVPAVETSG TPA_BK010830.1 DAC79642.1 tpg 160541 161098 - uncharacterized protein Loose gnl|BL_ORD_ID|1876|hsp_num:0 TEM-60 25.27 3000929 monobactam; cephalosporin; penam; penem antibiotic inactivation TEM beta-lactamase ceftazidime; ampicillin MYTANIADTVMFRNLGKHPSPHLQSLKSAVEEAGTEVWVPAAVYHELADTGSADSPTNPYLDTAIEEGWLRVATPLPGDRTAGFESSAGPVEKARFVADEFLNQQSKYPETNNWQDAAVVALAVRLFDANARIRVITHTADENLAKACARIPPEFGYYDIKSRYYNPPQTAKVEFPTVGQLTWSE TPA_BK010830.1 DAC79643.1 tpg 161110 161763 - TrmB family transcription regulator Loose gnl|BL_ORD_ID|4986|hsp_num:0 PSZ-1 25.0 3007648 cephalosporin; cephamycin; penam antibiotic inactivation PSZ beta-lactamase cefoxitin; cefazolin; amoxicillin; benzylpenicillin; ampicillin; cefalotin MVSSFVTLHKMSYDTEHVRNAGDTPGTITGIPTFAELLENPSLADLYTSIRQAETATGPELVETTTVSKKTVYDYLHKLEQAGLISKVGDETGTAVYTAQEFELTLTVRETEVSITPKIIEVIAQKNEYPAIERVLEDYGIVTFALAYDLVNAHSEGEVTIRQIASLTDLSPGTTYDLVEALYSVLDLGDDDSTPTTYTPDEFDAEGGDLLEEYADK TPA_BK010830.1 DAC79644.1 tpg 162049 163131 + isopentenyl-diphosphate delta-isomerase%2C typeII Loose gnl|BL_ORD_ID|3890|hsp_num:0 OXA-640 25.37 3005861 penam antibiotic inactivation OXA beta-lactamase; OXA-184-like beta-lactamase oxacillin MTAQDSTQTEDRKDDHLQIVQERDVETTGTGFDDVHLVHNALPELDYDAIDPSIDFLGHDLSAPIFIESMTGGHHNTTEINRALARAASETGIAMGLGSQRAGLELDDERVLESYTVVRDAAPDAFIYGNLGAAQLREYDIEMVEQAVEMIDADALAVHLNFLQEATQPEGDVDGRNCVAAIERVSEALSVPIIVKETGNGISGETARELTAAGVDALDVAGKGGTTWSGIEAYRAAAANAPRQKQIGTLFREWGIPTAASTIECVAEHDCVIASGGVRTGLDVAKAIALGARAGGLAKPFLKPATDGPDAVIERVGDLIAELRTAMFVTGSGSIDELQQVEYVLHGKTREYVEQRTSSE TPA_BK010830.1 DAC79646.1 tpg 163498 164772 - ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|2034|hsp_num:0 vanJ 30.0 3002914 glycopeptide antibiotic antibiotic target alteration vanJ membrane protein teicoplanin MRRLTTLFPSEFLEEHAEELGVVERDRKLQIPVFVWAFVFGFAAGERRTLAGFRRSYNSTADEPISPGGFYQRLTPTLAEYFRDLVEHGLDEVAVPDTVDVDIDRFSDVMIADGTVLRLHEFLADQFEARHEEQAGAKLHLLHNATEQTIERIDVTDEKAHDSTLFKTGSWLENRLVLFDLAYFKYRRFARIDENGGSFVSRLKQNANPVITDELREWRGRAIPLEGKQLRDVLDDLDRTYIDVEVEVEFKRGPYNGTRSLDTKRFRVVGVRDEDADDYHLYVTNLSREEFFPADLAQIYRCRWEVELLFRELKTQYDLDEFDTSNEHVVKILLYAALLSLLVSRDLLDLVTEQADDELVFPPERWAATFRSHAQLILHELGEHLGYSPPPLLERLIEDAQKIHKQRPILQETLATATQPRCES TPA_BK010830.1 DAC79647.1 tpg 165037 165417 - uncharacterized protein Loose gnl|BL_ORD_ID|131|hsp_num:0 cpxA 63.64 3000830 aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump neomycin; amikacin; kanamycin A; tobramycin; novobiocin; gentamicin MVSGWQVIRVACILSVSVGVGLLAISISLGLTAGTAPPVLVGFGGSVCTAYLLLRKHPNIETGPLWRFSGLVFVLFILGNAVSTEGIYAPQSEQSPLAIGGVWALSLLICYTVIFKVEWTNRSPSQ TPA_BK010830.1 DAC79648.1 tpg 165791 166033 - spurious ORF Loose gnl|BL_ORD_ID|2378|hsp_num:0 ANT(3'')-IIa 37.5 3004089 aminoglycoside antibiotic antibiotic inactivation ANT(3'') spectinomycin; streptomycin MVVAGIEVLVAASTGDDFAVVHDGAFGDRASFDVLVGYRRSLWDFHCSCLREGGHPLSSGLFYCSKPNQLQRSEITAFGL TPA_BK010830.1 DAC79650.1 tpg 166116 166565 - spurious ORF Loose gnl|BL_ORD_ID|1011|hsp_num:0 AAC(3)-VIa 31.94 3002540 aminoglycoside antibiotic antibiotic inactivation AAC(3) sisomicin; 6'-N-ethylnetilmicin; gentamicin MGALVDVVEQSFASIGSPELLLDVVALRREYFFGGGRRERVLADLTAALPPAKRGAREREIRPDGVRGEIVFFHEVDNPISSVLFVDVRDGVDIVVLGEELEQIVDGDPRDLLGLWAFEGDHAVVEEGFEAANPRGSVVIRHLNHASTR TPA_BK010830.1 DAC79651.1 tpg 166140 167258 + XerC/D-like integrase Loose gnl|BL_ORD_ID|1374|hsp_num:0 ACT-4 40.62 3001829 carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation ACT beta-lactamase MSNNDATPGVRGLETLLDDRMVSLESPQTQQITRVAVNNLFQFLTENNDVDSVADVDEQDARDWVIHLVKEDDLAANSIRTYFALARATFGWWQRSGEIGQNPLATTTAEEVLPSKSNDVEQQFWTADARERLLNYVDERAHAALENDSSDAARAFRDRSLVYILADTGVRGAEICSVSRDNRRNGLRWTDVDLEAGVMTVLGKSGDQESVSLPGVTSEKLARYRRLVDAPAEWPVIPTGDATSKYRAVRKQLREREYGDEAIEGVLEDCEIDEVLREYEVAPPALTTEGARTLLKRLCGEADVDIDGDYLKPHGGRRGLGDELYGEVAAESAQEVLRHKSIETTHASYRERRAEDLSADIEKVRYSNTDEE TPA_BK010830.1 DAC79652.1 tpg 168532 168891 - thioredoxin Loose gnl|BL_ORD_ID|2297|hsp_num:0 Pseudomonas aeruginosa CpxR 34.55 3004054 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump neomycin; erythromycin; amikacin; ciprofloxacin; kanamycin A; tetracycline; tobramycin; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; gentamicin MATDTAATTGTASPDEPLYVNGQTELDDVTSDNDVVLADFYADWCGPCQMLEPVVETLAEQTDAAVAKIDVDENQALASAYGVRGVPTLVLFADGEQVEEVVGLQDEDALKDLIESYTE TPA_BK010830.1 DAC79653.1 tpg 169067 169471 - TrmB family transcription regulator Loose gnl|BL_ORD_ID|810|hsp_num:0 APH(6)-Ib 32.26 3002658 aminoglycoside antibiotic antibiotic inactivation APH(6) streptomycin MPDSMSEQLRQDMECEGLLECFHGLKELDKECFQALVEAEEPMTVDELAEAVDRERSTAYRAVQRLLQTGFIEKEQVNYEQGGYYHVYSPSDPSQITDDMQRMLNDWYAKMGQLIQEFETKYEQPDSVPQSAES TPA_BK010830.1 DAC79656.1 tpg 170951 172216 - major facilitator superfamily transport protein Loose gnl|BL_ORD_ID|1484|hsp_num:0 tet(41) 24.77 3000569 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MSTTTELRQGIREHLGQFSLHVLLVFATGLTIGSERTVVPVLGEDVLGVESFLVIGSFVVSFGIVKSILNLYAGKWGEAYGRKPVLIAGWATALPLPIILIFAPSWGWITVGNVLLGINQALTWSMAINAKIDLAGPDQRGLAVGIDEAFGYTGVAVGAWITGVIAGQWSLRPEPFYFLAVVVVLAFLISIFLIKETVQYAQAEGNDDHHDANLPFNEVLKRATYGDRTLFAAAQAGHIENFVDTLFWIAVPLYLTSQGLGIAAVGVVVGVHSAMYFLQIATGGLADRIGRRPPVVAGMFLAGAGVLGMVLVDGYLPWAVLAGVSGLGMALLYPNLMTVPSDAAHPTWRSAGMGVYRMWRDSGYAVGAVLIGLSMEFVNAAAAFYLTAGLMFASGAVVYVWMEETHPDFGTHEPPAPAPSD TPA_BK010830.1 DAC79657.1 tpg 170999 172249 + spurious ORF Loose gnl|BL_ORD_ID|4732|hsp_num:0 vanR gene in vanN cluster 22.22 3002929 glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanR vancomycin MGLLHPNVHYCTRRKHQARSQVKRGCCIHELHRESNQDRADSVAGITPHPVDAHPRRPPSRVSCVARNRHQVRVQQRHPEPGDPSQDGPREVAIDEHHPEDARAREEHPGNDGRTAADAVREPPGRNLEEVHRTVDTDDDPNRRDTEALTRQVQRDGNPEQCIDEVLYVAGLRRREQRPVAVRRALQHLVERQIRVVVVVVTLGLGVLDGLLNQEDGDEERQYDDHGEEVERFGPQTPLACDDTRDPGADSDASVAERLVDADREPALVGTREVDLRVDRHTPRQRLVDPQQDVPDRDPAPARGEDEDDRQRERRRPSGDEDGFATVRLAPLAGVEIEDRLHDPERDDERADHKERLDAEDVLPEYGDDCPFGTDGQAGREDEQDVQRELPEVFADPLAEFSGRTHGLLGRTVVWA TPA_BK010830.1 DAC79658.1 tpg 172220 173329 - rhodanese domain protein / beta-lactamase domainprotein Loose gnl|BL_ORD_ID|1587|hsp_num:0 IND-4 25.81 3002260 carbapenem antibiotic inactivation IND beta-lactamase MQELSPAELGEQVQDDDGPLVLDIRHEEDFQEWHIPGSRNVDVYDELTDDPEQAIEPLDDLPSDEQIVTVCAAGVVSQTATAVLRELGYDAVTLTDGMNGWSRVHRHAELPVDVDGTLVQVARPGKGCLSHVLVSDGEAAVFDPSHYLNEYDTVLDEYDAELVGVFDTHAHADHVSGAADLADRHDVPYYLHQKDALAVDATPLEDGQTVTVGRLDIEVIHTPGHSEGSVSFDVEGAALLTGDTLFHDSVGRVELGVEAGIEDADVEGNAATLYESLQRLLDRPDDALVLPAHDPGSPEPPVAATLAEVRERNDDLGRDREAFVEELASDIPDHPPNFERVKRTNVGQESVPEEELAELELGPNNCAAE TPA_BK010830.1 DAC79659.1 tpg 173377 174153 + HTH-10 family transcription regulator Loose gnl|BL_ORD_ID|2576|hsp_num:0 ADC-164 40.54 3006336 cephalosporin antibiotic inactivation ADC beta-lactamases pending classification for carbapenemase activity MTGTANYVEFEPTRMGLYEASIRVKHECPYRRISERYPDLTIREWPLSDCQVLEITTETTPTDELLDEINEIGTVLYESADDNGYHVVTQSCLCSLEDSVIDRFEEHNCLYQSPTIYRQGWEHYTVVAFDSEDVRELLDSLRSDREIELLSKTSISETQIPHSMLAPANQLFEDITDRQLAALQLALESGYYEQPRKTSLRDLAERTAVARSTYEEHLRKAENKLLTNAGQFLRLVTATSTTNPLGVESGRRTEQTAD TPA_BK010830.1 DAC79660.1 tpg 174170 175345 - transport protein (probable substratephosphate/sulfate) Loose gnl|BL_ORD_ID|2428|hsp_num:0 rpoB2 37.78 3000501 rifamycin antibiotic antibiotic target alteration; antibiotic target replacement rifamycin-resistant beta-subunit of RNA polymerase (rpoB) rifampin; rifaximin; rifabutin; rifapentine MDPALIALFAGAALASLFMAWVIGAGSSGATPYAPAVGANAISTMRAALLVGIFGFVGAVTQGGNVSEAIGSGLVGGISLPIAGVILVLVLGAGLMAIGITTGYPIATAFTVTGAVIGVGLALGGSPVWPKYQQIAAVWVLTPFVGGGIAFTIASLLPRPGVPERYSIPVLAGLVGAVLVNIQFSFLGAGSAAGTVRGVGQRVLAVDGLTSAVGITGFAALVVATVVWWDVSRDERGGLRRVLLALGSLVAFSAGGSQVGLAVGPLLPLLDEVGMVSTFAVLVGGGLGMLVGSWTGAPRMIKSLAQDYSSLGPRRSISALVPSFLIAQLAVLLGVPVSFNEIVVSAIIGSGAAVGGREAVDARKIGVTIGAWIGSFALSFALAYAAGALLL TPA_BK010830.1 DAC79662.1 tpg 175356 175814 - DUF4341/DUF395 family protein Loose gnl|BL_ORD_ID|467|hsp_num:0 tetA(P) 21.62 3000180 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MSDRHPAFMPLILVGGLIFGFGLAYSQMARPEVVLNFLQFEDFGLVFVMFGGAAVTGVTFFVAPRLLGRAPLTGDSFQRRLKSFDRNVLIGGAIFGVGWGLSGICPGAAYASLGIGNITILWALAGMFLGAYTQGFWRSHSQSRDASSAGAD TPA_BK010830.1 DAC79664.1 tpg 176314 177507 - rhodanese domain protein / beta-lactamase domainprotein Loose gnl|BL_ORD_ID|3333|hsp_num:0 CAR-1 35.11 3006903 carbapenem antibiotic inactivation CAR beta-lactamase MNADDFPTPDADVESVDPESLKDRIDAGEDVTLLDARMTSDYEEWHIDGENVTSINVPYFEFLEDDIDEDVLDQIPDDREVTVLCAKGGASEFVAGTLAERDYDVDHLEDGMNGWARIYDAVEVEGYDGAGTLLQYQRPSSGCLGYLLYDDGEAAIIDPLRAFTDRYLDDADNLGVDLQYALDTHVHADHISGVRNLAEEDIEGVIPEAAVDRGITYADDMTTAADGDTFDVGDATIEAVYTPGHTTGMTSYLVDDSLLATGDGLFIESVARPDLEEGDDGAPDAARMLYESLQERVLTLPDDTLVGGAHFSDAADPAADGTYTAPIGELVDEMDALTMDEQAFVDLVLSDMPPRPANYEDIIATNLGQNAVDDEEAFTLELGPNNCAASQDSLAGD TPA_BK010830.1 DAC79665.1 tpg 177757 178002 + UPF0033 family protein Loose gnl|BL_ORD_ID|741|hsp_num:0 mecC 41.38 3001209 penam antibiotic target replacement methicillin resistant PBP2 methicillin MSADYDITETLDVKGASCPMPVVKTKSAIDDLAEGEILEVLATDSGSMSDIDGWASGTAGVELVDQEEGDDVYKHYVRKTK TPA_BK010830.1 DAC79666.1 tpg 178005 178577 + DsrE domain protein Loose gnl|BL_ORD_ID|4843|hsp_num:0 MCR-4.6 38.89 3007231 peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase colistin A; colistin B MSTDTPDASVDDAPSRAELAARVNELEDALAEATSEDDAKKMSIISTKGTLDMAYPPLILASTAAAFGYEVTVFHTFWGLEILHEERSKNLKLSSVGNPNMPVPNAVAALPGMDRVTTKMMEKKIDDNDTATIEELIETSLDMGVEFQACQMTIDLMDYDEDDFYDGVTTGVGAATALQDMAEADIQLLV TPA_BK010830.1 DAC79667.1 tpg 178696 179691 - cytochrome bd ubiquinol oxidase subunit II Loose gnl|BL_ORD_ID|1197|hsp_num:0 mef(B) 44.19 3003107 macrolide antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump erythromycin; azithromycin MTDPLIPVDTYLVDSLPEVWFGAVVFALGMYIVLDGFDFGIGMLYATRTDEHERETFLAAFGPVWDANEVWIVAFGTMLLAAFPRVYSRLLADNYLLALGFVVALVFRGLGPELREQREDERWKRYTDYAFVGGSVFAPLLLGMLAGRWLFAGATLPVVLTGVGLVAVSIVTGAAFLAAKTDSGLASELRSYGVGATVAYLGGVVVLLGTVVATDAGGAASAVLSLPVAAVVALSIVAGLGGSVLARRGRYRAWLASALALPTLLTLLVAVLLYPTVYPPTGLLVREAVVSPLALNLVTVLGFPVLLLVLWYFKFLYGVFSGPIEGEGYGG TPA_BK010830.1 DAC79668.1 tpg 179684 181132 - cytochrome bd ubiquinol oxidase subunit I Loose gnl|BL_ORD_ID|3409|hsp_num:0 CRP-1 25.97 3006868 carbapenem antibiotic inactivation CRP beta-lactamase MVPATLLSTVDLGWMALLSPEIASRMQFGWTISVHIIFASLSIGLAPFIIYFTWKDVRTNEQRYARLRSFWVKVFAVGFVMGTVTGIPMSFQFGTNFPQFATIAGELIGGPLAFEAKMAFFLEAVFLGVLLYGRERVADRTYVLSSVLVGVGAWLSGFWILVVNAWMQTPRGYEMVTRNGMEVAKLTDPVAAFLTPRMPWMYVHMMNASVISVALLVAGVSAYLVWKKPDADAWNSALKLAVVLLLVSAPFQAVHGDAYGRHVEDTQPQKFAAMEAHYETGSADLHLLAFPKSLDALTDPRTENLFTVSLPGIGSFLASGGDFDAEVIGLNEYEENPPVALVFWSFRFMVGLGFLFIGLALWGGYLTYRGRLTESTRYLKSMIAASPFGYAALLTGWYVTEIGRQPWVIQGELKTSEAVSSTLTGTEATLTLVGFVVLYIALILTALYVLKWLIRGELRSLGVQESSAGRWRGPLPWVTSDD TPA_BK010830.1 DAC79670.1 tpg 182187 182570 + uncharacterized protein Loose gnl|BL_ORD_ID|4680|hsp_num:0 vanS gene in vanF cluster 30.43 3002936 glycopeptide antibiotic antibiotic target alteration vanS; glycopeptide resistance gene cluster vancomycin MFTVDETYDGFEFTLRNQTTASLTITRTKAWEIERHTSDGWEQVATEVGVAEGKTRTLDCGEAHSWHHALFEHPTLPSRKTTYLFENLSEGLYKFSVTGNLETGVEITRETQFEVQRQLPPQTKTDE TPA_BK010830.1 DAC79671.1 tpg 182642 182812 + small CPxCG-related zinc finger protein Loose gnl|BL_ORD_ID|3290|hsp_num:0 AXC-3 40.0 3006899 carbapenem antibiotic inactivation AXC beta-lactamase MGENCDKCGTELGSSQERHQRYRIEHPSDSVETLEGRLCSDCFWELKEWLETEEVT TPA_BK010830.1 DAC79673.1 tpg 183604 183885 - PadR family transcription regulator Loose gnl|BL_ORD_ID|2039|hsp_num:0 mphG 28.57 3003742 macrolide antibiotic antibiotic inactivation macrolide phosphotransferase (MPH) erythromycin; clarithromycin; azithromycin MHDLTGFQRDILYVIADFEEPHGLALKDELEVYYEQEINHGRLYPNLDDLVDKGLVEKGELDERTNSYTLTQRGHREITARRDWEQQYVDLSE TPA_BK010830.1 DAC79674.1 tpg 184018 184185 + uncharacterized protein Loose gnl|BL_ORD_ID|4666|hsp_num:0 vanS gene in vanB cluster 45.83 3002932 glycopeptide antibiotic antibiotic target alteration vanS; glycopeptide resistance gene cluster vancomycin MSDLIVKAAVKDELSEHNVSADFYAALNEEVAELLDDAADRAEANERKTVQPRDL TPA_BK010830.1 DAC79675.1 tpg 184489 184710 + uncharacterized protein Loose gnl|BL_ORD_ID|2305|hsp_num:0 tetA(46) 33.33 3004032 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MNYPSLRGYGAVLVVGVAVICMGVIALGFIMPTRLFESTVGLVAFFAAALLMVICAVVANFYDLREVLHEEFG TPA_BK010830.1 DAC79676.1 tpg 184869 185138 + uncharacterized protein Loose gnl|BL_ORD_ID|2347|hsp_num:0 basS 41.46 3003583 peptide antibiotic antibiotic target alteration; antibiotic efflux pmr phosphoethanolamine transferase polymyxin B MSQNTVNTTVSIKPADALFLSWATGTNASGLFREAVAEQMMYRDIDRDELSTLTEEALTETSRDLDDLLEQTSSIEDLNTLLETDPASD TPA_BK010830.1 DAC79677.1 tpg 185578 186570 - ISH11-type transposase Loose gnl|BL_ORD_ID|4561|hsp_num:0 RAHN-2 35.29 3006980 cephalosporin antibiotic inactivation RAHN beta-lactamase MSPATLQDDPSVDSFFNVVETETLALFEHLSFEFLEEFDVFAPAETGRTRDHEPPELMRGFLHCYYKDIYGIRPVERELRNTVVWLSCGFDRPPSRDAVDRFLTDLEHVVNKVFDHLVEQAALRGLLDLTYCIDSTDVRAMPADQDASKCYDPTDDEYYHGYGCTIVSTGQKIPIAAEFTESKQAPEETAMRVTRDALAVAKPIWMVGDSAYDTLDWHDHLLAAGVVPVAPYNARNTDDPKDIEYRVEDRIEQHSEDVQLKQSTLDETYNRRTGVERTNESVKDCGLGRTHARGRVHARAQVFLALCLRLVVAITNYERGDNPGSPIITV TPA_BK010830.1 DAC79678.1 tpg 188028 188855 - ISH9-type transposase ISH9 Loose gnl|BL_ORD_ID|1560|hsp_num:0 Erm(39) 38.46 3000602 macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase erythromycin; roxithromycin; lincomycin; telithromycin; clarithromycin; clindamycin; tylosin; spiramycin; azithromycin; dirithromycin; pristinamycin IA; quinupristin; virginiamycin M1; madumycin II; griseoviridin; dalfopristin; pristinamycin IB; virginiamycin S2; pristinamycin IC; vernamycin C; patricin A; patricin B; ostreogrycin B3; oleandomycin MSKISRFTKKAVQLAKNAVGGRGEVAAPEGGGGFADYAIVSLHCLRVYLEKSYRETLDLLSEMPHILAEIGLNEADLPDHSTLVKAFDRLKTALWRVLLRLSAQLHDPSGHAAIDATFFDRETASKHYCRRTNYRVQTLKTTALVDTETQAILDVHCSTGKPHDTQLGWQVARRNAGDLASLAADKGYDWMELRKKLREDGVRPLIKHRIFRPIDHAHNARVDGPRYRQRAMCETVFSTIKRTLGDAVRARAWFREFREIVLKCVVHNIKRAVTP TPA_BK010831.1 DAC79680.1 tpg 834 1172 - uncharacterized protein Loose gnl|BL_ORD_ID|3823|hsp_num:0 OXA-572 39.39 3005794 cephalosporin; penam antibiotic inactivation OXA beta-lactamase; OXA-22-like beta-lactamase oxacillin MASPTGDDLDGVNEAKKYPDGTVVRVFCMRTNRDTYPSGWAYKLHYGATEPDPPHTLDDGTIRRYDNSHEDTKGHELHVAPDPDPNIIEFPGMVELWERFWSEIPKSQFEVT TPA_BK010831.1 DAC79681.1 tpg 1905 3719 - ISH7-type transposase ISH7 Loose gnl|BL_ORD_ID|2479|hsp_num:0 ACI-1 22.98 3004359 cephalosporin; penam; penem antibiotic inactivation ACI beta-lactamase penicillin; ceftazidime; amoxicillin; cefotaxime; ticarcillin MTFREMVDGALKTYPREQQVRHNRSVTLEDLVTEVPVTYLRFYDEYDHDQGHPKPWGAVFRAHVLRCVKGWKNATALHRYLKQQPFLCTQLGFKDIPDQSTLYRAWDDRLEDVHDAVRDAAEVVVDIARYHDIPAPEPEFLPDQPTDTVTNSKSKDTLAREKAREVWKGAKPIVEDAFHLDRSDNASIPEGAFWEQQSYLGMRTDMHPNDGAQSFAADSTRRKTPSGDSHRLQTKTLGVERIRTMLRETGRTLVARAKSKDKMGRKQMTAIDFTKGNPWSGHVERDSSGQNQEPWILGYKGDDGPFFQWAVIKLVGHDVPLILDAVPVVRGRKRADIVDDLLEGATDIVPGLDLVMMDREFAPDGVKDVCETHDVHYLNPGVVRSSSDHEHQIAKLASEDKDFDVIKQERLDDGPTRKAVYLPKREWEREDEDNDGTDVTIRQELIEDFKDVGNTTPLSEDRDGDSPLSNLLNEVAEEEEIDEPARVEAPTLPFETNLPWVDVDPADQQEMKHQIGRLMARYKRRWGIENGFKKLKTFLAETQSPDHRFRYFNFAFACVLYNCWRLVDILVQLELYGEIGDQPAVSSNSFLTFAKKSYGLDPPD TPA_BK010831.1 DAC79682.1 tpg 4096 4218 + uncharacterized protein Loose gnl|BL_ORD_ID|1764|hsp_num:0 BEL-3 34.48 3002387 monobactam; cephalosporin; penam antibiotic inactivation BEL beta-lactamase MEQIGSNMESMYSILSANTDTFERDATQEVNSKQDSPVIL TPA_BK010831.1 DAC79683.1 tpg 4215 4610 + uncharacterized protein Loose gnl|BL_ORD_ID|35|hsp_num:0 golS 35.9 3000504 monobactam; carbapenem; cephalosporin; cephamycin; penam; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump chloramphenicol MSELPENIQRQKRNGYLMLVGAVFTFGVTAATVQYYELSPISYLGGLVPAGILVFFGYRAVSAGRERKALGDERTQQLYGKVGINSFWILMSVIMVDMAFSIFPEDSATSIYVWIGLACYGLYFVYYRYVE TPA_BK010831.1 DAC79684.1 tpg 4614 4811 + cro/C1 family transcription regulator Loose gnl|BL_ORD_ID|4730|hsp_num:0 vanU gene in vanG cluster 26.53 3004253 glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanU vancomycin MENELKVYRAKHDLTQEDLAKEVGVTRQTINALEAERYDPSLELAFKLAIYFDCSIEDIFSYDSD TPA_BK010831.1 DAC79686.1 tpg 7861 8661 - integrase family protein Loose gnl|BL_ORD_ID|3533|hsp_num:0 FRI-10 25.37 3006227 penam antibiotic inactivation FRI beta-lactamase MRRQAVPLHKKRHYHILNAIHEHPNDDKAMSVHLGIGTGMRNNTIGHVYKDWFFYDSDGNLYIQIPGSDKCRKGNGDGTCGHCEDGGQYNPKTEAGDGRIILIPNSWHNHANEGEEEYFGLKDHVEAYFALDGKNAPDNVRYGKDMIQGNGVSKGPLNKWVRDVAAKSAIQPQLRMKRLEQAGVPNGNGEDEPKKIKDFGHDDEGNKIPDMIFHDLRACYCTQLMRNEVPPHKAINKTGHADPDSLKPYVMFAANEIDAKEEQQWY TPA_BK010831.1 DAC79687.1 tpg 9402 12431 + plasmid replication protein RepH Loose gnl|BL_ORD_ID|2055|hsp_num:0 Clostridium perfringens mprF 42.42 3003773 peptide antibiotic antibiotic target alteration defensin resistant mprF defensin MHTPNQQQGIRKIVPGGTLSTAGITITEVTPRVTEWIPDLLEELLPRSIQSVRKFIRQEDPEVLTHARYNTVYRRLQEETLRFDHQEWCSTTDIWSDAEAEAVEYVESLVEFAVKYSDVDEDDLDELSEYHQQRCKSLKQTLTTISTGRGPLNAGLEALAKGPVRLHDELDDAPQPITLVLDGELWSKLDDRGTGIRALAAIAVLGSTFDVRLVISPALDAAIERRYPDWYDSHLRLTETRETSSVESAGGDGQPSAEQLEEAWEAIQNLPEESGRLRLLRNLPIEGSRDYRDLKQDDEIDVQAGTVGRYILDLEELGLVDIDRRGQYNSASLTGLGQVAVEQYVTTDYRVIHPTQSTLETHLTPTPQPQASTVYPARSDTREGDQPGTAEDWIAATGSPSEGADYVQWLDGPSGVLDAWGMHQRYLAGRRDRGVTLVDDRIERFEDGRVSYLSCFDDDLFVATQWGGPLPTLGRIAGALLSDKALSKILTPSRLGNQFEEINDAVVEQLDREAGEIIRRGHQIGWFSEDEEDYDGWRERIGSVRSLCLQQVGELTNSDDVEARTELLRDLHGLVASATQLYYAAGVDVTINVRVPDTGMLISDERRLDDFLGFARYTIPKQSVYGIHSGYRMLLEDRPEKLKRRLPYEVDDADSTMHLTASWVFSGSTMIDLHDDIEDAIEMETNEIREAIANGQESAPVMEIPVQIGNSYSAIRNHVEDYASAKNYQVAHQEDIHEGKQDLERLVRLFLRVLGTEDRPHRACPHDVAEAMLHVAQSSRNYDFITVRDISYGLSNLPTKRLLPELPPTATKLLKTLLDADDPMGRSEIIDTADISESSYDRYINELAAWDIIEPREIEGHRRWEAHLEPWWTPQSDRDEPYADPDPDTGILYAEFPRDVASAVMCHLITHYDLPDLETAYLEGIQPGDDIKALFDDHDRLRRWRPFLWGAFADSDKLERGPSGTAASDSTVVRLGQSPGPDTAQSSFQDVSETATQRDRLSQPSPGLD TPA_BK010831.1 DAC79688.1 tpg 12847 14013 - ISH3-type transposase ISH3 Loose gnl|BL_ORD_ID|3042|hsp_num:0 OXA-653 39.53 3005342 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-24-like beta-lactamase oxacillin MSTTQQADGEIHEDQLLNFLVNALDEEVALTLAENAEIDAEDIYEVLVGACADGTSVSTLCEKSEDAPHENSVLYHLRTKFDLETLEQVGNALLQKDVLDVLPQQVEVVSDLHLRPYYGDEDGTDGLYHSQAKRGTTAFHAYATLYARVKNKRYTLAVRRLEDGDTASSVLAEFLGILDGLDLDVKAVFLDREFYDSKCLTLLQAHNHAYVMPIVRWGQTIKQELSEGWSRVIQHDMTAKLDGHSWTVEFLVYIDCTYQNGRCDEHGVARHGYAADAPFIESPRDARYHYAKRFGIEASYRLSEQSIATTSTQNPVVRLLYVVVSLLLQNVWRYLHWEYVATPRRGGRRLWKWSFKEFINMIQRAAWTALATRRAVPANRPPDDRFTR TPA_BK010831.1 DAC79689.1 tpg 14308 15582 + ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|2194|hsp_num:0 catII from Escherichia coli K-12 39.53 3004656 phenicol antibiotic antibiotic inactivation chloramphenicol acetyltransferase (CAT) chloramphenicol MRRLTTLFPSEFLEEHAEELGVVERDRKLQIPAFVWAFVFGFAAGESRTLAGFRRCYNSTADETISPGGFYQRLTPTLAEYLRDLVEHGLDEVAVPNAVDADIDRFRDVMIADGTVLRLHEFLSDQFEARHEEQAGAKLHLLHNATEQTIERLDTANEKTHDSTLFKTGPWLENRLVLFDLAYFKYRRFALIDENDGYFVSRLKQNANPLITRELREWRGRAIPLEGKQLRAVLDDLDRKYIDVEVEVEFKRGPYNGTRSLDTKRFRVVGVRDEDADDYHLYMTNLVRKEFFPADLAQIYRCRWEVELLFRELKTQYNLDEFNTSDEHVVKILLYAALLSLLVSRDLLDLVTEQADDELVFPTERWAATFRSHAQLFLHKLGEYLGYSPPPLLERLTEDAQKIHKQRPILQETLATATQPRCES TPA_BK010831.1 DAC79690.1 tpg 16451 16705 - gas-vesicle-associated protein GvpM Loose gnl|BL_ORD_ID|2778|hsp_num:0 ArnT 72.73 3005053 peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase colistin A; colistin B MEPTKDETHAIVEFVDVLLRDGAVIQADVIVTVADIPLIGISLRAAIAGMTTMTEYGLFEEWDAAHRQQSEAFTTSPTADRRED TPA_BK010831.1 DAC79691.1 tpg 16705 17550 - gas-vesicle-associated protein GvpL Loose gnl|BL_ORD_ID|2077|hsp_num:0 AAC(3)-IIe 28.45 3004621 aminoglycoside antibiotic antibiotic inactivation AAC(3) dibekacin; sisomicin; netilmicin; tobramycin; 6'-N-ethylnetilmicin; 2'-N-ethylnetilmicin; gentamicin MTDHRPSPEEEQTTANEERTVSNGRYLYCVVDTTSSESATLSTTGVDDNPVYVVEADGVGAVVHDCETVYETEDLEQVKRWLVTHQQVVDAASDAFGTPLPMRFDTVLEGGDASIERWLEDHYEGFRDELASFAGVWEYRINLLWDSAPFEETIADRDDRLRELRQRQQQSGAGKKFLLEKQSDQRLQELKRERRTELADQLKEAITPVVNDLTEQDTNTPLQDEHSSIEKEQIVRFAVLADEDDETALGDRLDTIVEHEGVEIRFTGPWPPYTFAPDIGK TPA_BK010831.1 DAC79692.1 tpg 17547 17888 - gas-vesicle operon protein GvpK Loose gnl|BL_ORD_ID|1560|hsp_num:0 Erm(39) 33.93 3000602 macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase erythromycin; roxithromycin; lincomycin; telithromycin; clarithromycin; clindamycin; tylosin; spiramycin; azithromycin; dirithromycin; pristinamycin IA; quinupristin; virginiamycin M1; madumycin II; griseoviridin; dalfopristin; pristinamycin IB; virginiamycin S2; pristinamycin IC; vernamycin C; patricin A; patricin B; ostreogrycin B3; oleandomycin MELALDDDADDLQGGLTALVVTVVELLVEALEQEAVRRMESGSLSEDEIERLGRQLQALEDELERLKQQEDINAEVSEFREDLDHVIRDAIEQLSEHETPSGHGSPESQRDDV TPA_BK010831.1 DAC79693.1 tpg 17890 18234 - gas-vesicle-associated protein GvpJ Loose gnl|BL_ORD_ID|1625|hsp_num:0 QnrS7 30.77 3002796 fluoroquinolone antibiotic antibiotic target protection quinolone resistance protein (qnr) ciprofloxacin; levofloxacin; moxifloxacin; gatifloxacin; nalidixic acid; norfloxacin; sparfloxacin MSDPKPTRSQGDLAEMLEMLLDKGVVVNADIAVSVGDTELLGIELRAAIASFETAAEYGLEFPTGTDMERVESAANISPDQSDPASETQSETESTNPLSDDSTPTASTSAEETK TPA_BK010831.1 DAC79694.1 tpg 18227 18661 - gas-vesicle operon protein GvpI Loose gnl|BL_ORD_ID|2732|hsp_num:0 OXA-476 27.78 3003633 penam antibiotic inactivation OXA beta-lactamase; OXA-63-like beta-lactamase oxacillin MSDKQQQKHKQKARQARVKAQINRDKARRNLLRQREKLARRRTRNRKQSEPRRDDSDGDDTDGETVKNPAAHSTMPPQKSNAENAVRNSHSTVPKTPKYSDVTARERLYGQRLHQKTAGGNSEASAPSDESASGSPTEDEVNDE TPA_BK010831.1 DAC79695.1 tpg 18658 19206 - gas-vesicle operon protein GvpH Loose gnl|BL_ORD_ID|409|hsp_num:0 mtrE 26.42 3000812 macrolide antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; penicillin; azithromycin MVPDENDDASDDQSSQLSGLLDQLHTLVEVLADIEEEGGHRHESGRIDRGNARIDYDYDVSIGLGRADGSSYDEEPSSNRSRSEQRSGQQRTTEDSIHVETRGGTSGDELVVVADLPGVTDDDVDVALDTDEQALTLRVDDDVVERVVLDRPDVAITDMTLRNQVLEIRLARTSDTDGGEST TPA_BK010831.1 DAC79696.1 tpg 19206 19457 - gas-vesicle-associated protein GvpG Loose gnl|BL_ORD_ID|2324|hsp_num:0 FONA-6 26.53 3004793 penam antibiotic inactivation FONA beta-lactamase MFIIDDLFVSPFFSLLDILQTMALDEMYDTKSIRDDIKENQLLYEVGERSDEEYQQRKQALESQLEMAEQVQEQMRDRMEVKK TPA_BK010831.1 DAC79698.1 tpg 20095 20670 - PadR family transcription activator GvpE Loose gnl|BL_ORD_ID|663|hsp_num:0 LRA-8 35.9 3002487 cephalosporin; penam antibiotic inactivation subclass B3 LRA beta-lactamase MDDLLEELTADIDANAAISFAVTDLESVIESDGASDHADQPPDEGATQRYTDTPLTDDAVATMDGWLDNDQLHTISDAIVTEHIDEILLLLITVRDGACGKELLQDLRRLFGADLSPGTVYPHLNDLAVEGVLEVQKLSKRKVYRLSDPEGAFTRIDHMVDQLLLFSLVLKAVMTDCKARQSQSQGRETND TPA_BK010831.1 DAC79699.1 tpg 20673 22283 - regulatory protein GvpD Loose gnl|BL_ORD_ID|4829|hsp_num:0 HelR 30.61 3007208 rifamycin antibiotic antibiotic target protection helicase-like RNA polymerase protection protein rifampin; rifaximin; rifabutin MSSPNLAHPPTDYTGIVLFPRELSQFFMGDAGETLLINGAPGTGKTLFTIRGLDVLDRDSDVLYVSTRVDQETVHEMYFADHSSLDTTAILDLFQDPFELPLDVDVPFEKLDLDSLLEWIQEINAATTQLTIAFDSWELIYEYLAVRHDDPPDIKTVTNQLAVLAREENIRLMLVTETAAPSSLEYIVDGVVTLQVKEDDRGRTRRDLRLDKLRGVRIGNRLQPFTLADGQFQVITPVELLTIQTGTGNGTWDPLANSKAKFSTGIRDLDRILSGGYNRGSVVHLDLGPDLSRDAWSVLTLPTIRNFLSQEMGVAVVPPREGSPGLLHNDLNTVLSSQVFDTYCHVFETYAGPSDSADRYDQPDSTESFSEMATTTPPDDAPTATHETDGADDGSRSTDGVTGSDQPHPIDEDFESPIEGGQLAYEPYMAYVEQVREESEDPLLHVISMDTAQEAFETRLGDFANYVALHNDLTLLITKQGTELRTRADRVADMHFRLERSGDAIILYGENPLTPLLGIGISQSESIPKITLTEMV TPA_BK010831.1 DAC79700.1 tpg 22484 22714 + gas-vesicle major structural protein GvpA Loose gnl|BL_ORD_ID|1011|hsp_num:0 AAC(3)-VIa 69.23 3002540 aminoglycoside antibiotic antibiotic inactivation AAC(3) sisomicin; 6'-N-ethylnetilmicin; gentamicin MAQPDSSGLAEVLDRVLDKGVVVDVWARVSLVGIEILTVEARVVAASVDTFLHYAEEIAKIEQAELTAGAEAAPEA TPA_BK010831.1 DAC79701.1 tpg 22804 23952 + gas-vesicle minor protein GvpC Loose gnl|BL_ORD_ID|491|hsp_num:0 emrY 29.17 3000254 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MSVTDKRDEMSTARDKFAESQQEFESYADEFAADITAKQDDVSDLVDAITDFQAEMTNTTDAFHTYGDEFAAEVDHLRADIDAQRDVIREMQDAFEAYADIFATDIADKQDIGNLLAAIEALRTEMNSTHGAFEAYADDFAADVAALRDISDLVAAIDDFQEEFIAVQDAFDNYAGDFDAEIDQLHAAIADQHDSFDATADAFAEYRDEFYRIEVEALLEAINDFQQDIGDFRAEFETTEDAFVAFARDFYGHEITAEEGAAEAEAEPVEADADVEAEAEVSPDEAGGESAGTEEEETEPAEVETAAPEVEGSPADTADEAEDTEAEEETEEEAPEDMVQCRVCGEYYQAITEPHLQTHDMTIQEYRDEYGEDVPLRPDDKT TPA_BK010831.1 DAC79702.1 tpg 23949 24992 + gas-vesicle operon protein GvpN Loose gnl|BL_ORD_ID|4984|hsp_num:0 Clostridium perfringes cplR 27.63 3007644 lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; pleuromutilin antibiotic antibiotic target protection Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins lincomycin; clindamycin; virginiamycin M1; retapamulin; iboxamycin MTNESRKRKVRGSQIRSSRGDKKQGRSQSRDDKEIERLERQNDARGQESSTHVDEGFVPEEQSFIETESVNRVESRMERWLDVGRPVHLIGPTGCGKTSLAMHVARERDRPVVWINGDAELTTSDLVGEYAEKERISEHDQFIHNVVKSKDIIRDRWVDNPLTLAVQEGATLVYNEFSRTKPVANNVLLSVFEEGVLELPGKRGKSRYVDVHPEFRTILTSNSVEYAGVHEPQDALLDRLIGIYMDFYDLDTEIEIVRAHVDKSADTNVEDIVRVLRELRERLDITVGTRAAIMANEGATTVDTVDQAVLTDICTDVLASKVAQRSDVRGLREEIESAIDDMEVALS TPA_BK010831.1 DAC79703.1 tpg 25017 25376 + gas-vesicle operon protein GvpO Loose gnl|BL_ORD_ID|1787|hsp_num:0 MexB 25.42 3000378 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole MADPANDRSEREEGGEDDETPPASDGNPSPSANSFTLSNAQTRAREAAQDLLEHQFEGMIKAESNDEGWRTVVEVVERNAVPDTQDIIGRYEITLDGTGDVTGYELLERYRRGDMKEEL TPA_BK010831.1 DAC79704.1 tpg 25405 26169 + ParA domain protein Loose gnl|BL_ORD_ID|2562|hsp_num:0 HERA-8 36.0 3004822 penam antibiotic inactivation HERA beta-lactamase MAHRLTVANEKGGVGKTTIAINVAGALADRGHDVLFVDLDAQGNGTIGLGLDAAYTGDGISLYDILTDLDAQQQIDAVIRSHEEFDVLPSHIDMFSAESELQTAMRGRERLWMALDELHADYDYIIIDAPPSLGLLTDNALLACRNVLIPALPEEASRHALDILFGHVDTLEDGYGVDIDPIGLVANRIEVDGEADRILEWFDEQYKSLPLWRIRNRVGIKRAWANGTSVFGHSETTDMDERFQAIAAHLERTE TPA_BK010831.1 DAC79705.1 tpg 26683 29202 - receiver/sensor box histidine kinase Loose gnl|BL_ORD_ID|2785|hsp_num:0 ParS 31.6 3005067 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux; reduced permeability to antibiotic resistance-nodulation-cell division (RND) antibiotic efflux pump; Outer Membrane Porin (Opr) erythromycin; amikacin; gentamicin C; ciprofloxacin; acriflavine; tetracycline; tobramycin; meropenem; imipenem; chloramphenicol; norfloxacin; ofloxacin; gentamicin MARTRNPGRGGGGSIQVLHVDDEPDFADMAAEFLEREDDRLTVESATSASEGLDRLDEHDYDCIVSDYDMPGMDGVEFLETVRKAYPNLPFILFTGKGSEQVASEAIAAGVNDYLQKGSGSEVYELLGNRITNHVERVRAQRKQQRHLDAIETAQEGISILDEDEHFRYVNQSFADLYGYEPAEMIGEHWELIYPDEEVQAINEEVLSIVEETGYWRGETTGLRADDSTFIEAHTLSQTDEGGLICTARDITEAQEQAQELEEVTQQYRTVVEQSRAGIRIVQDGTVKFVNDRLAEMLGYPKHELLGAPAEEIITSETEDIVRRHHATRMQGEPAPDRYEVEVDTEAGDRLCVELSVARIQYAGKPASLSLIRDITERKEGEQALERYAALFDNAPDATALVEYRDETPIIRDANPAFEALFAGGDGDIVGQDIDGVVASSDQVAEARTISQQVQEGEPIQKELTRETADGLRTFDFRSVPVEDRETGEIESAFVIYPDITERKAHRRELERYETLVEATADPMYMLDEEGRFTYVDDAMVETTGYSEETLLGEHVSKVMEEDHVERGEQLIESLLSSGEKRGTFEMVIETAGGERFSTENHISLLDGDGEFHGTAGVLRDITDRLERERQLKRERDRLDEFASVVSHDLRNPLNVAEGRLELAMENCESEHHDSVAQSLDRMESLIDDVLSLARAGEAVGETEPVELADLVEACWQTVETASAGLVVETETTIQADPSRLQQLFENLLRNAVEHGGEDVTITIGDLPDGFYVEDDGQGIPEDERGNVLDAGYSTAADGTGLGLSIVREVAEAHGWEIEVTESSDGGARFEIIGVQMEG TPA_BK010831.1 DAC79706.1 tpg 29637 29789 + small CPxCG-related zinc finger protein Loose gnl|BL_ORD_ID|4692|hsp_num:0 Staphylococcus aureus mupB conferring resistance to mupirocin 60.0 3000510 mupirocin-like antibiotic antibiotic target alteration antibiotic-resistant isoleucyl-tRNA synthetase (ileS) mupirocin MNGDASILGRCPDCGERISEAWLLVEYEKDDGETGIWAECSTCEGVVSPK TPA_BK010831.1 DAC79707.1 tpg 30044 30346 + homolog to TATA-binding transcription initiationfactor Loose gnl|BL_ORD_ID|1813|hsp_num:0 OXA-47 29.27 3001781 cephalosporin; penam antibiotic inactivation OXA beta-lactamase; OXA-1-like beta-lactamase oxacillin MEDPKDTITIENVVASTAIEQELDLSRVAMDLEGADYDPEQFPGLVYRLDEPSVVALLFGSGKLVITGGKHPVDAEHAVDTIDSRLEDLGLLDGYGDRAK TPA_BK010831.1 DAC79708.1 tpg 30622 31896 - ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|2194|hsp_num:0 catII from Escherichia coli K-12 39.53 3004656 phenicol antibiotic antibiotic inactivation chloramphenicol acetyltransferase (CAT) chloramphenicol MRRLTTLFPSEFLEDHAEELGVVERDRKLQIPAFVWAFVFGFAAGESRTLAGFRRCYNSTADETISPGGFYQRLTPTLAEYLRDLVEHGLDEVAVPNAVDADIDRFRDVMIADGTVLRLHEFLSDQFEARHEEQAGAKLHLLHNATEQTIEQLDTANEKTHDSTLFKTGPWLENRLMLFDLAYFKYRRFALIDENDGYFVSRLKQNANPLITGELREWRGRAIPLEGKQLRAVLDDLDRKYIDVEVEVEFKRGPYNGTQSLDTKRFRVVGVRDEDADDYHLYMTNLARKEFFPADLAEIYRCRWEVELLFRELKTQYELDEFDTSDEHVVRILLYAALLSLLVSRDLLDLVTEQADDELVFPTERWAATFRSHAQLILHELGEFLGYSPPPLLDRLIEDAQKIHKQRPILQETLATTTQPRCEA TPA_BK010831.1 DAC79710.1 tpg 34534 35361 + ISH9-type transposase ISH9 Loose gnl|BL_ORD_ID|1560|hsp_num:0 Erm(39) 38.46 3000602 macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase erythromycin; roxithromycin; lincomycin; telithromycin; clarithromycin; clindamycin; tylosin; spiramycin; azithromycin; dirithromycin; pristinamycin IA; quinupristin; virginiamycin M1; madumycin II; griseoviridin; dalfopristin; pristinamycin IB; virginiamycin S2; pristinamycin IC; vernamycin C; patricin A; patricin B; ostreogrycin B3; oleandomycin MSKISRFTKKAVQLAKNAVGGRGEVAAPEGGGGFADYAIVSLHCLRVYLEKSYRETLDLLSEMPHILAEIGLNEADLPDHSTLVKAFDRLKTALWRVLLRLSAQLHDPSGHAAIDATFFDRETASKHYCRRTNYRVQTLKTTALVDTETQAILDVHCSTGKPHDTQLGWQVARRNAGDLASLAADKGYDWMELRKKLREDGVRPLIKHRIFRPIDHAHNARVDGPRYRQRAMCETVFSTIKRTLGDAVRARAWFREFREIVLKCVVHNIKRAVTP TPA_BK010831.1 DAC79711.1 tpg 36819 37811 + ISH11-type transposase Loose gnl|BL_ORD_ID|4561|hsp_num:0 RAHN-2 35.29 3006980 cephalosporin antibiotic inactivation RAHN beta-lactamase MSPATLQDDPSVDSFFNVVETETLALFEHLSFEFLEEFDVFAPAETGRTRDHEPPELMRGFLHCYYKDIYGIRPVERELRNTVVWLSCGFDRPPSRDAVDRFLTDLEHVVNKVFDHLVEQAALRGLLDLTYCIDSTDVRAMPADQDASKCYDPTDDEYYHGYGCTIVSTGQKIPIAAEFTESKQAPEETAMRVTRDALAVAKPIWMVGDSAYDTLDWHDHLLAAGVVPVAPYNARNTDDPKDIEYRVEDRIEQHSEDVQLKQSTLDETYNRRTGVERTNESVKDCGLGRTHARGRVHARAQVFLALCLRLVVAITNYERGDNPGSPIITV TPA_BK010831.1 DAC79712.1 tpg 38251 38520 - uncharacterized protein Loose gnl|BL_ORD_ID|2347|hsp_num:0 basS 41.46 3003583 peptide antibiotic antibiotic target alteration; antibiotic efflux pmr phosphoethanolamine transferase polymyxin B MSQNTVNTTVSIKPADALFLSWATGTNASGLFREAVAEQMMYRDIDRDELSTLTEEALTETSRDLDDLLEQTSSIEDLNTLLETDPASD TPA_BK010831.1 DAC79713.1 tpg 38679 38900 - uncharacterized protein Loose gnl|BL_ORD_ID|2305|hsp_num:0 tetA(46) 33.33 3004032 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MNYPSLRGYGAVLVVGVAVICMGVIALGFIMPTRLFESTVGLVAFFAAALLMVICAVVANFYDLREVLHEEFG TPA_BK010831.1 DAC79714.1 tpg 39204 39371 - uncharacterized protein Loose gnl|BL_ORD_ID|4666|hsp_num:0 vanS gene in vanB cluster 45.83 3002932 glycopeptide antibiotic antibiotic target alteration vanS; glycopeptide resistance gene cluster vancomycin MSDLIVKAAVKDELSEHNVSADFYAALNEEVAELLDDAADRAEANERKTVQPRDL TPA_BK010831.1 DAC79715.1 tpg 39504 39785 + PadR family transcription regulator Loose gnl|BL_ORD_ID|2039|hsp_num:0 mphG 28.57 3003742 macrolide antibiotic antibiotic inactivation macrolide phosphotransferase (MPH) erythromycin; clarithromycin; azithromycin MHDLTGFQRDILYVIADFEEPHGLALKDELEVYYEQEINHGRLYPNLDDLVDKGLVEKGELDERTNSYTLTQRGHREITARRDWEQQYVDLSE TPA_BK010831.1 DAC79717.1 tpg 40577 40747 - small CPxCG-related zinc finger protein Loose gnl|BL_ORD_ID|3290|hsp_num:0 AXC-3 40.0 3006899 carbapenem antibiotic inactivation AXC beta-lactamase MGENCDKCGTELGSSQERHQRYRIEHPSDSVETLEGRLCSDCFWELKEWLETEEVT TPA_BK010831.1 DAC79718.1 tpg 40819 41202 - uncharacterized protein Loose gnl|BL_ORD_ID|4680|hsp_num:0 vanS gene in vanF cluster 30.43 3002936 glycopeptide antibiotic antibiotic target alteration vanS; glycopeptide resistance gene cluster vancomycin MFTVDETYDGFEFTLRNQTTASLTITRTKAWEIERHTSDGWEQVATEVGVAEGKTRTLDCGEAHSWHHALFEHPTLPSRKTTYLFENLSEGLYKFSVTGNLETGVEITRETQFEVQRQLPPQTKTDE TPA_BK010831.1 DAC79720.1 tpg 42257 43705 + cytochrome bd ubiquinol oxidase subunit I Loose gnl|BL_ORD_ID|3409|hsp_num:0 CRP-1 25.97 3006868 carbapenem antibiotic inactivation CRP beta-lactamase MVPATLLSTVDLGWMALLSPEIASRMQFGWTISVHIIFASLSIGLAPFIIYFTWKDVRTNEQRYARLRSFWVKVFAVGFVMGTVTGIPMSFQFGTNFPQFATIAGELIGGPLAFEAKMAFFLEAVFLGVLLYGRERVADRTYVLSSVLVGVGAWLSGFWILVVNAWMQTPRGYEMVTRNGMEVAKLTDPVAAFLTPRMPWMYVHMMNASVISVALLVAGVSAYLVWKKPDADAWNSALKLAVVLLLVSAPFQAVHGDAYGRHVEDTQPQKFAAMEAHYETGSADLHLLAFPKSLDALTDPRTENLFTVSLPGIGSFLASGGDFDAEVIGLNEYEENPPVALVFWSFRFMVGLGFLFIGLALWGGYLTYRGRLTESTRYLKSMIAASPFGYAALLTGWYVTEIGRQPWVIQGELKTSEAVSSTLTGTEATLTLVGFVVLYIALILTALYVLKWLIRGELRSLGVQESSAGRWRGPLPWVTSDD TPA_BK010831.1 DAC79721.1 tpg 43698 44693 + cytochrome bd ubiquinol oxidase subunit II Loose gnl|BL_ORD_ID|1197|hsp_num:0 mef(B) 44.19 3003107 macrolide antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump erythromycin; azithromycin MTDPLIPVDTYLVDSLPEVWFGAVVFALGMYIVLDGFDFGIGMLYATRTDEHERETFLAAFGPVWDANEVWIVAFGTMLLAAFPRVYSRLLADNYLLALGFVVALVFRGLGPELREQREDERWKRYTDYAFVGGSVFAPLLLGMLAGRWLFAGATLPVVLTGVGLVAVSIVTGAAFLAAKTDSGLASELRSYGVGATVAYLGGVVVLLGTVVATDAGGAASAVLSLPVAAVVALSIVAGLGGSVLARRGRYRAWLASALALPTLLTLLVAVLLYPTVYPPTGLLVREAVVSPLALNLVTVLGFPVLLLVLWYFKFLYGVFSGPIEGEGYGG TPA_BK010831.1 DAC79722.1 tpg 44812 45384 - DsrE domain protein Loose gnl|BL_ORD_ID|4843|hsp_num:0 MCR-4.6 38.89 3007231 peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase colistin A; colistin B MSTDTPDASVDDAPSRAELAARVNELEDALAEATSEDDAKKMSIISTKGTLDMAYPPLILASTAAAFGYEVTVFHTFWGLEILHEERSKNLKLSSVGNPNMPVPNAVAALPGMDRVTTKMMEKKIDDNDTATIEELIETSLDMGVEFQACQMTIDLMDYDEDDFYDGVTTGVGAATALQDMAEADIQLLV TPA_BK010831.1 DAC79723.1 tpg 45387 45632 - UPF0033 family protein Loose gnl|BL_ORD_ID|741|hsp_num:0 mecC 41.38 3001209 penam antibiotic target replacement methicillin resistant PBP2 methicillin MSADYDITETLDVKGASCPMPVVKTKSAIDDLAEGEILEVLATDSGSMSDIDGWASGTAGVELVDQEEGDDVYKHYVRKTK TPA_BK010831.1 DAC79724.1 tpg 45882 47075 + rhodanese domain protein / beta-lactamase domainprotein Loose gnl|BL_ORD_ID|3333|hsp_num:0 CAR-1 35.11 3006903 carbapenem antibiotic inactivation CAR beta-lactamase MNADDFPTPDADVESVDPESLKDRIDAGEDVTLLDARMTSDYEEWHIDGENVTSINVPYFEFLEDDIDEDVLDQIPDDREVTVLCAKGGASEFVAGTLAERDYDVDHLEDGMNGWARIYDAVEVEGYDGAGTLLQYQRPSSGCLGYLLYDDGEAAIIDPLRAFTDRYLDDADNLGVDLQYALDTHVHADHISGVRNLAEEDIEGVIPEAAVDRGITYADDMTTAADGDTFDVGDATIEAVYTPGHTTGMTSYLVDDSLLATGDGLFIESVARPDLEEGDDGAPDAARMLYESLQERVLTLPDDTLVGGAHFSDAADPAADGTYTAPIGELVDEMDALTMDEQAFVDLVLSDMPPRPANYEDIIATNLGQNAVDDEEAFTLELGPNNCAASQDSLAGD TPA_BK010831.1 DAC79726.1 tpg 47575 48033 + DUF4341/DUF395 family protein Loose gnl|BL_ORD_ID|467|hsp_num:0 tetA(P) 21.62 3000180 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MSDRHPAFMPLILVGGLIFGFGLAYSQMARPEVVLNFLQFEDFGLVFVMFGGAAVTGVTFFVAPRLLGRAPLTGDSFQRRLKSFDRNVLIGGAIFGVGWGLSGICPGAAYASLGIGNITILWALAGMFLGAYTQGFWRSHSQSRDASSAGAD TPA_BK010831.1 DAC79727.1 tpg 48044 49219 + transport protein (probable substratephosphate/sulfate) Loose gnl|BL_ORD_ID|2428|hsp_num:0 rpoB2 37.78 3000501 rifamycin antibiotic antibiotic target alteration; antibiotic target replacement rifamycin-resistant beta-subunit of RNA polymerase (rpoB) rifampin; rifaximin; rifabutin; rifapentine MDPALIALFAGAALASLFMAWVIGAGSSGATPYAPAVGANAISTMRAALLVGIFGFVGAVTQGGNVSEAIGSGLVGGISLPIAGVILVLVLGAGLMAIGITTGYPIATAFTVTGAVIGVGLALGGSPVWPKYQQIAAVWVLTPFVGGGIAFTIASLLPRPGVPERYSIPVLAGLVGAVLVNIQFSFLGAGSAAGTVRGVGQRVLAVDGLTSAVGITGFAALVVATVVWWDVSRDERGGLRRVLLALGSLVAFSAGGSQVGLAVGPLLPLLDEVGMVSTFAVLVGGGLGMLVGSWTGAPRMIKSLAQDYSSLGPRRSISALVPSFLIAQLAVLLGVPVSFNEIVVSAIIGSGAAVGGREAVDARKIGVTIGAWIGSFALSFALAYAAGALLL TPA_BK010831.1 DAC79728.1 tpg 49236 50012 - HTH-10 family transcription regulator Loose gnl|BL_ORD_ID|2576|hsp_num:0 ADC-164 40.54 3006336 cephalosporin antibiotic inactivation ADC beta-lactamases pending classification for carbapenemase activity MTGTANYVEFEPTRMGLYEASIRVKHECPYRRISERYPDLTIREWPLSDCQVLEITTETTPTDELLDEINEIGTVLYESADDNGYHVVTQSCLCSLEDSVIDRFEEHNCLYQSPTIYRQGWEHYTVVAFDSEDVRELLDSLRSDREIELLSKTSISETQIPHSMLAPANQLFEDITDRQLAALQLALESGYYEQPRKTSLRDLAERTAVARSTYEEHLRKAENKLLTNAGQFLRLVTATSTTNPLGVESGRRTEQTAD TPA_BK010831.1 DAC79729.1 tpg 50060 51169 + rhodanese domain protein / beta-lactamase domainprotein Loose gnl|BL_ORD_ID|1587|hsp_num:0 IND-4 25.81 3002260 carbapenem antibiotic inactivation IND beta-lactamase MQELSPAELGEQVQDDDGPLVLDIRHEEDFQEWHIPGSRNVDVYDELTDDPEQAIEPLDDLPSDEQIVTVCAAGVVSQTATAVLRELGYDAVTLTDGMNGWSRVHRHAELPVDVDGTLVQVARPGKGCLSHVLVSDGEAAVFDPSHYLNEYDTVLDEYDAELVGVFDTHAHADHVSGAADLADRHDVPYYLHQKDALAVDATPLEDGQTVTVGRLDIEVIHTPGHSEGSVSFDVEGAALLTGDTLFHDSVGRVELGVEAGIEDADVEGNAATLYESLQRLLDRPDDALVLPAHDPGSPEPPVAATLAEVRERNDDLGRDREAFVEELASDIPDHPPNFERVKRTNVGQESVPEEELAELELGPNNCAAE TPA_BK010831.1 DAC79730.1 tpg 51173 52438 + major facilitator superfamily transport protein Loose gnl|BL_ORD_ID|1484|hsp_num:0 tet(41) 24.77 3000569 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MSTTTELRQGIREHLGQFSLHVLLVFATGLTIGSERTVVPVLGEDVLGVESFLVIGSFVVSFGIVKSILNLYAGKWGEAYGRKPVLIAGWATALPLPIILIFAPSWGWITVGNVLLGINQALTWSMAINAKIDLAGPDQRGLAVGIDEAFGYTGVAVGAWITGVIAGQWSLRPEPFYFLAVVVVLAFLISIFLIKETVQYAQAEGNDDHHDANLPFNEVLKRATYGDRTLFAAAQAGHIENFVDTLFWIAVPLYLTSQGLGIAAVGVVVGVHSAMYFLQIATGGLADRIGRRPPVVAGMFLAGAGVLGMVLVDGYLPWAVLAGVSGLGMALLYPNLMTVPSDAAHPTWRSAGMGVYRMWRDSGYAVGAVLIGLSMEFVNAAAAFYLTAGLMFASGAVVYVWMEETHPDFGTHEPPAPAPSD TPA_BK010831.1 DAC79733.1 tpg 53918 54322 + TrmB family transcription regulator Loose gnl|BL_ORD_ID|810|hsp_num:0 APH(6)-Ib 32.26 3002658 aminoglycoside antibiotic antibiotic inactivation APH(6) streptomycin MPDSMSEQLRQDMECEGLLECFHGLKELDKECFQALVEAEEPMTVDELAEAVDRERSTAYRAVQRLLQTGFIEKEQVNYEQGGYYHVYSPSDPSQITDDMQRMLNDWYAKMGQLIQEFETKYEQPDSVPQSAES TPA_BK010831.1 DAC79734.1 tpg 54498 54857 + thioredoxin Loose gnl|BL_ORD_ID|2297|hsp_num:0 Pseudomonas aeruginosa CpxR 34.55 3004054 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump neomycin; erythromycin; amikacin; ciprofloxacin; kanamycin A; tetracycline; tobramycin; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; gentamicin MATDTAATTGTASPDEPLYVNGQTELDDVTSDNDVVLADFYADWCGPCQMLEPVVETLAEQTDAAVAKIDVDENQALASAYGVRGVPTLVLFADGEQVEEVVGLQDEDALKDLIESYTE TPA_BK010831.1 DAC79735.1 tpg 56131 57249 - XerC/D-like integrase Loose gnl|BL_ORD_ID|1374|hsp_num:0 ACT-4 40.62 3001829 carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation ACT beta-lactamase MSNNDATPGVRGLETLLDDRMVSLESPQTQQITRVAVNNLFQFLTENNDVDSVADVDEQDARDWVIHLVKEDDLAANSIRTYFALARATFGWWQRSGEIGQNPLATTTAEEVLPSKSNDVEQQFWTADARERLLNYVDERAHAALENDSSDAARAFRDRSLVYILADTGVRGAEICSVSRDNRRNGLRWTDVDLEAGVMTVLGKSGDQESVSLPGVTSEKLARYRRLVDAPAEWPVIPTGDATSKYRAVRKQLREREYGDEAIEGVLEDCEIDEVLREYEVAPPALTTEGARTLLKRLCGEADVDIDGDYLKPHGGRRGLGDELYGEVAAESAQEVLRHKSIETTHASYRERRAEDLSADIEKVRYSNTDEE TPA_BK010831.1 DAC79737.1 tpg 57972 58352 + uncharacterized protein Loose gnl|BL_ORD_ID|131|hsp_num:0 cpxA 63.64 3000830 aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump neomycin; amikacin; kanamycin A; tobramycin; novobiocin; gentamicin MVSGWQVIRVACILSVSVGVGLLAISISLGLTAGTAPPVLVGFGGSVCTAYLLLRKHPNIETGPLWRFSGLVFVLFILGNAVSTEGIYAPQSEQSPLAIGGVWALSLLICYTVIFKVEWTNRSPSQ TPA_BK010831.1 DAC79738.1 tpg 58617 59891 + ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|2034|hsp_num:0 vanJ 30.0 3002914 glycopeptide antibiotic antibiotic target alteration vanJ membrane protein teicoplanin MRRLTTLFPSEFLEEHAEELGVVERDRKLQIPVFVWAFVFGFAAGERRTLAGFRRSYNSTADEPISPGGFYQRLTPTLAEYFRDLVEHGLDEVAVPDTVDVDIDRFSDVMIADGTVLRLHEFLADQFEARHEEQAGAKLHLLHNATEQTIERIDVTDEKAHDSTLFKTGSWLENRLVLFDLAYFKYRRFARIDENGGSFVSRLKQNANPVITDELREWRGRAIPLEGKQLRDVLDDLDRTYIDVEVEVEFKRGPYNGTRSLDTKRFRVVGVRDEDADDYHLYVTNLSREEFFPADLAQIYRCRWEVELLFRELKTQYDLDEFDTSNEHVVKILLYAALLSLLVSRDLLDLVTEQADDELVFPPERWAATFRSHAQLILHELGEHLGYSPPPLLERLIEDAQKIHKQRPILQETLATATQPRCES TPA_BK010831.1 DAC79740.1 tpg 60258 61340 - isopentenyl-diphosphate delta-isomerase%2C typeII Loose gnl|BL_ORD_ID|3890|hsp_num:0 OXA-640 25.37 3005861 penam antibiotic inactivation OXA beta-lactamase; OXA-184-like beta-lactamase oxacillin MTAQDSTQTEDRKDDHLQIVQERDVETTGTGFDDVHLVHNALPELDYDAIDPSIDFLGHDLSAPIFIESMTGGHHNTTEINRALARAASETGIAMGLGSQRAGLELDDERVLESYTVVRDAAPDAFIYGNLGAAQLREYDIEMVEQAVEMIDADALAVHLNFLQEATQPEGDVDGRNCVAAIERVSEALSVPIIVKETGNGISGETARELTAAGVDALDVAGKGGTTWSGIEAYRAAAANAPRQKQIGTLFREWGIPTAASTIECVAEHDCVIASGGVRTGLDVAKAIALGARAGGLAKPFLKPATDGPDAVIERVGDLIAELRTAMFVTGSGSIDELQQVEYVLHGKTREYVEQRTSSE TPA_BK010831.1 DAC79741.1 tpg 61626 62279 + TrmB family transcription regulator Loose gnl|BL_ORD_ID|4986|hsp_num:0 PSZ-1 25.0 3007648 cephalosporin; cephamycin; penam antibiotic inactivation PSZ beta-lactamase cefoxitin; cefazolin; amoxicillin; benzylpenicillin; ampicillin; cefalotin MVSSFVTLHKMSYDTEHVRNAGDTPGTITGIPTFAELLENPSLADLYTSIRQAETATGPELVETTTVSKKTVYDYLHKLEQAGLISKVGDETGTAVYTAQEFELTLTVRETEVSITPKIIEVIAQKNEYPAIERVLEDYGIVTFALAYDLVNAHSEGEVTIRQIASLTDLSPGTTYDLVEALYSVLDLGDDDSTPTTYTPDEFDAEGGDLLEEYADK TPA_BK010831.1 DAC79742.1 tpg 62291 62848 + uncharacterized protein Loose gnl|BL_ORD_ID|1876|hsp_num:0 TEM-60 25.27 3000929 monobactam; cephalosporin; penam; penem antibiotic inactivation TEM beta-lactamase ceftazidime; ampicillin MYTANIADTVMFRNLGKHPSPHLQSLKSAVEEAGTEVWVPAAVYHELADTGSADSPTNPYLDTAIEEGWLRVATPLPGDRTAGFESSAGPVEKARFVADEFLNQQSKYPETNNWQDAAVVALAVRLFDANARIRVITHTADENLAKACARIPPEFGYYDIKSRYYNPPQTAKVEFPTVGQLTWSE TPA_BK010831.1 DAC79743.1 tpg 63243 64667 + ISH10-type transposase ISH10 Loose gnl|BL_ORD_ID|2673|hsp_num:0 MCR-7.1 30.3 3004517 peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase colistin A; colistin B MVIVDRDDLSKDELLSRFLQMEERIDELEEKLEQKDERIEELETRLRKYENPHTPPSKRRSGTDESPTSQDDEDDDVRTDGGTPGRKDGHDPEWRSTTDPDEEIEVTCDCCPECGDHFDESVGVSPRLVEEIPDPQPPEITRYNRHYYQCDSCGTETVAAHPDCPDEGQFGVNVIAQSALSRYDHRLPYRKIADRFEQLHELELSGASAWHATERAARAGRCEYEQIRREIQDADVVHIDETGIKRDGEQAWIWTFKTAQHTLYAVRESRGSDVPAEVLGEDFAGTVICDGWTAYPAFSSNLQRCWAHILREAEDAAEKQAEGEPIYHALRQVYVALQARLESDPSPRERADLQRVARRELESLIERSVPDGPVATLLGKIEGGLDHWLTFVGEPAVSPTNNAAENALREPVVLRKIIGTLRNDRGMFVHETVLSLLATWRQQGRNPYEELRRVVSSNEMLSRAHAVPAVETSG TPA_BK010831.1 DAC79744.1 tpg 64901 65320 - uncharacterized protein Loose gnl|BL_ORD_ID|2563|hsp_num:0 OXA-156 31.34 3001461 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-62-like beta-lactamase oxacillin MADDGDPFADLSQTLDDDADDQDETKSEQEPREPPASDTTTEHVDEPDEGDVEELDPMTDTAFSYEAANQRPFYAREETIENFDSWLNYELERELSTRGYQNIVVREMTDALLRTVVEEDLVDEVAERFEQERKNAISK TPA_BK010831.1 DAC79745.1 tpg 65313 66251 - ParA domain protein Loose gnl|BL_ORD_ID|2140|hsp_num:0 ANT(4')-Ib 35.14 3003905 aminoglycoside antibiotic antibiotic inactivation ANT(4') dibekacin; amikacin; tobramycin; isepamicin MAGTNSGNSIDSTNSPNSPYDSVDTAGNSRAVSVCMLKGGVGKSTIAVNLARQLATHDHDVLLIDLDPNGHASVGLGFDDHYHNTDEGIGEVFFDEADPTSVVYDTEYEFDILPSSEDLEQVEREIVVGDVFQPSALLKREVVEPLLGDEYDFIVTDSPAYRSRLTDNALVATSNLVLPLAPGNEAMSGLERTIERQIAPLRKHMDVDVLALVPNMLDGRIDQQTQDRQLLERLNSHNSLQDRIPNFARITDWEAVGSGDISPTPGIRDRTSITKAYGERKPLLDYDANCDQLKNFDELAHIVEAGEVVRHG TPA_BK010831.1 DAC79746.1 tpg 66513 67316 - DUF1814 family protein Loose gnl|BL_ORD_ID|3156|hsp_num:0 ADC-129 39.29 3006304 cephalosporin antibiotic inactivation ADC beta-lactamases pending classification for carbapenemase activity MISQNRLRVLARELGVRQGYAEKNYVNSWILWGIFTSDFGENLMFKGGTALSKLYFPQSWRFSEDLDFGVEGQYNGSEDDLRDVLDTVTERSGIEFTISEHHESRQQHYPTHYVDMSIQYRAVLDHPNTTSLDVMVDEYVAFDSVHHTHSYEDIPEFELQAYSVEEIFAEKLRAIFQRGAARDYYDLYQLLETESVEIEFDVVLPAFEAKCDHDDLDVDLTTGLPGDQREDIQRQWETSLPDLTGDPPLFDTVWKRLDEAVIDKGTE TPA_BK010831.1 DAC79747.1 tpg 67322 68152 - DUF4095 family protein Loose gnl|BL_ORD_ID|2198|hsp_num:0 catB11 29.51 3004660 phenicol antibiotic antibiotic inactivation chloramphenicol acetyltransferase (CAT) chloramphenicol MSSTQETQTIRQGLSTRESRLLSHLAAEGHQIISIDDVEATLEVAPNTAREIASRLTEKGWLDRLLPGRYLIIPLAAGEEAVYTTHEYLIASHVAEPMYIGYYSALSHHGLTEQVPRTVYVVTPTRAQSREIHGVPYRVATVTERKFFGYEPTSIEGTVVNVADLAKTLVDCADHPEYCGGIRELATAMVAADDQACSWATVGEYLQRLDNGAATKRIVYLADQLSIDLPTRETLVESFTSGYSLLDPTQSEQGSYDSEYRLRINVDPGTLGPTES TPA_BK010831.1 DAC79748.1 tpg 68245 68682 - TRAM domain protein Loose gnl|BL_ORD_ID|4979|hsp_num:0 FRI-11 30.77 3007632 carbapenem; penam antibiotic inactivation FRI beta-lactamase ertapenem; meropenem; imipenem MVEVPESLQSLFSATVEKRGETYTLEVPQTEVDHGAISPGETYRIGVLTQRQSSTKTADERTAQEQPAPSERNSGPPTPPVTEGEVRDVTIETVGDQGDGIAKVERGYVVIIPGAQPGDEPTIEIDQVQENVAFASVVDTGPQSL TPA_BK010831.1 DAC79749.1 tpg 68917 69945 + Orc1-type DNA replication protein Loose gnl|BL_ORD_ID|27|hsp_num:0 msrE 47.37 3003109 macrolide antibiotic; streptogramin antibiotic antibiotic target protection msr-type ABC-F protein erythromycin MIRDARVLRAGFVPREVEHRDAEVNHLSSVLEPITNGEPADTAIVTGPSGTGKTCISQFVTERLREEVLNVEATYVNCWRNYTRFRTLYQILDDFGETIDIHRQSTPHDELIDRLQQYDGPRTVIILDEVDQLEDPGIIYDLHSLPHFAVICIANKEEDLFSRVDDRLVSRLRSSEHVRMDKYHDEQLHDILAARVKGGLDQDVITTNQLDRIADAAAGDARLAIGILRTAASKADRESRERITDDILLNAAEDARAQIKQKNLDSLIPHQRLVYDVVREHGPLGPSEIYDHYKRKVDDPRTKRTIRTYLSKMTQYNVLEAEGTSRDREYSLVDSTAPSVTQ TPA_BK010831.1 DAC79750.1 tpg 70849 71052 + insertion element protein (ISH2) Loose gnl|BL_ORD_ID|2305|hsp_num:0 tetA(46) 28.21 3004032 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MARTKMGVSIRTELVDELDSLVDECSDLGASRSEIVEAILTAYFQNDEDQIKQTRELIIRNRKRSNS TPA_BK010831.1 DAC79751.1 tpg 72330 73019 - UPF0361 family protein Loose gnl|BL_ORD_ID|2224|hsp_num:0 LlmA 23S ribosomal RNA methyltransferase 21.11 3003982 lincosamide antibiotic antibiotic target alteration Llm 23S ribosomal RNA methyltransferase clindamycin MCGRNALFVTQEDLEKHFGAEVVTDGGYAPRYNIAPGEQLDVITNRAAAEIDQYHWGLLPSWADDPGEGIINARSETAAEKRSFRDAWDSRPCLVLSSGFYEWQKRDSGPKQPYRIYREDAPAFAMAGLWEVWEGEESAIPCVTILTTEPNDLMQPIHDRMPVVLPDGDEETWLTASPDEREELCQPYPEEDLTAYEVSTRVNNSGNDDATVIEPLDHEQSGLDEFSSR TPA_BK010831.1 DAC79752.1 tpg 73259 74656 - DUF262/DUF1524 domain protein Loose gnl|BL_ORD_ID|1608|hsp_num:0 emrA 31.34 3000027 fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump nalidixic acid MVNANIWSRDFNLRSRIDEDIFEHLDQIGFGEIDRGTVTQTLALNIDGTCSTDAQKNLDPDDVRENWEDTKEAMISAIGYLRKQHGVKRSEFIPYEGMIPVLAYYMYETDRRNVDPDHQEQIDRWFWRVALSGRYSSSAQTRMTEDSKLVDRIIAGEDVEINFTPQISTERLKTTNIKRSTSGLRNAFLCLLARNRPLHFEDGSEIDLTENEYADFRLNKHHIFPNAYLRGLDYSKKERKSIMDITFIPAELNRRLSDTSAKEYFGRLANDVNEFERIMDSHLIPHDEDSGIWDNDYDTFQEQRAELVYSEFMELIGEYSALESDLRNDPQSAVKETEVLVRDFIDRELALASDGGTFWGEVPNDVNSNVQRRISEEQDSNPEFTVDSDRDKLDFCNVMDYAKIINARWDVFGDYLPSKSAVQTRFEDFAEFRNALAHHREIDRFTEMDGQVAIEWINSCITEEY TPA_BK010831.1 DAC79753.1 tpg 74812 75015 - insertion element protein (ISH2) Loose gnl|BL_ORD_ID|2305|hsp_num:0 tetA(46) 28.21 3004032 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MARTKMGVSIRTELVDELDSLVDECSDLGASRSEIVEAILTAYFQNDEDQIKQTRELIIRNRKRSNS TPA_BK010831.1 DAC79756.1 tpg 76754 78514 - uncharacterized protein Loose gnl|BL_ORD_ID|444|hsp_num:0 mphF 25.88 3003071 macrolide antibiotic antibiotic inactivation macrolide phosphotransferase (MPH) erythromycin; roxithromycin; clarithromycin; tylosin; azithromycin MHSPRPMAAALALFLVSSSAVVVVAGGMATVTPSDSGSVVPNDGPDYGVNNSTFQRLWSEDADNGNLSADDFDDANVSSRAEFAHRLARSTDIPFDQPPQAAGDWNNGDFGDYSPGDRDSSIHPESASLEDGVYIKDAYVSIFATQPSTILHQGNETTQYVAPDGQVRALSDYRVAVPQGDQNGSQRERWSIDQTSIESVELSADGRTIDTGNGHQATLQYTGLSGSPQLTVEANITVTLRHVTLDCPDWNSSISGCDGDWTRDVETLEASKTVSTSQKVVVNRLSGISGNRVQFETHKNRVGAVIHPSTEWSTITVDGDVRARSNWWFYTAGRSGWQTMVTTTATNTSRAESSVRPVQVHAFPSQQAPYVPTEPTDDGKRPLAIEETWGTELTGPSLPVNIDLESADPYVNADSIAVSSTTLDESAFRKVTVQGIVRGQSRTVSLSEQQTVRETNLDLTVTEANATHAVVRAMVTENASDDAVTTGRVTIRNQTATLNSSGMAVVTISKPSLLVHGQYQSAAWWRTDQPYAASEDITKTPANFPDFQTLIQLAVVTILWFIPVAVLVFGFDYMSDGALLGISNRT TPA_BK010831.1 DAC79758.1 tpg 79070 79339 - uncharacterized protein Loose gnl|BL_ORD_ID|649|hsp_num:0 cmlv 51.52 3002700 phenicol antibiotic antibiotic inactivation chloramphenicol phosphotransferase chloramphenicol MSRNTVNTTVSIMPADALFLSWATGINASGLFREALAEQMAYRDIDRDELSNLVDDALTDSDRDLDDLLEQTSSIEDMNALLEADSSTD TPA_BK010831.1 DAC79759.1 tpg 79817 81091 + ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|3754|hsp_num:0 OXA-491 43.75 3005725 penam antibiotic inactivation OXA beta-lactamase oxacillin MRRLTTLFPSEFLEEHAEELGVVERNRTLQIPVLVWALVFGFAAGESRTLAGFRRSYNATADEPISPGGFYQRLTPSLATYLRDLVERGLDEVAVPNAVDADIDRFRDVMIADGTVLRLHEFLSEVYEGRHEEQAGARLHLLHNATEQMIERIDVTDETAHDSTLFKTGSWLHGRLILLDLAYFKYRRFALIDENDGFFVSRLKQNANPVITAELREWRGRAIPLEGKQIQDVVDDLSRQYIDVEVEAEFKRGQYEGTRSLDTKRFRVVGVRNEDADDYHLYITNLPRDEFLPSDLATLYRCRWEVETLFRELKTQYELDEFDTRNPAVVEILLYAALLSLLVSRELLDLVTEQADDEIVFPPERWAATFRSHAQLILHELGEYLGYSPPPLLERLIDDAQKIHQQRPILQETLATATQPRCEG TPA_BK010831.1 DAC79760.1 tpg 81426 81614 - spurious ORF Loose gnl|BL_ORD_ID|4566|hsp_num:0 SFC-1 33.33 3006985 carbapenem antibiotic inactivation SFC beta-lactamase MNDSTSYSVHLVEDCILPPSVVLMNLEDLYSPVGNRIGLAYREMMTEISVDEETTWISVSST TPA_BK010831.1 DAC79761.1 tpg 82028 83194 + ISH3-type transposase ISH3 Loose gnl|BL_ORD_ID|3042|hsp_num:0 OXA-653 39.53 3005342 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-24-like beta-lactamase oxacillin MSTTQQADGEIHEDQLLNFLVNALDEEVALTLAENAEIDAEDIYEVLVGACADGTSVSTLCEKSEDAPHENSVLYHLRTKFDLETLEQVGNALLQKDVLDVLPQQVEVVSDLHLRPYYGDEDGTDGLYHSQAKRGTTAFHAYATLYARVKNKRYTLAVRRLEDGDTASSVLAEFLGILDGLDLDVKAVFLDREFYDSKCLTLLQAHNHAYVMPIVRWGQTIKQELSEGWSRVIQHDMTAKLDGHSWTVEFLVYIDCTYQNGRCDEHGVARHGYAADAPFIESPRDARYHYAKRFGIEASYRLSEQSIATTSTQNPVVRLLYVVVSLLLQNVWRYLHWEYVATPRRGGRRLWKWSFKEFINMIQRAAWTALATRRAVPANRPPDDRFTR TPA_BK010831.1 DAC79762.1 tpg 83525 84766 - XerC/D-like integrase Loose gnl|BL_ORD_ID|1706|hsp_num:0 FomB 34.29 3000449 phosphonic acid antibiotic antibiotic inactivation Fom phosphotransferase family fosfomycin MNQNTSSTRDGSTPLDDSFERYLQDKGKGRGGDGGNYRRNAARELERLAEWAAGDRGDDDWTGIVPDDVDRDPTFEDLDERVFREYARHLAGDRGLKQNTVQTYYRYISAWCGWCVNEGYLEAHYAQRASAMAPLPEDDGRKPGDQQAWTSEQRHTLTRHVDERARDAVEAYATLPADTDPLDKQRARYAALKAARDRALVFVLAYTAVRVGELLRDPNDPRRRGVRWEDLSLDDGSMDVYRKKQQWDAASLPDPVISPLRSYRQLMDPPTERWPVFPTFDHRTLATIVQDGLADQGERPDTITEQRDEYARNLLLALDEDVRPPSITTDGARSILQRLSDAAEIDIDHPKHDYLAPHGGRRGMGEVLVRAFGYTVAARYLDNSEEMVRERYSHIEAGELGDVATEALEEIDQ TPA_BK010831.1 DAC79763.1 tpg 84776 85381 - uncharacterized protein Loose gnl|BL_ORD_ID|3160|hsp_num:0 ADC-133 21.98 3006308 cephalosporin antibiotic inactivation ADC beta-lactamases pending classification for carbapenemase activity MASDDTRYPILVDTDALIAVANSPLWTEITDQIGLTTTNVCKQELKRHVENTRETAPEGSRPYQLHYGSRTALDALEDNETPLTQVTSVPRPHGADAGEESLRQEVLQNPGAVDYVILMDAAGRRSIRRAVDDQDEDIRVVTPPFLFYILYDNELISRCEFCEACGEMLEREGWTGYNAVKAAWEAIPIDCSDILDDHLLP TPA_BK010831.1 DAC79765.1 tpg 85817 86398 - HTH domain protein Loose gnl|BL_ORD_ID|4864|hsp_num:0 MCR-3.15 27.54 3007252 peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase colistin A; colistin B MASTYIKTKRERCCMTEDESNSVGLMERQTTGEDRVRMTARQLSEPRTANWIASEAGWSHEPTKRVLERLVDDGILHRDDSGTHTTYYPDHRRQAMQEAMRLRDSGHTVEELTDRLADMKTQIRDWEDEFDVESPNQLRGTLAEGDLDADEEDRRPEIAREWEHLQRRIQIVGFAIREWDFLAPTTEPAEASS TPA_BK010831.1 DAC79768.1 tpg 89038 89376 - uncharacterized protein Loose gnl|BL_ORD_ID|4827|hsp_num:0 MCR-8.3 29.69 3007227 peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase colistin A; colistin B MPLHDNFDYWSPIAAFVALSLFVILALARPALPVALALALGVTVFVAGISPAVRERLPSYNRLIGAYCGVFGLARFASEGWTSVSAALVLVGVVSVLELAYERMTGRSADIV TPA_BK010831.1 DAC79769.1 tpg 89703 90164 - uncharacterized protein Loose gnl|BL_ORD_ID|4670|hsp_num:0 TolC 35.29 3000237 macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump; major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; cloxacillin; gentamicin C; tigecycline; ciprofloxacin; spectinomycin; streptomycin; tetracycline; tobramycin; oxacillin; ceftazidime; ertapenem; piperacillin; novobiocin; azithromycin; rifampin; imipenem; chloramphenicol; polymyxin B; polymyxin B1; polymyxin B2; polymyxin B3; polymyxin B4; ampicillin; nalidixic acid; norfloxacin; cefalotin; triclosan; ticarcillin; gentamicin MPNGDRDDVADRLSRRFDNDEEADEVSGEEEQAANAQQPPHEENASDAGNEENEGGKMNAEAEVSSRNAMHVRNVKSEWTSKSFYLPEFLKDDLKTTYKETDLEFEMERGEELPKTRHYYPLVVALGIERIARMDPQEINERIEGLEERGEPE TPA_BK010831.1 DAC79771.1 tpg 91218 91409 - uncharacterized protein Loose gnl|BL_ORD_ID|1787|hsp_num:0 MexB 24.0 3000378 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole MARNQGPVTDEEFDELHEEMDEQRDQLHEDLAENLGGDSDDYDVRRDVDGSSSSGEAVTHGGE TPA_BK010831.1 DAC79772.1 tpg 91385 91681 - uncharacterized protein Loose gnl|BL_ORD_ID|2711|hsp_num:0 Acinetobacter baumannii AbaF 42.86 3004573 phosphonic acid antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump fosfomycin MGYSHSSGHLTLFVVQFEDGEWAIVVRSNHDPEREHGYDVAEKGVYLDVYRDEEKYRSEELFPPMQPSEALTYAKDQIPMQPERYGTRFEEWHEIRAQ TPA_BK010831.1 DAC79774.1 tpg 92420 92614 + uncharacterized protein Loose gnl|BL_ORD_ID|65|hsp_num:0 fusH 72.73 3003026 fusidane antibiotic antibiotic inactivation fusidic acid inactivation enzyme fusidic acid MSPLLLSLLFFSVVVEMEKRNPITDSTVLSDPGGQKWVCELFYDTLRGCNTAVVTSVARPQTNL TPA_BK010831.1 DAC79775.1 tpg 92639 93613 + DUF2800 family protein Loose gnl|BL_ORD_ID|3412|hsp_num:0 CSP-1 36.36 3006871 cephalosporin antibiotic inactivation CSP beta-lactamase MPFSVTWNTLLERLDALHEEATLITPLSNNRIRITDVQDQRVIIQFRDRDIDQTRPLQRDQFETLYRRITEESGEFNLDRLPPDADPYPAVLTIHPQFELDADAGVITQTEGETSTQLRDSDPATDVDDRTEPDLDVYADALLVVDALERHEVADLSELETDALGTLYTLLSDLQRDANDLRKDVADVLLSRLHHDRPVSAPFGSVQRTTRQTRSLKDDETVLAAFEDAGIDRDRVLGVDRNKVDDALEVTDLSESDVYDIEESEYVRKAEVDEERKETRLQGLKDQLAATEGDETDALQEEISALEDRIDSLTSFQTGTDLQE TPA_BK010831.1 DAC79776.1 tpg 93610 94074 + uncharacterized protein Loose gnl|BL_ORD_ID|1673|hsp_num:0 tet(36) 21.01 3000197 tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein tetracycline; doxycycline; minocycline; chlortetracycline; demeclocycline; oxytetracycline MTTYQFRVKFEYAPTELWRDIIVGADRTLDEFQTVLNRAVGLDQDHLWFVGTDQDYWDSDVQYKCPSEFEQSSDGLVRGGEEYDAGETTVGQMARRLDLDEHDRLCYLFDYGDEWRFYAILKEITEDEPRDTEPAVVNRKGDPVDQYAPPDERL TPA_BK010831.1 DAC79778.1 tpg 95437 96846 - DNA repair helicase Rad25 Loose gnl|BL_ORD_ID|3748|hsp_num:0 OXA-159 31.11 3001464 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-62-like beta-lactamase oxacillin MRLAFDDGTLLLEDAPNSVPYADWDDRVDEYRARALHYQDLCQWAQGPDGQATLNQASHTDESLHDDARAYRDLDLTPAVAIEPRDYQQAALAAWTDHDRRGSVVLPTGSGKTFLAVQAIADASVSTLVVVPTIDLLNQWHATLTNAFGDQLPHEIGVLGGGSHNVTDITVTTYDSAYRYINEYGDQFGLLVVDEVHHLPAPTYQQIPEMTIAPYRLGLTATYERTDGEHNVLEDLIGPVVYEENVDELAGEYLSEYETIHLKVDLTPEERNQYDDEYQIYRDYLDNHDVDIWKQDGYQEFLKRTSYDPDGRRALIAKQRAEEIARTAEKKLDTLDNLLKRHYNDRTIIFTANNDFAYDISQEFIVPCITHQTQTDERTEILERFRTGEYSMLVTSQVLDEGIDVPAANVGIILSGSASKRQYAQRLGRILRPTEDREPARLYELITDDTMEQYVSKRRRQGVTTNADS TPA_BK010831.1 DAC79779.1 tpg 97175 97651 + uncharacterized protein Loose gnl|BL_ORD_ID|40|hsp_num:0 SME-2 40.54 3002380 carbapenem antibiotic inactivation SME beta-lactamase MISTCRSQRGQAIKYAGSEQRGDMLPDDLSVDQDKLLTWQTECWQCGEQTPIVWPRDDHLNTPIGGVLAKYDTPVERVYSNTLEKEVWGNVCQHCEAYQGNHYMEQEAVAIDPPFVECPNCGEEHEWRPDEGFGAAFGQGWVSCPEYGDVPVGDPRKK TPA_BK010831.1 DAC79780.1 tpg 97984 101370 + plasmid replication protein RepI Loose gnl|BL_ORD_ID|298|hsp_num:0 vanR gene in vanF cluster 22.22 3002925 glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanR vancomycin MSGHHTIWLVGCSHCSELWFTAAGRKTTDCPRCRTTYRTRTLRKFAEDTDRDALVEKRTQILASRSDPRARDQYRATVDDALTDYDSLEDAAQSSLIDEAAVRRHIGADDAADLRSANDESTTSSSSSSGMEEPESEHTNSFDPLGIPLPVAADSGISRIPPEQDGQTDLSTTVVYRGLQPQMRRWIPSLLEDLLPTLTAAVAQWTVDQDTLTLEDANTEGIATALLDKLDIDPGTVEIDGDRQAPVEVRAWVRDLVAFTVRAVEEDVTINDAPESLTRIGTGRGLLNAGRAALRAGPVALLDVLEVTPQVAATLNEGEWVGTRKETRARSLGALDSLSDALDIQLVFSTPRMESLLVEDHPDWTSRHLNLTEDADTSYPSKTDTAAGEDAALAREAWDILREREWSGTGYTRILGNIPASGATRGDLAADDDVSLSEGSIYAYVDDLAATGFVTIDDSTRPSRVVLTELGASIADYVDAKGSVQNPVQASLTQSPNRGTSECTPQHQQDPPGDSHQLGDDRVSAAESFLARTGDVSEDGYTRFLGRYSGGTAPREIEPATLHHQLQAGRCTEGVSVVEDANLQKFDDGRVSYLSGGPSFDDDVAVVLEWGNPLGTLARLVGTLLGSRAWSKILRRSRLGSSLENLWAGADQFDSALADVAKFGAQMGWMSSREESDYLSYRERLEAVRCSLLEDVGRFDDLDYEQRSALLSKLIGLATTATTLYHAAGYDLTVHLRVPDSKQLRRDDDRYGRFLAFFRSVVAKQGVYRGPDGVHSIYRMQRERRSEKLKRRLGYEIDPGDPRAELTCSWVVAVDGTGGEVASDIEGALCVEDHRVRERIQEGTEEAAVMDVPVVVANGAETTRRIVEAFAMKKGFSAGARQDLDRLVNVIHAALGTQERAPSPFDVAAVMQALESKDEPSDKLDVGALARGIATLPANRLLPSLFDEGERPKLAIQKMVRALLGSDGAVSRGDLVEVSSQNSVDRYLQRLRALDIVERVGPGEYRAYLEPWWVSGNGQSEPYSEAYDGEIAATGLGDGRWDAVLLGAAHELGADTASAASVEAFSQPVVFEEVLEAHPVLEQYEHILRVYVDGVEEDGPPSTVARIGSPPPGTAPDQQTLTAAVSSD TPA_BK010831.1 DAC79782.1 tpg 102864 103040 + spurious ORF Loose gnl|BL_ORD_ID|2199|hsp_num:0 lin 47.06 3004651 lincosamide antibiotic antibiotic inactivation lincosamide nucleotidyltransferase (LNU) lincomycin MRLNGVELSTNTTMRCVGERERKIAETIRLVWINQRIDIHSEHTEQVRVTALLQLRSK TPA_BK010831.1 DAC79783.1 tpg 103281 103472 + uncharacterized protein Loose gnl|BL_ORD_ID|3539|hsp_num:0 GES-31 40.91 3006160 carbapenem; cephalosporin; penam antibiotic inactivation GES beta-lactamase MVHKIISRNPGNFGRVNVSTSDLEKLEIETSEDIDIDVADTEDVAHTFIDSKNVDRFLITTPQ TPA_BK010831.1 DAC79785.1 tpg 109051 111990 + ATP-dependent helicase Loose gnl|BL_ORD_ID|1350|hsp_num:0 AcrF 26.15 3000502 fluoroquinolone antibiotic; cephalosporin; cephamycin; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump ciprofloxacin MTDFEVGDHVKFAGGRGEITKIEDRPNGGQLLHIYTTEGKLRKLPSGLPHIERIDSIIDRLAARQIDSPIHHDLRERATRLDLAYRYDRFLSLTNNRIEIEPYQVQAAYEILNSYDHRYLIGDEVGLGKTIEAGIVTEELIARGRAQRVLIVAPAPLTVQWQQEMREKFDRNFVIYDRETVRTHRNSHPNQNVWLQEDLIITSIDFAKQDDVLEALRNLDVPWDLAVFDEAHHLTARRGSDESIERTQRYTVGEAVAENSDALLLLTGTPHKGKSDQFYFMVNLLDPYRFGHESQIHPDELDDLMIRRLKEDMYETDGTRMFPEKNIEALGVEMSPAERKLYDDVTEYIREYYNLAQQEENKAAGFTMVIYQKRLVSSIYAIQKSLENRMRAIQNDAVAEDLPDDVQELIPRYSTEPETLTDAERERVEAALETVTVTLNQSQIQEELDRVKQLWRQAKSIETDSKAQMLKQFVDRILTEDPDEKILIFTEYTDTLEYLRDRVFAEYDIAQVYGDLDQDRRRQEMADFENEKNIMIATDAAQEGLNLQFAHIMANFDLPWSPTRIDQRMGRLHRYGQERTVEIRNLFFKDTRESEILNLLVEKTDQIESDLGMRSDVLGRVLEDVDLDDTIMAAIAEDRPTDEVVADIDETIEERKNALETVENEFLIRDRFDLSDEDDEILDVIERSQHGDVSEDDIEVLVREFFDEFGGDIRGVRPGPARAGGDVFQLDVPDVLSGDQVAGRYEQATFTRQVAMEEDDVDFIALDHPLVQSLIEFCLDSNRIDGQVAVKVASDGEPAPGILFTYRLGYVSGAGEAVTEKLVPLYVTSESEVSTRKPEFVDTLPPGEVGSTPTLDQLTSMAEDLHSIAEMEAWEQVESFADEAREEREREVEIKRQHAEQHFEEEISEWEERLESYEQQDEQGKDMSAPIGNAKRELESLRRERDEELARLEEEKHVTPEEPELMTTSLVLDNQPGER TPA_BK010831.1 DAC79786.1 tpg 111987 112532 + TATA-binding transcription initiation factor Loose gnl|BL_ORD_ID|2390|hsp_num:0 TMB-1 39.13 3004105 carbapenem; cephalosporin; cephamycin antibiotic inactivation TMB beta-lactamase ceftazidime MTVEIANIVGSGDLGVELDVEPLEADLSTPYSEYDPSNYHGLYVRLEENGPLITVYRSGKYIITGCASMESLHETNEEFLGMLADLGVTEEDTQTGFTVENVVCTAMLDELVSLNALAIGLGLEVTEYEPEQFPGLVYRPEEIGAVLLVFANGKMVITGAKDTETAESAYEYFQSKVQELV TPA_BK010831.1 DAC79787.1 tpg 112954 113157 - insertion element protein (ISH2) Loose gnl|BL_ORD_ID|2305|hsp_num:0 tetA(46) 28.21 3004032 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MARTKMGVSIRTELVDELDSLVDECSDLGASRSEIVEAILTAYFQNDEDQIKQTRELIIRNRKRSNS TPA_BK010831.1 DAC79788.1 tpg 113327 114211 - uncharacterized protein Loose gnl|BL_ORD_ID|3514|hsp_num:0 EC-14 22.81 3006875 cephalosporin antibiotic inactivation EC beta-lactamase MTWRQATRKEIHAYYAEEFPRYLDDLPEFITATGPKQYAVAFRDSYPVRKDEVPDKGFIRRDTWQTDASEDRTTPEFEDFEDVVEFIRHPARNDPLGRSEFALADPEVLEQPDPRPDAVYYALDHWERPWVLLVDIDAKEIARERAADAVSDDVDDRDDEALLDAAGILDAEPTGYPYAFEDVNRAIEYGFEVRDIFEDDFDAEETMVVYSGQGVHVYLLDTDPAHRYDEQSHEVLNDLLLETYDIPIDPVVTADRRRVARLPYSLHADVCSIVQPIESPAFDVRSATPEVIDE TPA_BK010831.1 DAC79790.1 tpg 118019 120244 - uncharacterized protein Loose gnl|BL_ORD_ID|4852|hsp_num:0 MCR-1.19 39.02 3007240 peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase colistin A; colistin B MRNLVLQTGSGAVAQLTEWLTNPTSVEGTALYILLAVLVGTGRKFLWDWYSEDDEEEVEFSDLLDEETIEQGAAERQLLDDIAESHKTVTASAAIEWETRAAQVGEQWTTTLYIANYPDYPNDGYLSELFEMTDVQFDLTAHITPKNQERARNELQDIADDLQVDADLEQSVRSAYLQERANEAAATYKAVENGANVFDQGMFITVRADEKDDLQDAVQKVKSALRDDPANLTPKTAICRQDLALQSAAPIGDNEFGRTSIALGGAVGALLSSPHNATILEEGGVEFGIHKDNQSPVVIDPFARDNGYAMFTVGDTGSGKSFSSKQNFIRSVEQSKGRIGIILEPLNNWAGVAEALDAKRITVGGTLGLNPLEIRETPEHVQRAMGEDASPFNEKLDDAMSFLTNFFALRGISLGDRRTTLELGLKRAYKRNGITDDISTHDNPSPTIRGMMDVFEDMVNNPEEFVVRSDEEAGKIKEDATWLLDQLRPFEADGRHANLGQESDFDIRDEKVIYLDLAQQEGSVDSSTALTMQLLISLVYERAKVSEKEVVFYIDEARYIMQDAASLAFLETVFRHHRHHDLSIRLVTQTVDEFFEHAESEAILDQCAVKQFHRLDGMDEEWADEFGLNYAQMRFVQDAVPGNEDAGFSEALVGVDGEWRGIQVKAMPKEKQVIDFDPTSQVRSSLPGAGDEAVDTEMQEFQEKLEHRTTNGTDETSELNEDSDAVEAEPDGGSMEETNDG TPA_BK010831.1 DAC79791.1 tpg 120237 121358 - uncharacterized protein Loose gnl|BL_ORD_ID|1762|hsp_num:0 LRA-13 30.23 3002484 cephalosporin; penam antibiotic inactivation class C LRA beta-lactamase; class D LRA beta-lactamase MSIDQDAAARRIMDQFGEESRIPSLNIEEGDVGVLIAFPIVGLFVAGLTGIESLALPFVAGGFGFGVAIVYVSPDHLNAWTWTKDVYRYVKRPQITFSSPEEANSSTNETERNEGGLANYTPFKPDERTQDLTNIERAWPGAGAIQRADGTMEAFIEIDPDNMDFAMSDDWAQLQDAGEEFANKELDSELKLHATTRSFPVEQITETIEERLTDEDVTENPIFRELLEEYRETRPKEMRDRGIQQVRYYIGVQVSPIEVYDRFRDEGTPAEKLTQFPVIGFLFNPFVTRREDLTDVERRAQMFEKLDSRVNDVRSEFIQQASGWSARRLGTVELFVLNMDFWNGREHDYDEAERVVREQPIIGHSRREDAHDA TPA_BK010831.1 DAC79792.1 tpg 121887 122090 - insertion element protein (ISH2) Loose gnl|BL_ORD_ID|2305|hsp_num:0 tetA(46) 28.21 3004032 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MARTKMGVSIRTELVDELDSLVDECSDLGASRSEIVEAILTAYFQNDEDQIKQTRELIIRNRKRSNS TPA_BK010831.1 DAC79793.1 tpg 122374 123648 + ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|2034|hsp_num:0 vanJ 30.0 3002914 glycopeptide antibiotic antibiotic target alteration vanJ membrane protein teicoplanin MRRLTTLFPSEFLEEHAEELGVVERDRKLQIPVFVWAFVFGFAAGERRTLAGFRRSYNSTADEPISPGGFYQRLTPTLAEYFRDLVEHGLDEVAVPDTVDVDIDRFSDVMIADGTVLRLHEFLADQFEARHEEQAGAKLHLLHNATEQTIERIDVTDEKAHDSTLFKTGSWLENRLVLFDLAYFKYRRFARIDENGGSFVSRLKQNANPVITDELREWRGRAIPLEGKQLRDVLDDLDRTYIDVEVEVEFKRGPYNGTRSLDTKRFRVVGVRDEDADDYHLYVTNLSREEFFPADLAQIYRCRWEVELLFRELKTQYDLDEFDTSNEHVVKILLYAALLSLLVSRDLLDLVTEQADDELVFPPERWAATFRSHAQLILHELGEHLGYSPPPLLERLIEDAQKIHKQRPILQETLATATQPRCES TPA_BK010831.1 DAC79794.1 tpg 123755 125089 - ISH8-type transposase ISH32 Loose gnl|BL_ORD_ID|912|hsp_num:0 CTX-M-4 28.99 3001867 cephalosporin antibiotic inactivation CTX-M beta-lactamase MDSVTYSPPDSVIVDRIQRAFPSDELRERARATNLVERERKFDAVALFYTLSLGFAAGSDRSVQAFLERFVEMSDCDELSYATFHGWFSPPFVALLREILDDAIENLDTRNADLSGRLERFRDVLIADGSIVSLYQDAADVYAATGDDQAGLKLHLTESLSTGLPTRYRTTDAKTQERSQLPTGEWVAGALVLLDLGFYDFWLFDRIDQNNGWFVSRVKDDANFEIVEELRTWRGNSIPLEGESLQDVLDDLQRQEIDVRITLSFERKRGSCTSTTRTFRLVGVWNEDTEEYHLYLTNLSKDDYSAPDIAQLYRARWEIELLFKELKSRFGLDEINTTDPYIIEALVIMAAISLLMSRVIVDELRKLDVKQRESADDATASSPQLPRRRCSHAVERHSHLIQLYVMLDLGYELPDLDELLLWASRDPNPHRPRLREQVESGEFW TPA_BK010831.1 DAC79795.1 tpg 125296 127803 - uncharacterized protein Loose gnl|BL_ORD_ID|1897|hsp_num:0 mphC 33.33 3000319 macrolide antibiotic antibiotic inactivation macrolide phosphotransferase (MPH) erythromycin; roxithromycin; telithromycin; clarithromycin; tylosin; spiramycin; azithromycin; dirithromycin; oleandomycin MSRIDDSLTDLELIDLPALRLDEGEYERPETESVHTDLVQSGVGLEKDIGIITPTLHSGFLDYYALAAMFQDMSSLTLTFIVTPNTSVRDRYEQLRNGMQYSTERWPLATVKANKELSYRTEHVHSSDAPPGVIFTRFSTRLPNDEISSEIRTVLYDDAVKFEEERWEQFQSWQDRNDIPSVVYLIRDPLGPVYQRVKDDLDVVWAWTPTGIQSTLGDQQSSVDDDVPSVLETTNRERQFLKQKASGQTHRIHACTEGDVVEAFADLWSAFEELEDAADDIDEHDLYVAVGVAKRAINGFTRLLSSLEYSDNYRSKHGKATTLSGRVSQLEHIMDGLSGDAAAGRTPVEHVHHALSELRDTLTDTESQKWKRGAVLTAIQKVTDENEDLIIVLPDEPARQALQADLRIKLTDFYSEARSHVHLHTPQSLPNADPADYLLLYGPPKYDHRWLLRAPHAPDIGVLAYDHELGLLHSQVRDLNREMEHSTPDMSEAGLQTQILNTISAPAPLPENQENTASTTSSPTDPGQYDGVSIDIPDPDTEDNTQATPFDDYELVEGGSSESVDDLIEDHVPDFTGDATYTPDTTRSSTTNSREPTNDSRQVEGCIGIRVQDGKAIALPPTASLEVVNTDAGTIVEKPVSSIQSGDRVVVVEDRDRVRDEVEELLLDSGHIDLIGYARLWKNQLHTEIERRDDSLEDFIQRLEEQGLDKTRSTYRSWYYGDLHLPRAKDSLYALAQAYEIDEVLEEFENVWTANHKIRKIKRGFLDRLKHQSQEALAADEEGDPVIDEELDIRLSDLNPTDEAGTPFVQVYFVTEVADVGTFSRSQVGQWRDIG TPA_BK010831.1 DAC79797.1 tpg 131021 131923 + ParA domain protein Loose gnl|BL_ORD_ID|1481|hsp_num:0 SAT-4 28.07 3002897 nucleoside antibiotic antibiotic inactivation streptothricin acetyltransferase (SAT) streptothricin MAQSNTSKTPRAVCVGILKGGFGKTTTALNLARELAHRNEKALLVDLDDNGHLTLNLGHRDAYQNGSGGDNENHAEAVLVNEADPRDYIVNVAGGLDLFPSHADLEGVESTLKDAVQGSARLKQHLVEPLLGEDYDYVVIDCPANRGKLNDNAMFATGNLIIPLRPELGYETGLDNTVNRLVKPARRYFDLDILAVVPSDLQRRIDQATLDQELLKEITTRDGVASKVPNFAYISPEDWEATEAGEYDDGLPGIRHRDAINNSLRDANEPLRDFDRECDQLAAYDELAQIVEQGEVIRDE TPA_BK010831.1 DAC79798.1 tpg 131916 132377 + uncharacterized protein Loose gnl|BL_ORD_ID|2341|hsp_num:0 EdeQ 28.57 3004063 peptide antibiotic; polyamine antibiotic antibiotic inactivation Edeine acetyltransferase edeine A; edeine B; edeine D; edeine F MSDGNPFDDLNESIEDQDSEETEDSEATTTASTSTATSEETTSDDDTDESMTTGEQTVTEETADPFKTRAFEYGEEATQFPFYVREATLEAWQDADDVEITPALVQDGVKDVSTSEKHDAMVQMALDHPDLLVEYIKEARGIPDADTDTFSDE TPA_BK010831.1 DAC79801.1 tpg 135571 135942 - uncharacterized protein Loose gnl|BL_ORD_ID|2707|hsp_num:0 CAM-1 35.09 3004559 carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation CAM beta-lactamase cefoxitin; ceftazidime; meropenem; imipenem; doripenem; cefotaxime; ceftolozane MPRRVLLRSIGVCSAVGIAGCLSQGEARSITVYNYRDEMVTVDMRVVDVGSGDVAIDTEFSIDPDGKKVFGDIFERDGEKKITVSVPGVGSEEKTWSASSDPKTSGQLGISIRENVEIREGSG TPA_BK010831.1 DAC79802.1 tpg 136593 136724 - uncharacterized protein Loose gnl|BL_ORD_ID|4755|hsp_num:0 VAM-1 72.73 3007062 carbapenem; cephalosporin; penam; tetracycline antibiotic antibiotic inactivation VAM beta-lactamase tetracycline; ceftriaxone; ampicillin; cefotaxime MADLSQIMWLGTMVVAFLVVAGFYYTLVREGGAFLKSLRSKVR TPA_BK010831.1 DAC79803.1 tpg 137079 138353 + ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|3754|hsp_num:0 OXA-491 43.75 3005725 penam antibiotic inactivation OXA beta-lactamase oxacillin MRRLTTLFPSEFLEEHAEELGVVERNRTLQIPVLVWALVFGFAAGESRTLAGFRRSYNATADEPISPGGFYQRLTPSLATYLRDLVERGLDEVAVPNAVDADIDRFRDVMIADGTVLRLHEFLSEVYEGRHEEQAGARLHLLHNATEQMIERIDVTDETAHDSTLFKTGSWLHGRLILLDLAYFKYRRFALIDENDGFFVSRLKQNANPVITAELREWRGRAIPLEGKQIQDVVDDLSRQYIDVEVEAEFKRGQYEGTRSLDTKRFRVVGVRNEDADDYHLYITNLPRDEFLPSDLATLYRCRWEVETLFRELKTQYELDEFDTRNPAVVEILLYAALLSLLVSRELLDLVTEQADDEIVFPPERWAATFRSHAQLILHELGEYLGYSPPPLLERLIDDAQKIHQQRPILQETLATATQPRCEG TPA_BK010831.1 DAC79804.1 tpg 141211 141534 - uncharacterized protein Loose gnl|BL_ORD_ID|2872|hsp_num:0 CMY-147 35.71 3005180 cephamycin antibiotic inactivation CMY beta-lactamase MSSEPPSPPATLATEIVNTIDESDPEQLRDVASYAEALAEHKEREACLEESSDQEEVKERPDDLSDDVPAEATITIKEINDNRYYYWQWREGEKIRSQYKGPVNPDE TPA_BK010831.1 DAC79805.1 tpg 141888 142322 - homolog to endonuclease VapC Loose gnl|BL_ORD_ID|889|hsp_num:0 rphA 37.04 3000444 rifamycin antibiotic antibiotic inactivation rifampin phosphotransferase rifampin; rifaximin; rifabutin; rifapentine MPRALIDTSVLFAAAYKRDDSHDTALPALHGIDTGTLPEAVVLDYVLAETLNGLTTHAGHDAAVDLLDRIEENARFHIDSLTTSALATGKALFRQHEPLSFVDACIVAYMQTEGLGHLYAFDDDFDAVEDIYRLGTATNPYNST TPA_BK010831.1 DAC79806.1 tpg 142323 142574 - homolog to antitoxin VapB Loose gnl|BL_ORD_ID|1138|hsp_num:0 mphA 48.0 3000316 macrolide antibiotic antibiotic inactivation macrolide phosphotransferase (MPH) erythromycin; roxithromycin; telithromycin; clarithromycin; azithromycin; dirithromycin; oleandomycin MSSDRIDAESKVSGNQANIPARIRRELDIDDGDQLRWQLEDDGSIRVQVIQQQTGTFANFDGYAGEEVTDVTSNHDSWGVNVE TPA_BK010831.1 DAC79807.1 tpg 143029 143415 - spurious ORF Loose gnl|BL_ORD_ID|4767|hsp_num:0 PRC-1 34.15 3007085 cephalosporin; penam antibiotic inactivation PRC beta-lactamase cefazolin; ceftriaxone; amoxicillin; benzylpenicillin; ampicillin; cefotaxime MRIATAAWLSVNFITVLYRVHARLPPVIERPYRSIRVPGHEHCYATSLSQCFLDRFEHDLLESRLLFGCPNRGEIVCLGFLEDYLGRLWRFLKLRVHRHVWAQDVLCEFEEIIGVRSFFTSAIRIDYV TPA_BK010831.1 DAC79809.1 tpg 144372 146375 + Smc-like protein Sph2 Loose gnl|BL_ORD_ID|2244|hsp_num:0 vga(E) Staphylococcus cohnii 41.82 3004715 lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; pleuromutilin antibiotic antibiotic target protection vga-type ABC-F protein lincomycin; clindamycin; virginiamycin M1; tiamulin; retapamulin; valnemulin METNAVSLIYRCRVGERMSQHDTDGRVSVYAENIGGISQCDVTFKPGVNVLRGRNATGRTSLLNGLAGVLGGTAPVLKGDEQEAEVRLEFNGTTYDQQYTRKNGTVQAAGQPVTERRDLVDLFVCLTAENPARRAIVQDGNLRDVIMRPVDTGSIQRRIEDLQSERNRIGQRIRAIEDDLDQRTSLTSRKTTLVSDLDECDQEIEELRNQLEQFDADPEEAEEIEQALTSLEERKQELESITNRIRTQEDTREALRDEQSELQTEREAIETSEEELKRIETRLSELTSRERSLATTINDLSAIVDFNEDLVSNADSDLLRSGDAAESPVSKLNPMSETVECWTCGTEVERNRIAGRLDDLRDLVDEKRTERSEVQTEIEELRESQQELQEVIHRRDEIGQRLSEISSEIAQRDQTLESLSEEREDVHQRLSELEEFVSEREALQESELTEQYQQLSELEYQRGQLEEELSAVREELAELDRLENERDQLQAQQDEIQAELVSQRTQIRDLEESAITAFNDHMEEILDVLRYKNIARVWIERKEGAEFNSSHGGYRGGSATKFELHVVRETDEGRGYEDTVQSLSESEREVVGLVVALAGYLVHDVYEVIPMMLLDSLEAIDADRIAALVDYFADYAPYLIVALLPEDADALGGDETSVVPASFASEE TPA_BK010831.1 DAC79810.1 tpg 146432 147136 - TrkA domain protein Loose gnl|BL_ORD_ID|1160|hsp_num:0 MIR-4 33.33 3002167 monobactam; cephalosporin antibiotic inactivation MIR beta-lactamase MTTVIVGAGRIGSSVIELAADANIGVTVIEQEHERAHEFKADENCHVIHDDATERETLHEAEVGNADAIIATTDQDTTNLMVLMLARELGCETLVSVVHAEENIPLFRQLGATIIENPQRLIAEYLFRGTHDPGIQGFMHVGDRDGGAEVFEISVADGAPIIGKTLEQADVAGFLPPSMVVVAVERDGEIIIPRGNTQIETDDLVTVFSKEGIINEVVEPFKPEAKRTGDSDTE TPA_BK010831.1 DAC79813.1 tpg 149224 151383 + potassium-transporting ATPase subunit B Loose gnl|BL_ORD_ID|944|hsp_num:0 AAC(6')-Ib-SK 29.23 3002593 aminoglycoside antibiotic antibiotic inactivation AAC(6') amikacin; kanamycin A; tobramycin MAEITVTIDTDQQKQAISDSFAKLDPQYLVKNPVLFVVELGTIIGLVMTIAPGLFGATGSRVYYAVITVLLGFTVIFANYAEAYAELEGEAQADSLRALQTEAEGKLLQNDDVDIEDISEDDYEVVASTEIEQDAVVFVDEGDIIPRDGTVVEGSASVDESAITGESEPVIRQSGGDRTSVVGGTEVLSDRIKVEVTSEEGESFLDQMIGLVEDAQRQKTPNEIAMTILLSGLTLVFVVAVATMFFFGEYLASFVGGFAGLDVAELVALLVALMPTTIGALLAAIRVAGMTRVTRRNVIAKSGRAVEAAGDLDALILDKTGTITTGERVAQDFHPLGDADDADVVRASYQSSLYDETTEGRSIVKLAEKMNGKVQTDGGQSASEELDEPGDSVDAPRDVSVTLDAEGLSESNFVPFSAETRMSGIDLSDGTEIRKGAVDAVEEYATTVPGKLRQKSNAISESGGTPLAIAVDGQVVGIIELQDELKPGIADRIAEIQKMGVETIMATGDNQRTARWVADQVGIDEFHAEFDPEEKIELVEDIQDDGKLVGMTGDGTNDAPALAKADVGLAMNAGTNAAKEAGNMVDLDSNPSKIIEVVGIGKQLLMTRGSLTTFSVANDVAKYFVLLPAILAAAIPGLGAMDILNLSTPASAVTATLMYNAFIIPLLIPLALRGVDYKAQSGAQLLRKNLIVYGGGGLIAPFIFIKAIDMLFVALGVFQ TPA_BK010831.1 DAC79814.1 tpg 151383 152033 + potassium-transporting ATPase subunit C Loose gnl|BL_ORD_ID|2384|hsp_num:0 LpeB 22.81 3004100 macrolide antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; spiramycin; azithromycin MNRQDLAVPLRLLGVSLLVFGLLYQGSLMAIGDAVFPNSSAGSPVYVDGQEQPVGSQMIGQQFRPGQPEDVQYFWSRPSANDYNAMTSASTNWGPTNPLLSERVRADLQNISQYETPDDSVPVNLVSESGSSYDAHISPAAAEYQVLRVANQTGISEQRLNEMIDEATKEPWLGIWGHERVNVLELNLMVRDALNEQNETDQNSDMNASEIANGDH TPA_BK010831.1 DAC79815.1 tpg 152033 152851 + UspA domain protein KdpQ Loose gnl|BL_ORD_ID|2799|hsp_num:0 msrF 41.94 3005087 macrolide antibiotic; streptogramin antibiotic antibiotic target protection msr-type ABC-F protein erythromycin MSARNETGYERVLVPVGDKSDPNMLTELSSILVDPRRGAVRFTHVTTDRSFVGSQENWRTGSDSVAESQHTLREEGIESTGTIRTASSALDGILEEAEEYEADAILIGWTDKDSVSSLVDKLLRKAGCDVIVFSADRDPIDTDSILVPVVVKPDANRLQMLAIMSQRTGASITFTYVTGDEGTDEEGRGLLDQSAERLAEYGVQAETELKSASSAVDALGQLSEDYDVMVIGTSRGWWLRKTLFGRKTDKIAQEAQCSLLMHKWQGEVPPES TPA_BK010831.1 DAC79816.1 tpg 153263 153622 + uncharacterized protein Loose gnl|BL_ORD_ID|2241|hsp_num:0 vgbC 30.95 3003990 streptogramin antibiotic; streptogramin B antibiotic antibiotic inactivation streptogramin vgb lyase pristinamycin IA; quinupristin; pristinamycin IB; virginiamycin S2; pristinamycin IC; vernamycin C; patricin A; patricin B; ostreogrycin B3 MDRSHPPLGISVVSGIWLLMGLLNGAQTVRVVTTGPVSSELLLPLGLVSGVSIAYLVVGIGLWRTRSWAWKGAIVLAVIGIVGSFLQQPVGLLIALLLLCVGGYLILERDQFLSAEGAI TPA_BK010831.1 DAC79818.1 tpg 154368 155603 - IS1341-type transposase ISH35 Loose gnl|BL_ORD_ID|4305|hsp_num:0 PDC-243 33.33 3006621 monobactam; carbapenem; cephalosporin antibiotic inactivation PDC beta-lactamase MTELTKTLELKLVEPNAHKRRKLRETREAYQQALQDAFDAGCTTQTEANDVVVNYDLSGYAKNALKKYVPQLTTTYNAGELHDDHPVRFTNGGLRLDHKPENAIEWYVKIPHHEDYHLWMPAQPNPEQRDWLEALNAGDATMGESRLFERDGTWYLHVTATRDVEERSDVSAEERTPIGVDIGEASLATVCHRDGHGSPTAPELWADEGKTVRRLRKTYFTATRRLQTRGSERIVESFGDDIWDQIDDVFHRVTREVVEYAESVENPVLVLEDLTYIRESMDYGEYMNRRLHGWGFAKLHAQIRYKAVEKGIPVETVNPCNTSKECHACGEVGYRPRQATFKCTNDACWMGESQADVNGAINIADRYLSGESHSREHTDGDDSAGDGGRLTAPQDTLADATTQETLGTYAS TPA_BK010831.1 DAC79820.1 tpg 156312 157388 - DHH/RecJ family phosphoesterase Loose gnl|BL_ORD_ID|921|hsp_num:0 VIM-31 34.48 3002301 carbapenem; cephalosporin; cephamycin; penam; penem antibiotic inactivation VIM beta-lactamase MPELSETAERSQSNTPLAMIMDDSDIDYQRFQELVASTDSLAILCHDNPDPDTLASALALEAIAKEWEVPTVDIVYGGTVTHQQNRAMINVLDIELTPIDQVSLSDYGLVAFVDHGIPGQNNSAVEEMTPDIIIDHHPTDGLQGQFVDLRPAVGATATLLTRYLEIFSIELEERLATALLFALHRETLDFNRETTSTEHAAACVLHPHADHNIIEELTNSVFTPETISGIGDAIANREVRGSCLVSSLGWIRERDAVPQAADYLLQLEGVSTTIVYGIVDDNVHLSGRTSNSQLHIGNVMEETFDQVGSAGGHHDMAGGQVPLGFIGSVDDGDDVAIDLINQSMMARLFGALEGWTET TPA_BK010831.1 DAC79821.1 tpg 157391 158488 - UspA domain protein Loose gnl|BL_ORD_ID|2818|hsp_num:0 blaS1 35.9 3005111 cephalosporin; cephamycin; penam antibiotic inactivation blaS cefoxitin; carbenicillin; oxacillin; ceftriaxone; piperacillin; ampicillin; mezlocillin; cefixime MTEPMSIPVQRHDGTPKKSSIATHRPVSSQSYDLLVPLPDAKTADYNRLDIHRLLRTPLAIANDRNGSVTIASIVTAPSEISLDTVGNESFSEEMTRVIDLARDHVANVRDAVADYGEDVPVSGLVIVAHTPDDVFAECTTGERYDAVFLAQDNENGQQLWDESLLNMVLETADCAVYLETLGTKADPLLPDPEDATDRDDVSALDTSSNILLAVGPGPHTILGAETARALGSTYGTSIRGVHLYESTDAERFQQGRKALDLTEYVLSDFPDVECESRASEDVVAELLQEIEKYDVAILGAPTKQPLLQRLFGQSVPDELEPQPTTSILTVRQPSHALSSVYYRWKRAIERTSVGEDSPVLEDDF TPA_BK010831.1 DAC79822.1 tpg 158491 158670 - uncharacterized protein Loose gnl|BL_ORD_ID|4677|hsp_num:0 MexI 50.0 3000808 fluoroquinolone antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump acriflavine; tetracycline; norfloxacin MFSPIVLSLSTTTTMMYSPVAGWEADSTSVPHESNTLVNLTIRQEDRQSASNSSETPLM TPA_BK010831.1 DAC79823.1 tpg 159987 160157 - uncharacterized protein Loose gnl|BL_ORD_ID|116|hsp_num:0 rgt1438 45.83 3002883 rifamycin antibiotic antibiotic inactivation rifampin glycosyltransferase rifampin; rifaximin; rifabutin; rifapentine MNGYQPPLSDETSHREKTEQHADRLRLVYPHTPQCEWSTTQGTVIKKPLTAEVLMP TPA_BK010831.1 DAC79824.1 tpg 160229 160552 - uncharacterized protein Loose gnl|BL_ORD_ID|1499|hsp_num:0 MUS-1 43.48 3000843 carbapenem; penam; penem antibiotic inactivation MUS beta-lactamase amoxicillin; piperacillin; ticarcillin MSSEPPSPPANLPTEIVNTLNEATSEHLRDAASYAEALAEYKEREARLEEEADDADVEERPDDLPDDVPAKAAITIKEINDNRYYYWQWREGDSVTSKYREPVNPDE TPA_BK010831.1 DAC79825.1 tpg 161733 162011 - CopG domain protein Loose gnl|BL_ORD_ID|226|hsp_num:0 APH(3')-VIIa 23.68 3002654 aminoglycoside antibiotic antibiotic inactivation APH(3') neomycin; kanamycin A MSTDSDGGGDGEMEKINVRVPQSLLAQVDEVWEERGYATKSEFIRDALRDAVNPPTQLSEEALKHLAESREQREQGETVSQDDVKDRLRIDD TPA_BK010831.1 DAC79826.1 tpg 162134 162286 + uncharacterized protein Loose gnl|BL_ORD_ID|1806|hsp_num:0 vanY gene in vanF cluster 29.17 3002958 glycopeptide antibiotic antibiotic target alteration vanY; glycopeptide resistance gene cluster vancomycin MPEIDLNEETVNRLDNLRVDDESYDEITNELINIYEAEELTLSFAGDRLE TPA_BK010831.1 DAC79827.1 tpg 162287 162568 - small CPxCG-related zinc finger protein Loose gnl|BL_ORD_ID|2117|hsp_num:0 Corynebacterium striatum tetA 28.95 3004639 penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline; oxacillin; oxytetracycline MTLQPWLYTLVVVVGGFHVLAVLYAYWSKQSSDGGVEPADSTKKSVQTKEVDCPECGTTNEREYRYCANCVSELPGGGNIGRMPTAPVGRQIL TPA_BK010831.1 DAC79828.1 tpg 164190 166403 - AAA-type ATPase (CDC48 subfamily) Loose gnl|BL_ORD_ID|899|hsp_num:0 lmrC 30.93 3002881 lincosamide antibiotic antibiotic target protection Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins lincomycin; clindamycin; celesticetin MRLTVKQLKNRDPGSGMAVIDRDALQEIGVSSGDFVAIEGRNGGRTVARVWPSNTSDAGRGIIRIDGQLRQAANVSIDDRVEVEKTEVEPADRVTVSLPQNLQIRGDLGSHLREHLVDQAVRAGQTVAFPIGFGMFSGRSGRRIPLRVVDTQPSGTVVVQNTTEIEIADQSAQEVSVESGEPENTTAPALTYEDIGGLDDELEQVREMIELPMRHPELFGTLGIEPPKGVLLHGPPGTGKTLIAKAVANEIDAHFQTISGPEIMSKYYGESEEQLRDVFEEAEENAPAIVFIDELDSIAPKREDVSGDVERRVVAQLLSLMDGLEERGQLTVIGTTNRVDAVDPALRRPGRFDREIEIGVPDHDGREKILQIHTRGMPLGDGVDLDRYAENTQGFVGADLENLVKESAMHALRRIRPDLDLDEEEIPADILDSIEVTENDFKEALRGIEPSALREVFVEVPDVTWDHVGGLDDAKERLQETVQWPLEHADAYEQVALEPAKGVLLYGPPGTGKTLLAKAVANEANSNFISIKGPELFNKYVGESERGVREVFSKARENAPTVVFFDEIDAIASERGQGVGDSNVGERVVSQLLTELDGLEELEDIVVIATTNRPDLIDDALLRPGRLDRHVAVDEPDEAARREIFEIHTEDKPLAEDVDVDELVERTDGYVGADIEAVCREAATVAVREYVRATASAESANVDEIELSIEHFEQALEEVDSNAGSETQAFEKPAEAV TPA_BK010831.1 DAC79829.1 tpg 166469 166840 - Hsp20-type molecular chaperone Loose gnl|BL_ORD_ID|2719|hsp_num:0 tet(53) 40.62 3004589 tetracycline antibiotic antibiotic inactivation tetracycline inactivation enzyme tetracycline; minocycline; oxytetracycline MPLPTGSTSSWLQNSGFPSRLFETGRNDYELYEEDDEFVLSVEMPGFDPEEITVSWDEGVLNIAAEHEDETRSQRKTYHRRFRFPKNVEDDDIEAQYNNGILEVRLPVLTGATTRGKQIEVQA TPA_BK010831.1 DAC79830.1 tpg 166898 167248 - uncharacterized protein Loose gnl|BL_ORD_ID|2034|hsp_num:0 vanJ 28.57 3002914 glycopeptide antibiotic antibiotic target alteration vanJ membrane protein teicoplanin MTSGQAYRGERCMGGQLVYTPDGDLLDRHLHVLRRVPGGFDWGSETDEARIDQLAIALLADSSTKNIALEHYTSKLQVVSKYILRCSIHRFLSIPTTNHPVYATPHQCNNTYIFVF TPA_BK010831.1 DAC79831.1 tpg 167438 167806 + spurious ORF Loose gnl|BL_ORD_ID|1784|hsp_num:0 mtrD 33.33 3000811 macrolide antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; penicillin; azithromycin MEHRTELHDTLCEGERRGSRPQVVLAEEDRLIGPVDPGQPLRGLLDVAKNGLRELVANLVLGLLLVVPRPPGEDLLEVRNDFVEAAVLIFSVVRRTRSVSLTRAAGLFSPGTAWSSGPHNAE TPA_BK010831.1 DAC79832.1 tpg 167863 168282 + UspA domain protein Loose gnl|BL_ORD_ID|3335|hsp_num:0 CARB-24 24.62 3005560 penam antibiotic inactivation CARB beta-lactamase MAVLVPYDGSSPAHDAVEHAVETHDTDELVLLHVTELADGMLDAGVDIVQEQLKGLQNPASSEGLTEETQALLEDAALSFRMETTVGNPAREIVSFAEDNDITEIVMGSHGRRGVSRVLLGSVAETVVRRAPTTVTVVR TPA_BK010831.1 DAC79833.1 tpg 168445 169218 + uncharacterized protein Loose gnl|BL_ORD_ID|4673|hsp_num:0 vgbB 22.64 3001308 streptogramin antibiotic; streptogramin B antibiotic antibiotic inactivation streptogramin vgb lyase pristinamycin IA; quinupristin; pristinamycin IB; virginiamycin S2; pristinamycin IC; vernamycin C; patricin A; patricin B; ostreogrycin B3 MSRNKIALTGPYDGLEEARRACTADLKETSPELYDACNGYTESLIAEVSASGNAIPGSALTDDKDLAVFRQFIKQQHTEYWFADLNGRGSTADLGWDAFRSLVVRYAEHAYLNAFGAYRAATEQLSQIERSRQEVSELLAEIEGRLDGDSAAVIADGEATPQELLTSAKRTVATATQQLDTAQTEISNAHAYHAVGDCYQTEYDIESESFSDVSLADDADWFLQDLRHRRDRLRTRARWMRNDVSALKSRPAVRDSA TPA_BK010831.1 DAC79834.1 tpg 169432 170319 + stomatin family protein Loose gnl|BL_ORD_ID|2317|hsp_num:0 Enterobacter cloacae acrA 26.8 3004042 fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan MLNTTVMKSLQLKVGAVVGAFVLVTVLVGGGLAWNPVQEGNIEVVKEWGASTGETLEPGANVIVPIKQSTAVVPVRPQEYTMANEKQEGAEARDDSVEVLTNDGVSVNVDVTIRYRVNKTEAATFYDEYKDVSQAEARLIRPTTQDVLRTEGGDIDTTEIYTGAGQKQMAAAVKKALETEAVGSGLIIEAVQIRNIKLPGQYADAVEKKEVEKQNIEKKQNSIQVAKAEAERKRVQAKGEAEANEIVAESLKDNPELIKIRYIEALNQDNSTIYVGAGSQAGITLTKDVDEENKS TPA_BK010831.1 DAC79835.1 tpg 170319 170462 + homolog to HGPV8-ORF82 Loose gnl|BL_ORD_ID|1104|hsp_num:0 msrA 50.0 3000251 macrolide antibiotic; streptogramin antibiotic; streptogramin B antibiotic antibiotic target protection msr-type ABC-F protein erythromycin; quinupristin MAGRLIVFGLLWLGAIALVTVGAFRYFSERQRLSHEERMYDKRHDDE TPA_BK010831.1 DAC79836.1 tpg 170753 172111 + diaminobutyrate--2-oxoglutarateaminotransferase Loose gnl|BL_ORD_ID|1633|hsp_num:0 AAC(2')-Ia 40.62 3002523 aminoglycoside antibiotic antibiotic inactivation AAC(2') dibekacin; netilmicin; tobramycin; 6'-N-ethylnetilmicin; gentamicin MTDHDDTSNAALLESQRRRESNARTYPRSLPMAVTHAEGIEVTDAGGTTYLDCLAGAGTLALGHNHPAVTAELERLLAEDRPLHTLDITTPEKEAFVDALFDSLPASFANTAKVQFCSPAGTDAIEAALKLTKTATGNRSVLAFHGGYHGMTAGALSLMGDIDAKEPVSGLMPNVHHLPYPDQYRHPFGLPAGEHESIHTYIEHAISSPERGFTEPAAVVLELVQGEGGVNPAPDAWVQELRRITREHDIPLVVDEIQTGLGRTGETWSFEHAGIEPDVVTCSKAVGGGLPLAVVLYNEGLDVWEPGAHAGTFRGNQLAMAAGRVTIEHVIEQDLPAHADKTGARLRSALTDLEADFDVVGDVRGRGLMLGVEFVAPDAAGDERPPPDGDLAAAVKQACFERGLIIETGGRDSAVARFLPPLIVSSHQIDEIAARFSDAVTAVLSSSAEVSA TPA_BK010831.1 DAC79837.1 tpg 172108 173682 + diaminobutyrate decarboxylase Loose gnl|BL_ORD_ID|261|hsp_num:0 vatD 23.38 3002843 streptogramin antibiotic; streptogramin A antibiotic antibiotic inactivation streptogramin vat acetyltransferase virginiamycin M1; madumycin II; griseoviridin; dalfopristin MSPPRSAGANASTDTDPVALADRLFLGSDAGNDAYADAMEAACDAVLDVIGGAHGPYSGASYDRLRDRLADTTALPAEGHPLEDVLAAVREDVLANAVHPSDETCVAHLQCPPMVPALAAEALLTASNQSLDSFDQAPAATVVEERLIADLTALYELGPAADGVVTGGGTESNHQALLLARDDYVETVFGQSVREHGLPPAAQDLRILCSADAHFTAAQSAALLGLGEDAVVTIPTDGRHRMDATALRETVERLNDAGKHPFAVVGTAGTTDFGSIDPLSAVADVAATHDLWVHVDAAFGGALAVSDQHSERLSGIDRADSVAVDFHKLFFQPIACGALLVADGESFELMSRNAAYLNPAGDAVPNLVAKSTRTTRRFDALKPYVAFRTLGRDGLGALVDRTLALADDVAGLLRADPAFELACEPTLNAVTFRYRPVREHAHCDPGPWADHVTEAAREQLFDAGTAVVARTTVDDRAHVKFTLMNPRTTVADIQSVLVAFKGHAATIEAADRTAPITTAAGGDQ TPA_BK010831.1 DAC79839.1 tpg 175499 176209 + probable N4-hydroxy-1-aminopropaneO-acetyltransferase Loose gnl|BL_ORD_ID|1254|hsp_num:0 AAC(6')-Ib10 29.24 3002581 aminoglycoside antibiotic antibiotic inactivation AAC(6') amikacin; kanamycin A; tobramycin MTAPLPRITSDYAYRRPDPQIDRTVAFRRVALDRDLGRLHAWLTSDHVTPYWSLGAPLPAFHQAIGDHLEDDHVTAYVGCIDGVPMSYVERYWVAADPLADHYDADDNDQGIHILIGPPEYLGQGCGTALLRAMTALAFRHAATDRVVAEPDATNDAAIAAFERAGFEPRETFRFPHEDKDATRVVCDRERFVGAFSPGAIAANGPPADGPAVNHDDATHRCPSGEHGNSTLEADR TPA_BK010831.1 DAC79840.1 tpg 176206 177639 + probable 1%2C3-diaminopropane N-3-monooxygenase Loose gnl|BL_ORD_ID|2248|hsp_num:0 FosD 39.13 3004674 phosphonic acid antibiotic antibiotic inactivation fosfomycin thiol transferase fosfomycin MTESVHDLVGVGLGPFNLGLAALIEGSDDVPLDAAFLEQKPEFVWHDGMLIEGTTLEVPFLADLVTLADPTNPYSYLNYLREHDRLYEFYFYETFQIPRREYNDYCQWVAESLAAPRFSRRVVDITAIDDDATPANFRVTAVEPADEARSATDDDAPTHQYRARDLVVGVGSRPYVPPAFRDLPAPDVFHTAAYREHRAAVCDADSVAVIGSGQSAAEVVHDLLTRRSTSDRSPRVDWVTRSAGFFPMEYSKLGLQHFTPEYTDYVYDLPQPVKDELIPNQDILYKGIDPETSTRIYDTLYEQSIGGRDPNVGMIAATEVGAVEPTGGGRYRVDCRHRQTDTGFAFETDAVILGTGYHRPTPGFLSSLEPRLARDDQDRLAVDREYGVGGDLPGGLFVQNAELHTHGVGAPDLGLGAYRNAVILDRLLADAPYPVDRDTVFQDFAPEAYASHAPGGRVRDDDPTTPPAAGQPNDHHQ TPA_BK010831.1 DAC79841.1 tpg 177665 179491 + siderophore biosynthesis protein IucC Loose gnl|BL_ORD_ID|2002|hsp_num:0 TriC 43.24 3003681 disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump triclosan MNTYEDTLQDAVTADTWATVERSLLAKLLREFTYEELLAPERTTDTDRGGRYRLVLPAADDADTVRYRFEAEERLMDTLRVFPDTIERAPADADSWATATDPIRFLLDARETLDATELTTGHLIREYRNTLLADAHIEARSAPESFADCSYAEYESEMTGHPWITFNKGRLGWDYEDYRDYAPERRQTTTIGWLAVRTDRVTFETVSGLTPTGLLRGELGDQYDDFMATLADRGLDPQEYTLLPVHNYQWETTITSLYASELAADAIVPLGNGADSYLPGQSVRTLFNVDAPEKHNVKLPMKIRNTLVWRGLPGDRTEAAPRVTEYITDIRDGDPFLRDDCELVLPGEVAGVNYDHPAFSELEDNAYQYDELLGAVWRESITDAIPDSQQAVTLAALLHEADGTAVISEFVERSPLELSAWLTELFDTLLPPLLHYLYRYGTVFSPHGENTIVILDEEFVPTRLGVKDFVDDVNISDQPLPELADLDADLRRVLRSEPPNGLCQFYFCGLFVGVFRYLSDVLTAHHGYDETEFWTQVRDAITAYQAEFPELSDRFETFDLLQPTFTKLCLNRNRLTEEGYSDTASRPHAAEHGTVTNALHEVAGDADE TPA_BK010831.1 DAC79842.1 tpg 179492 180145 - TrkA domain protein Loose gnl|BL_ORD_ID|4793|hsp_num:0 tet(X3) 40.54 3004719 glycylcycline; tetracycline antibiotic antibiotic inactivation tetracycline inactivation enzyme tigecycline; tetracycline MTTNRDLIIAGGGRVGFQTAELLADRGHDVTIIERDTRVVDDIADQWMATVIEGDATNPAIIEQAGVDRADGIAALTGETGLNLAVCLAAAELTPSIRTIARIDHGVRDSYTRFVDAVVFPERAGARVAANEIIGDDVQTLADITGDLELMLVRVADGAPAAGKQLRDVRFPAGTVIISGADGQRIARPDTTLTPGSRYIIAVEPDVAGEAMDLIQG TPA_BK010831.1 DAC79844.1 tpg 181795 183054 - IS1341-type transposase HsIRS6 Loose gnl|BL_ORD_ID|2014|hsp_num:0 MexK 32.65 3003693 macrolide antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; tetracycline; triclosan MTTTTTKTLEATLAPPTTHKKRKLCDLLDTYRAGLHEAFDAGCETMTATSDVVTPYDLPYQAKAALCNYVPQLHGTYDAQELDDDHPVRLTNQAAEFDHSPERDYEFTWWVPQPGRGTNFWIPLRINPAQEGLWHDLGDGEASAGQLRLQRHRTSWTLHVTVEYPVEEPDYDATDDDDVTPVGFDIGEAHLLAGCAYEQGTPTDPLLINRGRARHLRKAMFTMLCRLQERDAAQWRIDERFDHSQNALTDIIEKASREAVEYAQQFEKPLIVLEDLAHIRESLDYGEWMNRRLHAWAFARVQQRIRDKAREAGIPVRYVRPDYTSQTCHECGHIGYRNGDEFRCQNEECWVSEYHADINAAVNIADRHDPWGESLPLKPAGDDISRDGSACDSAATPTEQSQPRQMTLGEVGSEPPAGS TPA_BK010831.1 DAC79846.1 tpg 183629 184282 + TrkA domain protein Loose gnl|BL_ORD_ID|4793|hsp_num:0 tet(X3) 43.59 3004719 glycylcycline; tetracycline antibiotic antibiotic inactivation tetracycline inactivation enzyme tigecycline; tetracycline MPQLKRFVIAGGGQVGLQAAGNLSSLGHDVVLIEPDEQRVAELSDAYVGPVIHGDATRPSILTQADLDDADAIAALTDDTSANLAICMEAQHLNPAIQTLARADTQCNEEYEEVVDATLLPKYLGGDYAADMLTGEDVRTLVYPTSDLDIIEISVAESAPVAGRRLDEIALPEGSLLISTADREHLAGPEMVLEPERRYVLAVEADVADEVRDLMRG TPA_BK010831.1 DAC79847.1 tpg 184326 184676 - uncharacterized protein Loose gnl|BL_ORD_ID|181|hsp_num:0 SRT-1 30.3 3002493 cephalosporin antibiotic inactivation SRT beta-lactamase MSDCLDSFLEQISVTTICNRNLEGHRSQGTPGTALSRLQPRFRSNPVSPTPGHCPLGRPTCLSQVVVTAFCNRSLYLLSVTAYCSGPLSQRHGCGGFPTSTTRYRPSSHLTTAVSG TPA_BK010831.1 DAC79848.1 tpg 184711 185703 + ParA domain protein Loose gnl|BL_ORD_ID|3358|hsp_num:0 CARB-49 38.78 3005583 penam antibiotic inactivation CARB beta-lactamase MITAVVYAESGGTFKTTMTANLAVALSRMDLDVLVLDLDPQTGNLTSLFDVGEDRSDPNADNLVKHILEMPDGDFASLIETSPEGVDIVPSHDMLSDFTSNLEQKITYETGVKDVSREEYPRYELLYRLLWEREQVNEQYDVVLIDPNARAEDLLYNAMYALRTLVAPVKPAGKGSLSLDGLEEMVGNMETELDIGVGLSCVVPCGVGQTNAHKQYRDRFETTDAFATPVSIGSRESLMDAMWEAHGSAFKVIEERWKTYEGDDGMVSERGKRRVPDRELETLETIWRLAGFIATDTFDATVPEELVLDIVDDGTETLQMAGNGHPEVAD TPA_BK010831.1 DAC79850.1 tpg 186108 186329 - gas-vesicle-associated protein GvpM Loose gnl|BL_ORD_ID|1605|hsp_num:0 vanO 48.0 3002913 glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; Van ligase vancomycin MNPTKRNSHAIVEFVDVLLRDGAVIQADAIVTVAGVPLLGISLRAAIAGMTTMTEYGIFDGWDADHRRRNAQP TPA_BK010831.1 DAC79851.1 tpg 186310 187149 - gas-vesicle-associated protein GvpL Loose gnl|BL_ORD_ID|1469|hsp_num:0 OXA-74 37.5 3001798 cephalosporin; penam antibiotic inactivation OXA beta-lactamase; OXA-10-like beta-lactamase oxacillin MTPAQSQARAQLSDGRYVYCVVDTTSVPSASVGETTGIDDETVRVVSVDGVGAVVHDCTSVYDADDIDQVKRWLVTHQQVVDDVSDVFGTPLPMRFDTVFAGGDSALTDWLADTHPRLRTELDGFAGCWEYRVTLLWDPQPFEAHVTATDDTLQALEARQAEADAGTTFLLEKQYDARLAERRRARRSALASDLSAAVEPVATQVASQDTTTSLRDESVSERHTPIARLAVLAPETDESALGSQLDDIAARDGVTIRFTGPWPPYTFAPDICTDEPNQA TPA_BK010831.1 DAC79853.1 tpg 187507 187803 - gas-vesicle-associated protein GvpJ Loose gnl|BL_ORD_ID|1784|hsp_num:0 mtrD 29.11 3000811 macrolide antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; penicillin; azithromycin MSDPKPTRSQGDLAETLELLLDKGVVVNADIAVSVGDTELLGVELRAAIASFETAAEYGLDFPTGTDMERVTAAAGVDADDSKSVLERPDPPTTEGSE TPA_BK010831.1 DAC79854.1 tpg 187800 188141 - gas-vesicle operon protein GvpI Loose gnl|BL_ORD_ID|1114|hsp_num:0 erm(40) 45.16 3004606 macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase erythromycin; clarithromycin; clindamycin; spiramycin MTPTNRHTHGQNAQHARRNAQQSRDAARRKLIAQHAALAEQRARNRRRSDTEQPTSDTTNPAAHSTLPAQRTNAQNAARNAHSTVPEQPTHATTAARARLYGLRLHNTATTDK TPA_BK010831.1 DAC79856.1 tpg 188629 188880 - gas-vesicle-associated protein GvpG Loose gnl|BL_ORD_ID|317|hsp_num:0 OXY-3-1 29.17 3002409 monobactam; cephalosporin; penam antibiotic inactivation OXY beta-lactamase MFVLDDLFVNPFLSLVDILQTMALDELYDTSEIRDQIKENQLLYEIGDRPADEYERRKQELEAQLRTAEQIRDQMRDRMEIKN TPA_BK010831.1 DAC79857.1 tpg 188883 189536 - gas-vesicle-associated protein GvpF Loose gnl|BL_ORD_ID|4806|hsp_num:0 blaC 37.14 3007182 cephalosporin; cephamycin; penam; penem antibiotic inactivation class A Mycobacterium tuberculosis bla beta-lactamase cefoxitin; amoxicillin; cefalotin; temocillin; ticarcillin MSESHLYTYGIIDDNESLALNVDGVAGATRAYTVSYRSLSAVVSDIETTDPERTDAAVEAHNTVLQAVLEHDATRAVVPMSFGMAFKNARTLKGVLRGARRALRSTLTEIAGTVELGVKVLAPGDDTAVDTAAVRSDVTARLSALSVGETENDCFTDRLIINKSYLVEHDTRDAFDAAIDEIDAAHDDLTVRYTGPWPPYNFVDIHIGAEQAQQGGR TPA_BK010831.1 DAC79858.1 tpg 189529 190110 - PadR family transcription activator GvpE Loose gnl|BL_ORD_ID|3286|hsp_num:0 ALI-2 31.58 3006895 carbapenem antibiotic inactivation ALI beta-lactamase MDDLLAELKSEMDAAGVDADVEFSLPTLELTAALDATIDDTSQLYTDDPPHHYTDTPLTGDDLPLLEAWLDDAQLHGVGDDIIAEYIDEVLLVLITVRGGACGKELLQDVRRLFGADVSPGTMYPHLKQLADAGLLEMSELTKRKVYRVADAQAAIEHVDSVVLQLLTFAVGLQTIMADCIVNQSADPQPQDE TPA_BK010831.1 DAC79859.1 tpg 190115 191593 - regulatory protein GvpD Loose gnl|BL_ORD_ID|2852|hsp_num:0 PAC-1 37.74 3005150 cephalosporin antibiotic inactivation PAC beta-lactamase MSARTPLHAPPSHEGIAHFPREIRRFFTGEPGQTLLVNGAPGTGKTLFTIRGLDVLSREGDVLYVSTRVDQETVYEMYVEGHAALDRTALLDLSQDPFGLPMDVDVPFETLNLESLLSWVDAISAPATKLTLAFDSWRLVYEYLAARHDSPPSIETVTNQLVALARDAGVRLVLVSETATQSPLEYIVDGVVTLHVTDNERGRTRRQLRLEKLRGVRIENRLQPFTLADGQFKAITPVELSTTQSVPDEATWEPLANPTARFSTGIRDLDTILSGGFNRGGVVHLDLGADLSRDAWSVLVLPAIRNFLANEMGVAVVPPKEGSPGLLHNDLSAVLSKAVFDTHCHVFETYAGPTRDHDDAVDPDRLPGHDTTPTEHGTLSYDPYIARAERIREHSDGPLLHVISMDTAYHAFETRLGDFANYVALHNDASVLITKPGTALRTRADRVADMHFRLECAGDAIVLYGETPLTPLLGIGVDQSGTIPEITLTEMV TPA_BK010831.1 DAC79860.1 tpg 191862 192101 + gas-vesicle major structural protein GvpA Loose gnl|BL_ORD_ID|689|hsp_num:0 cmeB 28.89 3000784 macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; fusidane antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; cefotaxime; fusidic acid MAQPDSSSLAEVLDRVLDKGVVVDVWARISLVGIEILTVEARVVAASVDTFLHYAEEIAKIEQAELTAGAEAPEPAPEA TPA_BK010831.1 DAC79861.1 tpg 192186 193043 + gas-vesicle minor protein GvpC Loose gnl|BL_ORD_ID|3282|hsp_num:0 AFM-2 33.72 3006891 carbapenem antibiotic inactivation AFM beta-lactamase MTVTDHREAMIEARAAVTDVREAMDAYAEEFAADVNSIRTDSRHRENIRDMRAAVDAYCESFATAVSTHHDETAALRADLEATAAAFDAYTTAFAADAAAMHDVSALHRDIEALREEFRAVTTDFEDYTTDEFAPAVGALHADAAETAASFTAKQEGFEAYRHDVHESAVPALTADIAATRADFDDTAASFAAYARAFYGHTDDATAQTDADDTTAQTDVLSGQATVTRAQPEEDDTPEDMVQCRVCEEYYQAITEPHLQTHEMTIDGYRDEYGEDVPLRPDDHA TPA_BK010831.1 DAC79862.1 tpg 193040 194074 + gas-vesicle operon protein GvpN Loose gnl|BL_ORD_ID|4984|hsp_num:0 Clostridium perfringes cplR 24.62 3007644 lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; pleuromutilin antibiotic antibiotic target protection Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins lincomycin; clindamycin; virginiamycin M1; retapamulin; iboxamycin MTDTSRNRKVRGSKIRSSRSDKRQSRGSEDKELKRLADARDTDSEQAGDRVGDAFIPDEQSFIETDAVARVTDRMRRWLSVDRPVHLIGPTGCGKTAVAMHVARTRDRPVVWVNGDADLTTSDLVGEYAETERISEHDQFIHNVVKRKDIVRDRWVDNPLTLAVQEGATLVYNEFSRTKPVANNVLLSVFEEGVLELPGKRGASRYVDVHPAFRTILTSNSVEYAGVHEPQDALLDRLVGLHMDFYDAETETAIVRAHVEAADVPVAAIVGMMRELRERLEITVGTRAAIMAAEGLTAADDPDADTVVDVCTDVLASKVSQRSDVEALRDVIEETLADRGVTLS TPA_BK010831.1 DAC79863.1 tpg 194097 194432 + gas-vesicle operon protein GvpO Loose gnl|BL_ORD_ID|2383|hsp_num:0 LpeA 28.26 3004099 macrolide antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; spiramycin; azithromycin MDDPVADQPDGTDETPDGDTAGSSPIGLADAQARAREAVAELLEHPFDGIITAESGADGGWRILAEVVERSAVPDTQDIIGRYEITLDDGGRVTGYELRERYRRGEMKEEL TPA_BK010831.1 DAC79864.1 tpg 194523 195221 + TrkA domain protein Loose gnl|BL_ORD_ID|1147|hsp_num:0 ceoB 30.56 3003010 fluoroquinolone antibiotic; aminoglycoside antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MQVIIVGAGTVGAPLVDVATGSGNEVVVVEQDGGRANEIADAYDCAVLHADATDESTIQDAGADRADALITTTGRDPTNLFVCLLGAEHDIPTVVSLLQRPAHRHLFAELGVYTVAGLHDLAAESLYRVARQPAVSESMPVAGDAAVFRITVGADAPIADTMLVDARSTGVLPDDVLVVAVRTGDGEAEIARSETTITPGDEVTVYSSRGTTADVTAVFSTDVREDGARGRF TPA_BK010831.1 DAC79866.1 tpg 196620 196934 + DUF2078 family protein Loose gnl|BL_ORD_ID|592|hsp_num:0 tcr3 63.16 3002893 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MIRHTGLAQMGPHHGAHGPMGGGMAGGLISTVLWLVVLAALVVAMGYLVVRVRRAMDDDGATGGDTAMAVLRERYAAGDIDDEEFTARRRTLERERDETPPKHQ TPA_BK010831.1 DAC79867.1 tpg 196969 197274 - homolog to autoinducer-2-degrading protein lsrG Loose gnl|BL_ORD_ID|2779|hsp_num:0 LptD 33.33 3005059 carbapenem; peptide antibiotic; aminocoumarin antibiotic; rifamycin antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump novobiocin; rifampin; imipenem; polymyxin B MIVVHATFRFDPDARDDALELIADLVEQSQTEDGLIDYRAAVDVSDPNVVRFFEQYEDAAAFDAHSQTDHFQAFEQQLPELLAGEPEIRRFDVDSVTEPPL TPA_BK010831.1 DAC79868.1 tpg 197387 197656 + uncharacterized protein Loose gnl|BL_ORD_ID|1017|hsp_num:0 ANT(6)-Ib 37.5 3002629 aminoglycoside antibiotic antibiotic inactivation ANT(6) streptomycin MAQHGTVKVPDGKLVSVSLTANDRITSVRVTGDFFLEPPEARPHLERAIEGHPVDVDAATLREAIADVDARLIGFEARDLAAATMEAIA TPA_BK010831.1 DAC79869.1 tpg 197653 198399 + lipoate--protein ligase domain protein Loose gnl|BL_ORD_ID|2386|hsp_num:0 OXA-267 24.71 3001723 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-213-like beta-lactamase oxacillin MTLRVITDGTYSEPVQQALERVLADKVAAGDIGPTLRVWYRDAPAVPIGRFQSYEDEVATDYVERHDIDVVRRATGGGAMYVEPGAVLTYSLYLPPEDVPDDVADSYVYLDQWAIDALQAVGIDASYEPLNDIVHADGKLGGAAQLRTDGAVLHHTTMSYDLDIERMLRVLRIGEEKLSDKAVASAEKRVAVMTDHTDASRATIVDALVAAIGDTFETRRGSLSAATREAARTLAAEQFDTAAWTRKL TPA_BK010831.1 DAC79870.1 tpg 198414 199433 - amidohydrolase domain protein Loose gnl|BL_ORD_ID|4812|hsp_num:0 vanX gene in vanP cluster 24.3 3007190 glycopeptide antibiotic antibiotic target alteration vanX; glycopeptide resistance gene cluster vancomycin; teicoplanin MTELAGTVLAGDAFEPTRGRVVIDDGRIDAVEEDTHVDSEDIILPAFVNAHTHLGDSIAKEAAVGLSLDDAVAPPNSLKHRRLAAADDDDLVAAMRHTLTFMHQTGTVACLDFRESGRPGTEALRAAADTVDVTPFIFGSGDPDVLDIADGYGASGANDNDFADERAACTRRDAPFAIHAGEPDATDIHPALDLEPDLLVHMVHAEDTHLTRVADQSVPIAVCPRANTVLDVGDAPIPALLDHTTVALGTDNVMLNPPSMFREMATTAKRFDVSATDVLRMATTAGAEIAGLDCGVIEPGRRAALVVLDGDSHNLRNAVDPVQAVVRRATGLDVKRVLT TPA_BK010831.1 DAC79871.1 tpg 199555 200640 + FtsZ family protein%2C noncanonical Loose gnl|BL_ORD_ID|1039|hsp_num:0 tet(J) 55.0 3000177 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MRVVAIGVGGAGGRIVDALHEDDSTREASYLAGGSVLETDRGALAALDAVSEEDRHHFGHSGFGGDADSPRERIEALAEDDHVEMRRAVDSAITSDAAAIIVIAGVGGATGSVIAPKLTDALQRIYDRPVYAVSVLPATHEEVPPENPARAIAAFESAANAQLVFDNDAWVDDRNDVEDVTDGLNAELAMRLGALFSAGEAVTAESVGQRVVDASEVISTLDEGGLATIGFARQPLGTDGDDGSLLDRARELVGMDETTVDEVESIKAVETTLRQATNGRLTFDCPRDAARSGLLVVSGPPEWLHQTAVSDGQSWLADEIGSVQLRTGDNPMPGGDELTILVLLGGIRGAPRIKEIQAATD TPA_BK010831.1 DAC79872.1 tpg 200714 202105 + SNF family transport protein Loose gnl|BL_ORD_ID|1011|hsp_num:0 AAC(3)-VIa 36.0 3002540 aminoglycoside antibiotic antibiotic inactivation AAC(3) sisomicin; 6'-N-ethylnetilmicin; gentamicin MVDRDSWVSNVGFVLAAVGSAAGLGNIWRFPWLTADNGGSAFLAMYLLLVVGIGVPGLLAEFVLGRRGRQTPIGALRSLIGSRWGTAVGTFNVITTVVMLSFYSVVGGWILRYTLLSPTGAYFAQPQQYFSHASHGLPAVGFHLLFLGIIALIVFFGVSQGIERVSKVMLPAVVVLLGGLAVWTATQPNTAAGYAFYLGFDPDYLAANFFSVLGPAAGQALFTLSLGAGAMLTYASYLDDDASLPRDTVVIAISNTAIGVLAGLVVLPLLISQGITPGQGGPGALFVALATAFGALPGGNVVATVFFFTVLLAAVTSGINLLETPVATLVDNYNASRRVATAAVTLLLAATGSGLALAGPAFRFVSGPVVDVMLTLGLLAFLGIVGWVLREEAAAEFRAGAGRLSGLATPWVVAVGWVLPVVVVFSLTTTVASITGVSLTNTTRAAIAVGVAVACRTAVTRTA TPA_BK010831.1 DAC79873.1 tpg 202141 203145 - ABC-type transport system permease protein(probable substrate zinc) Loose gnl|BL_ORD_ID|234|hsp_num:0 VIM-8 31.58 3002278 carbapenem; cephalosporin; cephamycin; penam; penem antibiotic inactivation VIM beta-lactamase MTDVIVQPAVIEPLLGPLYWLLGVWSQLMTGVARATGLEVLQYGFMHRAILVGLCIGVMAPLIGTFLVHRQLALIGDALAHTGFAGVAIGLFLNAVFEFGISPYLTAVIVAMVAALLIEVISETTDAYNDVSMAIVLSTGFALGTTLISINAGGLAVGVNQFLFGNLSTVSTDSAAILLVLFTIIIGVVGVTRNQLLYVTFDETAAAVSGLSVNWYNRIMVMLTAMVVVGAMQIMGVILVAAMLVVPVAGASQVARSFNESLLVSVVLAEIAVVLGIAVSYYGEATAGGVIVLLAVGVYVLAVLAGKLQTALTGTETPEMGAISPNSDPTTTDD TPA_BK010831.1 DAC79874.1 tpg 203145 203906 - ABC-type transport system ATP-binding protein(probable substrate zinc) Loose gnl|BL_ORD_ID|2240|hsp_num:0 tetA(58) 32.86 3003980 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MTPHHDNTADTPAIELADVAFGYTATPVVEDISLAVSPGEYIGVVGPNGSGKSTLMKLMLGLLRPDRGRARLFGVPAHQFDTGSRIGYVAQHASASKEMPITVREVVKMGRFPHVGFGQLSADDWAVVDEALDTVGMSAFADRRVTELSGGQRQRAFIARALAGEAELLVFDEPTVGVDIESVAAFYDLLDVLHDDGITVVLIEHDLGAVTEHAERVICLNRELHFDGPTAEFVDSDALARAFGTTTAVLGDD TPA_BK010831.1 DAC79876.1 tpg 205403 205837 - uncharacterized protein Loose gnl|BL_ORD_ID|1241|hsp_num:0 dfrA22 44.12 3003018 diaminopyrimidine antibiotic antibiotic target replacement trimethoprim resistant dihydrofolate reductase dfr trimethoprim MSRQRTRRDIIRTAGTTAAGLAVVSGSAVASENTAQSESVQPTSTKSFSITFEVASNGGTGGYRAEVPDSDATCETVDTGFLGNDTVKRYDSKTIVQGKVKPDKEDEIKFDTDDGERPPGDDWWSADPGVDVTLDTPSGSETLQ TPA_BK010831.1 DAC79877.1 tpg 206380 208347 + OPT family transport protein Loose gnl|BL_ORD_ID|2014|hsp_num:0 MexK 45.45 3003693 macrolide antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; tetracycline; triclosan MPQDPSESPSTADTNRTTNDHTRPGPAPTVPAGKNVAELTVKAVLIGLALNVLLLTANMYLGMRSGLTISASIPAAVISMGLFYALRYAGIGGTILENNIVQTMTSAGEALAAGVIFTIAGVTFLDQSINIVETAAVAALGGLLGVLFMIPMRRYLIVDKHEQLPYPEGTACADVLETGSEGDGGVKLISLGFFVSFIYMWLANGMAVMKTTLETAFSAGQTRGFAIGGDFTPALIGVGYIIGPRIAAYVFGGGLVAWMMLIPLLITGGFVPDQAANLTLMGQAHAVWDQYVRYIGAGAMIVGGFYAIISMAGTIRDALASAAAELSGSKSETATQIPRTQRDLSMKVVVLGALAITIALVAIPQVELGVLGGVIAVVAAFLFVAVSAYLVGVVGSSSNPVSGMAVATVLIAALAMKSTGVSDPVVVLLTASVVAIAAAVAGDTSQDLKTGYLLGATPRKQQIAQMVGIAISSVFAGWVLSFFNQAYGIGSETIPAPQAGMMALISEGVLTGSAQWGMILIGAVFAIVLIMMDVPVLPFSVGIYLPITLATPIFLGGLLRAGVDRYVDWRSDDGDGAAKERATYRGRIIAAGLITGEAIMGIVVGGIYVLGIGADEGAPYAVGLASGTQTLLGGVALVALVAVFVGGVIRDPQDT TPA_BK010831.1 DAC79879.1 tpg 208894 209991 + glycerol dehydrogenase Loose gnl|BL_ORD_ID|1787|hsp_num:0 MexB 48.0 3000378 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole MTSVFKSPSTYVQGRNVTTDIGTHAESLGDTALLVADEIVMDMIESDVHESLAEAGLDGSSVVFNGESSEDEIERIASVAVDEGADIVIGAGGGKALDTAKAVREEVGGAMVSMPTIASMDAPTSSLSVIYSEHGEFEDYWYYEQHPDLVIVDTEVVAAAPARFLRSGIADGLATWFEADAVAQSGGDNEVGGKPTRAGHKLAELCYETLREHGAGALDAVEHDAVTESVDAVIEANTLLSGLGFESGGLAAAHSVHNGLTQLAETHDATHGEKVNIGTITQLVLEGHSDARIEEFIEFSVELGLPVTLGEIGITNPEQVDLDVVAEAACDEAETIHDEPFDVTPAMVRDALLTADEMGRRVRDR TPA_BK010831.1 DAC79880.1 tpg 210588 212033 - Orc1-type DNA replication protein Loose gnl|BL_ORD_ID|4721|hsp_num:0 salD 54.17 3007028 lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; pleuromutilin antibiotic antibiotic target protection sal-type ABC-F protein lincomycin; virginiamycin M1; tiamulin; retapamulin MAGRDQGGTHGVGDDAGVGGDDAAADGSGHGAGSQLAGSDAATDEDAQRSIRDMLHDDGDASVFVNRDLVEPDTIIDEERIVGRDEQLESVVSFLKPTLQGNRPPNMLLYGPAGTGKSLIIGAVTQQIIELCHSKGERFGVVQVNCQPINTLDQAVYELVQTVASDVGIEPGVPETGVSTKRKYRRLYDLINEHYDSVIFILDEIDLLVGRRANDEPAYSKLLYQLSRASNTNDIEGQVSVAALTNDPKFMENIDGRAESSFNPRDIYFPDYDATQLRQILENRRDAFRQDALTDDVLPLVSAFAAQSHGDARKAIDLFRGAGDLADEQGDQTVREDHVRESQDEIDKDRSLKLIAGLTTQKKISLYATAAVAHCSSATRNSVPSPVGFQVYQWVTEEIDADQMTRETYVKYVKELSTYGLVSTARKSRGRGGGMYMDFTFRGDPESMMHRVVDDTRLERVGTESERLHAVVNAQLREFEE TPA_BK010831.1 DAC79882.1 tpg 212395 212721 + NifU C-terminal domain protein Loose gnl|BL_ORD_ID|36|hsp_num:0 mdtP 26.09 3003550 nucleoside antibiotic; disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump acriflavine; puromycin MSAGNLERQTRNYLSDNVPQIQQHGGNFEIREIDEAAGTATVAIGGACSGCGIAPMTMNAIESRLPESLDDLDDVTVVRSGGPRAAVMPSKTDRMEDMDEYQDYSPPF TPA_BK010831.1 DAC79884.1 tpg 213229 214620 + ABC-type transport system periplasmic substrate-binding protein (probable substrateglycerol-3-phosphate) Loose gnl|BL_ORD_ID|1213|hsp_num:0 evgS 25.81 3000833 macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; cloxacillin; tetracycline; oxacillin; norfloxacin MAPTTETRRATATRRAVLAGAGTAGLTAFAGCGALNTATTQSDTGSSTITLDFWHVFGDELATTIEQMAADFSAQTDGVSINPVSKTGYRETLNQSLQASRAGDPPGIVQLFEIGTRIALDSNAFTPIDSLLPEDKIDREDFLPSVLNYYRTDGTLNSMPFNSSNTIMLYNKRAFEAAGLDPNAPPTTLAELRTAASTIVSNTQLEYGLTWPNHSWMQIEQQFAKQNQLLVNNDNGRAGRPTETNFDSDAGRAVYQWWTDMANADLYLNPGIEAWDEARQAFLTEQAAMLWDSTSNLVSLVAGAKQRGFELGSAYLPTPTGDNSGVVIGGGSLWVPDALTTAEKQAAGAFIAYLTQPDQQLRWHRNSGYFPVRQSVIDRLTDDGWFDEHPNFRTAFDQLQETTDTPATRGAVMGAFPEVRTINEELSVSIITGDMSVSAGLAEMDTQATSAIQDYTDSIDDSA TPA_BK010831.1 DAC79885.1 tpg 214632 215525 + ABC-type transport system permease protein(probable substrate glycerol-3-phosphate) Loose gnl|BL_ORD_ID|3878|hsp_num:0 OXA-628 23.91 3005849 penam antibiotic inactivation OXA beta-lactamase; OXA-184-like beta-lactamase oxacillin MSTQPTPFDSTLQALGLLLPSVVVLGAFLYYPGLETFRLSLYRTLFLGQQTAWVGAENFVQLLTSTAYHHSFAISVLFAAIVVTGTLLLSIAVGYLLFTVSVGSSAYLIAAIWPYALPPAVAAILLNFILHPNLGVFTHYLEAVTPFTLDWFNSGPQAFTVVAVVAIWKQLGYNIIFVVAAFNTIPKTLTERATLDGVGHLRRLRSVYLPLMAPTLVFLTVMNTIYAFFSTFPIVDLLTSGGPGDATNLLIFKLYRDAFEFNSLGLASAESVILFALVAVLMYVQIRVSEGYAQYGA TPA_BK010831.1 DAC79886.1 tpg 215530 216393 + ABC-type transport system permease protein(probable substrate glycerol-3-phosphate) Loose gnl|BL_ORD_ID|2408|hsp_num:0 AxyY 27.27 3004144 macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; cefepime MATDTAQSSTRTTHRDILPENALMHLGLFGAIALMAAPLVLAVLMSTQTTAEVYQPTTIGPGSNALQNYQAALTTYNFGTYLLNSLVMSIAVVIGKVTLSLLAALALVYYELPYERAIFMFVLLTLLLPVPVRIVPLFQLMADLGWTNTLLAITGPYIASATAVFLFRQHFRSIPDSLVETAHVDGVGPFRFLVSVLIPMSRSMIAGVCVITFIYSWNQFLWPLIAVTDKPSQVAQVGIRYIQGAAQAGLTQWGVIMAAAVLALLPPLAVLLVFHRSLRETIAIQQS TPA_BK010831.1 DAC79887.1 tpg 216399 217538 + ABC-type transport system ATP-binding protein(probable substrate glycerol-3-phosphate) Loose gnl|BL_ORD_ID|2803|hsp_num:0 RanA 27.69 3005091 aminoglycoside antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump MSTITLTDLTKHYDSIAAVDGIDLDVLDEEFLVVVGPSGCGKSTTLRLIAGLEDATAGTIRIGGTDVTDSPPEDRDIAMVFQNYALYPHMTAAENMTFGMQSVTDYSSAEIEDRVADAAATLGITELLDRTPDALSGGERQRVAIGRALVREPSVFLLDEPLSNLDAKLRVHMRAELSKLHRELDTTTVYVTHDQTEAMTLGDRVAVLNDGTVQQVAPPQQLYDFPANQFVAGFIGEPAMNLVPVRVRDRPRGLVADHEGFAHPLPDGGSNSALVDRRLTFGVRPEDVLLAGRSATGHEESFEARVTVREPLGEQLLLHCTIGDDELQVKVQPRRDVSTGDTIRLCFDQQRLHLFDPETGDAIYHAASEDQPAKPTPSQ TPA_BK010831.1 DAC79888.1 tpg 217672 218577 - uncharacterized protein Loose gnl|BL_ORD_ID|3122|hsp_num:0 ACT-76 41.94 3006270 carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation ACT beta-lactamase MTAIQQVLWELWMDYIGHPYYVSGNAILHALGQHLDPEIHGSVSASHGVFVPGQFGTFPEEHTQSGIRPYLGSGLPDVKAYDDLFLQREAMHPWLLDTRARDALNTHDLRVHGGHPALAHETIMGRREDQRKQQQTTKWYVHAYLHADDPTVLPLGEDVLEGLQFGGKRNYGYGEVQLKDTQMVDLDELDYSRLEGAETYLIELVTPFVVESEYPDADDRPVPWWWAENRDGLRLREEKILEQREVFRLETVDHGQVVKYLGDRPVETAKNGLTRVGSHSRYGFGELRLKPLGEQYQESEK TPA_BK010831.1 DAC79889.1 tpg 219561 219773 - uncharacterized protein Loose gnl|BL_ORD_ID|961|hsp_num:0 MOX-1 27.27 3002182 cephalosporin; cephamycin; penam antibiotic inactivation MOX beta-lactamase MSMKTSAGLQDSGTANESNPENEEADSALAELIEQHENTDWSDVPGISAAEAGAWTARLIEARESTPEGL TPA_BK010831.1 DAC79890.1 tpg 219985 220194 + HTH domain protein Loose gnl|BL_ORD_ID|1860|hsp_num:0 CTX-M-104 36.36 3001963 cephalosporin antibiotic inactivation CTX-M beta-lactamase MEADELIESDRKILDELQKGRCTPAVLVDWTGLSKQTIHNRLNVLVAAGHVEKAHESGLYELVSDPRDD TPA_BK010831.1 DAC79891.1 tpg 220233 220511 + CopG domain protein Loose gnl|BL_ORD_ID|4746|hsp_num:0 mreA 30.95 3007050 macrolide antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump erythromycin; spiramycin; azithromycin MSTDTPGDNGEEGEMVKLNVKVPKRLLDELDELSEELNYTNRSEFIREVLRDTTEPILTPGAQEGVSEGYADVAAGRTMSTDEARERLGIDD TPA_BK010831.1 DAC79892.1 tpg 220522 220821 + RelE family protein Loose gnl|BL_ORD_ID|22|hsp_num:0 lnuA 47.06 3002835 lincosamide antibiotic antibiotic inactivation lincosamide nucleotidyltransferase (LNU) lincomycin; pirlimycin MAHEVVLTETLVETLEQFETEEAERIINKLEDIGDFPGHFLDRLKNHPGYKLRVGDFRVLIEWDKDNEVIYAIDAFERKKEYRELGKYREVWGSWRDDE TPA_BK010831.1 DAC79893.1 tpg 222515 222757 - uncharacterized protein Loose gnl|BL_ORD_ID|1478|hsp_num:0 L1 beta-lactamase 44.0 3000582 cephalosporin antibiotic inactivation L1 family beta-lactamase MDRGIDNIRRNDRAQSAMHAVIINSTGVQVGPTTEESYSRQFELVRGWKNDENLSPGVRRFARNLEGDLYDTVDEDIDSI TPA_BK010831.1 DAC79894.1 tpg 222849 223370 - ISH14-type transposase HsIRS44 Loose gnl|BL_ORD_ID|2498|hsp_num:0 Enterococcus faecium chloramphenicol acetyltransferase 22.42 3004456 phenicol antibiotic antibiotic inactivation chloramphenicol acetyltransferase (CAT) chloramphenicol MRNQELLTETLNTANLECWERERTAKPSRVAVDETAIKINGEWSWLYAAIDLDTKLILDVELFGRHGTDPAAAFLHGLREKHDLSDAVFLVDQFGYRTALSRLGLNGRVDYIDRNLIEKWFHTFKMRIARFHNSWVGSRASAREWIEQFVHYYNRQRPHQPLDERTPAEAVLN TPA_BK010831.1 DAC79895.1 tpg 223741 224679 + DMT superfamily transport protein Loose gnl|BL_ORD_ID|1932|hsp_num:0 Mycobacterium tuberculosis gidB mutation conferring resistance to streptomycin 42.22 3003470 aminoglycoside antibiotic antibiotic target alteration antibiotic resistant gidB streptomycin MSRYRTTGRFLLLCAVWGTAFMATDVGLADLPAVPFAAVRFDIAAALLFAAVFVSDADVYPRTMDDFVYVLVGGTLTIGAHHAFLFTGQQYVTGGVAAVLLGLVPVVTPALTRLVATDEQLTAATAVGVMLGFAGVVIIANPDPTNIADSVLGVSLVLASAFAFAVAAVVTHSRSPSLPFLSTQAWLMATGAVVLHVAVLVLPGQSFAAATWTPSALGALTYLSVVAGVGGFLLYFRLLDDLGPIEMSFIEYVIPVFAALAGWLVLGQEITPATVVGFAFILSGFLASKWRALRLRSVVVTTISSFTGPRDD L79F TPA_BK010831.1 DAC79896.1 tpg 225010 227172 - catalase-peroxidase Loose gnl|BL_ORD_ID|1953|hsp_num:0 Mycobacterium tuberculosis katG mutations conferring resistance to isoniazid 56.78 3003392 isoniazid-like antibiotic antibiotic target alteration isoniazid resistant katG isoniazid MENEDHNFGTSDWWPNQLDLEILDQNSQQVDPYGEDFDYAEAFEDLDLAAVKDDLEEMMTDSKDWWPADYGHYGPLFIRMAWHSAGTYRTFDGRGGAAGGRQRLPPVDSWPDNVNLDKARRLLWPIKQKYGRKLSWGDLIILAGNVALESMGFETYGFAGGRKDDYTPDEAVDWGPEDEWETTSGDRFDADGSLKWPLGNTVMGLIYVNPEGPNGEPDLEGSAKNIRESFGKMAMNDKETVALIAGGHTFGKVHGADDPEENVGAEPAAAPIEKQGLGWENEFGEGKGPDTITSGIEGPWNTTPTQWDMSYVDNLLEYEWEPEKGPGGAWQWTTKSGELNESAPGVQDPTDTEDVMMLTTDVALKDDPDYREVLETFQENPREFQQSFSKAWYKLIHRDMGPSERFLGPEVPEETMIWQDPLPDADYDLVDDEAVAALKSELLESELSIPQLVKTAWASASTYRDSDKRGGANGARIRLEPQRSWEVNEPEQLEAALSTYEDIQAEFNDARSDDMRVSLADLIVLGGNAAIEQAAADAGYDVDVPFEPGRTDATPEQTDVESFEALKPKADGFRNYLGDDAEREPEELLVDKAELLNLTADDMTVLVGGLRALGVTHGDSELGIFTDQPGTLTNDFFTTLLDMDYEWEAASEDREVFELRDRETGDVEWTGSRVDLLFGSNTRLRAIAEVYGSDADEELFVQDFVDTWSEVMKLDRFDLE R463L, A234G, A379T, A431V, A139V, G300W, S140N, G279D, T275V TPA_BK010831.1 DAC79899.1 tpg 230000 231550 + 3-oxoacid CoA-transferase Loose gnl|BL_ORD_ID|2206|hsp_num:0 AAC(2')-IIa 37.5 3004628 aminoglycoside antibiotic antibiotic inactivation AAC(2') kasugamycin MVTQQSRREAVACVESGDTVGIGGFVATGIPEAVLAALGDRYERTRAPQDLTLYQPAAEGDRQGHGVSHLVQEGMLERTIASHWGFTPDLMAAVVNNEIEAYNLPFGVLDHLLRDTAAGKPGTITHVGLDTFVDPRRDGGKANAVTSEDLVERVTLNGTEYLFYHAVPIDVAVIRGTTADEHGNVTMEREALASNMLALAQAAHNTGGRVIAQVERVTSAGTLAPHDVAVPGVVVDSVVEASPEDHPQTYGSAYDPAHSGTVKPPTPSTDPLPIDERTIIARRAAMELDAGAVINLGVGIPELVSTAAAEGGVGDAITETVESGPVGGAASGGIEFGTAVNHDALVSSPQQFDFYDGGGLDVGFLGMAQVDAQGNVNVSRFGSQFPGCGGFINITQNAAAVVFCGTLTTGGLSVAVADGTITVTSEGAHSKFVEDVEHVTFSADHALETDQSVVYVTERAVFELTPDGLTLTEVAPGIDPGAVIAQLGFDPAVADPLGVMPARLFADAPPDLTDVV TPA_BK010831.1 DAC79900.1 tpg 231569 232591 - HypE family protein Loose gnl|BL_ORD_ID|799|hsp_num:0 adeB 25.0 3000775 glycylcycline; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump tigecycline; tetracycline MTSQIGKIDAEFFAQHLSPNLGADDDAVTVGPQYGVDFGVLSIGGQRLVVSADPVSVNPGVGIERAGRLALHSVLSDVAVSGVPPSFLSITLVLPASARDDTIAALWDAMATECERLGVSVVTGHTARQDVSFPWIGGATAMGVGDPAEIVRPDGATAGDTVLMTHSPGAEVAGLFAALFGDHLDVADDTVERADARLEDTTVVGDACAAASAPVTAMHDATECGIQGALVELATAAGVSISVSSDAVPVPEDVSAVCADLGLDPWQVSSRGTLLVTVPEAHADTAMAALDARNTPVAAIGTVSEGSGVTVDGTQVVHPGSDPAWTVFSALQRDAAARSP TPA_BK010831.1 DAC79901.1 tpg 232702 234123 - alkaline phosphatase Loose gnl|BL_ORD_ID|2776|hsp_num:0 LpsB 28.95 3005051 peptide antibiotic reduced permeability to antibiotic Intrinsic peptide antibiotic resistant Lps colistin A; colistin B; defensin MPTPHTTESPSVDRRTFLAGLSGAVAGGAVASQFQTTARAQATASPAANAIAYIVDGMGQTQISAARYLNAYKTAPERFPLNVSPAETPTGFDAFSSRGSMTTFPDDPYETTTDSAAAATAFASGVKTYNGAIGGVQTSGGGFQRVDTVLERASAQGYATGLITTTEATHATPAAFAAHVEDRGNQTEIARQYIEETQPDVILGGQRRDFEADASNGGTLVDAARDNGYTIAETAAELDAVDDPPVLGLFSQESHLDYYLDRKNDPENTQPNLDAMVDAGVDLLSSAGDPDKGFFLLVESGRVDHAGHANYPAQVAEQYEATQVAGQLVEYAETTAEPTFLVSTGDHECGGLTLGRDSPYEVEYDVLAAQKATTSRLRDLLAGVRSADELESIVAAHTGITALTDREVAKLRDAPGSISTILAERAGIAFTTDGHTGTDVPVFAHGPNAARFDAARDNTAVADALAAALGVSL TPA_BK010831.1 DAC79902.1 tpg 234261 235574 + DUF21/CBS domain protein Loose gnl|BL_ORD_ID|1649|hsp_num:0 DIM-1 25.29 3000848 carbapenem; cephalosporin antibiotic inactivation DIM beta-lactamase MSATSLAVGRIALALLLVVLNGFFVAAEFAFVRLRSASVETLVQDGRRGATAVKEATDNLDDYLAVSQLGITIASLGLGWVGEPAVAVLVDPLLEPVLPAPVRHTVTVALGFGIVTLLHVVYGELAPKTIAIQRAERVALVVAPVMKLFYYVFLPGTILFNGIATRSVQLIGVSPETEGHDTHTEPEILSVLSEASAAGRISPAEVSMIEHVFSLDDTTVREIMRPRPDVTSVSADTPLPELRTMAASGEYTRYPVTEGPDDDVIGFVDVKDILRASDAIDESGDVTARELSRPVVVVPETLRVDELLAEFQAEHRQMAVVIDEWGAFEGLATIEDALEVIVGDIRDQFDLATHAQSIEPRDDGGYEVPGAVSITELNDHLGTDFENEAVETVAGLVVSRLGHAPTVGDRAVIDTHTFRVTGVDGARITSLTVTPDS TPA_BK010831.1 DAC79903.1 tpg 235629 236318 - 7-cyano-7-deazaguanine synthase Loose gnl|BL_ORD_ID|2742|hsp_num:0 VMB-1 24.24 3005015 carbapenem; cephalosporin; penam antibiotic inactivation VMB beta-lactamase ceftriaxone; amoxicillin; meropenem; imipenem; ampicillin; cefotaxime MSAKRAVVLASGGMDSATAAAVAHNAGYEVYMLHTSYGQQTEHKEHECATAQAAALGAADFLHLTTDHLSKIGASSLTDDEMAVADADMESDEIPTSYVPFRNANLLAMATSYAEANDCEAVFIGAHSEDFSGYPDCQPAFFEAFQQTVAAGTKPDTEISINAPFVDWSKTDIAERGLELGVPYEHTWSCYRAEAPACGTCDACAFRLQAFQNLGERDPIEYAERPSYT TPA_BK010831.1 DAC79904.1 tpg 236436 237209 - 7-carboxy-7-deazaguanine synthase Loose gnl|BL_ORD_ID|2408|hsp_num:0 AxyY 23.45 3004144 macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; cefepime MPVSETTDRQASNGGDGPALPINELFYSLQGEGKLAGTPSVFVRTSGCNLRCWFCDSYHTSWEPTHATMSVDDIIAEVQSYEHADHVVLTGGEPLLHDDAVVLLDRLAALGYHTTVETNGTIHRDAPIDLASVSPKLASSTPTAETDPKGDGEWAARHDARRIDVATLGALADDYDTQLKFVVTDPSDMPEIESLLAEIRTATDTRIGDEDVVLMPEGTTHAELDARRNEVATLAMEHGYRYTPRLHVALWNDAPET TPA_BK010831.1 DAC79905.1 tpg 237209 237661 - 6-carboxy-5%2C6%2C7%2C8-tetrahydropterin synthase Loose gnl|BL_ORD_ID|1256|hsp_num:0 ANT(2'')-Ia 25.0 3000230 aminoglycoside antibiotic antibiotic inactivation ANT(2'') dibekacin; sisomicin; kanamycin A; tobramycin; gentamicin MRSAQSKRSQSTATGERTLHIGRDRPIRISAGHRLQHHDGKCSRPHGHNYEISVEITGQLTDEGWVVDKGTVTAVVSDWDHRFLLEDGDPLVDAFREAGDGDAVVVLEQPPTAEVMGVVLERKLHDALPETVSAVSVTVAETPALTAGPN TPA_BK010831.1 DAC79907.1 tpg 239394 240326 + aspartate carbamoyltransferase catalyticsubunit Loose gnl|BL_ORD_ID|4810|hsp_num:0 vanH gene in vanP cluster 28.38 3007188 glycopeptide antibiotic antibiotic target alteration vanH; glycopeptide resistance gene cluster vancomycin; teicoplanin MDLDHIITSKQLSRADIETVLDRAAEIDADPSAFADRYENTVLGLLFFEPSTRTKMSFDTAMKRLGGDIVDMGSVDSSSVKKGETLADTVRVIEGYADALVLRHPNQGAAQMASEFVDVPLLNAGDGAGHHPTQTLLDLYTIRENAGLEDLTIGIMGDLKYGRTVHSLSRALTNFDVDQHFISPESLQLPRDVVYDLEQESGTRVREHDSFEDVLPELDILYVTRIQRERFPDENEYQKVAGEYQLTATHLEAAKDDLTIMHPLPRVDEIAPEIDDTDHAAYFEQAHNGVPVRMALLDLVLSADGGVDDE TPA_BK010831.1 DAC79908.1 tpg 240319 240783 + aspartate carbamoyltransferase regulatorysubunit Loose gnl|BL_ORD_ID|1219|hsp_num:0 tet(32) 28.17 3000196 tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein tetracycline; doxycycline; minocycline; chlortetracycline; demeclocycline; oxytetracycline MSSDQHLQVSKIQAGTVIDHIPAGQALQVLQILGTNGASDDQITVGMNVTSERHHRKDIVKIEGRELSQDEVDVLSLIAPDATINIVRDYEVDEKRRVDRPDVVAGVLSCPNPNCITANDEPVRSGFDVLDDGMRCQYCEQIVSEDIPSLIDPE TPA_BK010831.1 DAC79909.1 tpg 240914 242809 + arginine--tRNA ligase Loose gnl|BL_ORD_ID|404|hsp_num:0 dfrG 37.04 3002868 diaminopyrimidine antibiotic antibiotic target replacement trimethoprim resistant dihydrofolate reductase dfr trimethoprim MLYNLRQELLAGIRAATSDAGYDYEVDQSAIELEDITDEEKGEFSSPISFSIAAAAGAPPVDVAAAIADAHRSNGLPAEVEAVTVEGGHINYHADTTDLADATLSTILRDGSEYGTRTDADPDTILADVSSPNIAKPLHVGHLRNTILSDAVMNILEARGHDVTRDNHLGDWGVQFGNLMHEYTEFGDEATLEDDAIEHLLDLYQQFEQRDSMLADLEDDETVTDQFADAVTEERDYHADSGKEWFTRLEQGDEDATALWERFRTVSIDRFKQTYDDLDVAFDVWNGESFYAQEGWNDVIIEKAIENDVAMRGEGESVYIPVYPDDYENVGDPQAADVDASLDRARQMREANDDLEDADFDPFYIVKSDGSTLYGTRDLATIEYRIEEYDADQSVYVVANEQNQYFQQLFVAARKMGYNDIKLKHIDYGLISLPEGSMSTRKGQIITAREVLDRAQDRAEEIIAEKGRIDDAEAQSVATKIALATIKYEMVAAKRERDTTFDIDESVALEGDTGPYVQYAATRGYSILDGADAAPEIDDLDPSVFNDTDVELLFELARYPLVLERCEERYDAAPLAHYLLQLAHVFNSFYHKNAVLDAENARTERLLLTKATTQIFDNGLGLLGIDVLEEM TPA_BK010831.1 DAC79910.1 tpg 242960 244417 - arginine/ornithine antiporter Loose gnl|BL_ORD_ID|1925|hsp_num:0 tet(35) 33.33 3000481 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MVEFEPRSYEDFDPEKRPSFGQALLPIAGMITFLAVGIVLLGLDAQMPLLWGIAFTGVIARYGWGYTWDELFDGISNSIVMGLGAIFILFIIYMLIASWVDAGTIPFIMYWGLEFLTPAVFVPLAALLSFVVATAIGSSWTTAGSLGIALVGIGSGLGIPAPLTAGAILSGVYMGDKQSPLSDTTLLASGVSDVDLWDHVRGMFPNTIIVGVISLALYAVLGLMAETGGTGGTGAEVAQIQGGLAGTYTLSVLVLLPLVITFGLAIKGYPALPSLGAGVFSAAGVSILIQGRGFAEAWQIIYSGTGPKTGVDLVNNLLSTGGLEGSIWVITIVFGALSIGGILEATGVLSVIAHNTAKAVDSVGGATLVTALGPLVINALTADQYMSIVIPGMTFRDLNDEYDLDGTSLSRTLEETGTVSEPMIPWNSGGVFMASALGVPVLSYLPYYFVGILSPILVVIMGFTGWKMYMKDPEESPEESADTAA TPA_BK010831.1 DAC79911.1 tpg 244821 245708 - ornithine carbamoyltransferase Loose gnl|BL_ORD_ID|602|hsp_num:0 vanY gene in vanB cluster 38.71 3002956 glycopeptide antibiotic antibiotic target alteration vanY; glycopeptide resistance gene cluster vancomycin MEHLVDINDVESEEIEQLLDLAASMKENPGEFSGVMDNKSLVMLFAKPSTRTRLSFETGMTQLGGHGIFFEMGSSQLSRGEPISDVSQVMSRYEDAIMARLFEHDEMMELAENADVPVVNGLTDFLHPCQALTDMFTMQEKDRLDTLAFVGDGNNVAHSLMQASAKMGVDCRIATPEGMEPDEEIQDRVSDANVTVTNDPYEAVDGATAVYGDVFVSMGEEEQREEKLAEFDGFQIDQDLMDAARDDAIFMHCLPAHRGEEVTAEVADGPQSVIFDQAENRMHVQKAIVHTLVNQ TPA_BK010831.1 DAC79913.1 tpg 246927 248387 - arginine deiminase Loose gnl|BL_ORD_ID|2548|hsp_num:0 OXA-273 34.43 3001729 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-213-like beta-lactamase oxacillin MSSESPESVDDSTKVQATAEWDPLQAVRMHLPGAETFVGIMDPEPNLFLNDFSLVDAQQEHLSLSQDLEAALPASNPIHYLHDDLANGNGMNALLSSRVNFDLSELGEDEQVNRRDKMWARLHELSPHTQIQAVLGNAEVIRHHSHSDEEVPGSNPDRWDTTSVQLEQPLTNMYFQRDQQFVTQNGVVLCSMKEDTRKPEVDIARASWEALDGDEFDVDIVADMSQVREHDVTEHVPERDDIQETEVLVEGGDFYPAGEFSLLGVSAKIPEGEAYPKHDIAEDDTEYVHRTTYAAGHRLLMDDAFGSEEVGLVRAPFEAAQAHKDDDNGEVEMDIMHLDTWFNFVDDDLVVAHKELVENTTLDVYARTHGGEKPYTLERPDVNFGEYLREKGFEIVDVYDYVDPSHPDTDMALKAITNFLTVGPRKILPVRFSDDDDGVMKQFIDGIQEDYDVTVIPDGEGRKIINLRAGYGAIHCMTTPLRRTPE TPA_BK010831.1 DAC79914.1 tpg 248466 249257 - IclR family transcription regulator ArcR Loose gnl|BL_ORD_ID|2179|hsp_num:0 efrA 22.92 3003948 macrolide antibiotic; fluoroquinolone antibiotic; rifamycin antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump erythromycin; ciprofloxacin; rifampin MDPEAANNGEPRRITSVLNAVEIIDAIKEHRGITLQELTTELDLTKATIHTYMATLRQVGIVEQDGDGTYQLGDWFVPVSNYARNSTDLYRLGREEIDKLATQTRHTAHLVTESDGRQIVLYESMGEESVTTEYHLRMRETPRKLHTSAAGKSILAFLPEGRRETLISEIEFGTESSTPIGSPDALREQLATVRDQGYAINDEEEIHGIRSIGAPIRGRTEDVAGAVSVTAPKTRLQNAEFAGEVPALVMEAANIIEVRLETA TPA_BK010831.1 DAC79915.1 tpg 249604 249831 + uncharacterized protein Loose gnl|BL_ORD_ID|2227|hsp_num:0 TaeA 35.48 3003986 pleuromutilin antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump pleuromutilin MCTDSCRHCFECLLHDTLGFIRCLLGEFEHIKQRAKVETHTGIRDGLLVARVERHLGCDGPNNAWMIRTISDQQV TPA_BK010831.1 DAC79917.1 tpg 250596 252485 + Smc-like protein Sph1 Loose gnl|BL_ORD_ID|2239|hsp_num:0 MuxA 29.41 3004073 macrolide antibiotic; monobactam; tetracycline antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; tetracycline; novobiocin; aztreonam; kitasamycin; rokitamycin MWNVDVTCIGGIRSGEATLRPGPNIVQASNFQGKSSFLAAIQTAIGTTGLLTEDHPLMENEDDGKVTLETDEETYTVSLTRATDSDEPAISRSGTPYLTRDQDQIAARLFAVLGEDNPIRAAVREENQERLTELLKKPLETENIDLRIEALQREIKELEDEVAAAEAASADLPAAQQKVTRLQGELRDLNETRDELERKVDEETDQRALRDELTAKQSDLEREEARLERLENQVDRRKAQLDDKEAALESLDIPDSPTAEADIAEKQTRIDELAVKIDLLDDLHRSTKAIIDEGEIDLITDVERTLSGDTFSCFVCGAETTAEAVTERLNEISDRQESLREQRATLTEEVTQMQQRTREIESKRQQKAELEDEIKRLRVDIQEDQHEVRSIEATIEELQAEIEQREAEYEAAEKAGESHSAELKTIQQKIGSTETKLDRAQAELERIEAELQKRNDRQEQLETKRDELETLRQRRKQKYNELVNQFDAAMADIIGRFAPGFDGAYLDQKTDANDTVGFEINLARDGHTTDLDTLSEGERELVGIVTALAGYRTFSVGDRVPCILLDGIGQLAAEHIRHMIEYLENTAEILVTTAYPEAGSFDGETVSPEHWDVISHETAQSRDHPQITN TPA_BK010831.1 DAC79919.1 tpg 254500 254730 - uncharacterized protein Loose gnl|BL_ORD_ID|2778|hsp_num:0 ArnT 48.65 3005053 peptide antibiotic antibiotic target alteration pmr phosphoethanolamine transferase colistin A; colistin B MVKNTLTDVRNELEEDLRRPLLGYTLLGLTTGISVLATGELLSAAAVPESVVVAGVLLIAGAVPTFTWYVLRKLGL TPA_BK010831.1 DAC79922.1 tpg 257176 257967 - ABC-type transport system ATP-binding protein Loose gnl|BL_ORD_ID|315|hsp_num:0 bcrA 39.91 3002987 peptide antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump bacitracin; bacitracin A; bacitracin B; bacitracin F MTDHLAITTDDLTKEYGDTTAVSGFTLAIEAGHVYGFLGPNGAGKTTTIRMLTALTEPTSGAGHVAGHPITNRQAIIPHIGYLPELPPIYDELTAREQLEYHGGLRDMDPVEIEDRIEELLDRFDLTGDADDRISTYSKGMKQKTGLVQALMHEPDVVILDEPTSGLDPRAARTVRDTITELAAGDRTVFLSTHILPVVAELATEVGILYDGELVAEGAPEELKDRMEAGGESTLEDVFLEVTTDEAYEADESPSDTGVSRSA TPA_BK010831.1 DAC79923.1 tpg 258585 260222 - uncharacterized protein Loose gnl|BL_ORD_ID|810|hsp_num:0 APH(6)-Ib 26.09 3002658 aminoglycoside antibiotic antibiotic inactivation APH(6) streptomycin MNVRSWLRHALQIARIERTRNKRQPGHSATWRALRMITLIVLSIGGGTGAYLIGKLIARGDFTLPVSAIQTAAVAGFITFLSLGIQRTSSVNERLDTGYLLTTVGAHEAALGLVFTVYRQVAVPVFLPALAVAVGLALGSQTPATAVTVGVAVVGFVTLAALLGVVLSLATKLATSRSPRLRRYKNYTYVLTFILGFLIWITILQGPLSNQGACDWLQVVPPGWFVDLALFGLTDVPTEPARGLSALGVTVVGFPVLMGTTIALTERVWTADRVSGSVLHRSRSLVGTGLAEWLFAGWVSRPVLTVARKRWLQERRVPIGLLFQGYLLMLAPLVFLPIFAAGEVPGVALVGLVFLSAVGTALAFGAELVGTEYASLPMTLTSVSGRHFIRGTVFAGITISGPFTLLVVLLLGLGSPLVGVELLVLGVVGIVLIACSVVVSAMLGLDAPYYAIRAEAIPFTDITAYTESGGVFKWGKVFAVVGLVCIPAYMVYGARFVGGPVATALGASMPVVRIGALIVTSLFAIAVAALAYRRAVARFNEYTLP TPA_BK010831.1 DAC79926.1 tpg 262647 263981 + ISH8-type transposase ISH30 Loose gnl|BL_ORD_ID|493|hsp_num:0 adeH 45.45 3000779 fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump tetracycline MAAVSYEPPDSVIVDRIKRAFPSDELRERARATNLVQRERKFDTVALFYTLSLGFAAGSDRSIQTFLERFVEMADCDELAYPTFHGWFSPAFVALLREILDDAIENLEPGQTDLSGRLERFRDVLIVDASIVSLYQDATDVYAATGEDQAGVKLHLTESLSTGLPTRFQTTDAKTQERSQLPTGEWVAGALVLLDLGFYDFWLFDRIDQNDGWFVSRVKDDANFEIVEELRTWRGNSIPLEGESLQDVLDDLQRQEIDARITLSFDRKRGSGVSTTRTFRLVGVLNEDSGEYHLYVTNLARDNYHAPDIAQLYRARWEIELLFKELKSRFGLDEINTTDPYIIEALIIVAALSLLMSRVIVDELRKLDAKRQGSDDDAAASSTRLPRRRCSHALERHAHLVQLYLMVDLGYELPDLDELLLWSSRDPNPHRPRLREQVESGEFW TPA_BK010831.1 DAC79927.1 tpg 265099 265326 + uncharacterized protein Loose gnl|BL_ORD_ID|1393|hsp_num:0 CMY-45 52.63 3002056 cephamycin antibiotic inactivation CMY beta-lactamase MTTSLRQTVRVYGSLLVLVIGFLCGGLTIALFISASWVVETLGLVGFVLYVLTTFLCALLSFMFDLIGNAKEAFA TPA_BK010831.1 DAC79928.1 tpg 265451 266725 - ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|3754|hsp_num:0 OXA-491 53.85 3005725 penam antibiotic inactivation OXA beta-lactamase oxacillin MRRLTTLFPSKFLEEHAEELGVVEREGKLQIPVLVWALVFGFAAGESRTLAGFRRCYNSTADETISPGGFYHRLTPTLAEYLRDLVEHGLDEVAVPDTVDADIDRFRDVMIADGTVLRLHEFLSDEFQARHEEQAGAKLHLLHNATDETIERIDVTDEKTHDSTLFKTGSWLQERLVLFDRAYFKYRRFALIDENDGYFVSRLKENANPLITEELREWRGRAIPLEGKQIHDVVDDISRKYIDVEVEAEFKRGQYEGTRSLDTKRFRVVGVRDSDADDYHLYITNLPRDEFFPEDLATLYRCRWEVETLFRELKTQYELDEFNTSDPDVVKILLYAALLSLLVSRELLDLVTEQADDEIVFPPERWAATFRSHAQLILQELGEYLGYSPPPLLERLIEDAQKIHQQRPILQETLATATQPRCES TPA_BK010831.1 DAC79932.1 tpg 268737 269612 - ParA domain protein Loose gnl|BL_ORD_ID|2798|hsp_num:0 ROB-2 25.58 3005079 cephalosporin; penam antibiotic inactivation ROB beta-lactamase MLAYSTYSEAGGVGKTTTAANLAVAHARAGLKPLVVPLDPQDGDLSRLFGVDTDRTESVDNIVRHMIRRPSGEFDDLVRTVEGVDIIPEHNMLSDLAEYLQREKDQAEAMGEAFGMHAQLLRVLQEAGVPDEYDVLICDPPATEGPHLYNAIHATRSLVIPVEPSAKGRAAVEGLESLVAGLEEQLDVEVGVLAAVPVGFKNTRDQRTILDEIDYPIPEVIGERASLMEGCWMRQCSAFEYVRNHRDRQRDYEIETLAQFDRIARHLEEQVGLEAPNPPEPGDLDHEVLSA TPA_BK010831.1 DAC79933.1 tpg 270141 270422 - uncharacterized protein Loose gnl|BL_ORD_ID|227|hsp_num:0 APH(9)-Ia 32.35 3002662 aminoglycoside antibiotic antibiotic inactivation APH(9) spectinomycin MDWVSLLVSGLFAFAWLITFYQSRAENWTVGRTVGWLVFLGGATIGAFYDEFLSAESGLLSWSEPIAAVIMFIGVGIAWLWTPSEDNQSTEQR TPA_BK010831.1 DAC79934.1 tpg 270646 271986 + uncharacterized protein Loose gnl|BL_ORD_ID|4805|hsp_num:0 MCR-5.4 22.95 3007281 peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase colistin A; colistin B MHATIDVRLTVSIDDDKTIPLATLAEFITDQNVESVLLEGLVESLDAARVEALCGEKHAHGNGDQRFQRAGTDTRTAVTTAGEHEFDLHYVEDTAADHDESSYFRPVEDVLSFDGQNRYQQDIAAKSVDLATSLSYRDAADHGDGILSKMPSPTTINRRAREYGSKLKQFLPDCVADTDADAVIPDGTKCHSQDDDRTYHSVQATLGEDTAEESRSLLDLSVNADWDETAADLDDIDAVTDDATVVSDADDGIVTAFTDEYSDHQLDLVHVGRTLDYNLWDDGVFSLDRRNEIVSEVIDEVFHLKNSVAKHRPNEEFAAIRERIARTTERIEKTAWQLDQYGSEKAAGYLRRWLPSIVTFAEQAAEGFEVPWTSNPVERLMGEVSKRCKNQWMRWTTEGLEAILQLRLVKYADPEYYQSFLDELLQRSTKTAMSCDLSVESTRGKL TPA_BK010831.1 DAC79936.1 tpg 276748 278022 + ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|3754|hsp_num:0 OXA-491 43.75 3005725 penam antibiotic inactivation OXA beta-lactamase oxacillin MRRLTTLFPSEFLEEHAEELGVVERNRTLQIPVLVWALVFGFAAGESRTLAGFRRSYNATADEPISPGGFYQRLTPSLATYLRDLVERGLDEVAVPNAVDADIDRFRDVMIADGTVLRLHEFLSEVYEGRHEEQAGARLHLLHNATEQMIERIDVTDETAHDSTLFKTGSWLHGRLILLDLAYFKYRRFALIDENDGFFVSRLKQNANPVITAELREWRGRAIPLEGKQIQDVVDDLSRQYIDVEVEAEFKRGQYEGTRSLDTKRFRVVGVRNEDADDYHLYITNLPRDEFLPSDLATLYRCRWEVETLFRELKTQYELDEFDTRNPAVVEILLYAALLSLLVSRELLDLVTEQADDEIVFPPERWAATFRSHAQLILHELGEYLGYSPPPLLERLIDDAQKIHQQRPILQETLATATQPRCEG TPA_BK010831.1 DAC79937.1 tpg 278559 279104 + uncharacterized protein Loose gnl|BL_ORD_ID|2686|hsp_num:0 mphJ 23.66 3004544 macrolide antibiotic antibiotic inactivation macrolide phosphotransferase (MPH) erythromycin; telithromycin; tylosin MDHPSVELKLPLDGGTHRVEIPQETTLFFWGAVAPGTTDRLIPEEGDAVGSQHRVVQELSNYVSWRISLPDESKPLLDERYRKQGYNGRAWWIARGPVSLPATAEIEFSISGAPPTIGGDPIVLWTEQGETIPWGSTIESTVELVPSAKPAPQFQTRQEQLWNRHTVYVPSWIPVKDQSDT TPA_BK010831.1 DAC79938.1 tpg 279159 279653 - uncharacterized protein Loose gnl|BL_ORD_ID|762|hsp_num:0 tet(X) 28.38 3000205 glycylcycline; tetracycline antibiotic antibiotic inactivation tetracycline inactivation enzyme tigecycline; tetracycline; doxycycline; minocycline; chlortetracycline; demeclocycline; oxytetracycline MTDYPRAKIKFLEWLQGQGEHRGYSPKVNYGEKAILERPRLLARTRASVDQRRHLKFKVNDEVEYENDEFEKVYSIILDLHDGRDWDAEQDTFYPLSLRLINNLANKDINEDHPVTIDLSHPGVERQKNRLQTLFPIEEEDQEPPAERITDDRIKGLNNIAKNL TPA_BK010831.1 DAC79939.1 tpg 280203 280364 - small CPxCG-related zinc finger protein Loose gnl|BL_ORD_ID|466|hsp_num:0 rosB 40.91 3003049 peptide antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump polymyxin B; polymyxin B1; polymyxin B2; polymyxin B3; polymyxin B4 MALKNVACPECGYMVPFTIPSGAEITEVGASWGSTVEEECGNCGESVDIKYSN TPA_BK010831.1 DAC79940.1 tpg 280676 281851 - Fido domain protein Loose gnl|BL_ORD_ID|4163|hsp_num:0 PAU-1 41.94 3006964 carbapenem; cephalosporin antibiotic inactivation PAU beta-lactamase MQPAKLDADAPGNLISYGRESYYKPDPLPPSQDLALDDDFYETLADATFWLGKLSGVSLELDFPPVLYTSLLRKEAMESAEIEGADVDYDALYSLETRTFDEGRDEPSETTAAAETKDTREVLNYETAVKEGIDALDAGEELNVELLHDLHETLLTGVPDDRVDTDTIGDYKTNPNYLGDFLPPAPGAVEDLMDGLFTYYRTGGSYHPLVDIALFHYQFETIHPYGDGNGRLGRLLITLQLYDADLLERPNLYLSEYLNRNKTTYVERMEGVRFHGEWEAWLSFFIEGIARQAHESVERTRALADLRREYEHEYGGKAYTKNQLAVTLFEQPYITSKTVQRLFDIEQSTASRAINELVNEGILEEVPRHGRNKEYRAREIFEILEQPPQTY TPA_BK010831.1 DAC79943.1 tpg 283529 284968 - beta-lactamase domain protein Loose gnl|BL_ORD_ID|3510|hsp_num:0 EAM-1 34.94 3006873 carbapenem antibiotic inactivation EAM beta-lactamase MSLRRLLAVFAVVGMVVIAGCAGGIDNGEPATSGVTEQATTTVATTETAAPTGELVVHQLNVGQGSSTLVVGPDGETLLIDTGDWTDDGEDVIAYLESQGVTRIDHLVTSHPDADHIGGHAAVIEHFETNGDGVGAVYDPGIASSSATYEEYLDAVEAHNVPLYRTQAGDSIPMSGATAQILAPPEGYLANEDRNENSIVVHVQFGASSFLLPGDGETASEEYLVDTYGDRLNSTVLVVGHHGSRSSTSAAFLEAVSPRVAVISSAYESQYGHPHEAVLERLAARSIPTYWTATHGTITFTSNGSAVTVATQQDAPTTATELRSGDPVEPGTGGGLVDRLVIPTAGSGTTPITDPDGTTEPAETTSTSTAGRLDLVEIHADAAGDDAENLNGEYITVEHTGASSLDLSGWTLADAAGHSYTIPEGTVLEPGDQLTIYTGSGTDTATELYWGQSSPVWNNGGDTISLRDATGTTVIEETY TPA_BK010831.1 DAC79944.1 tpg 285367 285849 - uncharacterized protein Loose gnl|BL_ORD_ID|1218|hsp_num:0 tet(Q) 38.71 3000191 tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein tetracycline; doxycycline; minocycline; chlortetracycline; demeclocycline; oxytetracycline MRDSPDQAETHTLRGATDRPALLTIRDVVEEMEPLATAELDDYLHPSVLEVELDDGLCGADEARIDIQWTTRDDYKFHYTDVEGVNLRWGKHPHAGDYIHVSGLEHYHPPPNASSDPDEVEASCIAQSREELVTRAVLKLWRVAYHTDSYEPLNTGRNPP TPA_BK010831.1 DAC79945.1 tpg 285853 286443 - HTH domain protein Loose gnl|BL_ORD_ID|100|hsp_num:0 LRA-9 55.56 3002488 cephalosporin; penam antibiotic inactivation subclass B3 LRA beta-lactamase MNDRNPPEEFADVNEAVGEEWEAETTPYERIRHVVAHTYSPVSADAVADDARTAPKTARKHLNTLADEGFVETTPGEQGGTLYRRSPESLVVEQAADILEHVSTDELVTRIQEMREQLTEYRSEFGVDSPEELAVNQTNQALSETGSPQDEIDPETIREWKTLRRNLAFANAALSIGNAEQFVDSDRRSTDDSVPA TPA_BK010831.1 DAC79946.1 tpg 286872 287111 + uncharacterized protein Loose gnl|BL_ORD_ID|2426|hsp_num:0 LAP-2 36.36 3004826 cephalosporin; penam; penem antibiotic inactivation LAP beta-lactamase cefepime; cefuroxime; amoxicillin; piperacillin; benzylpenicillin; cefalotin; ticarcillin MTGLDSVAFDIETTGFAVDDQLTVVGFDADIGSRIFLNTDGRAPPSNLEARVNDELASSVSISVQQTERTLLSEMDAFV TPA_BK010831.1 DAC79948.1 tpg 287504 288844 + IS1341-type transposase ISH40 Loose gnl|BL_ORD_ID|2241|hsp_num:0 vgbC 40.0 3003990 streptogramin antibiotic; streptogramin B antibiotic antibiotic inactivation streptogramin vgb lyase pristinamycin IA; quinupristin; pristinamycin IB; virginiamycin S2; pristinamycin IC; vernamycin C; patricin A; patricin B; ostreogrycin B3 MKRTNTFAVRPLSETGEQLLRDLLDASAALWNEVNYQRLMRYNDEDGFEGGIWDADTGRLEGRYKGVLGASTAQQVIRKNSEAWRSFSHLKDQYHDESNTSVTEHPNPPGFRGNEDDGRQLRTVIRNDAYTTEWGDRSRLEILVGSELKDRYDHTGRLRLEIAGNPNWPDYEKQGRLELWYDETESTFRASQPVTVPDSARATPLADETAALDIGANNLVACTTTTGEQYLYEGRELFQRFRETTREIARLQSKLPEGRYSSERIRRLYRKRTRRRDHAQEALCRDLLDRLYAEGVDTVYIGGLTDVLDTHWSVKTNAKTHNFWAFKKFTERLACTAEEYGISVEVRSEAWTSQECPRCGSTDRTTRHQDTLTCPCGFQGHADLTASETFLERHTKQAVRPMARPVRFQWDDHTWSESPRSQESPKEQRTDPSTVHHGNVALRESA TPA_BK010831.1 DAC79950.1 tpg 291390 292622 - orc / cell division control protein 6 Loose gnl|BL_ORD_ID|1488|hsp_num:0 vgaE 34.88 3002833 lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; pleuromutilin antibiotic antibiotic target protection vga-type ABC-F protein clindamycin; virginiamycin M1; tiamulin MTPDSSPSSVDDPLFESGHRIFANKDLLKIGHVPEADRIVGRDEEISKLAKRLNGAVHGYSPENVMIYGKTGTGKSLVSKHVCQRAQNAAQDGVEIGTAYIDCAEDNTETQAISSLAAKLNDESSTGISVPHTGLSTSKYYKLLWKTLDAQFDSVIIILDEIDLMNDDSVLMKLSRAEEAGKIDCSVGVIAISNKIQYVDNVNERVKSSFQHKELFFKPYDANQLREIMFNREDAFQDGVLSEDVIPLSAAFAAQEHGDARKAIDILRHAGEVAYEAGAELVTEEHVRQAQQHAEKDRFRELVNGAPTQAKAALLALTELSVNSNDDAFLTSRVYDQYEHICNHLDMDILSVRRFRDILKEQAFLGVVEIEKINKGSAGGIHLQNRLIEDSQVVRETILEDSRMQDWTRE TPA_BK010831.1 DAC79951.1 tpg 293341 293988 - uncharacterized protein Loose gnl|BL_ORD_ID|2709|hsp_num:0 ICR-Mo 23.75 3004569 peptide antibiotic antibiotic target alteration intrinsic colistin resistant phosphoethanolamine transferase colistin A; colistin B MPIEVECDFCGETISRPPSVVERAEHHFCDKTCQGNWRSEQKDNRVVLQCDYCGTDFKRYEWNLKDDQTNQFCSNECRGRWQIENRPQTECTNCGETIGRIQYDIESADRHFCSRDCQWEWQQETATYDWESTPNYGPLWKERREQVLERDNRTCQGCGRSENELGYTPRVHHIRPFAEFDEDEVEAAHDPSNLVSLCEPCHTRWEGVPLRPKLL TPA_BK010831.1 DAC79953.1 tpg 295993 296916 + ArsR family transcription regulator Loose gnl|BL_ORD_ID|2330|hsp_num:0 MexR 26.15 3000506 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole MLRRIELEVLATVDRGDTISELATKLNHSESYLSRAVADLVEKGLVYTERDGRRKRVVPSDARAVELYRDLVRQHSHIDFPELLTGKALEVLYYLDQPRTVSEIADRSDNYRNTVNRVLKRFRDRGLVGTADGHYEFNADFDRLHEFARELAHHLHRQRLEAVAPKGTILWEDYDEFLAQAETEIDAEAFHETGLARFAAFDLQFLLTGHRYYVYSKDLDAVSPAELCCHTLVIDGGSRYRSYCLLLLSHVDVDEADLREQAAKYGLEDEIDVLLCYLETHGEVVDERLPEWDEFQKLAVEYEVRLS TPA_BK010831.1 DAC79954.1 tpg 296908 297333 - spurious ORF Loose gnl|BL_ORD_ID|4663|hsp_num:0 vanH gene in vanA cluster 30.0 3002942 glycopeptide antibiotic antibiotic target alteration vanH; glycopeptide resistance gene cluster vancomycin; teicoplanin MDPTMPRFPCSRASMMERSRKLSSSTTYSRKRSTASRPTPATTQPSTSSIAWKKTPASTSTHSPPTPSRQGRPSSANRNRSPSSTPALSRICKPRGSAIYMRLTTILTLSRMSIDSIQQRIPMTQTDAGWHHGWRRRSVSG TPA_BK010831.1 DAC79955.1 tpg 296954 297388 - homolog to endonuclease VapC Loose gnl|BL_ORD_ID|3853|hsp_num:0 OXA-603 22.64 3005824 penam antibiotic inactivation OXA beta-lactamase; OXA-61-like beta-lactamase oxacillin MPRALIDTTVLFAAAYRRDGSHDAALPVLQGIDDGTLPEAVVLDYVLAETLDGLTTHAGHDAAVDLLDRMEENARFHIDSLTTNAIATGKALFRQQEPLSFVDACIVAYMQTEGLGYLYAFDDDFDAVEDVYRLDTATNPYDPN TPA_BK010831.1 DAC79956.1 tpg 297389 297640 - homolog to antitoxin VapB Loose gnl|BL_ORD_ID|1215|hsp_num:0 mecA 29.17 3000617 penam antibiotic target replacement methicillin resistant PBP2 methicillin MSSDRIDAESKVSGNQANIPSRIRRELDIDDGDQLRWHLEDDGSIRVHVIQQQTGTFADFDGYAGEESTDVTSDHDAWGVDVE TPA_BK010831.1 DAC79957.1 tpg 297803 299167 + homolog to restriction system mrr Loose gnl|BL_ORD_ID|674|hsp_num:0 AAC(6')-IIc 39.22 3002596 aminoglycoside antibiotic antibiotic inactivation AAC(6') dibekacin; sisomicin; netilmicin; tobramycin; 2'-N-ethylnetilmicin; 5-episisomicin; gentamicin MAVLDDLSGFEFEDVMEDVFRTLGYENVRQAEKTADEGRDVIMEEVVDGTRRAIVVECKHTGTVGRPVVQKLHSAIATFDFDGPKRGMVVTTGRFTSPAQEYADRLQQNNDPHPIELLDGEDLREIADEIGLDLYNGRIEILCDETLRPYDPATDLDAPIQEAFHDIENIEAADLPTPHSAVTFRPVVAVTADTNAVFETSVGVIHRINDQTRFVAHAERGQPQVVDENVATLVTENLHATVVLDSEQLGEIFDEVEERRFGQTQTGYKEWTVERLQQHHTTTVTYTGDNNVTYNKTCEPNLSDISVQSIEPVFLPEVRQMTEIQEYTYPYEYYAAGPSRVTAEDGIHQCVYCDTSGVDETYTYCPNCGAIACSTHIKTERLEGEPICTGCAVTERFALKTKYFYDGQNLEAFREEYADMPLHEKTMENKWLAGGSVVATLLLVVGLLVIGGII TPA_BK010831.1 DAC79959.1 tpg 299591 299851 + homolog to phage PhiH1 repressor protein Loose gnl|BL_ORD_ID|982|hsp_num:0 LEN-3 39.13 3002475 penam; penem antibiotic inactivation LEN beta-lactamase MRFDADWMSRADDRILEHLSEDGPDTPKEMADSDRVRFSRQHINARCKTLVEYGLLVHLGNGVYDITREGEQYLAGDLDARDLDPE TPA_BK010831.1 DAC79960.1 tpg 299854 300363 - uncharacterized protein Loose gnl|BL_ORD_ID|2172|hsp_num:0 FPH-1 26.87 3004795 penam antibiotic inactivation FPH beta-lactamase MSRLHIADTGLFVAMGQPSNSRYQAVRRFARRNDVAIVLPERVYEELTVDESDVEAPPVDAAIDEGWATVAAPLEFSEPVVSRVMDGVQRYIANADDRPADEVERADAALAALAAQHLSAGTTTEVYIYTTDIAAGEGAETVLASEGYGDSVTFVNGFRFIEDLVAGDS TPA_BK010831.1 DAC79961.1 tpg 300360 300959 - TrmB family transcription regulator Loose gnl|BL_ORD_ID|2386|hsp_num:0 OXA-267 36.17 3001723 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-213-like beta-lactamase oxacillin MSRTSNRADGDIVQDFLSVADLLEEPQLAQLYAYLAREGEATVQDVMDDLELAQGTAYSYVNRLVDAGVVDVTDDEQPRRYAAREIDLTVTTAAGDREYTITPALIDAVGRRETDADIDTYIDRHGVAGLATALTYAIARERGEVTHRLMAEDLDISPLAAEMILQALRPVVHEHYDIEEAGAGLDELDIDDGDGADDA TPA_BK010831.1 DAC79962.1 tpg 301033 301449 + spurious ORF Loose gnl|BL_ORD_ID|1196|hsp_num:0 tet(44) 25.0 3000556 tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein tetracycline; doxycycline; minocycline; chlortetracycline; demeclocycline; oxytetracycline MLLEITRPVRREPTQATGGAQLQRAFQMPEFHPQPRERCERVDNQPTAVTGDVIALVGIRLRLDRTVDTDRMADPFVLSLGMGLASLGTGRGVEESTSVEFLAGPCRNVRLLPRHLAFSVAPVPTPARNEGYRAKRLV TPA_BK010831.1 DAC79963.1 tpg 301548 303731 - probable iron-sulfur protein (4Fe-4S) Loose gnl|BL_ORD_ID|569|hsp_num:0 DHA-7 37.25 3002136 cephalosporin; cephamycin antibiotic inactivation DHA beta-lactamase MSADTRRQKAERIRHLLDTEGDAVHENTQVFNEGRYESTANLDDYDELKNEARAIKEDAIERLPELIDQVTEAVEANGGSVYVADDAADANRYMEEVVDGRDVVKSKSMTSEEIEVNESLEARGGDVWETDLAEFVLQVADEAPSHIVAPAIHKSREEIATLFNEVFDPEEPLETAEELTRFAREYLGEKILDAEVGMTGANFVTADTGTLALVTSEGNARKCVQATDTHVAVAGVEKLVPSVEDLQPFVELIGRSGTGQDITSYVSLFTPPSDSPTFGGNELESGDDREFHLVLIDNGRMEMREDDQLRETLYCIRCSACANSCANFQHVGGHAFGGETYSGGIATGWEAGVHGEDSAAEFNDLCTGCSRCVNQCPVNIDIPWINTVVRDRINRGKDGDLDFLVEGLTPDEEPGGVDLQKRLFGNFDTLAKLGSAFAPLSNWAARTGPARSLLERTLGVDSRRELPEFERESLVEWFEKRGPRVGRDEARRQVALYPDAYTNYVRTERGKAAVRVLEALDIRVDVPPAGESGRAPLSQGMVSTAQSNANAVYDAIAPAIAAGHDVVVIEPSDLAMFHREYERLLPEDDYAALQEHSYELMEYVYGLLENGADIDVLPGGGDERIAYHSHCQQRTLDLEPYTVAVLEDCGFDVTTSDVECCGMAGSFGYKSEYYELSVDVGETLVDQFTTEDTADRTVVASGTSCLEQLDALLTRRPAHPVRLLDTQ TPA_BK010831.1 DAC79966.1 tpg 306226 306399 - uncharacterized protein Loose gnl|BL_ORD_ID|132|hsp_num:0 adeF 39.13 3000777 fluoroquinolone antibiotic; tetracycline antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump tetracycline MATGVYLALMPLTVGRLATVPDGELADIRPNDRPIATTNSAFEQIPNRENGALTEFV TPA_BK010831.1 DAC79969.1 tpg 307015 307326 - probable VapB/AbrB family antitoxin Loose gnl|BL_ORD_ID|3590|hsp_num:0 GRD33-1 28.57 3006926 carbapenem antibiotic inactivation GRD33 beta-lactamase MSESESEKVVSVSSRGQATIPKEFREELGIDTPGRVKFVRTDEGEVIVRPIQSATDLRGILAGKTDDQGNSAVERLREERKQDKASDEELQERYVGRDTEDTK TPA_BK010831.1 DAC79970.1 tpg 307399 308322 - transcription initiation factor TFB Loose gnl|BL_ORD_ID|2226|hsp_num:0 BahA 27.78 3003984 peptide antibiotic antibiotic inactivation Bah amidohydrolase bacitracin MTTSEPYERAFDEDIQRGTTEPCPECGGPVRTNSAETVCADCGLIIDEQSIDRGPEWHRDDADTAKRTGAPLTPARHDRGLSTVIGSGQDARGTALSSEKRRRLARMRREQSRGRWRSTKERNLGHGLTEIRRIASALGLADSVRDQACQLFRTAQNERLLKGRSIEAMAAASVFGACRCNGESWLIDDVAPMAQVGQNRVENAYTVLNEELGLPTPPVSLDQFVPRLASDLGCTDVVRRRAEELVVQAVDAGITTGVHPSGFAAACLYMAACVHDAPLTQADAAAAAGVTVETIRSHRDRLLSIVE TPA_BK010831.1 DAC79972.1 tpg 308896 309099 - insertion element protein (ISH2) Loose gnl|BL_ORD_ID|2305|hsp_num:0 tetA(46) 28.21 3004032 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MARTKMGVSIRTELVDELDSLVDECSDLGASRSEIVEAILTAYFQNDEDQIKQTRELIIRNRKRSNS TPA_BK010831.1 DAC79973.1 tpg 309345 309755 - spurious ORF Loose gnl|BL_ORD_ID|1474|hsp_num:0 APH(2'')-IIa 31.71 3002635 aminoglycoside antibiotic antibiotic inactivation APH(2'') plazomicin MLGRDRPDRGFDWFSHPNSGLRGRVVGERERFVAAVPLLDEIVFLAGIRRRRRWERFVLEVVEDCERRVVRVGLLLAFDPLDKRLVAGFLEREPVLSSELPEAFVFVLVQFSLHVLGVVAAHRDPSCYSHLLVHEV TPA_BK010831.1 DAC79974.1 tpg 309390 309701 + uncharacterized protein Loose gnl|BL_ORD_ID|2377|hsp_num:0 lnuG 31.03 3004085 lincosamide antibiotic antibiotic inactivation lincosamide nucleotidyltransferase (LNU) lincomycin MSSNDTKHVQTELNEDEYERFREFAREHGLSLKEAGHEALIEWIERQQQADPNDPAFTVLDDLEDESLPASAATDAREEDDLVEEWDGSDESFTLADDPSAQS TPA_BK010831.1 DAC79975.1 tpg 309826 311100 - ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|2194|hsp_num:0 catII from Escherichia coli K-12 39.53 3004656 phenicol antibiotic antibiotic inactivation chloramphenicol acetyltransferase (CAT) chloramphenicol MRRLTTLFPSEFLEEHAEELGVVERDRKLQIPAFVWAFVFGFAAGESRTLAGFRRCYNSTADETISPGGFYQRLTPTLAEYLRDLVEHGLDEVAVPNAVDADIDRFRDVMIADGTVLRLHEFLSDQFEARHEEQAGAKLHLLHNATEQTIERLDTANEKTHDSTLFKTGPWLENRLVLFDLAYFKYRRFALIDENDGYFVSRLKQNANPLITRELREWRGRAIPLEGKQLRAVLDDLDRKYIDVEVEVEFKRGPYNGTRSLDTKRFRVVGVRDEDADDYHLYMTNLVRKEFFPADLAQIYRCRWEVELLFRELKTQYNLDEFNTSDEHVVKILLYAALLSLLVSRDLLDLVTEQADDELVFPTERWAATFRSHAQLFLHKLGEYLGYSPPPLLERLTEDAQKIHKQRPILQETLATATQPRCES TPA_BK010831.1 DAC79978.1 tpg 313038 313502 - uncharacterized protein Loose gnl|BL_ORD_ID|4814|hsp_num:0 vanS gene in vanP cluster 48.15 3007192 glycopeptide antibiotic antibiotic target alteration vanS; glycopeptide resistance gene cluster vancomycin; teicoplanin MSDDDRAGEFGPIYLPALQRIRDLWLDLEPLVDATGYDDVVAPTELQISLSDGLGDADAARLDIQWSELEMYSFHYVDSEDVNWRFDRHPNTHSPENHFHPPPEAATSAAEPSCIDVTEVSLVTRAVHAMWRAAYETGDLDRLNSASNPPYGWR TPA_BK010831.1 DAC79979.1 tpg 313499 314011 - HTH domain protein Loose gnl|BL_ORD_ID|4993|hsp_num:0 RSA1-1 25.0 3004444 carbapenem; cephalosporin antibiotic inactivation RSA beta-lactamase MAETGDDVNEQVKADWQDDTTPFERVYEIVEQTHDGQSAAEIADRALVSEPTARRHCKALVNTGFAETEQDGQTTLYKRNSDRVLMSRIRELREEVDRPELLDSIQDMKAEIRRYEDRYNVVSPEELAQQLEAGETDGWDDLTAWRTTRQNLAVAQAALAYDEASHQLAV TPA_BK010831.1 DAC79980.1 tpg 314185 315084 - uncharacterized protein Loose gnl|BL_ORD_ID|2018|hsp_num:0 mexM 32.89 3003704 phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump chloramphenicol; thiamphenicol MSSNNVTTDVVSVDEQAFENAGGQAVDEDGFPVVDETPAFEAEVEQETQAKVDANHPDGIADTSEDRIHGVTLEQEERIRAREAELERISAQAELGTQDGREQRTRAVAAEGSTERRREFQQRAASVEPMADPERDDPRAELSQDELATVNTEADRLATRLDGWSRAAISRRLAEAIVDGRDLTSAVVRVFEELQTAPGGTVPIDALEDIDRKEVSVEGRVTQLWEPSSPSIAQVGLIEDESGRTKLTSWKASDAPWIEEGERVRIHGAAKNWYNGRVSVAVTGWSTLHFPERGRWWDE TPA_BK010831.1 DAC79981.1 tpg 315154 315651 - spurious ORF Loose gnl|BL_ORD_ID|1717|hsp_num:0 LEN-15 26.67 3002478 penam; penem antibiotic inactivation LEN beta-lactamase MSLRVVCLVARQALFCCVRHGSHRSPRSPLRVARDRPFRACGRSPHRPRPFRAKMDVPSTPAGKRGGLRGVAAHPPRFLRWPLAPGGSLEDSLRSSSKPCLAARGSRCSPLASPWPPAGQPRIARQDGARCWIVDLLGRALARAQEGAREGASESAQTVLSVVVR TPA_BK010831.1 DAC79982.1 tpg 316952 317128 - uncharacterized protein Loose gnl|BL_ORD_ID|1754|hsp_num:0 mdtE 28.57 3000795 macrolide antibiotic; fluoroquinolone antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; cloxacillin; oxacillin; norfloxacin MSVELNEIEEAEVELEEWLVEQAENGVPEIVLIGLLRDYADDIEHLGYVPRMWGESDH TPA_BK010831.1 DAC79983.1 tpg 317427 318326 + PhzF family protein Loose gnl|BL_ORD_ID|894|hsp_num:0 RCP-1 41.67 3003563 penam antibiotic inactivation RCP beta-lactamase MSDIRYDIVDVFAQSQYTGNQLAVVQPEGELSGEEMQRIANEFDYSETTFIDPDGSHADGFEVRIFSPTTELPFAGHPTLGTAYVLRERLGLSDDELVLHEQVGAIPVSVEKTATGDEILLMEHPEPTFDEIIEPARAADAVSLPADVLDDQFPAQIISTGVPTLIVPVESLSAVKEAETNDEVYSELVDQYGVRNLLVFAPETYEPENELNVRVFAEFFGIPEDPATGASNGCLAAYLTEHQYFDTSEIDVRVEQGYEVNRPSLLYLRGQTTADSIQVEVGGRVIPTATGTLVESNSL TPA_BK010831.1 DAC79984.1 tpg 318817 319146 - uncharacterized protein Loose gnl|BL_ORD_ID|1770|hsp_num:0 marA 38.1 3000263 fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; glycylcycline; cephamycin; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; penem; disinfecting agents and antiseptics antibiotic efflux; reduced permeability to antibiotic resistance-nodulation-cell division (RND) antibiotic efflux pump; General Bacterial Porin with reduced permeability to beta-lactams tigecycline; tetracycline; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan MTVDEAFYDVRERTENPAHASVEDVCELVRKRAQDPRDDHMNSHFDEAMADIVERHGIETVQTVIRRILVEHYPFRTATVDLEMRNVDGVWIGTAATGYLRELNSEQDS TPA_BK010831.1 DAC79985.1 tpg 319015 319578 + spurious ORF Loose gnl|BL_ORD_ID|2405|hsp_num:0 OprZ 41.67 3004142 macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; cefepime MRIHVIVTGILGSLANEFTDVFDGRVGGILGSLPYVVERLINSHESGLSSKVASVEAFDVFGSRRRWRRTSASTSSSIVIRSMPFASLTISSMSDARLAACSSPSVLSMAWIRIERFSCQPQFQQFCEQAIWSSSSAAITASTSDIESGRSGPTSIVMSDPHSGHCMVFQNTARAVKIWFSERKSET TPA_BK010831.1 DAC79987.1 tpg 319575 319817 - uncharacterized protein Loose gnl|BL_ORD_ID|1219|hsp_num:0 tet(32) 30.43 3000196 tetracycline antibiotic antibiotic target protection tetracycline-resistant ribosomal protection protein tetracycline; doxycycline; minocycline; chlortetracycline; demeclocycline; oxytetracycline MLDSEEFEENQRGNTEQRRTMIKQWAEYIRTHGDEEWSRQQNKLINSQLQSVNDLAETGDTDPVQFANVRDRLQDPESGT TPA_BK010831.1 DAC79988.1 tpg 319865 320476 - HTH domain protein Loose gnl|BL_ORD_ID|3066|hsp_num:0 KPC-36 39.02 3005368 monobactam; carbapenem; cephalosporin; penam antibiotic inactivation KPC beta-lactamase MSERTDTPAPADAHADTVFDVGSADAYEKQRRVHRFLSQETRNHIIQVLLGHPSHLASITELDYFIPKSRSTIREQLDNLADRNIVSKYHHEPNEGERGLPTDFWGPTEFGVELLYEYKYLRGVPIMRSLHDHTALTEQVERHLNAARPDLPEAVTDALEFDEIDVTESESAEDRRAALQEGSLFTDETPKEERSESPIDDLF TPA_BK010831.1 DAC79989.1 tpg 320591 321430 + uncharacterized protein Loose gnl|BL_ORD_ID|3223|hsp_num:0 ADC-231 35.29 3006400 cephalosporin antibiotic inactivation ADC beta-lactamases pending classification for carbapenemase activity MTEETRKDRWRRVKAAVDRALHGVAVPRPDRSEVARFINEAVPAFTQAGITTYLVFGSYRGDYEVRLRAMAYELSKPIDAEATLIGDTADPDTRVVPSFLIKFHALAEFADHLVGVYEKESGGESPELGLLDQRPYFEKGWMFPRDYTGLTRDALESKADVIDAAIQIYYAPDADDETKRRELKALVSEAQTFDIDITEQEVVDALRDRDRDALGEIASYSWVHLNLFRKYELHDRCFPWFSEQELRTLATEVPGPARPQWEEEFESTDLGNTESDESD TPA_BK010831.1 DAC79990.1 tpg 320684 321673 - spurious ORF Loose gnl|BL_ORD_ID|634|hsp_num:0 APH(3')-Vc 39.39 3002651 aminoglycoside antibiotic antibiotic inactivation APH(3') neomycin; ribostamycin; paromomycin MHPALRGNSIRLSRSRKGSVQHGLDIPFGLLVADLNLLPGFLGTTVRFDASFVEPSSILTHGIQFHLRCPEIRVCGHFRRRLVRLIRLCVSKVCGFEFLFPLRTGRPRHFRRESPKFLLRKPGETAVVEFVFPKQIQVDPTVGCDFSESIPVTVAKRINDLLFGDIDIKGLRFTDECFQLSSFRLIVSVWCIVYLNGSVDHVRLRLKGISRQARIIPGEHPTFLEVGTLIEQPQFGAFTATLLLVDANEVVRELGERVKLDEERRHDTRVWISGVTDECGFSVDGFAEFVRHRSEPNLVVAAITAEHKIGRDARLGERGHSLVDEPGNL TPA_BK010831.1 DAC79991.1 tpg 321729 322067 - uncharacterized protein Loose gnl|BL_ORD_ID|597|hsp_num:0 AAC(3)-VIIa 40.0 3002541 aminoglycoside antibiotic antibiotic inactivation AAC(3) paromomycin MQQTLVGCAFCDAPPGTETGEAHTWGQDERVTHPICVDCAIQERPDSNDLDHHAYDGCGRIVDTLPALTSFHVELGHLDGTVHLCVRCSPGGPATYWTRDLEEHLVADINSE TPA_BK010831.1 DAC79992.1 tpg 322067 322357 - uncharacterized protein Loose gnl|BL_ORD_ID|3411|hsp_num:0 CSA-2 32.61 3006870 cephalosporin antibiotic inactivation CSA beta-lactamase MPGLDPHDDTSRDYEQFEKEQLALDRDATSVDTADVDDRTAQRLVSDLVDADVVTPVPEDQVLVHEPSGTTFDSSTQLAVFHRGWTAGRDADTEGE TPA_BK010831.1 DAC79993.1 tpg 322488 323033 - uncharacterized protein Loose gnl|BL_ORD_ID|728|hsp_num:0 iri 28.21 3002884 rifamycin antibiotic antibiotic inactivation rifampin monooxygenase rifampin; rifaximin; rifabutin; rifapentine MVVVEEVTKLSERRTQTSSEVFPDDSLASIREAVEAVPASVFDGSTKHTEVGGFDAAIADRLSQYEYEGDAAGGFNPNCKLWSHQGFNYSVDLYDADARIAIEVEKSERKNVSDDLLKFQKGYRTKKDGRPKIEFGCLVVPVNYLGRHNLYQHSLTKLDFMKGVLFIDDVAVIGYRDPRPD TPA_BK010831.1 DAC79994.1 tpg 323341 324333 - ISH11-type transposase ISH11 Loose gnl|BL_ORD_ID|4561|hsp_num:0 RAHN-2 35.29 3006980 cephalosporin antibiotic inactivation RAHN beta-lactamase MSPATLQDDPSVDSFFNVVETETLALFEHLSFEFLEEFDVFAPAETGRTRDHEPPELMRGFLHCYYKDIYGIRPVERELRNTVVWLSCGFDRPPSRDAVDRFLTDLEHVVNKVFDHLVEQAALRGLLDLTYCIDSTDVRAMPADQDASKCYDPTDDEYYHGYGCTIVSTGQKIPIAAEFTESKQAPEETAMRVTRDALAVAKPIWMVGDSAYDTLDWHDHLLAAGVVPVAPYNARNTDDPKDIEYRVEDRIEQHSEDVQLKQSTLDETYNRRTGVERTNESVKDCGLGRTHARGRVHARAQVFLALCLRLVVAITNYERGDNPGSPIITV TPA_BK010831.1 DAC79995.1 tpg 324913 325254 + HTH domain protein Loose gnl|BL_ORD_ID|899|hsp_num:0 lmrC 34.69 3002881 lincosamide antibiotic antibiotic target protection Miscellaneous ABC-F subfamily ATP-binding cassette ribosomal protection proteins lincomycin; clindamycin; celesticetin MDDPRDDTPYVVIPDTDEYYALGFLVPNRGEQFTPSEIAASTDMSEADAADTMTTLFEDDLVERSQGTYYVPVDRAEELQRRLESVDAAAKVHENAPDDAYAVEGWEEEVDSL TPA_BK010831.1 DAC79996.1 tpg 325010 325516 - spurious ORF Loose gnl|BL_ORD_ID|2408|hsp_num:0 AxyY 48.28 3004144 macrolide antibiotic; fluoroquinolone antibiotic; aminoglycoside antibiotic; cephalosporin antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; cefepime MGFGGLQPHIGQPPGVPDEGISTQDVPVLKSANPIGSETPRWQAPKTRPKPPVTHYSFLEDTPSSKYHLPPPHTVFEVSSPTNWTVSTITNLPPPPSLRQHRHHRAHSHVPLRRRRPTQAAVEVLPRDLPGRNRFPETVRRGRLRRGWSSCLLRPLHSCRCWRQSQTA TPA_BK010831.1 DAC79997.1 tpg 325607 326050 - spurious ORF Loose gnl|BL_ORD_ID|2093|hsp_num:0 FAR-1 28.81 3004784 penam antibiotic inactivation FAR beta-lactamase MSSIDSFCIDNYYQSIVTSAVSLSGCSKSIRSEPTPRCCSNTILDRGGAHSRYVAISELPHAEQRSTSPDSRVVPQRRHSTIKSVSAPPNRRVSRRIMRSDRQRRRSPGIPPSTVRRRRSRTRRGHAGGGSSRHIGDRCRLGDSARA TPA_BK010831.1 DAC79998.1 tpg 325609 325761 + small CPxCG-related zinc finger protein Loose gnl|BL_ORD_ID|2711|hsp_num:0 Acinetobacter baumannii AbaF 45.45 3004573 phosphonic acid antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump fosfomycin MPSQNPRVGICPRCGDSIRHRHVLVEYETDDDARYWAECPGCGGVVDPNA TPA_BK010831.1 DAC79999.1 tpg 325758 325904 + small CPxCG-related zinc finger protein Loose gnl|BL_ORD_ID|23|hsp_num:0 OXA-45 29.41 3001794 penam antibiotic inactivation OXA beta-lactamase oxacillin MIRRLTRLFGGAETDLIVECRRCGTTLESGDVERCSACGSSEIATYRL TPA_BK010831.1 DAC80000.1 tpg 326025 326300 + uncharacterized protein Loose gnl|BL_ORD_ID|2160|hsp_num:0 apmA 43.33 3003918 aminoglycoside antibiotic antibiotic inactivation AAC(2') apramycin MQNESIEDIPQPASDSYSAGGRVQIYTGSDDPDSRYHGVVCVIVDVLTDGLGTETRRATDGYSYILQDVETDEELLISFRHQDLVPVKSAQ TPA_BK010831.1 DAC80002.1 tpg 326967 327602 + ISH14-type transposase ISH29 Loose gnl|BL_ORD_ID|255|hsp_num:0 smeD 26.79 3003055 macrolide antibiotic; fluoroquinolone antibiotic; tetracycline antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump tetracycline; chloramphenicol MPENDRLSGCLDQIDLEFVEREATPQLLMKLSIQLHLAGLSLSNTVSILEIFGVERARSTVHNWVHKADLQPESGRSPDHVAVDETVIRLNNEQYWLYAAVNPETNELLHTKLEPTRTNVIARSFFAKLREKHDVDTAVFLVDGAPTLKDACQRHGLRFQYEKHGNRNTVERVFREIKRRTSSFSNCFSNAAADTADDWLRSFSFAWNQLI TPA_BK010831.1 DAC80003.1 tpg 327699 327929 - uncharacterized protein Loose gnl|BL_ORD_ID|2694|hsp_num:0 erm(32) 38.1 3004592 macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase narbomycin; methymycin; pikromycin MTHLFSREVPVFSVVVGSGDLVSSVYRTWDTPIFLSDGERTDVENQQPTRSSAVSRRSVRPQGTSGSDTESEGRRE TPA_BK010831.1 DAC80006.1 tpg 328989 329141 + small CPxCG-related zinc finger protein Loose gnl|BL_ORD_ID|2350|hsp_num:0 MexF 40.62 3000804 fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump ciprofloxacin; trimethoprim; chloramphenicol; norfloxacin MPTDDSSLGQCSECGDRIAAAWLLVEYSKDDGTDGVWAECPACEAVVAPE TPA_BK010831.1 DAC80008.1 tpg 329788 330348 + TATA-binding transcription initiation factor Loose gnl|BL_ORD_ID|3616|hsp_num:0 IMP-64 47.37 3005471 carbapenem; cephalosporin; cephamycin; penam; penem antibiotic inactivation IMP beta-lactamase MSSLADTIHIENVVASSDLGQELALDQLATDLDGAEYNPEDFPGVVYRLQEPKSATLIFRSGKVVCTGAKSVDAVHDALEIVFDDLRELGIDVDSTPPVKVQNIVSSASLEQSLNLNAIAIGLGLEQIEYEPEQFPGLVYRLDDPDVVVLLFGSGKLVITGAAESADAQHALAHVNDRLTELGLLE TPA_BK010831.1 DAC80009.1 tpg 330770 331546 - uncharacterized protein Loose gnl|BL_ORD_ID|2188|hsp_num:0 hp1181 32.08 3003964 fluoroquinolone antibiotic; tetracycline antibiotic; nitroimidazole antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump ciprofloxacin; tetracycline; metronidazole MPLPTPQSLARTYRTPGYEDPWECVADYQRVLEYTTEHPSLGSSAVSTRINLPRSRIRPWMNDSRPDVVRGIQTAEANGWLAEHATHETTTALVALAAWALSGGSINHGEGGSHVYFSLDHDDDDYFDTLASTAGFEYHVVNETASERATEARPAADGSVLARVLIAMGVPNTATEKHDATSLPAFVGTLSEGLRLAFARVYVLNRGAKHPDKDTLTVRVGRPAAYLDDLVEVLRAVSGEAVTRTGKTVTVSAAAARV TPA_BK010831.1 DAC80010.1 tpg 331729 332220 + DUF1628 domain protein Loose gnl|BL_ORD_ID|2192|hsp_num:0 lfrA 35.87 3003967 fluoroquinolone antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump ciprofloxacin; norfloxacin MKKVTLEIPDRDERGVSPVIGVILMVAITVILAAVIASFVLGFGGSVNETVQAGADVSENGDGTATVTWISEGTASELEVSVEGVDGNVTLDQVGDSATIQYNSDTDSDNKIDDDDNTITATDDGDGNDPGEVTLQVTVTGIGSEDTRTVIAQEEVTLENQNN TPA_BK010831.1 DAC80011.1 tpg 332801 334225 - ISH10-type transposase ISH10 Loose gnl|BL_ORD_ID|2673|hsp_num:0 MCR-7.1 30.3 3004517 peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase colistin A; colistin B MVIVDRDDLSKDELLSRFLQMEERIDELEEKLEQKDERIEELETRLRKYENPHTPPSKRRSGTDESPTSQDDEDDDVRTDGGTPGRKDGHDPEWRSTTDPDEEIEVTCDCCPECGDHFDESVGVSPRLVEEIPDPQPPEITRYNRHYYQCDSCGTETVAAHPDCPDEGQFGVNVIAQSALSRYDHRLPYRKIADRFEQLHELELSGASAWHATERAARAGRCEYEQIRREIQDADVVHIDETGIKRDGEQAWIWTFKTAQHTLYAVRESRGSDVPAEVLGEDFAGTVICDGWTAYPAFSSNLQRCWAHILREAEDAAEKQAEGEPIYHALRQVYVALQARLESDPSPRERADLQRVARRELESLIERSVPDGPVATLLGKIEGGLDHWLTFVGEPAVSPTNNAAENALREPVVLRKIIGTLRNDRGMFVHETVLSLLATWRQQGRNPYEELRRVVSSNEMLSRAHAVPAVETSG TPA_BK010831.1 DAC80012.1 tpg 334620 335177 - uncharacterized protein Loose gnl|BL_ORD_ID|1876|hsp_num:0 TEM-60 25.27 3000929 monobactam; cephalosporin; penam; penem antibiotic inactivation TEM beta-lactamase ceftazidime; ampicillin MYTANIADTVMFRNLGKHPSPHLQSLKSAVEEAGTEVWVPAAVYHELADTGSADSPTNPYLDTAIEEGWLRVATPLPGDRTAGFESSAGPVEKARFVADEFLNQQSKYPETNNWQDAAVVALAVRLFDANARIRVITHTADENLAKACARIPPEFGYYDIKSRYYNPPQTAKVEFPTVGQLTWSE TPA_BK010831.1 DAC80013.1 tpg 335189 335842 - TrmB family transcription regulator Loose gnl|BL_ORD_ID|4986|hsp_num:0 PSZ-1 25.0 3007648 cephalosporin; cephamycin; penam antibiotic inactivation PSZ beta-lactamase cefoxitin; cefazolin; amoxicillin; benzylpenicillin; ampicillin; cefalotin MVSSFVTLHKMSYDTEHVRNAGDTPGTITGIPTFAELLENPSLADLYTSIRQAETATGPELVETTTVSKKTVYDYLHKLEQAGLISKVGDETGTAVYTAQEFELTLTVRETEVSITPKIIEVIAQKNEYPAIERVLEDYGIVTFALAYDLVNAHSEGEVTIRQIASLTDLSPGTTYDLVEALYSVLDLGDDDSTPTTYTPDEFDAEGGDLLEEYADK TPA_BK010831.1 DAC80014.1 tpg 336128 337210 + isopentenyl-diphosphate delta-isomerase%2C typeII Loose gnl|BL_ORD_ID|3890|hsp_num:0 OXA-640 25.37 3005861 penam antibiotic inactivation OXA beta-lactamase; OXA-184-like beta-lactamase oxacillin MTAQDSTQTEDRKDDHLQIVQERDVETTGTGFDDVHLVHNALPELDYDAIDPSIDFLGHDLSAPIFIESMTGGHHNTTEINRALARAASETGIAMGLGSQRAGLELDDERVLESYTVVRDAAPDAFIYGNLGAAQLREYDIEMVEQAVEMIDADALAVHLNFLQEATQPEGDVDGRNCVAAIERVSEALSVPIIVKETGNGISGETARELTAAGVDALDVAGKGGTTWSGIEAYRAAAANAPRQKQIGTLFREWGIPTAASTIECVAEHDCVIASGGVRTGLDVAKAIALGARAGGLAKPFLKPATDGPDAVIERVGDLIAELRTAMFVTGSGSIDELQQVEYVLHGKTREYVEQRTSSE TPA_BK010831.1 DAC80016.1 tpg 337577 338851 - ISH8-type transposase ISH8 Loose gnl|BL_ORD_ID|2034|hsp_num:0 vanJ 30.0 3002914 glycopeptide antibiotic antibiotic target alteration vanJ membrane protein teicoplanin MRRLTTLFPSEFLEEHAEELGVVERDRKLQIPVFVWAFVFGFAAGERRTLAGFRRSYNSTADEPISPGGFYQRLTPTLAEYFRDLVEHGLDEVAVPDTVDVDIDRFSDVMIADGTVLRLHEFLADQFEARHEEQAGAKLHLLHNATEQTIERIDVTDEKAHDSTLFKTGSWLENRLVLFDLAYFKYRRFARIDENGGSFVSRLKQNANPVITDELREWRGRAIPLEGKQLRDVLDDLDRTYIDVEVEVEFKRGPYNGTRSLDTKRFRVVGVRDEDADDYHLYVTNLSREEFFPADLAQIYRCRWEVELLFRELKTQYDLDEFDTSNEHVVKILLYAALLSLLVSRDLLDLVTEQADDELVFPPERWAATFRSHAQLILHELGEHLGYSPPPLLERLIEDAQKIHKQRPILQETLATATQPRCES TPA_BK010831.1 DAC80017.1 tpg 339116 339496 - uncharacterized protein Loose gnl|BL_ORD_ID|131|hsp_num:0 cpxA 63.64 3000830 aminoglycoside antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump neomycin; amikacin; kanamycin A; tobramycin; novobiocin; gentamicin MVSGWQVIRVACILSVSVGVGLLAISISLGLTAGTAPPVLVGFGGSVCTAYLLLRKHPNIETGPLWRFSGLVFVLFILGNAVSTEGIYAPQSEQSPLAIGGVWALSLLICYTVIFKVEWTNRSPSQ TPA_BK010831.1 DAC80019.1 tpg 340219 341337 + XerC/D-like integrase Loose gnl|BL_ORD_ID|1374|hsp_num:0 ACT-4 40.62 3001829 carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation ACT beta-lactamase MSNNDATPGVRGLETLLDDRMVSLESPQTQQITRVAVNNLFQFLTENNDVDSVADVDEQDARDWVIHLVKEDDLAANSIRTYFALARATFGWWQRSGEIGQNPLATTTAEEVLPSKSNDVEQQFWTADARERLLNYVDERAHAALENDSSDAARAFRDRSLVYILADTGVRGAEICSVSRDNRRNGLRWTDVDLEAGVMTVLGKSGDQESVSLPGVTSEKLARYRRLVDAPAEWPVIPTGDATSKYRAVRKQLREREYGDEAIEGVLEDCEIDEVLREYEVAPPALTTEGARTLLKRLCGEADVDIDGDYLKPHGGRRGLGDELYGEVAAESAQEVLRHKSIETTHASYRERRAEDLSADIEKVRYSNTDEE TPA_BK010831.1 DAC80020.1 tpg 342611 342970 - thioredoxin Loose gnl|BL_ORD_ID|2297|hsp_num:0 Pseudomonas aeruginosa CpxR 34.55 3004054 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; aminoglycoside antibiotic; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump neomycin; erythromycin; amikacin; ciprofloxacin; kanamycin A; tetracycline; tobramycin; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; panipenem; trimethoprim-sulfamethoxazole; gentamicin MATDTAATTGTASPDEPLYVNGQTELDDVTSDNDVVLADFYADWCGPCQMLEPVVETLAEQTDAAVAKIDVDENQALASAYGVRGVPTLVLFADGEQVEEVVGLQDEDALKDLIESYTE TPA_BK010831.1 DAC80021.1 tpg 343146 343550 - TrmB family transcription regulator Loose gnl|BL_ORD_ID|810|hsp_num:0 APH(6)-Ib 32.26 3002658 aminoglycoside antibiotic antibiotic inactivation APH(6) streptomycin MPDSMSEQLRQDMECEGLLECFHGLKELDKECFQALVEAEEPMTVDELAEAVDRERSTAYRAVQRLLQTGFIEKEQVNYEQGGYYHVYSPSDPSQITDDMQRMLNDWYAKMGQLIQEFETKYEQPDSVPQSAES TPA_BK010831.1 DAC80024.1 tpg 345030 346295 - major facilitator superfamily transport protein Loose gnl|BL_ORD_ID|1484|hsp_num:0 tet(41) 24.77 3000569 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MSTTTELRQGIREHLGQFSLHVLLVFATGLTIGSERTVVPVLGEDVLGVESFLVIGSFVVSFGIVKSILNLYAGKWGEAYGRKPVLIAGWATALPLPIILIFAPSWGWITVGNVLLGINQALTWSMAINAKIDLAGPDQRGLAVGIDEAFGYTGVAVGAWITGVIAGQWSLRPEPFYFLAVVVVLAFLISIFLIKETVQYAQAEGNDDHHDANLPFNEVLKRATYGDRTLFAAAQAGHIENFVDTLFWIAVPLYLTSQGLGIAAVGVVVGVHSAMYFLQIATGGLADRIGRRPPVVAGMFLAGAGVLGMVLVDGYLPWAVLAGVSGLGMALLYPNLMTVPSDAAHPTWRSAGMGVYRMWRDSGYAVGAVLIGLSMEFVNAAAAFYLTAGLMFASGAVVYVWMEETHPDFGTHEPPAPAPSD TPA_BK010831.1 DAC80025.1 tpg 346299 347408 - rhodanese domain protein / beta-lactamase domainprotein Loose gnl|BL_ORD_ID|1587|hsp_num:0 IND-4 25.81 3002260 carbapenem antibiotic inactivation IND beta-lactamase MQELSPAELGEQVQDDDGPLVLDIRHEEDFQEWHIPGSRNVDVYDELTDDPEQAIEPLDDLPSDEQIVTVCAAGVVSQTATAVLRELGYDAVTLTDGMNGWSRVHRHAELPVDVDGTLVQVARPGKGCLSHVLVSDGEAAVFDPSHYLNEYDTVLDEYDAELVGVFDTHAHADHVSGAADLADRHDVPYYLHQKDALAVDATPLEDGQTVTVGRLDIEVIHTPGHSEGSVSFDVEGAALLTGDTLFHDSVGRVELGVEAGIEDADVEGNAATLYESLQRLLDRPDDALVLPAHDPGSPEPPVAATLAEVRERNDDLGRDREAFVEELASDIPDHPPNFERVKRTNVGQESVPEEELAELELGPNNCAAE TPA_BK010831.1 DAC80026.1 tpg 347456 348232 + HTH-10 family transcription regulator Loose gnl|BL_ORD_ID|2576|hsp_num:0 ADC-164 40.54 3006336 cephalosporin antibiotic inactivation ADC beta-lactamases pending classification for carbapenemase activity MTGTANYVEFEPTRMGLYEASIRVKHECPYRRISERYPDLTIREWPLSDCQVLEITTETTPTDELLDEINEIGTVLYESADDNGYHVVTQSCLCSLEDSVIDRFEEHNCLYQSPTIYRQGWEHYTVVAFDSEDVRELLDSLRSDREIELLSKTSISETQIPHSMLAPANQLFEDITDRQLAALQLALESGYYEQPRKTSLRDLAERTAVARSTYEEHLRKAENKLLTNAGQFLRLVTATSTTNPLGVESGRRTEQTAD TPA_BK010831.1 DAC80027.1 tpg 348249 349424 - transport protein (probable substratephosphate/sulfate) Loose gnl|BL_ORD_ID|2428|hsp_num:0 rpoB2 37.78 3000501 rifamycin antibiotic antibiotic target alteration; antibiotic target replacement rifamycin-resistant beta-subunit of RNA polymerase (rpoB) rifampin; rifaximin; rifabutin; rifapentine MDPALIALFAGAALASLFMAWVIGAGSSGATPYAPAVGANAISTMRAALLVGIFGFVGAVTQGGNVSEAIGSGLVGGISLPIAGVILVLVLGAGLMAIGITTGYPIATAFTVTGAVIGVGLALGGSPVWPKYQQIAAVWVLTPFVGGGIAFTIASLLPRPGVPERYSIPVLAGLVGAVLVNIQFSFLGAGSAAGTVRGVGQRVLAVDGLTSAVGITGFAALVVATVVWWDVSRDERGGLRRVLLALGSLVAFSAGGSQVGLAVGPLLPLLDEVGMVSTFAVLVGGGLGMLVGSWTGAPRMIKSLAQDYSSLGPRRSISALVPSFLIAQLAVLLGVPVSFNEIVVSAIIGSGAAVGGREAVDARKIGVTIGAWIGSFALSFALAYAAGALLL TPA_BK010831.1 DAC80028.1 tpg 349435 349893 - DUF4341/DUF395 family protein Loose gnl|BL_ORD_ID|467|hsp_num:0 tetA(P) 21.62 3000180 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MSDRHPAFMPLILVGGLIFGFGLAYSQMARPEVVLNFLQFEDFGLVFVMFGGAAVTGVTFFVAPRLLGRAPLTGDSFQRRLKSFDRNVLIGGAIFGVGWGLSGICPGAAYASLGIGNITILWALAGMFLGAYTQGFWRSHSQSRDASSAGAD TPA_BK010831.1 DAC80030.1 tpg 350393 351586 - rhodanese domain protein / beta-lactamase domainprotein Loose gnl|BL_ORD_ID|3333|hsp_num:0 CAR-1 35.11 3006903 carbapenem antibiotic inactivation CAR beta-lactamase MNADDFPTPDADVESVDPESLKDRIDAGEDVTLLDARMTSDYEEWHIDGENVTSINVPYFEFLEDDIDEDVLDQIPDDREVTVLCAKGGASEFVAGTLAERDYDVDHLEDGMNGWARIYDAVEVEGYDGAGTLLQYQRPSSGCLGYLLYDDGEAAIIDPLRAFTDRYLDDADNLGVDLQYALDTHVHADHISGVRNLAEEDIEGVIPEAAVDRGITYADDMTTAADGDTFDVGDATIEAVYTPGHTTGMTSYLVDDSLLATGDGLFIESVARPDLEEGDDGAPDAARMLYESLQERVLTLPDDTLVGGAHFSDAADPAADGTYTAPIGELVDEMDALTMDEQAFVDLVLSDMPPRPANYEDIIATNLGQNAVDDEEAFTLELGPNNCAASQDSLAGD TPA_BK010831.1 DAC80031.1 tpg 351836 352081 + UPF0033 family protein Loose gnl|BL_ORD_ID|741|hsp_num:0 mecC 41.38 3001209 penam antibiotic target replacement methicillin resistant PBP2 methicillin MSADYDITETLDVKGASCPMPVVKTKSAIDDLAEGEILEVLATDSGSMSDIDGWASGTAGVELVDQEEGDDVYKHYVRKTK TPA_BK010831.1 DAC80032.1 tpg 352084 352656 + DsrE domain protein Loose gnl|BL_ORD_ID|4843|hsp_num:0 MCR-4.6 38.89 3007231 peptide antibiotic antibiotic target alteration MCR phosphoethanolamine transferase colistin A; colistin B MSTDTPDASVDDAPSRAELAARVNELEDALAEATSEDDAKKMSIISTKGTLDMAYPPLILASTAAAFGYEVTVFHTFWGLEILHEERSKNLKLSSVGNPNMPVPNAVAALPGMDRVTTKMMEKKIDDNDTATIEELIETSLDMGVEFQACQMTIDLMDYDEDDFYDGVTTGVGAATALQDMAEADIQLLV TPA_BK010831.1 DAC80033.1 tpg 352775 353770 - cytochrome bd ubiquinol oxidase subunit II Loose gnl|BL_ORD_ID|1197|hsp_num:0 mef(B) 44.19 3003107 macrolide antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump erythromycin; azithromycin MTDPLIPVDTYLVDSLPEVWFGAVVFALGMYIVLDGFDFGIGMLYATRTDEHERETFLAAFGPVWDANEVWIVAFGTMLLAAFPRVYSRLLADNYLLALGFVVALVFRGLGPELREQREDERWKRYTDYAFVGGSVFAPLLLGMLAGRWLFAGATLPVVLTGVGLVAVSIVTGAAFLAAKTDSGLASELRSYGVGATVAYLGGVVVLLGTVVATDAGGAASAVLSLPVAAVVALSIVAGLGGSVLARRGRYRAWLASALALPTLLTLLVAVLLYPTVYPPTGLLVREAVVSPLALNLVTVLGFPVLLLVLWYFKFLYGVFSGPIEGEGYGG TPA_BK010831.1 DAC80034.1 tpg 353763 355211 - cytochrome bd ubiquinol oxidase subunit I Loose gnl|BL_ORD_ID|3409|hsp_num:0 CRP-1 25.97 3006868 carbapenem antibiotic inactivation CRP beta-lactamase MVPATLLSTVDLGWMALLSPEIASRMQFGWTISVHIIFASLSIGLAPFIIYFTWKDVRTNEQRYARLRSFWVKVFAVGFVMGTVTGIPMSFQFGTNFPQFATIAGELIGGPLAFEAKMAFFLEAVFLGVLLYGRERVADRTYVLSSVLVGVGAWLSGFWILVVNAWMQTPRGYEMVTRNGMEVAKLTDPVAAFLTPRMPWMYVHMMNASVISVALLVAGVSAYLVWKKPDADAWNSALKLAVVLLLVSAPFQAVHGDAYGRHVEDTQPQKFAAMEAHYETGSADLHLLAFPKSLDALTDPRTENLFTVSLPGIGSFLASGGDFDAEVIGLNEYEENPPVALVFWSFRFMVGLGFLFIGLALWGGYLTYRGRLTESTRYLKSMIAASPFGYAALLTGWYVTEIGRQPWVIQGELKTSEAVSSTLTGTEATLTLVGFVVLYIALILTALYVLKWLIRGELRSLGVQESSAGRWRGPLPWVTSDD TPA_BK010831.1 DAC80036.1 tpg 356266 356649 + uncharacterized protein Loose gnl|BL_ORD_ID|4680|hsp_num:0 vanS gene in vanF cluster 30.43 3002936 glycopeptide antibiotic antibiotic target alteration vanS; glycopeptide resistance gene cluster vancomycin MFTVDETYDGFEFTLRNQTTASLTITRTKAWEIERHTSDGWEQVATEVGVAEGKTRTLDCGEAHSWHHALFEHPTLPSRKTTYLFENLSEGLYKFSVTGNLETGVEITRETQFEVQRQLPPQTKTDE TPA_BK010831.1 DAC80037.1 tpg 356721 356891 + small CPxCG-related zinc finger protein Loose gnl|BL_ORD_ID|3290|hsp_num:0 AXC-3 40.0 3006899 carbapenem antibiotic inactivation AXC beta-lactamase MGENCDKCGTELGSSQERHQRYRIEHPSDSVETLEGRLCSDCFWELKEWLETEEVT TPA_BK010831.1 DAC80039.1 tpg 357683 357964 - PadR family transcription regulator Loose gnl|BL_ORD_ID|2039|hsp_num:0 mphG 28.57 3003742 macrolide antibiotic antibiotic inactivation macrolide phosphotransferase (MPH) erythromycin; clarithromycin; azithromycin MHDLTGFQRDILYVIADFEEPHGLALKDELEVYYEQEINHGRLYPNLDDLVDKGLVEKGELDERTNSYTLTQRGHREITARRDWEQQYVDLSE TPA_BK010831.1 DAC80040.1 tpg 358097 358264 + uncharacterized protein Loose gnl|BL_ORD_ID|4666|hsp_num:0 vanS gene in vanB cluster 45.83 3002932 glycopeptide antibiotic antibiotic target alteration vanS; glycopeptide resistance gene cluster vancomycin MSDLIVKAAVKDELSEHNVSADFYAALNEEVAELLDDAADRAEANERKTVQPRDL TPA_BK010831.1 DAC80041.1 tpg 358568 358789 + uncharacterized protein Loose gnl|BL_ORD_ID|2305|hsp_num:0 tetA(46) 33.33 3004032 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MNYPSLRGYGAVLVVGVAVICMGVIALGFIMPTRLFESTVGLVAFFAAALLMVICAVVANFYDLREVLHEEFG TPA_BK010831.1 DAC80042.1 tpg 358948 359217 + uncharacterized protein Loose gnl|BL_ORD_ID|2347|hsp_num:0 basS 41.46 3003583 peptide antibiotic antibiotic target alteration; antibiotic efflux pmr phosphoethanolamine transferase polymyxin B MSQNTVNTTVSIKPADALFLSWATGTNASGLFREAVAEQMMYRDIDRDELSTLTEEALTETSRDLDDLLEQTSSIEDLNTLLETDPASD TPA_BK010831.1 DAC80043.1 tpg 359657 360649 - ISH11-type transposase Loose gnl|BL_ORD_ID|4561|hsp_num:0 RAHN-2 35.29 3006980 cephalosporin antibiotic inactivation RAHN beta-lactamase MSPATLQDDPSVDSFFNVVETETLALFEHLSFEFLEEFDVFAPAETGRTRDHEPPELMRGFLHCYYKDIYGIRPVERELRNTVVWLSCGFDRPPSRDAVDRFLTDLEHVVNKVFDHLVEQAALRGLLDLTYCIDSTDVRAMPADQDASKCYDPTDDEYYHGYGCTIVSTGQKIPIAAEFTESKQAPEETAMRVTRDALAVAKPIWMVGDSAYDTLDWHDHLLAAGVVPVAPYNARNTDDPKDIEYRVEDRIEQHSEDVQLKQSTLDETYNRRTGVERTNESVKDCGLGRTHARGRVHARAQVFLALCLRLVVAITNYERGDNPGSPIITV TPA_BK010831.1 DAC80044.1 tpg 362107 362934 - ISH9-type transposase ISH9 Loose gnl|BL_ORD_ID|1560|hsp_num:0 Erm(39) 38.46 3000602 macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase erythromycin; roxithromycin; lincomycin; telithromycin; clarithromycin; clindamycin; tylosin; spiramycin; azithromycin; dirithromycin; pristinamycin IA; quinupristin; virginiamycin M1; madumycin II; griseoviridin; dalfopristin; pristinamycin IB; virginiamycin S2; pristinamycin IC; vernamycin C; patricin A; patricin B; ostreogrycin B3; oleandomycin MSKISRFTKKAVQLAKNAVGGRGEVAAPEGGGGFADYAIVSLHCLRVYLEKSYRETLDLLSEMPHILAEIGLNEADLPDHSTLVKAFDRLKTALWRVLLRLSAQLHDPSGHAAIDATFFDRETASKHYCRRTNYRVQTLKTTALVDTETQAILDVHCSTGKPHDTQLGWQVARRNAGDLASLAADKGYDWMELRKKLREDGVRPLIKHRIFRPIDHAHNARVDGPRYRQRAMCETVFSTIKRTLGDAVRARAWFREFREIVLKCVVHNIKRAVTP TPA_BN000925.1 CAJ85666.1 tpe 366 1502 - KlaB protein Loose gnl|BL_ORD_ID|251|hsp_num:0 CTX-M-11 34.04 3001874 cephalosporin antibiotic inactivation CTX-M beta-lactamase MNALKTTHDAKAPIVAFDMTPATLRELGLQESDVPEVHAVAQRIEVGSPQTVAEFGRDVAEHTSRYADSLLDQVRNSDLDEAGEKLTQVVAKARSLNVGPLSDNRSRLPLIGPLIDRFRVRSTGFMARFDTTREQIEHLVSEVQTTQQGIAQRNASLDEMFAAVREEHRLLGVHIAAGKVRLAELREQAEGLRGNVGNDPGRVQELADLDAMVANLDKRIGDLIALQHSAMQSLPTIRMIQANNQMLVDKFHTIREITVPAWKRQFMLALSLNEQKNAVELATAIDDTTNDLMKRNAALLHRTSVETAKENQRLVIDVDTLKQVQTTLIKTVEDVIRIQQEGVQKRKDAEKQIAAMRGDLQAKLTRQPVRELAQQESV TPA_BN000925.1 CAJ85667.1 tpe 1520 2293 - KlaA protein Loose gnl|BL_ORD_ID|2332|hsp_num:0 nalD 35.0 3000819 macrolide antibiotic; fluoroquinolone antibiotic; monobactam; carbapenem; cephalosporin; cephamycin; penam; tetracycline antibiotic; peptide antibiotic; aminocoumarin antibiotic; diaminopyrimidine antibiotic; sulfonamide antibiotic; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; ciprofloxacin; tetracycline; ceftazidime; ceftriaxone; meropenem; novobiocin; azithromycin; trimethoprim; sulfamethoxazole; chloramphenicol; aztreonam; colistin A; colistin B; ampicillin; nalidixic acid; panipenem; ticarcillin; trimethoprim-sulfamethoxazole MEEQSVNMARLKGEVLPALFASPATIGEYGAGIDGADSLNELSNLMEHGAVAALADKISQIVAKLADADPRKIAEKPTWFEKMLGREVERQVRYQVARKTLDQLLDEAEGVAQRVRDTLRALDDMLNTHEAEVDRLRAYIQAGREFLDENPEAGAAKAGVIEFDKPRERFARKLANLATLMASHEMSVTQMKLTRAQAVDMLDRFSETASVLVPVWRQHTLALITTKNMNPAMVAEAAKAHQALMRSLSQSLEGINQ TPA_BN000925.1 CAJ85668.1 tpe 2416 2730 - KleF protein Loose gnl|BL_ORD_ID|1898|hsp_num:0 blaR1 43.75 3000217 penam antibiotic inactivation BlaZ beta-lactamase MPRQEPKQPGYVCPTTGRVAVLVKDYADSDLNGDASAYWFNPEAEGWGMDPWKLVEGVDPHTQGCSMDVCFADGSSKTVGPLMTFFLSAKDAARLAALKGQRQE TPA_BN000925.1 CAJ85670.1 tpe 2758 3081 - KleE protein Loose gnl|BL_ORD_ID|1250|hsp_num:0 cmx 37.5 3002703 phenicol antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump chloramphenicol MSKIIKFPGVEVEAEAPAPRVEAPSKAPPRFTFAKGVQALVRFVWVVTVLVWPVAKWIISIDVFFQFLRMLYHWNTLGVHAGWTFLVHFAVLTALTYFVSLYKPKGL TPA_BN000925.1 CAJ85671.1 tpe 3193 3411 - KleD protein Loose gnl|BL_ORD_ID|4989|hsp_num:0 putative nickel/cobalt transporter 71.43 3007659 fluoroquinolone antibiotic; aminoglycoside antibiotic; isoniazid-like antibiotic antibiotic efflux metal transporters with antibiotic efflux isoniazid; nalidixic acid; norfloxacin; ofloxacin; sparfloxacin; gentamicin MQVGDRVNWQHTPRGGYGYSVCVAGIVTKIAAKRVQIRVAVRSGNEWQQVTKWVEPARLSTREKPVPELDGA TPA_BN000925.1 CAJ85672.1 tpe 3427 3657 - KleC protein Loose gnl|BL_ORD_ID|4326|hsp_num:0 PDC-266 33.33 3006642 monobactam; carbapenem; cephalosporin antibiotic inactivation PDC beta-lactamase MTDKFMPWIDELPNVDQELVAQRNAIAEKQRRADELMHQVERLRIEVMRESSRLEERAKQRWTFNEIDLAKFRAGH TPA_BN000925.1 CAJ85673.1 tpe 3810 4025 - KleB protein Loose gnl|BL_ORD_ID|1710|hsp_num:0 rmtA 47.62 3000859 aminoglycoside antibiotic antibiotic target alteration 16S rRNA methyltransferase (G1405) dibekacin; amikacin; gentamicin C; sisomicin; netilmicin; kanamycin A; tobramycin; isepamicin; G418; arbekacin; gentamicin B; gentamicin MPNRKIEIVTTNCRRCGKSISTLSRSLIGADALREELGGICGDCITPEERQRIEQGTLLAALRQCAAAGTS TPA_BN000925.1 CAJ85674.1 tpe 4074 4307 - KleA protein Loose gnl|BL_ORD_ID|1306|hsp_num:0 acrD 38.71 3000491 aminoglycoside antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump neomycin; amikacin; kanamycin A; tobramycin; gentamicin MKSKIMSWLDELPGAAATDFLARRDQIAALMEQAAELTRQAEELRHKAYLQGCTLEGEAKGHWSTQEVERAKARAGW TPA_BN000925.1 CAJ85677.1 tpe 5639 6499 - beta lactamase Perfect gnl|BL_ORD_ID|381|hsp_num:0 TEM-2 100.0 3000874 monobactam; cephalosporin; penam; penem antibiotic inactivation TEM beta-lactamase ceftazidime; ampicillin MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDKLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW TPA_BN000925.1 CAJ85679.1 tpe 7402 10407 + Tn1 transposase Loose gnl|BL_ORD_ID|1306|hsp_num:0 acrD 28.92 3000491 aminoglycoside antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump neomycin; amikacin; kanamycin A; tobramycin; gentamicin MPVDFLTTEQTESYGRFTGEPDELQLARYFHLDEADKEFIGKSRGDHNRLGIALQIGCVRFLGTFLTDMNHIPSGVRHFTARQLGIRDITVLAEYGQRENTRREHAALIRQHYQYREFAWPWTFRLTRLLYTRSWISNERPGLLFDLATGWLMQHRIILPGATTLTRLISEVREKATLRLWNKLALIPSAEQRSQLEMLLGPTDCSRLSLLESLKKGPVTISGPAFNEAIERWKTLNDFGLHADNLSTLPAVRLKNLARYAGMTSVFNIARMSPQKRMAVLVAFVLAWETLALDDALDVLDAMLAVIIRDARKIGQKKRLRSLKDLDKSALALASACSYLLKEETPDESIRAEVFSYIPRQKLAEIITLVREIARPSDDNFHEEMVEQYGRVRRFLPHLLNTVKFSSAPAGVTTLNACDYLSREFSSRRQFFDDAPTEIISRSWKRLVINKEKHITARGYTLCFLSKLQDSLRRRDVYVTGSNRWGDPRARLLQGADWQANRIKVYRSLGHPTDPQEAIKSLGHQLDSRYRQVAARLGENEAVELDVSGPKPRLTISPLASLDEPDSLKRLSKMISDLLPPVDLTELLLEINAHTGFADEFFHASEASARVDDLPVSISAVLMAEACNIGLEPLIRSNVPALTRHRLNWTKANYLRAETITSANARLVDFQATLPLAQIWGGGEVASADGMRFVTPVRTINAGPNRKYFGNNRGITWYNFVSDQYSGFHGIVIPGTLRDSIFVLEGLLEQETGLNPTEIMTDTAGTSELVFGLFWLLGYQFSPRLADAGASVFWRMDHDADYGVLNDIARGQSDPRKIVLQWDEMIRTAGSLKLGKVQASVLVRSLLKSERPSGLTQAIIEVGRINKTLYLLNYIDDEDYRRRILTQLNRGESRHAVARAICHGQKGEIRKRYTDGQEDQLGALGLVTNAVVLWNTMYMQAALDHLRAQGETLNDEDIARLSPLCHGHINMLGHYSFTLAELVTKGHLRPLKEASEVENVA TPA_BN000925.1 CAJ85680.1 tpe 11198 11638 - KlcA putative anti-restriction protein Loose gnl|BL_ORD_ID|4722|hsp_num:0 salE 37.5 3007029 lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; pleuromutilin antibiotic antibiotic target protection sal-type ABC-F protein tiamulin; retapamulin MTDVQIPSPIVATRVAEADRLRFLPTYFGPSMLRMLRGEALVFGWMGRLCAAYHGGFWHFYTLSNGGFYMAPEHDGRLRIEVDGNGFAGELSADAAGIVATLFALNQLCAELAGTADADALIDRYHHLAAFASEHAEAAAIYRAID TPA_BN000925.1 CAJ85681.1 tpe 13294 13944 - tetracycline resistance repressor protein Loose gnl|BL_ORD_ID|442|hsp_num:0 tetR 52.97 3003479 tetracycline antibiotic antibiotic target alteration; antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MTKLQPNTVIRAALDLLNEVGVDGLTTRKLAERLGVQQPALYWHFRNKRALLDALAEAMLAENHTHSVPRADDDWRSFLIGNARSFRQALLAYRDGARIHAGTRPGAPQMETADAQLRFLCEAGFSAGDAVNALMTISYFTVGAVLEEQAGDSDAGERGGTVEQAPLSPLLRAAIDAFDEAGPDAAFEQGLAVIVDGLAKRRLVVRNVEGPRKGDD TPA_BN000925.1 CAJ85682.1 tpe 14050 15249 + tetracycline exporter protein Strict gnl|BL_ORD_ID|1790|hsp_num:0 tet(A) 97.47 3000165 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MKPNIPLIVILSTVALDAVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALVQFACAPVLGALSDRFGRRPILLVSLAGATVDYAIMATAPFLWVLYIGRIVAGITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQLVGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGAALYLLCLPALRRGLWSGAGQRADR TPA_BN000925.1 CAJ85683.1 tpe 15881 16546 - hypothetical protein Loose gnl|BL_ORD_ID|442|hsp_num:0 tetR 65.62 3003479 tetracycline antibiotic antibiotic target alteration; antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MTWCIANARALWGQFRLGVQQPALYWHFRNKRALLDALASLSIARAHGALYELPINRGLKLTIVIKAQIRRLGAADVQDFREIRLSALKKAPEMFGSVYEHEEKKPMEAFAERLRDAVAFGAYIDGEIIGLSVFKQEDGPKDAHKAHLSGVFVEPEQRGRGVAGMLLRALPAGLLLVMIVRQIPTGIWWMRIFILGALNISLFWSLLFISVYRLPGGSRRR TPA_BN000925.1 CAJ85684.1 tpe 16521 17669 - TrfA replication protein Loose gnl|BL_ORD_ID|4948|hsp_num:0 TEM-246 32.65 3007448 monobactam; cephalosporin; penam; penem antibiotic inactivation TEM beta-lactamase ceftazidime; ampicillin MNRTFDRKAYRQELIDAGFSAEDAETIASRTVMRAPRETFQSVGSMVQQATAKIERDSVQLAPPALPAPSAAVERSRRLEQEAAGLAKSMTIDTRGTMTTKKRKTAGEDLAKQVSEAKQAALLKHTKQQIKEMQLSLFDIAPWPDTMRAMPNDTARSALFTTRNKKIPREALQNKVIFHVNKDVKITYTGVELRADDDELVWQQVLEYAKRTPIGEPITFTFYELCQDLGWSINGRYYTKAEECLSRLQATAMGFTSDRVGHLESVSLLHRFRVLDRGKKTSRCQVLIDEEIVVLFAGDHYTKFIWEKYRKLSPTARRMFDYFSSHREPYPLKLETFRLMCGSDSTRVKKWREQVGEACEELRGSGLVEHAWVNDDLVHCKR TPA_BN000925.1 CAJ85685.1 tpe 16521 17378 - TrfA replication protein Loose gnl|BL_ORD_ID|4948|hsp_num:0 TEM-246 32.65 3007448 monobactam; cephalosporin; penam; penem antibiotic inactivation TEM beta-lactamase ceftazidime; ampicillin MTTKKRKTAGEDLAKQVSEAKQAALLKHTKQQIKEMQLSLFDIAPWPDTMRAMPNDTARSALFTTRNKKIPREALQNKVIFHVNKDVKITYTGVELRADDDELVWQQVLEYAKRTPIGEPITFTFYELCQDLGWSINGRYYTKAEECLSRLQATAMGFTSDRVGHLESVSLLHRFRVLDRGKKTSRCQVLIDEEIVVLFAGDHYTKFIWEKYRKLSPTARRMFDYFSSHREPYPLKLETFRLMCGSDSTRVKKWREQVGEACEELRGSGLVEHAWVNDDLVHCKR TPA_BN000925.1 CAJ85686.1 tpe 17718 18068 - single stranded DNA binding protein Loose gnl|BL_ORD_ID|3526|hsp_num:0 FIA-1 40.0 3006887 carbapenem antibiotic inactivation FIA beta-lactamase MSHNQFQFIGNLTRDTEVRHGNSNKPQAIFDIAVNEEWRNDAGDKQERTDFFRIKCFGSQAEAHGKYLGKGSLVFVQGKIRNTKYEKDGQTVYGTDFIADKVDYLDTKAPGGSNQE TPA_BN000925.1 CAJ85687.1 tpe 18189 18554 + TrbA repressor protein Loose gnl|BL_ORD_ID|1249|hsp_num:0 AAC(6')-I30 32.35 3002588 aminoglycoside antibiotic antibiotic inactivation AAC(6') dibekacin; amikacin; sisomicin; netilmicin; tobramycin; 2'-N-ethylnetilmicin; 5-episisomicin MYNQIFFTNILRLLDERGMTKHELSERAGVSISFLSDLTNGKANPSLKVMEAIADALETPLPLLLESTDLDREALAEIAGHPFKSSVPPGYERISVVLPSHKAFIVKKWGDDTRKKLRGRL TPA_BN000925.1 CAJ85688.1 tpe 18825 19784 + TrbB protein Loose gnl|BL_ORD_ID|2048|hsp_num:0 salA 23.58 3003749 lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; pleuromutilin antibiotic antibiotic target protection sal-type ABC-F protein lincomycin; clindamycin; virginiamycin M1; tiamulin; retapamulin MSGKEEFQTIKERAKRKLERDMGADLLAALNDPKTVEVMLNADGKVWHERLGEPMRYICDMRPSQSQAIIETVAGFHGKEVTRHSPILEGEFPLDGSRFAGQLPPVVAAPTFAIRKRAVAIFTLEQYVEAGIMTREQYEVIKSAVAAHRNILVIGGTGSGKTTLVNAIINEMVAFNPSERVVIIEDTGEIQCAAENAVQYHTSIDVSMTLLLKTTLRMRPDRILVGEVRGPEALDLLMAWNTGHEGGAATLHANNPKAGLSRLAMLISMHPDSPKPIEPLIGEAVHVVVHIARTPSGRRVQEILEVLGYENGQYITKTL TPA_BN000925.1 CAJ85690.1 tpe 20237 20548 + TrbD protein Loose gnl|BL_ORD_ID|2054|hsp_num:0 Brucella suis mprF 28.95 3003772 peptide antibiotic antibiotic target alteration defensin resistant mprF defensin MALRTIPIRRAGNRENLFMGGDRELVMFSGLMAFALIFSAQELRATVVGLILWFGALYAFRIMAKADPKMRFVYLRHRRYKPYYPARSTPFRENTNSQGKQYR TPA_BN000925.1 CAJ85691.1 tpe 20545 23103 + TrbE protein Loose gnl|BL_ORD_ID|4719|hsp_num:0 salB 25.88 3007026 lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; pleuromutilin antibiotic antibiotic target protection sal-type ABC-F protein lincomycin; clindamycin; virginiamycin M1; tiamulin; retapamulin MIQAIAIAIAGLGALLLFILFARIRAVDAELKLKKHRSKDAGLADLLNYAAVVDDGVIVGKNGSFMAAWLYKGDDNASSTDQQREVVSARINQALAGLGSGWMIHVDAVRRPAPNYAERGLSAFPDRLTAAIEEERRRHFESLGTMYEGYFVLTLTWFPPLLAQRKFVELMFDDDATAPDRKARTRGLIDQFKRDVRSIESRLSSAVSLTRLKGHKIVNEDGTTVTHDDFLRWLQFCVTGLHHPVQLPSNPMYLDALVGGQEMWGGVVPKVGRKFVQVVALEGFPLESYPGILTALGELPCEYRWSSRFIFMDQHEAVKHLDKFRKKWRQKIRGFFDQVFNTNTGPVDQDALSMVADAEAAIAEVNSGIVAVGYYTSVVVLMDEDRTRLEAAARDVEKAVNRLGFAARIESINTLDAFLGSLPGHGVENVRRPLINTMNLADLLPTSTIWTGNANAPCPMYPPLSPALMHCVTQGSTPFRLNLHVRDLGHTFMFGPTGAGKSTHLAILAAQLRRYAGMSIFAFDKGMSMYPLAAGIRAATKGTSGLHFTVAADDERLAFCPLQFLSTKGDRAWAMEWIDTILALNGVETTPAQRNEIGNAIMSMHASGARTLSEFSVTIQDEAIREAIRQYTVDGAMGHLLDAEEDGLALSDFTVFEIEELMNLGEKFALPVLLYLFRRIERALTGQPAVIILDEAWLMLGHPAFRAKIREWLKVLRKANCLVLMATQSLSDAANSGILDVIVESTATKIFLPNIYARDEDTAALYRRMGLNARQIEILAQAVPKRQYYYVSENGRRLYDLALGPLALAFVGASDKESVAIIKNLEAKFGDQWVDEWLRGRGLALDEYLEAA TPA_BN000925.1 CAJ85692.1 tpe 23100 23858 + TrbF protein Loose gnl|BL_ORD_ID|3966|hsp_num:0 OXA-732 25.58 3005937 penam antibiotic inactivation OXA beta-lactamase oxacillin MSFADTIKGLIFKKKPATAAAAATPAATGPQTDNPYLTARRTWNDHVGSVVSQKQTWQVVGILSLMIVLAAVGGIIHIGSQSKFVPYVYEVDKLGQTAAVGPMTRASKADPRVIHASVAEFVGDARLVTPDVALQRKAVYRLYAKLGPNDPATAKMNEWLNGTADASPFARAAVETVSTEITSVIPQTPDTWQVDWVETTRDRQGVVKGQPVRMRALVTVYVVEPTADTKEEQLRNNPAGIYVRDFSWSRLL TPA_BN000925.1 CAJ85693.1 tpe 23870 24763 + TrbG protein Loose gnl|BL_ORD_ID|3523|hsp_num:0 EFM-1 50.0 3006884 carbapenem antibiotic inactivation EFM beta-lactamase MKKELFALVLAASVSVPAFAADPGADLTDLYFSGKNPELTAQERAAIAIAKKWEAGTAGMRPVAGPGGSVRFLFGAQQPSIVCAVLQVCDVALQPGEQVNSINLGDTARWTVEPAITGSGANETQHLIIKPMDVGLETSLVVTTDRRSYHMRLRSHRTQYMPQVSFTYPEDALAKWDAIKNREQRDRVEKTIPQTGEYLGNLSFNYSVSGSTSWKPVRVYNDGKKTIIQMPHSMEQTEAPTLLVVRREGGLFSDDETVMVNYRVQGDRYIVDTIFDKAILIAGVGSSQDRVTISRGN TPA_BN000925.1 CAJ85694.1 tpe 24767 25249 + TrbH protein Loose gnl|BL_ORD_ID|1588|hsp_num:0 vatA 32.43 3002840 streptogramin antibiotic; streptogramin A antibiotic antibiotic inactivation streptogramin vat acetyltransferase virginiamycin M1; madumycin II; griseoviridin; dalfopristin MRKILTVIALAATLAGCATSKYGSFVQDAPAAYNQTIATDAVKQLVKLYPPAQTKLELQQATPDPFGIALVTDLRAQGYAVMEYKPDGNAAAAPAAASSAAAKPATPQAQGGYPLRYVLDQFSDSNLYRLTVMVGSQSLTRAYLAQNNTMVPAGAWVRKE TPA_BN000925.1 CAJ85695.1 tpe 25254 26645 + TrbI protein Loose gnl|BL_ORD_ID|2207|hsp_num:0 OXA-296 41.03 3001751 penam antibiotic inactivation OXA beta-lactamase oxacillin MSEDQMAPDASPDAVKPKSGVRRVNNMPMYLIGGVLGIFLLVMALVAADRAAQQNQPGAAKAEKAGSTSMFADEIAGKQQDGIIKAKPLEIPPEQTAQQPTTELTPAPAQGTTITVARPENLDQPPTPPQGARNEDLDRIRMAKLQMLEEAIKAKTTVRIDAPRSQGSAGGGAPQGREETLARIQELRRQAENARATDPTAAYQAALAQARTMGGAAGGGGMGGSGAPTLVQTSNRSGGGAGYGSFDNRSEGDRWRLDSQPEAPATPYVLRAGFVVPATLISGINSDLPGQIMAQVSQSVYDTATGKHMLIPQGSRLVGSYSNDVAYGQKRVLVAWQRIIFPDGKAMDIGAMPGGDSAGYAGFNDKVNNHYFRTFASAFLMSGVVAGISLSQDRGNSNSGYGRQDAGSAMSEALGQQLGQVTAQMIAKNLNIAPTLEIRPGYRFNVIVTKDMTFSKPYQAFDY TPA_BN000925.1 CAJ85696.1 tpe 26662 27438 + TrbJ protein Loose gnl|BL_ORD_ID|2585|hsp_num:0 OXA-157 60.0 3001462 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-62-like beta-lactamase oxacillin MKKLAKNVLAAKVALVLALSVGTLAVTPAQAGIPVIDGTNLSQTTVTAIQQVAQVQKQIEEYRTQLQQYENMLQNTVAPAAYVWDQAQSTINGLMSAVDTLNYYKNQAGSIDAYLGKFKDVSYYKGSPCFSLSGCSESERKAMEENRRLASESQKKANDALFRGLDQQQSNLKSDAATLEQLKGKATTAQGQLEALGYANQFASQQANQLMQIRGLLLAQQNAIATQMQAQQDRQAQQDAAGAKLREGSYRASPSKTW TPA_BN000925.1 CAJ85697.1 tpe 27450 27659 + TrbK entry exclusion protein Loose gnl|BL_ORD_ID|1147|hsp_num:0 ceoB 58.33 3003010 fluoroquinolone antibiotic; aminoglycoside antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump MKKSNFIAVAALAAVMAASLAGCDNKPDTDKLTCADLPKVTDAAQRAELLKKCPRGEPGGFKPSEKKEW TPA_BN000925.1 CAJ85698.1 tpe 27666 29252 + TrbL protein Loose gnl|BL_ORD_ID|2013|hsp_num:0 MexJ 24.53 3003692 macrolide antibiotic; tetracycline antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; tetracycline; triclosan MKIQTRAAALAVLMLALMPVAAYAQIDNSGILDNVLQRYQNAASGWATVVQNAATWLFWTLTVISMVWTFGMMALRKADIGEFFAEFVRFTIFTGFFWWLLTNGPNFASSIYASLRQIAGQATGLGQGLSPSGIVDVGFEIFFKVMDETSYWSPVDSFVGASLAAAILCILALVGVNMLLLLASGWILAYGGVFFLGFGGSRWTSDMAINYYKTVLGVAAQLFAMVLLVGIGKTFLDDYYSRMSEGINFKELGVMLIVGLILLVLVNKVPQLIAGIITGASVGGAGIGQFGAGTLVGAAATAGAAIATGGASIAAGAAAAAGGAQAIMAAASKASDNVSAGTDILSSMMGGGGGGGGGSAGTSGGDGGGSGGGGGSGGGETPMASAAGDNSSGARGGSSGGGSGGGRSSGGIGATAAKGGRIAADTVANLAKGAGSIAKAKAGEMRASAQERIGDTVGGKIAQAIRGAGAAAQTAATVADSNSQAQEQPAPAPAPSFDDNSLSASNNREAAADADSEVASFVNKPAQS TPA_BN000925.1 CAJ85699.1 tpe 29276 29875 + TrbM protein Loose gnl|BL_ORD_ID|4693|hsp_num:0 Staphylococcus aureus mupA conferring resistance to mupirocin 40.0 3000521 mupirocin-like antibiotic antibiotic target alteration antibiotic-resistant isoleucyl-tRNA synthetase (ileS) mupirocin MQLKKAFSSAALVVALGLGATGSASAQDVLTGDTRLACEAILCLSTGSRPSECSPSLSRYFGIHKRKLSDTLKARLNFLNLCPVSNQTPEMQTLVSSISRGAGRCDASSLNSVLREWRSWDDQFYIGNRLPDYCAAYTGHAYTDFNTTAPRYVGTPEEGGYWIEAADYDRALKEYEAKLKERQQQYGRYGSDAYRRFER TPA_BN000925.1 CAJ85700.1 tpe 29891 30595 + TrbN protein Loose gnl|BL_ORD_ID|4688|hsp_num:0 Bifidobacterium bifidum ileS conferring resistance to mupirocin 29.82 3003730 mupirocin-like antibiotic antibiotic target alteration antibiotic-resistant isoleucyl-tRNA synthetase (ileS) mupirocin MPFAKLLARNALPVVALVAATGFGAADATAARLFPDLSEQMEERVVCSVSAAAKYEIPANILLAIREKEGGKPGQWVKNTNGTYDVGELQFNTAYLGDLAKYGITAQDVAAAGCYPYDLAAWRLRGHIRNDRGDLWTRAANYHSRTPSKNAIYRADLMVKADKWAKWLDARFVTVNYGPSSPAQPAGKGTTLAAADTSAAAPAEAQPMKQGRITRTSLRSSGYVPRQLIINNTP TPA_BN000925.1 CAJ85701.1 tpe 30626 30889 + TrbO protein Loose gnl|BL_ORD_ID|1679|hsp_num:0 bacA 40.48 3002986 peptide antibiotic antibiotic target alteration undecaprenyl pyrophosphate related proteins bacitracin; bacitracin A; bacitracin B; bacitracin F MGIRNLTQRYMNGARAYAAWAASQAKAPFDLLVLGIGPVIVFGLVAHTLLAFLPTWAMYAAGALLVLAALPLALHVLREYALRYGRK TPA_BN000925.1 CAJ85702.1 tpe 30926 31660 + TrbP protein Loose gnl|BL_ORD_ID|2054|hsp_num:0 Brucella suis mprF 34.19 3003772 peptide antibiotic antibiotic target alteration defensin resistant mprF defensin MNTRAMNDASGRASLPAMVIADGTIEALKWLALLPMTGDHVNKYLFNGTLPYLFEAGRLALPLFVFVLAYNLARPGALERGLYGRAMKRLLAFGLVASVPFIALGGVVGGWWPLNVMFTLLAATAMLYLVERGRSVAPIALFVVAGGLVEFCWPALLLAASVWLYLKRPTWAAALMALLSCASLWYINGNLWALAVVPLVIVAAGVDLRVPRLRWAFYTYYPLHLAALWLIRIPMREAGYLFFT TPA_BN000925.1 CAJ85703.1 tpe 31677 32096 + hypothetical protein Loose gnl|BL_ORD_ID|689|hsp_num:0 cmeB 32.61 3000784 macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; fusidane antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; cefotaxime; fusidic acid MQLLKKCTIAALPLLALSGCALLNIPMPTPPGSTPPEMLTVPVAQICRDADKNPVRATELYGKKGLSATGKVQVISEGFKPRYRVLLPPGSASVHAGTDNQLAIKSVSTGQTTRVTGTVKDVSYDHNGCSISLDDAKFY TPA_BN000925.1 CAJ85704.1 tpe 32111 32806 + FiwA Loose gnl|BL_ORD_ID|2044|hsp_num:0 OXA-477 22.32 3003634 penam antibiotic inactivation OXA beta-lactamase; OXA-63-like beta-lactamase oxacillin MLTRLKGFLARRRELKELDVSVVSRPRPAPAELVQVDAREAVWRVPVPGQADRFMSAKPGAINDEMFVVRVDTEAFYRAWLRSSSTGRETRSDNCPLRSEMPQDYKFKHAVQGFAHGRENPVPLAFAGAHQERHRVDIGFSNGVTRSFWLIANKAPSFPIQVHGRESAELLNKVCGLDPAPLSFTELFAQAQRQAPQVATPARPAPAAATRPAPKVQPRPGRSGPRKGRGL TPA_BN000925.1 CAJ85705.1 tpe 32842 33504 + Upf32.8 protein Loose gnl|BL_ORD_ID|586|hsp_num:0 mecR1 60.0 3000215 penam antibiotic target replacement methicillin resistant PBP2 methicillin MYVIACGIVAGLAAAVALLGFTPMMEALAAGERRKALAQWTRTMFLVLLPVVLMCAPIGSSIYDAVQADAGKPIAFHNGRITVVMALVGSLAVVLVAAARAVVNRKHASFWFVGWVMASVLAGGVGAIASAKQLAFLGEHSGMVAFGFFRDQVKDMHCDADVILARWDEKANSPVVYRCPKAYLLNRFASAPFVPWPDYTEGESEDLGRALAAALRDAKR TPA_BN000925.1 CAJ85706.1 tpe 33528 34187 - ParA Loose gnl|BL_ORD_ID|1950|hsp_num:0 otr(C) 45.24 3002894 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MATREQQPEGRRLKVARIYLRASTDEQNLERQESLVAATRAAGYYVAGIYREKASGARADRPELLRMIADLQPGEVVVAEKIDRISRLPLAEAERLVASIRAKGAKLAVPGVVDLSELAAEANGVAKIVLESVQDMLLKLALQMARDDYEDRRERQRQGVQLAKAAGRYTGRKRDAGMHDRIITLRSGGSSIAKTAKLVGCSPSQVKRVWAAWNAQQQK TPA_BN000925.1 CAJ85708.1 tpe 34148 34681 - ParB nuclease Loose gnl|BL_ORD_ID|298|hsp_num:0 vanR gene in vanF cluster 38.71 3002925 glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanR vancomycin MKRRSYAMLRAAAALAVLVVASPAWAELRGEVVRIIDGDTIDVLVDKQPVRVRLVDIDAPEKRQAFGERARQALAGMVFRRHVLVDEKDTDRYGRTLGTVWVNMELASRPPQPRNVNAAMVHQGMAWAYRFHGRAADPEMLRLEQEARGKRVGLWSDPHAVEPWKWRRESNNRRDEG TPA_BN000925.1 CAJ85709.1 tpe 34678 34938 - ParC protein Loose gnl|BL_ORD_ID|2708|hsp_num:0 dfrA18 30.51 3004568 diaminopyrimidine antibiotic antibiotic target replacement trimethoprim resistant dihydrofolate reductase dfr trimethoprim MRAAKHYRQLLSIDFNIEALAFVPGPDGTRGRRIHVLGREVRDRPGLVEYLSPAFGSRVALDGYCKANFDAVLHLAYPDHQQWGHA TPA_BN000925.1 CAJ85710.1 tpe 35122 35373 + ParD antitoxin protein Loose gnl|BL_ORD_ID|2306|hsp_num:0 tetB(46) 33.33 3004033 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MSRLTIDMTDQQHQSLKALAALQGKTIKQYALERLFPGDADADQAWQELKTMLGNRINDGLAGKVSTKSVGEILDEELSGDRA TPA_BN000925.1 CAJ85711.1 tpe 35370 35681 + ParE toxin Loose gnl|BL_ORD_ID|1226|hsp_num:0 APH(3')-IIIa 32.43 3002647 aminoglycoside antibiotic antibiotic inactivation APH(3') neomycin; amikacin; ribostamycin; butirosin; kanamycin A; isepamicin; gentamicin B; paromomycin; lividomycin; gentamicin MTAYILTAEAEADLRGIIRYTRREWGAAQVRRYIAKLEQGIARLAAGEGPFKDMSELFPALRMARCEHHYVFCLPRAGEPALVVAILHERMDLMTRLADRLKG TPA_BN000925.1 CAJ85713.1 tpe 36310 37482 + IS21 transposase Loose gnl|BL_ORD_ID|2415|hsp_num:0 mecD 20.75 3004185 penam antibiotic target replacement methicillin resistant PBP2 methicillin MLSREDFYMIKQMRQQGAYIVDIATQIGCSERTVRRYLKYPEPPARKTRHKMVKLKPFMDYIDMRLAENVWNSEVIFAEIKAMGYTGGRSMLRYYIQPKRKMRPSKRTVRFETQPRYQLQHDWGEVEVEVAGQRCKVNFAVNTLGFSRRFHVFAAPKQDAEHTYESLVRAFRYFGGCVKTVLVDNQKAAVLKNNNGKVVFNSGFLLLADHYNFLPRACRPRRARTKGKVERMVKYLKENFFVRYRRFDSFTHVNQQLEQWIADVADKRELRQFKETPEQRFALEQEHLQPLPDTDFDTSYFDIRHVSWDSYIEVGGNRYSVPEALCGQPVSIRISLDDELRIYSNEKLVASHRLCSASSGWQTVPEHHAPLWQQVSQVEHRPLSAYEELL TPA_BN000925.1 CAJ85714.1 tpe 36334 37482 + IS21 transposase Loose gnl|BL_ORD_ID|2415|hsp_num:0 mecD 20.75 3004185 penam antibiotic target replacement methicillin resistant PBP2 methicillin MIKQMRQQGAYIVDIATQIGCSERTVRRYLKYPEPPARKTRHKMVKLKPFMDYIDMRLAENVWNSEVIFAEIKAMGYTGGRSMLRYYIQPKRKMRPSKRTVRFETQPRYQLQHDWGEVEVEVAGQRCKVNFAVNTLGFSRRFHVFAAPKQDAEHTYESLVRAFRYFGGCVKTVLVDNQKAAVLKNNNGKVVFNSGFLLLADHYNFLPRACRPRRARTKGKVERMVKYLKENFFVRYRRFDSFTHVNQQLEQWIADVADKRELRQFKETPEQRFALEQEHLQPLPDTDFDTSYFDIRHVSWDSYIEVGGNRYSVPEALCGQPVSIRISLDDELRIYSNEKLVASHRLCSASSGWQTVPEHHAPLWQQVSQVEHRPLSAYEELL TPA_BN000925.1 CAJ85715.1 tpe 37482 38279 + IstB transposition protein Loose gnl|BL_ORD_ID|1382|hsp_num:0 OXA-209 29.27 3001809 penam antibiotic inactivation OXA beta-lactamase oxacillin MHELEVLLSRLKMEHLSYHVESLLEQAAKKELNYREFLCMALQQEWNGRHQRGMESRLKQARLPWVKTLEQFDFTFQPGIDRKVVRELAGLAFVERSENVILLGPPGVGKTHLAIALGVKAVDAGHRVLFMPLDRLIATLMKAKQENRLERQLQQLSYARVLILDEIGYLPMNREEASLFFRLLNRRYEKASIILTSNKGFADWGEMFGDHVLATAILDRLLHHSTTLNIKGESYRLKEKRKAGVLTKNTTPISDDEMVKSGQHQ TPA_BN000925.1 CAJ85716.1 tpe 38758 39531 + aminoglycoside 3'-phospho-transferase Strict gnl|BL_ORD_ID|771|hsp_num:0 APH(3')-Ib 99.61 3002642 aminoglycoside antibiotic antibiotic inactivation APH(3') neomycin; ribostamycin; kanamycin A; gentamicin B; paromomycin; lividomycin; gentamicin MPESMAAHVMGYKWARDKVGQSGCAVYRLHSKSGGSDLFLKHGKDAFADDVTDEMVRLRWLAGHISVPSVVSFVRTPNQAWLLTTAIHGKTAYQVLKSDFGARLVVVDALAAFMRRLHAIPVSECSVQQWTTHAGLPERGSIEAGVVDVDDFDKEREGWTAEQVWEAMHRLLPLAPDPVVTHGDFSLDNLLIVEGKVVGCIDVGRAGIADRYQDLAVLWNCLEEFEPSLQERLVAQYGIADPDRRKLQFHLLLDELF TPA_BN000925.1 CAJ85717.1 tpe 39615 39905 - TraA protein Loose gnl|BL_ORD_ID|300|hsp_num:0 FEZ-1 47.06 3000606 carbapenem; cephalosporin; penam antibiotic inactivation FEZ beta-lactamase MNIEAYPHDFRGSLAVVSATGVAGCRTWTLRSVETGKHYELAPASIEGWPLPAKREDSRPNSIIVNYDGNDVIALELATGELYRTRAPATTLRLRR TPA_BN000925.1 CAJ85718.1 tpe 39913 40353 - TraB protein Loose gnl|BL_ORD_ID|4992|hsp_num:0 Clostridioides difficile nimB 31.71 3007671 nitroimidazole antibiotic antibiotic inactivation nitroimidazole reductase metronidazole MNKVQIGAPRTSASPGVIMKPEGSVKIAVMNGSRQVDQVVNGEWLTMKVLPEAGLPKGIHQLSDAKDASKNVHPHKHVGQVLHDDGRNVYQFSEGGIVKHSRGIFEKPPVVGKNYEIAYSRGQGKVIGEVSQEQAAKAEQKRSRSI TPA_BN000925.1 CAJ85719.1 tpe 40369 43554 - TraC DNA primase and ssDNA binding protein Loose gnl|BL_ORD_ID|3023|hsp_num:0 OXA-570 27.69 3005324 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-60-like beta-lactamase oxacillin MAEVKKPFHEQVAERLIEQLKAGTAPWQKPWEPGMPGSFIPLNPTTGKRYKGINAIQLMAQGHADPRWMTYKQAAAAGAQVRRGEKGTPIQYWKFSEEQTKTDEQTGKPVLDANGDPVKVTVQLERPRVFFATVFNAEQIDGLPPLERKEQTWSAVERAEHILAASGATIRHGEHDRAFYRPSTDSIHLPDKGQFPSADNYYATALHELGHWTGHPSRLDRDLAHPFGSEGYAKEELRAEIASMILGDELGIGHDPGQHAAYVGSWIKALQEDPLEIFRAAADAEKIQDFVLAFEQKQIQEQTTQQAIEPAQGATMEQQQDQVARPAIAPADELIAQTLRMYRAGAEPAEGNQSLAALTETTLGFELPADWTGRVQVQANVEVEHDGERSVVPAGDREPEFWGVYANHAWGGHQWLADFAGPDAQTNAEALADRLAVIDAYATANEYEQAAKFARIHEERVRRDPNSTDEDRVAAKEARKAAEGTAMLHDEDLQRRIADYEREQQEMAQAMNAAEQPAAAQAPAKPERAYLNVPFKEKDEVKALGARWDRQERAWYVPAGVDPAPFAKWAREGATAAVEARAEAQPTQPTAERPNAAQERVYLAVPYGERQVAKAAGAQWDKVAKSWYAGPNADMGKLQRWLPDNVPTQQSPAVTPEDEFAEALKSMGCVVTPGGEHPIMDGKKHRIETEGDKKGEKSGFYVGHLDGHPAGYIKNNRTGVEMKWKAKGYALDPAEKAKMQAEAAAKLAARAEEQERQHEATAQRIGRQAQSLVPITEPTPYLRDKGLQVHAGVLTDQEGQKTYIPAYDADGKQWTMQYIQEDGTKRFAKDSRKEGCFHVVGGMDALAAAPALVIGEGYATAATVAEALGHATVAAFDSGNLQAVAEALHAKFPDKPVVIAGDDDRQVQITQGVNPGRTKAQEAAKAVGGKAIFPIFAPGENAYPKELPPITPENYRNHLHAEKRLADAAAGKVQLSEADTAKLKESLLNDGQLAALSNMKKHTDFNDLSERSSLGKDGVERQVRSAVGKVLLDEGQRQKVQQLKQQDIEQQEQRQRRARTY TPA_BN000925.1 CAJ85720.1 tpe 40369 42609 - TraC DNA primase Loose gnl|BL_ORD_ID|3023|hsp_num:0 OXA-570 27.69 3005324 carbapenem; penam antibiotic inactivation OXA beta-lactamase; OXA-60-like beta-lactamase oxacillin MEQQQDQVARPAIAPADELIAQTLRMYRAGAEPAEGNQSLAALTETTLGFELPADWTGRVQVQANVEVEHDGERSVVPAGDREPEFWGVYANHAWGGHQWLADFAGPDAQTNAEALADRLAVIDAYATANEYEQAAKFARIHEERVRRDPNSTDEDRVAAKEARKAAEGTAMLHDEDLQRRIADYEREQQEMAQAMNAAEQPAAAQAPAKPERAYLNVPFKEKDEVKALGARWDRQERAWYVPAGVDPAPFAKWAREGATAAVEARAEAQPTQPTAERPNAAQERVYLAVPYGERQVAKAAGAQWDKVAKSWYAGPNADMGKLQRWLPDNVPTQQSPAVTPEDEFAEALKSMGCVVTPGGEHPIMDGKKHRIETEGDKKGEKSGFYVGHLDGHPAGYIKNNRTGVEMKWKAKGYALDPAEKAKMQAEAAAKLAARAEEQERQHEATAQRIGRQAQSLVPITEPTPYLRDKGLQVHAGVLTDQEGQKTYIPAYDADGKQWTMQYIQEDGTKRFAKDSRKEGCFHVVGGMDALAAAPALVIGEGYATAATVAEALGHATVAAFDSGNLQAVAEALHAKFPDKPVVIAGDDDRQVQITQGVNPGRTKAQEAAKAVGGKAIFPIFAPGENAYPKELPPITPENYRNHLHAEKRLADAAAGKVQLSEADTAKLKESLLNDGQLAALSNMKKHTDFNDLSERSSLGKDGVERQVRSAVGKVLLDEGQRQKVQQLKQQDIEQQEQRQRRARTY TPA_BN000925.1 CAJ85721.1 tpe 43561 43824 - TraD protein Loose gnl|BL_ORD_ID|4562|hsp_num:0 RSA2-1 44.83 3006981 carbapenem antibiotic inactivation RSA2 beta-lactamase MNDPKTVQQDDFAPFDDTANAAAALREKLADAMTPGFQVEFDPEEAEKAGAFPEDALSEQDAAESDIDLVDATVPEDTTTAAANDGR TPA_BN000925.1 CAJ85722.1 tpe 43830 46043 - TraE putative helicase Loose gnl|BL_ORD_ID|715|hsp_num:0 CARB-9 23.47 3002248 penam antibiotic inactivation CARB beta-lactamase MQFERLVIAEKPELAKAIVEGLGGGSRKDGYYECGSDRVTWCYGHMLALLDPEDYDERYANWNMADLPIVHIPWRKKPSGDAGAKAQFKTILSLLKQAKSVVHAGDPDDEGQLLVDEILEYANCRLPVQRLLINDNNVKIVRRQLAAMRDNREFAGLSAAAEARSVGDQLYGFNITRLYTLAARAKGYQGLLSVGRVQTPILGLVVRRCRENAAHQKTYYYLVNGQFEVEGIQFPARYQVADGDPVDEKGRLSNKEHAEGIAAAVSGQPARIVSVTTKAKEAAAPLPYNLLKLQMDASRKFGFKPDQVKDITQALREKHKLITYNRSDCEYLSEEQHGDAPGVLAAIAQTAPMLAAAAQRANPTIKSRAFNSSKVSAHHAIIPTESTADLSKLTDAEQKIYLLIARAYVAQFWPKHLYDQTDVLAQVGDHRFGVRSNVTTSPGWKILYKNDAGNEDLEGNADDIEQDLRKLRDGQAGTCTDAKAEQQETKPQPLYTMESLLSDLTRVAKYIRDDRLRKILIEKDKGKQGEHGGIGTPATRDSIIATLFERGYLVEKGKHIVSTPTGEELYDALPDTARFPDMTALWHEQQKAIQAGERDTLSFVNELMEYIGAEVANIKDNGLNMKIDTHPCPSCGKPLRRLKKKDKNEYFWGCTGFADGCKFACDDKGGKPVPREAPKVSELHKCMACGHGLSRRPGKKRGMFWWGCSNFPTCKQTYPDLKGRPDYSKGRNGTNQE TPA_BN000925.1 CAJ85723.1 tpe 46058 46591 - TraF protein Loose gnl|BL_ORD_ID|4722|hsp_num:0 salE 28.57 3007029 lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; pleuromutilin antibiotic antibiotic target protection sal-type ABC-F protein tiamulin; retapamulin MSRFQRLTKYVAIGGGAALLLAGAAYLAGAKVNTTKSIPVGLYWKSNAPVEKGAYVMFCPPQVGVFSDAKERGYIAGGFCPGDYGYMMKRVLAAKGDEVAITDAGVRVNGGLLPHSALIKADPSGRPLPRYQSDSYTLGTAEVLLMSDVSDTSFDGRYFGPVNRSQIITVIRPVLTW TPA_BN000925.1 CAJ85724.1 tpe 46588 48495 - TraG protein Loose gnl|BL_ORD_ID|2306|hsp_num:0 tetB(46) 35.14 3004033 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MKNRNNAVGPQIRAKKPKASKTVPILAGLSLGAGLQTATQYFAHSFQYQAGLGWNINHVYTPWSILQWAGKWYGQYPDDFMRAASMGMVVSTVGLLGTAVTQMVKANTGKANDYLHGSARWADKKDIQAAGLLPRPRTVVELVSGKHPPTSSGVYVGGWQDKDGKFHYLRHNGPEHVLTYAPTRSGKGVGLVVPTLLSWAHSAVITDLKGELWALTAGWRKKHARNKVVRFEPASAQGSACWNPLDEIRLGTEYEVGDVQNLATLIVDPDGKGLESHWQKTSQALLVGVILHALYKAKNEGTPATLPSVDGMLADPNRDVGELWMEMTTYGHVDGQNHPAVGSAARDMMDRPEEESGSVLSTAKSYLALYRDPVVARNVSKSDFRIKQLMHHDDPVSLFIVTQPNDKARLRPLVRVMVNMIVRLLADKMDFENGRPVAHYKHRLLMMLDEFPSLGKLEILQESLAFVAGYGIKCYLICQDINQLKSRETGYGHDESITSNCHVQNAYPPNRVETAEHLSKLTGTTTIVKEQITTSGRRTSALLGNVSRTFQEVQRPLLTPDECLRMPGPKKSADGSIEEAGDMVVYVAGYPAIYGKQPLYFKDPIFQARAAVPAPKVSDKLIQTATVEEGEGITI TPA_BN000925.1 CAJ85726.1 tpe 48791 49150 - TraH protein Loose gnl|BL_ORD_ID|4825|hsp_num:0 Streptomyces venezuelae rox 32.31 3007209 rifamycin antibiotic antibiotic inactivation rifampin monooxygenase rifampin; rifaximin; rifapentine MSNPNEMTDEEIAAAMEAFDLPQPEPPSTPQAATATDGTLAPSAPAEPSHSASPTLDALDESRRPKAKTVCERCPNSVWFASPAELKCYCRVMFLVTWSSKEPNQLTHCDGEFLGQEEG TPA_BN000925.1 CAJ85728.1 tpe 50725 51096 - TraJ oriT recognising protein Loose gnl|BL_ORD_ID|146|hsp_num:0 tet(45) 37.5 3003196 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MADETKPTRKGSPPIKVYCLPDERRAIEEKAAAAGMSLSAYLLAVGQGYKITGVVDYEHVRELARINGDLGRLGGLLKLWLTDDPRTARFGDATILALLAKIEEKQDELGKVMMGVVRPRAEP TPA_BN000925.1 CAJ85729.1 tpe 51464 51868 + TraK oriT binding protein Loose gnl|BL_ORD_ID|3408|hsp_num:0 CRH-3 25.26 3006867 carbapenem antibiotic inactivation CRH beta-lactamase MPKSYTDELAEWVESRAAKKRRRDEAAVAFLAVRADVEAALASGYALVTIWEHMRETGKVKFSYETFRSHARRHIKAKPADVPAPQAKAAEPAPAPKTPEPRRPKQGGKAEKPAPAAAPTGFTFNPTPDKKDLL TPA_BN000925.1 CAJ85730.1 tpe 51868 52593 + TraL protein Loose gnl|BL_ORD_ID|3363|hsp_num:0 CARB-54 34.04 3005588 penam antibiotic inactivation CARB beta-lactamase MAKIHMVLQGKGGVGKSAIAAIIAQYKMDKGQTPLCIDTDPVNATFEGYKALNVRRLNIMAGDEINSRNFDTLVELIAPTKDDVVIDNGASSFVPLSHYLISNQVPALLQEMGHELVIHTVVTGGQALLDTVSGFAQLASQFPAEALFVVWLNPYWGPIEHEGKSFEQMKAYTANKARVSSIIQIPALKEETYGRDFSDMLQERLTFDQALADESLTIMTRQRLKIVRRGLFEQLDAAAVL TPA_BN000925.1 CAJ85731.1 tpe 52590 53027 + TraM protein Loose gnl|BL_ORD_ID|4544|hsp_num:0 PER-8 45.16 3003184 monobactam; carbapenem; cephalosporin; penam; penem antibiotic inactivation PER beta-lactamase MSDQIEELIREIAAKHGIAVGRDDPVLILHTINARLMADSAAKQEEILAAFKEELEGIAHRWGEDAKAKAERMLNAALAASKDAMAKVMKDSAAQAAEAIRREIDDGLGRQLAAKVADARRVAMMNMIAGGMVLFAAALVVWASL TPA_BN000925.1 CAJ85732.1 tpe 53079 54425 - KfrC protein Loose gnl|BL_ORD_ID|2309|hsp_num:0 OpmB 48.28 3004072 macrolide antibiotic; monobactam; tetracycline antibiotic; aminocoumarin antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; tetracycline; novobiocin; aztreonam; kitasamycin; rokitamycin MSSYSRAERAPWGDFPKVVRNGDLGSLTNEPEYQAAKQGDAEAALNLVERLISDDTVAQLKTLIGDDKPRIVPVLAVEAAGNNKIPAMMAVVLADRLGLEVETDIVQREKVARTGAGSDHRLAFNPTFEGEVIPGQKYIVVDDTLTMGGTIASLRGYIENNGGKVMAASVMTAHEGALDLAVKPKMLAGINEKHGPAMDAFWKETFGYGIDRLTQGEAGHLRAAPSVDAIRDRIAAARNEAVNRVGASRTATTARAGQQQSPAVKQSSGNSGEDLLQAAQEAETEQQALLESAPIEQTYQQTLALYVQAKHDQVERIEDRLEQLVDRQQARLQQLQSNAPGLLSLPRTKAAWQQQQAQQQARLQTLHTRLDMVREIKEGMGIHAPKIEELATRKMRAEHPELAGDWDSMREAARRHQALMRKQEQEKKQAQERERGRSQSLGLSNKPS TPA_BN000925.1 CAJ85733.1 tpe 54454 54801 - KfrB protein Loose gnl|BL_ORD_ID|1319|hsp_num:0 CARB-7 33.33 3002246 penam antibiotic inactivation CARB beta-lactamase MKHRLLVMNGQRIVQTENQGAWTNQKVDKAGALKPGIYNIYMAQKADKSQRHDGSIVHADSGSIYQQVGKNFVMHARSDFDKVPEIGSAKSITYDASGKAQVSAESVKLSRGRTR TPA_BN000925.1 CAJ85734.1 tpe 54960 55886 - KfrA coiled-coil protein Loose gnl|BL_ORD_ID|3110|hsp_num:0 ACT-63 30.0 3006258 carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation ACT beta-lactamase MELNKETRDRIFAAADELFEQGDRENFPTVDAVRKAARVNMNDASAGMREWRRQRTAQAAPLAVQVPDAVQQAGNQAVAALWQAAQALANESLQAAQAGWDRERNELEAVRGELADAFEAQARELEEAQARVTLLEQQAAEAAELAARQRQALAEARTALAGAEQRAALATQRADEVERRAQELRAELDYAHQDARAFKEESRKTLDAANQEMQALRGERDATRREAESLRTELAAVKAKAQADAEAHQEQRKLAAQEAARQAERFTTVQAERDEARQEAKAAQEEAAMLRGRLDAETSGRKHKAGGK TPA_BN000925.1 CAJ85735.1 tpe 56072 56599 - KorG Loose gnl|BL_ORD_ID|2690|hsp_num:0 tet(49) 53.57 3004582 tetracycline antibiotic antibiotic inactivation tetracycline inactivation enzyme tetracycline; oxytetracycline MTDEQKKRLLMLQAIRRSIQAMRRGVSGPDSFKGWLTGIGIIAAGFLVGELLPSPAPGVGLVVPGACIAGFVVGCWLNRKGRSWPTAIYDQLARYQPLNERAYRDLQETVKERGLDCDAVMEWTYIEQAEFMPLVPTREDLARDKFLTATRADRAEDDARARFVVLHPKKRGPDA TPA_BN000925.1 CAJ85736.1 tpe 56592 57113 - KorF repressor protein Loose gnl|BL_ORD_ID|888|hsp_num:0 otr(B) 34.29 3002892 tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump tetracycline MNPMLFYIAGGVGAALLLVSAIMLFKLREPKKEHRPQRKAAAPTPQPVDNELLRTFRRPSQASQPEPSTTPPARRTAPPSSEQSRGNDGDFVTSALVAGGDQQHHAGLPGRRLADRGHAGRCAAAGYAVCGVRGPLAVLRQQRHGQRLDRYRQLLRFQFVRHRYEQLVRADHD TPA_BN000925.1 CAJ85737.1 tpe 57184 58260 - KorB partitioning and repressor protein Loose gnl|BL_ORD_ID|2681|hsp_num:0 NDM-21 28.87 3004864 carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation NDM beta-lactamase MTAAQAKTTKKNTAAAAQEAAGAAQPSGLGLDSIGDLSSLLDAPAASQGGSGPIELDLDLIDEDPHQPRTADNPGFSPESIAEIGATIKERGVKSPISVRENQEQPGRYIINHGARRYRGSKWAGKKSIPAFIDNDYNEADQVIENLQRNELTPREIADFIGRELAKGKKKGDIAKEIGKSPAFITQHVTLLDLPEKIADAFNTGRVRDVTVVNELVTAFKKRPEEVEAWLDDDTQEITRGTVKLLREFLDEKGRDPNTVDAFNGQTDAERDAEAGDGQDGEDGDQDGKDAKEKGAKEPDPDKLKKAIVQVEHDERPARLILNRRPPAEGYAWLKYEDDGQEFEANLADVKLVALIEG TPA_BN000925.1 CAJ85740.1 tpe 59033 59338 - KorA repressor protein Loose gnl|BL_ORD_ID|926|hsp_num:0 OXA-18 27.66 3001413 penam antibiotic inactivation OXA beta-lactamase oxacillin MKKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDKNLPEGYARVTAVLPEHQAYIVRKWEADAKKKQETKR TPA_BR000038.1 FAA00024.1 tpd 1 288 - putative transcriptional repressor Loose gnl|BL_ORD_ID|1143|hsp_num:0 H-NS 29.73 3000676 macrolide antibiotic; fluoroquinolone antibiotic; cephalosporin; cephamycin; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; cloxacillin; ciprofloxacin; tetracycline; oxacillin; norfloxacin MNDLKNMSADELRAQRAQIDAELKKREAKERQEARKKILEIANTHGINIAELASKERQYRNPDDQWETWNGRGRKPKWVKEWLAKGHSLEELEVS TPA_BR000038.1 FAA00025.1 tpd 425 1018 + hypothetical protein Loose gnl|BL_ORD_ID|3572|hsp_num:0 GOB-34 47.37 3005683 carbapenem; cephalosporin; penam antibiotic inactivation GOB beta-lactamase MNRKMTVVSASLVGALSLFSQTAKADDWGCQVLLCLSDPRGPTTESECKPPIHKLWDHLRKGKPFPSCAMATNSRTGKRSYAQLVYDPYDPCPDGTKPAGGYIAQSQSADRKDWRRLQYAFSTHGRRYDSGGAWNMYEGNGPRACVGNHLGSYSVYRGNDDSNISVQVYDQVVWQQPQNPRAIDVFIDEAFHHRVRY TPA_BR000038.1 FAA00026.1 tpd 1020 1616 + TrwN protein Loose gnl|BL_ORD_ID|3555|hsp_num:0 GIL-1 46.67 3006888 carbapenem; cephalosporin antibiotic inactivation GIL beta-lactamase MALAEFAVIAAMCAPAIHPTTLSAVVTQESRGNIYAIGINGDHKLPRQPQTLEEAIATAEQLRRDGYNFDAGLGQINIKNLEWLGMSIADLFDPCKNLKGAQTVLLDCYERAVPRYGDGQGALQAALSCYNTGNFQRGFSNGYVQKVASHVGVTVPALEPVSGGTQEPAKLQAVPKGAARLAPAQTKPRARACRCLLS TPA_BR000038.1 FAA00027.1 tpd 1841 2137 + putative transcriptional repressor Loose gnl|BL_ORD_ID|214|hsp_num:0 ACT-19 29.23 3001840 carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation ACT beta-lactamase MRAIEQQSVDKAFSQRAVREVTVVKRSEKEWYFTFVADDPVTKKPVTYSLLTQRGKLRTWADPRHLFNFLRERGVTHGNFNLDEENKHEEPELPPGES TPA_BR000038.1 FAA00028.1 tpd 2070 2408 + TrwL protein Loose gnl|BL_ORD_ID|3521|hsp_num:0 ECM-1 33.33 3006882 carbapenem antibiotic inactivation ECM beta-lactamase MATSILTRKTNMKNLNYLRAKANGKLAAIFGAIAAMLTAQPAAAQGLEKARSVLETLQQELTTIVPIAAAVILLCLGIAYAGRFIEKDTFVRWSIGVIIAGSAVQITAMLFT TPA_BR000038.1 FAA00029.1 tpd 2421 2735 + TrwM protein Loose gnl|BL_ORD_ID|4970|hsp_num:0 mef(C) 29.73 3003745 macrolide antibiotic; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump oxytetracycline MKPPQQQHEAFPLFKGATRLPTILGEPMIPLMAMVMGVAVIALTVSIWWWALVPPLWFIMAQITKNDDKAFRIWWLWIDTKFRNRNKGFWGASSYSPANYRKRR TPA_BR000038.1 FAA00030.1 tpd 2738 5209 + TrwK protein Loose gnl|BL_ORD_ID|2740|hsp_num:0 IDC-1 37.5 3005012 carbapenem; cephalosporin antibiotic inactivation IDC beta-lactamase MGAIESRKLLASETPVGQFIPYSHHVTDTIISTKNAEYLSVWKIDGRSHQSASEADVFQWIRELNNTLRGISSANLSLWTHIVRRRVYEYPDAEFDNVFCRQLDEKYRESFTGYNLMVNDLYLTVVYRPVSDKVLSFFAKRERETPDQKKHRQESCIKALEDINRTLGQSFKRYGAELLSVYEKGGHAFSAPLEFLARLVNGEHIPMPICRDRFSDYMAVNRPMFSKWGEVGELRSLTGLRRFGMLEIREYDDATEPGQLNVLLESDYEFVLTHSFSVLSRPAAKEYLQRHQKNLIDARDVATDQIEEIDEALNQLISGHFVMGEHHCTLTVYGETVQQVRDNLAHASAAMLDVAVLPKPVDLALEAGYWAQLPANWQWRPRPAPITSLNFLSFSPFHNFMSGKPTGNPWGPAVTILKTVSGTPLYFNFHASKEEEDATDKRLLGNTMLIGQSSSGKTVLLGFLLAQAQKFKPTIVAFDKDRGMEISIRAMGGRYLPLKTGEPSGFNPFHAPADARKPDFPQTVREEARGCRWRGHAPGRGRNRPGHYAMMSDSIDKSLRRLSLLLQFLPNPRSDDMDARPTVHARLVKWCEGGDYGWLFDNPTDALDLSTHQIYGFDITEFLDNPEARTPVMMYLLYRTESMIDGRRFMYVFDEFWKPLQDEYFEDLAKNKQKTIRKQNGIFVFATQEPSDALESNIAKTLIQQCATYIFLANPKADYEDYTQGFKLTDSEFELVRGLGEFSRRFLIKQGDQSALAEMNLGKFRTIVDGETVERDFDDELLVLSGTPDNAEIAESIIAEVGDSPAVWLPIFLDRVKAERSDV TPA_BR000038.1 FAA00031.1 tpd 5206 5886 + TrwJ protein Loose gnl|BL_ORD_ID|2377|hsp_num:0 lnuG 33.33 3004085 lincosamide antibiotic antibiotic inactivation lincosamide nucleotidyltransferase (LNU) lincomycin MKKLVMTAAVAAILGAASPVMAQGIPVFDGTRALDFVQQFARMKEQLDTAKDQLAEAQRMYEAVTGGRGLGDLMRNAQLREYLPDDLRTVYDSANGGGYSGISGSINDILRDERLNGSVADMRRSIEERSRTARTTDKAVGCGPTKGHSNASRRLKDEISRTQDQKAIEELQARIAGEQAAIQNETTKLQMIAQLRQAEQALISEQRRERNMPILSSGNQGMPTIQ TPA_BR000038.1 FAA00032.1 tpd 5883 6113 + entry exclusion protein Loose gnl|BL_ORD_ID|670|hsp_num:0 PC1 beta-lactamase (blaZ) 34.78 3000621 penam antibiotic inactivation BlaZ beta-lactamase MKKILVPLLMVSALSACKDEPTHDVQYYLDNPKERTEKIAECKNNPGEKALAANCVNATEAQRKAMFQGDGMPKIR TPA_BR000038.1 FAA00034.1 tpd 7269 7412 + TrwH protein Loose gnl|BL_ORD_ID|1679|hsp_num:0 bacA 39.13 3002986 peptide antibiotic antibiotic target alteration undecaprenyl pyrophosphate related proteins bacitracin; bacitracin A; bacitracin B; bacitracin F MKTIIFAILMTGLLSACASAPKPKQPSDFNREPVNKTVPVEIQRGAL TPA_BR000038.1 FAA00035.1 tpd 7409 8104 + TrwG protein Loose gnl|BL_ORD_ID|949|hsp_num:0 APH(6)-Id 34.78 3002660 aminoglycoside antibiotic antibiotic inactivation APH(6) streptomycin MSKKQPKPVKAEQLKSYYEESRGLERDLIGEFVKSRKTAWRVATASGLFGLLGMVCGIVGFSQPAPAPLVLRVDNATGAVDVVTTLREHESSYGEVVDTYWLNQYVLNREAYDYNTIQMNYDTTALLSAPAVQQDYYKLFDGSNARDRVLGNKARITVRVRSIQPNGRGQATVRFTTQQHNSNGTVERPQHQIATIGYTYIGAPMRSSDRLLNPLGFQVTSYRADPEILNN TPA_BR000038.1 FAA00037.1 tpd 8915 10102 + TrwE protein Loose gnl|BL_ORD_ID|2015|hsp_num:0 MexV 46.15 3003030 macrolide antibiotic; fluoroquinolone antibiotic; tetracycline antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; acriflavine; tetracycline; chloramphenicol MFGRKKGDVIDAGAELERAEQERIEGEYGASELASERRPHTPGARTLLMVLLCVIAVVLVTLSYKAYKVRGVVEDDDAQPQQVVRQVIPGYTPRPIRPEPENVPEPPQPTTSVPAIQPAPVTQPVRPQPTGPREKTPYELARERMLRSGLTAGSGGGEDLPRPQGGDVPAGGLMGGGGGGGELAEKLQPMRLSGSSAGRLGNRDMLITQGTQLDCVLETRLVTTQPGMTTCHLTRDVYSTSGRVVLLDRGSKVVGFYQGGLRQGQARIFVQWSRIETPSGVVINLDSPGTGPLGEAGLGGWIDRHFWERFGGAIMISLIGDLGDWASRQGSRQGNNSIQFSNTANGVESAAAEALRNSINIPPTLYKNQGERVNILVARDLDFSDVYSLESIPTK TPA_BR000038.1 FAA00038.1 tpd 10068 11144 + TrwD protein Loose gnl|BL_ORD_ID|527|hsp_num:0 vgaA 51.72 3002829 lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; pleuromutilin antibiotic antibiotic target protection vga-type ABC-F protein clindamycin; virginiamycin M1 MSTVSKASPLSSGNRVGKDQAVAQLLRPLDRFLDAPEVTELSICRPGEVWTKTFEGWQVHEVPELTEPFLQALITAIIVYNGVAPKSVNYVVLPGGQRGTIAQAPAVIDGTLSFLIRKHSLVVKTLEELDAEGAFDTFTDVSFNKPSAEEANHYLTVQDFTRLEPFEVELLKLKRDGTIREFLEKCVLYKRNIIIAGKTGSGKTTFARSLIEKVPPEERIITIEDVHELFLPNHPNRVHMLYGYGAGRVSADECLAACMRQSPDRIFLAELRGNEAWEYLNSLNTGHPGSITTTHANNALQTFERCATLIKKSDVGRQLEMEMIKLVLYTTIDVVLFFKDRKLVEVFYDPIFSKSKMA TPA_BR000038.1 FAA00039.1 tpd 11227 14127 - TrwC protein Loose gnl|BL_ORD_ID|3966|hsp_num:0 OXA-732 28.57 3005937 penam antibiotic inactivation OXA beta-lactamase oxacillin MLSHMVLTRQDIGRAASYYEDGADDYYAKDGDASEWQGKGAEELGLSGEVDSKRFRELLAGNIGEGHRIMRSATRQDSKERIGLDLTFSAPKSVSLQALVAGDAEIIKAHDRAVARTLEQAEARAQARQKIQGKTRIETTGNLVIGKFRHETSRERDPQLHTHAVILNMTKRSDGQWRALKNDEIVKRTRYLGAVYNAELAHELQKLGYQLRYGKDGNFDLAHIDRQQIEGFSKRTEQIAEWYAARGLDPNSVSLEQKQAAKVLSRAKKTSVDREALRAEWQATAKELGIDFSRREWSGREKGGSEKQAHSFMPSDEAAKRAVRYAINHLTERQSVMDERELVDTAMKHAVGAARLEDIQKELLRQTETGYLIREAPRYRPGGQTGPTDEPGKTRAEWVAELAAKGMKQGAARERVDNAIKTGGLVPIEPRYTTQTALEREKRILQIERDGRGAVAPVIAAEAARERLASTNLNQGQREAAELIVSAANRVVGVQGFAGTGKSHMLDTAKQMIEGEGYHVRALAAYGSQVKALRELNVEANTLASFLRAKDKNIDSRTVLVIDEAGVVPTRLMEQTLKLAEKAGARVVLMGDTAQTKAIEAGRPFDQLQAAGMQTAHMREIQRQKNPELKIAVELAAAGKASSSLERIKDVTEIKNHHERRAAVAEAYIALKPDERDRTLIVSGTNEARREINQIVREGLGTAGKGIEFDTLVRVDTTQAERRHSKNYQVGHVIQPERDYAKTGLQRGELYRVVETGPGNRLTVIGEHDGQRIQFSPMTHTKISVYQPERAELAVGDTIRITRNDKHLDLANGDRMKVVAVEDRKVTVTDGKRNVELPTDKPLHVDHAYATTVHSSQGLTSDRVLIDAHAESRTTRKDVYYVAISRARFEARVFTNDRGKLPAAIARENIKSAAHDLARDRGGRSAAAERQREQQRERERNRQTQQPAHDRQKAAREAERGMEAGR TPA_BR000038.1 FAA00040.1 tpd 14127 15650 - TrwB protein Loose gnl|BL_ORD_ID|2307|hsp_num:0 tetA(60) 35.0 3004035 tetracycline antibiotic antibiotic efflux ATP-binding cassette (ABC) antibiotic efflux pump tetracycline MHPDDQRKVSAGIVIVLPLIFWITAVQKTEVLGSPKLLALWELMKLTPQKPILLLSALGGLAVGVLFVWLLNSVGQGEFGGAPFKRFLRGTRIVSGGKLKRMTREKAKQVTVAGVPMPRDAEPRHLLVNGATGTGKSVLLRELAYTGLLRGDRMVIVDPNGDMLSKFGRDKDIILNPYDQRTKGWSFFNEIRNDYDWQRYALSVVPRGKTDEAEEWASYGRLLLRETAKKLALIGTPSMRELFHWTTIATFDDLRGFLEGTLAESLFAGSNEASKALTSARFVLSDKLPEHVTMPDGDFSIRSWLEDPNGGNLFITWREDMGPALRPLISAWVDVVCTSILSLPEEPKRRLWLFIDELASLEKLASLADALTKGRKAGLRVVAGLQSTSQLDDVYGVKEAQTLRASFRSLVVLGGSRTDPKTNEDMSLSLGEHEVERDRYSKNTGKHHSTGRALERVRERVVMPAEIANLPDLTAYVGFAGNRPIAKVPLEIKQFANRQPAFVEGTI TPA_BR000038.1 FAA00041.1 tpd 15652 16017 - TrwA protein Loose gnl|BL_ORD_ID|2395|hsp_num:0 FosA7 40.0 3004113 phosphonic acid antibiotic antibiotic inactivation fosfomycin thiol transferase fosfomycin MALGDPIQVRLSPEKQALLEDEAARKGKRLATYLRELLESENDLQGELAALRREVVSLHHVIEDLADTGLRSDQSGPGQNAVQIETLLLLRAIAGPERMKPVKGELKRLGIEVWTPEGKED TPA_BR000038.1 FAA00042.1 tpd 16471 16896 + hypothetical protein Loose gnl|BL_ORD_ID|1267|hsp_num:0 mdsB 37.25 3000790 monobactam; carbapenem; cephalosporin; cephamycin; penam; phenicol antibiotic; penem antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump chloramphenicol MNETDALKDRIENIRPRMTLAAKLRELMPEIDRQVRAGVQHDDIVETLNANGFDVNLNTFRSYLYRYRKKARASEGQPEPAQATPKADGNSPVVSGGPGDVSPDFDADSLADALDARKRDELGDKYLGLKRHIFSKRSDNK TPA_BR000038.1 FAA00044.1 tpd 17602 17988 + hypothetical protein Loose gnl|BL_ORD_ID|550|hsp_num:0 mdtG 43.24 3001329 phosphonic acid antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump fosfomycin MAGPQTTREALIAELLGDVGVLIDKTDELRASFPAAADEAAAKVKAAGQRATEDVATAATQLTRDLATQTEKLLQGVQQAAREAQAAARVVDRSARRFALLATAMGLAAGIVGGVLAGLALSGYSFGA TPA_BR000038.1 FAA00045.1 tpd 18142 18393 - hypothetical prootein Loose gnl|BL_ORD_ID|4136|hsp_num:0 OXA-921 32.35 3006107 cephalosporin; penam antibiotic inactivation OXA beta-lactamase; OXA-1-like beta-lactamase oxacillin MTNEHTAPVLFYFDKAETLREFEAFRVEASQITRPHQIPAQVEVWNVIGKRRFIDRQEVIAEFPNELYAQIFADMADKTAAHI TPA_BR000038.1 FAA00046.1 tpd 18541 19194 - hypothetical protein Loose gnl|BL_ORD_ID|2002|hsp_num:0 TriC 25.27 3003681 disinfecting agents and antiseptics antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump triclosan MSRKHQPKTERQEKAAVIAASLPEDRGELMDAAAEAIRQYDAAIVGCDDDAAHAARDRYEAVIWKLNGNSFFGTKADADSPGYQVERHCAATPGTVPLWGQKGEFLMTVEGIRAVVEFGNGYGSMYAHFAFHAVDLDLPFISETGYRSHFTPVMGGMTVDEAAEAIMRAILAEKGRVLIKPDSRQFYEGREARAWLDYTRPAQTIYQEGNGQIAFGF TPA_BR000038.1 FAA00047.1 tpd 19210 19554 - hypothetical protein Loose gnl|BL_ORD_ID|4795|hsp_num:0 tet(X1) 32.35 3005166 tetracycline antibiotic antibiotic inactivation tetracycline inactivation enzyme tetracycline; minocycline; oxytetracycline MLVLTTEGRKRRQPPGQINAGVKAMKRKFRLGQMLATIGVLELCKHKHIDLGPLIDRHVSGDWGDVDDAQREANEEAVKECGTIVSVYHPHGVRVLIVTDGDRSHTVAMLPHEY TPA_BR000038.1 FAA00048.1 tpd 20139 20207 - hypothetical protein Loose gnl|BL_ORD_ID|1745|hsp_num:0 AAC(6')-Iih 85.71 3002590 aminoglycoside antibiotic antibiotic inactivation AAC(6') dibekacin; amikacin; sisomicin; netilmicin; tobramycin; 2'-N-ethylnetilmicin; 5-episisomicin MSLRFASGRALFRLTWPPLRSG TPA_BR000038.1 FAA00049.1 tpd 20247 20570 - hypothetical protein Loose gnl|BL_ORD_ID|935|hsp_num:0 evgA 30.77 3000832 macrolide antibiotic; fluoroquinolone antibiotic; penam; tetracycline antibiotic antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump; resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; cloxacillin; tetracycline; oxacillin; norfloxacin MDENKMTAAAFDDLRPRLGRLTEETIDIAREVLVEGKSQSDVARERGLSRQRVSSMVKSVVSAANEIPREWQRVEVWLPPNLAEKVRQMEADAKADVARKNQSTDAA TPA_BR000038.1 FAA00050.1 tpd 20622 20975 - hypothetical protein Loose gnl|BL_ORD_ID|2028|hsp_num:0 MSI-1 28.85 3003718 carbapenem antibiotic inactivation MSI beta-lactamase MSNRFEAEGNLGKVSELRTVNVGGKEREVLDFSIYIERRVPDGSGGFTDKGGFWLNGSLWGGRARVTHEHLKKGMRVRTAGELRMETWEQDGEQRSGLKLDAEYVVIDPITYARRDR TPA_BR000038.1 FAA00051.1 tpd 21174 21950 - hypothetical protein Loose gnl|BL_ORD_ID|1876|hsp_num:0 TEM-60 24.49 3000929 monobactam; cephalosporin; penam; penem antibiotic inactivation TEM beta-lactamase ceftazidime; ampicillin MNSYEQKQQARRARYEARADQASQEADATYSKARTMAEAIPFGQPILIGHHSEGRDRRYRARIHDTFGKSFALQDKAKHYAAKAAAVGTGGISSDDPDAIEKLRAELASVREAQDRMKAANRLIRKNDRPGLAELGFTPDEIEALFTPDFCGRVGFPAYALSNNNANARRIEKRIKELEAMRERPDVEHEGNGYTYREDTTENRVMFIFTGKPDAETRQLLKRHAFKWSPSRNAWVRQLTNAGIFAAKQVRATLDATA TPA_BR000038.1 FAA00052.1 tpd 22018 22182 - hypothetical protein Loose gnl|BL_ORD_ID|1471|hsp_num:0 ErmR 44.44 3000594 macrolide antibiotic; lincosamide antibiotic; streptogramin antibiotic; streptogramin A antibiotic; streptogramin B antibiotic antibiotic target alteration Erm 23S ribosomal RNA methyltransferase erythromycin; roxithromycin; lincomycin; telithromycin; clarithromycin; clindamycin; tylosin; spiramycin; azithromycin; dirithromycin; pristinamycin IA; quinupristin; virginiamycin M1; madumycin II; griseoviridin; dalfopristin; pristinamycin IB; virginiamycin S2; pristinamycin IC; vernamycin C; patricin A; patricin B; ostreogrycin B3; oleandomycin MQLPKTIIWKGNEYEVPDMAEIENFVFDSVCETPDGETVEPDHPDSWLSLIGLI TPA_BR000038.1 FAA00053.1 tpd 22255 22533 - hypothetical protein Loose gnl|BL_ORD_ID|741|hsp_num:0 mecC 39.13 3001209 penam antibiotic target replacement methicillin resistant PBP2 methicillin MLTAIDKTPVLHHNCIMVASLNDGGNMQVRVIVGAQAAYACISHESGTLDVRLNPGRSARKSMKESAAELREKAAELTRRAALIENAAELVD TPA_BR000038.1 FAA00054.1 tpd 22591 23547 - ArdC protein Loose gnl|BL_ORD_ID|973|hsp_num:0 CTX-M-141 28.57 3001999 cephalosporin antibiotic inactivation CTX-M beta-lactamase MTRNKAAATAPGFGTLAGVETMNAKTKFDLYQHVTDRIIASIEAGTPAWRKPWTGEAATMQMPLRSNGEAYRGINVVMLWLTAAEKGYRSAYWFTYRQAKELGGQVRKGEKGSTVVKFGTIEREDEQTGEEKKIPYLKGYTVFNADQIDGLPEQYHAAPAEAARDLGTAADPELDAFFAATGADIRTSSEPRAYYNPTGDYIHMPPIATFHSAAGYYATLAHEATHWTGHKSRLDRFSRFSDRKSYAFEELIAEIGNCMLCASLGLIPDFDQSAAYVQSWLRALKDDKRLIFKAATEAQKAADLLQENAANFQRKEAA TPA_BR000038.1 FAA00055.1 tpd 24145 24213 - hypothetical protein Loose gnl|BL_ORD_ID|1745|hsp_num:0 AAC(6')-Iih 85.71 3002590 aminoglycoside antibiotic antibiotic inactivation AAC(6') dibekacin; amikacin; sisomicin; netilmicin; tobramycin; 2'-N-ethylnetilmicin; 5-episisomicin MSLRFAPGRALFRLTWPPLRSG TPA_BR000038.1 FAA00056.1 tpd 24217 24780 - Osa protein Loose gnl|BL_ORD_ID|2050|hsp_num:0 ACT-38 41.94 3003655 carbapenem; cephalosporin; cephamycin; penam antibiotic inactivation ACT beta-lactamase MLLRRRCRAWLEIRRLDKELAQSSGLPLELPQIVPNAWNEVVWRLPVPNHPDAFMTASNAAQSDFIVYVNGLAFYRAWLALGVEDSQACPLKQDMPKDRKYPSSAAHFAVGIDSPVPLADVSPTMILGHFAVCFTDGMTRSMWLLAHEVAVFPVLSRDEASAVMLAEHVGVAAPIQVSKLREQCRKI TPA_BR000038.1 FAA00057.1 tpd 24789 25391 - hypothetical protein Loose gnl|BL_ORD_ID|2434|hsp_num:0 ADC-15 26.32 3003859 cephalosporin antibiotic inactivation ADC beta-lactamase without carbapenemase activity MTDTRREQEKDERRKLQEQSRQNEAETMRLLAFEAGRQLAEIPKEAKGNEPLLENYKSGLQETRKELETTPDATKSTNANRLERDVQRAIIDAQQVREAVGREKARADEFHRHAEPGETYRGRVIGRTNSYVIQADDSRPGTIILHERAAVSGAEKVKMNDHAEISYPHGRAGIVRNPQAAQHQRQRQMEKTGAGREHGR TPA_BR000038.1 FAA00058.1 tpd 25595 26119 - Nuc protein Loose gnl|BL_ORD_ID|603|hsp_num:0 vanXY gene in vanE cluster 29.41 3002967 glycopeptide antibiotic antibiotic target alteration glycopeptide resistance gene cluster; vanXY vancomycin MKSALAALRAVAAAVVLIVSVPAWADFRGEVVRILDGDTIDVLVNRQTIRVRLADIDAPESGQAFGSRARQRLADLTFRQEVQVTEKEVDRYGRTLGVVYAPLQYPGGQTQLTNINAIMVQEGMAWAYRYYGKPTDAQMYEYEKEARRQRLGLWSDPNAQEPWKWRRASKNATN TPA_BR000038.1 FAA00059.1 tpd 26116 26745 - hypothetical protein Loose gnl|BL_ORD_ID|4928|hsp_num:0 cfrE 30.43 3005023 lincosamide antibiotic; streptogramin antibiotic; oxazolidinone antibiotic; phenicol antibiotic; pleuromutilin antibiotic antibiotic target alteration Cfr 23S ribosomal RNA methyltransferase thiamphenicol; tiamulin MAITKQDIWRAADELDAEGIRPTLAAVRKKLGSGSFTTISDAMAEWKNRKTATLPSSDPLPVAVNEHLAELGNALWAIALAHANARFDEDRKQIEADKAAISQQLAEAIELADTFTRENDQLRERVNQLEPMERERDKLADQLAEVKRRSGEELNRCMEKLTQRDNEAIEARKQAKEAIERAASLQGQVEALKEQVANLTAVLKTGGKQ TPA_BR000038.1 FAA00060.1 tpd 27457 28428 - RepA protein Loose gnl|BL_ORD_ID|2025|hsp_num:0 PEDO-3 27.38 3003715 carbapenem antibiotic inactivation subclass B1 PEDO beta-lactamase MPKNNKAPGHRINEIIKTSLALEMEDAREAGLVGYMARCLVQATMPHTDPKTSYFERTNGIVTLSIMGKPSIGLPYGSMPRTLLAWICTEAVRTKDPVLNLGRSQSEFLQRLGMHTDGRYTATLRNQAQRLFSSMISLAGEQGNDFGIENVVIAKRAFLFWNPKRPEDRALWDSTLTLTGDFFEEVTRSPVPIRIDYLHALRQSPLAMDIYTWLTYRVFLLRAKGRPFVQIPWVALQAQFGSSYGSRARNSPELDDKARERAERAALASFKYNFKKRLREVLIVYPEASDCIEDDGECLRIKSTRLHVTRAPGKGARIGPPPT TPA_BR000038.1 FAA00062.1 tpd 29229 29459 - hypothetical protein Loose gnl|BL_ORD_ID|409|hsp_num:0 mtrE 50.0 3000812 macrolide antibiotic; penam antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump erythromycin; penicillin; azithromycin MFLILWWLRGPVRFLLGLASFASLITLPIMWLGLDSANKTHIMLSVAGVGLGASALMWFYDALLMRLAPEPILFST TPA_BR000038.1 FAA00063.1 tpd 29666 30679 - IntI1 integrase Loose gnl|BL_ORD_ID|1241|hsp_num:0 dfrA22 42.31 3003018 diaminopyrimidine antibiotic antibiotic target replacement trimethoprim resistant dihydrofolate reductase dfr trimethoprim MKTATAPLPPLRSVKVLDQLRERIRYLHYSLRTEQAYVNWVRAFIRFHGVRHPATLGSSEVEAFLSWLANERKVSVSTHRQALAALLFFYGKVLCTDLPWLQEIGRPRPSRRLPVVLTPDEVVRILGFLEGEHRLFAQLLYGTGMRISEGLQLRVKDLDFDHGTIIVREGKGSKDRALMLPESLAPSLREQLSRARAWWLKDQAEGRSGVALPDALERKYPRAGHSWPWFWVFAQHTHSTDPRSGVVRRHHMYDQTFQRAFKRAVEQAGITKPATPHTLRHSFATALLRSGYDIRTVQDLLGHSDVSTTMIYTHVLKVGGAGVRSPLDALPPLTSER TPA_BR000038.1 FAA00064.1 tpd 30918 31154 + dihydrofolate reductase Perfect gnl|BL_ORD_ID|1820|hsp_num:0 dfrB2 100.0 3003021 diaminopyrimidine antibiotic antibiotic target replacement trimethoprim resistant dihydrofolate reductase dfr trimethoprim MGQSSDEANAPVAGQFALPLSATFGLGDRVRKKSGAAWQGQVVGWYCTKLTPEGYAVESESHPGSVQIYPVAALERVA TPA_BR000038.1 FAA00065.1 tpd 31209 31643 + hypothetical protein Loose gnl|BL_ORD_ID|2350|hsp_num:0 MexF 72.73 3000804 fluoroquinolone antibiotic; diaminopyrimidine antibiotic; phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump ciprofloxacin; trimethoprim; chloramphenicol; norfloxacin MGQTLTIEPSGESRGHCDCCGNSSRTVWGYVQDSERTICAYFVQWTVGAPDHFPNFDFLIGTWGDDAVSDKVLSSWLFNPEAGSFMIIDASSRPAAASDMCNHALSRAEVLAAPGMKSLASQCLDAVWIQDERVAEIRGWKNDA TPA_BR000038.1 FAA00066.1 tpd 31809 32156 + QacEdelta1 Perfect gnl|BL_ORD_ID|2739|hsp_num:0 qacEdelta1 100.0 3005010 disinfecting agents and antiseptics antibiotic efflux major facilitator superfamily (MFS) antibiotic efflux pump MKGWLFLVIAIVGEVIATSALKSSEGFTKLAPSAVVIIGYGIAFYFLSLVLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSPSWKSLRRPTPW TPA_BR000038.1 FAA00067.1 tpd 32150 32989 + dehydropteroate synthase Perfect gnl|BL_ORD_ID|978|hsp_num:0 sul1 100.0 3000410 sulfonamide antibiotic antibiotic target replacement sulfonamide resistant sul sulfadiazine; sulfadimidine; sulfadoxine; sulfamethoxazole; sulfisoxazole; sulfacetamide; mafenide; sulfasalazine; sulfamethizole MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVGPAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQGFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRSGVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLPVKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA TPA_BR000038.1 FAA00068.1 tpd 33117 33617 + hypothetical protein Loose gnl|BL_ORD_ID|1202|hsp_num:0 SAT-2 31.15 3002895 nucleoside antibiotic antibiotic inactivation streptothricin acetyltransferase (SAT) streptothricin MDSEEPPNVRVACSGDIDEVVRLMHDAAAWMSAKGTPAWDVARIDRTFAETFVLRSELLVASCSDGIVGCCTLSAEDPEFWPDALKGEAAYLHKLAVRRTHAGRGVSSALIEACRHAARTQGCAKLRLDCHPNLRGLYERLGFTHVDTFNPGWDPTFIAERLELEI TPA_BR000038.1 FAA00069.1 tpd 33600 33740 - hypothetical protein Loose gnl|BL_ORD_ID|2018|hsp_num:0 mexM 37.93 3003704 phenicol antibiotic antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump chloramphenicol; thiamphenicol MMEVEDIDNLSRNQDIAVGLQVILKPRARPTPTWTSMPERTLDFEF TPA_BR000038.1 FAA00070.1 tpd 33804 33878 - hypothetical protein Loose gnl|BL_ORD_ID|4633|hsp_num:0 VIM-61 62.5 3005509 carbapenem; cephalosporin; cephamycin; penam; penem antibiotic inactivation VIM beta-lactamase MEPHRTNVIIFPKVREVAEAAEQA TPA_BK010830.1 DAC79481.1 tpg 5542 7860 - uncharacterized protein Loose gnl|BL_ORD_ID|1955|hsp_num:0 Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin 41.46 3003283 rifamycin antibiotic antibiotic target alteration; antibiotic target replacement rifamycin-resistant beta-subunit of RNA polymerase (rpoB) rifampin; rifaximin; rifabutin; rifapentine MRKRVSPEELVADIRQTADKLNQEYLTADEYDRRGEYNKSTPIDRFGSWNAAVRKAGLEVAHKAQRNSKETLLADLRRVADSLNQDHLTITEYEDKGNHGVATITRRLGSWNDALREAGLTPFQKKNIEPEDILRDLRRVADDTNGNSVIIPEYETHGDYGITTIAAKFGSWTNAVRKAGFTPATEITEEELLIDLRRIANETVGDTLLKSDYKEYGEYSPSTALRRFGTWDEVVEKVGATSGDQKIPDEDLFADLRRVADEIDRRCLTKADYDERGKYSASTITARFESWGSAVKEAGLLPVSQWYGTTEQPSWTQLGRSPNECKIAKEDLLIDLRRVANKIEGDRIKARDYDQEGKYSATTVIRQFESWVNAVEKVGYKSHIKRIATEDLKHSLQNVGSEDEVPTSTEYAENGKYHYQTVIERFGSWSNAVQAAGYTSYSPPRTSWIPSEELIASIQTLSSEDEPPTSIEYDESGKFGTATVVRRFGTWANALQEAGYTSKQIDRLLPYTDDVEDEELLRELRRLADGEVGPTTHTIKTEGDYSTTPYFDRFGTIWQSVVCAGLKPYSRTPVTKTQYVDFIETVLDYGHPTRQLTGLLLAFTGLETTLTGKFSTEWVVNLNTSEETAIRVPKEHLQSDEDWILKVPSKWHNPETNQQETTHIEGLLNWAVNHEQELYSSTSGVESFLSMVNESIGIEGSRESHLTMALGTHLAERGAPPWFIQKQTGVGFRGMDAEVEDFYLWNYVHQGINHPDYNPPDVVLNPTGRIID L533R, H526T TPA_BK010831.1 DAC79685.1 tpg 5542 7860 - uncharacterized protein Loose gnl|BL_ORD_ID|1955|hsp_num:0 Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin 41.46 3003283 rifamycin antibiotic antibiotic target alteration; antibiotic target replacement rifamycin-resistant beta-subunit of RNA polymerase (rpoB) rifampin; rifaximin; rifabutin; rifapentine MRKRVSPEELVADIRQTADKLNQEYLTADEYDRRGEYNKSTPIDRFGSWNAAVRKAGLEVAHKAQRNSKETLLADLRRVADSLNQDHLTITEYEDKGNHGVATITRRLGSWNDALREAGLTPFQKKNIEPEDILRDLRRVADDTNGNSVIIPEYETHGDYGITTIAAKFGSWTNAVRKAGFTPATEITEEELLIDLRRIANETVGDTLLKSDYKEYGEYSPSTALRRFGTWDEVVEKVGATSGDQKIPDEDLFADLRRVADEIDRRCLTKADYDERGKYSASTITARFESWGSAVKEAGLLPVSQWYGTTEQPSWTQLGRSPNECKIAKEDLLIDLRRVANKIEGDRIKARDYDQEGKYSATTVIRQFESWVNAVEKVGYKSHIKRIATEDLKHSLQNVGSEDEVPTSTEYAENGKYHYQTVIERFGSWSNAVQAAGYTSYSPPRTSWIPSEELIASIQTLSSEDEPPTSIEYDESGKFGTATVVRRFGTWANALQEAGYTSKQIDRLLPYTDDVEDEELLRELRRLADGEVGPTTHTIKTEGDYSTTPYFDRFGTIWQSVVCAGLKPYSRTPVTKTQYVDFIETVLDYGHPTRQLTGLLLAFTGLETTLTGKFSTEWVVNLNTSEETAIRVPKEHLQSDEDWILKVPSKWHNPETNQQETTHIEGLLNWAVNHEQELYSSTSGVESFLSMVNESIGIEGSRESHLTMALGTHLAERGAPPWFIQKQTGVGFRGMDAEVEDFYLWNYVHQGINHPDYNPPDVVLNPTGRIID L533R, H526T TPA_BK010831.1 DAC79865.1 tpg 195313 196506 + transport protein (probable substratephosphate/sulfate) Loose gnl|BL_ORD_ID|2087|hsp_num:0 Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime 31.82 3003807 fluoroquinolone antibiotic; cephalosporin; glycylcycline; penam; tetracycline antibiotic; rifamycin antibiotic; phenicol antibiotic; disinfecting agents and antiseptics antibiotic target alteration; antibiotic efflux resistance-nodulation-cell division (RND) antibiotic efflux pump tigecycline; ciprofloxacin; tetracycline; ceftazidime; rifampin; chloramphenicol; ampicillin; cefalotin; triclosan MASLLALVALVASMFMAFTVGANSNSAPIAPAVGANALSTLRGALLVGIVAGLGAISQGGSISETIGHGLVTGVTITPLAAAATLLTAATLITIGNSRGYPIPSAFTVTGAAVGAGVALGGGFAVGTYLNILGFWFAIPIVEGVLAYALARVLIGDRVPDHVTVPVLAGGVGYALAMIRLSVLPAPQGARATVAGVVARHLPAGVVPTTALGVAGAIAVVLAGAMYWQLRRDVTTGIHRLLVGLALAVLFTSGGSQVGLATGPLEPVFESALDLPAIYLLVLGGVGILVGGWVRSPRLIQAVAREYASLGPKRSIAAFIPAFLTAQAAIMFGYPISFNKVMISSIIGAGLVGGAADTGGVSVTKTGYTVAAWVGSMVGGAVLSFGLYRLLAAIPGLQ